@sjcrh/proteinpaint-client 2.183.0 → 2.183.1

package/dist/chunk-K6ZAAZKO.js.map

@@ -0,0 +1,7 @@
+{
+  "version": 3,
+  "sources": ["../plots/survival/survival.ts"],
+  "sourcesContent": ["import { getCompInit, copyMerge, type RxComponent, type ComponentApi } from '#rx'\nimport { PlotBase, defaultUiLabels } from '#plots/PlotBase.ts'\nimport { controlsInit, term0_term2_defaultQ } from '#plots/controls.js'\nimport { select } from 'd3-selection'\nimport { scaleLinear, scaleOrdinal } from 'd3-scale'\nimport { schemeCategory10 } from 'd3-scale-chromatic'\nimport { schemeCategory20 } from '#common/legacy-d3-polyfill'\nimport { axisLeft, axisBottom } from 'd3-axis'\nimport { line, area, curveStepAfter } from 'd3-shape'\nimport { rgb } from 'd3-color'\nimport htmlLegend from '#dom/html.legend'\nimport Partjson from 'partjson'\nimport { rgb2hex } from '#src/client'\nimport { fillTermWrapper } from '#termsetting'\nimport { Menu } from '#dom/menu'\nimport { getSeriesTip } from '#dom/svgSeriesTips'\nimport { renderAtRiskG } from '#dom/renderAtRisk'\nimport { renderPvalues } from '#dom/renderPvalueTable'\nimport { downloadChart } from '#common/svg.download'\nimport { getCombinedTermFilter } from '#filter'\nimport { DownloadMenu } from '#dom/downloadMenu'\nimport { isNumericTerm } from '#shared/terms.js'\n\nexport const t0_t2_defaultQ = structuredClone(term0_term2_defaultQ)\nObject.assign(t0_t2_defaultQ, {\n\tnumeric: {\n\t\tmode: 'discrete',\n\t\ttype: 'custom-bin',\n\t\tpreferredBins: 'median'\n\t},\n\tgeneExpression: {\n\t\tmode: 'discrete',\n\t\ttype: 'custom-bin',\n\t\tpreferredBins: 'median'\n\t}\n})\n\nclass TdbSurvival extends PlotBase implements RxComponent {\n\tstatic type = 'survival'\n\n\t// expected RxComponent props, some are already declared/set in PlotBase\n\ttype: string\n\tparentId?: string\n\tdom!: {\n\t\t[index: string]: any\n\t}\n\tcomponents: { [name: string]: ComponentApi } = {}\n\n\t// expected class-specific props\n\tconfigTermKeys = ['term', 'term0', 'term2']\n\tsettings: any\n\tlineFxn: any\n\tpj: any\n\tactiveMenu = false\n\tlegendRenderer: any\n\thiddenRenderer: any\n\tlegendClick = (_, __, ___) => {}\n\tdownload: () => void = () => {}\n\tgetChartImages = () => this.getChartImages()\n\tloadingWait = 0\n\n\tcolorScale: any\n\n\trefs: any\n\tsymbol: any\n\tserverData?: any\n\tcurrData?: any\n\tlegendData?: any\n\tlegendOrder: any[] = []\n\thiddenData?: any\n\ttests?: { [name: string]: any }\n\tterm2toColor: { [name: string]: { orig: string; rgb: any; adjusted: string; hex: string } } = {}\n\n\tuniqueSeriesIds: Set<any> = new Set()\n\n\t// TODO: migrate to this.view method\n\trender = () => {}\n\tgetSymbol = (_: number) => {\n\t\treturn ''\n\t}\n\n\tconstructor(opts, api) {\n\t\tsuper(opts, api)\n\t\tthis.type = TdbSurvival.type\n\t\tthis.settings = Object.assign({}, opts.settings)\n\t\tthis.dom = this.getDom()\n\t\tthis.pj = getPj(this)\n\n\t\tthis.lineFxn = line()\n\t\t\t.curve(curveStepAfter)\n\t\t\t.x(c => (c as any).scaledX)\n\t\t\t.y(c => (c as any).scaledY)\n\n\t\tthis.legendRenderer = htmlLegend(this.dom.legendDiv, {\n\t\t\tsettings: {\n\t\t\t\tlegendOrientation: 'vertical'\n\t\t\t},\n\t\t\thandlers: {\n\t\t\t\tlegend: {\n\t\t\t\t\tclick: e => this.legendClick(e.target.__data__, e.clientX, e.clientY)\n\t\t\t\t}\n\t\t\t}\n\t\t})\n\n\t\tthis.hiddenRenderer = htmlLegend(this.dom.hiddenDiv, {\n\t\t\tsettings: {\n\t\t\t\tlegendOrientation: 'vertical'\n\t\t\t},\n\t\t\thandlers: {\n\t\t\t\tlegend: {\n\t\t\t\t\tclick: e => this.legendClick(e.target.__data__, e.clientX, e.clientY)\n\t\t\t\t}\n\t\t\t}\n\t\t})\n\t}\n\n\tgetDom() {\n\t\tconst opts = this.opts\n\t\tconst controls = this.opts.controls ? null : opts.holder.append('div')\n\t\tconst holder = opts.controls ? opts.holder : opts.holder.append('div')\n\t\tconst loadingDiv = holder\n\t\t\t.append('div')\n\t\t\t.style('position', 'absolute')\n\t\t\t.style('display', 'none')\n\t\t\t.style('padding', '20px')\n\t\t\t.html('Loading ...')\n\t\tconst chartsDiv = holder\n\t\t\t.append('div')\n\t\t\t.style('margin', '10px')\n\t\t\t.style('display', 'flex')\n\t\t\t.style('flex-direction', 'row')\n\t\t\t.style('flex-wrap', 'wrap')\n\t\t\t.style('max-width', '100vw')\n\t\tconst dom = {\n\t\t\tloadingDiv,\n\t\t\theader: opts.header,\n\t\t\tcontrols,\n\t\t\tholder,\n\t\t\tchartsDiv,\n\t\t\tlegendDiv: holder.append('div').style('margin', '5px 5px 15px 5px'),\n\t\t\thiddenDiv: holder.append('div').style('margin', '5px 5px 15px 5px'),\n\t\t\ttip: new Menu({ padding: '5px' }),\n\t\t\tlegendTip: new Menu({ padding: '5px' })\n\t\t}\n\n\t\tdom.tip.onHide = () => {\n\t\t\tthis.activeMenu = false\n\t\t}\n\n\t\tif (dom.header) dom.header.html('Survival Plot')\n\t\treturn dom\n\t}\n\n\tasync init() {\n\t\tsetInteractivity(this)\n\t\tsetRenderers(this)\n\t\tawait this.setControls()\n\t}\n\n\tasync setControls() {\n\t\tconst state = this.getState(this.app.getState())\n\t\tconst controlLabels = state.config.controlLabels\n\t\tif (!controlLabels) throw 'controls labels not found'\n\t\tif (this.opts.controls) {\n\t\t\tthis.opts.controls.on('downloadClick.survival', this.download)\n\t\t} else {\n\t\t\tthis.dom.holder.attr('class', 'pp-termdb-plot-viz').style('display', 'inline-block').style('min-width', '300px')\n\n\t\t\tthis.components = {\n\t\t\t\tcontrols: await controlsInit({\n\t\t\t\t\tapp: this.app,\n\t\t\t\t\tid: this.id,\n\t\t\t\t\tholder: this.dom.controls.style('display', 'inline-block'),\n\t\t\t\t\tinputs: [\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\ttype: 'term',\n\t\t\t\t\t\t\tconfigKey: 'term2',\n\t\t\t\t\t\t\tchartType: 'survival',\n\t\t\t\t\t\t\tusecase: { target: 'survival', detail: 'term2' },\n\t\t\t\t\t\t\ttitle: controlLabels.term2.title || controlLabels.term2.label,\n\t\t\t\t\t\t\tlabel: controlLabels.term2.label,\n\t\t\t\t\t\t\tvocabApi: this.app.vocabApi,\n\t\t\t\t\t\t\tnumericEditMenuVersion: ['discrete'],\n\t\t\t\t\t\t\tdefaultQ4fillTW: t0_t2_defaultQ\n\t\t\t\t\t\t},\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\ttype: 'term',\n\t\t\t\t\t\t\tconfigKey: 'term0',\n\t\t\t\t\t\t\tchartType: 'survival',\n\t\t\t\t\t\t\tusecase: { target: 'survival', detail: 'term0' },\n\t\t\t\t\t\t\ttitle: controlLabels.term0.title || controlLabels.term0.label,\n\t\t\t\t\t\t\tlabel: controlLabels.term0.label,\n\t\t\t\t\t\t\tvocabApi: this.app.vocabApi,\n\t\t\t\t\t\t\tnumericEditMenuVersion: ['discrete'],\n\t\t\t\t\t\t\tdefaultQ4fillTW: t0_t2_defaultQ\n\t\t\t\t\t\t},\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\tlabel: 'Chart width',\n\t\t\t\t\t\t\ttype: 'number',\n\t\t\t\t\t\t\tchartType: 'survival',\n\t\t\t\t\t\t\tsettingsKey: 'svgw',\n\t\t\t\t\t\t\ttitle: 'The internal width of the chart plot'\n\t\t\t\t\t\t},\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\tlabel: 'Chart height',\n\t\t\t\t\t\t\ttype: 'number',\n\t\t\t\t\t\t\tchartType: 'survival',\n\t\t\t\t\t\t\tsettingsKey: 'svgh',\n\t\t\t\t\t\t\ttitle: 'The internal height of the chart plot'\n\t\t\t\t\t\t},\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\tlabel: '95% Confidence Interval',\n\t\t\t\t\t\t\tboxLabel: 'Visible',\n\t\t\t\t\t\t\ttype: 'checkbox',\n\t\t\t\t\t\t\tchartType: 'survival',\n\t\t\t\t\t\t\tsettingsKey: 'ciVisible',\n\t\t\t\t\t\t\ttitle: 'Display the 95% confidence interval'\n\t\t\t\t\t\t},\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\tlabel: 'Censored Symbol',\n\t\t\t\t\t\t\ttype: 'radio',\n\t\t\t\t\t\t\tchartType: 'survival',\n\t\t\t\t\t\t\tsettingsKey: 'symbol',\n\t\t\t\t\t\t\toptions: [\n\t\t\t\t\t\t\t\t{ label: 'Tick', value: 'vtick' },\n\t\t\t\t\t\t\t\t{ label: 'X', value: 'x' }\n\t\t\t\t\t\t\t],\n\t\t\t\t\t\t\ttitle: 'Symbol for displaying censored samples'\n\t\t\t\t\t\t},\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\tlabel: 'Survival Time Visualized',\n\t\t\t\t\t\t\ttype: 'number',\n\t\t\t\t\t\t\tchartType: 'survival',\n\t\t\t\t\t\t\tsettingsKey: 'maxTimeToEvent',\n\t\t\t\t\t\t\ttitle:\n\t\t\t\t\t\t\t\t'The maximum time-to-event to be displayed in the survival plot, affects only the visual representation and does not impact other analyses. All available data is still used to compute p-values. If this value is left empty or set to 0, no cutoff will be applied.'