@medplum/fhirtypes 0.3.0

package/dist/MedicationKnowledge.d.ts

@@ -0,0 +1,1136 @@
+/*
+ * Generated by @medplum/generator
+ * Do not edit manually.
+ */
+
+import { CodeableConcept } from './CodeableConcept';
+import { DetectedIssue } from './DetectedIssue';
+import { DocumentReference } from './DocumentReference';
+import { Dosage } from './Dosage';
+import { Duration } from './Duration';
+import { Extension } from './Extension';
+import { Media } from './Media';
+import { Medication } from './Medication';
+import { Meta } from './Meta';
+import { Money } from './Money';
+import { Narrative } from './Narrative';
+import { ObservationDefinition } from './ObservationDefinition';
+import { Organization } from './Organization';
+import { Quantity } from './Quantity';
+import { Ratio } from './Ratio';
+import { Reference } from './Reference';
+import { Resource } from './Resource';
+import { Substance } from './Substance';
+
+/**
+ * Information about a medication that is used to support knowledge.
+ */
+export interface MedicationKnowledge {
+
+  /**
+   * This is a MedicationKnowledge resource
+   */
+  readonly resourceType: 'MedicationKnowledge';
+
+  /**
+   * The logical id of the resource, as used in the URL for the resource.
+   * Once assigned, this value never changes.
+   */
+  readonly id?: string;
+
+  /**
+   * The metadata about the resource. This is content that is maintained by
+   * the infrastructure. Changes to the content might not always be
+   * associated with version changes to the resource.
+   */
+  readonly meta?: Meta;
+
+  /**
+   * A reference to a set of rules that were followed when the resource was
+   * constructed, and which must be understood when processing the content.
+   * Often, this is a reference to an implementation guide that defines the
+   * special rules along with other profiles etc.
+   */
+  readonly implicitRules?: string;
+
+  /**
+   * The base language in which the resource is written.
+   */
+  readonly language?: string;
+
+  /**
+   * A human-readable narrative that contains a summary of the resource and
+   * can be used to represent the content of the resource to a human. The
+   * narrative need not encode all the structured data, but is required to
+   * contain sufficient detail to make it "clinically safe" for a human to
+   * just read the narrative. Resource definitions may define what content
+   * should be represented in the narrative to ensure clinical safety.
+   */
+  readonly text?: Narrative;
+
+  /**
+   * These resources do not have an independent existence apart from the
+   * resource that contains them - they cannot be identified independently,
+   * and nor can they have their own independent transaction scope.
+   */
+  readonly contained?: Resource[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the resource. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the resource and that modifies the
+   * understanding of the element that contains it and/or the understanding
+   * of the containing element's descendants. Usually modifier elements
+   * provide negation or qualification. To make the use of extensions safe
+   * and manageable, there is a strict set of governance applied to the
+   * definition and use of extensions. Though any implementer is allowed to
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension. Applications processing a
+   * resource are required to check for modifier extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * A code that specifies this medication, or a textual description if no
+   * code is available. Usage note: This could be a standard medication
+   * code such as a code from RxNorm, SNOMED CT, IDMP etc. It could also be
+   * a national or local formulary code, optionally with translations to
+   * other code systems.
+   */
+  readonly code?: CodeableConcept;
+
+  /**
+   * A code to indicate if the medication is in active use.  The status
+   * refers to the validity about the information of the medication and not
+   * to its medicinal properties.
+   */
+  readonly status?: string;
+
+  /**
+   * Describes the details of the manufacturer of the medication product.
+   * This is not intended to represent the distributor of a medication
+   * product.
+   */
+  readonly manufacturer?: Reference<Organization>;
+
+  /**
+   * Describes the form of the item.  Powder; tablets; capsule.
+   */
+  readonly doseForm?: CodeableConcept;
+
+  /**
+   * Specific amount of the drug in the packaged product.  For example,
+   * when specifying a product that has the same strength (For example,
+   * Insulin glargine 100 unit per mL solution for injection), this
+   * attribute provides additional clarification of the package amount (For
+   * example, 3 mL, 10mL, etc.).
+   */
+  readonly amount?: Quantity;
+
+  /**
+   * Additional names for a medication, for example, the name(s) given to a
+   * medication in different countries.  For example, acetaminophen and
+   * paracetamol or salbutamol and albuterol.
