@sjcrh/proteinpaint-client 2.198.0 → 2.200.0

package/dist/chunk-7JRDJNLR.js

@@ -0,0 +1,263 @@
+import {
+  CATEGORICAL,
+  COHORT,
+  CONDITION,
+  DATE,
+  DNA_METHYLATION,
+  FLOAT,
+  GENE_EXPRESSION,
+  GENE_VARIANT,
+  INTEGER,
+  ISOFORM_EXPRESSION,
+  JUNCTION,
+  METABOLITE_INTENSITY,
+  MULTIVALUE,
+  PROTEOME_ABUNDANCE,
+  PSEUDOBULK,
+  SAMPLELST,
+  SINGLECELL_CELLTYPE,
+  SINGLECELL_GENE_EXPRESSION,
+  SNP,
+  SNP_LIST,
+  SNP_LOCUS,
+  SSGSEA,
+  SURVIVAL,
+  TERM_COLLECTION,
+  TermTypeGroups,
+  dtTerms,
+  dtdnamethylation,
+  dtgeneexpression,
+  dtmetaboliteintensity,
+  dtproteomeabundance,
+  dtssgsea
+} from "./chunk-6PNPHACF.js";
+
+// ../shared/utils/dist/src/terms.js
+var ROOT_SAMPLE_TYPE = 1;
+var DEFAULT_SAMPLE_TYPE = 2;
+var NumericModes = {
+  continuous: "continuous",
+  discrete: "discrete"
+};
+var dtTermTypes = new Set(dtTerms.map((t) => t.type));
+var TermTypes2Dt = {
+  [GENE_EXPRESSION]: dtgeneexpression,
+  [SSGSEA]: dtssgsea,
+  [DNA_METHYLATION]: dtdnamethylation,
+  [METABOLITE_INTENSITY]: dtmetaboliteintensity,
+  [PROTEOME_ABUNDANCE]: dtproteomeabundance
+};
+var typeGroup = {
+  [CATEGORICAL]: TermTypeGroups.DICTIONARY_VARIABLES,
+  [CONDITION]: TermTypeGroups.DICTIONARY_VARIABLES,
+  [FLOAT]: TermTypeGroups.DICTIONARY_VARIABLES,
+  [INTEGER]: TermTypeGroups.DICTIONARY_VARIABLES,
+  [SAMPLELST]: TermTypeGroups.DICTIONARY_VARIABLES,
+  [SURVIVAL]: TermTypeGroups.DICTIONARY_VARIABLES,
+  [DATE]: TermTypeGroups.DICTIONARY_VARIABLES,
+  [MULTIVALUE]: TermTypeGroups.DICTIONARY_VARIABLES,
+  [GENE_VARIANT]: TermTypeGroups.MUTATION_CNV_FUSION,
+  [SNP]: TermTypeGroups.SNP,
+  [SNP_LIST]: TermTypeGroups.SNP_LIST,
+  [SNP_LOCUS]: TermTypeGroups.SNP_LOCUS,
+  [GENE_EXPRESSION]: TermTypeGroups.GENE_EXPRESSION,
+  [ISOFORM_EXPRESSION]: TermTypeGroups.ISOFORM_EXPRESSION,
+  [JUNCTION]: TermTypeGroups.SPLICE_JUNCTION,
+  [SSGSEA]: TermTypeGroups.SSGSEA,
+  [DNA_METHYLATION]: TermTypeGroups.DNA_METHYLATION,
+  [METABOLITE_INTENSITY]: TermTypeGroups.METABOLITE_INTENSITY,
+  [PROTEOME_ABUNDANCE]: TermTypeGroups.PROTEOME_ABUNDANCE,
+  [PSEUDOBULK]: TermTypeGroups.PSEUDOBULK,
+  [TERM_COLLECTION]: TermTypeGroups.TERM_COLLECTION,
+  [SINGLECELL_CELLTYPE]: TermTypeGroups.SINGLECELL_CELLTYPE,
+  [SINGLECELL_GENE_EXPRESSION]: TermTypeGroups.SINGLECELL_GENE_EXPRESSION,
+  [COHORT]: TermTypeGroups.COHORT
+};
+var nonDictTypes = /* @__PURE__ */ new Set([
+  SNP,
+  SNP_LIST,
+  SNP_LOCUS,
+  GENE_EXPRESSION,
+  ISOFORM_EXPRESSION,
+  JUNCTION,
+  SSGSEA,
+  DNA_METHYLATION,
+  GENE_VARIANT,
+  METABOLITE_INTENSITY,
+  PROTEOME_ABUNDANCE,
+  PSEUDOBULK,
+  SINGLECELL_CELLTYPE,
+  SINGLECELL_GENE_EXPRESSION,
+  COHORT
+]);
+for (const dtTermType of dtTermTypes) {
+  nonDictTypes.add(dtTermType);
+}
+var numericTypes = /* @__PURE__ */ new Set([
+  INTEGER,
+  FLOAT,
+  GENE_EXPRESSION,
+  ISOFORM_EXPRESSION,
+  JUNCTION,
+  SSGSEA,
+  DNA_METHYLATION,
+  METABOLITE_INTENSITY,
+  PROTEOME_ABUNDANCE,
+  SINGLECELL_GENE_EXPRESSION,
+  DATE,
+  PSEUDOBULK
+]);
+var dictionaryNumericTypes = /* @__PURE__ */ new Set([INTEGER, FLOAT, DATE]);
+var categoricalTypes = /* @__PURE__ */ new Set([CATEGORICAL, SNP]);
+var singleCellTerms = /* @__PURE__ */ new Set([
+  SINGLECELL_CELLTYPE,
+  SINGLECELL_GENE_EXPRESSION
+  /*PSEUDOBULK*/
+]);
+function isSingleCellTerm(term) {
+  if (!term) return false;
+  return singleCellTerms.has(term.type);
+}
+function isNumericTerm(term) {
+  if (!term) return false;
+  return numericTypes.has(term.type);
+}
+function isNumericTw(tw) {
+  if (!tw?.term) return false;
+  return isNumericTerm(tw.term) || tw.term.type === TERM_COLLECTION && tw.term.memberType === "numeric" && tw.type === "TermCollectionTWFraction";
+}
+function isCategoricalTerm(term) {
+  if (!term) return false;
