@jbrowse/plugin-variants 1.7.0 → 1.7.4

package/dist/plugin-variants.cjs.development.js

@@ -1,2897 +0,0 @@
-'use strict';
-
-Object.defineProperty(exports, '__esModule', { value: true });
-
-function _interopDefault (ex) { return (ex && (typeof ex === 'object') && 'default' in ex) ? ex['default'] : ex; }
-
-var React = require('react');
-var React__default = _interopDefault(React);
-var configuration = require('@jbrowse/core/configuration');
-var AdapterType = _interopDefault(require('@jbrowse/core/pluggableElementTypes/AdapterType'));
-var DisplayType = _interopDefault(require('@jbrowse/core/pluggableElementTypes/DisplayType'));
-var models = require('@jbrowse/core/pluggableElementTypes/models');
-var TrackType = _interopDefault(require('@jbrowse/core/pluggableElementTypes/TrackType'));
-var WidgetType = _interopDefault(require('@jbrowse/core/pluggableElementTypes/WidgetType'));
-var Plugin = _interopDefault(require('@jbrowse/core/Plugin'));
-var pluginLinearGenomeView = require('@jbrowse/plugin-linear-genome-view');
-var pluginCircularView = require('@jbrowse/plugin-circular-view');
-var tracks = require('@jbrowse/core/util/tracks');
-var util = require('@jbrowse/core/util');
-var mobxStateTree = require('mobx-state-tree');
-var ChordRendererType = _interopDefault(require('@jbrowse/core/pluggableElementTypes/renderers/CircularChordRendererType'));
-var mobxReact = require('mobx-react');
-var mst = require('@jbrowse/core/util/types/mst');
-var VCF = require('@gmod/vcf');
-var VCF__default = _interopDefault(VCF);
-var PropTypes = _interopDefault(require('prop-types'));
-var BaseAdapter = require('@jbrowse/core/data_adapters/BaseAdapter');
-var io = require('@jbrowse/core/util/io');
-var rxjs = require('@jbrowse/core/util/rxjs');
-var tabix = require('@gmod/tabix');
-var IntervalTree = _interopDefault(require('@flatten-js/interval-tree'));
-var bgzfFilehandle = require('@gmod/bgzf-filehandle');
-var core = require('@material-ui/core');
-var SimpleFeature = _interopDefault(require('@jbrowse/core/util/simpleFeature'));
-var xDataGrid = require('@mui/x-data-grid');
-var BaseFeatureDetail = require('@jbrowse/core/BaseFeatureWidget/BaseFeatureDetail');
-var CloseIcon = _interopDefault(require('@material-ui/icons/Close'));
-
-function ownKeys(object, enumerableOnly) {
-  var keys = Object.keys(object);
-
-  if (Object.getOwnPropertySymbols) {
-    var symbols = Object.getOwnPropertySymbols(object);
-    enumerableOnly && (symbols = symbols.filter(function (sym) {
-      return Object.getOwnPropertyDescriptor(object, sym).enumerable;
-    })), keys.push.apply(keys, symbols);
-  }
-
-  return keys;
-}
-
-function _objectSpread2(target) {
-  for (var i = 1; i < arguments.length; i++) {
-    var source = null != arguments[i] ? arguments[i] : {};
-    i % 2 ? ownKeys(Object(source), !0).forEach(function (key) {
-      _defineProperty(target, key, source[key]);
-    }) : Object.getOwnPropertyDescriptors ? Object.defineProperties(target, Object.getOwnPropertyDescriptors(source)) : ownKeys(Object(source)).forEach(function (key) {
-      Object.defineProperty(target, key, Object.getOwnPropertyDescriptor(source, key));
-    });
-  }
-
-  return target;
-}
-
-function asyncGeneratorStep(gen, resolve, reject, _next, _throw, key, arg) {
-  try {
-    var info = gen[key](arg);
-    var value = info.value;
-  } catch (error) {
-    reject(error);
-    return;
-  }
-
-  if (info.done) {
-    resolve(value);
-  } else {
-    Promise.resolve(value).then(_next, _throw);
-  }
-}
-
-function _asyncToGenerator(fn) {
-  return function () {
-    var self = this,
-        args = arguments;
-    return new Promise(function (resolve, reject) {
-      var gen = fn.apply(self, args);
-
-      function _next(value) {
-        asyncGeneratorStep(gen, resolve, reject, _next, _throw, "next", value);
-      }
-
-      function _throw(err) {
-        asyncGeneratorStep(gen, resolve, reject, _next, _throw, "throw", err);
-      }
-
-      _next(undefined);
-    });
-  };
-}
-
-function _classCallCheck(instance, Constructor) {
-  if (!(instance instanceof Constructor)) {
-    throw new TypeError("Cannot call a class as a function");
-  }
-}
-
-function _defineProperties(target, props) {
-  for (var i = 0; i < props.length; i++) {
-    var descriptor = props[i];
-    descriptor.enumerable = descriptor.enumerable || false;
-    descriptor.configurable = true;
-    if ("value" in descriptor) descriptor.writable = true;
-    Object.defineProperty(target, descriptor.key, descriptor);
-  }
-}
-
-function _createClass(Constructor, protoProps, staticProps) {
-  if (protoProps) _defineProperties(Constructor.prototype, protoProps);
-  if (staticProps) _defineProperties(Constructor, staticProps);
-  Object.defineProperty(Constructor, "prototype", {
-    writable: false
-  });
-  return Constructor;
-}
-
-function _defineProperty(obj, key, value) {
-  if (key in obj) {
-    Object.defineProperty(obj, key, {
-      value: value,
-      enumerable: true,
-      configurable: true,
-      writable: true
-    });
-  } else {
-    obj[key] = value;
-  }
-
-  return obj;
-}
-
-function _inherits(subClass, superClass) {
-  if (typeof superClass !== "function" && superClass !== null) {
-    throw new TypeError("Super expression must either be null or a function");
-  }
-
-  subClass.prototype = Object.create(superClass && superClass.prototype, {
-    constructor: {
-      value: subClass,
-      writable: true,
-      configurable: true
-    }
-  });
-  Object.defineProperty(subClass, "prototype", {
-    writable: false
-  });
-  if (superClass) _setPrototypeOf(subClass, superClass);
-}
-
-function _getPrototypeOf(o) {
-  _getPrototypeOf = Object.setPrototypeOf ? Object.getPrototypeOf : function _getPrototypeOf(o) {
-    return o.__proto__ || Object.getPrototypeOf(o);
-  };
-  return _getPrototypeOf(o);
-}
-
-function _setPrototypeOf(o, p) {
-  _setPrototypeOf = Object.setPrototypeOf || function _setPrototypeOf(o, p) {
-    o.__proto__ = p;
-    return o;
-  };
-
-  return _setPrototypeOf(o, p);
-}
-
-function _isNativeReflectConstruct() {
-  if (typeof Reflect === "undefined" || !Reflect.construct) return false;
-  if (Reflect.construct.sham) return false;
-  if (typeof Proxy === "function") return true;
-
-  try {
-    Boolean.prototype.valueOf.call(Reflect.construct(Boolean, [], function () {}));
-    return true;
-  } catch (e) {
-    return false;
-  }
-}
-
-function _objectWithoutPropertiesLoose(source, excluded) {
-  if (source == null) return {};
-  var target = {};
-  var sourceKeys = Object.keys(source);
-  var key, i;
-
-  for (i = 0; i < sourceKeys.length; i++) {
-    key = sourceKeys[i];
-    if (excluded.indexOf(key) >= 0) continue;
-    target[key] = source[key];
-  }
-
-  return target;
-}
-
-function _objectWithoutProperties(source, excluded) {
-  if (source == null) return {};
-
-  var target = _objectWithoutPropertiesLoose(source, excluded);
-
-  var key, i;
-
-  if (Object.getOwnPropertySymbols) {
-    var sourceSymbolKeys = Object.getOwnPropertySymbols(source);
-
-    for (i = 0; i < sourceSymbolKeys.length; i++) {
-      key = sourceSymbolKeys[i];
-      if (excluded.indexOf(key) >= 0) continue;
-      if (!Object.prototype.propertyIsEnumerable.call(source, key)) continue;
-      target[key] = source[key];
-    }
-  }
-
-  return target;
-}
-
-function _assertThisInitialized(self) {
-  if (self === void 0) {
-    throw new ReferenceError("this hasn't been initialised - super() hasn't been called");
-  }
-
-  return self;
-}
-
-function _possibleConstructorReturn(self, call) {
-  if (call && (typeof call === "object" || typeof call === "function")) {
-    return call;
-  } else if (call !== void 0) {
-    throw new TypeError("Derived constructors may only return object or undefined");
-  }
-
-  return _assertThisInitialized(self);
-}
-
-function _createSuper(Derived) {
-  var hasNativeReflectConstruct = _isNativeReflectConstruct();
-
-  return function _createSuperInternal() {
-    var Super = _getPrototypeOf(Derived),
-        result;
-
-    if (hasNativeReflectConstruct) {
-      var NewTarget = _getPrototypeOf(this).constructor;
-
-      result = Reflect.construct(Super, arguments, NewTarget);
-    } else {
-      result = Super.apply(this, arguments);
-    }
-
-    return _possibleConstructorReturn(this, result);
-  };
-}
-
-function _superPropBase(object, property) {
-  while (!Object.prototype.hasOwnProperty.call(object, property)) {
-    object = _getPrototypeOf(object);
-    if (object === null) break;
-  }
-
-  return object;
-}
-
-function _get() {
-  if (typeof Reflect !== "undefined" && Reflect.get) {
-    _get = Reflect.get;
-  } else {
-    _get = function _get(target, property, receiver) {
-      var base = _superPropBase(target, property);
-
-      if (!base) return;
-      var desc = Object.getOwnPropertyDescriptor(base, property);
-
-      if (desc.get) {
-        return desc.get.call(arguments.length < 3 ? target : receiver);
-      }
-
-      return desc.value;
-    };
-  }
-
-  return _get.apply(this, arguments);
-}
-
-function _slicedToArray(arr, i) {
-  return _arrayWithHoles(arr) || _iterableToArrayLimit(arr, i) || _unsupportedIterableToArray(arr, i) || _nonIterableRest();
-}
-
-function _toConsumableArray(arr) {
-  return _arrayWithoutHoles(arr) || _iterableToArray(arr) || _unsupportedIterableToArray(arr) || _nonIterableSpread();
-}
-
-function _arrayWithoutHoles(arr) {
-  if (Array.isArray(arr)) return _arrayLikeToArray(arr);
-}
-
-function _arrayWithHoles(arr) {
-  if (Array.isArray(arr)) return arr;
-}
-
-function _iterableToArray(iter) {
-  if (typeof Symbol !== "undefined" && iter[Symbol.iterator] != null || iter["@@iterator"] != null) return Array.from(iter);
-}
-
-function _iterableToArrayLimit(arr, i) {
-  var _i = arr == null ? null : typeof Symbol !== "undefined" && arr[Symbol.iterator] || arr["@@iterator"];
-
-  if (_i == null) return;
-  var _arr = [];
-  var _n = true;
-  var _d = false;
-
-  var _s, _e;
-
-  try {
-    for (_i = _i.call(arr); !(_n = (_s = _i.next()).done); _n = true) {
-      _arr.push(_s.value);
-
-      if (i && _arr.length === i) break;
-    }
-  } catch (err) {
-    _d = true;
-    _e = err;
-  } finally {
-    try {
-      if (!_n && _i["return"] != null) _i["return"]();
-    } finally {
-      if (_d) throw _e;
-    }
-  }
-
-  return _arr;
-}
-
-function _unsupportedIterableToArray(o, minLen) {
-  if (!o) return;
-  if (typeof o === "string") return _arrayLikeToArray(o, minLen);
-  var n = Object.prototype.toString.call(o).slice(8, -1);
-  if (n === "Object" && o.constructor) n = o.constructor.name;
-  if (n === "Map" || n === "Set") return Array.from(o);
-  if (n === "Arguments" || /^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)) return _arrayLikeToArray(o, minLen);
-}
-
-function _arrayLikeToArray(arr, len) {
-  if (len == null || len > arr.length) len = arr.length;
-
-  for (var i = 0, arr2 = new Array(len); i < len; i++) arr2[i] = arr[i];
-
-  return arr2;
-}
-
-function _nonIterableSpread() {
-  throw new TypeError("Invalid attempt to spread non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.");
-}
-
-function _nonIterableRest() {
-  throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.");
-}
-
-function _createForOfIteratorHelper(o, allowArrayLike) {
-  var it = typeof Symbol !== "undefined" && o[Symbol.iterator] || o["@@iterator"];
-
-  if (!it) {
-    if (Array.isArray(o) || (it = _unsupportedIterableToArray(o)) || allowArrayLike && o && typeof o.length === "number") {
-      if (it) o = it;
-      var i = 0;
-
-      var F = function () {};
-
-      return {
-        s: F,
-        n: function () {
-          if (i >= o.length) return {
-            done: true
-          };
-          return {
-            done: false,
-            value: o[i++]
-          };
-        },
-        e: function (e) {
-          throw e;
-        },
-        f: F
-      };
-    }
-
-    throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.");
-  }
-
-  var normalCompletion = true,
