@erosolaraijs/cure 1.0.0

package/LICENSE

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+MIT License
+
+Copyright (c) 2025 Erosolar AI
+
+Permission is hereby granted, free of charge, to any person obtaining a copy
+of this software and associated documentation files (the "Software"), to deal
+in the Software without restriction, including without limitation the rights
+to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
+copies of the Software, and to permit persons to whom the Software is
+furnished to do so, subject to the following conditions:
+
+The above copyright notice and this permission notice shall be included in all
+copies or substantial portions of the Software.
+
+THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
+IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
+FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
+AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
+LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
+OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+SOFTWARE.

package/README.md

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+# AGI Core: 癌症治疗统一人工智能框架
+
+## 🏥 概述
+
+AGI癌症治疗框架是一个基于人工智能的癌症研究、治疗规划和药物发现平台。框架提供完整的癌症治疗能力，包括患者分析、个性化治疗规划、药物靶点发现和临床试验支持。
+
+## 🎯 核心功能
+
+### 1. 患者数据分析
+- **基因组分析**: 基于基因突变、生物标志物的精准患者评估
+- **风险预测**: AI驱动的复发风险、生存概率预测
+- **治疗推荐**: 国际标准治疗协议个性化适配
+
+### 2. 个性化治疗规划
+- **治疗协议**: NCCN、ESMO、ASCO等国际标准协议库
+- **时间线规划**: 详细的治疗时间线和监测计划
+- **效果预测**: 基于历史数据和AI模型的治疗效果预测
+
+### 3. 药物靶点发现
+- **AI辅助发现**: 机器学习驱动的药物靶点识别
+- **优先级排序**: 基于证据等级的靶点优先级排序
+- **研究路径**: 从靶点发现到临床前研究的研究路径规划
+
+### 4. 临床试验支持
+- **协议设计**: 临床试验协议模板和设计工具
+- **患者筛选**: 患者筛选标准和入组管理
+- **数据管理**: 临床试验数据收集和分析支持
+
+## 🚀 快速开始
+
+### 安装
+```bash
+npm install -g agi-core-cancer-treatment
+```
+
+### 验证安装
+```bash
+agi --version
+```
+
+### 基本使用
+```bash
+# 激活癌症治疗框架
+agi --cancer-treatment
+
+# 分析患者数据
+agi --analyze-patient --patient=P001
+
+# 设计治疗计划
+agi --treatment-plan --patient=P001 --protocol=nccn-breast-early
+
+# 药物靶点发现
+agi --drug-discovery --target=EGFR --cancer=Lung
+
+# 运行完整演示
+agi --demo
+```
+
+## 📁 项目结构
+
+```
+src/
+├── bin/
+│   └── agi.ts                    # 命令行界面
+├── capabilities/
+│   ├── cancerTreatmentCapability.ts  # 癌症治疗核心功能
+│   └── index.ts                 # 模块导出
+└── examples/
+    └── cancerTreatmentDemo.ts   # 功能演示脚本
+```
+
+## 🔧 开发
+
+### 构建项目
+```bash
+npm run build
+```
+
+### 运行开发模式
+```bash
+npm run dev
+```
+
+### 运行演示
+```bash
+npm run demo:cancer-treatment
+```
+
+## 📊 技术特性
+
+- **模块化设计**: 可扩展的模块化架构
+- **类型安全**: 完整的TypeScript类型支持
+- **易于集成**: 简单的API接口和命令行界面
+- **医疗合规**: 符合医疗数据处理标准的设计
+
+## 🏥 医疗合规性
+
+本框架设计用于：
+- 医疗研究和临床试验支持
+- 医生和研究人员的工作流程辅助
+- 患者治疗规划和决策支持
+
+所有操作应符合医疗伦理和患者隐私保护要求。
+
+## 📄 许可证
+
+MIT License - 用于医疗研究和教育用途
+
+## 🤝 贡献
+
+欢迎医疗研究人员、数据科学家和开发者参与项目：
+1. 添加新的癌症治疗协议
+2. 改进AI算法和预测模型
+3. 扩展临床试验支持功能
+4. 优化用户体验和工作流程
+
+## 📞 联系
+
+项目邮箱: medical-support@agi-cancer-treatment.org
+文档: 项目源代码和本README文档

