@sjcrh/proteinpaint-client 2.193.0 → 2.195.0

package/dist/chunk-ZDEMAKRA.js

@@ -0,0 +1,386 @@
+import {
+  CNVkey2order
+} from "./chunk-E2KY2IZS.js";
+import {
+  TermTypes
+} from "./chunk-UAALI7MC.js";
+import {
+  colorScaleMap,
+  dtcnv,
+  dtfusionrna,
+  dtgeneexpression,
+  dtsnvindel,
+  dtsv
+} from "./chunk-7KRS7L4U.js";
+import {
+  convertUnits
+} from "./chunk-JNITUVXP.js";
+
+// plots/matrix/matrix.cells.js
+function setNumericCellProps(cell, tw, anno, value, s, t, self, width, height, dx, dy, i) {
+  const key = anno.key;
+  const values = tw.term.values || {};
+  cell.label = "label" in anno ? anno.label : values[key]?.label ? values[key].label : key;
+  cell.fill = self.config.settings.matrix.twSpecificSettings?.[tw.$id]?.[key]?.color || anno.color || values[anno.key]?.color || self.data.refs.byTermId?.[tw.$id]?.bins?.find((b) => anno.key == b.name)?.color;
+  cell.order = t.ref.bins ? t.ref.bins.findIndex((bin) => bin.name == key) : 0;
+  if (tw.q?.mode == "continuous") {
+    const twSpecificSettings = self.config.settings.matrix.twSpecificSettings;
+    if (!twSpecificSettings[tw.$id]) twSpecificSettings[tw.$id] = {};
+    const twSettings = twSpecificSettings[tw.$id];
+    if (!twSettings.contBarH) twSettings.contBarH = s.barh;
+    if (!("gap" in twSettings)) twSettings.contBarGap = 4;
+    const specialValue = tw.term.values?.[cell.key];
+    if (specialValue?.uncomputable) {
+      cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+      cell.y = height * i;
+      cell.height = twSettings.contBarH;
+      cell.fill = "transparent";
+      const group = tw.legend?.group || tw.$id;
+      return;
+    }
+    cell.fill = self.config.settings.matrix.twSpecificSettings?.[tw.$id]?.contBarColor || "#555";
+    if (s.transpose) {
+      cell.height = t.scale(cell.key);
+      cell.x = twSettings.contBarGap;
+    } else {
+      const vc = cell.term.valueConversion;
+      let renderV = vc ? cell.key * vc.scaleFactor : cell.key;
+      if (tw.q.convert2ZScore) {
+        renderV = (renderV - t.mean) / t.std;
+        cell.fill = renderV > 0 ? "#FF6666" : "#6666FF";
+        cell.zscoreLabel = ` (Z-score: ${renderV.toFixed(2)})`;
+      }
+      cell.label = "label" in anno ? anno.label : values[key]?.label ? values[key].label : tw.term.unit ? `${cell.key.toFixed(2)} ${tw.term.unit}` : cell.key.toFixed(2);
+      cell.height = renderV >= 0 ? t.scales.pos(renderV) : t.scales.neg(renderV);
+      cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+      cell.y = renderV >= 0 ? t.counts.posMaxHt + twSettings.contBarGap - cell.height : t.counts.posMaxHt + twSettings.contBarGap;
+      cell.convertedValueLabel = !vc ? "" : convertUnits(cell.key, vc.fromUnit, vc.toUnit, vc.scaleFactor);
+    }
+  } else {
+    cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+    cell.y = height * i;
+    const group = tw.legend?.group || tw.$id;
+    return { ref: t.ref, group, value: key, entry: { key, label: cell.label, fill: cell.fill } };
+  }
+}
+function setSurvivalCellProps(cell, tw, anno, value, s, t, self, width, height, dx, dy, i) {
+  const key = tw.q?.mode == "continuous" ? anno.value : anno.key;
+  cell.key = key;
+  cell.label = tw.q?.mode == "continuous" ? tw.term.unit ? `${key} ${tw.term.unit}` : key : tw.term.values?.[key].label ? tw.term.values?.[key].label : "Exit code: " + key;