-      didErr = false,
-      err;
-  return {
-    s: function () {
-      it = it.call(o);
-    },
-    n: function () {
-      var step = it.next();
-      normalCompletion = step.done;
-      return step;
-    },
-    e: function (e) {
-      didErr = true;
-      err = e;
-    },
-    f: function () {
-      try {
-        if (!normalCompletion && it.return != null) it.return();
-      } finally {
-        if (didErr) throw err;
-      }
-    }
-  };
-}
-
-var ChordVariantDisplayF = function ChordVariantDisplayF(pluginManager) {
-  var jbrequire = pluginManager.jbrequire;
-
-  var _jbrequire = jbrequire('mobx-state-tree'),
-      types = _jbrequire.types;
-
-  var _jbrequire2 = jbrequire('@jbrowse/core/configuration'),
-      ConfigurationSchema = _jbrequire2.ConfigurationSchema,
-      ConfigurationReference = _jbrequire2.ConfigurationReference;
-
-  var _jbrequire3 = jbrequire('@jbrowse/core/util'),
-      getContainingView = _jbrequire3.getContainingView;
-
-  var _jbrequire4 = jbrequire('@jbrowse/core/util/tracks'),
-      getParentRenderProps = _jbrequire4.getParentRenderProps;
-
-  var configSchema = ConfigurationSchema('ChordVariantDisplay', {
-    renderer: types.optional(pluginManager.pluggableConfigSchemaType('renderer'), {
-      type: 'StructuralVariantChordRenderer'
-    })
-  }, {
-    baseConfiguration: pluginCircularView.baseChordDisplayConfig,
-    explicitlyTyped: true
-  });
-  var stateModel = types.compose('ChordVariantDisplay', pluginCircularView.BaseChordDisplayModel, types.model({
-    type: types.literal('ChordVariantDisplay'),
-    configuration: ConfigurationReference(configSchema)
-  })).views(function (self) {
-    return {
-      get rendererTypeName() {
-        return self.configuration.renderer.type;
-      },
-
-      renderProps: function renderProps() {
-        var view = getContainingView(self);
-        return _objectSpread2(_objectSpread2({}, getParentRenderProps(self)), {}, {
-          rpcDriverName: self.rpcDriverName,
-          displayModel: self,
-          bezierRadius: view.radiusPx * self.bezierRadiusRatio,
-          radius: view.radiusPx,
-          blockDefinitions: this.blockDefinitions,
-          config: self.configuration.renderer,
-          onChordClick: self.onChordClick
-        });
-      }
-    };
-  });
-  return {
-    stateModel: stateModel,
-    configSchema: configSchema
-  };
-}; // http://localhost:3000/test_data/hs37d5.HG002-SequelII-CCS.sv.vcf.gz.tbi
-
-var ChordVariantDisplay = (function (pluginManager) {
-  var lib = pluginManager.lib,
-      load = pluginManager.load;
-  var DisplayType = lib['@jbrowse/core/pluggableElementTypes/DisplayType'];
-
-  var _load = load(ChordVariantDisplayF),
-      stateModel = _load.stateModel,
-      configSchema = _load.configSchema;
-
-  return new DisplayType({
-    name: 'ChordVariantDisplay',
-    configSchema: configSchema,
-    stateModel: stateModel,
-    trackType: 'VariantTrack',
-    viewType: 'CircularView',
-    ReactComponent: pluginCircularView.BaseChordDisplayComponentFactory(pluginManager)
-  });
-});
-
-function LinearVariantDisplayConfigFactory(pluginManager) {
-  var configSchema = pluginLinearGenomeView.linearBasicDisplayConfigSchemaFactory(pluginManager);
-  return configuration.ConfigurationSchema('LinearVariantDisplay', {}, {
-    baseConfiguration: configSchema,
-    explicitlyTyped: true
-  });
-}
-
-function createCommonjsModule(fn, module) {
-	return module = { exports: {} }, fn(module, module.exports), module.exports;
-}
-
-var runtime_1 = /*#__PURE__*/createCommonjsModule(function (module) {
-  /**
-   * Copyright (c) 2014-present, Facebook, Inc.
-   *
-   * This source code is licensed under the MIT license found in the
-   * LICENSE file in the root directory of this source tree.
-   */
-  var runtime = function (exports) {
-
-    var Op = Object.prototype;
-    var hasOwn = Op.hasOwnProperty;
-    var undefined$1; // More compressible than void 0.
-
-    var $Symbol = typeof Symbol === "function" ? Symbol : {};
-    var iteratorSymbol = $Symbol.iterator || "@@iterator";
-    var asyncIteratorSymbol = $Symbol.asyncIterator || "@@asyncIterator";
-    var toStringTagSymbol = $Symbol.toStringTag || "@@toStringTag";
-
-    function define(obj, key, value) {
-      Object.defineProperty(obj, key, {
-        value: value,
-        enumerable: true,
-        configurable: true,
-        writable: true
-      });
-      return obj[key];
-    }
-
-    try {
-      // IE 8 has a broken Object.defineProperty that only works on DOM objects.
-      define({}, "");
-    } catch (err) {
-      define = function define(obj, key, value) {
-        return obj[key] = value;
-      };
-    }
-
-    function wrap(innerFn, outerFn, self, tryLocsList) {
-      // If outerFn provided and outerFn.prototype is a Generator, then outerFn.prototype instanceof Generator.
-      var protoGenerator = outerFn && outerFn.prototype instanceof Generator ? outerFn : Generator;
-      var generator = Object.create(protoGenerator.prototype);
-      var context = new Context(tryLocsList || []); // The ._invoke method unifies the implementations of the .next,
-      // .throw, and .return methods.
-
-      generator._invoke = makeInvokeMethod(innerFn, self, context);
-      return generator;
-    }
-
-    exports.wrap = wrap; // Try/catch helper to minimize deoptimizations. Returns a completion
-    // record like context.tryEntries[i].completion. This interface could
-    // have been (and was previously) designed to take a closure to be
-    // invoked without arguments, but in all the cases we care about we
-    // already have an existing method we want to call, so there's no need
-    // to create a new function object. We can even get away with assuming
-    // the method takes exactly one argument, since that happens to be true
-    // in every case, so we don't have to touch the arguments object. The
-    // only additional allocation required is the completion record, which
-    // has a stable shape and so hopefully should be cheap to allocate.
-
-    function tryCatch(fn, obj, arg) {
-      try {
-        return {
-          type: "normal",
-          arg: fn.call(obj, arg)
-        };
-      } catch (err) {
-        return {
-          type: "throw",
-          arg: err
-        };
-      }
-    }
-
-    var GenStateSuspendedStart = "suspendedStart";
-    var GenStateSuspendedYield = "suspendedYield";
-    var GenStateExecuting = "executing";
-    var GenStateCompleted = "completed"; // Returning this object from the innerFn has the same effect as
-    // breaking out of the dispatch switch statement.
-
-    var ContinueSentinel = {}; // Dummy constructor functions that we use as the .constructor and
-    // .constructor.prototype properties for functions that return Generator
-    // objects. For full spec compliance, you may wish to configure your
-    // minifier not to mangle the names of these two functions.
-
-    function Generator() {}
-
-    function GeneratorFunction() {}
-
-    function GeneratorFunctionPrototype() {} // This is a polyfill for %IteratorPrototype% for environments that
-    // don't natively support it.
-
-
-    var IteratorPrototype = {};
-    define(IteratorPrototype, iteratorSymbol, function () {
-      return this;
-    });
-    var getProto = Object.getPrototypeOf;
-    var NativeIteratorPrototype = getProto && getProto(getProto(values([])));
-
-    if (NativeIteratorPrototype && NativeIteratorPrototype !== Op && hasOwn.call(NativeIteratorPrototype, iteratorSymbol)) {
-      // This environment has a native %IteratorPrototype%; use it instead
-      // of the polyfill.
-      IteratorPrototype = NativeIteratorPrototype;
-    }
-
-    var Gp = GeneratorFunctionPrototype.prototype = Generator.prototype = Object.create(IteratorPrototype);
-    GeneratorFunction.prototype = GeneratorFunctionPrototype;
-    define(Gp, "constructor", GeneratorFunctionPrototype);
-    define(GeneratorFunctionPrototype, "constructor", GeneratorFunction);
-    GeneratorFunction.displayName = define(GeneratorFunctionPrototype, toStringTagSymbol, "GeneratorFunction"); // Helper for defining the .next, .throw, and .return methods of the
-    // Iterator interface in terms of a single ._invoke method.
-
-    function defineIteratorMethods(prototype) {
-      ["next", "throw", "return"].forEach(function (method) {
-        define(prototype, method, function (arg) {
-          return this._invoke(method, arg);
-        });
-      });
-    }
-
-    exports.isGeneratorFunction = function (genFun) {
-      var ctor = typeof genFun === "function" && genFun.constructor;
-      return ctor ? ctor === GeneratorFunction || // For the native GeneratorFunction constructor, the best we can
-      // do is to check its .name property.
-      (ctor.displayName || ctor.name) === "GeneratorFunction" : false;
-    };
-
-    exports.mark = function (genFun) {
-      if (Object.setPrototypeOf) {
-        Object.setPrototypeOf(genFun, GeneratorFunctionPrototype);
-      } else {
-        genFun.__proto__ = GeneratorFunctionPrototype;
-        define(genFun, toStringTagSymbol, "GeneratorFunction");
-      }
-
-      genFun.prototype = Object.create(Gp);
-      return genFun;
-    }; // Within the body of any async function, `await x` is transformed to
-    // `yield regeneratorRuntime.awrap(x)`, so that the runtime can test
-    // `hasOwn.call(value, "__await")` to determine if the yielded value is
-    // meant to be awaited.
-
-
-    exports.awrap = function (arg) {
-      return {
-        __await: arg
-      };
-    };
-
-    function AsyncIterator(generator, PromiseImpl) {
-      function invoke(method, arg, resolve, reject) {
-        var record = tryCatch(generator[method], generator, arg);
-
-        if (record.type === "throw") {
-          reject(record.arg);
-        } else {
-          var result = record.arg;
-          var value = result.value;
-
-          if (value && typeof value === "object" && hasOwn.call(value, "__await")) {
-            return PromiseImpl.resolve(value.__await).then(function (value) {
-              invoke("next", value, resolve, reject);
-            }, function (err) {
-              invoke("throw", err, resolve, reject);
-            });
-          }
-
-          return PromiseImpl.resolve(value).then(function (unwrapped) {
-            // When a yielded Promise is resolved, its final value becomes
-            // the .value of the Promise<{value,done}> result for the
-            // current iteration.
-            result.value = unwrapped;
-            resolve(result);
-          }, function (error) {
-            // If a rejected Promise was yielded, throw the rejection back
-            // into the async generator function so it can be handled there.
-            return invoke("throw", error, resolve, reject);
-          });
-        }
-      }
-
-      var previousPromise;
-
-      function enqueue(method, arg) {
-        function callInvokeWithMethodAndArg() {
-          return new PromiseImpl(function (resolve, reject) {
-            invoke(method, arg, resolve, reject);
-          });
-        }
-
-        return previousPromise = // If enqueue has been called before, then we want to wait until
-        // all previous Promises have been resolved before calling invoke,
-        // so that results are always delivered in the correct order. If
-        // enqueue has not been called before, then it is important to
-        // call invoke immediately, without waiting on a callback to fire,
-        // so that the async generator function has the opportunity to do
-        // any necessary setup in a predictable way. This predictability
-        // is why the Promise constructor synchronously invokes its
-        // executor callback, and why async functions synchronously
-        // execute code before the first await. Since we implement simple
-        // async functions in terms of async generators, it is especially
-        // important to get this right, even though it requires care.