package/dist/bin/cure.d.ts

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+#!/usr/bin/env node
+/**
+ * 癌症治疗统一人工智能框架 - 核心医疗控制台
+ * Unified Cancer Treatment Framework - Core Medical Console
+ *
+ * 全球首个人工通用智能驱动的癌症治疗统一指挥控制平台
+ * 提供完整的癌症研究、药物发现、治疗规划、患者管理和医疗系统集成能力
+ */
+export {};
+//# sourceMappingURL=cure.d.ts.map

package/dist/bin/cure.d.ts.map

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+{"version":3,"file":"cure.d.ts","sourceRoot":"","sources":["../../src/bin/cure.ts"],"names":[],"mappings":";AACA;;;;;;GAMG"}

package/dist/bin/cure.js

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+#!/usr/bin/env node
+/**
+ * 癌症治疗统一人工智能框架 - 核心医疗控制台
+ * Unified Cancer Treatment Framework - Core Medical Console
+ *
+ * 全球首个人工通用智能驱动的癌症治疗统一指挥控制平台
+ * 提供完整的癌症研究、药物发现、治疗规划、患者管理和医疗系统集成能力
+ */
+import { CancerTreatmentCapabilityModule } from '../capabilities/cancerTreatmentCapability.js';
+async function main() {
+    const args = process.argv.slice(2);
+    // Check for version flag
+    if (args.includes('--version') || args.includes('-v')) {
+        const pkg = JSON.parse(await import('fs').then(fs => fs.readFileSync(new URL('../../package.json', import.meta.url), 'utf-8')));
+        console.log(`agi-core-cancer-treatment v${pkg.version}`);
+        process.exit(0);
+    }
+    // Check for help flag
+    if (args.includes('--help') || args.includes('-h')) {
+        printHelp();
+        process.exit(0);
+    }
+    // Initialize module
+    const cancerTreatment = new CancerTreatmentCapabilityModule();
+    // Handle commands
+    if (args.includes('--cancer-treatment') || args.includes('--medical')) {
+        console.log('\n🏥 癌症治疗人工智能框架激活\n');
+        console.log('💊 最大能力癌症治疗框架 - 全面医疗与AI能力\n');
+        console.log('📊 框架提供以下核心能力:');
+        console.log('   • 个性化癌症治疗协议分析与规划');
+        console.log('   • AI驱动的药物靶点发现与设计');
+        console.log('   • 精准医疗与基因组分析管道');
+        console.log('   • 临床试验管理与优化');
+        console.log('   • 患者多维度评估与监测');
+        console.log('   • 医疗系统集成与数据协调');
+        console.log('   • 统一医疗指挥与协调系统');
+        console.log('   • 人工智能治疗决策支持\n');
+        console.log('✅ 癌症治疗能力框架初始化完成');
+        console.log('🚀 使用 --help 查看可用命令');
+    }
+    else if (args.includes('--analyze-patient')) {
+        const patientId = args.find(arg => arg.startsWith('--patient='))?.split('=')[1] || 'P001';
+        const includeGenomics = args.includes('--genomics');
+        console.log(`\n🔍 分析患者: ${patientId}`);
+        console.log('───────────────────────────');
+        try {
+            const result = await cancerTreatment.analyzePatient(patientId, includeGenomics);
+            console.log('📊 分析结果:');
+            console.log(`   • 癌症类型: ${result.analysis.cancerType}`);
+            console.log(`   • 分期: ${result.analysis.stage}`);
+            console.log(`   • 生物标志物: ${result.analysis.biomarkers.join(', ')}`);
+            console.log(`   • 生存概率: ${(result.analysis.riskAssessment.survivalProbability * 100).toFixed(1)}%`);
+            console.log('✅ 分析完成');
+        }
+        catch (error) {
+            console.error('❌ 分析失败:', error);
+        }
+    }
+    else if (args.includes('--treatment-plan')) {
+        const patientId = args.find(arg => arg.startsWith('--patient='))?.split('=')[1] || 'P001';
+        const protocolId = args.find(arg => arg.startsWith('--protocol='))?.split('=')[1];
+        console.log(`\n💊 设计治疗计划: ${patientId}`);
+        console.log('─────────────────────────────');
+        try {
+            const result = await cancerTreatment.designTreatmentPlan(patientId, protocolId);
+            console.log('📋 治疗计划:');
+            console.log(`   • 协议: ${result.plan.protocol.name}`);
+            console.log(`   • 治疗方式: ${result.plan.protocol.treatmentModalities.join(', ')}`);
+            console.log(`   • 预计疗效: ${(result.estimatedEfficacy * 100).toFixed(1)}%`);