\n\t\t\t\t\t\t},\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\tlabel: 'Time Unit',\n\t\t\t\t\t\t\ttype: 'radio',\n\t\t\t\t\t\t\tchartType: 'survival',\n\t\t\t\t\t\t\tsettingsKey: 'timeUnit',\n\t\t\t\t\t\t\toptions: [\n\t\t\t\t\t\t\t\t{ label: 'years', value: 'years' },\n\t\t\t\t\t\t\t\t{ label: 'months', value: 'months' },\n\t\t\t\t\t\t\t\t{ label: 'weeks', value: 'weeks' },\n\t\t\t\t\t\t\t\t{ label: 'days', value: 'days' }\n\t\t\t\t\t\t\t],\n\t\t\t\t\t\t\ttitle: `The unit to display in the x-axis title, like 'years'`\n\t\t\t\t\t\t},\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\tlabel: 'X-axis ticks',\n\t\t\t\t\t\t\ttype: 'text',\n\t\t\t\t\t\t\tchartType: 'survival',\n\t\t\t\t\t\t\tsettingsKey: 'xTickValues',\n\t\t\t\t\t\t\ttitle: `Option to customize the x-axis tick values, enter as comma-separated values. Will be ignored if empty`,\n\t\t\t\t\t\t\tprocessInput: value => (value ? value.split(',').map(Number) : [])\n\t\t\t\t\t\t},\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\tlabel: 'At-risk counts',\n\t\t\t\t\t\t\tboxLabel: 'Visible',\n\t\t\t\t\t\t\ttype: 'checkbox',\n\t\t\t\t\t\t\tchartType: 'survival',\n\t\t\t\t\t\t\tsettingsKey: 'atRiskVisible',\n\t\t\t\t\t\t\ttitle: 'Display the at-risk counts'\n\t\t\t\t\t\t},\n\t\t\t\t\t\t//{label: 'At-risk label offset', type: 'numeric', chartType: 'survival', settingsKey: 'atRiskLabelOffset'},\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\tlabel: 'Default color',\n\t\t\t\t\t\t\ttype: 'color',\n\t\t\t\t\t\t\tchartType: 'survival',\n\t\t\t\t\t\t\tsettingsKey: 'defaultColor',\n\t\t\t\t\t\t\ttitle: 'Default plot color'\n\t\t\t\t\t\t}\n\t\t\t\t\t]\n\t\t\t\t})\n\t\t\t}\n\t\t\tthis.components.controls.on('downloadClick.survival', this.download)\n\t\t}\n\t}\n\n\tgetState(appState) {\n\t\tconst config = appState.plots.find(p => p.id === this.id)\n\t\tif (!config) {\n\t\t\tthrow `No plot with id='${this.id}' found. Did you set this.id before this.api = getComponentApi(this)?`\n\t\t}\n\t\tconst parentConfig = appState.plots.find(p => p.id === this.parentId)\n\t\tconst termfilter = getCombinedTermFilter(appState, config.filter || parentConfig?.filter)\n\n\t\treturn {\n\t\t\tisVisible: config.term.term.type == 'survival' || config.term2?.term.type == 'survival',\n\t\t\tgenome: this.app.vocabApi.vocab.genome,\n\t\t\tdslabel: this.app.vocabApi.vocab.dslabel,\n\t\t\tactiveCohort: appState.activeCohort,\n\t\t\ttermfilter,\n\n\t\t\tconfig: {\n\t\t\t\t// NOTE: will create mutable copies of tw terms in async main() below\n\t\t\t\tterm: config.term,\n\t\t\t\tterm0: config.term0 || null,\n\t\t\t\tterm2: config.term2 || null,\n\t\t\t\tcontrolLabels: config.controlLabels,\n\t\t\t\tsettings: config.settings.survival\n\t\t\t},\n\t\t\ttermdbConfig: appState.termdbConfig\n\t\t}\n\t}\n\n\tasync main() {\n\t\tif (!this.state.isVisible) {\n\t\t\tthis.dom.holder.style('display', 'none')\n\t\t\treturn\n\t\t}\n\n\t\tthis.state.config = await this.getMutableConfig()\n\t\tthis.maySetSandboxHeader()\n\t\tthis.toggleLoadingDiv()\n\n\t\tObject.assign(this.settings, this.state.config.settings)\n\t\tthis.settings.defaultHidden = this.getDefaultHidden()\n\t\tthis.settings.hidden = this.settings.customHidden || this.settings.defaultHidden\n\t\tthis.settings.xTitleLabel = this.getXtitleLabel()\n\t\tconst reqOpts = this.getDataRequestOpts()\n\t\tlet data\n\t\ttry {\n\t\t\t// do not directly set this.serverData to response, since it could be an error\n\t\t\tdata = await this.app.vocabApi.getNestedChartSeriesData(reqOpts, this.api?.getAbortSignal())\n\t\t} catch (e) {\n\t\t\tif (this.app.isAbortError(e)) return\n\t\t\tthrow e\n\t\t}\n\t\tthis.serverData = data\n\t\tthis.toggleLoadingDiv('none')\n\t\tthis.app.vocabApi.syncTermData(this.state.config, data)\n\t\tthis.currData = this.processData(data)\n\t\tthis.refs = data.refs\n\t\tthis.pj.refresh({ data: this.currData })\n\t\tthis.setTerm2Color(this.pj.tree.charts)\n\t\tthis.symbol = this.getSymbol(7) // hardcode the symbol size for now\n\t\tthis.render()\n\t}\n\n\tmaySetSandboxHeader() {\n\t\tif (!this.dom.header) return\n\t\tconst { term, term2 } = this.state.config\n\t\tconst mainTerm = term.term.name\n\t\tif (term2?.type) {\n\t\t\tthis.dom.header.html(`${term2.getTitleText?.() || term2.term.name}  vs ${mainTerm}`)\n\t\t} else {\n\t\t\tthis.dom.header.html(`${mainTerm} plot`)\n\t\t}\n\t}\n\n\t// creates an opts object for the vocabApi.getNestedChartsData()\n\tgetDataRequestOpts() {\n\t\tconst c = this.state.config\n\t\tconst opts: any = {\n\t\t\tchartType: 'survival',\n\t\t\tterm: c.term,\n\t\t\tfilter: this.state.termfilter.filter,\n\t\t\tfilter0: this.state.termfilter.filter0\n\t\t}\n\t\tif (c.term2) {\n\t\t\topts.term2 = c.term2\n\t\t}\n\t\tif (c.term0) opts.term0 = c.term0\n\t\treturn opts\n\t}\n\n\tgetDefaultHidden() {\n\t\tconst hidden: any[] = []\n\t\tconst term2 = this.state.config.term2\n\t\tif (!term2) return hidden\n\t\tconst hiddenValues = term2.q.hiddenValues\n\t\tif (hiddenValues && Object.keys(hiddenValues).length) {\n\t\t\t// term2 has default hidden values\n\t\t\tfor (const k in hiddenValues) {\n\t\t\t\thidden.push(term2.term.values[k].label)\n\t\t\t}\n\t\t}\n\t\treturn hidden\n\t}\n\n\tgetXtitleLabel() {\n\t\tconst termNum = this.state.config.term.term.type == 'survival' ? 'term' : 'term2'\n\t\tconst xUnit = this.settings.timeUnit ? this.settings.timeUnit : this.state.config[termNum].term.unit\n\t\tconst xTitleLabel = `Time to Event (${xUnit})`\n\t\treturn xTitleLabel\n\t}\n\n\tprocessData(data) {\n\t\tthis.uniqueSeriesIds = new Set()\n\t\tconst rows: any[] = []\n\t\tconst estKeys = ['survival', 'lower', 'upper']\n\t\tfor (const d of data.case) {\n\t\t\tconst obj: { [name: string]: any } = {}\n\t\t\tdata.keys.forEach((k, i) => {\n\t\t\t\tobj[k] = estKeys.includes(k) ? Number(d[i]) : d[i]\n\t\t\t})\n\t\t\tobj.time = obj.time * this.getTimeFactor()\n\t\t\trows.push(obj)\n\t\t\tthis.uniqueSeriesIds.add(obj.seriesId)\n\t\t}\n\n\t\t// process statistical tests\n\t\tthis.tests = {}\n\t\tif (data.tests) {\n\t\t\tfor (const chartId in data.tests) {\n\t\t\t\tconst chartTests = data.tests[chartId]\n\t\t\t\tthis.tests[chartId] = []\n\t\t\t\tfor (const test of chartTests) {\n\t\t\t\t\tif (this.settings.hidden.includes(test.series1) || this.settings.hidden.includes(test.series2)) continue // hide tests that contain hidden series\n\t\t\t\t\tthis.tests[chartId].push({\n\t\t\t\t\t\tpvalue: { id: 'pvalue', text: test.pvalue },\n\t\t\t\t\t\tseries1: { id: test.series1 },\n\t\t\t\t\t\tseries2: { id: test.series2 }\n\t\t\t\t\t})\n\t\t\t\t}\n\t\t\t\tif (!this.tests[chartId].length) delete this.tests[chartId]\n\t\t\t}\n\t\t}\n\n\t\treturn rows\n\t}\n\n\t// time factor that converts survival data from default time unit to the current time unit.\n\tgetTimeFactor() {\n\t\tconst numUnitInOneYear = this.settings.numUnitInOneYear || 1\n\t\tconst timeUnit = this.settings.timeUnit || 'years'\n\t\tswitch (timeUnit) {\n\t\t\tcase 'years':\n\t\t\t\treturn (1 / numUnitInOneYear) * 1\n\t\t\tcase 'months':\n\t\t\t\treturn (1 / numUnitInOneYear) * 12\n\t\t\tcase 'weeks':\n\t\t\t\treturn (1 / numUnitInOneYear) * 52\n\t\t\tcase 'days':\n\t\t\t\treturn (1 / numUnitInOneYear) * 365.25\n\t\t\tdefault:\n\t\t\t\tthrow 'unknown time Unit for survival data'\n\t\t}\n\t}\n\n\tsetTerm2Color(charts) {\n\t\tif (!charts) return\n\t\tconst config = this.state.config\n\t\t// color override via legend clicks is saved in term2.values, not by directly editing term2.term.values\n\t\tconst t2values = copyMerge({}, config.term2?.term?.values || {}, config.term2?.values || {})\n\t\tconst values = (this.refs.bins[2] && [this.refs.bins[2]]) || Object.values(t2values)\n\t\tlet t2groups\n\t\tif (config.term2?.q.type == 'predefined-groupset' || config.term2?.q.type == 'custom-groupset') {\n\t\t\tconst groupset =\n\t\t\t\tconfig.term2.q.type == 'predefined-groupset'\n\t\t\t\t\t? config.term2.term.groupsetting.lst[config.term2.q.predefined_groupset_idx]\n\t\t\t\t\t: config.term2.q.customset\n\t\t\tif (!groupset) throw 'groupset is missing'\n\t\t\tt2groups = groupset.groups\n\t\t}\n\t\tthis.term2toColor = {}\n\t\tthis.colorScale = this.uniqueSeriesIds.size < 11 ? scaleOrdinal(schemeCategory10) : scaleOrdinal(schemeCategory20)\n\t\tconst legendItems: any[] = []\n\t\tfor (const chart of charts) {\n\t\t\tfor (const series of chart.serieses) {\n\t\t\t\tlet color\n\t\t\t\t// color override via legend clicks is saved in t2values, does not edit term.values or group.color directly\n\t\t\t\tconst v = values.find(\n\t\t\t\t\tv =>\n\t\t\t\t\t\tv.seriesId === series.seriesId ||\n\t\t\t\t\t\tv.key === series.seriesId ||\n\t\t\t\t\t\tv.name === series.seriesId ||\n\t\t\t\t\t\tv.label === series.seriesId\n\t\t\t\t)\n\t\t\t\tcolor = v?.color\n\t\t\t\tif (!color && t2groups?.length) {\n\t\t\t\t\tconst group = t2groups.find(g => g.name == series.seriesId)\n\t\t\t\t\tcolor = group?.color\n\t\t\t\t\t// quick fix to make WT gray darker to pass Section 508 contrast requirement;\n\t\t\t\t\t// doing this in common.js makes this gray in all tools darker and conflicts\n\t\t\t\t\t// with other mclass colors like in-frame insertion, also visually overwhelming\n\t\t\t\t\t// in GDC oncomatrix\n\t\t\t\t\tif (color === '#D3D3D3' && group?.filter?.lst?.find(f => f?.type === 'tvs' && f.tvs.genotype == 'wt'))\n\t\t\t\t\t\tcolor = 'rgb(105,105,105)'\n\t\t\t\t}\n\t\t\t\tconst orig = color || (series.seriesId == '' ? this.settings.defaultColor : this.colorScale(series.seriesId))\n\t\t\t\tconst _rgb = rgb(orig)\n\t\t\t\tconst adjusted = _rgb.toString()\n\t\t\t\tconst c = { orig, rgb: _rgb, adjusted, hex: rgb2hex(adjusted) }\n\t\t\t\tthis.term2toColor[series.seriesId] = c\n\n\t\t\t\tif (!legendItems.find(d => d.seriesId == series.seriesId)) {\n\t\t\t\t\tlegendItems.push({\n\t\t\t\t\t\tkey: series.seriesId,\n\t\t\t\t\t\tseriesId: series.seriesId,\n\t\t\t\t\t\ttext: series.seriesLabel,\n\t\t\t\t\t\tcolor: this.term2toColor[series.seriesId].adjusted,\n\t\t\t\t\t\tisHidden: this.settings.hidden.includes(series.seriesId)\n\t\t\t\t\t})\n\t\t\t\t}\n\t\t\t}\n\t\t}\n\t\tif (this.refs.orderedKeys) {\n\t\t\tconst s = this.refs.orderedKeys.series\n\t\t\tlegendItems.sort((a, b) => s.indexOf(a.seriesId) - s.indexOf(b.seriesId))\n\t\t}\n\n\t\tif (!this.legendOrder.length) {\n\t\t\tthis.legendOrder = legendItems.map(item => item.seriesId)\n\t\t} else {\n\t\t\tlegendItems.sort((a, b) => this.legendOrder.indexOf(a.seriesId) - this.legendOrder.indexOf(b.seriesId))\n\t\t}\n\n\t\tif ((config.term.term.type == 'survival' || config.term2) && legendItems.length) {\n\t\t\tconst termNum = config.term.term.type == 'survival' && config.term2 ? 'term2' : 'term'\n\t\t\tthis.legendData = [\n\t\t\t\t{\n\t\t\t\t\tname: config[termNum].term.name,\n\t\t\t\t\titems: legendItems.filter(s => !s.isHidden)\n\t\t\t\t}\n\t\t\t]\n\n\t\t\tthis.hiddenData = [\n\t\t\t\t{\n\t\t\t\t\tname: `<span style='color:#aaa; font-weight:400'><span>Hidden categories</span><span style='font-size:0.8rem'> CLICK TO SHOW</span></span>`,\n\t\t\t\t\titems: legendItems.filter(s => s.isHidden).map(item => Object.assign({}, item, { isHidden: false }))\n\t\t\t\t}\n\t\t\t]\n\t\t} else {\n\t\t\tthis.legendData = []\n\t\t}\n\t\tfor (const chartId in this.tests) {\n\t\t\tconst chartTests = this.tests[chartId]\n\t\t\tfor (const test of chartTests) {\n\t\t\t\tfor (const key in test) {\n\t\t\t\t\tif (key == 'pvalue') {\n\t\t\t\t\t\t// p-value of test\n\t\t\t\t\t\ttest[key].color = '#000'\n\t\t\t\t\t} else {\n\t\t\t\t\t\t// series of test\n\t\t\t\t\t\tconst item = legendItems.find(item => item.seriesId == test[key].id)\n\t\t\t\t\t\ttest[key].color = item.color\n\t\t\t\t\t\ttest[key].text = item.text\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t}\n\t\t}\n\t}\n\n\t// helper so that 'Loading...' does not flash when not needed\n\ttoggleLoadingDiv(display = '') {\n\t\tif (display != 'none') {\n\t\t\tthis.dom.loadingDiv\n\t\t\t\t.style('opacity', 0)\n\t\t\t\t.style('display', display)\n\t\t\t\t.transition()\n\t\t\t\t.duration('loadingWait' in this ? this.loadingWait : 0)\n\t\t\t\t.style('opacity', 1)\n\t\t} else {\n\t\t\tthis.dom.loadingDiv.style('display', display)\n\t\t}\n\t\t// do not transition on initial chart load\n\t\tthis.loadingWait = 1000\n\t}\n}\n\nexport const survivalInit = getCompInit(TdbSurvival)\n// this alias will allow abstracted dynamic imports\nexport const componentInit = survivalInit\n\nfunction setRenderers(self) {\n\tself.render = function () {\n\t\tconst data = self.pj.tree.charts || [{ chartId: 'No survival data' }]\n\t\tconst chartDivs = self.dom.chartsDiv.selectAll('.pp-survival-chart').data(data, d => d.chartId)\n\t\tchartDivs.exit().remove()\n\t\tchartDivs.each(self.updateCharts)\n\t\tchartDivs.enter().each(self.addCharts)\n\n\t\tself.dom.holder.style('display', 'inline-block')\n\t\tself.dom.chartsDiv.on('mouseover', self.mouseover).on('mouseout', self.mouseout)\n\n\t\tself.legendRenderer(self.settings.atRiskVisible ? [] : self.legendData)\n\t\tif (!self.hiddenData?.[0]?.items.length) self.dom.hiddenDiv.style('display', 'none')\n\t\telse {\n\t\t\tself.dom.hiddenDiv.style('display', '')\n\t\t\tself.hiddenRenderer(self.hiddenData)\n\t\t}\n\t}\n\n\tconst updateHiddenPvalues = hiddenPvalues => {\n\t\tself.app.dispatch({\n\t\t\ttype: 'plot_edit',\n\t\t\tid: self.id,\n\t\t\tconfig: {\n\t\t\t\tsettings: {\n\t\t\t\t\tsurvival: {\n\t\t\t\t\t\thiddenPvalues\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t}\n\t\t})\n\t}\n\n\tconst setActiveMenu = bool => (self.activeMenu = bool)\n\n\tself.addCharts = function (chart) {\n\t\tconst s = self.settings\n\t\tsetVisibleSerieses(chart, s)\n\n\t\tconst div = select(this)\n\t\t\t.append('div')\n\t\t\t.attr('class', 'pp-survival-chart')\n\t\t\t.style('opacity', chart.serieses ? 0 : 1) // if the data can be plotted, slowly reveal plot\n\t\t\t.style('width', 'fit-content')\n\t\t\t.style('display', 'inline-block')\n\t\t\t.style('margin', s.chartMargin + 'px')\n\t\t\t.style('padding', '10px')\n\t\t\t.style('top', 0)\n\t\t\t.style('left', 0)\n\t\t\t.style('text-align', 'left')\n\t\t\t.style('vertical-align', 'top')\n\n\t\tdiv\n\t\t\t.append('div')\n\t\t\t.style('width', s.svgw + 50 + 'px')\n\t\t\t.style('height', s.chartTitleDivHt + 'px')\n\t\t\t.style('text-align', 'center')\n\t\t\t.style('font-weight', '600')\n\t\t\t.style('margin', '5px')\n\t\t\t.append('div')\n\t\t\t.attr('class', 'sjpp-survival-title')\n\t\t\t.attr('data-testid', 'sjpp-survival-plotTitle')\n\t\t\t.style('display', 'inline-block')\n\t\t\t.style('width', 'fit-content')\n\t\t\t.datum(chart)\n\t\t\t.html(chart => chart.chartId)\n\n\t\tif (chart.serieses) {\n\t\t\tconst svg = div.append('svg').attr('class', 'pp-survival-svg')\n\t\t\trenderSVG(svg, chart, s, 0)\n\n\t\t\tdiv.transition().duration(s.duration).style('opacity', 1)\n\n\t\t\t// div for chart-specific legends\n\t\t\tdiv\n\t\t\t\t.append('div')\n\t\t\t\t.attr('class', 'pp-survival-chartLegends')\n\t\t\t\t.style('vertical-align', 'top')\n\t\t\t\t.style('margin', '10px 10px 10px 80px')\n\t\t\t\t.style('display', 'none')\n\n\t\t\t// p-values legend\n\t\t\tif (self.tests && chart.rawChartId in self.tests) {\n\t\t\t\tconst holder = div.select('.pp-survival-chartLegends').style('display', 'inline-block').append('div')\n\t\t\t\trenderPvalues({\n\t\t\t\t\ttitle: 'Group comparisons (log-rank test)',\n\t\t\t\t\tholder,\n\t\t\t\t\tplot: 'survival',\n\t\t\t\t\ttests: self.tests[chart.rawChartId],\n\t\t\t\t\ts,\n\t\t\t\t\tbins: self.refs.bins,\n\t\t\t\t\ttip: self.app.tip,\n\t\t\t\t\tsetActiveMenu,\n\t\t\t\t\tupdateHiddenPvalues\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t}\n\n\tfunction setVisibleSerieses(chart, s) {\n\t\tchart.visibleSerieses = chart.serieses?.filter(series => !s.hidden.includes(series.seriesId)) || []\n\t\tconst maxSeriesLabelLen = chart.visibleSerieses.reduce(\n\t\t\t(maxlen, a) => (a.seriesLabel && a.seriesLabel.length > maxlen ? a.seriesLabel.length : maxlen),\n\t\t\t0\n\t\t)\n\t\tchart.atRiskLabelWidth = s.atRiskVisible\n\t\t\t? maxSeriesLabelLen * (s.axisTitleFontSize - 2) * 0.4 + s.atRiskLabelOffset\n\t\t\t: 0\n\t}\n\n\tself.updateCharts = function (chart) {\n\t\tif (!chart.serieses) return\n\t\tconst s = self.settings\n\t\tsetVisibleSerieses(chart, s)\n\n\t\tconst div = select(this)\n\t\tdiv.transition().duration(s.duration).style('width', 'fit-content')\n\n\t\tdiv\n\t\t\t.select('.sjpp-survival-title')\n\t\t\t.style('width', s.svgw + 50)\n\t\t\t.style('height', s.chartTitleDivHt + 'px')\n\t\t\t.datum(chart.chartId)\n\t\t\t.html(chart.chartId)\n\n\t\tdiv.selectAll('.sjpp-lock-icon').style('display', s.scale == 'byChart' ? 'block' : 'none')\n\n\t\tdiv.selectAll('.sjpp-unlock-icon').style('display', s.scale == 'byChart' ? 