-        previousPromise ? previousPromise.then(callInvokeWithMethodAndArg, // Avoid propagating failures to Promises returned by later
-        // invocations of the iterator.
-        callInvokeWithMethodAndArg) : callInvokeWithMethodAndArg();
-      } // Define the unified helper method that is used to implement .next,
-      // .throw, and .return (see defineIteratorMethods).
-
-
-      this._invoke = enqueue;
-    }
-
-    defineIteratorMethods(AsyncIterator.prototype);
-    define(AsyncIterator.prototype, asyncIteratorSymbol, function () {
-      return this;
-    });
-    exports.AsyncIterator = AsyncIterator; // Note that simple async functions are implemented on top of
-    // AsyncIterator objects; they just return a Promise for the value of
-    // the final result produced by the iterator.
-
-    exports.async = function (innerFn, outerFn, self, tryLocsList, PromiseImpl) {
-      if (PromiseImpl === void 0) PromiseImpl = Promise;
-      var iter = new AsyncIterator(wrap(innerFn, outerFn, self, tryLocsList), PromiseImpl);
-      return exports.isGeneratorFunction(outerFn) ? iter // If outerFn is a generator, return the full iterator.
-      : iter.next().then(function (result) {
-        return result.done ? result.value : iter.next();
-      });
-    };
-
-    function makeInvokeMethod(innerFn, self, context) {
-      var state = GenStateSuspendedStart;
-      return function invoke(method, arg) {
-        if (state === GenStateExecuting) {
-          throw new Error("Generator is already running");
-        }
-
-        if (state === GenStateCompleted) {
-          if (method === "throw") {
-            throw arg;
-          } // Be forgiving, per 25.3.3.3.3 of the spec:
-          // https://people.mozilla.org/~jorendorff/es6-draft.html#sec-generatorresume
-
-
-          return doneResult();
-        }
-
-        context.method = method;
-        context.arg = arg;
-
-        while (true) {
-          var delegate = context.delegate;
-
-          if (delegate) {
-            var delegateResult = maybeInvokeDelegate(delegate, context);
-
-            if (delegateResult) {
-              if (delegateResult === ContinueSentinel) continue;
-              return delegateResult;
-            }
-          }
-
-          if (context.method === "next") {
-            // Setting context._sent for legacy support of Babel's
-            // function.sent implementation.
-            context.sent = context._sent = context.arg;
-          } else if (context.method === "throw") {
-            if (state === GenStateSuspendedStart) {
-              state = GenStateCompleted;
-              throw context.arg;
-            }
-
-            context.dispatchException(context.arg);
-          } else if (context.method === "return") {
-            context.abrupt("return", context.arg);
-          }
-
-          state = GenStateExecuting;
-          var record = tryCatch(innerFn, self, context);
-
-          if (record.type === "normal") {
-            // If an exception is thrown from innerFn, we leave state ===
-            // GenStateExecuting and loop back for another invocation.
-            state = context.done ? GenStateCompleted : GenStateSuspendedYield;
-
-            if (record.arg === ContinueSentinel) {
-              continue;
-            }
-
-            return {
-              value: record.arg,
-              done: context.done
-            };
-          } else if (record.type === "throw") {
-            state = GenStateCompleted; // Dispatch the exception by looping back around to the
-            // context.dispatchException(context.arg) call above.
-
-            context.method = "throw";
-            context.arg = record.arg;
-          }
-        }
-      };
-    } // Call delegate.iterator[context.method](context.arg) and handle the
-    // result, either by returning a { value, done } result from the
-    // delegate iterator, or by modifying context.method and context.arg,
-    // setting context.delegate to null, and returning the ContinueSentinel.
-
-
-    function maybeInvokeDelegate(delegate, context) {
-      var method = delegate.iterator[context.method];
-
-      if (method === undefined$1) {
-        // A .throw or .return when the delegate iterator has no .throw
-        // method always terminates the yield* loop.
-        context.delegate = null;
-
-        if (context.method === "throw") {
-          // Note: ["return"] must be used for ES3 parsing compatibility.
-          if (delegate.iterator["return"]) {
-            // If the delegate iterator has a return method, give it a
-            // chance to clean up.
-            context.method = "return";
-            context.arg = undefined$1;
-            maybeInvokeDelegate(delegate, context);
-
-            if (context.method === "throw") {
-              // If maybeInvokeDelegate(context) changed context.method from
-              // "return" to "throw", let that override the TypeError below.
-              return ContinueSentinel;
-            }
-          }
-
-          context.method = "throw";
-          context.arg = new TypeError("The iterator does not provide a 'throw' method");
-        }
-
-        return ContinueSentinel;
-      }
-
-      var record = tryCatch(method, delegate.iterator, context.arg);
-
-      if (record.type === "throw") {
-        context.method = "throw";
-        context.arg = record.arg;
-        context.delegate = null;
-        return ContinueSentinel;
-      }
-
-      var info = record.arg;
-
-      if (!info) {
-        context.method = "throw";
-        context.arg = new TypeError("iterator result is not an object");
-        context.delegate = null;
-        return ContinueSentinel;
-      }
-
-      if (info.done) {
-        // Assign the result of the finished delegate to the temporary
-        // variable specified by delegate.resultName (see delegateYield).
-        context[delegate.resultName] = info.value; // Resume execution at the desired location (see delegateYield).
-
-        context.next = delegate.nextLoc; // If context.method was "throw" but the delegate handled the
-        // exception, let the outer generator proceed normally. If
-        // context.method was "next", forget context.arg since it has been
-        // "consumed" by the delegate iterator. If context.method was
-        // "return", allow the original .return call to continue in the
-        // outer generator.
-
-        if (context.method !== "return") {
-          context.method = "next";
-          context.arg = undefined$1;
-        }
-      } else {
-        // Re-yield the result returned by the delegate method.
-        return info;
-      } // The delegate iterator is finished, so forget it and continue with
-      // the outer generator.
-
-
-      context.delegate = null;
-      return ContinueSentinel;
-    } // Define Generator.prototype.{next,throw,return} in terms of the
-    // unified ._invoke helper method.
-
-
-    defineIteratorMethods(Gp);
-    define(Gp, toStringTagSymbol, "Generator"); // A Generator should always return itself as the iterator object when the
-    // @@iterator function is called on it. Some browsers' implementations of the
-    // iterator prototype chain incorrectly implement this, causing the Generator
-    // object to not be returned from this call. This ensures that doesn't happen.
-    // See https://github.com/facebook/regenerator/issues/274 for more details.
-
-    define(Gp, iteratorSymbol, function () {
-      return this;
-    });
-    define(Gp, "toString", function () {
-      return "[object Generator]";
-    });
-
-    function pushTryEntry(locs) {
-      var entry = {
-        tryLoc: locs[0]
-      };
-
-      if (1 in locs) {
-        entry.catchLoc = locs[1];
-      }
-
-      if (2 in locs) {
-        entry.finallyLoc = locs[2];
-        entry.afterLoc = locs[3];
-      }
-
-      this.tryEntries.push(entry);
-    }
-
-    function resetTryEntry(entry) {
-      var record = entry.completion || {};
-      record.type = "normal";
-      delete record.arg;
-      entry.completion = record;
-    }
-
-    function Context(tryLocsList) {
-      // The root entry object (effectively a try statement without a catch
-      // or a finally block) gives us a place to store values thrown from
-      // locations where there is no enclosing try statement.
-      this.tryEntries = [{
-        tryLoc: "root"
-      }];
-      tryLocsList.forEach(pushTryEntry, this);
-      this.reset(true);
-    }
-
-    exports.keys = function (object) {
-      var keys = [];
-
-      for (var key in object) {
-        keys.push(key);
-      }
-
-      keys.reverse(); // Rather than returning an object with a next method, we keep
-      // things simple and return the next function itself.
-
-      return function next() {
-        while (keys.length) {
-          var key = keys.pop();
-
-          if (key in object) {
-            next.value = key;
-            next.done = false;
-            return next;
-          }
-        } // To avoid creating an additional object, we just hang the .value
-        // and .done properties off the next function object itself. This
-        // also ensures that the minifier will not anonymize the function.
-
-
-        next.done = true;
-        return next;
-      };
-    };
-
-    function values(iterable) {
-      if (iterable) {
-        var iteratorMethod = iterable[iteratorSymbol];
-
-        if (iteratorMethod) {
-          return iteratorMethod.call(iterable);
-        }
-
-        if (typeof iterable.next === "function") {
-          return iterable;
-        }
-
-        if (!isNaN(iterable.length)) {
-          var i = -1,
-              next = function next() {
-            while (++i < iterable.length) {
-              if (hasOwn.call(iterable, i)) {
-                next.value = iterable[i];
-                next.done = false;
-                return next;
-              }
-            }
-
-            next.value = undefined$1;
-            next.done = true;
-            return next;
-          };
-
-          return next.next = next;
-        }
-      } // Return an iterator with no values.
-
-
-      return {
-        next: doneResult
-      };
-    }
-
-    exports.values = values;
-
-    function doneResult() {
-      return {
-        value: undefined$1,
-        done: true
-      };
-    }
-
-    Context.prototype = {
-      constructor: Context,
-      reset: function reset(skipTempReset) {
-        this.prev = 0;
-        this.next = 0; // Resetting context._sent for legacy support of Babel's
-        // function.sent implementation.
-
-        this.sent = this._sent = undefined$1;
-        this.done = false;
-        this.delegate = null;
-        this.method = "next";
-        this.arg = undefined$1;
-        this.tryEntries.forEach(resetTryEntry);
-
-        if (!skipTempReset) {
-          for (var name in this) {
-            // Not sure about the optimal order of these conditions:
-            if (name.charAt(0) === "t" && hasOwn.call(this, name) && !isNaN(+name.slice(1))) {
-              this[name] = undefined$1;
-            }
-          }
-        }
-      },
-      stop: function stop() {
-        this.done = true;
-        var rootEntry = this.tryEntries[0];
-        var rootRecord = rootEntry.completion;
-
-        if (rootRecord.type === "throw") {
-          throw rootRecord.arg;
-        }
-
-        return this.rval;
-      },
-      dispatchException: function dispatchException(exception) {
-        if (this.done) {
-          throw exception;
-        }
-
-        var context = this;
-
-        function handle(loc, caught) {
-          record.type = "throw";
-          record.arg = exception;
-          context.next = loc;
-
-          if (caught) {
-            // If the dispatched exception was caught by a catch block,
-            // then let that catch block handle the exception normally.
-            context.method = "next";
-            context.arg = undefined$1;
-          }
-
-          return !!caught;
-        }
-
-        for (var i = this.tryEntries.length - 1; i >= 0; --i) {
-          var entry = this.tryEntries[i];
-          var record = entry.completion;
-
-          if (entry.tryLoc === "root") {
-            // Exception thrown outside of any try block that could handle
-            // it, so set the completion value of the entire function to
-            // throw the exception.
-            return handle("end");
-          }
-
-          if (entry.tryLoc <= this.prev) {
-            var hasCatch = hasOwn.call(entry, "catchLoc");
-            var hasFinally = hasOwn.call(entry, "finallyLoc");
-
-            if (hasCatch && hasFinally) {
-              if (this.prev < entry.catchLoc) {
-                return handle(entry.catchLoc, true);
-              } else if (this.prev < entry.finallyLoc) {
-                return handle(entry.finallyLoc);
-              }
-            } else if (hasCatch) {
-              if (this.prev < entry.catchLoc) {
-                return handle(entry.catchLoc, true);
-              }
-            } else if (hasFinally) {
-              if (this.prev < entry.finallyLoc) {
-                return handle(entry.finallyLoc);
-              }
-            } else {
-              throw new Error("try statement without catch or finally");
-            }
-          }
-        }
-      },
-      abrupt: function abrupt(type, arg) {
-        for (var i = this.tryEntries.length - 1; i >= 0; --i) {
-          var entry = this.tryEntries[i];
-
-          if (entry.tryLoc <= this.prev && hasOwn.call(entry, "finallyLoc") && this.prev < entry.finallyLoc) {
-            var finallyEntry = entry;
-            break;
-          }
-        }
-
-        if (finallyEntry && (type === "break" || type === "continue") && finallyEntry.tryLoc <= arg && arg <= finallyEntry.finallyLoc) {
-          // Ignore the finally entry if control is not jumping to a
-          // location outside the try/catch block.
