@bgicli/bgicli 2.1.1 → 2.2.0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/data/skills/aav-vector-design-agent/SKILL.md +198 -0
- package/data/skills/adaptyv/SKILL.md +112 -0
- package/data/skills/adhd-daily-planner/SKILL.md +271 -0
- package/data/skills/aeon/SKILL.md +372 -0
- package/data/skills/agent-browser/SKILL.md +159 -0
- package/data/skills/agentd-drug-discovery/SKILL.md +52 -0
- package/data/skills/ai-analyzer/SKILL.md +218 -0
- package/data/skills/alphafold/SKILL.md +183 -0
- package/data/skills/alphafold-database/SKILL.md +500 -0
- package/data/skills/anndata/SKILL.md +394 -0
- package/data/skills/antibody-design-agent/SKILL.md +64 -0
- package/data/skills/arboreto/SKILL.md +237 -0
- package/data/skills/armored-cart-design-agent/SKILL.md +225 -0
- package/data/skills/arxiv-search/SKILL.md +224 -0
- package/data/skills/autonomous-oncology-agent/SKILL.md +77 -0
- package/data/skills/bayesian-optimizer/SKILL.md +60 -0
- package/data/skills/benchling-integration/SKILL.md +473 -0
- package/data/skills/bgpt-paper-search/SKILL.md +81 -0
- package/data/skills/bindcraft/SKILL.md +198 -0
- package/data/skills/binder-design/SKILL.md +182 -0
- package/data/skills/binding-characterization/SKILL.md +234 -0
- package/data/skills/bindingdb-database/SKILL.md +332 -0
- package/data/skills/bio-admet-prediction/SKILL.md +224 -0
- package/data/skills/bio-alignment-files-bam-statistics/SKILL.md +340 -0
- package/data/skills/bio-alignment-filtering/SKILL.md +322 -0
- package/data/skills/bio-alignment-indexing/SKILL.md +249 -0
- package/data/skills/bio-alignment-io/SKILL.md +301 -0
- package/data/skills/bio-alignment-msa-parsing/SKILL.md +366 -0
- package/data/skills/bio-alignment-msa-statistics/SKILL.md +375 -0
- package/data/skills/bio-alignment-pairwise/SKILL.md +277 -0
- package/data/skills/bio-alignment-sorting/SKILL.md +296 -0
- package/data/skills/bio-alignment-validation/SKILL.md +374 -0
- package/data/skills/bio-atac-seq-atac-peak-calling/SKILL.md +221 -0
- package/data/skills/bio-atac-seq-atac-qc/SKILL.md +292 -0
- package/data/skills/bio-atac-seq-differential-accessibility/SKILL.md +268 -0
- package/data/skills/bio-atac-seq-footprinting/SKILL.md +256 -0
- package/data/skills/bio-atac-seq-motif-deviation/SKILL.md +319 -0
- package/data/skills/bio-atac-seq-nucleosome-positioning/SKILL.md +321 -0
- package/data/skills/bio-basecalling/SKILL.md +368 -0
- package/data/skills/bio-batch-downloads/SKILL.md +384 -0
- package/data/skills/bio-batch-processing/SKILL.md +303 -0
- package/data/skills/bio-bedgraph-handling/SKILL.md +336 -0
- package/data/skills/bio-blast-searches/SKILL.md +354 -0
- package/data/skills/bio-causal-genomics-colocalization-analysis/SKILL.md +264 -0
- package/data/skills/bio-causal-genomics-fine-mapping/SKILL.md +267 -0
- package/data/skills/bio-causal-genomics-mediation-analysis/SKILL.md +264 -0
- package/data/skills/bio-causal-genomics-mendelian-randomization/SKILL.md +221 -0
- package/data/skills/bio-causal-genomics-pleiotropy-detection/SKILL.md +292 -0
- package/data/skills/bio-cfdna-preprocessing/SKILL.md +200 -0
- package/data/skills/bio-chipseq-differential-binding/SKILL.md +262 -0
- package/data/skills/bio-chipseq-motif-analysis/SKILL.md +387 -0
- package/data/skills/bio-chipseq-peak-annotation/SKILL.md +239 -0
- package/data/skills/bio-chipseq-peak-calling/SKILL.md +277 -0
- package/data/skills/bio-chipseq-qc/SKILL.md +391 -0
- package/data/skills/bio-chipseq-super-enhancers/SKILL.md +288 -0
- package/data/skills/bio-chipseq-visualization/SKILL.md +289 -0
- package/data/skills/bio-clinical-databases-clinvar-lookup/SKILL.md +188 -0
- package/data/skills/bio-clinical-databases-dbsnp-queries/SKILL.md +171 -0
- package/data/skills/bio-clinical-databases-gnomad-frequencies/SKILL.md +205 -0
- package/data/skills/bio-clinical-databases-hla-typing/SKILL.md +248 -0
- package/data/skills/bio-clinical-databases-myvariant-queries/SKILL.md +174 -0
- package/data/skills/bio-clinical-databases-pharmacogenomics/SKILL.md +232 -0
- package/data/skills/bio-clinical-databases-polygenic-risk/SKILL.md +276 -0
- package/data/skills/bio-clinical-databases-somatic-signatures/SKILL.md +261 -0
- package/data/skills/bio-clinical-databases-tumor-mutational-burden/SKILL.md +301 -0
- package/data/skills/bio-clinical-databases-variant-prioritization/SKILL.md +225 -0
- package/data/skills/bio-clip-seq-binding-site-annotation/SKILL.md +66 -0
- package/data/skills/bio-clip-seq-clip-alignment/SKILL.md +70 -0
- package/data/skills/bio-clip-seq-clip-motif-analysis/SKILL.md +62 -0
- package/data/skills/bio-clip-seq-clip-peak-calling/SKILL.md +282 -0
- package/data/skills/bio-clip-seq-clip-preprocessing/SKILL.md +142 -0
- package/data/skills/bio-codon-usage/SKILL.md +353 -0
- package/data/skills/bio-comparative-genomics-ancestral-reconstruction/SKILL.md +312 -0
- package/data/skills/bio-comparative-genomics-hgt-detection/SKILL.md +341 -0
- package/data/skills/bio-comparative-genomics-ortholog-inference/SKILL.md +308 -0
- package/data/skills/bio-comparative-genomics-positive-selection/SKILL.md +354 -0
- package/data/skills/bio-comparative-genomics-synteny-analysis/SKILL.md +315 -0
- package/data/skills/bio-compressed-files/SKILL.md +263 -0
- package/data/skills/bio-consensus-sequences/SKILL.md +340 -0
- package/data/skills/bio-copy-number-cnv-annotation/SKILL.md +307 -0
- package/data/skills/bio-copy-number-cnv-visualization/SKILL.md +294 -0
- package/data/skills/bio-copy-number-cnvkit-analysis/SKILL.md +290 -0
- package/data/skills/bio-copy-number-gatk-cnv/SKILL.md +270 -0
- package/data/skills/bio-crispr-screens-base-editing-analysis/SKILL.md +110 -0
- package/data/skills/bio-crispr-screens-batch-correction/SKILL.md +316 -0
- package/data/skills/bio-crispr-screens-crispresso-editing/SKILL.md +205 -0
- package/data/skills/bio-crispr-screens-hit-calling/SKILL.md +264 -0
- package/data/skills/bio-crispr-screens-jacks-analysis/SKILL.md +313 -0
- package/data/skills/bio-crispr-screens-library-design/SKILL.md +417 -0
- package/data/skills/bio-crispr-screens-mageck-analysis/SKILL.md +222 -0
- package/data/skills/bio-crispr-screens-screen-qc/SKILL.md +243 -0
- package/data/skills/bio-ctdna-mutation-detection/SKILL.md +234 -0
- package/data/skills/bio-data-visualization-circos-plots/SKILL.md +405 -0