+  return categoricalTypes.has(term.type);
+}
+function isDictionaryType(type) {
+  return !isNonDictionaryType(type);
+}
+function isNonDictionaryType(type) {
+  if (!type) throw new Error("Type is not defined");
+  return nonDictTypes.has(type);
+}
+function isNumTermCollection(term) {
+  if (!term || !term.type) throw new Error("Term or term type is not defined");
+  return term.type === TERM_COLLECTION;
+}
+function equals(t1, t2) {
+  if (!t1) throw new Error("First term is not defined ");
+  if (!t2) throw new Error("Second term is not defined ");
+  if (t1.type !== t2.type) return false;
+  if (isDictionaryType(t1.type) && isDictionaryType(t2.type) && t1.type != SAMPLELST) return t1.id === t2.id;
+  switch (t1.type) {
+    case GENE_EXPRESSION:
+      return t1.gene == t2.gene;
+    case ISOFORM_EXPRESSION:
+      return t1.isoform == t2.isoform;
+    case JUNCTION:
+      return t1.chr == t2.chr && t1.start == t2.start && t1.stop == t2.stop && t1.strand == t2.strand;
+    case SSGSEA:
+      return t1.id == t2.id;
+    case DNA_METHYLATION:
+      return t1.chr == t2.chr && t1.start == t2.start && t1.stop == t2.stop;
+    case METABOLITE_INTENSITY:
+    case PROTEOME_ABUNDANCE:
+      return t1.name == t2.name;
+    case GENE_VARIANT:
+      return t1.gene == t2.gene || t1.chr == t2.chr && t1.start == t2.start && t1.stop == t2.stop;
+    // TO DO: Add more cases
+    // case SNP_LIST:
+    // case SNP_LOCUS:
+    // case SAMPLELST:
+    default:
+      return false;
+  }
+}
+var typeMap = {
+  categorical: "Categorical",
+  condition: "Condition",
+  float: "Numerical",
+  integer: "Numerical",
+  date: "Date",
+  geneExpression: "Gene Expression",
+  isoformExpression: "Isoform Expression",
+  [JUNCTION]: "Splice junction",
+  ssGSEA: "Geneset Expression",
+  dnaMethylation: "DNA Methylation",
+  geneVariant: "Gene Variant",
+  metaboliteIntensity: "Metabolite Intensity",
+  proteomeAbundance: "Proteome Abundance",
+  proteomeDAP: "Proteome DAP",
+  multivalue: "Multi Value",
+  singleCellGeneExpression: "Single Cell, Gene Expression",
+  singleCellCellType: "Single Cell, Cell Type",
+  snplocus: "SNP Locus",
+  snp: "SNP",
+  snplst: "SNP List",
+  termCollection: "Term Collection"
+};
+function termItemType(t) {
+  switch (t.type) {
+    case JUNCTION:
+      return "Splice junction";
+    case GENE_EXPRESSION:
+    case SINGLECELL_GENE_EXPRESSION:
+      return "Gene";
+    case ISOFORM_EXPRESSION:
+      return "Isoform";
+    case SSGSEA:
+      return "Gene set";
+    case METABOLITE_INTENSITY:
+      return "Metabolite";
+    // keep adding here
+    default:
+      return "Variable";
+  }
+}
+function termType2label(type) {
+  const s = typeMap[type];
+  if (s) return s;
+  throw new Error("termType2label(): unknown value");
+}
+function getDateFromNumber(value) {
+  const year = Math.floor(value);
+  const january1st = new Date(year, 0, 1);
+  const totalDays = getDaysInYear(year);
+  const time = Math.round((value - year) * totalDays) * oneDayTime;
+  const date = new Date(january1st.getTime() + time);
+  return date;
+}
+var oneDayTime = 24 * 60 * 60 * 1e3;
+function getDateStrFromNumber(value) {
+  const date = getDateFromNumber(value);
+  return date.toLocaleDateString("en-US", {
+    year: "numeric",
+    month: "long"
+  });
+}
+function getDaysInYear(year) {
+  const isLeap = new Date(year, 1, 29).getMonth() === 1;
+  const days = isLeap ? 366 : 365;
+  return days;
+}
+
+export {
+  ROOT_SAMPLE_TYPE,
+  DEFAULT_SAMPLE_TYPE,
+  NumericModes,
+  dtTermTypes,
+  TermTypes2Dt,
+  typeGroup,
+  numericTypes,
+  dictionaryNumericTypes,
+  isSingleCellTerm,
+  isNumericTerm,
+  isNumericTw,
+  isCategoricalTerm,
+  isDictionaryType,
+  isNonDictionaryType,
+  isNumTermCollection,
+  equals,