+  cell.fill = self.config.settings.matrix.twSpecificSettings?.[tw.$id]?.[key]?.color || (key == 1 ? "#a1a3a6" : "#a3c88b");
+  cell.order = 0;
+  if (tw.q?.mode == "continuous") {
+    const twSpecificSettings = self.config.settings.matrix.twSpecificSettings;
+    if (!twSpecificSettings[tw.$id]) twSpecificSettings[tw.$id] = {};
+    const twSettings = twSpecificSettings[tw.$id];
+    if (!twSettings.contBarH) twSettings.contBarH = s.barh;
+    if (!("gap" in twSettings)) twSettings.contBarGap = 4;
+    cell.exitCodeKey = tw.term.values?.[anno.key].label || "Exit code: " + anno.key;
+    cell.fill = self.config.settings.matrix.twSpecificSettings?.[tw.$id]?.[anno.key]?.color || (anno.key == 1 ? "#a1a3a6" : "#a3c88b");
+    if (s.transpose) {
+      cell.height = t.scale(cell.key);
+      cell.x = twSettings.contBarGap;
+    } else {
+      const vc = cell.term.valueConversion;
+      let renderV = vc ? cell.key * vc.scaleFactor : cell.key;
+      if (tw.q.convert2ZScore) {
+        renderV = (renderV - t.mean) / t.std;
+        cell.zscoreLabel = ` (Z-score: ${renderV.toFixed(2)})`;
+      }
+      cell.label = tw.term.unit ? `${cell.key.toFixed(2)} ${tw.term.unit}` : cell.key.toFixed(2);
+      cell.height = renderV >= 0 ? t.scales.pos(renderV) : t.scales.neg(renderV);
+      cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+      cell.y = renderV >= 0 ? t.counts.posMaxHt + twSettings.contBarGap - cell.height : t.counts.posMaxHt + twSettings.contBarGap;
+      cell.convertedValueLabel = !vc ? "" : convertUnits(cell.key, vc.fromUnit, vc.toUnit, vc.scaleFactor);
+    }
+  } else {
+    const vc = cell.term.valueConversion;
+    cell.timeToEventKey = vc ? convertUnits(anno.value, vc.fromUnit, vc.toUnit, vc.scaleFactor) : anno.value.toFixed(2);
+    cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+    cell.y = height * i;
+    const group = tw.legend?.group || tw.$id;
+    return { ref: t.ref, group, value: key, entry: { key, label: cell.label, fill: cell.fill } };
+  }
+}
+function setCategoricalCellProps(cell, tw, anno, value, s, t, self, width, height, dx, dy, i) {
+  const values = tw.term.values || {};
+  const key = anno.key;
+  cell.label = "label" in anno ? anno.label : values[key]?.label ? values[key].label : key;
+  cell.fill = self.config.settings.matrix.twSpecificSettings?.[tw.$id]?.[key]?.color || anno.color || values[anno.key]?.color;
+  cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+  cell.y = height * i;
+  const group = tw.legend?.group || tw.$id;
+  return { ref: t.ref, group, value: anno.key, entry: { key, label: cell.label, fill: cell.fill } };
+}
+function setGeneVariantCellProps(cell, tw, anno, value, s, t, self, width, height, dx, dy, i) {
+  if (tw.q?.type == "predefined-groupset" || tw.q?.type == "custom-groupset") {
+    cell.label = value;
+    const groupset = tw.q.type == "custom-groupset" ? tw.q.customset : tw.term.groupsetting.lst[tw.q.predefined_groupset_idx];
+    if (!groupset) throw "groupset not found";
+    const group = groupset.groups.find((group2) => group2.name == value);
+    if (!group) throw "group not found";
+    cell.fill = group.color;
+    cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+    cell.y = height * i;
+    return {
+      ref: t.ref,
+      group: tw.legend?.group || tw.$id,
+      value,
+      entry: { key: anno.key, label: cell.label, fill: cell.fill }