- package/data/skills/bio-data-visualization-color-palettes/SKILL.md +244 -0
- package/data/skills/bio-data-visualization-genome-browser-tracks/SKILL.md +328 -0
- package/data/skills/bio-data-visualization-genome-tracks/SKILL.md +249 -0
- package/data/skills/bio-data-visualization-ggplot2-fundamentals/SKILL.md +313 -0
- package/data/skills/bio-data-visualization-heatmaps-clustering/SKILL.md +227 -0
- package/data/skills/bio-data-visualization-interactive-visualization/SKILL.md +210 -0
- package/data/skills/bio-data-visualization-multipanel-figures/SKILL.md +274 -0
- package/data/skills/bio-data-visualization-specialized-omics-plots/SKILL.md +251 -0
- package/data/skills/bio-data-visualization-upset-plots/SKILL.md +228 -0
- package/data/skills/bio-data-visualization-volcano-customization/SKILL.md +233 -0
- package/data/skills/bio-de-deseq2-basics/SKILL.md +376 -0
- package/data/skills/bio-de-edger-basics/SKILL.md +418 -0
- package/data/skills/bio-de-results/SKILL.md +378 -0
- package/data/skills/bio-de-visualization/SKILL.md +408 -0
- package/data/skills/bio-differential-expression-batch-correction/SKILL.md +253 -0
- package/data/skills/bio-differential-expression-timeseries-de/SKILL.md +370 -0
- package/data/skills/bio-differential-splicing/SKILL.md +177 -0
- package/data/skills/bio-duplicate-handling/SKILL.md +292 -0
- package/data/skills/bio-entrez-fetch/SKILL.md +334 -0
- package/data/skills/bio-entrez-link/SKILL.md +325 -0
- package/data/skills/bio-entrez-search/SKILL.md +311 -0
- package/data/skills/bio-epidemiological-genomics-amr-surveillance/SKILL.md +233 -0
- package/data/skills/bio-epidemiological-genomics-pathogen-typing/SKILL.md +202 -0
- package/data/skills/bio-epidemiological-genomics-phylodynamics/SKILL.md +207 -0
- package/data/skills/bio-epidemiological-genomics-transmission-inference/SKILL.md +237 -0
- package/data/skills/bio-epidemiological-genomics-variant-surveillance/SKILL.md +237 -0
- package/data/skills/bio-epitranscriptomics-m6a-differential/SKILL.md +88 -0
- package/data/skills/bio-epitranscriptomics-m6a-peak-calling/SKILL.md +89 -0
- package/data/skills/bio-epitranscriptomics-m6anet-analysis/SKILL.md +101 -0
- package/data/skills/bio-epitranscriptomics-merip-preprocessing/SKILL.md +81 -0
- package/data/skills/bio-epitranscriptomics-modification-visualization/SKILL.md +98 -0
- package/data/skills/bio-experimental-design-batch-design/SKILL.md +110 -0
- package/data/skills/bio-experimental-design-multiple-testing/SKILL.md +98 -0
- package/data/skills/bio-experimental-design-power-analysis/SKILL.md +84 -0
- package/data/skills/bio-experimental-design-sample-size/SKILL.md +93 -0
- package/data/skills/bio-expression-matrix-counts-ingest/SKILL.md +220 -0
- package/data/skills/bio-expression-matrix-gene-id-mapping/SKILL.md +256 -0
- package/data/skills/bio-expression-matrix-metadata-joins/SKILL.md +271 -0
- package/data/skills/bio-expression-matrix-sparse-handling/SKILL.md +247 -0
- package/data/skills/bio-fastq-quality/SKILL.md +279 -0
- package/data/skills/bio-filter-sequences/SKILL.md +265 -0
- package/data/skills/bio-flow-cytometry-bead-normalization/SKILL.md +315 -0
- package/data/skills/bio-flow-cytometry-clustering-phenotyping/SKILL.md +237 -0
- package/data/skills/bio-flow-cytometry-compensation-transformation/SKILL.md +196 -0
- package/data/skills/bio-flow-cytometry-cytometry-qc/SKILL.md +382 -0
- package/data/skills/bio-flow-cytometry-differential-analysis/SKILL.md +217 -0
- package/data/skills/bio-flow-cytometry-doublet-detection/SKILL.md +288 -0
- package/data/skills/bio-flow-cytometry-fcs-handling/SKILL.md +221 -0
- package/data/skills/bio-flow-cytometry-gating-analysis/SKILL.md +193 -0
- package/data/skills/bio-format-conversion/SKILL.md +193 -0
- package/data/skills/bio-fragment-analysis/SKILL.md +214 -0
- package/data/skills/bio-gatk-variant-calling/SKILL.md +422 -0
- package/data/skills/bio-genome-assembly-assembly-polishing/SKILL.md +333 -0
- package/data/skills/bio-genome-assembly-assembly-qc/SKILL.md +344 -0
- package/data/skills/bio-genome-assembly-contamination-detection/SKILL.md +235 -0
- package/data/skills/bio-genome-assembly-hifi-assembly/SKILL.md +178 -0
- package/data/skills/bio-genome-assembly-long-read-assembly/SKILL.md +307 -0
- package/data/skills/bio-genome-assembly-metagenome-assembly/SKILL.md +227 -0
- package/data/skills/bio-genome-assembly-scaffolding/SKILL.md +204 -0
- package/data/skills/bio-genome-assembly-short-read-assembly/SKILL.md +319 -0
- package/data/skills/bio-genome-engineering-base-editing-design/SKILL.md +277 -0
- package/data/skills/bio-genome-engineering-grna-design/SKILL.md +221 -0
- package/data/skills/bio-genome-engineering-hdr-template-design/SKILL.md +264 -0
- package/data/skills/bio-genome-engineering-off-target-prediction/SKILL.md +232 -0
- package/data/skills/bio-genome-engineering-prime-editing-design/SKILL.md +275 -0
- package/data/skills/bio-genome-intervals-bed-file-basics/SKILL.md +357 -0
- package/data/skills/bio-genome-intervals-bigwig-tracks/SKILL.md +351 -0
- package/data/skills/bio-genome-intervals-coverage-analysis/SKILL.md +300 -0
- package/data/skills/bio-genome-intervals-gtf-gff-handling/SKILL.md +345 -0
- package/data/skills/bio-genome-intervals-interval-arithmetic/SKILL.md +485 -0
- package/data/skills/bio-genome-intervals-proximity-operations/SKILL.md +337 -0
- package/data/skills/bio-geo-data/SKILL.md +380 -0
- package/data/skills/bio-hi-c-analysis-compartment-analysis/SKILL.md +261 -0
- package/data/skills/bio-hi-c-analysis-contact-pairs/SKILL.md +278 -0
- package/data/skills/bio-hi-c-analysis-hic-data-io/SKILL.md +260 -0
- package/data/skills/bio-hi-c-analysis-hic-differential/SKILL.md +328 -0
- package/data/skills/bio-hi-c-analysis-hic-visualization/SKILL.md +297 -0
- package/data/skills/bio-hi-c-analysis-loop-calling/SKILL.md +284 -0
- package/data/skills/bio-hi-c-analysis-matrix-operations/SKILL.md +274 -0
- package/data/skills/bio-hi-c-analysis-tad-detection/SKILL.md +239 -0
- package/data/skills/bio-imaging-mass-cytometry-cell-segmentation/SKILL.md +241 -0
- package/data/skills/bio-imaging-mass-cytometry-data-preprocessing/SKILL.md +279 -0
- package/data/skills/bio-imaging-mass-cytometry-interactive-annotation/SKILL.md +304 -0