+   */
+  readonly synonym?: string[];
+
+  /**
+   * Associated or related knowledge about a medication.
+   */
+  readonly relatedMedicationKnowledge?: MedicationKnowledgeRelatedMedicationKnowledge[];
+
+  /**
+   * Associated or related medications.  For example, if the medication is
+   * a branded product (e.g. Crestor), this is the Therapeutic Moeity (e.g.
+   * Rosuvastatin) or if this is a generic medication (e.g. Rosuvastatin),
+   * this would link to a branded product (e.g. Crestor).
+   */
+  readonly associatedMedication?: Reference<Medication>[];
+
+  /**
+   * Category of the medication or product (e.g. branded product,
+   * therapeutic moeity, generic product, innovator product, etc.).
+   */
+  readonly productType?: CodeableConcept[];
+
+  /**
+   * Associated documentation about the medication.
+   */
+  readonly monograph?: MedicationKnowledgeMonograph[];
+
+  /**
+   * Identifies a particular constituent of interest in the product.
+   */
+  readonly ingredient?: MedicationKnowledgeIngredient[];
+
+  /**
+   * The instructions for preparing the medication.
+   */
+  readonly preparationInstruction?: string;
+
+  /**
+   * The intended or approved route of administration.
+   */
+  readonly intendedRoute?: CodeableConcept[];
+
+  /**
+   * The price of the medication.
+   */
+  readonly cost?: MedicationKnowledgeCost[];
+
+  /**
+   * The program under which the medication is reviewed.
+   */
+  readonly monitoringProgram?: MedicationKnowledgeMonitoringProgram[];
+
+  /**
+   * Guidelines for the administration of the medication.
+   */
+  readonly administrationGuidelines?: MedicationKnowledgeAdministrationGuidelines[];
+
+  /**
+   * Categorization of the medication within a formulary or classification
+   * system.
+   */
+  readonly medicineClassification?: MedicationKnowledgeMedicineClassification[];
+
+  /**
+   * Information that only applies to packages (not products).
+   */
+  readonly packaging?: MedicationKnowledgePackaging;
+
+  /**
+   * Specifies descriptive properties of the medicine, such as color,
+   * shape, imprints, etc.
+   */
+  readonly drugCharacteristic?: MedicationKnowledgeDrugCharacteristic[];
+
+  /**
+   * Potential clinical issue with or between medication(s) (for example,
+   * drug-drug interaction, drug-disease contraindication, drug-allergy
+   * interaction, etc.).
+   */
+  readonly contraindication?: Reference<DetectedIssue>[];
+
+  /**
+   * Regulatory information about a medication.
+   */
+  readonly regulatory?: MedicationKnowledgeRegulatory[];
+
+  /**
+   * The time course of drug absorption, distribution, metabolism and
+   * excretion of a medication from the body.
+   */
+  readonly kinetics?: MedicationKnowledgeKinetics[];
+}
+
+/**
+ * Guidelines for the administration of the medication.
+ */
+export interface MedicationKnowledgeAdministrationGuidelines {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * Dosage for the medication for the specific guidelines.
+   */
+  readonly dosage?: MedicationKnowledgeAdministrationGuidelinesDosage[];
+
+  /**
+   * Indication for use that apply to the specific administration
+   * guidelines.
+   */
+  readonly indicationCodeableConcept?: CodeableConcept;
+
+  /**
+   * Indication for use that apply to the specific administration
+   * guidelines.
+   */
+  readonly indicationReference?: Reference<ObservationDefinition>;
+
+  /**
+   * Characteristics of the patient that are relevant to the administration
+   * guidelines (for example, height, weight, gender, etc.).
+   */
+  readonly patientCharacteristics?: MedicationKnowledgeAdministrationGuidelinesPatientCharacteristics[];
+}
+
+/**
+ * Dosage for the medication for the specific guidelines.
+ */
+export interface MedicationKnowledgeAdministrationGuidelinesDosage {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * The type of dosage (for example, prophylaxis, maintenance,
+   * therapeutic, etc.).
+   */
+  readonly type?: CodeableConcept;
+
+  /**
+   * Dosage for the medication for the specific guidelines.