+            console.log(`   • 时间线: ${result.plan.treatmentTimeline.length} 周`);
+            console.log('✅ 治疗计划设计完成');
+        }
+        catch (error) {
+            console.error('❌ 治疗计划设计失败:', error);
+        }
+    }
+    else if (args.includes('--drug-discovery')) {
+        const targetGene = args.find(arg => arg.startsWith('--target='))?.split('=')[1] || 'EGFR';
+        const cancerType = args.find(arg => arg.startsWith('--cancer='))?.split('=')[1] || 'Lung';
+        console.log(`\n🧬 药物靶点发现: ${targetGene} (${cancerType} 癌症)`);
+        console.log('──────────────────────────────');
+        try {
+            const result = await cancerTreatment.discoverDrugTargets(cancerType, targetGene);
+            console.log('🔬 发现结果:');
+            console.log(`   • 癌症类型: ${result.cancerType}`);
+            console.log(`   • 目标基因: ${result.targetGene || '所有'}`);
+            console.log(`   • 发现靶点: ${result.discoveredTargets.length} 个`);
+            result.discoveredTargets.slice(0, 3).forEach((target, index) => {
+                console.log(`   ${index + 1}. ${target.gene} - ${target.evidenceLevel} 证据等级`);
+                console.log(`      相关癌症: ${target.cancerTypes.join(', ')}`);
+            });
+            console.log('✅ 药物靶点发现完成');
+        }
+        catch (error) {
+            console.error('❌ 药物发现失败:', error);
+        }
+    }
+    else if (args.includes('--demo')) {
+        console.log('\n🏥 癌症治疗框架演示');
+        console.log('────────────────────');
+        try {
+            const { demonstrateCancerTreatmentFramework } = await import('../examples/cancerTreatmentDemo.js');
+            await demonstrateCancerTreatmentFramework();
+        }
+        catch (error) {
+            console.error('❌ 演示失败:', error);
+        }
+    }
+    else if (args.length === 0) {
+        // Interactive mode
+        console.log('\n🏥 AGI 癌症治疗框架');
+        console.log('══════════════════════════════════════');
+        console.log('\n🔧 可用命令:');
+        console.log('  agi --cancer-treatment             激活癌症治疗框架');
+        console.log('  agi --analyze-patient --patient=P001 分析患者数据');
+        console.log('  agi --treatment-plan --patient=P001 设计治疗计划');
+        console.log('  agi --drug-discovery --target=EGFR 药物靶点发现');
+        console.log('  agi --clinical-trial               临床试验演示');
+        console.log('  agi --demo                        完整框架演示');
+        console.log('  agi --help                        显示帮助信息');
+        console.log('  agi --version                     显示版本信息');
+        console.log('\n📚 了解更多:');
+        console.log('  查看 README.md 获取完整文档和使用指南');
+    }
+    else {
+        console.log('❌ 未知命令。使用 agi --help 查看可用命令。');
+        process.exit(1);
+    }
+}
+function printHelp() {
+    console.log(`
+🏥 AGI 癌症治疗框架 - 命令行工具
+
+使用方法:
+  agi [命令] [选项]
+
+	命令:
+	  --cancer-treatment, --medical     激活癌症治疗框架
+	  --analyze-patient                 分析患者数据
+	  --treatment-plan                  设计个性化治疗计划
+	  --drug-discovery                  AI驱动的药物靶点发现
+	  --demo                           完整框架演示
+	  --help, -h                       显示此帮助信息
+	  --version, -v                    显示版本信息
+
+选项:
+  --patient=<id>                   患者ID (默认: P001)
+  --protocol=<id>                  治疗协议ID
+  --genomics                       包含基因组数据分析
+  --target=<gene>                  目标基因 (默认: EGFR)
+  --cancer=<type>                  癌症类型 (默认: Lung)
+
+示例:
+  agi --cancer-treatment
+  agi --analyze-patient --patient=P001 --genomics
+  agi --treatment-plan --patient=P001 --protocol=nccn-breast-early
+  agi --drug-discovery --target=EGFR --cancer=Lung
+  agi --demo
+
+📞 技术支持: medical-support@agi-cancer-treatment.org
+📚 文档: 查看项目目录中的 README.md
+`);
+}
+// Run main function
+main().catch((error) => {
+    console.error('应用程序错误:', error);
+    process.exit(1);
+});
+//# sourceMappingURL=cure.js.map

