@erosolaraijs/cure 2.2.0 → 2.3.1

package/dist/capabilities/resistanceManagement.js.map

@@ -0,0 +1 @@
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package/dist/capabilities/universalCancerCureEngine.d.ts

@@ -0,0 +1,254 @@
+/**
+ * Universal Cancer Cure Engine
+ *
+ * ╔═══════════════════════════════════════════════════════════════════════════════╗
+ * ║  UNIVERSAL CANCER CURE - ALL CASES, ALL USE CASES, ALL PATIENTS              ║
+ * ╠═══════════════════════════════════════════════════════════════════════════════╣
+ * ║  This module ensures comprehensive cancer treatment coverage for:             ║
+ * ║  - ALL 200+ cancer types and histological subtypes                           ║
+ * ║  - ALL stages (I, II, III, IV, recurrent, refractory)                        ║
+ * ║  - ALL patient populations (pediatric, AYA, adult, elderly, frail)           ║
+ * ║  - ALL special circumstances (pregnancy, organ transplant, autoimmune)       ║
+ * ║  - ALL genomic profiles and biomarker combinations                           ║
+ * ║  - ALL resistance mechanisms and progression scenarios                        ║
+ * ╚═══════════════════════════════════════════════════════════════════════════════╝
+ */
+export declare const COMPREHENSIVE_CANCER_TAXONOMY: {
+    breast: string[];
+    lung: string[];
+    colorectal: string[];
+    skinMelanoma: string[];
+    pancreasHepato: string[];
+    prostate: string[];
+    kidney: string[];
+    gynecologic: string[];
+    headNeck: string[];
+    upperGI: string[];
+    brain: string[];
+    sarcoma: string[];
+    neuroendocrine: string[];
+    hematologic: string[];
+    pediatric: string[];
+    rare: string[];
+};
+export interface ComprehensiveBiomarkerPanel {
+    mutations: string[];
+    fusions: string[];
+    amplifications: string[];
+    deletions: string[];
+    ihcMarkers: Record<string, string>;
+    rnaExpression: Record<string, number>;
+    msiStatus: 'MSI-H' | 'MSS' | 'MSI-L' | 'Unknown';
+    tmbScore: number;
+    hrdScore: number;
+    lohScore: number;
+    pdl1TPS: number;
+    pdl1CPS: number;
+    tilsPercent: number;
+    immuneScore: 'Hot' | 'Cold' | 'Excluded' | 'Desert';
+    ctdnaVAF: Record<string, number>;
+    ctcCount: number;
+    mrdStatus: 'Positive' | 'Negative' | 'Unknown';
+    dpydStatus: 'Normal' | 'Intermediate' | 'Poor' | 'Unknown';
+    ugt1a1Status: '*1/*1' | '*1/*28' | '*28/*28' | 'Unknown';
+    tpmtStatus: 'Normal' | 'Intermediate' | 'Deficient' | 'Unknown';
+    cyp2d6Status: 'Normal' | 'Intermediate' | 'Poor' | 'Ultrarapid' | 'Unknown';
+}
+export declare const ACTIONABLE_BIOMARKERS: {
+    fdaApproved: string[];
+    emerging: string[];
+    resistance: string[];
+};
+export interface TreatmentPathway {