-          finallyEntry = null;
-        }
-
-        var record = finallyEntry ? finallyEntry.completion : {};
-        record.type = type;
-        record.arg = arg;
-
-        if (finallyEntry) {
-          this.method = "next";
-          this.next = finallyEntry.finallyLoc;
-          return ContinueSentinel;
-        }
-
-        return this.complete(record);
-      },
-      complete: function complete(record, afterLoc) {
-        if (record.type === "throw") {
-          throw record.arg;
-        }
-
-        if (record.type === "break" || record.type === "continue") {
-          this.next = record.arg;
-        } else if (record.type === "return") {
-          this.rval = this.arg = record.arg;
-          this.method = "return";
-          this.next = "end";
-        } else if (record.type === "normal" && afterLoc) {
-          this.next = afterLoc;
-        }
-
-        return ContinueSentinel;
-      },
-      finish: function finish(finallyLoc) {
-        for (var i = this.tryEntries.length - 1; i >= 0; --i) {
-          var entry = this.tryEntries[i];
-
-          if (entry.finallyLoc === finallyLoc) {
-            this.complete(entry.completion, entry.afterLoc);
-            resetTryEntry(entry);
-            return ContinueSentinel;
-          }
-        }
-      },
-      "catch": function _catch(tryLoc) {
-        for (var i = this.tryEntries.length - 1; i >= 0; --i) {
-          var entry = this.tryEntries[i];
-
-          if (entry.tryLoc === tryLoc) {
-            var record = entry.completion;
-
-            if (record.type === "throw") {
-              var thrown = record.arg;
-              resetTryEntry(entry);
-            }
-
-            return thrown;
-          }
-        } // The context.catch method must only be called with a location
-        // argument that corresponds to a known catch block.
-
-
-        throw new Error("illegal catch attempt");
-      },
-      delegateYield: function delegateYield(iterable, resultName, nextLoc) {
-        this.delegate = {
-          iterator: values(iterable),
-          resultName: resultName,
-          nextLoc: nextLoc
-        };
-
-        if (this.method === "next") {
-          // Deliberately forget the last sent value so that we don't
-          // accidentally pass it on to the delegate.
-          this.arg = undefined$1;
-        }
-
-        return ContinueSentinel;
-      }
-    }; // Regardless of whether this script is executing as a CommonJS module
-    // or not, return the runtime object so that we can declare the variable
-    // regeneratorRuntime in the outer scope, which allows this module to be
-    // injected easily by `bin/regenerator --include-runtime script.js`.
-
-    return exports;
-  }( // If this script is executing as a CommonJS module, use module.exports
-  // as the regeneratorRuntime namespace. Otherwise create a new empty
-  // object. Either way, the resulting object will be used to initialize
-  // the regeneratorRuntime variable at the top of this file.
-   module.exports );
-
-  try {
-    regeneratorRuntime = runtime;
-  } catch (accidentalStrictMode) {
-    // This module should not be running in strict mode, so the above
-    // assignment should always work unless something is misconfigured. Just
-    // in case runtime.js accidentally runs in strict mode, in modern engines
-    // we can explicitly access globalThis. In older engines we can escape
-    // strict mode using a global Function call. This could conceivably fail
-    // if a Content Security Policy forbids using Function, but in that case
-    // the proper solution is to fix the accidental strict mode problem. If
-    // you've misconfigured your bundler to force strict mode and applied a
-    // CSP to forbid Function, and you're not willing to fix either of those
-    // problems, please detail your unique predicament in a GitHub issue.
-    if (typeof globalThis === "object") {
-      globalThis.regeneratorRuntime = runtime;
-    } else {
-      Function("r", "regeneratorRuntime = r")(runtime);
-    }
-  }
-});
-
-function linearVariantDisplayModelFactory (configSchema) {
-  return mobxStateTree.types.compose('LinearVariantDisplay', pluginLinearGenomeView.linearBasicDisplayModelFactory(configSchema), mobxStateTree.types.model({
-    type: mobxStateTree.types.literal('LinearVariantDisplay'),
-    configuration: configuration.ConfigurationReference(configSchema)
-  })).actions(function (self) {
-    return {
-      selectFeature: function selectFeature(feature) {
-        return _asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee() {
-          var session, rpcManager, sessionId, track, adapterConfig, header, featureWidget;
-          return runtime_1.wrap(function _callee$(_context) {
-            while (1) {
-              switch (_context.prev = _context.next) {
-                case 0:
-                  session = util.getSession(self);
-
-                  if (!util.isSessionModelWithWidgets(session)) {
-                    _context.next = 11;
-                    break;
-                  }
-
-                  rpcManager = session.rpcManager;
-                  sessionId = tracks.getRpcSessionId(self);
-                  track = util.getContainingTrack(self);
-                  adapterConfig = configuration.getConf(track, 'adapter');
-                  _context.next = 8;
-                  return rpcManager.call(sessionId, 'CoreGetMetadata', {
-                    adapterConfig: adapterConfig
-                  });
-
-                case 8:
-                  header = _context.sent;
-                  featureWidget = session.addWidget('VariantFeatureWidget', 'variantFeature', {
-                    featureData: feature.toJSON(),
-                    view: util.getContainingView(self),
-                    descriptions: header
-                  });
-                  session.showWidget(featureWidget);
-
-                case 11:
-                  session.setSelection(feature);
-
-                case 12:
-                case "end":
-                  return _context.stop();
-              }
-            }
-          }, _callee);
-        }))();
-      }
-    };
-  });
-}
-
-function bpToRadians(block, pos) {
-  var blockStart = block.region.elided ? 0 : block.region.start;
-  var blockEnd = block.region.elided ? 0 : block.region.end;
-  var bpOffset = block.flipped ? blockEnd - pos : pos - blockStart;
-  var radians = bpOffset / block.bpPerRadian + block.startRadians;
-  return radians;
-}
-
-var Chord = /*#__PURE__*/mobxReact.observer(function Chord(_ref) {
-  var _feature$get;
-
-  var feature = _ref.feature,
-      blocksForRefs = _ref.blocksForRefs,
-      radius = _ref.radius,
-      config = _ref.config,
-      bezierRadius = _ref.bezierRadius,
-      selected = _ref.selected,
-      _onClick = _ref.onClick;
-  // find the blocks that our start and end points belong to
-  var startBlock = blocksForRefs[feature.get('refName')];
-
-  if (!startBlock) {
-    return null;
-  }
-
-  var svType;
-
-  if (feature.get('INFO')) {
-
-    var _ref2 = feature.get('INFO').SVTYPE || [];
-
-    var _ref3 = _slicedToArray(_ref2, 1);
-
-    svType = _ref3[0];
-  } else if (feature.get('mate')) {
-    svType = 'mate';
-  }
-
-  var endPosition;
-  var endBlock;
-  var alt = (_feature$get = feature.get('ALT')) === null || _feature$get === void 0 ? void 0 : _feature$get[0];
-  var bnd = alt && VCF.parseBreakend(alt);
-
-  if (bnd) {
-    // VCF BND
-    var matePosition = bnd.MatePosition.split(':');
-    endPosition = +matePosition[1];
-    endBlock = blocksForRefs[matePosition[0]];
-  } else if (alt === '<TRA>') {
-    var _feature$get2, _feature$get2$CHR, _feature$get3, _feature$get3$END;
-
-    // VCF TRA
-    var chr2 = (_feature$get2 = feature.get('INFO')) === null || _feature$get2 === void 0 ? void 0 : (_feature$get2$CHR = _feature$get2.CHR2) === null || _feature$get2$CHR === void 0 ? void 0 : _feature$get2$CHR[0];
-    var end = (_feature$get3 = feature.get('INFO')) === null || _feature$get3 === void 0 ? void 0 : (_feature$get3$END = _feature$get3.END) === null || _feature$get3$END === void 0 ? void 0 : _feature$get3$END[0];
-    endPosition = parseInt(end, 10);
-    endBlock = blocksForRefs[chr2];
-  } else if (svType === 'mate') {
-    // generic simplefeatures arcs
-    var mate = feature.get('mate');
-    var _chr = mate.refName;
-    endPosition = mate.start;
-    endBlock = blocksForRefs[_chr];
-  }
-
-  if (endBlock) {
-    var startPos = feature.get('start');
-    var startRadians = bpToRadians(startBlock, startPos);
-    var endRadians = bpToRadians(endBlock, endPosition);
-    var startXY = util.polarToCartesian(radius, startRadians);
-    var endXY = util.polarToCartesian(radius, endRadians);
-    var controlXY = util.polarToCartesian(bezierRadius, (endRadians + startRadians) / 2);
-    var strokeColor = selected ? configuration.readConfObject(config, 'strokeColorSelected', {
-      feature: feature
-    }) : configuration.readConfObject(config, 'strokeColor', {
-      feature: feature
-    });
-    var hoverStrokeColor = configuration.readConfObject(config, 'strokeColorHover', {
-      feature: feature
-    });
-    return /*#__PURE__*/React__default.createElement("path", {
-      "data-testid": "chord-".concat(feature.id()),
-      d: ['M'].concat(_toConsumableArray(startXY), ['Q'], _toConsumableArray(controlXY), _toConsumableArray(endXY)).join(' '),
-      style: {
-        stroke: strokeColor
-      },
-      onClick: function onClick(evt) {
-        return _onClick(feature, startBlock.region, endBlock.region, evt);
-      },
-      onMouseOver: function onMouseOver(evt) {
-        if (!selected) {
-          evt.target.style.stroke = hoverStrokeColor;
-          evt.target.style.strokeWidth = 3;
-        }
-      },
-      onMouseOut: function onMouseOut(evt) {
-        if (!selected) {
-          evt.target.style.stroke = strokeColor;
-          evt.target.style.strokeWidth = 1;
-        }
-      }
-    });
-  }
-
-  return null;
-});
-
-function StructuralVariantChords(props) {
-  var features = props.features,
-      config = props.config,
-      displayModel = props.displayModel,
-      blockDefinitions = props.blockDefinitions,
-      radius = props.radius,
-      bezierRadius = props.bezierRadius,
-      selectedFeatureId = props.displayModel.selectedFeatureId,
-      onChordClick = props.onChordClick; // make a map of refName -> blockDefinition
-
-  var blocksForRefsMemo = React.useMemo(function () {
-    var blocksForRefs = {};
-    blockDefinitions.forEach(function (block) {
-      var regions = block.region.elided ? block.region.regions : [block.region];
-      regions.forEach(function (region) {
-        blocksForRefs[region.refName] = block;
-      });
-    });
-    return blocksForRefs;
-  }, [blockDefinitions]); // console.log(blocksForRefs)
-
-  var chords = [];
-
-  var _iterator = _createForOfIteratorHelper(features),
-      _step;
-
-  try {
-    for (_iterator.s(); !(_step = _iterator.n()).done;) {
-      var _step$value = _slicedToArray(_step.value, 2),
-          id = _step$value[0],
-          feature = _step$value[1];
-
-      var selected = String(selectedFeatureId) === String(feature.id());
-      chords.push( /*#__PURE__*/React__default.createElement(Chord, {
-        key: id,
-        feature: feature,
-        config: config,
-        displayModel: displayModel,
-        radius: radius,
-        bezierRadius: bezierRadius,
-        blocksForRefs: blocksForRefsMemo,
-        selected: selected,
-        onClick: onChordClick
-      }));
-    }
-  } catch (err) {
-    _iterator.e(err);
-  } finally {
-    _iterator.f();
-  }
-
-  var trackStyleId = "chords-".concat(displayModel.id);
-  return /*#__PURE__*/React__default.createElement("g", {
-    id: trackStyleId,
-    "data-testid": "structuralVariantChordRenderer"
-  }, /*#__PURE__*/React__default.createElement("style", {
-    // eslint-disable-next-line react/no-danger
-    dangerouslySetInnerHTML: {
-      __html: "\n          #".concat(trackStyleId, " > path {\n            cursor: crosshair;\n            fill: none;\n          }\n")
-    }
-  }), chords);
-}
-