'none' : 'block')\n\n\t\trenderSVG(div.select('svg'), chart, s, s.duration)\n\n\t\t// div for chart-specific legends\n\t\tdiv.select('.pp-survival-chartLegends').selectAll('*').remove()\n\n\t\t// p-values legend\n\t\tif (self.tests && chart.rawChartId in self.tests) {\n\t\t\tconst holder = div.select('.pp-survival-chartLegends').style('display', 'inline-block').append('div')\n\t\t\trenderPvalues({\n\t\t\t\ttitle: 'Group comparisons (log-rank test)',\n\t\t\t\tholder,\n\t\t\t\tplot: 'survival',\n\t\t\t\ttests: self.tests[chart.rawChartId],\n\t\t\t\ts,\n\t\t\t\tbins: self.refs.bins,\n\t\t\t\ttip: self.app.tip,\n\t\t\t\tsetActiveMenu,\n\t\t\t\tupdateHiddenPvalues\n\t\t\t})\n\t\t}\n\t}\n\n\tfunction renderSVG(svg, chart, s, duration) {\n\t\tchart.svg = svg\n\t\tconst extraHeight = s.atRiskVisible\n\t\t\t? s.axisTitleFontSize + 4 + chart.visibleSerieses.length * 2 * (s.axisTitleFontSize + 4)\n\t\t\t: 0\n\n\t\tsvg\n\t\t\t.transition()\n\t\t\t.duration(duration)\n\t\t\t.attr('width', s.svgw + chart.atRiskLabelWidth)\n\t\t\t.attr('height', s.svgh + extraHeight)\n\t\t\t.style('overflow', 'visible')\n\t\t\t.style('padding-left', '20px')\n\n\t\t/* eslint-disable */\n\t\tconst [mainG, seriesesG, axisG, xAxis, yAxis, xTitle, yTitle, atRiskG, plotRect] = getSvgSubElems(svg)\n\t\t/* eslint-enable */\n\t\tconst xOffset = chart.atRiskLabelWidth + s.svgPadding.left + 70 //adding 70 avoids clipping of the svg when downloading\n\t\tmainG.attr('transform', 'translate(' + xOffset + ',' + s.svgPadding.top + ')')\n\n\t\tconst serieses = seriesesG\n\t\t\t.selectAll('.sjpp-survival-series')\n\t\t\t.data(chart.visibleSerieses, d => (d && d[0] ? d[0].seriesId : ''))\n\n\t\tserieses.exit().remove()\n\t\tserieses.each(function (this: HTMLElement, series, i) {\n\t\t\trenderSeries(select(this), chart, series, i, s)\n\t\t})\n\t\tserieses\n\t\t\t.enter()\n\t\t\t.append('g')\n\t\t\t.attr('class', 'sjpp-survival-series')\n\t\t\t.each(function (this: HTMLElement, series, i) {\n\t\t\t\trenderSeries(select(this), chart, series, i, s)\n\t\t\t})\n\n\t\trenderAxes(xAxis, xTitle, yAxis, yTitle, s, chart)\n\t\trenderAtRiskG({\n\t\t\tg: atRiskG,\n\t\t\ts,\n\t\t\tchart,\n\t\t\torder: self.legendOrder,\n\t\t\tterm2toColor: self.term2toColor,\n\t\t\tonSerieClick: self.legendClick\n\t\t})\n\n\t\tplotRect\n\t\t\t.attr('x', 0) //s.svgPadding.left) //s.svgh - s.svgPadding.top - s.svgPadding.bottom + 5)\n\t\t\t.attr('width', s.svgw - s.svgPadding.left - s.svgPadding.right)\n\t\t\t.attr('y', 0) //s.svgPadding.top) // - s.svgPadding.bottom + 5)\n\t\t\t.attr('height', s.svgh - s.svgPadding.top - s.svgPadding.bottom + s.xAxisOffset)\n\n\t\tsvg.seriesTip.update({\n\t\t\txScale: chart.xScale,\n\t\t\txTitleLabel: s.xTitleLabel,\n\t\t\tdecimals: s.seriesTipDecimals,\n\t\t\tserieses: chart.visibleSerieses.map(s => {\n\t\t\t\tconst seriesLabel = `${s.seriesLabel || 'Probability'}:`\n\t\t\t\tconst color = self.term2toColor[s.seriesId].adjusted || '#000'\n\t\t\t\treturn {\n\t\t\t\t\tdata: s.data.map(d => {\n\t\t\t\t\t\treturn {\n\t\t\t\t\t\t\tx: d.x,\n\t\t\t\t\t\t\thtml:\n\t\t\t\t\t\t\t\t`<span style='color: ${color}'>` +\n\t\t\t\t\t\t\t\t`${seriesLabel} ${(100 * d.y).toFixed(2)}% (${(100 * d.lower).toFixed(2)} - ${(100 * d.upper).toFixed(\n\t\t\t\t\t\t\t\t\t2\n\t\t\t\t\t\t\t\t)})` +\n\t\t\t\t\t\t\t\t`</span>`\n\t\t\t\t\t\t}\n\t\t\t\t\t})\n\t\t\t\t}\n\t\t\t})\n\t\t})\n\t}\n\n\tfunction getSvgSubElems(svg) {\n\t\tlet mainG, seriesesG, axisG, xAxis, yAxis, xTitle, yTitle, atRiskG, plotRect, line\n\t\tif (!svg.select('.sjpp-survival-mainG').size()) {\n\t\t\tmainG = svg.append('g').attr('class', 'sjpp-survival-mainG')\n\t\t\tseriesesG = mainG.append('g').attr('class', 'sjpcb-survival-seriesesG')\n\t\t\taxisG = mainG.append('g').attr('class', 'sjpp-survival-axis')\n\t\t\txAxis = axisG.append('g').attr('class', 'sjpp-survival-x-axis')\n\t\t\tyAxis = axisG.append('g').attr('class', 'sjpp-survival-y-axis')\n\t\t\txTitle = axisG.append('g').attr('class', 'sjpp-survival-x-title')\n\t\t\tyTitle = axisG.append('g').attr('class', 'sjpp-survival-y-title')\n\t\t\tatRiskG = mainG.append('g').attr('class', 'sjpp-survival-atrisk')\n\t\t\tline = mainG\n\t\t\t\t.append('line')\n\t\t\t\t.attr('class', 'sjpcb-plot-tip-line')\n\t\t\t\t.attr('stroke', '#000')\n\t\t\t\t.attr('stroke-width', '1px')\n\t\t\tplotRect = mainG.append('rect').attr('class', 'sjpcb-plot-tip-rect').style('fill', 'transparent')\n\t\t} else {\n\t\t\tmainG = svg.select('.sjpp-survival-mainG')\n\t\t\tseriesesG = mainG.select('.sjpcb-survival-seriesesG')\n\t\t\taxisG = mainG.select('.sjpp-survival-axis')\n\t\t\txAxis = axisG.select('.sjpp-survival-x-axis')\n\t\t\tyAxis = axisG.select('.sjpp-survival-y-axis')\n\t\t\txTitle = axisG.select('.sjpp-survival-x-title')\n\t\t\tyTitle = axisG.select('.sjpp-survival-y-title')\n\t\t\tatRiskG = mainG.select('.sjpp-survival-atrisk')\n\t\t\tplotRect = mainG.select('.sjpcb-plot-tip-rect')\n\t\t\tline = mainG.select('.sjpcb-plot-tip-line')\n\t\t}\n\n\t\tif (!svg.seriesTip) {\n\t\t\tsvg.seriesTip = getSeriesTip(line, plotRect, self.dom.tip)\n\t\t}\n\n\t\treturn [mainG, seriesesG, axisG, xAxis, yAxis, xTitle, yTitle, atRiskG, plotRect]\n\t}\n\n\tfunction renderSeries(g, chart, series, i, s) {\n\t\t// do not show samples with time to event larger than maxTimeToEvent\n\t\tlet processedData = series.data\n\t\tif (s.maxTimeToEvent) {\n\t\t\tprocessedData = series.data.filter(d => d.x <= s.maxTimeToEvent)\n\t\t}\n\t\t// todo: allow update of exiting path instead of replacing\n\t\tg.selectAll('path').remove()\n\t\tg.append('path')\n\t\t\t.attr(\n\t\t\t\t'd',\n\t\t\t\tarea()\n\t\t\t\t\t.curve(curveStepAfter)\n\t\t\t\t\t.x(c => (c as any).scaledX)\n\t\t\t\t\t.y0(c => (c as any).scaledY[1])\n\t\t\t\t\t.y1(c => (c as any).scaledY[2])(processedData)\n\t\t\t)\n\t\t\t.style('display', s.ciVisible ? '' : 'none')\n\t\t\t.style('fill', self.term2toColor[series.seriesId].adjusted)\n\t\t\t.style('opacity', '0.15')\n\t\t\t.style('stroke', 'none')\n\n\t\trenderSubseries(\n\t\t\ts,\n\t\t\tg,\n\t\t\tprocessedData.map(d => {\n\t\t\t\treturn {\n\t\t\t\t\tseriesId: d.seriesId,\n\t\t\t\t\tx: d.x,\n\t\t\t\t\ty: d.y,\n\t\t\t\t\tscaledX: d.scaledX,\n\t\t\t\t\tscaledY: d.scaledY[0],\n\t\t\t\t\tseriesName: 'survival',\n\t\t\t\t\tseriesLabel: series.seriesLabel,\n\t\t\t\t\tnevent: d.nevent,\n\t\t\t\t\tncensor: d.ncensor,\n\t\t\t\t\tnrisk: d.nrisk\n\t\t\t\t}\n\t\t\t})\n\t\t)\n\n\t\trenderSubseries(\n\t\t\ts,\n\t\t\tg.append('g'),\n\t\t\tprocessedData.map(d => {\n\t\t\t\treturn {\n\t\t\t\t\tseriesId: d.seriesId,\n\t\t\t\t\tx: d.x,\n\t\t\t\t\ty: d.lower,\n\t\t\t\t\tscaledX: d.scaledX,\n\t\t\t\t\tscaledY: d.scaledY[1],\n\t\t\t\t\tseriesName: 'lower',\n\t\t\t\t\tseriesLabel: series.seriesLabel,\n\t\t\t\t\tnevent: d.nevent,\n\t\t\t\t\tncensor: 0, // no censor marks for lower CI\n\t\t\t\t\tnrisk: d.nrisk\n\t\t\t\t}\n\t\t\t})\n\t\t)\n\n\t\trenderSubseries(\n\t\t\ts,\n\t\t\tg.append('g'),\n\t\t\tprocessedData.map(d => {\n\t\t\t\treturn {\n\t\t\t\t\tseriesId: d.seriesId,\n\t\t\t\t\tx: d.x,\n\t\t\t\t\ty: d.upper,\n\t\t\t\t\tscaledX: d.scaledX,\n\t\t\t\t\tscaledY: d.scaledY[2],\n\t\t\t\t\tseriesName: 'upper', // no censor marks for upper CI\n\t\t\t\t\tseriesLabel: series.seriesLabel,\n\t\t\t\t\tnevent: d.nevent,\n\t\t\t\t\tncensor: 0,\n\t\t\t\t\tnrisk: d.nrisk\n\t\t\t\t}\n\t\t\t})\n\t\t)\n\t}\n\n\tfunction renderSubseries(s, g, data) {\n\t\t// todo: allow update of exiting g's instead of replacing\n\t\tg.selectAll('g').remove()\n\n\t\tconst lineData = data.filter((d, i) => i === 0 || d.nevent || i === data.length - 1)\n\t\tconst censoredData = data.filter(d => d.ncensor)\n\n\t\tconst seriesName = data[0].seriesName\n\t\tconst color = self.term2toColor[data[0].seriesId].adjusted\n\t\tif (seriesName == 'survival') {\n\t\t\tg.append('path')\n\t\t\t\t.attr('d', self.lineFxn(lineData))\n\t\t\t\t.style('fill', 'none')\n\t\t\t\t.style('stroke', color)\n\t\t\t\t.style('opacity', 1)\n\t\t\t\t.style('stroke-opacity', 1)\n\t\t}\n\n\t\tconst subg1 = g.append('g').attr('class', 'sjpp-survival-censored')\n\t\tconst censored = subg1.selectAll('.sjpp-survival-censored-x').data(censoredData, d => d.x)\n\n\t\tcensored.exit().remove()\n\n\t\tcensored\n\t\t\t.attr('transform', c => `translate(${c.scaledX},${c.scaledY})`)\n\t\t\t.style('stroke', color)\n\t\t\t.style('display', '')\n\n\t\tcensored\n\t\t\t.enter()\n\t\t\t.append('path')\n\t\t\t.attr('class', 'sjpp-survival-censored-x')\n\t\t\t.attr('transform', c => `translate(${c.scaledX},${c.scaledY})`)\n\t\t\t.attr('d', self.symbol)\n\t\t\t.style('fill', 'transparent')\n\t\t\t.style('fill-opacity', s.fillOpacity)\n\t\t\t.style('stroke', color)\n\t\t\t.style('display', '')\n\t}\n\n\tfunction