- package/data/skills/bio-imaging-mass-cytometry-phenotyping/SKILL.md +231 -0
- package/data/skills/bio-imaging-mass-cytometry-quality-metrics/SKILL.md +316 -0
- package/data/skills/bio-imaging-mass-cytometry-spatial-analysis/SKILL.md +246 -0
- package/data/skills/bio-immunoinformatics-epitope-prediction/SKILL.md +259 -0
- package/data/skills/bio-immunoinformatics-immunogenicity-scoring/SKILL.md +275 -0
- package/data/skills/bio-immunoinformatics-mhc-binding-prediction/SKILL.md +260 -0
- package/data/skills/bio-immunoinformatics-neoantigen-prediction/SKILL.md +277 -0
- package/data/skills/bio-immunoinformatics-tcr-epitope-binding/SKILL.md +257 -0
- package/data/skills/bio-isoform-switching/SKILL.md +192 -0
- package/data/skills/bio-liquid-biopsy-pipeline/SKILL.md +311 -0
- package/data/skills/bio-local-blast/SKILL.md +350 -0
- package/data/skills/bio-long-read-sequencing-clair3-variants/SKILL.md +252 -0
- package/data/skills/bio-long-read-sequencing-isoseq-analysis/SKILL.md +334 -0
- package/data/skills/bio-long-read-sequencing-nanopore-methylation/SKILL.md +110 -0
- package/data/skills/bio-longitudinal-monitoring/SKILL.md +271 -0
- package/data/skills/bio-longread-alignment/SKILL.md +193 -0
- package/data/skills/bio-longread-medaka/SKILL.md +176 -0
- package/data/skills/bio-longread-qc/SKILL.md +224 -0
- package/data/skills/bio-longread-structural-variants/SKILL.md +201 -0
- package/data/skills/bio-machine-learning-atlas-mapping/SKILL.md +139 -0
- package/data/skills/bio-machine-learning-biomarker-discovery/SKILL.md +157 -0
- package/data/skills/bio-machine-learning-model-validation/SKILL.md +148 -0
- package/data/skills/bio-machine-learning-omics-classifiers/SKILL.md +146 -0
- package/data/skills/bio-machine-learning-prediction-explanation/SKILL.md +162 -0
- package/data/skills/bio-machine-learning-survival-analysis/SKILL.md +176 -0
- package/data/skills/bio-metabolomics-lipidomics/SKILL.md +265 -0
- package/data/skills/bio-metabolomics-metabolite-annotation/SKILL.md +241 -0
- package/data/skills/bio-metabolomics-msdial-preprocessing/SKILL.md +308 -0
- package/data/skills/bio-metabolomics-normalization-qc/SKILL.md +283 -0
- package/data/skills/bio-metabolomics-pathway-mapping/SKILL.md +237 -0
- package/data/skills/bio-metabolomics-statistical-analysis/SKILL.md +276 -0
- package/data/skills/bio-metabolomics-targeted-analysis/SKILL.md +314 -0
- package/data/skills/bio-metabolomics-xcms-preprocessing/SKILL.md +268 -0
- package/data/skills/bio-metagenomics-abundance/SKILL.md +203 -0
- package/data/skills/bio-metagenomics-amr-detection/SKILL.md +293 -0
- package/data/skills/bio-metagenomics-functional-profiling/SKILL.md +252 -0
- package/data/skills/bio-metagenomics-kraken/SKILL.md +204 -0
- package/data/skills/bio-metagenomics-metaphlan/SKILL.md +214 -0
- package/data/skills/bio-metagenomics-strain-tracking/SKILL.md +292 -0
- package/data/skills/bio-metagenomics-visualization/SKILL.md +240 -0
- package/data/skills/bio-methylation-based-detection/SKILL.md +223 -0
- package/data/skills/bio-methylation-bismark-alignment/SKILL.md +195 -0
- package/data/skills/bio-methylation-calling/SKILL.md +200 -0
- package/data/skills/bio-methylation-dmr-detection/SKILL.md +211 -0
- package/data/skills/bio-methylation-methylkit/SKILL.md +219 -0
- package/data/skills/bio-microbiome-amplicon-processing/SKILL.md +137 -0
- package/data/skills/bio-microbiome-differential-abundance/SKILL.md +147 -0
- package/data/skills/bio-microbiome-diversity-analysis/SKILL.md +188 -0
- package/data/skills/bio-microbiome-functional-prediction/SKILL.md +153 -0
- package/data/skills/bio-microbiome-qiime2-workflow/SKILL.md +219 -0
- package/data/skills/bio-microbiome-taxonomy-assignment/SKILL.md +168 -0
- package/data/skills/bio-molecular-descriptors/SKILL.md +200 -0
- package/data/skills/bio-molecular-io/SKILL.md +188 -0
- package/data/skills/bio-motif-search/SKILL.md +354 -0
- package/data/skills/bio-multi-omics-data-harmonization/SKILL.md +228 -0
- package/data/skills/bio-multi-omics-mixomics-analysis/SKILL.md +221 -0
- package/data/skills/bio-multi-omics-mofa-integration/SKILL.md +225 -0
- package/data/skills/bio-multi-omics-similarity-network/SKILL.md +235 -0
- package/data/skills/bio-orchestrator/SKILL.md +133 -0
- package/data/skills/bio-paired-end-fastq/SKILL.md +334 -0
- package/data/skills/bio-pathway-enrichment-visualization/SKILL.md +278 -0
- package/data/skills/bio-pathway-go-enrichment/SKILL.md +218 -0
- package/data/skills/bio-pathway-gsea/SKILL.md +227 -0
- package/data/skills/bio-pathway-kegg-pathways/SKILL.md +234 -0
- package/data/skills/bio-pathway-reactome/SKILL.md +215 -0
- package/data/skills/bio-pathway-wikipathways/SKILL.md +255 -0
- package/data/skills/bio-pdb-geometric-analysis/SKILL.md +475 -0
- package/data/skills/bio-pdb-structure-io/SKILL.md +296 -0
- package/data/skills/bio-pdb-structure-modification/SKILL.md +448 -0
- package/data/skills/bio-pdb-structure-navigation/SKILL.md +335 -0
- package/data/skills/bio-phasing-imputation-genotype-imputation/SKILL.md +201 -0
- package/data/skills/bio-phasing-imputation-haplotype-phasing/SKILL.md +190 -0
- package/data/skills/bio-phasing-imputation-imputation-qc/SKILL.md +265 -0
- package/data/skills/bio-phasing-imputation-reference-panels/SKILL.md +203 -0
- package/data/skills/bio-phylo-distance-calculations/SKILL.md +307 -0
- package/data/skills/bio-phylo-modern-tree-inference/SKILL.md +274 -0
- package/data/skills/bio-phylo-tree-io/SKILL.md +252 -0
- package/data/skills/bio-phylo-tree-manipulation/SKILL.md +375 -0
- package/data/skills/bio-phylo-tree-visualization/SKILL.md +275 -0
- package/data/skills/bio-pileup-generation/SKILL.md +314 -0
- package/data/skills/bio-population-genetics-association-testing/SKILL.md +293 -0
- package/data/skills/bio-population-genetics-linkage-disequilibrium/SKILL.md +260 -0
- package/data/skills/bio-population-genetics-plink-basics/SKILL.md +338 -0
- package/data/skills/bio-population-genetics-population-structure/SKILL.md +352 -0
- package/data/skills/bio-population-genetics-scikit-allel-analysis/SKILL.md +306 -0
- package/data/skills/bio-population-genetics-selection-statistics/SKILL.md +251 -0
- package/data/skills/bio-primer-design-primer-basics/SKILL.md +289 -0