+    };
+  } else {
+    const values = anno.renderedValues || anno.filteredValues || anno.values || [anno.value];
+    const colorFromq = tw.q?.values && tw.q?.values[value.class]?.color;
+    cell.label = value.label || self.mclass[value.class].label;
+    cell.fill = self.getValueColor?.(value.value) || colorFromq || value.color || self.mclass[value.class]?.color;
+    cell.class = value.class;
+    cell.value = value;
+    const colw = self.dimensions.colw;
+    if (s.cellEncoding == "") {
+      cell.height = s.rowh / values.length;
+      cell.width = colw;
+      cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+      cell.y = height * i;
+    } else if (value.dt == dtsnvindel || value.dt == dtfusionrna || value.dt == dtsv) {
+      if (s.cellEncoding == "single") {
+        cell.height = s.rowh;
+        cell.width = colw;
+        cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+        cell.y = 0;
+      } else {
+        const divisor = 3;
+        cell.height = s.rowh / divisor;
+        cell.width = colw;
+        cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+        cell.y = height * 0.33333;
+        if (s.oncoPrintSNVindelCellBorder) {
+          cell.border = true;
+        }
+      }
+    } else if (value.dt == dtcnv || value.dt == dtgeneexpression) {
+      cell.height = s.rowh;
+      cell.width = colw;
+      cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+      cell.y = 0;
+    } else {
+      throw `cannot set cell props for dt='${value.dt}'`;
+    }
+    if (value.class == "Blank" || value.class == "WT") {
+      cell.label = `${self.dt2label[value.dt]} ${cell.label}`;
+    }
+    const byDt = self.state.termdbConfig.assayAvailability?.byDt;
+    const order = CNVkey2order(value.class);
+    if (value.dt == dtcnv) {
+      if (t.scales && value.class.startsWith("CNV_")) {
+        const {
+          /*maxLoss,*/
+          maxGain,
+          minLoss,
+          /*minGain,*/
+          absMax
+        } = t.scales;
+        value.scaledValue = value.value < 0 ? value.value / -absMax : value.value / absMax;
+        cell.fill = value.value < 0 ? t.scales.loss(value.scaledValue) : t.scales.gain(value.scaledValue);
+        return {
+          ref: t.ref,
+          group: "CNV",
+          value: value.class,
+          order: -1,
+          entry: {
+            key: value.class,
+            label: cell.label,
+            scale: value.class == "CNV_loss" ? t.scales.loss : t.scales.gain,
+            domain: t.domain ? t.domain : value.class == "CNV_loss" ? [0, -minLoss] : [0, maxGain],
+            colors: t.range,
+            scales: value.dt == 4 && t.scales,
+            minLabel: 0,
+            maxLabel: value.class == "CNV_loss" ? minLoss : maxGain,
+            order,
+            dt: value.dt,
+            origin: value.origin
+          }
+        };
+      } else {
+        const group = "CNV";
+        return {
+          ref: t.ref,
+          group,
+          value: value.class,
+          order: -1,
+          entry: { key: value.class, label: cell.label, fill: cell.fill, order, dt: value.dt, origin: value.origin }
+        };
+      }
+    } else if (value.dt == dtfusionrna && byDt?.[dtfusionrna]) {
+      const group = "Fusion RNA";
+      return {
+        ref: t.ref,
+        group,
+        value: value.class,