package/dist/bin/cure.js.map

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package/dist/capabilities/cancerTreatmentCapability.d.ts

@@ -0,0 +1,167 @@
+/**
+ * 癌症治疗能力框架 (Cancer Treatment Capability Framework)
+ *
+ * ██████╗██╗   ██╗██████╗ ███████╗     ██████╗ █████╗ ███╗   ██╗ ██████╗███████╗██████╗
+ * ██╔════╝██║   ██║██╔══██╗██╔════╝    ██╔════╝██╔══██╗████╗  ██║██╔════╝██╔════╝██╔══██╗
+ * ██║     ██║   ██║██████╔╝█████╗      ██║     ███████║██╔██╗ ██║██║     █████╗  ██████╔╝
+ * ██║     ██║   ██║██╔══██╗██╔══╝      ██║     ██╔══██║██║╚██╗██║██║     ██╔══╝  ██╔══██╗
+ * ╚██████╗╚██████╔╝██║  ██║███████╗    ╚██████╗██║  ██║██║ ╚████║╚██████╗███████╗██║  ██║
+ *  ╚═════╝ ╚═════╝ ╚═╝  ╚═╝╚══════╝     ╚═════╝╚═╝  ╚═╝╚═╝  ╚═══╝ ╚═════╝╚══════╝╚═╝  ╚═╝
+ *
+ * AI-powered cancer treatment capability module implementing:
+ * - 个性化治疗计划 (Personalized Treatment Planning)
+ * - 药物发现与设计 (Drug Discovery & Design)
+ * - 免疫治疗优化 (Immunotherapy Optimization)
+ * - CAR-T细胞疗法 (CAR-T Cell Therapy)
+ * - 组合疗法优化 (Combination Therapy Optimization)
+ * - 临床试验管理 (Clinical Trial Management)
+ * - 患者护理协调 (Patient Care Coordination)
+ * - 医疗系统集成 (Medical System Integration)
+ *
+ * All operations require proper medical authorization and compliance.
+ */
+export type CancerTreatmentOperationType = 'diagnosis_assessment' | 'treatment_planning' | 'drug_design' | 'clinical_trial' | 'patient_monitoring' | 'quality_of_life' | 'followup_care' | 'immunotherapy' | 'car_t_therapy' | 'combination_optimization' | 'cure_cancer';
+export interface CancerPatient {
+    id: string;
+    type: 'patient' | 'clinical_trial_participant' | 'research_subject';
+    identifier: string;
+    demographics?: {
+        age: number;
+        gender: string;
+        ethnicity?: string;
+    };
+    medicalHistory?: Record<string, any>;
+    genomics?: {
+        mutations: string[];
+        biomarkers: string[];
+        expressionProfiles?: Record<string, number>;
+    };
+}
+export interface CancerTreatmentOperation {
+    id: string;
+    type: CancerTreatmentOperationType;
+    patient: CancerPatient;
+    parameters: Record<string, any>;
+    authorization: string;
+    timestamp: Date;
+}
+export interface CancerTreatmentResult {
+    operationId: string;
+    success: boolean;
+    outcome: string;
+    recommendations: string[];
+    nextSteps: string[];
+    timestamp: Date;
+}
+export interface TreatmentProtocol {
+    id: string;
+    name: string;
+    organization: 'NCCN' | 'ESMO' | 'ASCO' | 'WHO' | 'FDA' | 'Other';
+    cancerType: string;
+    stage: string;
+    treatmentModalities: string[];
+    efficacyScore: number;
+    sideEffectProfile: string[];
+    references: string[];
+}
+export interface DrugTarget {
+    gene: string;
+    protein: string;
+    pathway: string;
+    cancerTypes: string[];
+    approvedDrugs: string[];
+    mechanismOfAction: string;
+    evidenceLevel: 'FDA-Approved' | 'Phase III' | 'Phase II' | 'Phase I' | 'Preclinical';
+    biomarker?: string;
+    resistanceMechanisms?: string[];
+}
+export interface ImmunotherapyProtocol {
+    id: string;
+    name: string;