- package/data/skills/bio-primer-design-primer-validation/SKILL.md +344 -0
- package/data/skills/bio-primer-design-qpcr-primers/SKILL.md +273 -0
- package/data/skills/bio-proteomics-data-import/SKILL.md +122 -0
- package/data/skills/bio-proteomics-dia-analysis/SKILL.md +246 -0
- package/data/skills/bio-proteomics-differential-abundance/SKILL.md +129 -0
- package/data/skills/bio-proteomics-peptide-identification/SKILL.md +122 -0
- package/data/skills/bio-proteomics-protein-inference/SKILL.md +174 -0
- package/data/skills/bio-proteomics-proteomics-qc/SKILL.md +208 -0
- package/data/skills/bio-proteomics-ptm-analysis/SKILL.md +139 -0
- package/data/skills/bio-proteomics-quantification/SKILL.md +141 -0
- package/data/skills/bio-proteomics-spectral-libraries/SKILL.md +270 -0
- package/data/skills/bio-reaction-enumeration/SKILL.md +251 -0
- package/data/skills/bio-read-alignment-bowtie2-alignment/SKILL.md +189 -0
- package/data/skills/bio-read-alignment-bwa-alignment/SKILL.md +166 -0
- package/data/skills/bio-read-alignment-hisat2-alignment/SKILL.md +205 -0
- package/data/skills/bio-read-alignment-star-alignment/SKILL.md +204 -0
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- package/data/workflows/pooled-crispr-screens/scripts/differential_expression_glmgampoi.py +320 -0
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- package/data/workflows/pooled-crispr-screens/scripts/gene_name_corrections.py +188 -0
- package/data/workflows/pooled-crispr-screens/scripts/generate_report.py +485 -0
- package/data/workflows/pooled-crispr-screens/scripts/load_10x_libraries.py +69 -0
- package/data/workflows/pooled-crispr-screens/scripts/load_example_data.py +257 -0
- package/data/workflows/pooled-crispr-screens/scripts/map_sgrna_to_cells.py +119 -0
- package/data/workflows/pooled-crispr-screens/scripts/normalize_and_scale.py +140 -0
- package/data/workflows/pooled-crispr-screens/scripts/qc_filtering.py +185 -0
- package/data/workflows/pooled-crispr-screens/scripts/run_glmgampoi.R +181 -0
- package/data/workflows/pooled-crispr-screens/scripts/screen_all_perturbations.py +306 -0
- package/data/workflows/pooled-crispr-screens/scripts/validate_perturbations.py +314 -0
- package/data/workflows/pooled-crispr-screens/scripts/visualize_perturbations.py +314 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/SKILL.md +425 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/references/ambient_rna_correction.md +422 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/references/common-patterns.md +533 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/references/integration_methods.md +820 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/references/marker_gene_database.md +471 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/references/pseudobulk_de_guide.md +408 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/references/qc_guidelines.md +535 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/references/scanpy_best_practices.md +496 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/references/troubleshooting_guide.md +668 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/references/workflow-details.md +727 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/annotate_celltypes.py +431 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/cluster_cells.py +293 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/export_results.py +423 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/filter_cells.py +531 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/find_markers.py +391 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/find_variable_genes.py +222 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/integrate_scvi.py +665 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/integration_diagnostics.py +678 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/load_example_data.py +68 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/normalize_data.py +325 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/plot_dimreduction.py +389 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/plot_qc.py +320 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/pseudobulk_de.py +553 -0
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- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/remove_ambient_rna.py +347 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/run_umap.py +188 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/scale_and_pca.py +365 -0
- package/data/workflows/scrnaseq-scanpy-core-analysis/scripts/setup_and_import.py +334 -0
- package/data/workflows/scrnaseq-seurat-core-analysis/SKILL.md +585 -0
- package/data/workflows/scrnaseq-seurat-core-analysis/references/ambient_rna_correction.md +422 -0
- package/data/workflows/scrnaseq-seurat-core-analysis/references/common-patterns.md +667 -0
- package/data/workflows/scrnaseq-seurat-core-analysis/references/decision-guide.md +456 -0
- package/data/workflows/scrnaseq-seurat-core-analysis/references/integration_methods.md +864 -0
- package/data/workflows/scrnaseq-seurat-core-analysis/references/marker_gene_database.md +471 -0
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- package/data/workflows/scrnaseq-seurat-core-analysis/references/qc_guidelines.md +452 -0
- package/data/workflows/scrnaseq-seurat-core-analysis/references/seurat_best_practices.md +417 -0
- package/data/workflows/scrnaseq-seurat-core-analysis/references/troubleshooting_guide.md +566 -0
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- package/data/workflows/scrnaseq-seurat-core-analysis/scripts/annotate_celltypes.R +306 -0
- package/data/workflows/scrnaseq-seurat-core-analysis/scripts/cluster_cells.R +223 -0
- package/data/workflows/scrnaseq-seurat-core-analysis/scripts/export_results.R +292 -0
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- package/data/workflows/spatial-transcriptomics/scripts/spatial_workflow.py +206 -0
- package/dist/bgi.js +28 -1
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---
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name: uspto-database
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description: "Access USPTO APIs for patent/trademark searches, examination history (PEDS), assignments, citations, office actions, TSDR, for IP analysis and prior art searches."