+        order: -1,
+        entry: { key: value.class, label: cell.label, fill: cell.fill, order, dt: value.dt, origin: value.origin }
+      };
+    } else if (value.dt == dtsv && byDt?.[dtsv]) {
+      const group = "Structural Variation";
+      return {
+        ref: t.ref,
+        group,
+        value: value.class,
+        order: -1,
+        entry: { key: value.class, label: cell.label, fill: cell.fill, order, dt: value.dt, origin: value.origin }
+      };
+    } else if (value.dt == dtgeneexpression) {
+      return {
+        ref: t.ref,
+        group: self.config.settings.hierCluster?.termGroupName || "Gene Expression",
+        value: value.class,
+        order: -1,
+        entry: {
+          key: value.class,
+          label: "",
+          scale: self.geneExpValues.scale,
+          domain: [0, 0.5, 1],
+          minLabel: self.geneExpValues.min,
+          maxLabel: self.geneExpValues.max,
+          order,
+          dt: value.dt,
+          origin: value.origin
+        }
+      };
+    } else {
+      const controlLabels = self.settings.matrix.controlLabels;
+      const group = tw.legend?.group || (value.origin ? `${value.origin[0].toUpperCase() + value.origin.slice(1)} ${controlLabels.Mutations}` : controlLabels.Mutations);
+      return {
+        ref: t.ref,
+        group,
+        value: value.class,
+        order: -2,
+        entry: { key: value.class, label: cell.label, fill: cell.fill, order, dt: value.dt, origin: value.origin }
+      };
+    }
+  }
+}
+function setHierClusterCellProps(cell, tw, anno, value, s, t, self, width, height, dx, dy, i) {
+  const values = anno.renderedValues || anno.filteredValues || anno.values || [anno.value];
+  cell.label = value.value;
+  cell.fill = self.getValueColor?.(value.value);
+  cell.value = value;
+  const colw = self.dimensions.colw;
+  cell.height = s.clusterRowh;
+  cell.width = colw;
+  cell.x = cell.totalIndex * dx + cell.grpIndex * s.colgspace;
+  cell.y = height * i;
+  const hierCluster = self.config.settings.hierCluster;
+  let groupName;
+  if (hierCluster?.termGroupName) {
+    groupName = hierCluster.termGroupName;
+  } else if (tw.term.type == "geneExpression") {
+    groupName = "Gene Expression";
+    const unit = self.app.vocabApi.termdbConfig.queries?.geneExpression?.unit;
+    if (hierCluster?.zScoreTransformation) groupName += " (Z-score)";
+    else if (unit) groupName += ` (${unit})`;
+  } else if (tw.term.type == "metaboliteIntensity") {
+    groupName = "Intensity";
+  } else if (tw.term.type == "proteomeAbundance") {
+    groupName = "Protein Abundance";
+  } else {
+    groupName = "Heatmap color scale";
+  }
+  return {
+    ref: t.ref,
+    group: groupName,
+    order: -1,
+    entry: {
+      label: "",
+      scale: self.hierClusterValues.scale,
+      domain: colorScaleMap[self.settings.hierCluster.colorScale].domain,
+      minLabel: self.hierClusterValues.min,
+      maxLabel: self.hierClusterValues.max,
+      order: 0,
+      dt: value.dt
+    }
+  };
+}
+function getEmptyCell(cellTemplate, s, d) {
+  const cell = Object.assign({}, cellTemplate);
+  cell.fill = s.cellbg;
+  cell.height = s.rowh;
+  cell.width = d.colw;
+  cell.x = cell.totalIndex * d.dx + cell.grpIndex * s.colgspace;
+  cell.y = 0;
+  return cell;
+}
+var setCellProps = {
+  // some of these have been replaced by addOns{setCellProps} in matrix.xtw.ts,
