@erosolaraijs/cure 2.2.0 → 2.3.1

package/dist/capabilities/emergingTherapeutics.d.ts

@@ -0,0 +1,145 @@
+/**
+ * 新兴治疗技术框架 (Emerging Therapeutics Framework)
+ *
+ * ███████╗███╗   ███╗███████╗██████╗  ██████╗ ██╗███╗   ██╗ ██████╗
+ * ██╔════╝████╗ ████║██╔════╝██╔══██╗██╔════╝ ██║████╗  ██║██╔════╝
+ * █████╗  ██╔████╔██║█████╗  ██████╔╝██║  ███╗██║██╔██╗ ██║██║  ███╗
+ * ██╔══╝  ██║╚██╔╝██║██╔══╝  ██╔══██╗██║   ██║██║██║╚██╗██║██║   ██║
+ * ███████╗██║ ╚═╝ ██║███████╗██║  ██║╚██████╔╝██║██║ ╚████║╚██████╔╝
+ * ╚══════╝╚═╝     ╚═╝╚══════╝╚═╝  ╚═╝ ╚═════╝ ╚═╝╚═╝  ╚═══╝ ╚═════╝
+ *
+ * Cutting-edge cancer treatment technologies and novel targets:
+ * - 细胞治疗 (Cellular Therapies)
+ * - 靶向蛋白降解 (Targeted Protein Degradation)
+ * - 基因编辑 (Gene Editing)
+ * - 新型抗体技术 (Novel Antibody Technologies)
+ * - 纳米医学 (Nanomedicine)
+ * - 人工智能药物发现 (AI-Driven Drug Discovery)
+ */
+export interface EmergingTherapy {
+    id: string;
+    name: string;
+    category: 'cellular' | 'small_molecule' | 'antibody' | 'nucleic_acid' | 'gene_therapy' | 'radiation' | 'other';
+    mechanism: string;
+    targets: string[];
+    cancerTypes: string[];
+    developmentStage: 'preclinical' | 'phase_1' | 'phase_2' | 'phase_3' | 'approved' | 'breakthrough_therapy';
+    keyTrials: string[];
+    advantages: string[];
+    challenges: string[];
+    estimatedTimeline: string;
+    companies: string[];
+    references: string[];
+}
+export interface NovelTarget {
+    gene: string;
+    protein: string;
+    pathway: string;
+    targetType: 'oncogene' | 'tumor_suppressor' | 'synthetic_lethality' | 'immune' | 'metabolic' | 'epigenetic' | 'other';
+    druggability: 'high' | 'medium' | 'low' | 'undruggable_becoming_druggable';
+    cancerTypes: string[];
+    approachesInDevelopment: string[];
+    leadCompounds: {
+        name: string;
+        stage: string;
+        company: string;
+    }[];
+    rationale: string;
+    references: string[];
+}
+export interface NextGenCellularTherapy {
+    id: string;
+    name: string;
+    type: 'car_t' | 'car_nk' | 'til' | 'tcr_t' | 'car_m' | 'ipsc_derived' | 'gamma_delta' | 'nkt';
+    target: string;
+    generation: string;
+    modifications: string[];
+    cancerTypes: string[];
+    advantages: string[];
+    clinicalStatus: string;
+    keyTrials: string[];
+    manufacturers: string[];
+}
+export interface ProteinDegrader {
+    id: string;
+    name: string;
+    type: 'protac' | 'molecular_glue' | 'lysosome_targeting' | 'autophagy';
+    target: string;
+    e3Ligase: string;
+    linker: string;
+    cancerTypes: string[];
+    status: string;
+    advantages: string[];
+    company: string;
+    references: string[];
+}
+export interface RadiopharmaceuticalTherapy {
+    id: string;
+    name: string;
+    radioisotope: string;
+    halfLife: string;
+    emissionType: 'beta' | 'alpha' | 'auger';
+    targetingMoiety: string;
+    target: string;
+    cancerTypes: string[];
+    approvalStatus: string;
+    keyTrials: string[];
+    advantages: string[];
+    sideEffects: string[];
+}
+export interface AIDiscoveredDrug {
+    id: string;
+    name: string;
+    aiPlatform: string;
+    discoveryMethod: string;
+    target: string;
+    indication: string;
+    developmentStage: string;
+    company: string;
+    timeFromDiscoveryToClinic: string;
+    novelty: string;
+}
+export declare class EmergingTherapeuticsModule {
+    private nextGenCellular;
+    private proteinDegraders;
+    private radiopharmaceuticals;
+    private novelAntibodyTech;
+    private nucleicAcidTherapies;
+    private novelTargets;
+    private aiDiscoveredDrugs;
+    getNextGenCellularTherapies(type?: string): Promise<NextGenCellularTherapy[]>;
+    getProteinDegraders(targetType?: string): Promise<ProteinDegrader[]>;
+    getRadiopharmaceuticals(emissionType?: string): Promise<RadiopharmaceuticalTherapy[]>;
+    getNovelAntibodyTech(): Promise<EmergingTherapy[]>;
+    getNucleicAcidTherapies(): Promise<EmergingTherapy[]>;
+    getNovelTargets(druggability?: string): Promise<NovelTarget[]>;
+    getAIDiscoveredDrugs(): Promise<AIDiscoveredDrug[]>;
+    getAllEmergingTherapies(): Promise<{
+        cellularTherapies: NextGenCellularTherapy[];
+        proteinDegraders: ProteinDegrader[];
+        radiopharmaceuticals: RadiopharmaceuticalTherapy[];
+        novelAntibodies: EmergingTherapy[];
+        nucleicAcidTherapies: EmergingTherapy[];
+        novelTargets: NovelTarget[];
+        aiDiscoveredDrugs: AIDiscoveredDrug[];
+    }>;
+    searchEmergingTherapiesForCancer(cancerType: string): Promise<{
+        cellular: NextGenCellularTherapy[];
+        degraders: ProteinDegrader[];
+        radiopharmaceuticals: RadiopharmaceuticalTherapy[];
+        antibodies: EmergingTherapy[];
+        nucleicAcid: EmergingTherapy[];
+        targets: NovelTarget[];
+    }>;
+    getStatistics(): {
+        totalCellularTherapies: number;
+        totalProteinDegraders: number;
+        totalRadiopharmaceuticals: number;
+        totalNovelAntibodies: number;
+        totalNucleicAcid: number;
+        totalNovelTargets: number;
+        totalAIDrugs: number;
+        breakdownByStage: Record<string, number>;
+    };
+}
+//# sourceMappingURL=emergingTherapeutics.d.ts.map

package/dist/capabilities/emergingTherapeutics.d.ts.map

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