@bgicli/bgicli 2.1.1 → 2.2.0

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (1266) hide show
  1. package/data/skills/aav-vector-design-agent/SKILL.md +198 -0
  2. package/data/skills/adaptyv/SKILL.md +112 -0
  3. package/data/skills/adhd-daily-planner/SKILL.md +271 -0
  4. package/data/skills/aeon/SKILL.md +372 -0
  5. package/data/skills/agent-browser/SKILL.md +159 -0
  6. package/data/skills/agentd-drug-discovery/SKILL.md +52 -0
  7. package/data/skills/ai-analyzer/SKILL.md +218 -0
  8. package/data/skills/alphafold/SKILL.md +183 -0
  9. package/data/skills/alphafold-database/SKILL.md +500 -0
  10. package/data/skills/anndata/SKILL.md +394 -0
  11. package/data/skills/antibody-design-agent/SKILL.md +64 -0
  12. package/data/skills/arboreto/SKILL.md +237 -0
  13. package/data/skills/armored-cart-design-agent/SKILL.md +225 -0
  14. package/data/skills/arxiv-search/SKILL.md +224 -0
  15. package/data/skills/autonomous-oncology-agent/SKILL.md +77 -0
  16. package/data/skills/bayesian-optimizer/SKILL.md +60 -0
  17. package/data/skills/benchling-integration/SKILL.md +473 -0
  18. package/data/skills/bgpt-paper-search/SKILL.md +81 -0
  19. package/data/skills/bindcraft/SKILL.md +198 -0
  20. package/data/skills/binder-design/SKILL.md +182 -0
  21. package/data/skills/binding-characterization/SKILL.md +234 -0
  22. package/data/skills/bindingdb-database/SKILL.md +332 -0
  23. package/data/skills/bio-admet-prediction/SKILL.md +224 -0
  24. package/data/skills/bio-alignment-files-bam-statistics/SKILL.md +340 -0
  25. package/data/skills/bio-alignment-filtering/SKILL.md +322 -0
  26. package/data/skills/bio-alignment-indexing/SKILL.md +249 -0
  27. package/data/skills/bio-alignment-io/SKILL.md +301 -0
  28. package/data/skills/bio-alignment-msa-parsing/SKILL.md +366 -0
  29. package/data/skills/bio-alignment-msa-statistics/SKILL.md +375 -0
  30. package/data/skills/bio-alignment-pairwise/SKILL.md +277 -0
  31. package/data/skills/bio-alignment-sorting/SKILL.md +296 -0
  32. package/data/skills/bio-alignment-validation/SKILL.md +374 -0
  33. package/data/skills/bio-atac-seq-atac-peak-calling/SKILL.md +221 -0
  34. package/data/skills/bio-atac-seq-atac-qc/SKILL.md +292 -0
  35. package/data/skills/bio-atac-seq-differential-accessibility/SKILL.md +268 -0
  36. package/data/skills/bio-atac-seq-footprinting/SKILL.md +256 -0
  37. package/data/skills/bio-atac-seq-motif-deviation/SKILL.md +319 -0
  38. package/data/skills/bio-atac-seq-nucleosome-positioning/SKILL.md +321 -0
  39. package/data/skills/bio-basecalling/SKILL.md +368 -0
  40. package/data/skills/bio-batch-downloads/SKILL.md +384 -0
  41. package/data/skills/bio-batch-processing/SKILL.md +303 -0
  42. package/data/skills/bio-bedgraph-handling/SKILL.md +336 -0
  43. package/data/skills/bio-blast-searches/SKILL.md +354 -0
  44. package/data/skills/bio-causal-genomics-colocalization-analysis/SKILL.md +264 -0
  45. package/data/skills/bio-causal-genomics-fine-mapping/SKILL.md +267 -0
  46. package/data/skills/bio-causal-genomics-mediation-analysis/SKILL.md +264 -0
  47. package/data/skills/bio-causal-genomics-mendelian-randomization/SKILL.md +221 -0
  48. package/data/skills/bio-causal-genomics-pleiotropy-detection/SKILL.md +292 -0
  49. package/data/skills/bio-cfdna-preprocessing/SKILL.md +200 -0
  50. package/data/skills/bio-chipseq-differential-binding/SKILL.md +262 -0
  51. package/data/skills/bio-chipseq-motif-analysis/SKILL.md +387 -0
  52. package/data/skills/bio-chipseq-peak-annotation/SKILL.md +239 -0
  53. package/data/skills/bio-chipseq-peak-calling/SKILL.md +277 -0
  54. package/data/skills/bio-chipseq-qc/SKILL.md +391 -0
  55. package/data/skills/bio-chipseq-super-enhancers/SKILL.md +288 -0
  56. package/data/skills/bio-chipseq-visualization/SKILL.md +289 -0
  57. package/data/skills/bio-clinical-databases-clinvar-lookup/SKILL.md +188 -0
  58. package/data/skills/bio-clinical-databases-dbsnp-queries/SKILL.md +171 -0
  59. package/data/skills/bio-clinical-databases-gnomad-frequencies/SKILL.md +205 -0
  60. package/data/skills/bio-clinical-databases-hla-typing/SKILL.md +248 -0