+  // but leaving here for now since non-classed tw's may still use these
+  categorical: setCategoricalCellProps,
+  condition: setCategoricalCellProps,
+  integer: setNumericCellProps,
+  float: setNumericCellProps,
+  survival: setSurvivalCellProps,
+  geneVariant: setGeneVariantCellProps,
+  hierCluster: setHierClusterCellProps,
+  [TermTypes.GENE_EXPRESSION]: setNumericCellProps,
+  [TermTypes.METABOLITE_INTENSITY]: setNumericCellProps,
+  [TermTypes.PROTEOME_ABUNDANCE]: setNumericCellProps
+  //termCollection: setTermCollectionCellProps
+};
+var maySetEmptyCell = {
+  geneVariant: setVariantEmptyCell,
+  integer: setNumericEmptyCell,
+  float: setNumericEmptyCell,
+  categorical: setDefaultEmptyCell,
+  condition: setDefaultEmptyCell,
+  survival: setNumericEmptyCell,
+  [TermTypes.GENE_EXPRESSION]: setNumericEmptyCell,
+  [TermTypes.METABOLITE_INTENSITY]: setNumericEmptyCell,
+  [TermTypes.PROTEOME_ABUNDANCE]: setNumericEmptyCell
+};
+function setVariantEmptyCell(siblingCells, cellTemplate, s, d) {
+  if (siblingCells.find((c) => c.value.dt == dtcnv)) return;
+  const cell = Object.assign({}, cellTemplate);
+  cell.fill = s.cellbg;
+  cell.height = s.rowh;
+  cell.width = d.colw;
+  cell.x = cell.totalIndex * d.dx + cell.grpIndex * s.colgspace;
+  cell.y = 0;
+  return cell;
+}
+function setNumericEmptyCell(siblingCells, cellTemplate, s, d, self) {
+  const q = cellTemplate.tw.q;
+  if (q.mode != "continuous") {
+    if (siblingCells.length) return;
+    setDefaultEmptyCell(siblingCells, cellTemplate, s, d);
+  } else {
+    if (q?.mode != "continuous") return;
+    const twSpecificSettings = self.config.settings.matrix.twSpecificSettings;
+    const twSettings = twSpecificSettings[cellTemplate.$id];
+    const h = twSettings ? twSettings.contBarH + 2 * twSettings.contBarGap : s.rowh;
+    if (cellTemplate.height >= h) return;
+    const cell = Object.assign({}, cellTemplate);
+    cell.fill = s.cellbg;
+    cell.height = h || s.rowh;
+    cell.width = d.colw;
+    cell.x = cell.totalIndex * d.dx + cell.grpIndex * s.colgspace;
+    cell.y = 0;
+    return cell;
+  }
+}
+function setDefaultEmptyCell(siblingCells, cellTemplate, s, d) {
+  if (siblingCells.length) return;
+  const cell = Object.assign({}, cellTemplate);
+  cell.fill = s.cellbg;
+  cell.height = s.rowh;
+  cell.width = d.colw;
+  cell.x = cell.totalIndex * d.dx + cell.grpIndex * s.colgspace;
+  cell.y = 0;
+  return cell;
+}
+
+export {
+  setGeneVariantCellProps,
+  setHierClusterCellProps,
+  getEmptyCell,
+  setCellProps,
+  maySetEmptyCell
+};
+//# sourceMappingURL=chunk-ZDEMAKRA.js.map

package/dist/chunk-ZTJLENGZ.js

@@ -0,0 +1,292 @@
+import {
+  getSortOptions
+} from "./chunk-VZBMCJBR.js";
+import {
+  defaultUiLabels,
+  fillTermWrapper
+} from "./chunk-LYULXXGR.js";
+import {
+  copyMerge
+} from "./chunk-M3J4MINX.js";
+import {
+  isDictionaryType
+} from "./chunk-UAALI7MC.js";
+import {
+  CNVClasses,
+  dtcnv,
+  mclass,
+  mutationClasses,
+  proteinChangingMutations,
+  synonymousMutations,
+  truncatingMutations
+} from "./chunk-7KRS7L4U.js";
+
+// plots/matrix/matrix.config.js
+async function getPlotConfig(opts = {}, app) {
+  const controlLabels = structuredClone(defaultUiLabels);
+  const devicePixelRatio = opts.devicePixelRatio || window.devicePixelRatio;
+  const config = {
+    // data configuration