+   */
+  readonly dosage?: Dosage[];
+}
+
+/**
+ * Characteristics of the patient that are relevant to the administration
+ * guidelines (for example, height, weight, gender, etc.).
+ */
+export interface MedicationKnowledgeAdministrationGuidelinesPatientCharacteristics {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * Specific characteristic that is relevant to the administration
+   * guideline (e.g. height, weight, gender).
+   */
+  readonly characteristicCodeableConcept?: CodeableConcept;
+
+  /**
+   * Specific characteristic that is relevant to the administration
+   * guideline (e.g. height, weight, gender).
+   */
+  readonly characteristicQuantity?: Quantity;
+
+  /**
+   * The specific characteristic (e.g. height, weight, gender, etc.).
+   */
+  readonly value?: string[];
+}
+
+/**
+ * The price of the medication.
+ */
+export interface MedicationKnowledgeCost {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * The category of the cost information.  For example, manufacturers'
+   * cost, patient cost, claim reimbursement cost, actual acquisition cost.
+   */
+  readonly type?: CodeableConcept;
+
+  /**
+   * The source or owner that assigns the price to the medication.
+   */
+  readonly source?: string;
+
+  /**
+   * The price of the medication.
+   */
+  readonly cost?: Money;
+}
+
+/**
+ * Specifies descriptive properties of the medicine, such as color,
+ * shape, imprints, etc.
+ */
+export interface MedicationKnowledgeDrugCharacteristic {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * A code specifying which characteristic of the medicine is being
+   * described (for example, colour, shape, imprint).
+   */
+  readonly type?: CodeableConcept;
+
+  /**
+   * Description of the characteristic.
+   */
+  readonly valueCodeableConcept?: CodeableConcept;
+
+  /**
+   * Description of the characteristic.
+   */
+  readonly valueString?: string;
+
+  /**
+   * Description of the characteristic.
+   */
+  readonly valueQuantity?: Quantity;
+
+  /**
+   * Description of the characteristic.
+   */
+  readonly valueBase64Binary?: string;
+}
+
+/**
+ * Identifies a particular constituent of interest in the product.
+ */
+export interface MedicationKnowledgeIngredient {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * The actual ingredient - either a substance (simple ingredient) or
+   * another medication.
+   */
+  readonly itemCodeableConcept?: CodeableConcept;
+
+  /**
+   * The actual ingredient - either a substance (simple ingredient) or
+   * another medication.
+   */
+  readonly itemReference?: Reference<Substance>;
+
+  /**
+   * Indication of whether this ingredient affects the therapeutic action
+   * of the drug.
+   */
+  readonly isActive?: boolean;
+
+  /**
+   * Specifies how many (or how much) of the items there are in this
+   * Medication.  For example, 250 mg per tablet.  This is expressed as a
+   * ratio where the numerator is 250mg and the denominator is 1 tablet.
+   */
+  readonly strength?: Ratio;
+}
+
+/**
+ * The time course of drug absorption, distribution, metabolism and
+ * excretion of a medication from the body.
+ */
+export interface MedicationKnowledgeKinetics {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * The drug concentration measured at certain discrete points in time.
+   */
+  readonly areaUnderCurve?: Quantity[];
+
+  /**
+   * The median lethal dose of a drug.
+   */
+  readonly lethalDose50?: Quantity[];
+
+  /**
+   * The time required for any specified property (e.g., the concentration
+   * of a substance in the body) to decrease by half.
+   */
+  readonly halfLifePeriod?: Duration;
+}
+
+/**
+ * Categorization of the medication within a formulary or classification
+ * system.
+ */
+export interface MedicationKnowledgeMedicineClassification {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * The type of category for the medication (for example, therapeutic
+   * classification, therapeutic sub-classification).
+   */
+  readonly type?: CodeableConcept;
+
+  /**
+   * Specific category assigned to the medication (e.g. anti-infective,
+   * anti-hypertensive, antibiotic, etc.).
+   */
+  readonly classification?: CodeableConcept[];
+}
+
+/**
+ * The program under which the medication is reviewed.
+ */
+export interface MedicationKnowledgeMonitoringProgram {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * Type of program under which the medication is monitored.
+   */
+  readonly type?: CodeableConcept;
+
+  /**
+   * Name of the reviewing program.
+   */
+  readonly name?: string;
+}
+
+/**
+ * Associated documentation about the medication.