-StructuralVariantChords.propTypes = {
-  features: /*#__PURE__*/PropTypes.instanceOf(Map).isRequired,
-  config: mst.PropTypes.ConfigSchema.isRequired,
-  displayModel: mobxReact.PropTypes.objectOrObservableObject,
-  blockDefinitions: /*#__PURE__*/PropTypes.arrayOf(mobxReact.PropTypes.objectOrObservableObject).isRequired,
-  radius: PropTypes.number.isRequired,
-  bezierRadius: PropTypes.number.isRequired,
-  selectedFeatureId: PropTypes.string,
-  onChordClick: /*#__PURE__*/PropTypes.oneOfType([PropTypes.func, PropTypes.string])
-};
-StructuralVariantChords.defaultProps = {
-  displayModel: undefined,
-  selectedFeatureId: '',
-  onChordClick: undefined
-};
-var ReactComponent = /*#__PURE__*/mobxReact.observer(StructuralVariantChords);
-
-var ChordRendererConfigF = function ChordRendererConfigF(pluginManager) {
-  var configSchema = configuration.ConfigurationSchema('StructuralVariantChordRenderer', {
-    strokeColor: {
-      type: 'color',
-      description: 'the line color of each arc',
-      defaultValue: 'rgba(255,133,0,0.32)',
-      contextVariable: ['feature']
-    },
-    strokeColorSelected: {
-      type: 'color',
-      description: 'the line color of an arc that has been selected',
-      defaultValue: 'black',
-      contextVariable: ['feature']
-    },
-    strokeColorHover: {
-      type: 'color',
-      description: 'the line color of an arc that is being hovered over with the mouse',
-      defaultValue: '#555',
-      contextVariable: ['feature']
-    }
-  }, {
-    explicitlyTyped: true
-  });
-  return new ChordRendererType({
-    name: 'StructuralVariantChordRenderer',
-    ReactComponent: ReactComponent,
-    configSchema: configSchema,
-    pluginManager: pluginManager
-  });
-};
-
-var configSchema = /*#__PURE__*/configuration.ConfigurationSchema('VariantFeatureWidget', {});
-function stateModelFactory(pluginManager) {
-  return mobxStateTree.types.model('VariantFeatureWidget', {
-    id: mst.ElementId,
-    type: mobxStateTree.types.literal('VariantFeatureWidget'),
-    view: mobxStateTree.types.safeReference(pluginManager.pluggableMstType('view', 'stateModel')),
-    featureData: mobxStateTree.types.frozen(),
-    descriptions: mobxStateTree.types.frozen()
-  }).actions(function (self) {
-    return {
-      setFeatureData: function setFeatureData(data) {
-        self.featureData = data;
-      },
-      clearFeatureData: function clearFeatureData() {
-        self.featureData = undefined;
-      }
-    };
-  });
-}
-
-var vcfTabixAdapterConfigSchema = /*#__PURE__*/configuration.ConfigurationSchema('VcfTabixAdapter', {
-  vcfGzLocation: {
-    type: 'fileLocation',
-    defaultValue: {
-      uri: '/path/to/my.vcf.gz',
-      locationType: 'UriLocation'
-    }
-  },
-  index: /*#__PURE__*/configuration.ConfigurationSchema('VcfIndex', {
-    indexType: {
-      model: /*#__PURE__*/mobxStateTree.types.enumeration('IndexType', ['TBI', 'CSI']),
-      type: 'stringEnum',
-      defaultValue: 'TBI'
-    },
-    location: {
-      type: 'fileLocation',
-      defaultValue: {
-        uri: '/path/to/my.vcf.gz.tbi',
-        locationType: 'UriLocation'
-      }
-    }
-  })
-}, {
-  explicitlyTyped: true
-});
-
-var vcfAdapterConfigSchema = /*#__PURE__*/configuration.ConfigurationSchema('VcfAdapter', {
-  vcfLocation: {
-    type: 'fileLocation',
-    defaultValue: {
-      uri: '/path/to/my.vcf',
-      locationType: 'UriLocation'
-    }
-  }
-}, {
-  explicitlyTyped: true
-});
-
-var VCFFeature = /*#__PURE__*/function () {
-  // eslint-disable-next-line @typescript-eslint/no-explicit-any
-  function VCFFeature(args) {
-    _classCallCheck(this, VCFFeature);
-
-    this.variant = args.variant;
-    this.parser = args.parser;
-    this.data = this.dataFromVariant(this.variant);
-    this._id = args.id;
-  } // eslint-disable-next-line @typescript-eslint/no-explicit-any
-
-
-  _createClass(VCFFeature, [{
-    key: "get",
-    value: function get(field) {
-      return field === 'samples' ? this.variant.SAMPLES : this.data[field] || this.variant[field];
-    }
-  }, {
-    key: "set",
-    value: function set() {}
-  }, {
-    key: "parent",
-    value: function parent() {
-      return undefined;
-    }
-  }, {
-    key: "children",
-    value: function children() {
-      return undefined;
-    }
-  }, {
-    key: "tags",
-    value: function tags() {
-      var t = [].concat(_toConsumableArray(Object.keys(this.data)), _toConsumableArray(Object.keys(this.variant)), ['samples']);
-      return t;
-    }
-  }, {
-    key: "id",
-    value: function id() {
-      return this._id;
-    }
-  }, {
-    key: "dataFromVariant",
-    value: function dataFromVariant(variant) {
-      var REF = variant.REF,
-          ALT = variant.ALT,
-          POS = variant.POS,
-          CHROM = variant.CHROM,
-          INFO = variant.INFO,
-          ID = variant.ID;
-      var start = POS - 1;
-
-      var _this$_getSOTermAndDe = this._getSOTermAndDescription(REF, ALT),
-          _this$_getSOTermAndDe2 = _slicedToArray(_this$_getSOTermAndDe, 2),
-          SO_term = _this$_getSOTermAndDe2[0],
-          description = _this$_getSOTermAndDe2[1];
-
-      var isTRA = ALT === null || ALT === void 0 ? void 0 : ALT.some(function (f) {
-        return f === '<TRA>';
-      });
-      var isSymbolic = ALT === null || ALT === void 0 ? void 0 : ALT.some(function (f) {
-        return f.indexOf('<') !== -1;
-      });
-      return {
-        refName: CHROM,
-        start: start,
-        end: isSymbolic && INFO.END && !isTRA ? +INFO.END[0] : start + REF.length,
-        description: description,
-        type: SO_term,
-        name: ID === null || ID === void 0 ? void 0 : ID.join(','),
-        aliases: ID && ID.length > 1 ? variant.ID.slice(1) : undefined
-      };
-    }
-    /**
-     * Get a sequence ontology (SO) term that describes the variant type
-     */
-
-  }, {
-    key: "_getSOTermAndDescription",
-    value: function _getSOTermAndDescription(ref, alt) {
-      var _this = this;
-
-      // it's just a remark if there are no alternate alleles
-      if (!alt || alt === []) {
-        return ['remark', 'no alternative alleles'];
-      }
-
-      var soTerms = new Set();
-      var descriptions = new Set();
-      alt.forEach(function (a) {
-        var _this$_getSOAndDescFr = _this._getSOAndDescFromAltDefs(ref, a),
-            _this$_getSOAndDescFr2 = _slicedToArray(_this$_getSOAndDescFr, 2),
-            soTerm = _this$_getSOAndDescFr2[0],
-            description = _this$_getSOAndDescFr2[1];
-
-        if (!soTerm) {
-
-          var _this$_getSOAndDescBy = _this._getSOAndDescByExamination(ref, a);
-
-          var _this$_getSOAndDescBy2 = _slicedToArray(_this$_getSOAndDescBy, 2);
-
-          soTerm = _this$_getSOAndDescBy2[0];
-          description = _this$_getSOAndDescBy2[1];
-        }
-
-        if (soTerm && description) {
-          soTerms.add(soTerm);
-          descriptions.add(description);
-        }
-      }); // Combine descriptions like ["SNV G -> A", "SNV G -> T"] to ["SNV G -> A,T"]
-
-      if (descriptions.size > 1) {
-        var prefixes = new Set(_toConsumableArray(descriptions).map(function (desc) {
-          var prefix = desc.split('->');
-          return prefix[1] ? prefix[0] : desc;
-        }));
-
-        var new_descs = _toConsumableArray(prefixes).map(function (prefix) {
-          var suffixes = _toConsumableArray(descriptions).map(function (desc) {
-            var pref = desc.split('-> ');
-            return pref[1] && pref[0] === prefix ? pref[1] : '';
-          }).filter(function (f) {
-            return !!f;
-          });
-
-          return suffixes.length ? prefix + '-> ' + suffixes.join(',') : _toConsumableArray(descriptions).join(',');
-        });
-
-        descriptions = new Set(new_descs);
-      }
-
-      if (soTerms.size) {
-        return [_toConsumableArray(soTerms).join(','), _toConsumableArray(descriptions).join(',')];
-      }
-
-      return [undefined, undefined];
-    }
-  }, {
-    key: "_getSOAndDescFromAltDefs",
-    value: function _getSOAndDescFromAltDefs(ref, alt) {
-      if (typeof alt === 'string' && !alt.startsWith('<')) {
-        return [undefined, undefined];
-      } // look for a definition with an SO type for this
-
-
-      var soTerm = VCFFeature._altTypeToSO[alt]; // if no SO term but ALT is in metadata, assume sequence_variant
-
-      if (!soTerm && this.parser.getMetadata('ALT', alt)) {
-        soTerm = 'sequence_variant';
-      }
-
-      if (soTerm) {
-        return [soTerm, alt];
-      } // try to look for a definition for a parent term if we can
-
-
-      var modAlt = alt.split(':');
-
-      if (modAlt.length > 1) {
-        return this._getSOAndDescFromAltDefs(ref, "<".concat(modAlt.slice(0, modAlt.length - 1).join(':'), ">"));
-      } // no parent
-
-
-      return [undefined, undefined];
-    } // note: term SNV is used instead of SNP because SO definition of SNP says
-    // abundance must be at least 1% in population, and can't be sure we meet
-    // that
-
-  }, {
-    key: "_getSOAndDescByExamination",
-    value: function _getSOAndDescByExamination(ref, alt) {
-      var bnd = VCF.parseBreakend(alt);
-
-      if (bnd) {
-        return ['breakend', alt];
-      } else if (ref.length === 1 && alt.length === 1) {
-        return ['SNV', this._makeDescriptionString('SNV', ref, alt)];
-      } else if (alt === '<INS>') {
-        return ['insertion', alt];
-      } else if (alt === '<DEL>') {
-        return ['deletion', alt];
-      } else if (alt === '<INV>') {
-        return ['deletion', alt];
-      } else if (alt === '<TRA>') {
-        return ['translocation', alt];
-      } else if (alt.includes('<')) {
-        return ['sv', alt];
-      } else if (ref.length === alt.length) {
-        if (ref.split('').reverse().join('') === alt) {
-          return ['inversion', this._makeDescriptionString('inversion', ref, alt)];
-        }
-
-        return ['substitution', this._makeDescriptionString('substitution', ref, alt)];
-      } else if (ref.length <= alt.length) {
-        return ['insertion', this._makeDescriptionString('insertion', ref, alt)];
-      } else if (ref.length > alt.length) {
-        return ['deletion', this._makeDescriptionString('deletion', ref, alt)];
-      }
-
-      return ['indel', this._makeDescriptionString('indel', ref, alt)];
-    }
-  }, {
-    key: "_makeDescriptionString",
-    value: function _makeDescriptionString(soTerm, ref, alt) {
-      return "".concat(soTerm, " ").concat(ref, " -> ").concat(alt);
-    } // eslint-disable-next-line @typescript-eslint/no-explicit-any
-
-  }, {
-    key: "toJSON",
-    value: function toJSON() {
-      return _objectSpread2(_objectSpread2(_objectSpread2({
-        uniqueId: this._id
-      }, this.variant), this.data), {}, {
-        samples: this.variant.SAMPLES
-      });
-    }
-  }]);
-
-  return VCFFeature;
-}();
-VCFFeature._altTypeToSO = {
-  DEL: 'deletion',
-  INS: 'insertion',
-  DUP: 'duplication',
-  INV: 'inversion',
-  INVDUP: 'inverted duplication',
-  CNV: 'copy_number_variation',
-  TRA: 'translocation',
-  'DUP:TANDEM': 'tandem_duplication',
-  NON_REF: 'sequence_variant',
-  '*': 'sequence_variant'
-};
-
-var VariantsPlugin = /*#__PURE__*/function (_Plugin) {
-  _inherits(VariantsPlugin, _Plugin);
-
-  var _super = /*#__PURE__*/_createSuper(VariantsPlugin);
-
-  function VariantsPlugin() {
-    var _this;
-
-    _classCallCheck(this, VariantsPlugin);
-
-    _this = _super.apply(this, arguments);
-    _this.name = 'VariantsPlugin';
-    return _this;
-  }
-
-  _createClass(VariantsPlugin, [{
-    key: "install",
-    value: function install(pluginManager) {
-      pluginManager.addAdapterType(function () {
-        return new AdapterType({
-          name: 'VcfTabixAdapter',
-          configSchema: vcfTabixAdapterConfigSchema,
-          getAdapterClass: function getAdapterClass() {
-            return Promise.resolve().then(function () { return VcfTabixAdapter; }).then(function (r) {
-              return r["default"];
-            });
-          }
-        });
-      });
-      pluginManager.addToExtensionPoint('Core-guessAdapterForLocation', function (adapterGuesser) {