renderAxes(xAxis, xTitle, yAxis, yTitle, s, chart) {\n\t\tlet xTicks\n\t\tif (s.xTickValues?.length) {\n\t\t\t// xTicksValues should not be larger than maxTimeToEvent\n\t\t\tchart.xTickValues = s.xTickValues.filter(\n\t\t\t\tv => v === 0 || (v >= chart.xMin && v <= Math.min(s.maxTimeToEvent || chart.xMax, chart.xMax))\n\t\t\t)\n\t\t\txTicks = axisBottom(chart.xScale).tickValues(chart.xTickValues)\n\t\t} else {\n\t\t\tchart.xTickValues = []\n\t\t\txTicks = axisBottom(chart.xScale)\n\t\t\t\t.ticks(4)\n\t\t\t\t.tickFormat((xval: any) => {\n\t\t\t\t\tchart.xTickValues.push(xval)\n\t\t\t\t\treturn xval\n\t\t\t\t})\n\t\t}\n\n\t\t// without this pixel offset, the axes and data are slightly misaligned\n\t\t// this could be because the axes have a 0.5 offset in their path,\n\t\t// for example: <path class=\"domain\" stroke=\"#000\" d=\"M0.5,6V0.5H325.5V6\"></path>\n\t\tconst pixelOffset = -0.5\n\n\t\txAxis\n\t\t\t.attr(\n\t\t\t\t'transform',\n\t\t\t\t`translate(${pixelOffset}, ${s.svgh - s.svgPadding.top - s.svgPadding.bottom + s.xAxisOffset + pixelOffset})`\n\t\t\t)\n\t\t\t.call(xTicks)\n\n\t\tyAxis\n\t\t\t.attr('transform', `translate(${s.yAxisOffset + pixelOffset}, ${pixelOffset})`)\n\t\t\t.call(axisLeft(scaleLinear().domain(chart.yScale.domain()).range(chart.yScale.range())).ticks(5))\n\n\t\txTitle.select('text, title').remove()\n\t\txTitle\n\t\t\t.attr(\n\t\t\t\t'transform',\n\t\t\t\t'translate(' +\n\t\t\t\t\t(s.svgw - s.svgPadding.left - s.svgPadding.right) / 2 +\n\t\t\t\t\t',' +\n\t\t\t\t\t(s.svgh - s.axisTitleFontSize - 4) +\n\t\t\t\t\t')'\n\t\t\t)\n\t\t\t.append('text')\n\t\t\t.style('text-anchor', 'middle')\n\t\t\t.style('font-size', s.axisTitleFontSize + 'px')\n\t\t\t.text(s.xTitleLabel)\n\n\t\tconst yTitleLabel = 'Probability of Survival'\n\t\tyTitle.select('text, title').remove()\n\t\tyTitle\n\t\t\t.attr(\n\t\t\t\t'transform',\n\t\t\t\t'translate(' +\n\t\t\t\t\t(-s.svgPadding.left / 2 - s.axisTitleFontSize) +\n\t\t\t\t\t',' +\n\t\t\t\t\t(s.svgh - s.svgPadding.top - s.svgPadding.bottom) / 2 +\n\t\t\t\t\t')rotate(-90)'\n\t\t\t)\n\t\t\t.append('text')\n\t\t\t.style('text-anchor', 'middle')\n\t\t\t.style('font-size', s.axisTitleFontSize + 'px')\n\t\t\t.text(yTitleLabel)\n\t}\n\n\tself.getSymbol = function (size) {\n\t\tconst s = size,\n\t\t\th = s / 2\n\n\t\tswitch (self.settings.symbol) {\n\t\t\tcase 'x':\n\t\t\t\treturn `M -${h},-${h} l ${s},${s} M ${h},-${h} l -${s},${s}`\n\n\t\t\tcase 'vtick':\n\t\t\t\treturn `M 0,-${h} L 0,${h}`\n\n\t\t\tdefault:\n\t\t\t\tthrow `Unrecognized survival plot symbol='${self.settings.symbol}'`\n\t\t}\n\t}\n}\n\nfunction setInteractivity(self) {\n\tself.download = function (event) {\n\t\tconst charts = self.getChartImages()\n\t\tconst menu = new DownloadMenu(charts, self.state.config.term.term.name)\n\t\tmenu.show(event.clientX, event.clientY, event.target)\n\t}\n\n\tself.getChartImages = function () {\n\t\tconst charts: any[] = []\n\t\tif (!self.pj.tree.charts) return charts // no charts to download\n\t\tfor (const chart of self.pj.tree.charts) {\n\t\t\tcharts.push({ name: chart.chartId, svg: chart.svg })\n\t\t}\n\t\treturn charts\n\t}\n\n\t// The logic is replaced by the downloadMenu SVG option\n\t// self.download = function () {\n\t// \tif (!self.state) return\n\t// \tdownloadChart(\n\t// \t\tself.dom.chartsDiv.selectAll('.sjpp-survival-mainG'),\n\t// \t\t'Survival_Plot',\n\t// \t\tself.dom.chartsDiv.select('.pp-survival-chart').node()\n\t// \t)\n\t// }\n\n\tself.mouseover = function () {}\n\n\tself.mouseout = function () {\n\t\tif (self.activeMenu) return\n\t\tself.app.tip.hide()\n\t}\n\n\tself.legendClick = function (d, x, y) {\n\t\tif (d === undefined) return\n\t\tconst hidden = self.settings.hidden.slice()\n\t\tconst i = hidden.indexOf(d.seriesId)\n\t\tif (i == -1) {\n\t\t\thidden.push(d.seriesId)\n\t\t\tself.showLegendItemMenu(d, hidden, x, y)\n\t\t} else {\n\t\t\thidden.splice(i, 1)\n\t\t\tself.app.dispatch({\n\t\t\t\ttype: 'plot_edit',\n\t\t\t\tid: self.id,\n\t\t\t\tconfig: {\n\t\t\t\t\tsettings: {\n\t\t\t\t\t\tsurvival: {\n\t\t\t\t\t\t\tcustomHidden: hidden\n\t\t\t\t\t\t}\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t})\n\t\t}\n\t}\n\n\tself.showLegendItemMenu = function (d, hidden, x, y) {\n\t\tconst term2 = self.state.config.term2?.term || null\n\t\tconst seriesLabel = term2?.values?.[d.seriesId]?.label || d.seriesId\n\n\t\tconst header = `<div style='padding-bottom:8px'><b>${seriesLabel}</b></div>`\n\t\tconst data = d.seriesId || d.seriesId === 0 ? d : { seriesId: d.id, dataId: d.dataId }\n\t\tif (!data.seriesId && !data.dataId) {\n\t\t\tif (!term2) {\n\t\t\t\tconst label = self.dom.legendTip.clear().d.append('div').html('Edit color: ')\n\t\t\t\tconst input = label\n\t\t\t\t\t.append('input')\n\t\t\t\t\t.attr('type', 'color')\n\t\t\t\t\t.attr('value', self.settings.defaultColor)\n\t\t\t\t\t.on('change', () => self.adjustColor(input.property('value'), d))\n\t\t\t\tself.dom.legendTip.show(x, y)\n\t\t\t}\n\t\t\treturn\n\t\t}\n\n\t\tconst options: any[] = []\n\t\toptions.push({\n\t\t\tlabel: 'Hide',\n\t\t\tcallback: () => {\n\t\t\t\tmenu.hide()\n\t\t\t\tself.app.dispatch({\n\t\t\t\t\ttype: 'plot_edit',\n\t\t\t\t\tid: self.id,\n\t\t\t\t\tconfig: {\n\t\t\t\t\t\tsettings: {\n\t\t\t\t\t\t\tsurvival: {\n\t\t\t\t\t\t\t\tcustomHidden: hidden\n\t\t\t\t\t\t\t}\n\t\t\t\t\t\t}\n\t\t\t\t\t}\n\t\t\t\t})\n\t\t\t}\n\t\t})\n\n\t\tif (self.legendData[0]?.items.length > 1) {\n\t\t\toptions.push({\n\t\t\t\tlabel: 'Move&nbsp;',\n\t\t\t\tsetInput: holder => {\n\t\t\t\t\tconst legendIndex = self.legendOrder.indexOf(d.seriesId)\n\t\t\t\t\tif (legendIndex != 0)\n\t\t\t\t\t\tholder\n\t\t\t\t\t\t\t.append('button')\n\t\t\t\t\t\t\t.html('up')\n\t\t\t\t\t\t\t.on('click', () => {\n\t\t\t\t\t\t\t\tmenu.hide()\n\t\t\t\t\t\t\t\tself.adjustLegendOrder(d, -1)\n\t\t\t\t\t\t\t})\n\t\t\t\t\tif (legendIndex < self.legendData[0]?.items.length - 1)\n\t\t\t\t\t\tholder\n\t\t\t\t\t\t\t.append('button')\n\t\t\t\t\t\t\t.html('down')\n\t\t\t\t\t\t\t.on('click', () => {\n\t\t\t\t\t\t\t\tmenu.hide()\n\t\t\t\t\t\t\t\tself.adjustLegendOrder(d, 1)\n\t\t\t\t\t\t\t})\n\t\t\t\t}\n\t\t\t})\n\t\t}\n\n\t\toptions.push({\n\t\t\t//label: 'Color',\n\t\t\t//callback: d => {}\n\t\t\tsetInput: holder => {\n\t\t\t\tconst label = holder.append('div')\n\t\t\t\tlabel.html('Edit color: ')\n\t\t\t\tconst input = label\n\t\t\t\t\t.append('input')\n\t\t\t\t\t.attr('type', 'color')\n\t\t\t\t\t.attr('value', self.term2toColor[d.seriesId].hex)\n\t\t\t\t\t.on('change', () => self.adjustColor(input.property('value'), d))\n\t\t\t}\n\t\t})\n\n\t\tif (!options.length) return\n\t\tconst menu = self.dom.legendTip.clear()\n\t\tmenu.d.append('div').html(header)\n\t\tmenu.d\n\t\t\t.append('div')\n\t\t\t.selectAll('div')\n\t\t\t.data(options)\n\t\t\t.enter()\n\t\t\t.append('div')\n\t\t\t.attr('class', d => (d.label == 'Hide' ? 'sja_menuoption' : 'sja_menuoption_not_interactive'))\n\t\t\t.on('click', (event, c) => {\n\t\t\t\tif (c.setInput) return\n\t\t\t\tself.app.tip.hide()\n\t\t\t\tc.callback(d)\n\t\t\t})\n\n\t\t\t.each(function (this: HTMLElement, d) {\n\t\t\t\tconst div = select(this)\n\t\t\t\tif (d.label) div.append('div').style('display', 'inline-block').html(d.label)\n\t\t\t\tif (d.setInput)\n\t\t\t\t\td.setInput(\n\t\t\t\t\t\tdiv.append('div').style('display', 'inline-block')\n\t\t\t\t\t\t//.style('margin-left', '10px')\n\t\t\t\t\t)\n\t\t\t})\n\n\t\tmenu.show(x, y)\n\t}\n\n\tself.adjustLegendOrder = (d, increment) => {\n\t\tconst oldIndex = self.legendOrder.indexOf(d.seriesId)\n\t\tif (oldIndex == -1) return\n\t\tlet newIndex = oldIndex + increment\n\t\t// clamp to array bounds\n\t\tnewIndex = Math.max(0, Math.min(self.legendOrder.length - 1, newIndex))\n\t\t// remove item\n\t\tself.legendOrder.splice(oldIndex, 1)\n\t\t// insert at new index\n\t\tself.legendOrder.splice(newIndex, 0, d.seriesId)\n\t\tself.app.dispatch({\n\t\t\ttype: 'app_refresh'\n\t\t})\n\t\tself.app.tip.hide()\n\t}\n\n\tself.adjustColor = (value, d) => {\n\t\tconst color = rgb(value).formatHex()\n\t\tconst t2 = self.state.config.term2\n\t\tif (!t2) {\n\t\t\tself.app.dispatch({\n\t\t\t\ttype: 'plot_edit',\n\t\t\t\tid: self.id,\n\t\t\t\tconfig: { settings: { survival: { defaultColor: color } } }\n\t\t\t})\n\t\t} else {\n\t\t\t// this is the overlay termwrapper\n\t\t\tconst term2 = structuredClone(t2)\n\t\t\t// do not replace term2.term.values directly, will set term2.values to use as overrides\n\t\t\tif (!term2.values) term2.values = {}\n\t\t\tconst values = term2.values\n\t\t\tif (!values[d.seriesId]) values[d.seriesId] = {}\n\t\t\tif (!