+    termgroups: [],
+    samplegroups: [],
+    divideBy: null,
+    legendValueFilter: {
+      isAtomic: true,
+      type: "tvslst",
+      in: true,
+      join: "and",
+      lst: []
+    },
+    legendGrpFilter: {
+      isAtomic: true,
+      type: "tvslst",
+      in: true,
+      join: "and",
+      lst: []
+    },
+    filter: {
+      isAtomic: true,
+      type: "tvslst",
+      in: true,
+      join: "and",
+      lst: []
+    },
+    // cnvCutoffs: {},
+    // rendering options
+    settings: {
+      matrix: {
+        svgCanvasSwitch: 1e3,
+        // the number of samples to trigger switching between svg and canvas
+        useMinPixelWidth: true,
+        // canvas may be hazy if false, but more accurately reflects column density
+        cellEncoding: "",
+        // can be "oncoprint" | "stacked" | "single"
+        margin: {
+          top: 10,
+          right: 5,
+          bottom: 20,
+          left: 50
+        },
+        // set any dataset-defined sample limits and sort priority, otherwise undefined
+        // put in settings, so that later may be overridden by a user
+        maxGenes: opts.settings?.maxGenes || 50,
+        maxSample: opts.settings?.maxSample || 1e3,
+        sampleNameFilter: "",
+        sortSamplesBy: "a",
+        sortPriority: void 0,
+        // will be filled-in
+        // sortByMutation: 'consequence', computed
+        // sortByCNV: true, computed
+        //sortOptions: getSortOptions(app.vocabApi.termdbConfig, controlLabels),
+        sortSampleGrpsBy: "name",
+        // 'hits' | 'name' | 'sampleCount'
+        sortSamplesTieBreakers: [{
+          $id: "sample",
+          sortSamples: {}
+          /*split: {char: '', index: 0}*/
+        }],
+        sortTermsBy: "sampleCount",
+        // or 'as listed'
+        // do not show number of samples at hiercluster gene row labels
+        samplecount4gene: opts.chartType == "hierCluster" ? "" : "abs",
+        //true, // 'abs' (default, previously true), 'pct', ''  (previously false)
+        geneVariantCountSamplesSkipMclass: [],
+        cellbg: "#ececec",
+        showGrid: "",
+        // false | 'pattern' | 'rect'
+        // whether to show these controls buttons
+        addMutationCNVButtons: false,
+        truncatingMutations,
+        proteinChangingMutations,
+        synonymousMutations,
+        mutationClasses,
+        CNVClasses,
+        gridStroke: "#fff",
+        outlineStroke: "#ccc",
+        beamStroke: "#f00",
+        colw: 0,
+        colwMin: 0.1 / devicePixelRatio,
+        colwMax: 16,
+        colspace: 1,
+        colgspace: 8,
+        colglabelpos: true,
+        collabelpos: "bottom",
+        collabelvisible: true,
+        collabelgap: 5,
+        collabelpad: 1,
+        collabelmaxchars: 32,
+        rowh: 18,
+        //use 0 to auto-compute row height, previous default=18,
+        rowhMin: 1,
+        rowhMax: 20,
+        rowspace: 1,
+        rowgspace: 8,
+        rowlabelpos: "left",
+        // | 'right'
+        rowlabelgap: 5,
+        rowlabelvisible: true,
+        rowlabelpad: 1,
+        rowlabelmaxchars: 32,
+        legendGrpLabelMaxChars: 26,
+        grpLabelFontSize: 12,
+        minLabelFontSize: 6,
+        maxLabelFontSize: 14,
+        transpose: false,
+        // 'auto' shows column labels only when columns are wide enough (colw >= minLabelFontSize);