+  termItemType,
+  termType2label,
+  getDateFromNumber,
+  getDateStrFromNumber
+};
+//# sourceMappingURL=chunk-7JRDJNLR.js.map

package/dist/chunk-7JRDJNLR.js.map

@@ -0,0 +1,7 @@
+{
+  "version": 3,
+  "sources": ["../../shared/utils/src/terms.ts"],
+  "sourcesContent": ["import type { Term } from '#types'\nimport {\n\tdtgeneexpression,\n\tdtssgsea,\n\tdtdnamethylation,\n\tdtmetaboliteintensity,\n\tdtproteomeabundance,\n\tTermTypeGroups,\n\tdtTerms\n} from './common.js'\nimport {\n\tGENE_VARIANT,\n\tGENE_EXPRESSION,\n\tISOFORM_EXPRESSION,\n\tSSGSEA,\n\tDNA_METHYLATION,\n\tCATEGORICAL,\n\tINTEGER,\n\tJUNCTION,\n\tFLOAT,\n\tSNP,\n\tSNP_LIST,\n\tSNP_LOCUS,\n\tCONDITION,\n\tSURVIVAL,\n\tSAMPLELST,\n\tMETABOLITE_INTENSITY,\n\tPROTEOME_ABUNDANCE,\n\tPSEUDOBULK,\n\tSINGLECELL_CELLTYPE,\n\tSINGLECELL_GENE_EXPRESSION,\n\tMULTIVALUE,\n\tDATE,\n\tTERM_COLLECTION,\n\tCOHORT\n} from '#types'\n\n// moved TermTypeGroups to `server/src/common.js`, so now has to re-export\nexport { TermTypeGroups } from './common.js'\n\n/*\nFor datasets with multiple types of samples the ROOT_SAMPLE_TYPE is used to represent the root sample type, for example, \nthe type patient, that has one or more samples associated to it. This should be the id used as sample_type, when generating the db to identify the root samples\nin sampleidmap or the terms annotating root samples in the terms table.\nThe samples associated to a patient have annotations that are specific to a timepoint, for example, the age of the patient,\nthe doses of the drugs the patient was taking at the time of the data collection, etc. These annotations are associated to a sample.\n*/\nexport const ROOT_SAMPLE_TYPE = 1\n\n//For datasets with one sample type the DEFAULT_SAMPLE_TYPE is used to represent the sample type\nexport const DEFAULT_SAMPLE_TYPE = 2\n\nexport const NumericModes = {\n\tcontinuous: 'continuous',\n\tdiscrete: 'discrete'\n}\n\n// the dt term types are also declared in TermTypes, see the assertion in terms.unit.spec.ts\nexport const dtTermTypes: Set<string> = new Set(dtTerms.map((t: any) => t.type))\n\nexport const TermTypes2Dt = {\n\t[GENE_EXPRESSION]: dtgeneexpression,\n\t[SSGSEA]: dtssgsea,\n\t[DNA_METHYLATION]: dtdnamethylation,\n\t[METABOLITE_INTENSITY]: dtmetaboliteintensity,\n\t[PROTEOME_ABUNDANCE]: dtproteomeabundance\n}\n\n// maps term type to group (as is shown as toggles in search ui)\nexport const typeGroup = {\n\t[CATEGORICAL]: TermTypeGroups.DICTIONARY_VARIABLES,\n\t[CONDITION]: TermTypeGroups.DICTIONARY_VARIABLES,\n\t[FLOAT]: TermTypeGroups.DICTIONARY_VARIABLES,\n\t[INTEGER]: TermTypeGroups.DICTIONARY_VARIABLES,\n\t[SAMPLELST]: TermTypeGroups.DICTIONARY_VARIABLES,\n\t[SURVIVAL]: TermTypeGroups.DICTIONARY_VARIABLES,\n\t[DATE]: TermTypeGroups.DICTIONARY_VARIABLES,\n\t[MULTIVALUE]: TermTypeGroups.DICTIONARY_VARIABLES,\n\t[GENE_VARIANT]: TermTypeGroups.MUTATION_CNV_FUSION,\n\t[SNP]: TermTypeGroups.SNP,\n\t[SNP_LIST]: TermTypeGroups.SNP_LIST,\n\t[SNP_LOCUS]: TermTypeGroups.SNP_LOCUS,\n\t[GENE_EXPRESSION]: TermTypeGroups.GENE_EXPRESSION,\n\t[ISOFORM_EXPRESSION]: TermTypeGroups.ISOFORM_EXPRESSION,\n\t[JUNCTION]: TermTypeGroups.SPLICE_JUNCTION,\n\t[SSGSEA]: TermTypeGroups.SSGSEA,\n\t[DNA_METHYLATION]: TermTypeGroups.DNA_METHYLATION,\n\t[METABOLITE_INTENSITY]: TermTypeGroups.METABOLITE_INTENSITY,\n\t[PROTEOME_ABUNDANCE]: TermTypeGroups.PROTEOME_ABUNDANCE,\n\t[PSEUDOBULK]: TermTypeGroups.PSEUDOBULK,\n\t[TERM_COLLECTION]: TermTypeGroups.TERM_COLLECTION,\n\t[SINGLECELL_CELLTYPE]: TermTypeGroups.SINGLECELL_CELLTYPE,\n\t[SINGLECELL_GENE_EXPRESSION]: TermTypeGroups.SINGLECELL_GENE_EXPRESSION,\n\t[COHORT]: TermTypeGroups.COHORT\n}\n\nconst nonDictTypes = new