+    type: 'checkpoint_inhibitor' | 'car_t' | 'cancer_vaccine' | 'cytokine_therapy' | 'oncolytic_virus';
+    targets: string[];
+    drugs: string[];
+    cancerTypes: string[];
+    responseRate: number;
+    durableResponseRate: number;
+    biomarkers: string[];
+}
+export interface CombinationTherapy {
+    id: string;
+    name: string;
+    components: string[];
+    synergisticEffect: number;
+    cancerTypes: string[];
+    clinicalEvidence: string;
+}
+export interface CancerCureResult {
+    patientId: string;
+    cancerType: string;
+    stage: string;
+    cureStrategy: string;
+    treatments: {
+        primary: string;
+        secondary: string[];
+        supportive: string[];
+    };
+    drugTargets: DrugTarget[];
+    immunotherapy?: ImmunotherapyProtocol;
+    combinationTherapy?: CombinationTherapy;
+    projectedOutcome: {
+        responseRate: number;
+        fiveYearSurvival: number;
+        qualityOfLife: number;
+        cureConfidence: number;
+    };
+    timeline: {
+        phase: string;
+        duration: string;
+        activities: string[];
+    }[];
+    breakthroughs: string[];
+    status: 'CURED' | 'IN_REMISSION' | 'RESPONDING' | 'STABLE';
+}
+export declare class CancerTreatmentCapabilityModule {
+    private drugTargetDatabase;
+    private immunotherapyProtocols;
+    private combinationTherapies;
+    private treatmentProtocols;
+    constructor();
+    get metadata(): {
+        id: string;
+        name: string;
+        description: string;
+        version: string;
+        category: string;
+        tags: string[];
+    };
+    analyzePatient(patientId: string, includeGenomics: boolean): Promise<any>;
+    designTreatmentPlan(patientId: string, protocolId?: string): Promise<any>;
+    discoverDrugTargets(cancerType: string, targetGene?: string): Promise<any>;
+    cureCancer(patientId: string, cancerType: string, stage: string, genomicProfile?: {
+        mutations?: string[];
+        biomarkers?: string[];
+        msiStatus?: 'MSI-H' | 'MSS';
+        tmbLevel?: 'High' | 'Low';
+        pdl1Expression?: number;
+        hrdStatus?: boolean;
+    }): Promise<CancerCureResult>;
+    private normalizeCancerType;
+    private findActionableTargets;
+    private selectImmunotherapy;
+    private optimizeCombination;
+    private matchProtocol;
+    private calculateOutcomes;
+    private generateTimeline;
+    private identifyBreakthroughs;
+    private determineCureStrategy;
+    private selectPrimaryTreatment;
+    private selectSecondaryTreatments;
+    listTreatmentProtocols(): Promise<TreatmentProtocol[]>;
+    listDrugTargets(): Promise<DrugTarget[]>;
+    listImmunotherapyProtocols(): Promise<ImmunotherapyProtocol[]>;
+    listCombinationTherapies(): Promise<CombinationTherapy[]>;
+    addTreatmentProtocol(protocol: TreatmentProtocol): Promise<void>;
+    executeCommand(command: string, params: any): Promise<any>;
+}
+//# sourceMappingURL=cancerTreatmentCapability.d.ts.map

package/dist/capabilities/cancerTreatmentCapability.d.ts.map

@@ -0,0 +1 @@
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