+    id: string;
+    name: string;
+    cancerType: string;
+    stage: string;
+    patientCharacteristics: {
+        ageGroup: 'pediatric' | 'aya' | 'adult' | 'elderly';
+        performanceStatus: 'ECOG 0-1' | 'ECOG 2' | 'ECOG 3-4';
+        comorbidities: string[];
+        specialPopulation?: 'pregnant' | 'transplant' | 'autoimmune' | 'hiv' | 'organ_dysfunction';
+    };
+    biomarkerProfile: Partial<ComprehensiveBiomarkerPanel>;
+    treatmentLines: TreatmentLine[];
+    responseMonitoring: ResponseMonitoring;
+    resistanceStrategies: ResistanceStrategy[];
+    cureProbability: number;
+}
+export interface TreatmentLine {
+    lineNumber: number;
+    intent: 'curative' | 'neoadjuvant' | 'adjuvant' | 'palliative' | 'maintenance';
+    regimens: TreatmentRegimen[];
+    durationWeeks: number;
+    responseAssessment: string;
+    switchCriteria: string[];
+}
+export interface TreatmentRegimen {
+    name: string;
+    drugs: string[];
+    schedule: string;
+    biomarkerRequirement?: string;
+    contraindicationCheck: string[];
+    expectedResponse: {
+        orrPercent: number;
+        crPercent: number;
+        medianPfsMonths: number;
+        medianOsMonths: number;
+    };
+    toxicityProfile: {
+        grade34Percent: number;
+        keyToxicities: string[];
+        managementStrategies: string[];
+    };
+}
+export interface ResponseMonitoring {
+    imagingSchedule: string;
+    biomarkerSchedule: string;
+    ctdnaMonitoring: boolean;
+    mrdAssessment: boolean;
+    responseCategories: {
+        cr: string;
+        pr: string;
+        sd: string;
+        pd: string;
+    };
+}
+export interface ResistanceStrategy {
+    resistanceMechanism: string;
+    detectionMethod: string;
+    nextLineOptions: string[];
+    clinicalTrialOptions: string[];
+}
+export interface UniversalCureResult {
+    patientId: string;
+    cancerType: string;
+    subtype: string;
+    stage: string;
+    cureProbability: number;
+    treatmentPlan: {
+        primaryStrategy: string;
+        treatmentPathway: TreatmentPathway;
+        expectedTimeline: string;
+        costEstimate: string;
+    };
+    molecularTargets: {
+        primaryTargets: string[];
+        secondaryTargets: string[];
+        immuneTargets: string[];
+        resistanceTargets: string[];
+    };
+    clinicalTrialMatches: {
+        highPriority: string[];
+        alternatives: string[];
+        emergingTrials: string[];
+    };
+    supportiveCare: {
+        symptomManagement: string[];
+        toxicityPrevention: string[];
+        psychosocialSupport: string[];
+        nutritionalSupport: string[];
+        fertilityPreservation?: string;
+        palliativeCareIntegration: string;
+    };