Set([\n\tSNP,\n\tSNP_LIST,\n\tSNP_LOCUS,\n\tGENE_EXPRESSION,\n\tISOFORM_EXPRESSION,\n\tJUNCTION,\n\tSSGSEA,\n\tDNA_METHYLATION,\n\tGENE_VARIANT,\n\tMETABOLITE_INTENSITY,\n\tPROTEOME_ABUNDANCE,\n\tPSEUDOBULK,\n\tSINGLECELL_CELLTYPE,\n\tSINGLECELL_GENE_EXPRESSION,\n\tCOHORT\n])\n\nfor (const dtTermType of dtTermTypes) {\n\tnonDictTypes.add(dtTermType)\n}\n\nexport const numericTypes = new Set([\n\tINTEGER,\n\tFLOAT,\n\tGENE_EXPRESSION,\n\tISOFORM_EXPRESSION,\n\tJUNCTION,\n\tSSGSEA,\n\tDNA_METHYLATION,\n\tMETABOLITE_INTENSITY,\n\tPROTEOME_ABUNDANCE,\n\tSINGLECELL_GENE_EXPRESSION,\n\tDATE,\n\tPSEUDOBULK\n])\n\n// dictionary numeric term types, exists in db tables, exclude non-dictionary term types\nexport const dictionaryNumericTypes = new Set([INTEGER, FLOAT, DATE])\n\nconst categoricalTypes = new Set([CATEGORICAL, SNP])\n\nconst singleCellTerms = new Set([SINGLECELL_CELLTYPE, SINGLECELL_GENE_EXPRESSION /*PSEUDOBULK*/])\n\nexport function isSingleCellTerm(term: any) {\n\tif (!term) return false\n\treturn singleCellTerms.has(term.type)\n}\nexport function isNumericTerm(term: Term) {\n\tif (!term) return false\n\treturn numericTypes.has(term.type)\n}\n\n/** True when a term wrapper resolves to one numeric value per sample.\n * A termCollection in values mode is intentionally excluded because it retains\n * one value per member term rather than resolving to a scalar. */\nexport function isNumericTw(tw: any) {\n\tif (!tw?.term) return false\n\treturn (\n\t\tisNumericTerm(tw.term) ||\n\t\t(tw.term.type === TERM_COLLECTION && tw.term.memberType === 'numeric' && tw.type === 'TermCollectionTWFraction')\n\t)\n}\nexport function isCategoricalTerm(term: Term) {\n\tif (!term) return false\n\treturn categoricalTypes.has(term.type)\n}\n\nexport function isDictionaryType(type: string) {\n\treturn !isNonDictionaryType(type)\n}\n\nexport function isNonDictionaryType(type: string) {\n\tif (!type) throw new Error('Type is not defined')\n\treturn nonDictTypes.has(type)\n}\n\nexport function isNumTermCollection(term: Term) {\n\tif (!term || !term.type) throw new Error('Term or term type is not defined')\n\t//Enable this check when memberType is added to term collection\n\t// return term.type === TERM_COLLECTION && term.memberType == 'numeric'\n\treturn term.type === TERM_COLLECTION\n}\n\nexport function equals(t1: any, t2: any) {\n\tif (!t1) throw new Error('First term is not defined ')\n\tif (!t2) throw new Error('Second term is not defined ')\n\tif (t1.type !== t2.type) return false //term types are different\n\tif (isDictionaryType(t1.type) && isDictionaryType(t2.type) && t1.type != SAMPLELST) return t1.id === t2.id\n\tswitch (t1.type) {\n\t\tcase GENE_EXPRESSION:\n\t\t\treturn t1.gene == t2.gene\n\t\tcase ISOFORM_EXPRESSION:\n\t\t\treturn t1.isoform == t2.isoform\n\t\tcase JUNCTION:\n\t\t\treturn t1.chr == t2.chr && t1.start == t2.start && t1.stop == t2.stop && t1.strand == t2.strand\n\t\tcase SSGSEA:\n\t\t\treturn t1.id == t2.id\n\t\tcase DNA_METHYLATION:\n\t\t\treturn t1.chr == t2.chr && t1.start == t2.start && t1.stop == t2.stop\n\t\tcase METABOLITE_INTENSITY:\n\t\tcase PROTEOME_ABUNDANCE:\n\t\t\treturn t1.name == t2.name\n\t\tcase GENE_VARIANT:\n\t\t\treturn t1.gene == t2.gene || (t1.chr == t2.chr && t1.start == t2.start && t1.stop == t2.stop)\n\n\t\t// TO DO: Add more cases\n\t\t// case SNP_LIST:\n\t\t// case SNP_LOCUS:\n\t\t// case SAMPLELST:\n\n\t\tdefault:\n\t\t\treturn false\n\t}\n}\n\nexport function getBin(lst: any[], value: number) {\n\tlet bin = lst.findIndex(\n\t\tb => (b.startunbounded && value < b.stop) || (b.startunbounded && b.stopinclusive && value == b.stop)\n\t)\n\tif (bin == -1)\n\t\tbin = lst.findIndex(\n\t\t\tb => (b.stopunbounded && value > b.start) || (b.stopunbounded && b.startinclusive && value == b.start)\n\t\t)\n\tif (bin == -1)\n\t\tbin = lst.findIndex(\n\t\t\tb =>\n\t\t\t\t(value > b.start && value < b.stop) ||\n\t\t\t\t(b.startinclusive && value == b.start) ||\n\t\t\t\t(b.stopinclusive && value == b.stop)\n\t\t)\n\treturn bin\n}\n//Terms may  have a sample type associated to them, in datasets with multiple types of samples.