  61. package/data/skills/bio-clinical-databases-myvariant-queries/SKILL.md +174 -0
  62. package/data/skills/bio-clinical-databases-pharmacogenomics/SKILL.md +232 -0
  63. package/data/skills/bio-clinical-databases-polygenic-risk/SKILL.md +276 -0
  64. package/data/skills/bio-clinical-databases-somatic-signatures/SKILL.md +261 -0
  65. package/data/skills/bio-clinical-databases-tumor-mutational-burden/SKILL.md +301 -0
  66. package/data/skills/bio-clinical-databases-variant-prioritization/SKILL.md +225 -0
  67. package/data/skills/bio-clip-seq-binding-site-annotation/SKILL.md +66 -0
  68. package/data/skills/bio-clip-seq-clip-alignment/SKILL.md +70 -0
  69. package/data/skills/bio-clip-seq-clip-motif-analysis/SKILL.md +62 -0
  70. package/data/skills/bio-clip-seq-clip-peak-calling/SKILL.md +282 -0
  71. package/data/skills/bio-clip-seq-clip-preprocessing/SKILL.md +142 -0
  72. package/data/skills/bio-codon-usage/SKILL.md +353 -0
  73. package/data/skills/bio-comparative-genomics-ancestral-reconstruction/SKILL.md +312 -0
  74. package/data/skills/bio-comparative-genomics-hgt-detection/SKILL.md +341 -0
  75. package/data/skills/bio-comparative-genomics-ortholog-inference/SKILL.md +308 -0
  76. package/data/skills/bio-comparative-genomics-positive-selection/SKILL.md +354 -0
  77. package/data/skills/bio-comparative-genomics-synteny-analysis/SKILL.md +315 -0
  78. package/data/skills/bio-compressed-files/SKILL.md +263 -0
  79. package/data/skills/bio-consensus-sequences/SKILL.md +340 -0
  80. package/data/skills/bio-copy-number-cnv-annotation/SKILL.md +307 -0
  81. package/data/skills/bio-copy-number-cnv-visualization/SKILL.md +294 -0
  82. package/data/skills/bio-copy-number-cnvkit-analysis/SKILL.md +290 -0
  83. package/data/skills/bio-copy-number-gatk-cnv/SKILL.md +270 -0
  84. package/data/skills/bio-crispr-screens-base-editing-analysis/SKILL.md +110 -0
  85. package/data/skills/bio-crispr-screens-batch-correction/SKILL.md +316 -0
  86. package/data/skills/bio-crispr-screens-crispresso-editing/SKILL.md +205 -0
  87. package/data/skills/bio-crispr-screens-hit-calling/SKILL.md +264 -0
  88. package/data/skills/bio-crispr-screens-jacks-analysis/SKILL.md +313 -0
  89. package/data/skills/bio-crispr-screens-library-design/SKILL.md +417 -0
  90. package/data/skills/bio-crispr-screens-mageck-analysis/SKILL.md +222 -0
  91. package/data/skills/bio-crispr-screens-screen-qc/SKILL.md +243 -0
  92. package/data/skills/bio-ctdna-mutation-detection/SKILL.md +234 -0
  93. package/data/skills/bio-data-visualization-circos-plots/SKILL.md +405 -0
  94. package/data/skills/bio-data-visualization-color-palettes/SKILL.md +244 -0
  95. package/data/skills/bio-data-visualization-genome-browser-tracks/SKILL.md +328 -0
  96. package/data/skills/bio-data-visualization-genome-tracks/SKILL.md +249 -0
  97. package/data/skills/bio-data-visualization-ggplot2-fundamentals/SKILL.md +313 -0
  98. package/data/skills/bio-data-visualization-heatmaps-clustering/SKILL.md +227 -0
  99. package/data/skills/bio-data-visualization-interactive-visualization/SKILL.md +210 -0
  100. package/data/skills/bio-data-visualization-multipanel-figures/SKILL.md +274 -0
  101. package/data/skills/bio-data-visualization-specialized-omics-plots/SKILL.md +251 -0
  102. package/data/skills/bio-data-visualization-upset-plots/SKILL.md +228 -0
  103. package/data/skills/bio-data-visualization-volcano-customization/SKILL.md +233 -0
  104. package/data/skills/bio-de-deseq2-basics/SKILL.md +376 -0
  105. package/data/skills/bio-de-edger-basics/SKILL.md +418 -0
  106. package/data/skills/bio-de-results/SKILL.md +378 -0
  107. package/data/skills/bio-de-visualization/SKILL.md +408 -0
  108. package/data/skills/bio-differential-expression-batch-correction/SKILL.md +253 -0
  109. package/data/skills/bio-differential-expression-timeseries-de/SKILL.md +370 -0
  110. package/data/skills/bio-differential-splicing/SKILL.md +177 -0
  111. package/data/skills/bio-duplicate-handling/SKILL.md +292 -0
  112. package/data/skills/bio-entrez-fetch/SKILL.md +334 -0