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---
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# USPTO Database
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## Overview
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USPTO provides specialized APIs for patent and trademark data. Search patents by keywords/inventors/assignees, retrieve examination history via PEDS, track assignments, analyze citations and office actions, access TSDR for trademarks, for IP analysis and prior art searches.
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## When to Use This Skill
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This skill should be used when:
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- **Patent Search**: Finding patents by keywords, inventors, assignees, classifications, or dates
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- **Patent Details**: Retrieving full patent data including claims, abstracts, citations
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- **Trademark Search**: Looking up trademarks by serial or registration number
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- **Trademark Status**: Checking trademark status, ownership, and prosecution history
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- **Examination History**: Accessing patent prosecution data from PEDS (Patent Examination Data System)
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- **Office Actions**: Retrieving office action text, citations, and rejections
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- **Assignments**: Tracking patent/trademark ownership transfers
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- **Citations**: Analyzing patent citations (forward and backward)
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- **Litigation**: Accessing patent litigation records
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- **Portfolio Analysis**: Analyzing patent/trademark portfolios for companies or inventors
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## USPTO API Ecosystem
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The USPTO provides multiple specialized APIs for different data needs:
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### Core APIs
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1. **PatentSearch API** - Modern ElasticSearch-based patent search (replaced legacy PatentsView in May 2025)
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- Search patents by keywords, inventors, assignees, classifications, dates
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- Access to patent data through June 30, 2025
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- 45 requests/minute rate limit
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- **Base URL**: `https://search.patentsview.org/api/v1/`
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2. **PEDS (Patent Examination Data System)** - Patent examination history
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- Application status and transaction history from 1981-present
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- Office action dates and examination events
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- Use `uspto-opendata-python` Python library
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- **Replaced**: PAIR Bulk Data (PBD) - decommissioned
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3. **TSDR (Trademark Status & Document Retrieval)** - Trademark data
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- Trademark status, ownership, prosecution history
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- Search by serial or registration number
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- **Base URL**: `https://tsdrapi.uspto.gov/ts/cd/`
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### Additional APIs
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4. **Patent Assignment Search** - Ownership records and transfers
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5. **Trademark Assignment Search** - Trademark ownership changes
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6. **Enriched Citation API** - Patent citation analysis
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7. **Office Action Text Retrieval** - Full text of office actions
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8. **Office Action Citations** - Citations from office actions
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9. **Office Action Rejection** - Rejection reasons and types
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10. **PTAB API** - Patent Trial and Appeal Board proceedings
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11. **Patent Litigation Cases** - Federal district court litigation data
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12. **Cancer Moonshot Data Set** - Cancer-related patents
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## Quick Start
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### API Key Registration
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All USPTO APIs require an API key. Register at:
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**https://account.uspto.gov/api-manager/**
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Set the API key as an environment variable:
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```bash
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export USPTO_API_KEY="your_api_key_here"
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```
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### Helper Scripts
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This skill includes Python scripts for common operations:
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- **`scripts/patent_search.py`** - PatentSearch API client for searching patents
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- **`scripts/peds_client.py`** - PEDS client for examination history
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- **`scripts/trademark_client.py`** - TSDR client for trademark data
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## Task 1: Searching Patents
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### Using the PatentSearch API
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The PatentSearch API uses a JSON query language with various operators for flexible searching.
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#### Basic Patent Search Examples
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**Search by keywords in abstract:**
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```python
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from scripts.patent_search import PatentSearchClient
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client = PatentSearchClient()
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# Search for machine learning patents
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results = client.search_patents({
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})
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for patent in results['patents']:
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print(f"{patent['patent_number']}: {patent['patent_title']}")
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```
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**Search by inventor:**
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```python
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results = client.search_by_inventor("John Smith")
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```
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**Search by assignee/company:**
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```python
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results = client.search_by_assignee("Google")
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```
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**Search by date range:**
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```python
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results = client.search_by_date_range("2024-01-01", "2024-12-31")
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```
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**Search by CPC classification:**
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```python
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results = client.search_by_classification("H04N") # Video/image tech
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```
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#### Advanced Patent Search
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Combine multiple criteria with logical operators:
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```python
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results = client.advanced_search(
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keywords=["artificial", "intelligence"],
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assignee="Microsoft",
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start_date="2023-01-01",
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end_date="2024-12-31",
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cpc_codes=["G06N", "G06F"] # AI and computing classifications
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)
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```
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#### Direct API Usage
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For complex queries, use the API directly:
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```python
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import requests
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url = "https://search.patentsview.org/api/v1/patent"
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headers = {
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"X-Api-Key": "YOUR_API_KEY",
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"Content-Type": "application/json"
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}
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query = {
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"q": {
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"_and": [
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{"patent_date": {"_gte": "2024-01-01"}},
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{"assignee_organization": {"_text_any": ["Google", "Alphabet"]}},
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{"cpc_subclass_id": ["G06N", "H04N"]}
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]
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"f": ["patent_number", "patent_title", "patent_date", "inventor_name"],
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"s": [{"patent_date": "desc"}],
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"o": {"per_page": 100, "page": 1}
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}
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response = requests.post(url, headers=headers, json=query)
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results = response.json()
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```
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### Query Operators
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- **Equality**: `{"field": "value"}` or `{"field": {"_eq": "value"}}`
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|
172
|
+
- **Comparison**: `_gt`, `_gte`, `_lt`, `_lte`, `_neq`
|
|
173
|
+
- **Text search**: `_text_all`, `_text_any`, `_text_phrase`
|
|
174
|
+
- **String matching**: `_begins`, `_contains`
|
|
175
|
+
- **Logical**: `_and`, `_or`, `_not`
|
|
176
|
+
|
|
177
|
+
**Best Practice**: Use `_text_*` operators for text fields (more performant than `_contains` or `_begins`)
|
|
178
|
+
|
|
179
|
+
### Available Patent Endpoints
|
|
180
|
+
|
|
181
|
+
- `/patent` - Granted patents
|
|
182
|
+
- `/publication` - Pregrant publications
|
|
183
|
+
- `/inventor` - Inventor information
|
|
184
|
+
- `/assignee` - Assignee information
|
|
185
|
+
- `/cpc_subclass`, `/cpc_at_issue` - CPC classifications
|
|
186
|
+
- `/uspc` - US Patent Classification
|
|
187
|
+
- `/ipc` - International Patent Classification
|
|
188
|
+
- `/claims`, `/brief_summary_text`, `/detail_description_text` - Text data (beta)
|
|
189
|
+
|
|
190
|
+
### Reference Documentation
|
|
191
|
+
|
|
192
|
+
See `references/patentsearch_api.md` for complete PatentSearch API documentation including:
|
|
193
|
+
- All available endpoints
|
|
194
|
+
- Complete field reference
|
|
195
|
+
- Query syntax and examples
|
|
196
|
+
- Response formats
|
|
197
|
+
- Rate limits and best practices
|
|
198
|
+
|
|
199
|
+
## Task 2: Retrieving Patent Examination Data
|
|
200
|
+
|
|
201
|
+
### Using PEDS (Patent Examination Data System)
|
|
202
|
+
|
|
203
|
+
PEDS provides comprehensive prosecution history including transaction events, status changes, and examination timeline.