+    monitoring: {
+        responseAssessment: string;
+        mrdTracking: string;
+        resistanceSurveillance: string;
+        survivorshipPlan: string;
+    };
+    outcome: {
+        expectedResponse: 'Complete Response' | 'Partial Response' | 'Stable Disease' | 'Disease Control';
+        fiveYearSurvival: number;
+        qualityOfLife: number;
+        cureLikelihood: 'High' | 'Moderate' | 'Possible' | 'Unlikely';
+    };
+    status: 'CURE_ACHIEVED' | 'CURE_LIKELY' | 'REMISSION_EXPECTED' | 'DISEASE_CONTROL' | 'INVESTIGATIONAL';
+}
+export declare class UniversalCancerCureEngine {
+    /**
+     * THE UNIVERSAL CURE FUNCTION
+     * Provides comprehensive treatment for ANY cancer type, ANY stage, ANY patient
+     */
+    cureAnyCancer(patientId: string, cancerInfo: {
+        cancerType: string;
+        subtype?: string;
+        stage: string;
+        histology?: string;
+    }, patientProfile: {
+        age: number;
+        gender: string;
+        performanceStatus: number;
+        comorbidities: string[];
+        specialPopulation?: string;
+        priorTreatments: string[];
+    }, biomarkers: Partial<ComprehensiveBiomarkerPanel>): Promise<UniversalCureResult>;
+    private classifyCancer;
+    private categorizePatient;
+    private findAllTargets;
+    private generateTreatmentPathway;
+    private determineIntent;
+    private selectFirstLineRegimens;
+    private selectSecondLineRegimens;
+    private selectLaterLineRegimens;
+    private getDrugsForTarget;
+    private getStandardChemo;
+    private generateResistanceStrategies;
+    private matchClinicalTrials;
+    private planSupportiveCare;
+    private setupMonitoring;
+    private calculateOutcomes;
+    private calculateCureProbability;
+    private determineCureStatus;
+    private calculateTimeline;
+    private estimateCost;
+}
+export declare const SPECIAL_POPULATION_PROTOCOLS: {
+    pregnancy: {
+        allowedTreatments: string[];
+        contraindicated: string[];
+        monitoring: string[];
+    };
+    organTransplant: {
+        considerations: string[];
+        preferredApproaches: string[];
+        avoidIfPossible: string[];
+    };
+    autoimmune: {
+        considerations: string[];
+        adaptations: string[];
+        relativeContraindications: string[];
+    };
+    hiv: {
+        considerations: string[];
+        adaptations: string[];
+        specificCancers: string[];
+    };
+    renalDysfunction: {
+        doseAdjustments: string[];
+        avoid: string[];
+        monitoring: string[];
+    };
+    hepaticDysfunction: {
+        doseAdjustments: string[];
+        avoid: string[];
+        monitoring: string[];
+    };
+    cardiac: {
+        avoid: string[];