('key' in values[d.seriesId])) values[d.seriesId].key = d.seriesId\n\t\t\tvalues[d.seriesId].color = color\n\t\t\tself.app.dispatch({\n\t\t\t\ttype: 'plot_edit',\n\t\t\t\tid: self.id,\n\t\t\t\tconfig: {\n\t\t\t\t\tterm2\n\t\t\t\t}\n\t\t\t})\n\t\t}\n\n\t\tself.app.tip.hide()\n\t}\n\n\t// disabled as a click handler for now, need to review\n\t// before completely removing this code\n\tself.showMenuForSelectedChart = function () {\n\t\tself.dom.tip.clear()\n\t\tself.activeMenu = true\n\t\tself.dom.tip\n\t\t\t.showunder(this)\n\t\t\t.d.append('button')\n\t\t\t.html('Download SVG')\n\t\t\t.on('click', () => {\n\t\t\t\tif (!self.state) return\n\t\t\t\tconst chartDiv = select(this.closest('.pp-survival-chart'))\n\t\t\t\tdownloadChart(\n\t\t\t\t\tchartDiv.select('.sjpp-survival-mainG'),\n\t\t\t\t\t'Survival_Plot',\n\t\t\t\t\tchartDiv.node() // use to get computed styles\n\t\t\t\t)\n\t\t\t})\n\t}\n}\n\nexport async function getPlotConfig(opts, app) {\n\tif (!opts.term) throw 'survival getPlotConfig: opts.term{} missing'\n\ttry {\n\t\tawait fillTermWrapper(opts.term, app.vocabApi)\n\t\t// supply t0_t2_defaultQ if opts.term0/2.bins/q is undefined\n\t\t// so that t0_t2_defaultQ does not override bins or q from user\n\t\tif (opts.term2)\n\t\t\tawait fillTermWrapper(opts.term2, app.vocabApi, opts.term2.bins || opts.term2.q ? undefined : t0_t2_defaultQ)\n\t\tif (opts.term0)\n\t\t\tawait fillTermWrapper(opts.term0, app.vocabApi, opts.term0.bins || opts.term0.q ? undefined : t0_t2_defaultQ)\n\t} catch (e) {\n\t\tthrow `${e} [survival getPlotConfig()]`\n\t}\n\n\tconst config = {\n\t\tid: opts.term.term.id,\n\t\tcontrolLabels: Object.assign({}, defaultUiLabels, app.vocabApi.termdbConfig.uiLabels || {}),\n\t\tsettings: {\n\t\t\tcontrols: {\n\t\t\t\tterm2: null, // the previous overlay value may be displayed as a convenience for toggling\n\t\t\t\tterm0: null\n\t\t\t},\n\t\t\tsurvival: {\n\t\t\t\tradius: 5,\n\t\t\t\tciVisible: true,\n\t\t\t\tfill: '#fff',\n\t\t\t\tstroke: '#000',\n\t\t\t\tsymbol: 'vtick', // 'x', 'vtick'\n\t\t\t\tfillOpacity: 0,\n\t\t\t\tchartMargin: 10,\n\t\t\t\tsvgw: 400,\n\t\t\t\tsvgh: 300,\n\t\t\t\tnumUnitInOneYear: 1,\n\t\t\t\ttimeUnit: 'years',\n\t\t\t\tatRiskVisible: true,\n\t\t\t\tatRiskLabelOffset: -20,\n\t\t\t\txTickValues: [], // if undefined or empty, will be ignored\n\t\t\t\tseriesTipDecimals: 1,\n\t\t\t\tsvgPadding: {\n\t\t\t\t\ttop: 20,\n\t\t\t\t\tleft: 55,\n\t\t\t\t\tright: 20,\n\t\t\t\t\tbottom: 50\n\t\t\t\t},\n\t\t\t\taxisTitleFontSize: 16,\n\t\t\t\txAxisOffset: 5,\n\t\t\t\tyAxisOffset: -5,\n\t\t\t\thiddenPvalues: [],\n\t\t\t\tdefaultColor: '#2077b4'\n\t\t\t}\n\t\t}\n\t}\n\n\t// default survival settings will be overwritten by the survival settings defined in dataset\n\tconst overrides = app.vocabApi.termdbConfig.survival || {}\n\tcopyMerge(config.settings.survival, overrides.settings)\n\n\t// may apply term-specific changes to the default object\n\treturn copyMerge(config, opts)\n}\n\nfunction getPj(self) {\n\tconst pj = new Partjson({\n\t\ttemplate: {\n\t\t\tyMin: '>=yMin()',\n\t\t\tyMax: '<=yMax()',\n\t\t\tcharts: [\n\t\t\t\t{\n\t\t\t\t\tchartId: '@key',\n\t\t\t\t\trawChartId: '$chartId',\n\t\t\t\t\txMin: '>$time',\n\t\t\t\t\txMax: '<$time',\n\t\t\t\t\t'__:xScale': '=xScale()',\n\t\t\t\t\t'__:yScale': '=yScale()',\n\t\t\t\t\tyMin: '>=yMin()',\n\t\t\t\t\tyMax: '<=yMax()',\n\t\t\t\t\tserieses: [\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\tchartId: '@parent.@parent.@key',\n\t\t\t\t\t\t\tseriesId: '@key',\n\t\t\t\t\t\t\t'__:seriesLabel': '=seriesLabel()',\n\t\t\t\t\t\t\tdata: [\n\t\t\t\t\t\t\t\t{\n\t\t\t\t\t\t\t\t\t'__:seriesId': '@parent.@parent.seriesId',\n\t\t\t\t\t\t\t\t\t//color: \"$color\",\n\t\t\t\t\t\t\t\t\tx: '$time',\n\t\t\t\t\t\t\t\t\ty: '$survival',\n\t\t\t\t\t\t\t\t\tlower: '$lower',\n\t\t\t\t\t\t\t\t\tupper: '$upper',\n\t\t\t\t\t\t\t\t\t'_1:scaledX': '=scaledX()',\n\t\t\t\t\t\t\t\t\t'_1:scaledY': '=scaledY()',\n\t\t\t\t\t\t\t\t\tnevent: '$nevent',\n\t\t\t\t\t\t\t\t\tncensor: '$ncensor',\n\t\t\t\t\t\t\t\t\tnrisk: '$nrisk'\n\t\t\t\t\t\t\t\t},\n\t\t\t\t\t\t\t\t'=timeCensored()'\n\t\t\t\t\t\t\t]\n\t\t\t\t\t\t},\n\t\t\t\t\t\t'$seriesId'\n\t\t\t\t\t],\n\t\t\t\t\t'@done()': '=sortSerieses()'\n\t\t\t\t},\n\t\t\t\t'=chartTitle()'\n\t\t\t],\n\t\t\t'@done()': '=sortCharts()'\n\t\t},\n\t\t'=': {\n\t\t\tchartTitle(row) {\n\t\t\t\tif (!row.chartId || row.chartId == '-') {\n\t\t\t\t\tconst termNum = self.state.config.term.term.type == 'survival' ? 'term' : 'term2'\n\t\t\t\t\treturn self.state.config[termNum].term.name\n\t\t\t\t}\n\t\t\t\tconst t0 = self.state.config.term0\n\t\t\t\tif (!t0 || !t0.term.values) return row.chartId\n\t\t\t\tif (t0.q?.type == 'predefined-groupset' || t0.q?.type == 'custom-groupset') return row.chartId\n\t\t\t\tconst value = self.state.config.term0.term.values[row.chartId]\n\t\t\t\treturn value && value.label ? value.label : row.chartId\n\t\t\t},\n\t\t\tseriesLabel(row, context) {\n\t\t\t\tconst t2 = self.state.config.term2\n\t\t\t\tif (!t2) return\n\t\t\t\tconst seriesId = context.self.seriesId\n\t\t\t\tif (t2?.q?.type == 'predefined-groupset' || t2?.q?.type == 'custom-groupset') return seriesId\n\t\t\t\tif (t2 && t2.term.values && seriesId in t2.term.values) return t2.term.values[seriesId].label\n\t\t\t\tif (isNumericTerm(t2.term)) {\n\t\t\t\t\t// numeric term\n\t\t\t\t\t// seriesId on its own (e.g. \"<5\") will be vague,\n\t\t\t\t\t// so include term name in series label\n\t\t\t\t\treturn t2.term.name + ' ' + seriesId\n\t\t\t\t}\n\t\t\t\treturn seriesId\n\t\t\t},\n\t\t\ttimeCensored(row) {\n\t\t\t\treturn row.time + '-' + row.ncensor\n\t\t\t},\n\t\t\ty(row, context) {\n\t\t\t\tconst seriesId = context.context.parent.seriesId\n\t\t\t\treturn seriesId == 'CI' ? [row.lower, row.upper] : row[seriesId]\n\t\t\t},\n\t\t\tyMin(row) {\n\t\t\t\treturn row.lower\n\t\t\t},\n\t\t\tyMax(row) {\n\t\t\t\treturn row.upper\n\t\t\t},\n\t\t\txScale(_, context) {\n\t\t\t\tconst s = self.settings\n\t\t\t\treturn (\n\t\t\t\t\tscaleLinear()\n\t\t\t\t\t\t// force x to start at 0 because first data point will always\n\t\t\t\t\t\t// be at x=0 (see survival.R)\n\t\t\t\t\t\t.domain([0, Math.min(s.maxTimeToEvent || context.self.xMax, context.self.xMax)])\n\t\t\t\t\t\t.range([0, s.svgw - s.svgPadding.left - s.svgPadding.right])\n\t\t\t\t)\n\t\t\t},\n\t\t\tscaledX(_, context) {\n\t\t\t\treturn context.context.context.context.parent.xScale(context.self.x)\n\t\t\t},\n\t\t\tscaledY(_, context) {\n\t\t\t\tconst yScale = context.context.context.context.parent.yScale\n\t\t\t\tconst s = context.self\n\t\t\t\treturn [yScale(s.y), yScale(s.lower), yScale(s.upper)]\n\t\t\t},\n\t\t\tyScale() {\n\t\t\t\tconst s = self.settings\n\t\t\t\tconst domain = [1.05, 0]\n\t\t\t\treturn scaleLinear()\n\t\t\t\t\t.domain(domain)\n\t\t\t\t\t.range([0, s.svgh - s.svgPadding.top - s.svgPadding.bottom])\n\t\t\t},\n\t\t\tsortSerieses(result) {\n\t\t\t\tfor (const series of result.serieses) {\n\t\t\t\t\tseries.data.sort((a, b) => (a.x < b.x ? -1 : 1))\n\t\t\t\t}\n\t\t\t\tif (self.refs.orderedKeys) {\n\t\t\t\t\tconst s = self.refs.orderedKeys.series\n\t\t\t\t\tresult.serieses.sort((a, b) => s.indexOf(a.seriesId) - s.indexOf(b.seriesId))\n\t\t\t\t}\n\t\t\t\tif (self.refs.bins) {\n\t\t\t\t\tconst labelOrder = self.refs.bins.map(b => b.label)\n\t\t\t\t\tresult.serieses.sort((a, b) => labelOrder.indexOf(a.seriesId) - labelOrder.indexOf(b.seriesId))\n\t\t\t\t}\n\t\t\t},\n\t\t\tsortCharts(result) {\n\t\t\t\tif (!self.refs.orderedKeys) return\n\t\t\t\tconst c = self.refs.orderedKeys.chart\n\t\t\t\tresult.charts.sort(\n\t\t\t\t\t(a, b) =>\n\t\t\t\t\t\t(c.indexOf(a.chartId) == -1 ? c.indexOf(a.rawChartId) : c.indexOf(a.chartId)) -\n\t\t\t\t\t\t(c.indexOf(b.chartId) == -1 ? c.indexOf(b.rawChartId) : c.indexOf(b.chartId))\n\t\t\t\t)\n\t\t\t}\n\t\t}\n\t})\n\n\treturn pj\n}\n"],
+  "mappings": 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+  "names": ["v", "item", "chart", "s", "d", "Partjson"]
+}

package/dist/chunk-KBDY6GE3.js

@@ -0,0 +1,446 @@
+import {
+  schemeCategory20
+} from "./chunk-V2OJLJSK.js";
+import {
+  isNumericTerm
+} from "./chunk-SOED2SLH.js";
+import {
+  dtcnv,
+  dtsnvindel