  113. package/data/skills/bio-entrez-link/SKILL.md +325 -0
  114. package/data/skills/bio-entrez-search/SKILL.md +311 -0
  115. package/data/skills/bio-epidemiological-genomics-amr-surveillance/SKILL.md +233 -0
  116. package/data/skills/bio-epidemiological-genomics-pathogen-typing/SKILL.md +202 -0
  117. package/data/skills/bio-epidemiological-genomics-phylodynamics/SKILL.md +207 -0
  118. package/data/skills/bio-epidemiological-genomics-transmission-inference/SKILL.md +237 -0
  119. package/data/skills/bio-epidemiological-genomics-variant-surveillance/SKILL.md +237 -0
  120. package/data/skills/bio-epitranscriptomics-m6a-differential/SKILL.md +88 -0
  121. package/data/skills/bio-epitranscriptomics-m6a-peak-calling/SKILL.md +89 -0
  122. package/data/skills/bio-epitranscriptomics-m6anet-analysis/SKILL.md +101 -0
  123. package/data/skills/bio-epitranscriptomics-merip-preprocessing/SKILL.md +81 -0
  124. package/data/skills/bio-epitranscriptomics-modification-visualization/SKILL.md +98 -0
  125. package/data/skills/bio-experimental-design-batch-design/SKILL.md +110 -0
  126. package/data/skills/bio-experimental-design-multiple-testing/SKILL.md +98 -0
  127. package/data/skills/bio-experimental-design-power-analysis/SKILL.md +84 -0
  128. package/data/skills/bio-experimental-design-sample-size/SKILL.md +93 -0
  129. package/data/skills/bio-expression-matrix-counts-ingest/SKILL.md +220 -0
  130. package/data/skills/bio-expression-matrix-gene-id-mapping/SKILL.md +256 -0
  131. package/data/skills/bio-expression-matrix-metadata-joins/SKILL.md +271 -0
  132. package/data/skills/bio-expression-matrix-sparse-handling/SKILL.md +247 -0
  133. package/data/skills/bio-fastq-quality/SKILL.md +279 -0
  134. package/data/skills/bio-filter-sequences/SKILL.md +265 -0
  135. package/data/skills/bio-flow-cytometry-bead-normalization/SKILL.md +315 -0
  136. package/data/skills/bio-flow-cytometry-clustering-phenotyping/SKILL.md +237 -0
  137. package/data/skills/bio-flow-cytometry-compensation-transformation/SKILL.md +196 -0
  138. package/data/skills/bio-flow-cytometry-cytometry-qc/SKILL.md +382 -0
  139. package/data/skills/bio-flow-cytometry-differential-analysis/SKILL.md +217 -0
  140. package/data/skills/bio-flow-cytometry-doublet-detection/SKILL.md +288 -0
  141. package/data/skills/bio-flow-cytometry-fcs-handling/SKILL.md +221 -0
  142. package/data/skills/bio-flow-cytometry-gating-analysis/SKILL.md +193 -0
  143. package/data/skills/bio-format-conversion/SKILL.md +193 -0
  144. package/data/skills/bio-fragment-analysis/SKILL.md +214 -0
  145. package/data/skills/bio-gatk-variant-calling/SKILL.md +422 -0
  146. package/data/skills/bio-genome-assembly-assembly-polishing/SKILL.md +333 -0
  147. package/data/skills/bio-genome-assembly-assembly-qc/SKILL.md +344 -0
  148. package/data/skills/bio-genome-assembly-contamination-detection/SKILL.md +235 -0
  149. package/data/skills/bio-genome-assembly-hifi-assembly/SKILL.md +178 -0
  150. package/data/skills/bio-genome-assembly-long-read-assembly/SKILL.md +307 -0
  151. package/data/skills/bio-genome-assembly-metagenome-assembly/SKILL.md +227 -0
  152. package/data/skills/bio-genome-assembly-scaffolding/SKILL.md +204 -0
  153. package/data/skills/bio-genome-assembly-short-read-assembly/SKILL.md +319 -0
  154. package/data/skills/bio-genome-engineering-base-editing-design/SKILL.md +277 -0
  155. package/data/skills/bio-genome-engineering-grna-design/SKILL.md +221 -0
  156. package/data/skills/bio-genome-engineering-hdr-template-design/SKILL.md +264 -0
  157. package/data/skills/bio-genome-engineering-off-target-prediction/SKILL.md +232 -0
  158. package/data/skills/bio-genome-engineering-prime-editing-design/SKILL.md +275 -0
  159. package/data/skills/bio-genome-intervals-bed-file-basics/SKILL.md +357 -0
  160. package/data/skills/bio-genome-intervals-bigwig-tracks/SKILL.md +351 -0
  161. package/data/skills/bio-genome-intervals-coverage-analysis/SKILL.md +300 -0
  162. package/data/skills/bio-genome-intervals-gtf-gff-handling/SKILL.md +345 -0