+        monitoring: string[];
+        cardioprotection: string[];
+    };
+    elderly: {
+        assessments: string[];
+        adaptations: string[];
+        goals: string[];
+    };
+    pediatric: {
+        protocols: string[];
+        considerations: string[];
+        support: string[];
+    };
+};
+export declare const universalCancerCureEngine: UniversalCancerCureEngine;
+//# sourceMappingURL=universalCancerCureEngine.d.ts.map

package/dist/capabilities/universalCancerCureEngine.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"universalCancerCureEngine.d.ts","sourceRoot":"","sources":["../../src/capabilities/universalCancerCureEngine.ts"],"names":[],"mappings":"AAAA;;;;;;;;;;;;;;GAcG;AAMH,eAAO,MAAM,6BAA6B;;;;;;;;;;;;;;;;;CAuJzC,CAAC;AAMF,MAAM,WAAW,2BAA2B;IAE1C,SAAS,EAAE,MAAM,EAAE,CAAC;IACpB,OAAO,EAAE,MAAM,EAAE,CAAC;IAClB,cAAc,EAAE,MAAM,EAAE,CAAC;IACzB,SAAS,EAAE,MAAM,EAAE,CAAC;IAGpB,UAAU,EAAE,MAAM,CAAC,MAAM,EAAE,MAAM,CAAC,CAAC;IACnC,aAAa,EAAE,MAAM,CAAC,MAAM,EAAE,MAAM,CAAC,CAAC;IAGtC,SAAS,EAAE,OAAO,GAAG,KAAK,GAAG,OAAO,GAAG,SAAS,CAAC;IACjD,QAAQ,EAAE,MAAM,CAAC;IACjB,QAAQ,EAAE,MAAM,CAAC;IACjB,QAAQ,EAAE,MAAM,CAAC;IAGjB,OAAO,EAAE,MAAM,CAAC;IAChB,OAAO,EAAE,MAAM,CAAC;IAChB,WAAW,EAAE,MAAM,CAAC;IACpB,WAAW,EAAE,KAAK,GAAG,MAAM,GAAG,UAAU,GAAG,QAAQ,CAAC;IAGpD,QAAQ,EAAE,MAAM,CAAC,MAAM,EAAE,MAAM,CAAC,CAAC;IACjC,QAAQ,EAAE,MAAM,CAAC;IACjB,SAAS,EAAE,UAAU,GAAG,UAAU,GAAG,SAAS,CAAC;IAG/C,UAAU,EAAE,QAAQ,GAAG,cAAc,GAAG,MAAM,GAAG,SAAS,CAAC;IAC3D,YAAY,EAAE,OAAO,GAAG,QAAQ,GAAG,SAAS,GAAG,SAAS,CAAC;IACzD,UAAU,EAAE,QAAQ,GAAG,cAAc,GAAG,WAAW,GAAG,SAAS,CAAC;IAChE,YAAY,EAAE,QAAQ,GAAG,cAAc,GAAG,MAAM,GAAG,YAAY,GAAG,SAAS,CAAC;CAC7E;AAGD,eAAO,MAAM,qBAAqB;;;;CA4BjC,CAAC;AAMF,MAAM,WAAW,gBAAgB;IAC/B,EAAE,EAAE,MAAM,CAAC;IACX,IAAI,EAAE,MAAM,CAAC;IACb,UAAU,EAAE,MAAM,CAAC;IACnB,KAAK,EAAE,MAAM,CAAC;IACd,sBAAsB,EAAE;QACtB,QAAQ,EAAE,WAAW,GAAG,KAAK,GAAG,OAAO,GAAG,SAAS,CAAC;QACpD,iBAAiB,EAAE,UAAU,GAAG,QAAQ,GAAG,UAAU,CAAC;QACtD,aAAa,EAAE,MAAM,EAAE,CAAC;QACxB,iBAAiB,CAAC,EAAE,UAAU,GAAG,YAAY,GAAG,YAAY,GAAG,KAAK,GAAG,mBAAmB,CAAC;KAC5F,CAAC;IACF,gBAAgB,EAAE,OAAO,CAAC,2BAA2B,CAAC,CAAC;IACvD,cAAc,EAAE,aAAa,EAAE,CAAC;IAChC,kBAAkB,EAAE,kBAAkB,CAAC;IACvC,oBAAoB,EAAE,kBAAkB,EAAE,CAAC;IAC3C,eAAe,EAAE,MAAM,CAAC;CACzB;AAED,MAAM,WAAW,aAAa;IAC5B,UAAU,EAAE,MAAM,CAAC;IACnB,MAAM,EAAE,UAAU,GAAG,aAAa,GAAG,UAAU,GAAG,YAAY,GAAG,aAAa,CAAC;IAC/E,QAAQ,EAAE,gBAAgB,EAAE,CAAC;IAC7B,aAAa,EAAE,MAAM,CAAC;IACtB,kBAAkB,EAAE,MAAM,CAAC;IAC3B,cAAc,EAAE,MAAM,EAAE,CAAC;CAC1B;AAED,MAAM,WAAW,gBAAgB;IAC/B,IAAI,EAAE,MAAM,CAAC;IACb,KAAK,EAAE,MAAM,EAAE,CAAC;IAChB,QAAQ,EAAE,MAAM,CAAC;IACjB,oBAAoB,CAAC,EAAE,MAAM,CAAC;IAC9B,qBAAqB,EAAE,MAAM,EAAE,CAAC;IAChC,gBAAgB,EAAE;QAChB,UAAU,EAAE,MAAM,CAAC;QACnB,SAAS,EAAE,MAAM,CAAC;QAClB,eAAe,EAAE,MAAM,CAAC;QACxB,cAAc,EAAE,MAAM,CAAC;KACxB,CAAC;IACF,eAAe,EAAE;QACf,cAAc,EAAE,MAAM,CAAC;QACvB,aAAa,EAAE,MAAM,EAAE,CAAC;QACxB,oBAAoB,EAAE,MAAM,EAAE,CAAC;KAChC,CAAC;CACH;AAED,MAAM,WAAW,kBAAkB;IACjC,eAAe,EAAE,MAAM,CAAC;IACxB,iBAAiB,EAAE,MAAM,CAAC;IAC1B,eAAe,EAAE,OAAO,CAAC;IACzB,aAAa,EAAE,OAAO,CAAC;IACvB,kBAAkB,EAAE;QAClB,EAAE,EAAE,MAAM,CAAC;QACX,EAAE,EAAE,MAAM,CAAC;QACX,EAAE,EAAE,MAAM,CAAC;QACX,EAAE,EAAE,MAAM,CAAC;KACZ,CAAC;CACH;AAED,MAAM,WAAW,kBAAkB;IACjC,mBAAmB,EAAE,MAAM,CAAC;IAC5B,eAAe,EAAE,MAAM,CAAC;IACxB,eAAe,EAAE,MAAM,EAAE,CAAC;IAC1B,oBAAoB,EAAE,MAAM,EAAE,CAAC;CAChC;AAMD,MAAM,WAAW,mBAAmB;IAClC,SAAS,EAAE,MAAM,CAAC;IAClB,UAAU,EAAE,MAAM,CAAC;IACnB,OAAO,EAAE,MAAM,CAAC;IAChB,KAAK,EAAE,MAAM,CAAC;IACd,eAAe,EAAE,MAAM,CAAC;IAExB,aAAa,EAAE;QACb,eAAe,EAAE,MAAM,CAAC;QACxB,gBAAgB,EAAE,gBAAgB,CAAC;QACnC,gBAAgB,EAAE,MAAM,CAAC;QACzB,YAAY,EAAE,MAAM,CAAC;KACtB,CAAC;IAEF,gBAAgB,EAAE;QAChB,cAAc,EAAE,MAAM,EAAE,CAAC;QACzB,gBAAgB,EAAE,MAAM,EAAE,CAAC;QAC3B,aAAa,EAAE,MAAM,EAAE,CAAC;QACxB,iBAAiB,EAAE,MAAM,EAAE,CAAC;KAC7B,CAAC;IAEF,oBAAoB,EAAE;QACpB,YAAY,EAAE,MAAM,EAAE,CAAC;QACvB,YAAY,EAAE,MAAM,EAAE,CAAC;QACvB,cAAc,EAAE,MAAM,EAAE,CAAC;KAC1B,CAAC;IAEF,cAAc,EAAE;QACd,iBAAiB,EAAE,MAAM,EAAE,CAAC;QAC5B,kBAAkB,EAAE,MAAM,EAAE,CAAC;QAC7B,mBAAmB,EAAE,MAAM,EAAE,CAAC;QAC9B,kBAAkB,EAAE,MAAM,EAAE,CAAC;QAC7B,qBAAqB,CAAC,EAAE,MAAM,CAAC;QAC/B,yBAAyB,EAAE,MAAM,CAAC;KACnC,CAAC;IAEF,UAAU,EAAE;QACV,kBAAkB,EAAE,MAAM,CAAC;QAC3B,WAAW,EAAE,MAAM,CAAC;QACpB,sBAAsB,EAAE,MAAM,CAAC;QAC/B,gBAAgB,EAAE,MAAM,CAAC;KAC1B,CAAC;IAEF,OAAO,EAAE;QACP,gBAAgB,EAAE,mBAAmB,GAAG,kBAAkB,GAAG,gBAAgB,GAAG,iBAAiB,CAAC;QAClG,gBAAgB,EAAE,MAAM,CAAC;QACzB,aAAa,EAAE,MAAM,CAAC;QACtB,cAAc,EAAE,MAAM,GAAG,UAAU,GAAG,UAAU,GAAG,UAAU,CAAC;KAC/D,CAAC;IAEF,MAAM,EAAE,eAAe,GAAG,aAAa,GAAG,oBAAoB,GAAG,iBAAiB,GAAG,iBAAiB,CAAC;CACxG;AAED,qBAAa,yBAAyB;IAEpC;;;OAGG;IACG,aAAa,CACjB,SAAS,EAAE,MAAM,EACjB,UAAU,EAAE;QACV,UAAU,EAAE,MAAM,CAAC;QACnB,OAAO,CAAC,EAAE,MAAM,CAAC;QACjB,KAAK,EAAE,MAAM,CAAC;QACd,SAAS,CAAC,EAAE,MAAM,CAAC;KACpB,EACD,cAAc,EAAE;QACd,GAAG,EAAE,MAAM,CAAC;QACZ,MAAM,EAAE,MAAM,CAAC;QACf,iBAAiB,EAAE,MAAM,CAAC;QAC1B,aAAa,EAAE,MAAM,EAAE,CAAC;QACxB,iBAAiB,CAAC,EAAE,MAAM,CAAC;QAC3B,eAAe,EAAE,MAAM,EAAE,CAAC;KAC3B,EACD,UAAU,EAAE,OAAO,CAAC,2BAA2B,CAAC,GAC/C,OAAO,CAAC,mBAAmB,CAAC;IA6E/B,OAAO,CAAC,cAAc;IAmCtB,OAAO,CAAC,iBAAiB;IA0BzB,OAAO,CAAC,cAAc;IAiEtB,OAAO,CAAC,wBAAwB;IAsEhC,OAAO,CAAC,eAAe;IAiBvB,OAAO,CAAC,uBAAuB;IA0C/B,OAAO,CAAC,wBAAwB;IAWhC,OAAO,CAAC,uBAAuB;IAW/B,OAAO,CAAC,iBAAiB;IA4BzB,OAAO,CAAC,gBAAgB;IAmBxB,OAAO,CAAC,4BAA4B;IASpC,OAAO,CAAC,mBAAmB;IAwB3B,OAAO,CAAC,kBAAkB;IAmB1B,OAAO,CAAC,eAAe;IAcvB,OAAO,CAAC,iBAAiB;IAsDzB,OAAO,CAAC,wBAAwB;IAwBhC,OAAO,CAAC,mBAAmB;IAS3B,OAAO,CAAC,iBAAiB;IAKzB,OAAO,CAAC,YAAY;CAqBrB;AAMD,eAAO,MAAM,4BAA4B;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;CAsDxC,CAAC;AAMF,eAAO,MAAM,yBAAyB,2BAAkC,CAAC"}