+ */
+export interface MedicationKnowledgeMonograph {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * The category of documentation about the medication. (e.g. professional
+   * monograph, patient education monograph).
+   */
+  readonly type?: CodeableConcept;
+
+  /**
+   * Associated documentation about the medication.
+   */
+  readonly source?: Reference<DocumentReference | Media>;
+}
+
+/**
+ * Information that only applies to packages (not products).
+ */
+export interface MedicationKnowledgePackaging {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * A code that defines the specific type of packaging that the medication
+   * can be found in (e.g. blister sleeve, tube, bottle).
+   */
+  readonly type?: CodeableConcept;
+
+  /**
+   * The number of product units the package would contain if fully loaded.
+   */
+  readonly quantity?: Quantity;
+}
+
+/**
+ * Regulatory information about a medication.
+ */
+export interface MedicationKnowledgeRegulatory {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * The authority that is specifying the regulations.
+   */
+  readonly regulatoryAuthority?: Reference<Organization>;
+
+  /**
+   * Specifies if changes are allowed when dispensing a medication from a
+   * regulatory perspective.
+   */
+  readonly substitution?: MedicationKnowledgeRegulatorySubstitution[];
+
+  /**
+   * Specifies the schedule of a medication in jurisdiction.
+   */
+  readonly schedule?: MedicationKnowledgeRegulatorySchedule[];
+
+  /**
+   * The maximum number of units of the medication that can be dispensed in
+   * a period.
+   */
+  readonly maxDispense?: MedicationKnowledgeRegulatoryMaxDispense;
+}
+
+/**
+ * The maximum number of units of the medication that can be dispensed in
+ * a period.
+ */
+export interface MedicationKnowledgeRegulatoryMaxDispense {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * The maximum number of units of the medication that can be dispensed.
+   */
+  readonly quantity?: Quantity;
+
+  /**
+   * The period that applies to the maximum number of units.
+   */
+  readonly period?: Duration;
+}
+
+/**
+ * Specifies the schedule of a medication in jurisdiction.
+ */
+export interface MedicationKnowledgeRegulatorySchedule {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * Specifies the specific drug schedule.
+   */
+  readonly schedule?: CodeableConcept;
+}
+
+/**
+ * Specifies if changes are allowed when dispensing a medication from a
+ * regulatory perspective.
+ */
+export interface MedicationKnowledgeRegulatorySubstitution {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * Specifies the type of substitution allowed.
+   */
+  readonly type?: CodeableConcept;
+
+  /**
+   * Specifies if regulation allows for changes in the medication when
+   * dispensing.
+   */
+  readonly allowed?: boolean;
+}
+
+/**
+ * Associated or related knowledge about a medication.
+ */
+export interface MedicationKnowledgeRelatedMedicationKnowledge {
+
+  /**
+   * Unique id for the element within a resource (for internal references).
+   * This may be any string value that does not contain spaces.
+   */
+  readonly id?: string;
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element. To make the use of extensions
+   * safe and manageable, there is a strict set of governance  applied to
+   * the definition and use of extensions. Though any implementer can
+   * define an extension, there is a set of requirements that SHALL be met
+   * as part of the definition of the extension.
+   */
+  readonly extension?: Extension[];
+
+  /**
+   * May be used to represent additional information that is not part of
+   * the basic definition of the element and that modifies the
+   * understanding of the element in which it is contained and/or the
+   * understanding of the containing element's descendants. Usually
+   * modifier elements provide negation or qualification. To make the use
+   * of extensions safe and manageable, there is a strict set of governance
+   * applied to the definition and use of extensions. Though any
+   * implementer can define an extension, there is a set of requirements
+   * that SHALL be met as part of the definition of the extension.
+   * Applications processing a resource are required to check for modifier
+   * extensions.
+   *
+   * Modifier extensions SHALL NOT change the meaning of any elements on
+   * Resource or DomainResource (including cannot change the meaning of
+   * modifierExtension itself).
+   */
+  readonly modifierExtension?: Extension[];
+
+  /**
+   * The category of the associated medication knowledge reference.
+   */
+  readonly type?: CodeableConcept;
+
+  /**
+   * Associated documentation about the associated medication knowledge.
+   */
+  readonly reference?: Reference<MedicationKnowledge>[];
+}