+} from "./chunk-XRVBHNCW.js";
+import {
+  category10_default
+} from "./chunk-IH7ILDJS.js";
+import {
+  linear,
+  ordinal
+} from "./chunk-OAWQ6LOO.js";
+import {
+  __export
+} from "./chunk-HFNDKYVF.js";
+
+// plots/matrix/matrix.legend.js
+var matrix_legend_exports = {};
+__export(matrix_legend_exports, {
+  CNVkey2order: () => CNVkey2order,
+  getLegendData: () => getLegendData,
+  getLegendItemText: () => getLegendItemText
+});
+function getLegendData(legendGroups, refs, self) {
+  const s = this.settings.matrix;
+  const legendData = [];
+  const dvt = this.config.divideBy || {};
+  const dvtId = dvt && "id" in dvt ? dvt.id : dvt.name;
+  for (const $id in legendGroups) {
+    const legend = legendGroups[$id];
+    if ($id == "Consequences") {
+      for (const f of this.config.legendValueFilter.lst) {
+        if (f.tvs.term.type !== "geneVariant") continue;
+        if (f.legendGrpName != $id) continue;
+        if (f.tvs.legendFilterType == "geneVariant_soft" && f.filteredOutCats.length == 0) {
+          continue;
+        }
+        for (const v of f.tvs.values) {
+          for (const key of v.mclasslst) {
+            const legendk = v.origin ? v.origin + key : key;
+            legend.values[legendk] = {
+              key,
+              dt: v.dt,
+              origin: v.origin,
+              label: v.label || self.mclass[key].label,
+              fill: v.color || self.mclass[key]?.color,
+              order: CNVkey2order(key),
+              crossedOut: f.tvs.legendFilterType == "geneVariant_hard" ? true : false,
+              greyedOut: f.tvs.legendFilterType == "geneVariant_soft" ? true : false
+            };
+          }
+        }
+      }
+      const keys2 = Object.keys(legend.values);
+      if (!keys2.length) continue;
+      legendData.unshift({
+        name: "Consequences",
+        order: legend.order,
+        $id: legend.$id,
+        dt: legend.dt,
+        origin: legend.origin,
+        items: keys2.map((key, i) => {
+          const item = legend.values[key];
+          const count = item.samples?.size;
+          return {
+            termid: "Consequences",
+            key: item.key,
+            text: this.getLegendItemText(item, count, {}, s),
+            color: item.fill,
+            order: i,
+            border: "1px solid #ccc",
+            count,
+            isLegendItem: true,
+            dt: item.dt,
+            crossedOut: item.crossedOut,
+            greyedOut: item.greyedOut,
+            origin: item.origin
+          };
+        })
+      });
+      legendData[0].items.sort((a, b) => a.text < b.text ? -1 : 1);
+      continue;
+    }
+    const t = $id == dvtId ? { tw: dvt } : this.termOrder.find((t2) => t2.tw.$id == $id || t2.tw.legend?.group == $id) || {
+      tw: { term: { id: $id, name: $id, type: $id === "CNV" ? "geneVariant" : "" } }
+    };
+    for (const f of this.config.legendValueFilter.lst) {
+      const name = t.tw.legend?.group || t.tw.label || t.tw.term.name;
+      if (f.legendGrpName != $id && f.legendGrpName != name && f.tvs.term.name != name) continue;
+      if (f.tvs.term.type == "geneVariant") {
+        for (const v of f.tvs.values) {
+          if (legend.dt && !legend.dt.includes(v.dt)) legend.dt.push(v.dt);
+          if (f.tvs.legendFilterType == "geneVariant_soft" && f.filteredOutCats.length == 0) {
+            continue;
+          }
+          for (const key of v.mclasslst) {
+            const legendk = v.origin ? v.origin + key : key;
+            legend.values[legendk] = {
+              key,
+              dt: v.dt,
+              origin: v.origin,
+              label: v.label || self.mclass[key]?.label || "Gain and loss",
+              fill: v.color || self.mclass[key]?.color,
+              order: CNVkey2order(key),
+              crossedOut: f.tvs.legendFilterType == "geneVariant_hard" ? true : false,
+              greyedOut: f.tvs.legendFilterType == "geneVariant_soft" ? true : false
+            };
+          }
+        }
+      } else {
+        if (isNumericTerm(f.tvs.term)) {
+          if (t.ref?.bins) {
+            for (const v of f.tvs.ranges) {
+              const termValues = t.ref.bins;
+              legend.values[v.name] = {
+                key: v.name,
+                label: termValues?.find((vl) => vl.name == v.name)?.name || v.name,
+                fill: termValues?.find((vl) => vl.name == v.name)?.color,
+                crossedOut: true
+              };
+            }
+          }
+        } else if (f.tvs.term.type == "survival") {
+          for (const v of f.tvs.values) {
+            const termValues = t.tw.term.values;
+            legend.values[v.key] = {
+              key: v.key,
+              label: termValues?.[v.key]?.label || "Exit code: " + v.key,
+              fill: v.key == 1 ? "#ff7f0e" : "#1f77b4",
+              crossedOut: true
+            };
+          }
+        } else {
+          for (const v of f.tvs.values) {
+            const termValues = t.tw.term.values;
+            legend.values[v.key] = {
+              key: v.key,
+              label: termValues?.[v.key]?.label || v.key,
+              fill: termValues?.[v.key]?.color,
+              crossedOut: true
+            };
+          }
+        }
+      }
+    }
+    const keys = Object.keys(legend.values).sort();
+    const hasScale = Object.values(legend.values).find((v) => v.scale);
+    if (hasScale) {
+      if (legend === legendGroups?.CNV) {
+        const gain = legend.values["CNV_amp"];
+        const loss = legend.values["CNV_loss"];
+        if (gain?.scale && loss?.scale) {
+          const colors = loss.scales?.legend.range;
+          const domain = loss.scales?.legend.domain;
+          const setLegendAttr = (item) => {
+            return {
+              $id,
+              domain: item.scales.legend.domain,
+              key: item.key,
+              isLegendItem: true,
+              minLabel: domain[0],
+              //item.minLoss, // item.maxLabel,
+              maxLabel: domain.slice(-1)[0],
+              //item.maxGain, // item.maxLabel,
+              scale: item.scale,
+              termid: "CNV"
+            };
+          };
+          const numericInputs = {
+            cutoffMode: s.cnvValues.cutoffMode,
+            defaultPercentile: s.cnvValues.defaultPercentile,
+            percentile: s.cnvValues.percentile,
+            callback: async (obj) => {
+              const cValues = self.config.settings.matrix.cnvValues;
+              if (obj.cutoffMode == "fixed") {
+                if (cValues.min == null) cValues.min = domain[0];
+                if (cValues.max == null) cValues.max = domain[domain.length - 1];
+                if (obj.min != cValues.min) obj.max = Math.abs(obj.min);
+                else obj.min = -obj.max;
+              }
+              self.config.settings.matrix.cnvValues = {
+                defaultPercentile: self.config.settings.matrix.cnvValues.defaultPercentile,
+                cutoffMode: obj.cutoffMode,
+                min: obj.min,
+                max: obj.max,
+                percentile: obj.percentile
+              };
+              await self.app.dispatch({
+                type: "plot_edit",
+                id: self.opts.id,
+                config: self.config
+              });
+            }
+          };
+          legend.values.CNV_gain_loss = {
+            key: $id,
+            label: "Gain and Loss",
+            dt: dtcnv,
+            order: -1,
+            domain,
+            name: "CNV gain/loss",
+            scale: linear().domain(domain).range(colors),
+            scales: loss.scales,
+            //Prevent the colors and domain recalculating below
+            minLabel: domain[0],
+            //loss.maxLabel,
+            maxLabel: domain.slice(-1)[0],
+            labels: { left: "Loss", right: "Gain" },
+            parents: [Object.assign(setLegendAttr(loss), loss), Object.assign(setLegendAttr(gain), gain)],
+            samples: /* @__PURE__ */ new Set([...gain.samples, ...loss.samples]),
+            numericInputs
+          };
+          delete legend.values[gain.key];
+          delete legend.values[loss.key];
+          keys.splice(keys.indexOf(gain.key), 1);
+          keys.splice(keys.indexOf(loss.key), 1);
+          keys.push("CNV_gain_loss");
+        }
+      }