  163. package/data/skills/bio-genome-intervals-interval-arithmetic/SKILL.md +485 -0
  164. package/data/skills/bio-genome-intervals-proximity-operations/SKILL.md +337 -0
  165. package/data/skills/bio-geo-data/SKILL.md +380 -0
  166. package/data/skills/bio-hi-c-analysis-compartment-analysis/SKILL.md +261 -0
  167. package/data/skills/bio-hi-c-analysis-contact-pairs/SKILL.md +278 -0
  168. package/data/skills/bio-hi-c-analysis-hic-data-io/SKILL.md +260 -0
  169. package/data/skills/bio-hi-c-analysis-hic-differential/SKILL.md +328 -0
  170. package/data/skills/bio-hi-c-analysis-hic-visualization/SKILL.md +297 -0
  171. package/data/skills/bio-hi-c-analysis-loop-calling/SKILL.md +284 -0
  172. package/data/skills/bio-hi-c-analysis-matrix-operations/SKILL.md +274 -0
  173. package/data/skills/bio-hi-c-analysis-tad-detection/SKILL.md +239 -0
  174. package/data/skills/bio-imaging-mass-cytometry-cell-segmentation/SKILL.md +241 -0
  175. package/data/skills/bio-imaging-mass-cytometry-data-preprocessing/SKILL.md +279 -0
  176. package/data/skills/bio-imaging-mass-cytometry-interactive-annotation/SKILL.md +304 -0
  177. package/data/skills/bio-imaging-mass-cytometry-phenotyping/SKILL.md +231 -0
  178. package/data/skills/bio-imaging-mass-cytometry-quality-metrics/SKILL.md +316 -0
  179. package/data/skills/bio-imaging-mass-cytometry-spatial-analysis/SKILL.md +246 -0
  180. package/data/skills/bio-immunoinformatics-epitope-prediction/SKILL.md +259 -0
  181. package/data/skills/bio-immunoinformatics-immunogenicity-scoring/SKILL.md +275 -0
  182. package/data/skills/bio-immunoinformatics-mhc-binding-prediction/SKILL.md +260 -0
  183. package/data/skills/bio-immunoinformatics-neoantigen-prediction/SKILL.md +277 -0
  184. package/data/skills/bio-immunoinformatics-tcr-epitope-binding/SKILL.md +257 -0
  185. package/data/skills/bio-isoform-switching/SKILL.md +192 -0
  186. package/data/skills/bio-liquid-biopsy-pipeline/SKILL.md +311 -0
  187. package/data/skills/bio-local-blast/SKILL.md +350 -0
  188. package/data/skills/bio-long-read-sequencing-clair3-variants/SKILL.md +252 -0
  189. package/data/skills/bio-long-read-sequencing-isoseq-analysis/SKILL.md +334 -0
  190. package/data/skills/bio-long-read-sequencing-nanopore-methylation/SKILL.md +110 -0
  191. package/data/skills/bio-longitudinal-monitoring/SKILL.md +271 -0
  192. package/data/skills/bio-longread-alignment/SKILL.md +193 -0
  193. package/data/skills/bio-longread-medaka/SKILL.md +176 -0
  194. package/data/skills/bio-longread-qc/SKILL.md +224 -0
  195. package/data/skills/bio-longread-structural-variants/SKILL.md +201 -0
  196. package/data/skills/bio-machine-learning-atlas-mapping/SKILL.md +139 -0
  197. package/data/skills/bio-machine-learning-biomarker-discovery/SKILL.md +157 -0
  198. package/data/skills/bio-machine-learning-model-validation/SKILL.md +148 -0
  199. package/data/skills/bio-machine-learning-omics-classifiers/SKILL.md +146 -0
  200. package/data/skills/bio-machine-learning-prediction-explanation/SKILL.md +162 -0
  201. package/data/skills/bio-machine-learning-survival-analysis/SKILL.md +176 -0
  202. package/data/skills/bio-metabolomics-lipidomics/SKILL.md +265 -0
  203. package/data/skills/bio-metabolomics-metabolite-annotation/SKILL.md +241 -0
  204. package/data/skills/bio-metabolomics-msdial-preprocessing/SKILL.md +308 -0
  205. package/data/skills/bio-metabolomics-normalization-qc/SKILL.md +283 -0
  206. package/data/skills/bio-metabolomics-pathway-mapping/SKILL.md +237 -0
  207. package/data/skills/bio-metabolomics-statistical-analysis/SKILL.md +276 -0
  208. package/data/skills/bio-metabolomics-targeted-analysis/SKILL.md +314 -0
  209. package/data/skills/bio-metabolomics-xcms-preprocessing/SKILL.md +268 -0
  210. package/data/skills/bio-metagenomics-abundance/SKILL.md +203 -0
  211. package/data/skills/bio-metagenomics-amr-detection/SKILL.md +293 -0
  212. package/data/skills/bio-metagenomics-functional-profiling/SKILL.md +252 -0
  213. package/data/skills/bio-metagenomics-kraken/SKILL.md +204 -0
  214. package/data/skills/bio-metagenomics-metaphlan/SKILL.md +214 -0