\n//For example the gender is associated to the patient while the age is associated to the type sample. This function is used\n//for example when calling getData or getFilter, to return either the parent or the child samples, depending on the use case.\nexport function getSampleType(term: any, ds: any) {\n\tif (!term) return null\n\t//non dict terms annotate only samples, eg: gene expression, metabolite intensity, gene variant.\n\t//Their sample type is the default sample type that may or may not have a parent type, depending on the dataset\n\tif (term.type && isNonDictionaryType(term.type)) return DEFAULT_SAMPLE_TYPE\n\t//dictionary terms may annotate different types of samples, eg: patient and sample or mouse and crop.\n\tif (term.id) return ds.cohort.termdb.term2SampleType.get(term.id)\n\tif (term.type == 'samplelst') {\n\t\tconst key = Object.keys(term.values)[0]\n\t\tconst sampleId = term.values[key].list[0]?.sampleId\n\t\tif (sampleId) return ds.sampleId2Type.get(Number(sampleId) || sampleId)\n\t\telse return DEFAULT_SAMPLE_TYPE\n\t}\n\t// samplelst or non dict terms\n\treturn DEFAULT_SAMPLE_TYPE //later own term needs to know what type annotates based on the samples\n}\n\nexport function getParentType(types: Set<string>, ds: any) {\n\tif (Object.keys(ds.cohort.termdb.sampleTypes).length == 0) return null //dataset only has one type of sample\n\tconst ids = Array.from(types)\n\tif (!ids || ids.length == 0) return null\n\tfor (const id of ids) {\n\t\tconst typeObj = ds.cohort.termdb.sampleTypes[id]\n\t\tif (!typeObj) continue\n\t\tif (typeObj.parent_id == null) return id //this is the root type\n\t\t//if my parent is in the list, then I am not the parent\n\t\tif (ids.includes(typeObj.parent_id)) continue\n\t\telse return typeObj.parent_id //my parent is not in the list, so I am the parent\n\t}\n\treturn null //no parent found\n}\n\n// whether the term annotates parent samples\nexport function isParentType(term: any, ds: any) {\n\tif (!ds.cohort.termdb.hasSampleAncestry) return false\n\tconst sampleType = getSampleType(term, ds)\n\tif (!sampleType) throw 'sample type is not defined'\n\tconst sampleTypeObj = ds.cohort.termdb.sampleTypes[sampleType]\n\tif (!sampleTypeObj) throw 'invalid sample type'\n\tif (Number.isInteger(sampleTypeObj.parent_id)) {\n\t\t// sample type has parent, so it is child sample type\n\t\treturn false\n\t} else {\n\t\t// sample type does not have parent, so it is parent sample type\n\t\treturn true\n\t}\n}\n\n//Returns human readable label for each term type; label is just for printing and not computing\nconst typeMap: { [key: string]: string } = {\n\tcategorical: 'Categorical',\n\tcondition: 'Condition',\n\tfloat: 'Numerical',\n\tinteger: 'Numerical',\n\tdate: 'Date',\n\tgeneExpression: 'Gene Expression',\n\tisoformExpression: 'Isoform Expression',\n\t[JUNCTION]: 'Splice junction',\n\tssGSEA: 'Geneset Expression',\n\tdnaMethylation: 'DNA Methylation',\n\tgeneVariant: 'Gene Variant',\n\tmetaboliteIntensity: 'Metabolite Intensity',\n\tproteomeAbundance: 'Proteome Abundance',\n\tproteomeDAP: 'Proteome DAP',\n\tmultivalue: 'Multi Value',\n\tsingleCellGeneExpression: 'Single Cell, Gene Expression',\n\tsingleCellCellType: 'Single Cell, Cell Type',\n\tsnplocus: 'SNP Locus',\n\tsnp: 'SNP',\n\tsnplst: 'SNP List',\n\ttermCollection: 'Term Collection'\n}\n\n// with a term obj, returns human readable item type name for a term.