-        return function (file, index, adapterHint) {
-          var regexGuess = /\.vcf\.b?gz$/i;
-          var adapterName = 'VcfTabixAdapter';
-          var fileName = tracks.getFileName(file);
-          var indexName = index && tracks.getFileName(index);
-          var obj = {
-            type: adapterName,
-            vcfGzLocation: file,
-            index: {
-              location: index || tracks.makeIndex(file, '.tbi'),
-              indexType: tracks.makeIndexType(indexName, 'CSI', 'TBI')
-            }
-          };
-
-          if (regexGuess.test(fileName) && !adapterHint) {
-            return obj;
-          } else if (adapterHint === adapterName) {
-            return obj;
-          }
-
-          return adapterGuesser(file, index, adapterHint);
-        };
-      });
-      pluginManager.addToExtensionPoint('Core-guessTrackTypeForLocation', function (trackTypeGuesser) {
-        return function (adapterName) {
-          if (adapterName === 'VcfTabixAdapter' || adapterName === 'VcfAdapter') {
-            return 'VariantTrack';
-          }
-
-          return trackTypeGuesser(adapterName);
-        };
-      });
-      pluginManager.addAdapterType(function () {
-        return new AdapterType({
-          name: 'VcfAdapter',
-          configSchema: vcfAdapterConfigSchema,
-          getAdapterClass: function getAdapterClass() {
-            return Promise.resolve().then(function () { return VcfAdapter$1; }).then(function (r) {
-              return r["default"];
-            });
-          }
-        });
-      });
-      pluginManager.addToExtensionPoint('Core-guessAdapterForLocation', function (adapterGuesser) {
-        return function (file, index, adapterHint) {
-          var regexGuess = /\.vcf$/i;
-          var adapterName = 'VcfAdapter';
-          var fileName = tracks.getFileName(file);
-
-          if (regexGuess.test(fileName) || adapterHint === adapterName) {
-            return {
-              type: adapterName,
-              vcfLocation: file
-            };
-          }
-
-          return adapterGuesser(file, index, adapterHint);
-        };
-      });
-      pluginManager.addRendererType(function () {
-        return pluginManager.jbrequire(ChordRendererConfigF);
-      });
-      pluginManager.addTrackType(function () {
-        var configSchema = configuration.ConfigurationSchema('VariantTrack', {}, {
-          baseConfiguration: models.createBaseTrackConfig(pluginManager)
-        });
-        return new TrackType({
-          name: 'VariantTrack',
-          configSchema: configSchema,
-          stateModel: models.createBaseTrackModel(pluginManager, 'VariantTrack', configSchema)
-        });
-      });
-      pluginManager.addDisplayType(function () {
-        return pluginManager.jbrequire(ChordVariantDisplay);
-      });
-      pluginManager.addDisplayType(function () {
-        var configSchema = LinearVariantDisplayConfigFactory(pluginManager);
-        return new DisplayType({
-          name: 'LinearVariantDisplay',
-          configSchema: configSchema,
-          stateModel: linearVariantDisplayModelFactory(configSchema),
-          trackType: 'VariantTrack',
-          viewType: 'LinearGenomeView',
-          ReactComponent: pluginLinearGenomeView.BaseLinearDisplayComponent
-        });
-      });
-      pluginManager.addWidgetType(function () {
-        return new WidgetType({
-          name: 'VariantFeatureWidget',
-          heading: 'Feature details',
-          configSchema: configSchema,
-          stateModel: stateModelFactory(pluginManager),
-          ReactComponent: /*#__PURE__*/React.lazy(function () {
-            return Promise.resolve().then(function () { return VariantFeatureWidget$1; });
-          })
-        });
-      });
-    }
-  }]);
-
-  return VariantsPlugin;
-}(Plugin);
-
-var _default = /*#__PURE__*/function (_BaseFeatureDataAdapt) {
-  _inherits(_default, _BaseFeatureDataAdapt);
-
-  var _super = /*#__PURE__*/_createSuper(_default);
-
-  function _default() {
-    _classCallCheck(this, _default);
-
-    return _super.apply(this, arguments);
-  }
-
-  _createClass(_default, [{
-    key: "configurePre",
-    value: function () {
-      var _configurePre = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee() {
-        var vcfGzLocation, location, indexType, filehandle, isCSI, vcf, header;
-        return runtime_1.wrap(function _callee$(_context) {
-          while (1) {
-            switch (_context.prev = _context.next) {
-              case 0:
-                vcfGzLocation = configuration.readConfObject(this.config, 'vcfGzLocation');
-                location = configuration.readConfObject(this.config, ['index', 'location']);
-                indexType = configuration.readConfObject(this.config, ['index', 'indexType']);
-                filehandle = io.openLocation(vcfGzLocation, this.pluginManager);
-                isCSI = indexType === 'CSI';
-                vcf = new tabix.TabixIndexedFile({
-                  filehandle: filehandle,
-                  csiFilehandle: isCSI ? io.openLocation(location, this.pluginManager) : undefined,
-                  tbiFilehandle: !isCSI ? io.openLocation(location, this.pluginManager) : undefined,
-                  chunkCacheSize: 50 * Math.pow(2, 20),
-                  chunkSizeLimit: 1000000000
-                });
-                _context.next = 8;
-                return vcf.getHeader();
-
-              case 8:
-                header = _context.sent;
-                return _context.abrupt("return", {
-                  filehandle: filehandle,
-                  vcf: vcf,
-                  parser: new VCF__default({
-                    header: header
-                  })
-                });
-
-              case 10:
-              case "end":
-                return _context.stop();
-            }
-          }
-        }, _callee, this);
-      }));
-
-      function configurePre() {
-        return _configurePre.apply(this, arguments);
-      }
-
-      return configurePre;
-    }()
-  }, {
-    key: "configure",
-    value: function () {
-      var _configure = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee2() {
-        var _this = this;
-
-        return runtime_1.wrap(function _callee2$(_context2) {
-          while (1) {
-            switch (_context2.prev = _context2.next) {
-              case 0:
-                if (!this.configured) {
-                  this.configured = this.configurePre()["catch"](function (e) {
-                    _this.configured = undefined;
-                    throw e;
-                  });
-                }
-
-                return _context2.abrupt("return", this.configured);
-
-              case 2:
-              case "end":
-                return _context2.stop();
-            }
-          }
-        }, _callee2, this);
-      }));
-
-      function configure() {
-        return _configure.apply(this, arguments);
-      }
-
-      return configure;
-    }()
-  }, {
-    key: "getRefNames",
-    value: function () {
-      var _getRefNames = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee3() {
-        var opts,
-            _yield$this$configure,
-            vcf,
-            _args3 = arguments;
-
-        return runtime_1.wrap(function _callee3$(_context3) {
-          while (1) {
-            switch (_context3.prev = _context3.next) {
-              case 0:
-                opts = _args3.length > 0 && _args3[0] !== undefined ? _args3[0] : {};
-                _context3.next = 3;
-                return this.configure();
-
-              case 3:
-                _yield$this$configure = _context3.sent;
-                vcf = _yield$this$configure.vcf;
-                return _context3.abrupt("return", vcf.getReferenceSequenceNames(opts));
-
-              case 6:
-              case "end":
-                return _context3.stop();
-            }
-          }
-        }, _callee3, this);
-      }));
-
-      function getRefNames() {
-        return _getRefNames.apply(this, arguments);
-      }
-
-      return getRefNames;
-    }()
-  }, {
-    key: "getHeader",
-    value: function () {
-      var _getHeader = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee4() {
-        var _yield$this$configure2, vcf;
-
-        return runtime_1.wrap(function _callee4$(_context4) {
-          while (1) {
-            switch (_context4.prev = _context4.next) {
-              case 0:
-                _context4.next = 2;
-                return this.configure();
-
-              case 2:
-                _yield$this$configure2 = _context4.sent;
-                vcf = _yield$this$configure2.vcf;
-                return _context4.abrupt("return", vcf.getHeader());
-
-              case 5:
-              case "end":
-                return _context4.stop();
-            }
-          }
-        }, _callee4, this);
-      }));
-
-      function getHeader() {
-        return _getHeader.apply(this, arguments);
-      }
-
-      return getHeader;
-    }()
-  }, {
-    key: "getMetadata",
-    value: function () {
-      var _getMetadata = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee5() {
-        var _yield$this$configure3, parser;
-
-        return runtime_1.wrap(function _callee5$(_context5) {
-          while (1) {
-            switch (_context5.prev = _context5.next) {
-              case 0:
-                _context5.next = 2;
-                return this.configure();
-
-              case 2:
-                _yield$this$configure3 = _context5.sent;
-                parser = _yield$this$configure3.parser;
-                return _context5.abrupt("return", parser.getMetadata());
-
-              case 5:
-              case "end":
-                return _context5.stop();
-            }
-          }
-        }, _callee5, this);
-      }));
-
-      function getMetadata() {
-        return _getMetadata.apply(this, arguments);
-      }
-
-      return getMetadata;
-    }()
-  }, {
-    key: "getFeatures",
-    value: function getFeatures(query) {
-      var _this2 = this;
-
-      var opts = arguments.length > 1 && arguments[1] !== undefined ? arguments[1] : {};
-      return rxjs.ObservableCreate( /*#__PURE__*/function () {
-        var _ref = _asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee6(observer) {
-          var refName, start, end, _yield$_this2$configu, vcf, parser;
-
-          return runtime_1.wrap(function _callee6$(_context6) {
-            while (1) {
-              switch (_context6.prev = _context6.next) {
-                case 0:
-                  refName = query.refName, start = query.start, end = query.end;
-                  _context6.next = 3;
-                  return _this2.configure();
-
-                case 3:
-                  _yield$_this2$configu = _context6.sent;
-                  vcf = _yield$_this2$configu.vcf;
-                  parser = _yield$_this2$configu.parser;
-                  _context6.next = 8;
-                  return vcf.getLines(refName, start, end, _objectSpread2({
-                    lineCallback: function lineCallback(line, fileOffset) {
-                      observer.next(new VCFFeature({
-                        variant: parser.parseLine(line),
-                        parser: parser,
-                        id: "".concat(_this2.id, "-vcf-").concat(fileOffset)
-                      }));
-                    }
-                  }, opts));
-
-                case 8:
-                  observer.complete();
-
-                case 9:
-                case "end":
-                  return _context6.stop();
-              }
-            }
-          }, _callee6);
-        }));
-
-        return function (_x) {
-          return _ref.apply(this, arguments);
-        };
-      }(), opts.signal);
-    }
-    /**
-     * Checks if the data source has data for the given reference sequence,
-     * and then gets the features in the region if it does
-     *
-     * Currently this just calls getFeatureInRegion for each region. Adapters that
-     * are frequently called on multiple regions simultaneously may want to
-     * implement a more efficient custom version of this method.