|
|
204
|
+
|
|
205
|
+
#### Installation
|
|
206
|
+
|
|
207
|
+
```bash
|
|
208
|
+
uv pip install uspto-opendata-python
|
|
209
|
+
```
|
|
210
|
+
|
|
211
|
+
#### Basic PEDS Usage
|
|
212
|
+
|
|
213
|
+
**Get application data:**
|
|
214
|
+
```python
|
|
215
|
+
from scripts.peds_client import PEDSHelper
|
|
216
|
+
|
|
217
|
+
helper = PEDSHelper()
|
|
218
|
+
|
|
219
|
+
# By application number
|
|
220
|
+
app_data = helper.get_application("16123456")
|
|
221
|
+
print(f"Title: {app_data['title']}")
|
|
222
|
+
print(f"Status: {app_data['app_status']}")
|
|
223
|
+
|
|
224
|
+
# By patent number
|
|
225
|
+
patent_data = helper.get_patent("11234567")
|
|
226
|
+
```
|
|
227
|
+
|
|
228
|
+
**Get transaction history:**
|
|
229
|
+
```python
|
|
230
|
+
transactions = helper.get_transaction_history("16123456")
|
|
231
|
+
|
|
232
|
+
for trans in transactions:
|
|
233
|
+
print(f"{trans['date']}: {trans['code']} - {trans['description']}")
|
|
234
|
+
```
|
|
235
|
+
|
|
236
|
+
**Get office actions:**
|
|
237
|
+
```python
|
|
238
|
+
office_actions = helper.get_office_actions("16123456")
|
|
239
|
+
|
|
240
|
+
for oa in office_actions:
|
|
241
|
+
if oa['code'] == 'CTNF':
|
|
242
|
+
print(f"Non-final rejection: {oa['date']}")
|
|
243
|
+
elif oa['code'] == 'CTFR':
|
|
244
|
+
print(f"Final rejection: {oa['date']}")
|
|
245
|
+
elif oa['code'] == 'NOA':
|
|
246
|
+
print(f"Notice of allowance: {oa['date']}")
|
|
247
|
+
```
|
|
248
|
+
|
|
249
|
+
**Get status summary:**
|
|
250
|
+
```python
|
|
251
|
+
summary = helper.get_status_summary("16123456")
|
|
252
|
+
|
|
253
|
+
print(f"Current status: {summary['current_status']}")
|
|
254
|
+
print(f"Filing date: {summary['filing_date']}")
|
|
255
|
+
print(f"Pendency: {summary['pendency_days']} days")
|
|
256
|
+
|
|
257
|
+
if summary['is_patented']:
|
|
258
|
+
print(f"Patent number: {summary['patent_number']}")
|
|
259
|
+
print(f"Issue date: {summary['issue_date']}")
|
|
260
|
+
```
|
|
261
|
+
|
|
262
|
+
#### Prosecution Analysis
|
|
263
|
+
|
|
264
|
+
Analyze prosecution patterns:
|
|
265
|
+
|
|
266
|
+
```python
|
|
267
|
+
analysis = helper.analyze_prosecution("16123456")
|
|
268
|
+
|
|
269
|
+
print(f"Total office actions: {analysis['total_office_actions']}")
|
|
270
|
+
print(f"Non-final rejections: {analysis['non_final_rejections']}")
|
|
271
|
+
print(f"Final rejections: {analysis['final_rejections']}")
|
|
272
|
+
print(f"Allowed: {analysis['allowance']}")
|
|
273
|
+
print(f"Responses filed: {analysis['responses']}")
|
|
274
|
+
```
|
|
275
|
+
|
|
276
|
+
### Common Transaction Codes
|
|
277
|
+
|
|
278
|
+
- **CTNF** - Non-final rejection mailed
|
|
279
|
+
- **CTFR** - Final rejection mailed
|
|
280
|
+
- **NOA** - Notice of allowance mailed
|
|
281
|
+
- **WRIT** - Response filed
|
|
282
|
+
- **ISS.FEE** - Issue fee payment
|
|
283
|
+
- **ABND** - Application abandoned
|
|
284
|
+
- **AOPF** - Office action mailed
|
|
285
|
+
|
|
286
|
+
### Reference Documentation
|
|
287
|
+
|
|
288
|
+
See `references/peds_api.md` for complete PEDS documentation including:
|
|
289
|
+
- All available data fields
|
|
290
|
+
- Transaction code reference
|
|
291
|
+
- Python library usage
|
|
292
|
+
- Portfolio analysis examples
|
|
293
|
+
|
|
294
|
+
## Task 3: Searching and Monitoring Trademarks
|
|
295
|
+
|
|
296
|
+
### Using TSDR (Trademark Status & Document Retrieval)
|
|
297
|
+
|
|
298
|
+
Access trademark status, ownership, and prosecution history.
|
|
299
|
+
|
|
300
|
+
#### Basic Trademark Usage
|
|
301
|
+
|
|
302
|
+
**Get trademark by serial number:**
|
|
303
|
+
```python
|
|
304
|
+
from scripts.trademark_client import TrademarkClient
|
|
305
|
+
|
|
306
|
+
client = TrademarkClient()
|
|
307
|
+
|
|
308
|
+
# By serial number
|
|
309
|
+
tm_data = client.get_trademark_by_serial("87654321")
|
|
310
|
+
|
|
311
|
+
# By registration number
|
|
312
|
+
tm_data = client.get_trademark_by_registration("5678901")
|
|
313
|
+
```
|
|
314
|
+
|
|
315
|
+
**Get trademark status:**
|
|
316
|
+
```python
|
|
317
|
+
status = client.get_trademark_status("87654321")
|
|
318
|
+
|
|
319
|
+
print(f"Mark: {status['mark_text']}")
|
|
320
|
+
print(f"Status: {status['status']}")
|
|
321
|
+
print(f"Filing date: {status['filing_date']}")
|
|
322
|
+
|
|
323
|
+
if status['is_registered']:
|
|
324
|
+
print(f"Registration #: {status['registration_number']}")
|
|
325
|
+
print(f"Registration date: {status['registration_date']}")
|
|
326
|
+
```
|
|
327
|
+
|
|
328
|
+
**Check trademark health:**
|
|
329
|
+
```python
|
|
330
|
+
health = client.check_trademark_health("87654321")
|
|
331
|
+
|
|
332
|
+
print(f"Mark: {health['mark']}")
|
|
333
|
+
print(f"Status: {health['status']}")
|
|
334
|
+
|
|
335
|
+
for alert in health['alerts']:
|
|
336
|
+
print(alert)
|
|
337
|
+
|
|
338
|
+
if health['needs_attention']:
|
|
339
|
+
print("⚠️ This mark needs attention!")
|
|
340
|
+
```
|
|
341
|
+
|
|
342
|
+
#### Trademark Portfolio Monitoring
|
|
343
|
+
|
|
344
|
+
Monitor multiple trademarks:
|
|
345
|
+
|
|
346
|
+
```python
|
|
347
|
+
def monitor_portfolio(serial_numbers, api_key):
|
|
348
|
+
"""Monitor trademark portfolio health."""