+        sampleLabelsToggle: "auto",
+        // 'auto' | 'hide'
+        sampleLabelOffset: 120,
+        sampleGrpLabelOffset: 120,
+        sampleGrpLabelMaxChars: 32,
+        termLabelOffset: 80,
+        termGrpLabelOffset: 80,
+        termGrpLabelMaxChars: 32,
+        duration: 0,
+        zoomLevel: 1,
+        zoomCenterPct: 0,
+        zoomIndex: 0,
+        zoomGrpIndex: 0,
+        zoomMin: 0.5,
+        zoomIncrement: 0.1,
+        zoomStep: 1,
+        // renderedWMax should not be exposed as a user-input
+        // 60000 pixels is based on laptop and external monitor tests,
+        // when a canvas dataURL image in a zoomed-in matrix svg stops rendering
+        imgWMax: 6e4 / devicePixelRatio,
+        scrollHeight: 12,
+        controlLabels,
+        cnvUnit: "log2ratio",
+        ignoreCnvValues: false,
+        //will ignore numeric CNV values if true
+        barh: 32,
+        // default bar height for continuous terms,
+        // possible string entries:
+        // - "genesetEdit", for gene-centric embedders only like GDC OncoMatrix
+        // - may add other optional hints later
+        showHints: [],
+        genesetEditUiVersion: "",
+        // '' | 'withTabs'
+        // settings for a specific tw
+        twSpecificSettings: {},
+        oncoPrintSNVindelCellBorder: false,
+        // whether to show white cell border for SNVindel in oncoPrint mode
+        cnvValues: {
+          //Properties match the args for the ColorScales
+          //numericInput arg
+          cutoffMode: "percentile",
+          defaultPercentile: 99,
+          min: null,
+          max: null,
+          percentile: 99
+        }
+      }
+    }
+  };
+  const s = config.settings;
+  const fontsize = Math.max(s.matrix.rowh + s.matrix.rowspace - 3 * s.matrix.rowlabelpad, 12);
+  s.legend = {
+    ontop: false,
+    lineh: 25,
+    padx: 5,
+    padleft: 0,
+    //150,
+    padright: 20,
+    padbtm: 30,
+    fontsize,
+    iconh: fontsize - 2,
+    iconw: fontsize - 2,
+    hangleft: 1,
+    linesep: false
+  };
+  const overrides = app.vocabApi.termdbConfig.matrix || {};
+  copyMerge(config.settings.matrix, overrides.settings);
+  if (overrides.legendGrpFilter) config.legendGrpFilter = overrides.legendGrpFilter;
+  if (overrides.legendValueFilter) config.legendValueFilter = overrides.legendValueFilter;
+  if (overrides.filter) config.filter = overrides.filter;
+  if (opts.name) {
+    const data = await app.vocabApi.getMatrixByName(opts.name);
+    if (!data) throw "error from getMatrixByName()";
+    if (data.error) throw data.error;
+    copyMerge(config, data);
+  }
+  const os = opts?.settings?.matrix;
+  if (os) {
+    if ((os.sortSamplesBy == "custom" || os.sortSamplesBy == "asListed") && os.sortOptions?.custom.label == "against alteration type") {
+      os.sortSamplesBy = "a";
+    }
+    if (os.sortOptions) {
+      delete os.sortOptions.custom;
+      delete os.sortOptions.asListed;
+    }
+  }
+  copyMerge(config, opts);
+  const m = config.settings.matrix;
+  m.sortOptions = getSortOptions(app.vocabApi.termdbConfig, controlLabels, m);
+  m.duration = 0;
+  m.colw = 0;
+  if (m.sortSamplesBy != "asListed" && !m.sortOptions?.[m.sortSamplesBy]) m.sortSamplesBy = "a";
+  else if (["selectedTerms", "class", "dt", "hits"].includes(m.sortSamplesBy)) m.sortSamplesBy = "a";