\n// using a term obj rather than just term type gives more control (e.g. gene vs coord for genevariant term)\nexport function termItemType(t: Term): string {\n\tswitch (t.type) {\n\t\tcase JUNCTION:\n\t\t\treturn 'Splice junction'\n\t\tcase GENE_EXPRESSION:\n\t\tcase SINGLECELL_GENE_EXPRESSION:\n\t\t\treturn 'Gene'\n\t\tcase ISOFORM_EXPRESSION:\n\t\t\treturn 'Isoform'\n\t\tcase SSGSEA:\n\t\t\treturn 'Gene set'\n\t\tcase METABOLITE_INTENSITY:\n\t\t\treturn 'Metabolite'\n\t\t// keep adding here\n\t\tdefault:\n\t\t\treturn 'Variable'\n\t}\n}\n\nexport function termType2label(type: string) {\n\tconst s = typeMap[type]\n\tif (s) return s\n\tthrow new Error('termType2label(): unknown value')\n}\n\nexport function getDateFromNumber(value: number) {\n\tconst year = Math.floor(value)\n\tconst january1st = new Date(year, 0, 1)\n\tconst totalDays = getDaysInYear(year)\n\tconst time = Math.round((value - year) * totalDays) * oneDayTime\n\tconst date = new Date(january1st.getTime() + time)\n\treturn date\n}\n/*\nValue is a decimal year.\nA decimal year is a way of expressing a date or time period as a year with a decimal part, where the decimal portion \nrepresents the fraction of the year that has elapsed. \nExample:\n2025.0 represents the beginning of the year 2025. \n2025.5 represents the middle of the year 2025. \n */\nconst oneDayTime = 24 * 60 * 60 * 1000\n\nexport function getDateStrFromNumber(value: number) {\n\tconst date = getDateFromNumber(value)\n\n\t//Omit day to  deidentify the patients\n\treturn date.toLocaleDateString('en-US', {\n\t\tyear: 'numeric',\n\t\tmonth: 'long'\n\t})\n}\n\n//The value returned is a decimal year\n//A decimal year is a way of expressing a date or time period as a year with a decimal part, where the decimal portion\n//represents the fraction of the year that has elapsed.\nexport function getNumberFromDateStr(str: string) {\n\tconst date = new Date(str)\n\treturn getNumberFromDate(date)\n}\n\nexport function getNumberFromDate(date: Date) {\n\tconst year = date.getFullYear()\n\tconst january1st: Date = new Date(year, 0, 1)\n\tconst diffDays = (date.getTime() - january1st.getTime()) / oneDayTime\n\tconst daysTotal = getDaysInYear(year)\n\tconst decimal = diffDays / daysTotal\n\treturn year + decimal\n}\n\nexport function getDaysInYear(year: number) {\n\tconst isLeap = new Date(year, 1, 29).getMonth() === 1\n\tconst days = isLeap ? 366 : 365\n\treturn days\n}\n"],
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+  "names": []
+}

package/dist/chunk-7PIHRWGG.js

@@ -0,0 +1,102 @@
+import {
+  addGeneSearchbox,
+  first_genetrack_tolist,
+  getDNAMethUnit,
+  sayerror
+} from "./chunk-TKW5TW4Z.js";
+import {
+  Menu
+} from "./chunk-HYOEWQ5P.js";
+import {
+  DNA_METHYLATION
+} from "./chunk-6PNPHACF.js";
+
+// termdb/handlers/dnaMethylation.ts
+var SearchHandler = class {
+  init(opts) {
+    this.opts = opts;
+    this.callback = opts.callback;
+    this.app = opts.app;
+    const holder = opts.holder.append("div").style("margin", "10px 0px");
+    this.dom = {};
+    this.dom.errDiv = holder.append("div").style("margin", "5px 0px").style("display", "none");
+    this.dom.geneSearchDiv = holder.append("div");
+    this.dom.blockDiv = holder.append("div").style("display", "none").style("margin", "15px 4px");
+    const geneSearch = addGeneSearchbox({
+      tip: new Menu({ padding: "0px" }),
+      genome: opts.genomeObj,
+      row: this.dom.geneSearchDiv,
+      callback: async () => {
+        try {
+          this.dom.errDiv.style("display", "none");
+          await this.handleGeneSearch(geneSearch);
+        } catch (e) {
+          this.dom.errDiv.style("display", "block");
+          sayerror(this.dom.errDiv, "Error: " + (e.message || e));
+          if (e.stack) console.log(e.stack);
+        }
+      }
+    });
+  }
+  async handleGeneSearch(geneSearch) {
+    if (geneSearch.geneSymbol) {
+      const { chr, start, stop } = geneSearch;