  215. package/data/skills/bio-metagenomics-strain-tracking/SKILL.md +292 -0
  216. package/data/skills/bio-metagenomics-visualization/SKILL.md +240 -0
  217. package/data/skills/bio-methylation-based-detection/SKILL.md +223 -0
  218. package/data/skills/bio-methylation-bismark-alignment/SKILL.md +195 -0
  219. package/data/skills/bio-methylation-calling/SKILL.md +200 -0
  220. package/data/skills/bio-methylation-dmr-detection/SKILL.md +211 -0
  221. package/data/skills/bio-methylation-methylkit/SKILL.md +219 -0
  222. package/data/skills/bio-microbiome-amplicon-processing/SKILL.md +137 -0
  223. package/data/skills/bio-microbiome-differential-abundance/SKILL.md +147 -0
  224. package/data/skills/bio-microbiome-diversity-analysis/SKILL.md +188 -0
  225. package/data/skills/bio-microbiome-functional-prediction/SKILL.md +153 -0
  226. package/data/skills/bio-microbiome-qiime2-workflow/SKILL.md +219 -0
  227. package/data/skills/bio-microbiome-taxonomy-assignment/SKILL.md +168 -0
  228. package/data/skills/bio-molecular-descriptors/SKILL.md +200 -0
  229. package/data/skills/bio-molecular-io/SKILL.md +188 -0
  230. package/data/skills/bio-motif-search/SKILL.md +354 -0
  231. package/data/skills/bio-multi-omics-data-harmonization/SKILL.md +228 -0
  232. package/data/skills/bio-multi-omics-mixomics-analysis/SKILL.md +221 -0
  233. package/data/skills/bio-multi-omics-mofa-integration/SKILL.md +225 -0
  234. package/data/skills/bio-multi-omics-similarity-network/SKILL.md +235 -0
  235. package/data/skills/bio-orchestrator/SKILL.md +133 -0
  236. package/data/skills/bio-paired-end-fastq/SKILL.md +334 -0
  237. package/data/skills/bio-pathway-enrichment-visualization/SKILL.md +278 -0
  238. package/data/skills/bio-pathway-go-enrichment/SKILL.md +218 -0
  239. package/data/skills/bio-pathway-gsea/SKILL.md +227 -0
  240. package/data/skills/bio-pathway-kegg-pathways/SKILL.md +234 -0
  241. package/data/skills/bio-pathway-reactome/SKILL.md +215 -0
  242. package/data/skills/bio-pathway-wikipathways/SKILL.md +255 -0
  243. package/data/skills/bio-pdb-geometric-analysis/SKILL.md +475 -0
  244. package/data/skills/bio-pdb-structure-io/SKILL.md +296 -0
  245. package/data/skills/bio-pdb-structure-modification/SKILL.md +448 -0
  246. package/data/skills/bio-pdb-structure-navigation/SKILL.md +335 -0
  247. package/data/skills/bio-phasing-imputation-genotype-imputation/SKILL.md +201 -0
  248. package/data/skills/bio-phasing-imputation-haplotype-phasing/SKILL.md +190 -0
  249. package/data/skills/bio-phasing-imputation-imputation-qc/SKILL.md +265 -0
  250. package/data/skills/bio-phasing-imputation-reference-panels/SKILL.md +203 -0
  251. package/data/skills/bio-phylo-distance-calculations/SKILL.md +307 -0
  252. package/data/skills/bio-phylo-modern-tree-inference/SKILL.md +274 -0
  253. package/data/skills/bio-phylo-tree-io/SKILL.md +252 -0
  254. package/data/skills/bio-phylo-tree-manipulation/SKILL.md +375 -0
  255. package/data/skills/bio-phylo-tree-visualization/SKILL.md +275 -0
  256. package/data/skills/bio-pileup-generation/SKILL.md +314 -0
  257. package/data/skills/bio-population-genetics-association-testing/SKILL.md +293 -0
  258. package/data/skills/bio-population-genetics-linkage-disequilibrium/SKILL.md +260 -0
  259. package/data/skills/bio-population-genetics-plink-basics/SKILL.md +338 -0
  260. package/data/skills/bio-population-genetics-population-structure/SKILL.md +352 -0
  261. package/data/skills/bio-population-genetics-scikit-allel-analysis/SKILL.md +306 -0
  262. package/data/skills/bio-population-genetics-selection-statistics/SKILL.md +251 -0
  263. package/data/skills/bio-primer-design-primer-basics/SKILL.md +289 -0
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@@ -0,0 +1,608 @@
1
+ ---
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+ name: statsmodels
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+ description: "Statistical modeling toolkit. OLS, GLM, logistic, ARIMA, time series, hypothesis tests, diagnostics, AIC/BIC, for rigorous statistical inference and econometric analysis."