|
|
349
|
+
client = TrademarkClient(api_key)
|
|
350
|
+
|
|
351
|
+
results = {
|
|
352
|
+
'active': [],
|
|
353
|
+
'pending': [],
|
|
354
|
+
'problems': []
|
|
355
|
+
}
|
|
356
|
+
|
|
357
|
+
for sn in serial_numbers:
|
|
358
|
+
health = client.check_trademark_health(sn)
|
|
359
|
+
|
|
360
|
+
if 'REGISTERED' in health['status']:
|
|
361
|
+
results['active'].append(health)
|
|
362
|
+
elif 'PENDING' in health['status'] or 'PUBLISHED' in health['status']:
|
|
363
|
+
results['pending'].append(health)
|
|
364
|
+
elif health['needs_attention']:
|
|
365
|
+
results['problems'].append(health)
|
|
366
|
+
|
|
367
|
+
return results
|
|
368
|
+
```
|
|
369
|
+
|
|
370
|
+
### Common Trademark Statuses
|
|
371
|
+
|
|
372
|
+
- **REGISTERED** - Active registered mark
|
|
373
|
+
- **PENDING** - Under examination
|
|
374
|
+
- **PUBLISHED FOR OPPOSITION** - In opposition period
|
|
375
|
+
- **ABANDONED** - Application abandoned
|
|
376
|
+
- **CANCELLED** - Registration cancelled
|
|
377
|
+
- **SUSPENDED** - Examination suspended
|
|
378
|
+
- **REGISTERED AND RENEWED** - Registration renewed
|
|
379
|
+
|
|
380
|
+
### Reference Documentation
|
|
381
|
+
|
|
382
|
+
See `references/trademark_api.md` for complete trademark API documentation including:
|
|
383
|
+
- TSDR API reference
|
|
384
|
+
- Trademark Assignment Search API
|
|
385
|
+
- All status codes
|
|
386
|
+
- Prosecution history access
|
|
387
|
+
- Ownership tracking
|
|
388
|
+
|
|
389
|
+
## Task 4: Tracking Assignments and Ownership
|
|
390
|
+
|
|
391
|
+
### Patent and Trademark Assignments
|
|
392
|
+
|
|
393
|
+
Both patents and trademarks have Assignment Search APIs for tracking ownership changes.
|
|
394
|
+
|
|
395
|
+
#### Patent Assignment API
|
|
396
|
+
|
|
397
|
+
**Base URL**: `https://assignment-api.uspto.gov/patent/v1.4/`
|
|
398
|
+
|
|
399
|
+
**Search by patent number:**
|
|
400
|
+
```python
|
|
401
|
+
import requests
|
|
402
|
+
import xml.etree.ElementTree as ET
|
|
403
|
+
|
|
404
|
+
def get_patent_assignments(patent_number, api_key):
|
|
405
|
+
url = f"https://assignment-api.uspto.gov/patent/v1.4/assignment/patent/{patent_number}"
|
|
406
|
+
headers = {"X-Api-Key": api_key}
|
|
407
|
+
|
|
408
|
+
response = requests.get(url, headers=headers)
|
|
409
|
+
if response.status_code == 200:
|
|
410
|
+
return response.text # Returns XML
|
|
411
|
+
|
|
412
|
+
assignments_xml = get_patent_assignments("11234567", api_key)
|
|
413
|
+
root = ET.fromstring(assignments_xml)
|
|
414
|
+
|
|
415
|
+
for assignment in root.findall('.//assignment'):
|
|
416
|
+
recorded_date = assignment.find('recordedDate').text
|
|
417
|
+
assignor = assignment.find('.//assignor/name').text
|
|
418
|
+
assignee = assignment.find('.//assignee/name').text
|
|
419
|
+
conveyance = assignment.find('conveyanceText').text
|
|
420
|
+
|
|
421
|
+
print(f"{recorded_date}: {assignor} → {assignee}")
|
|
422
|
+
print(f" Type: {conveyance}\n")
|
|
423
|
+
```
|
|
424
|
+
|
|
425
|
+
**Search by company name:**
|
|
426
|
+
```python
|
|
427
|
+
def find_company_patents(company_name, api_key):
|
|
428
|
+
url = "https://assignment-api.uspto.gov/patent/v1.4/assignment/search"
|
|
429
|
+
headers = {"X-Api-Key": api_key}
|
|
430
|
+
data = {"criteria": {"assigneeName": company_name}}
|
|
431
|
+
|
|
432
|
+
response = requests.post(url, headers=headers, json=data)
|
|
433
|
+
return response.text
|
|
434
|
+
```
|
|
435
|
+
|
|
436
|
+
### Common Assignment Types
|
|
437
|
+
|
|
438
|
+
- **ASSIGNMENT OF ASSIGNORS INTEREST** - Ownership transfer
|
|
439
|
+
- **SECURITY AGREEMENT** - Collateral/security interest
|
|
440
|
+
- **MERGER** - Corporate merger
|
|
441
|
+
- **CHANGE OF NAME** - Name change
|
|
442
|
+
- **ASSIGNMENT OF PARTIAL INTEREST** - Partial ownership
|
|
443
|
+
|
|
444
|
+
## Task 5: Accessing Additional USPTO Data
|
|
445
|
+
|
|
446
|
+
### Office Actions, Citations, and Litigation
|
|
447
|
+
|
|
448
|
+
Multiple specialized APIs provide additional patent data.
|
|
449
|
+
|
|
450
|
+
#### Office Action Text Retrieval
|
|
451
|
+
|
|
452
|
+
Retrieve full text of office actions using application number. Integrate with PEDS to identify which office actions exist, then retrieve full text.
|
|
453
|
+
|
|
454
|
+
#### Enriched Citation API
|
|
455
|
+
|
|
456
|
+
Analyze patent citations:
|
|
457
|
+
- Forward citations (patents citing this patent)
|
|
458
|
+
- Backward citations (prior art cited)
|
|
459
|
+
- Examiner vs. applicant citations
|
|
460
|
+
- Citation context
|
|
461
|
+
|
|
462
|
+
#### Patent Litigation Cases API
|
|
463
|
+
|
|
464
|
+
Access federal district court patent litigation records:
|
|
465
|
+
- 74,623+ litigation records
|
|
466
|
+
- Patents asserted
|
|
467
|
+
- Parties and venues
|
|
468
|
+
- Case outcomes
|
|
469
|
+
|
|
470
|
+
#### PTAB API
|
|
471
|
+
|
|
472
|
+
Patent Trial and Appeal Board proceedings:
|
|
473
|
+
- Inter partes review (IPR)
|
|
474
|
+
- Post-grant review (PGR)
|
|
475
|
+
- Appeal decisions
|
|
476
|
+
|
|
477
|
+
### Reference Documentation
|
|
478
|
+
|
|
479
|
+
See `references/additional_apis.md` for comprehensive documentation on:
|
|
480
|
+
- Enriched Citation API
|
|
481
|
+
- Office Action APIs (Text, Citations, Rejections)
|
|
482
|
+
- Patent Litigation Cases API
|
|
483
|
+
- PTAB API
|
|
484
|
+
- Cancer Moonshot Data Set
|
|
485
|
+
- OCE Status/Event Codes
|
|
486
|
+
|
|
487
|
+
## Complete Analysis Example
|
|
488
|
+
|
|
489
|
+
### Comprehensive Patent Analysis
|
|
490
|
+
|
|
491
|
+
Combine multiple APIs for complete patent intelligence:
|
|
492
|
+
|
|
493
|
+
```python
|
|
494
|
+
def comprehensive_patent_analysis(patent_number, api_key):
|
|
495
|
+
"""
|
|
496
|
+
Full patent analysis using multiple USPTO APIs.