+      if (!chr || !Number.isInteger(start) || !Number.isInteger(stop))
+        throw new Error("unable to retrieve gene coordinate");
+      this.dom.blockDiv.selectAll("*").remove();
+      this.dom.blockDiv.style("display", "block");
+      this.dom.blockDiv.append("div").style("opacity", 0.6).text("Navigate genome browser to desired region");
+      const arg = {
+        holder: this.dom.blockDiv,
+        genome: this.opts.genomeObj,
+        // genome obj
+        chr,
+        start,
+        stop,
+        tklst: [],
+        nobox: true,
+        width: 500,
+        hidegenelegend: true,
+        debugmode: this.opts.debug
+      };
+      first_genetrack_tolist(this.opts.genomeObj, arg.tklst);
+      const _ = await import("./block-BGSSF6XP.js");
+      this.blockInstance = new _.Block(arg);
+      this.dom.submitBtn = this.dom.blockDiv.append("div").attr("data-testid", "sjpp-dnaMethylation-submitDiv").style("margin", "10px 0px").append("button").style("border", "none").style("border-radius", "20px").style("padding", "10px 15px").text("Submit Region").on("click", async () => {
+        const { chr: chr2, start: start2, stop: stop2 } = this.blockInstance.rglst[0];
+        const term = this.makeTerm({ chr: chr2, start: start2, stop: stop2 });
+        await this.callback(term);
+      });
+    } else if (geneSearch.chr && Number.isInteger(geneSearch.start) && Number.isInteger(geneSearch.stop)) {
+      const { chr } = geneSearch;
+      let { start, stop } = geneSearch;
+      if (geneSearch.actualposition?.len <= 1) {
+        start = geneSearch.actualposition.position;
+        stop = start + 1;
+      }
+      const term = this.makeTerm({ chr, start, stop });
+      await this.callback(term);
+    } else {
+      throw new Error("invalid gene search input");
+    }
+  }
+  makeTerm(opts) {
+    const { chr, start, stop } = opts;
+    if (!chr || !Number.isInteger(start) || !Number.isInteger(stop)) throw new Error("invalid coordinate");
+    const unit = getDNAMethUnit("region", this.app.vocabApi);
+    const term = {
+      chr,
+      start,
+      stop,
+      type: DNA_METHYLATION,
+      unit,
+      genomicFeatureType: "region"
+    };
+    return term;
+  }
+};
+
+export {
+  SearchHandler
+};
+//# sourceMappingURL=chunk-7PIHRWGG.js.map

package/dist/chunk-7PIHRWGG.js.map

@@ -0,0 +1,7 @@
+{
+  "version": 3,
+  "sources": ["../termdb/handlers/dnaMethylation.ts"],
+  "sourcesContent": ["import { Menu, addGeneSearchbox, sayerror } from '#dom'\nimport { DNA_METHYLATION } from '#types'\nimport { getDNAMethUnit } from '#tw/dnaMethylation'\nimport { first_genetrack_tolist } from '#common/1stGenetk'\n\n/** Coordinate note: both the genome browser and the HDF5 beta file use 0-based\n coordinates. Verified by cross-referencing 5 probes from the test H5 file\n (dnaMeth.h5) against UCSC hg38 using the search API:\n   https://api.genome.ucsc.edu/search?search=<probeId>&genome=hg38\n\n H5 positions were read with:\n   python3 -c \"import h5py; h5=h5py.File('proteinpaint/server/test/tp/files/hg38/TermdbTest/dnaMeth.h5','r'); \\\n     print(list(zip(h5['/meta/probe/probeID'].asstr()[:5], h5['/meta/start'][:5])))\"\n\n All matched the 0-based half-open (BED) position returned by UCSC:\n   cg22949073: H5=7669073, UCSC=chr17:7669073-7669074\n   cg16397722: H5=7673772, UCSC=chr17:7673772-7673773\n   cg04405586: H5=7675143, UCSC=chr17:7675143-7675144\n   cg15110538: H5=7675305, UCSC=chr17:7675305-7675306\n   cg10792831: H5=7675371, UCSC=chr17:7675371-7675372\nNo conversion is needed. Single-position inputs (e.g. chr17:7661778) are\nrecovered from actualposition to avoid the 400bp expansion that string2pos()\napplies for the genome browser. */\n\nexport class SearchHandler {\n\topts: any\n\tcallback: any\n\tapp: any\n\tdom: any\n\tblockInstance: any\n\tinit(opts) {\n\t\tthis.opts = opts\n\t\tthis.callback = opts.callback\n\t\tthis.app = opts.app\n\t\tconst holder = opts.holder.append('div').style('margin', '10px 0px')\n\t\tthis.dom = {}\n\t\tthis.dom.errDiv = holder.append('div').style('margin', '5px 0px').style('display', 'none')\n\t\tthis.dom.geneSearchDiv = holder.append('div')\n\t\tthis.dom.blockDiv = holder.append('div').style('display', 'none').style('margin', '15px 4px')\n\t\tconst geneSearch = addGeneSearchbox({\n\t\t\ttip: new Menu({ padding: '0px' }),\n\t\t\tgenome: opts.genomeObj,\n\t\t\trow: this.dom.geneSearchDiv,\n\t\t\tcallback: async () => {\n\t\t\t\ttry {\n\t\t\t\t\tthis.dom.errDiv.style('display', 'none')\n\t\t\t\t\tawait this.handleGeneSearch(geneSearch)\n\t\t\t\t} catch (e: any) {\n\t\t\t\t\tthis.dom.errDiv.style('display', 'block')\n\t\t\t\t\tsayerror(this.dom.errDiv, 'Error: ' + (e.message || e))\n\t\t\t\t\tif (e.stack) console.log(e.stack)\n\t\t\t\t}\n\t\t\t}\n\t\t})\n\t}\n\n\tasync handleGeneSearch(geneSearch) {\n\t\tif (geneSearch.geneSymbol) {\n\t\t\t// gene input\n\t\t\t// embed block of gene locus to allow navigation to region of interest\n\t\t\tconst { chr, start, stop } = geneSearch\n\t\t\tif (!chr || !Number.isInteger(start) || !Number.isInteger(stop))\n\t\t\t\tthrow new Error('unable to retrieve gene coordinate')\n\n\t\t\tthis.dom.blockDiv.selectAll('*').remove()\n\t\t\tthis.dom.blockDiv.style('display', 'block')\n\t\t\tthis.dom.blockDiv.append('div').style('opacity', 0.6).text('Navigate genome browser to desired region')\n\n\t\t\tconst arg: any = {\n\t\t\t\tholder: this.dom.blockDiv,\n\t\t\t\tgenome: this.opts.genomeObj, // genome obj\n\t\t\t\tchr,\n\t\t\t\tstart,\n\t\t\t\tstop,\n\t\t\t\ttklst: [],\n\t\t\t\tnobox: true,\n\t\t\t\twidth: 500,\n\t\t\t\thidegenelegend: true,\n\t\t\t\tdebugmode: this.opts.debug\n\t\t\t}\n\t\t\tfirst_genetrack_tolist(this.opts.genomeObj, arg.tklst)\n\t\t\tconst _ = await import('#src/block')\n\t\t\tthis.blockInstance = new _.Block(arg)\n\n\t\t\tthis.dom.submitBtn = this.dom.blockDiv\n\t\t\t\t.append('div')\n\t\t\t\t.attr('data-testid', 'sjpp-dnaMethylation-submitDiv')\n\t\t\t\t.style('margin', '10px 0px')\n\t\t\t\t.append('button')\n\t\t\t\t.style('border', 'none')\n\t\t\t\t.style('border-radius', '20px')\n\t\t\t\t.style('padding', '10px 15px')\n\t\t\t\t.text('Submit Region')\n\t\t\t\t.on('click', async () => {\n\t\t\t\t\tconst { chr, start, stop } = this.blockInstance.rglst[0]\n\t\t\t\t\tconst term = this.makeTerm({ chr, start, stop })\n\t\t\t\t\tawait this.callback(term)\n\t\t\t\t})\n\t\t} else if (geneSearch.chr && Number.isInteger(geneSearch.start) && Number.isInteger(geneSearch.stop)) {\n\t\t\t// coordinate input\n\t\t\t// string2pos() expands single positions to a 400bp window for the\n\t\t\t// genome browser, but we need the exact position for CpG queries.\n\t\t\t// Use actualposition when it indicates a single-position input.\n\t\t\tconst { chr } = geneSearch\n\t\t\tlet { start, stop } = geneSearch\n\t\t\tif (geneSearch.actualposition?.len <= 1) {\n\t\t\t\tstart = geneSearch.actualposition.position\n\t\t\t\tstop = start + 1\n\t\t\t}\n\t\t\tconst term = this.makeTerm({ chr, start, stop })\n\t\t\tawait this.callback(term)\n\t\t} else {\n\t\t\tthrow new Error('invalid gene search input')\n\t\t}\n\t}\n\n\tmakeTerm(opts) {\n\t\tconst { chr, start, stop } = opts\n\t\tif (!chr || !Number.isInteger(start) || !Number.isInteger(stop)) throw new Error('invalid coordinate')\n\t\tconst unit = getDNAMethUnit('region', this.app.vocabApi)\n\n\t\tconst term = {\n\t\t\tchr,\n\t\t\tstart,\n\t\t\tstop,\n\t\t\ttype: DNA_METHYLATION,\n\t\t\tunit,\n\t\t\tgenomicFeatureType: 'region'\n\t\t}\n\t\treturn term\n\t}\n}\n"],
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+}