4
+ ---
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+
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+ # Statsmodels: Statistical Modeling and Econometrics
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+
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+ ## Overview
9
+
10
+ Statsmodels is Python's premier library for statistical modeling, providing tools for estimation, inference, and diagnostics across a wide range of statistical methods. Apply this skill for rigorous statistical analysis, from simple linear regression to complex time series models and econometric analyses.
11
+
12
+ ## When to Use This Skill
13
+
14
+ This skill should be used when:
15
+ - Fitting regression models (OLS, WLS, GLS, quantile regression)
16
+ - Performing generalized linear modeling (logistic, Poisson, Gamma, etc.)
17
+ - Analyzing discrete outcomes (binary, multinomial, count, ordinal)
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+ - Conducting time series analysis (ARIMA, SARIMAX, VAR, forecasting)
19
+ - Running statistical tests and diagnostics
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+ - Testing model assumptions (heteroskedasticity, autocorrelation, normality)
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+ - Detecting outliers and influential observations
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+ - Comparing models (AIC/BIC, likelihood ratio tests)
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+ - Estimating causal effects
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+ - Producing publication-ready statistical tables and inference
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+
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+ ## Quick Start Guide
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+
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+ ### Linear Regression (OLS)
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+
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+ ```python
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+ import statsmodels.api as sm
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+ import numpy as np
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+ import pandas as pd
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+
35
+ # Prepare data - ALWAYS add constant for intercept
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+ X = sm.add_constant(X_data)
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+
38
+ # Fit OLS model
39
+ model = sm.OLS(y, X)
40
+ results = model.fit()
41
+
42
+ # View comprehensive results
43
+ print(results.summary())
44
+
45
+ # Key results
46
+ print(f"R-squared: {results.rsquared:.4f}")
47
+ print(f"Coefficients:\\n{results.params}")
48
+ print(f"P-values:\\n{results.pvalues}")
49
+
50
+ # Predictions with confidence intervals
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+ predictions = results.get_prediction(X_new)
52
+ pred_summary = predictions.summary_frame()
53
+ print(pred_summary) # includes mean, CI, prediction intervals
54
+
55
+ # Diagnostics
56
+ from statsmodels.stats.diagnostic import het_breuschpagan
57
+ bp_test = het_breuschpagan(results.resid, X)
58
+ print(f"Breusch-Pagan p-value: {bp_test[1]:.4f}")
59
+
60
+ # Visualize residuals
61
+ import matplotlib.pyplot as plt
62
+ plt.scatter(results.fittedvalues, results.resid)
63
+ plt.axhline(y=0, color='r', linestyle='--')
64
+ plt.xlabel('Fitted values')
65
+ plt.ylabel('Residuals')
66
+ plt.show()
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+ ```
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+
69
+ ### Logistic Regression (Binary Outcomes)
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+
71
+ ```python
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+ from statsmodels.discrete.discrete_model import Logit
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+
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+ # Add constant
75
+ X = sm.add_constant(X_data)
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+
77
+ # Fit logit model
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+ model = Logit(y_binary, X)
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+ results = model.fit()
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+
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+ print(results.summary())
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+
83
+ # Odds ratios
84
+ odds_ratios = np.exp(results.params)
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+ print("Odds ratios:\\n", odds_ratios)
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+
87
+ # Predicted probabilities
88
+ probs = results.predict(X)
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+
90
+ # Binary predictions (0.5 threshold)
91
+ predictions = (probs > 0.5).astype(int)
92
+
93