|
|
497
|
+
"""
|
|
498
|
+
from scripts.patent_search import PatentSearchClient
|
|
499
|
+
from scripts.peds_client import PEDSHelper
|
|
500
|
+
|
|
501
|
+
results = {}
|
|
502
|
+
|
|
503
|
+
# 1. Get patent details
|
|
504
|
+
patent_client = PatentSearchClient(api_key)
|
|
505
|
+
patent_data = patent_client.get_patent(patent_number)
|
|
506
|
+
results['patent'] = patent_data
|
|
507
|
+
|
|
508
|
+
# 2. Get examination history
|
|
509
|
+
peds = PEDSHelper()
|
|
510
|
+
results['prosecution'] = peds.analyze_prosecution(patent_number)
|
|
511
|
+
results['status'] = peds.get_status_summary(patent_number)
|
|
512
|
+
|
|
513
|
+
# 3. Get assignment history
|
|
514
|
+
import requests
|
|
515
|
+
assign_url = f"https://assignment-api.uspto.gov/patent/v1.4/assignment/patent/{patent_number}"
|
|
516
|
+
assign_resp = requests.get(assign_url, headers={"X-Api-Key": api_key})
|
|
517
|
+
results['assignments'] = assign_resp.text if assign_resp.status_code == 200 else None
|
|
518
|
+
|
|
519
|
+
# 4. Analyze results
|
|
520
|
+
print(f"\n=== Patent {patent_number} Analysis ===\n")
|
|
521
|
+
print(f"Title: {patent_data['patent_title']}")
|
|
522
|
+
print(f"Assignee: {', '.join(patent_data.get('assignee_organization', []))}")
|
|
523
|
+
print(f"Issue Date: {patent_data['patent_date']}")
|
|
524
|
+
|
|
525
|
+
print(f"\nProsecution:")
|
|
526
|
+
print(f" Office Actions: {results['prosecution']['total_office_actions']}")
|
|
527
|
+
print(f" Rejections: {results['prosecution']['non_final_rejections']} non-final, {results['prosecution']['final_rejections']} final")
|
|
528
|
+
print(f" Pendency: {results['prosecution']['pendency_days']} days")
|
|
529
|
+
|
|
530
|
+
# Analyze citations
|
|
531
|
+
if 'cited_patent_number' in patent_data:
|
|
532
|
+
print(f"\nCitations:")
|
|
533
|
+
print(f" Cites: {len(patent_data['cited_patent_number'])} patents")
|
|
534
|
+
if 'citedby_patent_number' in patent_data:
|
|
535
|
+
print(f" Cited by: {len(patent_data['citedby_patent_number'])} patents")
|
|
536
|
+
|
|
537
|
+
return results
|
|
538
|
+
```
|
|
539
|
+
|
|
540
|
+
## Best Practices
|
|
541
|
+
|
|
542
|
+
1. **API Key Management**
|
|
543
|
+
- Store API key in environment variables
|
|
544
|
+
- Never commit keys to version control
|
|
545
|
+
- Use same key across all USPTO APIs
|
|
546
|
+
|
|
547
|
+
2. **Rate Limiting**
|
|
548
|
+
- PatentSearch: 45 requests/minute
|
|
549
|
+
- Implement exponential backoff for rate limit errors
|
|
550
|
+
- Cache responses when possible
|
|
551
|
+
|
|
552
|
+
3. **Query Optimization**
|
|
553
|
+
- Use `_text_*` operators for text fields (more performant)
|
|
554
|
+
- Request only needed fields to reduce response size
|
|
555
|
+
- Use date ranges to narrow searches
|
|
556
|
+
|
|
557
|
+
4. **Data Handling**
|
|
558
|
+
- Not all fields populated for all patents/trademarks
|
|
559
|
+
- Handle missing data gracefully
|
|
560
|
+
- Parse dates consistently
|
|
561
|
+
|
|
562
|
+
5. **Combining APIs**
|
|
563
|
+
- Use PatentSearch for discovery
|
|
564
|
+
- Use PEDS for prosecution details
|
|
565
|
+
- Use Assignment APIs for ownership tracking
|
|
566
|
+
- Combine data for comprehensive analysis
|
|
567
|
+
|
|
568
|
+
## Important Notes
|
|
569
|
+
|
|
570
|
+
- **Legacy API Sunset**: PatentsView legacy API discontinued May 1, 2025 - use PatentSearch API
|
|
571
|
+
- **PAIR Bulk Data Decommissioned**: Use PEDS instead
|
|
572
|
+
- **Data Coverage**: PatentSearch has data through June 30, 2025; PEDS from 1981-present
|
|
573
|
+
- **Text Endpoints**: Claims and description endpoints are in beta with ongoing backfilling
|
|
574
|
+
- **Rate Limits**: Respect rate limits to avoid service disruptions
|
|
575
|
+
|
|
576
|
+
## Resources
|
|
577
|
+
|
|
578
|
+
### API Documentation
|
|
579
|
+
- **PatentSearch API**: https://search.patentsview.org/docs/
|
|
580
|
+
- **USPTO Developer Portal**: https://developer.uspto.gov/
|
|
581
|
+
- **USPTO Open Data Portal**: https://data.uspto.gov/
|
|
582
|
+
- **API Key Registration**: https://account.uspto.gov/api-manager/
|
|
583
|
+
|
|
584
|
+
### Python Libraries
|
|
585
|
+
- **uspto-opendata-python**: https://pypi.org/project/uspto-opendata-python/
|
|
586
|
+
- **USPTO Docs**: https://docs.ip-tools.org/uspto-opendata-python/
|
|
587
|
+
|
|
588
|
+
### Reference Files
|
|
589
|
+
- `references/patentsearch_api.md` - Complete PatentSearch API reference
|
|
590
|
+
- `references/peds_api.md` - PEDS API and library documentation
|
|
591
|
+
- `references/trademark_api.md` - Trademark APIs (TSDR and Assignment)
|
|
592
|
+
- `references/additional_apis.md` - Citations, Office Actions, Litigation, PTAB
|
|
593
|
+
|
|
594
|
+
### Scripts
|
|
595
|
+
- `scripts/patent_search.py` - PatentSearch API client
|
|
596
|
+
- `scripts/peds_client.py` - PEDS examination data client
|
|
597
|
+
- `scripts/trademark_client.py` - Trademark search client
|