-     *
-     * Also includes a bit of extra logging to warn when fetching a large portion
-     * of a VCF
-     * @param regions - Regions
-     * @param opts - Feature adapter options
-     * @returns Observable of Feature objects in the regions
-     */
-
-  }, {
-    key: "getFeaturesInMultipleRegions",
-    value: function getFeaturesInMultipleRegions(regions) {
-      var _this3 = this;
-
-      var opts = arguments.length > 1 && arguments[1] !== undefined ? arguments[1] : {};
-
-      // TODO: restore commented version below once TSDX supports Rollup v2
-      // xref: https://github.com/rollup/rollup/blob/master/CHANGELOG.md#bug-fixes-45
-      var superGetFeaturesInMultipleRegions = _get(_getPrototypeOf(_default.prototype), "getFeaturesInMultipleRegions", this);
-
-      return rxjs.ObservableCreate( /*#__PURE__*/function () {
-        var _ref2 = _asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee7(observer) {
-          var _yield$_this3$configu, vcf, bytes, _yield$_this3$configu2, filehandle, stat, pct;
-
-          return runtime_1.wrap(function _callee7$(_context7) {
-            while (1) {
-              switch (_context7.prev = _context7.next) {
-                case 0:
-                  _context7.next = 2;
-                  return _this3.configure();
-
-                case 2:
-                  _yield$_this3$configu = _context7.sent;
-                  vcf = _yield$_this3$configu.vcf;
-                  _context7.next = 6;
-                  return util.bytesForRegions(regions, vcf.index);
-
-                case 6:
-                  bytes = _context7.sent;
-                  _context7.next = 9;
-                  return _this3.configure();
-
-                case 9:
-                  _yield$_this3$configu2 = _context7.sent;
-                  filehandle = _yield$_this3$configu2.filehandle;
-                  _context7.next = 13;
-                  return filehandle.stat();
-
-                case 13:
-                  stat = _context7.sent;
-                  pct = Math.round(bytes / stat.size * 100);
-
-                  if (pct > 100) {
-                    // this is just a bad estimate, make 100% if it goes over
-                    pct = 100;
-                  }
-
-                  if (pct > 60) {
-                    console.warn("getFeaturesInMultipleRegions fetching ".concat(pct, "% of VCF file, but whole-file streaming not yet implemented"));
-                  }
-
-                  superGetFeaturesInMultipleRegions.call(_this3, regions, opts).subscribe(observer); // super.getFeaturesInMultipleRegions(regions, opts).subscribe(observer)
-
-                case 18:
-                case "end":
-                  return _context7.stop();
-              }
-            }
-          }, _callee7);
-        }));
-
-        return function (_x2) {
-          return _ref2.apply(this, arguments);
-        };
-      }());
-    }
-  }, {
-    key: "freeResources",
-    value: function
-      /* { region } */
-    freeResources() {}
-  }]);
-
-  return _default;
-}(BaseAdapter.BaseFeatureDataAdapter);
-
-var VcfTabixAdapter = {
-  __proto__: null,
-  'default': _default
-};
-
-var readVcf = function readVcf(f) {
-  var lines = f.split('\n');
-  var header = [];
-  var rest = [];
-  lines.forEach(function (line) {
-    if (line.startsWith('#')) {
-      header.push(line);
-    } else if (line) {
-      rest.push(line);
-    }
-  });
-  return {
-    header: header.join('\n'),
-    lines: rest
-  };
-};
-
-function isGzip(buf) {
-  return buf[0] === 31 && buf[1] === 139 && buf[2] === 8;
-}
-
-var VcfAdapter = /*#__PURE__*/function (_BaseFeatureDataAdapt) {
-  _inherits(VcfAdapter, _BaseFeatureDataAdapt);
-
-  var _super = /*#__PURE__*/_createSuper(VcfAdapter);
-
-  function VcfAdapter() {
-    _classCallCheck(this, VcfAdapter);
-
-    return _super.apply(this, arguments);
-  }
-
-  _createClass(VcfAdapter, [{
-    key: "getHeader",
-    value: function () {
-      var _getHeader = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee() {
-        var _yield$this$setup, header;
-
-        return runtime_1.wrap(function _callee$(_context) {
-          while (1) {
-            switch (_context.prev = _context.next) {
-              case 0:
-                _context.next = 2;
-                return this.setup();
-
-              case 2:
-                _yield$this$setup = _context.sent;
-                header = _yield$this$setup.header;
-                return _context.abrupt("return", header);
-
-              case 5:
-              case "end":
-                return _context.stop();
-            }
-          }
-        }, _callee, this);
-      }));
-
-      function getHeader() {
-        return _getHeader.apply(this, arguments);
-      }
-
-      return getHeader;
-    }()
-  }, {
-    key: "getMetadata",
-    value: function () {
-      var _getMetadata = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee2() {
-        var _yield$this$setup2, header, parser;
-
-        return runtime_1.wrap(function _callee2$(_context2) {
-          while (1) {
-            switch (_context2.prev = _context2.next) {
-              case 0:
-                _context2.next = 2;
-                return this.setup();
-
-              case 2:
-                _yield$this$setup2 = _context2.sent;
-                header = _yield$this$setup2.header;
-                parser = new VCF__default({
-                  header: header
-                });
-                return _context2.abrupt("return", parser.getMetadata());
-
-              case 6:
-              case "end":
-                return _context2.stop();
-            }
-          }
-        }, _callee2, this);
-      }));
-
-      function getMetadata() {
-        return _getMetadata.apply(this, arguments);
-      }
-
-      return getMetadata;
-    }() // converts lines into an interval tree
-
-  }, {
-    key: "setupP",
-    value: function () {
-      var _setupP = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee3() {
-        var buffer, buf, str, _readVcf, header, lines, intervalTree;
-
-        return runtime_1.wrap(function _callee3$(_context3) {
-          while (1) {
-            switch (_context3.prev = _context3.next) {
-              case 0:
-                _context3.next = 2;
-                return io.openLocation(configuration.readConfObject(this.config, 'vcfLocation'), this.pluginManager).readFile();
-
-              case 2:
-                buffer = _context3.sent;
-
-                if (!isGzip(buffer)) {
-                  _context3.next = 9;
-                  break;
-                }
-
-                _context3.next = 6;
-                return bgzfFilehandle.unzip(buffer);
-
-              case 6:
-                _context3.t0 = _context3.sent;
-                _context3.next = 10;
-                break;
-
-              case 9:
-                _context3.t0 = buffer;
-
-              case 10:
-                buf = _context3.t0;
-
-                if (!(buf.length > 536870888)) {
-                  _context3.next = 13;
-                  break;
-                }
-
-                throw new Error('Data exceeds maximum string length (512MB)');
-
-              case 13:
-                str = new TextDecoder().decode(buf);
-                _readVcf = readVcf(str), header = _readVcf.header, lines = _readVcf.lines;
-                intervalTree = lines.map(function (line, id) {
-                  var _info$match;
-
-                  var _line$split = line.split('\t'),
-                      _line$split2 = _slicedToArray(_line$split, 8),
-                      refName = _line$split2[0],
-                      startP = _line$split2[1],
-                      ref = _line$split2[3],
-                      info = _line$split2[7];
-
-                  var start = +startP - 1;
-                  var end = +(((_info$match = info.match(/END=(\d+)/)) === null || _info$match === void 0 ? void 0 : _info$match[1].trim()) || start + ref.length);
-                  return {
-                    line: line,
-                    refName: refName,
-                    start: start,
-                    end: end,
-                    id: id
-                  };
-                }).reduce(function (acc, obj) {
-                  var key = obj.refName;
-
-                  if (!acc[key]) {
-                    acc[key] = new IntervalTree();
-                  }
-
-                  acc[key].insert([obj.start, obj.end], obj);
-                  return acc;
-                }, {});
-                return _context3.abrupt("return", {
-                  header: header,
-                  intervalTree: intervalTree
-                });
-
-              case 17:
-              case "end":
-                return _context3.stop();
-            }
-          }
-        }, _callee3, this);
-      }));
-
-      function setupP() {
-        return _setupP.apply(this, arguments);
-      }
-
-      return setupP;
-    }()
-  }, {
-    key: "setup",
-    value: function () {
-      var _setup = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee4() {
-        var _this = this;
-
-        return runtime_1.wrap(function _callee4$(_context4) {
-          while (1) {
-            switch (_context4.prev = _context4.next) {
-              case 0:
-                if (!this.vcfFeatures) {
-                  this.vcfFeatures = this.setupP()["catch"](function (e) {
-                    _this.vcfFeatures = undefined;
-                    throw e;
-                  });
-                }
-
-                return _context4.abrupt("return", this.vcfFeatures);
-
-              case 2:
-              case "end":
-                return _context4.stop();
-            }
-          }
-        }, _callee4, this);
-      }));
-
-      function setup() {
-        return _setup.apply(this, arguments);
-      }
-
-      return setup;
-    }()
-  }, {
-    key: "getRefNames",
-    value: function () {
-      var _getRefNames = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee5() {
-        var _yield$this$setup3,
-            intervalTree;
-
-        return runtime_1.wrap(function _callee5$(_context5) {
-          while (1) {
-            switch (_context5.prev = _context5.next) {
-              case 0:
-                _context5.next = 3;
-                return this.setup();
-
-              case 3:
-                _yield$this$setup3 = _context5.sent;
-                intervalTree = _yield$this$setup3.intervalTree;
-                return _context5.abrupt("return", Object.keys(intervalTree));
-
-              case 6:
-              case "end":
-                return _context5.stop();
-            }
-          }
-        }, _callee5, this);
-      }));
-
-      function getRefNames() {
-        return _getRefNames.apply(this, arguments);
-      }
-
-      return getRefNames;
-    }()
-  }, {
-    key: "getFeatures",
-    value: function getFeatures(region) {
-      var _this2 = this;
-
-      var opts = arguments.length > 1 && arguments[1] !== undefined ? arguments[1] : {};
-      return rxjs.ObservableCreate( /*#__PURE__*/function () {
-        var _ref = _asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee6(observer) {
-          var _intervalTree$refName, start, end, refName, _yield$_this2$setup, header, intervalTree, parser;
-
-          return runtime_1.wrap(function _callee6$(_context6) {
-            while (1) {
-              switch (_context6.prev = _context6.next) {
-                case 0:
-                  _context6.prev = 0;
-                  start = region.start, end = region.end, refName = region.refName;
-                  _context6.next = 4;
-                  return _this2.setup();
-
-                case 4:
-                  _yield$_this2$setup = _context6.sent;
-                  header = _yield$_this2$setup.header;
-                  intervalTree = _yield$_this2$setup.intervalTree;
-                  parser = new VCF__default({
-                    header: header
-                  });
-                  (_intervalTree$refName = intervalTree[refName]) === null || _intervalTree$refName === void 0 ? void 0 : _intervalTree$refName.search([start, end]).forEach(function (f) {
-                    return observer.next(new VCFFeature({
-                      variant: parser.parseLine(f.line),
-                      parser: parser,
-                      id: "".concat(_this2.id, "-").concat(f.id)
-                    }));
-                  });
-                  observer.complete();
-                  _context6.next = 15;
-                  break;
-
-                case 12:
-                  _context6.prev = 12;
-                  _context6.t0 = _context6["catch"](0);
-                  observer.error(_context6.t0);
-
-                case 15:
-                case "end":
-                  return _context6.stop();
-              }
-            }
-          }, _callee6, null, [[0, 12]]);
-        }));
-
-        return function (_x) {
-          return _ref.apply(this, arguments);
-        };
-      }(), opts.signal);
-    }
-  }, {
-    key: "freeResources",
-    value: function freeResources() {}
-  }]);
-
-  return VcfAdapter;
-}(BaseAdapter.BaseFeatureDataAdapter);
-VcfAdapter.capabilities = ['getFeatures', 'getRefNames'];
-
-var VcfAdapter$1 = {
-  __proto__: null,
-  'default': VcfAdapter
-};
-
-var useStyles = /*#__PURE__*/core.makeStyles(function (theme) {
-  return {
-    closeButton: {
-      position: 'absolute',
-      right: theme.spacing(1),
-      top: theme.spacing(1),
-      color: theme.palette.grey[500]
-    },
-    block: {
-      display: 'block'
-    }
-  };
-});
-
-function BreakendOptionDialog(_ref) {
-  var model = _ref.model,
-      handleClose = _ref.handleClose,
-      feature = _ref.feature,
-      viewType = _ref.viewType;
-  var classes = useStyles();
-
-  var _useState = React.useState(true),
-      _useState2 = _slicedToArray(_useState, 2),
-      copyTracks = _useState2[0],
-      setCopyTracks = _useState2[1];
-
-  var _useState3 = React.useState(true),
-      _useState4 = _slicedToArray(_useState3, 2),
-      mirrorTracks = _useState4[0],
-      setMirrorTracks = _useState4[1];
-
-  return /*#__PURE__*/React__default.createElement(core.Dialog, {
-    open: true,
-    onClose: handleClose
-  }, /*#__PURE__*/React__default.createElement(core.DialogTitle, null, "Breakpoint split view options", handleClose ? /*#__PURE__*/React__default.createElement(core.IconButton, {
-    className: classes.closeButton,
-    onClick: function onClick() {
-      return handleClose();
-    }
-  }, /*#__PURE__*/React__default.createElement(CloseIcon, null)) : null), /*#__PURE__*/React__default.createElement(core.Divider, null), /*#__PURE__*/React__default.createElement(core.DialogContent, null, /*#__PURE__*/React__default.createElement(core.FormControlLabel, {
-    className: classes.block,
-    control: /*#__PURE__*/React__default.createElement(core.Checkbox, {
-      checked: copyTracks,
-      onChange: function onChange() {
-        return setCopyTracks(function (val) {
-          return !val;
-        });
-      }
-    }),
-    label: "Copy tracks into the new view"
-  }), /*#__PURE__*/React__default.createElement(core.FormControlLabel, {
-    className: classes.block,
-    control: /*#__PURE__*/React__default.createElement(core.Checkbox, {
-      checked: mirrorTracks,
-      onChange: function onChange() {
-        return setMirrorTracks(function (val) {
-          return !val;
-        });
-      }
-    }),
-    label: "Mirror tracks vertically in vertically stacked view"
-  })), /*#__PURE__*/React__default.createElement(core.DialogActions, null, /*#__PURE__*/React__default.createElement(core.Button, {
-    onClick: function onClick() {
-      var view = model.view;
-      var session = util.getSession(model);
-
-      try {
-        var viewSnapshot = viewType.snapshotFromBreakendFeature(feature, view);
-        viewSnapshot.views[0].offsetPx -= view.width / 2 + 100;
-        viewSnapshot.views[1].offsetPx -= view.width / 2 + 100;
-        viewSnapshot.featureData = feature;
-        var viewTracks = mobxStateTree.getSnapshot(view.tracks);
-        viewSnapshot.views[0].tracks = viewTracks;
-        viewSnapshot.views[1].tracks = mirrorTracks ? viewTracks.slice().reverse() : viewTracks;
-        session.addView('BreakpointSplitView', viewSnapshot);
-      } catch (e) {
-        console.error(e);
-        session.notify("".concat(e));
-      }
-
-      handleClose();
-    },
-    variant: "contained",
-    color: "primary",
-    autoFocus: true
-  }, "OK"), /*#__PURE__*/React__default.createElement(core.Button, {
-    onClick: function onClick() {
-      return handleClose();
-    },
-    color: "secondary",
-    variant: "contained"
-  }, "Cancel")));
-}
-
-var BreakendOptionDialog$1 = /*#__PURE__*/mobxReact.observer(BreakendOptionDialog);
-
-var _excluded = ["samples"];
-
-function VariantSamples(props) {
-  var _useState = React.useState({}),
-      _useState2 = _slicedToArray(_useState, 2),
-      filter = _useState2[0],
-      setFilter = _useState2[1];
-
-  var _useState3 = React.useState(false),
-      _useState4 = _slicedToArray(_useState3, 2),
-      showFilters = _useState4[0],
-      setShowFilters = _useState4[1];
-
-  var feature = props.feature;
-  var _feature$samples = feature.samples,
-      samples = _feature$samples === void 0 ? {} : _feature$samples;
-  var preFilteredRows = Object.entries(samples);
-
-  if (!preFilteredRows.length) {
-    return null;
-  }
-
-  var infoFields = ['sample'].concat(_toConsumableArray(Object.keys(preFilteredRows[0][1]))).map(function (field) {
-    return {
-      field: field
-    };
-  });
-  var error;
-  var rows = [];
-  var filters = Object.keys(filter); // catch some error thrown from regex
-  // note: maps all values into a string, if this is not done rows are not
-  // sortable by the data-grid
-
-  try {
-    rows = preFilteredRows.map(function (row) {
-      return _objectSpread2(_objectSpread2({}, Object.fromEntries(Object.entries(row[1]).map(function (entry) {
-        return [entry[0], String(entry[1])];
-      }))), {}, {
-        sample: row[0],
-        id: row[0]
-      });
-    }).filter(function (row) {
-      return filters.length ? filters.every(function (key) {
-        var val = row[key];
-        var currFilter = filter[key];
-        return currFilter ? val.match(new RegExp(currFilter, 'i')) : true;
-      }) : true;
-    });
-  } catch (e) {
-    error = e;
-  } // disableSelectionOnClick helps avoid
-  // https://github.com/mui-org/material-ui-x/issues/1197
-
-
-  return /*#__PURE__*/React__default.createElement(BaseFeatureDetail.BaseCard, Object.assign({}, props, {
-    title: "Samples"
-  }), error ? /*#__PURE__*/React__default.createElement(core.Typography, {
-    color: "error"
-  }, "".concat(error)) : null, /*#__PURE__*/React__default.createElement(core.FormControlLabel, {
-    control: /*#__PURE__*/React__default.createElement(core.Checkbox, {
-      checked: showFilters,
-      onChange: function onChange() {
-        return setShowFilters(function (f) {
-          return !f;
-        });
-      }
-    }),
-    label: "Show sample filters"
-  }), showFilters ? /*#__PURE__*/React__default.createElement(React__default.Fragment, null, /*#__PURE__*/React__default.createElement(core.Typography, null, "These filters can use a plain text search or regex style query, e.g. in the genotype field, entering 1 will query for all genotypes that include the first alternate allele e.g. 0|1 or 1|1, entering [1-9]\\d* will find any non-zero allele e.g. 0|2 or 2/33"), infoFields.map(function (_ref) {
-    var field = _ref.field;
-    return /*#__PURE__*/React__default.createElement(core.TextField, {
-      key: "filter-".concat(field),
-      placeholder: "Filter ".concat(field),
-      value: filter[field] || '',
-      onChange: function onChange(event) {
-        return setFilter(_objectSpread2(_objectSpread2({}, filter), {}, _defineProperty({}, field, event.target.value)));
-      }
-    });
-  })) : null, /*#__PURE__*/React__default.createElement("div", {
-    style: {
-      height: 600,
-      width: '100%',
-      overflow: 'auto'
-    }
-  }, /*#__PURE__*/React__default.createElement(xDataGrid.DataGrid, {
-    rows: rows,
-    columns: infoFields,
-    rowHeight: 20,
-    headerHeight: 25,
-    disableSelectionOnClick: true,
-    disableColumnMenu: true
-  })));
-}
-
-function BreakendPanel(props) {
-  var model = props.model,
-      locStrings = props.locStrings,
-      feature = props.feature;
-  var session = util.getSession(model);
-
-  var _getEnv = mobxStateTree.getEnv(session),
-      pluginManager = _getEnv.pluginManager;
-
-  var _useState5 = React.useState(false),
-      _useState6 = _slicedToArray(_useState5, 2),
-      breakpointDialog = _useState6[0],
-      setBreakpointDialog = _useState6[1];
-
-  var viewType;
-
-  try {
-    viewType = pluginManager.getViewType('BreakpointSplitView');
-  } catch (e) {// ignore
-  }
-
-  var simpleFeature = new SimpleFeature(feature);
-  return /*#__PURE__*/React__default.createElement(BaseFeatureDetail.BaseCard, Object.assign({}, props, {
-    title: "Breakends"
-  }), /*#__PURE__*/React__default.createElement(core.Typography, null, "Link to linear view of breakend endpoints"), /*#__PURE__*/React__default.createElement("ul", null, locStrings.map(function (locString) {
-    return /*#__PURE__*/React__default.createElement("li", {
-      key: "".concat(JSON.stringify(locString))
-    }, /*#__PURE__*/React__default.createElement(core.Link, {
-      href: "#",
-      onClick: function onClick(event) {
-        event.preventDefault();
-        var view = model.view;
-
-        try {
-          if (view) {
-            var _view$navToLocString;
-
-            (_view$navToLocString = view.navToLocString) === null || _view$navToLocString === void 0 ? void 0 : _view$navToLocString.call(view, locString);
-          } else {
-            throw new Error('No view associated with this feature detail panel anymore');
-          }
-        } catch (e) {
-          console.error(e);
-          session.notify("".concat(e));
-        }
-      }
-    }, "LGV - ".concat(locString)));
-  })), viewType ? /*#__PURE__*/React__default.createElement("div", null, /*#__PURE__*/React__default.createElement(core.Typography, null, "Launch split views with breakend source and target"), /*#__PURE__*/React__default.createElement("ul", null, locStrings.map(function (locString) {
-    return /*#__PURE__*/React__default.createElement("li", {
-      key: "".concat(JSON.stringify(locString))
-    }, /*#__PURE__*/React__default.createElement(core.Link, {
-      href: "#",
-      onClick: function onClick(event) {
-        event.preventDefault();
-        setBreakpointDialog(true);
-      }
-    }, "".concat(feature.refName, ":").concat(feature.start, " // ").concat(locString, " (split view)")));
-  })), breakpointDialog ? /*#__PURE__*/React__default.createElement(BreakendOptionDialog$1, {
-    model: model,
-    feature: simpleFeature,
-    viewType: viewType,
-    handleClose: function handleClose() {
-      setBreakpointDialog(false);
-    }
-  }) : null) : null);
-}
-
-function VariantFeatureDetails(props) {
-  var model = props.model;
-  var featureData = model.featureData,
-      descriptions = model.descriptions;
-  var feat = JSON.parse(JSON.stringify(featureData));
-
-  var rest = _objectWithoutProperties(feat, _excluded);
-
-  var basicDescriptions = {
-    CHROM: 'chromosome: An identifier from the reference genome',
-    POS: 'position: The reference position, with the 1st base having position 1',
-    ID: 'identifier: Semi-colon separated list of unique identifiers where available',
-    REF: 'reference base(s): Each base must be one of A,C,G,T,N (case insensitive).',
-    ALT: 'alternate base(s): Comma-separated list of alternate non-reference alleles',
-    QUAL: 'quality: Phred-scaled quality score for the assertion made in ALT',
-    FILTER: 'filter status: PASS if this position has passed all filters, otherwise a semicolon-separated list of codes for filters that fail'
-  };
-  return /*#__PURE__*/React__default.createElement(core.Paper, {
-    "data-testid": "variant-side-drawer"
-  }, /*#__PURE__*/React__default.createElement(BaseFeatureDetail.FeatureDetails, Object.assign({
-    feature: rest,
-    descriptions: _objectSpread2(_objectSpread2({}, basicDescriptions), descriptions)
-  }, props)), /*#__PURE__*/React__default.createElement(core.Divider, null), feat.type === 'breakend' ? /*#__PURE__*/React__default.createElement(BreakendPanel, {
-    feature: feat,
-    locStrings: feat.ALT.map(function (alt) {
-      var _parseBreakend;
-
-      return ((_parseBreakend = VCF.parseBreakend(alt)) === null || _parseBreakend === void 0 ? void 0 : _parseBreakend.MatePosition) || '';
-    }),
-    model: model
-  }) : null, feat.type === 'translocation' ? /*#__PURE__*/React__default.createElement(BreakendPanel, {
-    feature: feat,
-    model: model,
-    locStrings: ["".concat(feat.INFO.CHR2[0], ":").concat(feat.INFO.END)]
-  }) : null, /*#__PURE__*/React__default.createElement(VariantSamples, Object.assign({
-    feature: feat
-  }, props)));
-}
-
-var VariantFeatureWidget = /*#__PURE__*/mobxReact.observer(VariantFeatureDetails);
-
-var VariantFeatureWidget$1 = {
-  __proto__: null,
-  'default': VariantFeatureWidget
-};
-
-exports.VcfFeature = VCFFeature;
-exports.default = VariantsPlugin;
-//# sourceMappingURL=plugin-variants.cjs.development.js.map