+ # Model evaluation
94
+ from sklearn.metrics import classification_report, roc_auc_score
95
+
96
+ print(classification_report(y_binary, predictions))
97
+ print(f"AUC: {roc_auc_score(y_binary, probs):.4f}")
98
+
99
+ # Marginal effects
100
+ marginal = results.get_margeff()
101
+ print(marginal.summary())
102
+ ```
103
+
104
+ ### Time Series (ARIMA)
105
+
106
+ ```python
107
+ from statsmodels.tsa.arima.model import ARIMA
108
+ from statsmodels.graphics.tsaplots import plot_acf, plot_pacf
109
+
110
+ # Check stationarity
111
+ from statsmodels.tsa.stattools import adfuller
112
+
113
+ adf_result = adfuller(y_series)
114
+ print(f"ADF p-value: {adf_result[1]:.4f}")
115
+
116
+ if adf_result[1] > 0.05:
117
+ # Series is non-stationary, difference it
118
+ y_diff = y_series.diff().dropna()
119
+
120
+ # Plot ACF/PACF to identify p, q
121
+ fig, (ax1, ax2) = plt.subplots(2, 1, figsize=(12, 8))
122
+ plot_acf(y_diff, lags=40, ax=ax1)
123
+ plot_pacf(y_diff, lags=40, ax=ax2)
124
+ plt.show()
125
+
126
+ # Fit ARIMA(p,d,q)
127
+ model = ARIMA(y_series, order=(1, 1, 1))
128
+ results = model.fit()
129
+
130
+ print(results.summary())
131
+
132
+ # Forecast
133
+ forecast = results.forecast(steps=10)
134
+ forecast_obj = results.get_forecast(steps=10)
135
+ forecast_df = forecast_obj.summary_frame()
136
+
137
+ print(forecast_df) # includes mean and confidence intervals
138
+
139
+ # Residual diagnostics
140
+ results.plot_diagnostics(figsize=(12, 8))
141
+ plt.show()
142
+ ```
143
+
144
+ ### Generalized Linear Models (GLM)
145
+
146
+ ```python
147
+ import statsmodels.api as sm
148
+
149
+ # Poisson regression for count data
150
+ X = sm.add_constant(X_data)
151
+ model = sm.GLM(y_counts, X, family=sm.families.Poisson())
152
+ results = model.fit()
153
+
154
+ print(results.summary())
155
+
156
+ # Rate ratios (for Poisson with log link)
157
+ rate_ratios = np.exp(results.params)
158
+ print("Rate ratios:\\n", rate_ratios)
159
+
160
+ # Check overdispersion
161
+ overdispersion = results.pearson_chi2 / results.df_resid
162
+ print(f"Overdispersion: {overdispersion:.2f}")
163
+
164
+ if overdispersion > 1.5:
165
+ # Use Negative Binomial instead
166
+ from statsmodels.discrete.count_model import NegativeBinomial
167
+ nb_model = NegativeBinomial(y_counts, X)
168
+ nb_results = nb_model.fit()
169
+ print(nb_results.summary())
170
+ ```
171
+
172
+ ## Core Statistical Modeling Capabilities
173
+
174
+ ### 1. Linear Regression Models
175
+
176
+ Comprehensive suite of linear models for continuous outcomes with various error structures.
177
+
178
+ **Available models:**
179
+ - **OLS**: Standard linear regression with i.i.d. errors
180
+ - **WLS**: Weighted least squares for heteroskedastic errors
181
+ - **GLS**: Generalized least squares for arbitrary covariance structure
182
+ - **GLSAR**: GLS with autoregressive errors for time series
183
+ - **Quantile Regression**: Conditional quantiles (robust to outliers)
184
+ - **Mixed Effects**: Hierarchical/multilevel models with random effects
185
+ - **Recursive/Rolling**: Time-varying parameter estimation
186
+
187
+ **Key features:**
188
+ - Comprehensive diagnostic tests
189
+ - Robust standard errors (HC, HAC, cluster-robust)
190
+ - Influence statistics (Cook's distance, leverage, DFFITS)
191
+ - Hypothesis testing (F-tests, Wald tests)
192
+ - Model comparison (AIC, BIC, likelihood ratio tests)
193
+ - Prediction with confidence and prediction intervals
194
+
195
+ **When to use:** Continuous outcome variable, want inference on coefficients, need diagnostics
196
+
197
+ **Reference:** See `references/linear_models.md` for detailed guidance on model selection, diagnostics, and best practices.
198
+
199
+ ### 2. Generalized Linear Models (GLM)
200
+
201
+ Flexible framework extending linear models to non-normal distributions.
202
+
203
+ **Distribution families:**
204
+ - **Binomial**: Binary outcomes or proportions (logistic regression)
205
+ - **Poisson**: Count data
206
+ - **Negative Binomial**: Overdispersed counts
207
+ - **Gamma**: Positive continuous, right-skewed data
208
+ - **Inverse Gaussian**: Positive continuous with specific variance structure
209
+ - **Gaussian**: Equivalent to OLS
210
+ - **Tweedie**: Flexible family for semi-continuous data
211
+
212
+ **Link functions:**
213
+ - Logit, Probit, Log, Identity, Inverse, Sqrt, CLogLog, Power
214
+ - Choose based on interpretation needs and model fit
215
+
216
+ **Key features:**
217
+ - Maximum likelihood estimation via IRLS
218
+ - Deviance and Pearson residuals
219
+ - Goodness-of-fit statistics
220
+ - Pseudo R-squared measures
221
+ - Robust standard errors
222
+
223
+ **When to use:** Non-normal outcomes, need flexible variance and link specifications
224
+
225
+ **Reference:** See `references/glm.md` for family selection, link functions, interpretation, and diagnostics.