+      const legendGrpLabelMaxChars = s.legendGrpLabelMaxChars || 26;
+      legendData.push({
+        name: $id.length < legendGrpLabelMaxChars ? $id : $id.slice(0, legendGrpLabelMaxChars) + "...",
+        //name:$id,
+        order: legend.order,
+        $id: legend.$id,
+        dt: legend.dt,
+        origin: legend.origin,
+        hasScale,
+        items: keys.map((key, i) => {
+          const item = legend.values[key];
+          const count = item.samples?.size;
+          if (item.scale) {
+            const colors = item.scales?.legend?.range || getColors(item);
+            const domain = item.scales?.legend?.domain || setColorScaleDomain(item.minLabel, item.maxLabel, item.domain, colors);
+            const opts = {
+              termid: $id,
+              key: item.key,
+              text: this.getLegendItemText(item, count, t, s),
+              width: 100,
+              scale: item.scale,
+              colors,
+              domain,
+              order: "order" in item ? item.order : i,
+              count,
+              isLegendItem: true,
+              dt: item.dt,
+              crossedOut: item.crossedOut,
+              greyedOut: item.greyedOut,
+              origin: item.origin,
+              parents: item.parents,
+              labels: item.labels
+            };
+            if (item.numericInputs) {
+              opts.numericInputs = item.numericInputs;
+            }
+            return opts;
+          } else {
+            return {
+              termid: $id,
+              key: item.key,
+              text: this.getLegendItemText(item, count, t, s),
+              color: item.fill || this.colorScaleByTermId[$id](key),
+              order: "order" in item ? item.order : i,
+              count,
+              isLegendItem: true,
+              dt: item.dt,
+              crossedOut: item.crossedOut,
+              greyedOut: item.greyedOut,
+              origin: item.origin
+            };
+          }
+        })
+      });
+    } else {
+      const grp = $id;
+      const term = t.tw.term;
+      const ref = legend.ref;
+      if (ref.bins)
+        keys.sort((a, b) => ref.bins.findIndex((bin) => bin.name === a) - ref.bins.findIndex((bin) => bin.name === b));
+      else if (ref.keyOrder) keys.sort((a, b) => ref.keyOrder.indexOf(a) - ref.keyOrder.indexOf(b));
+      if (!this.colorScaleByTermId[grp])
+        this.colorScaleByTermId[grp] = keys.length < 11 ? ordinal(category10_default) : ordinal(schemeCategory20);
+      const name = t.tw.legend?.group || t.tw.label || term.name;
+      const legendGrpLabelMaxChars = s.legendGrpLabelMaxChars || 26;
+      legendData.push({
+        name: name.length < legendGrpLabelMaxChars ? name : name.slice(0, legendGrpLabelMaxChars) + "...",
+        order: legend.order,
+        $id: legend.$id,
+        dt: legend.dt,
+        origin: legend.origin,
+        items: keys.map((key, i) => {
+          const item = legend.values[key];
+          const count = item.samples?.size;
+          return {
+            $id,
+            termid: term.id || term.name,
+            key: item.key,
+            text: this.getLegendItemText(item, count, t, s),
+            color: t.scale || item.fill || this.colorScaleByTermId[grp](key),
+            order: "order" in item ? item.order : i,
+            count,
+            isExcluded: item.isExcluded,
+            //onClickCallback: this.handleLegendItemClick,
+            isLegendItem: true,
+            dt: item.dt,
+            crossedOut: item.crossedOut,
+            greyedOut: item.greyedOut,
+            origin: item.origin
+          };
+        })
+      });
+    }
+  }
+  for (const grpFilter of self.config.legendGrpFilter.lst) {
+    if (grpFilter.dt.length == 1 && grpFilter.dt[0] == 4 && !legendData.filter((l) => l.dt)?.find((l) => l.dt.length == 1 && l.dt[0] == 4)) {
+      legendData.push({
+        name: "CNV",
+        dt: grpFilter.dt,
+        origin: grpFilter.origin,
+        crossedOut: true,
+        items: grpFilter.filteredOutCats.map((fc) => {
+          return {
+            dt: 4,
+            termid: "CNV",
+            origin: grpFilter.origin,
+            key: fc,
+            text: self.mclass[fc].label,
+            color: self.mclass[fc]?.color,
+            isLegendItem: true
+          };
+        })
+      });
+    } else if (grpFilter.dt.includes(dtsnvindel)) {
+      const controlLabels = self.settings.matrix.controlLabels;
+      const groupName = grpFilter.origin ? `${grpFilter.origin[0].toUpperCase() + grpFilter.origin.slice(1)} ${controlLabels.Mutations}` : controlLabels.Mutations;
+      if (!legendData.filter((l) => l.dt)?.find((l) => l.dt.includes(dtsnvindel) && l.origin == grpFilter.origin)) {
+        legendData.push({
+          name: groupName,
+          dt: grpFilter.dt,
+          origin: grpFilter.origin,
+          crossedOut: true,
+          items: grpFilter.filteredOutCats.map((fc) => {
+            return {
+              dt: self.mclass[fc].dt,
+              origin: grpFilter.origin,
+              termid: groupName,
+              key: fc,
+              text: self.mclass[fc].label,
+              color: self.mclass[fc]?.color,
+              isLegendItem: true
+            };
+          })
+        });
+      }
+    } else if (grpFilter.dt.length == 1 && grpFilter.dt[0] == 2 && !legendData.filter((l) => l.dt)?.find((l) => l.dt.length == 1 && l.dt[0] == 2)) {
+      legendData.push({
+        name: "Fusion RNA",
+        dt: grpFilter.dt,
+        origin: grpFilter.origin,
+        crossedOut: true,
+        items: grpFilter.filteredOutCats.map((fc) => {
+          return {
+            dt: 2,
+            origin: grpFilter.origin,
+            termid: "Fusion RNA",
+            key: fc,
+            text: self.mclass[fc].label,
+            color: self.mclass[fc]?.color,
+            isLegendItem: true
+          };
+        })
+      });
+    } else if (grpFilter.dt.length == 1 && grpFilter.dt[0] == 5 && !legendData.filter((l) => l.dt)?.find((l) => l.dt.length == 1 && l.dt[0] == 5)) {
+      legendData.push({
+        name: "Structural Variation",
+        dt: grpFilter.dt,
+        origin: grpFilter.origin,
+        crossedOut: true,
+        items: grpFilter.filteredOutCats.map((fc) => {
+          return {
+            dt: 5,
+            origin: grpFilter.origin,
+            termid: "Structural Variation",
+            key: fc,
+            text: self.mclass[fc].label,
+            color: self.mclass[fc]?.color,
+            isLegendItem: true
+          };
+        })
+      });
+    }
+  }
+  for (const itemsGrp of legendData) {
+    itemsGrp.items.sort((a, b) => {
+      const getStatusOrder = (item) => {
+        if (!item.greyedOut && !item.crossedOut) return 0;
+        if (item.greyedOut && !item.crossedOut) return 1;
+        if (item.crossedOut) return 2;
+        return 3;
+      };
+      return getStatusOrder(a) - getStatusOrder(b);
+    });
+  }
+  return legendData.sort(
+    (a, b) => a.crossedOut && b.crossedOut ? 0 : a.crossedOut ? 1 : b.crossedOut ? -1 : a.order && b.order ? a.order - b.order : a.order ? -1 : b.order ? 1 : 0
+  );
+}
+function getLegendItemText(item, count, t, s) {
+  if (item.crossedOut || item.greyedOut) {
+    return item.label;
+  }
+  let text = item.label;
+  const notes = [count];
+  if (item.isExcluded) notes.push("hidden");
+  if (t?.tw?.term?.type == "geneVariant" && s.geneVariantCountSamplesSkipMclass.includes(item.key))
+    notes.push("not counted");
+  if (!notes.length) return text;
+  return text += ` (${notes.join(", ")})`;
+}
+function setColorScaleDomain(min, max, domain, colors) {
+  if (domain[0] === min && domain[domain.length - 1] === max) return domain;
+  const step = (max - min) / (colors.length - 1);
+  return colors.map((_, i) => {
+    if (i === (colors.length - 1) / 2 && min < 0 && max > 0) return 0;
+    return min + step * i;
+  });
+}
+function getColors(item) {
+  return item.domain?.map((c) => item.scale(c)) || item.scale.range();
+}
+function CNVkey2order(key) {
+  return key == "CNV_homozygous_deletion" ? -5 : key == "CNV_amplification" ? -4 : key == "CNV_loss" ? -3 : key == "CNV_amp" ? -2 : key == "CNV_loh" ? -1 : 0;
+}
+
+export {
+  getLegendData,
+  getLegendItemText,
+  CNVkey2order,
+  matrix_legend_exports
+};
+//# sourceMappingURL=chunk-KBDY6GE3.js.map