+  if (m.samplecount4gene === true || m.samplecount4gene === 1) m.samplecount4gene = "abs";
+  if (window.location.hostname == "localhost") {
+    if (window.location.hash == "#canvas") m.svgCanvasSwitch = 0;
+  }
+  for (const grp of config.termgroups) {
+    const promises = [];
+    for (const tw of grp.lst) {
+      if (!tw.term?.type || isDictionaryType(tw.term.type)) {
+        if (!tw.id && tw.term.type != "samplelst" && tw.term.type != "termCollection") {
+          if (!tw.term.id) throw `missing tw.id and tw.term.id`;
+          tw.id = tw.term.id;
+        }
+        if (tw.term?.type != "samplelst" && tw.term?.type != "termCollection") delete tw.term;
+      }
+      promises.push(fillTermWrapper(tw, app.vocabApi));
+    }
+    grp.lst = await Promise.all(promises);
+  }
+  if (config.divideBy) config.divideBy = await fillTermWrapper(config.divideBy, app.vocabApi);
+  return config;
+}
+function setComputedConfig(config) {
+  const s = config.settings.matrix;
+  const allClasses = [...s.mutationClasses, ...s.CNVClasses];
+  s.filterByClass = { isAtomic: true };
+  for (const f of config.legendGrpFilter.lst) {
+    if (!f.dt) continue;
+    allClasses.filter((m) => f.dt.includes(mclass[m].dt)).forEach((key2) => {
+      s.filterByClass[key2] = "value";
+    });
+  }
+  for (const f of config.legendValueFilter.lst) {
+    if (!f.legendGrpName || f.tvs?.term?.type !== "geneVariant") continue;
+    if (f.tvs.values?.[0].mclasslst)
+      f.tvs.values[0].mclasslst.forEach((key2) => {
+        s.filterByClass[key2] = f.legendFilterType?.endsWith("_hard") ? "case" : "value";
+      });
+    else if (f.tvs.values)
+      f.tvs.values.forEach((v) => {
+        s.filterByClass[key] = "value";
+      });
+    else throw `unhandled tvs from legendValueFilter`;
+  }
+  s.hiddenVariants = Object.keys(s.filterByClass).filter((c) => c !== "isAtomic");
+  const hiddenCNVs = new Set(s.hiddenVariants.filter((key2) => mclass[key2]?.dt === dtcnv));
+  s.hiddenCNVs = [...hiddenCNVs];
+  s.showMatrixCNV = !hiddenCNVs.size ? "all" : hiddenCNVs.size == s.CNVClasses.length ? "none" : "bySelection";
+  s.allMatrixCNVHidden = hiddenCNVs.size == s.CNVClasses.length;
+  const hiddenMutations = new Set(s.hiddenVariants.filter((key2) => s.mutationClasses.find((k) => k === key2)));
+  s.hiddenMutations = [...hiddenMutations];
+  const PCset = new Set(s.proteinChangingMutations);
+  const TMset = new Set(s.truncatingMutations);
+  s.showMatrixMutation = !hiddenMutations.size ? "all" : hiddenMutations.size == s.mutationClasses.length ? "none" : hiddenMutations.size === s.mutationClasses.length - PCset.size && [...hiddenMutations].every((m) => !PCset.has(m)) ? "onlyPC" : hiddenMutations.size === s.mutationClasses.length - TMset.size && [...hiddenMutations].every((m) => !TMset.has(m)) ? "onlyTruncating" : "bySelection";
+  s.allMatrixMutationHidden = hiddenMutations.size == s.mutationClasses.length;
+  const tiebreakers = s.sortOptions.a?.sortPriority.find((sp) => sp.types.length == 1 && sp.types[0] == "geneVariant")?.tiebreakers || [];
+  s.sortByMutation = tiebreakers.find((tb) => tb.filter?.values[0]?.dt === 1)?.isOrdered ? "consequence" : "presence";
+  s.sortByCNV = tiebreakers.find((tb) => tb.filter?.values[0]?.dt === 4)?.disabled !== true;
+}
+
+export {
+  getPlotConfig,
+  setComputedConfig
+};
+//# sourceMappingURL=chunk-ZTJLENGZ.js.map