226
+
227
+ ### 3. Discrete Choice Models
228
+
229
+ Models for categorical and count outcomes.
230
+
231
+ **Binary models:**
232
+ - **Logit**: Logistic regression (odds ratios)
233
+ - **Probit**: Probit regression (normal distribution)
234
+
235
+ **Multinomial models:**
236
+ - **MNLogit**: Unordered categories (3+ levels)
237
+ - **Conditional Logit**: Choice models with alternative-specific variables
238
+ - **Ordered Model**: Ordinal outcomes (ordered categories)
239
+
240
+ **Count models:**
241
+ - **Poisson**: Standard count model
242
+ - **Negative Binomial**: Overdispersed counts
243
+ - **Zero-Inflated**: Excess zeros (ZIP, ZINB)
244
+ - **Hurdle Models**: Two-stage models for zero-heavy data
245
+
246
+ **Key features:**
247
+ - Maximum likelihood estimation
248
+ - Marginal effects at means or average marginal effects
249
+ - Model comparison via AIC/BIC
250
+ - Predicted probabilities and classification
251
+ - Goodness-of-fit tests
252
+
253
+ **When to use:** Binary, categorical, or count outcomes
254
+
255
+ **Reference:** See `references/discrete_choice.md` for model selection, interpretation, and evaluation.
256
+
257
+ ### 4. Time Series Analysis
258
+
259
+ Comprehensive time series modeling and forecasting capabilities.
260
+
261
+ **Univariate models:**
262
+ - **AutoReg (AR)**: Autoregressive models
263
+ - **ARIMA**: Autoregressive integrated moving average
264
+ - **SARIMAX**: Seasonal ARIMA with exogenous variables
265
+ - **Exponential Smoothing**: Simple, Holt, Holt-Winters
266
+ - **ETS**: Innovations state space models
267
+
268
+ **Multivariate models:**
269
+ - **VAR**: Vector autoregression
270
+ - **VARMAX**: VAR with MA and exogenous variables
271
+ - **Dynamic Factor Models**: Extract common factors
272
+ - **VECM**: Vector error correction models (cointegration)
273
+
274
+ **Advanced models:**
275
+ - **State Space**: Kalman filtering, custom specifications
276
+ - **Regime Switching**: Markov switching models
277
+ - **ARDL**: Autoregressive distributed lag
278
+
279
+ **Key features:**
280
+ - ACF/PACF analysis for model identification
281
+ - Stationarity tests (ADF, KPSS)
282
+ - Forecasting with prediction intervals
283
+ - Residual diagnostics (Ljung-Box, heteroskedasticity)
284
+ - Granger causality testing
285
+ - Impulse response functions (IRF)
286
+ - Forecast error variance decomposition (FEVD)
287
+
288
+ **When to use:** Time-ordered data, forecasting, understanding temporal dynamics
289
+
290
+ **Reference:** See `references/time_series.md` for model selection, diagnostics, and forecasting methods.
291
+
292
+ ### 5. Statistical Tests and Diagnostics
293
+
294
+ Extensive testing and diagnostic capabilities for model validation.
295
+
296
+ **Residual diagnostics:**
297
+ - Autocorrelation tests (Ljung-Box, Durbin-Watson, Breusch-Godfrey)
298
+ - Heteroskedasticity tests (Breusch-Pagan, White, ARCH)
299
+ - Normality tests (Jarque-Bera, Omnibus, Anderson-Darling, Lilliefors)
300
+ - Specification tests (RESET, Harvey-Collier)
301
+
302
+ **Influence and outliers:**
303
+ - Leverage (hat values)
304
+ - Cook's distance
305
+ - DFFITS and DFBETAs
306
+ - Studentized residuals
307
+ - Influence plots
308
+
309
+ **Hypothesis testing:**
310
+ - t-tests (one-sample, two-sample, paired)
311
+ - Proportion tests
312
+ - Chi-square tests
313
+ - Non-parametric tests (Mann-Whitney, Wilcoxon, Kruskal-Wallis)
314
+ - ANOVA (one-way, two-way, repeated measures)
315
+
316
+ **Multiple comparisons:**
317
+ - Tukey's HSD
318
+ - Bonferroni correction
319
+ - False Discovery Rate (FDR)
320
+
321
+ **Effect sizes and power:**
322
+ - Cohen's d, eta-squared
323
+ - Power analysis for t-tests, proportions
324
+ - Sample size calculations
325
+
326
+ **Robust inference:**
327
+ - Heteroskedasticity-consistent SEs (HC0-HC3)
328
+ - HAC standard errors (Newey-West)
329
+ - Cluster-robust standard errors
330
+
331
+ **When to use:** Validating assumptions, detecting problems, ensuring robust inference
332
+
333
+ **Reference:** See `references/stats_diagnostics.md` for comprehensive testing and diagnostic procedures.
334
+
335
+ ## Formula API (R-style)
336
+
337
+ Statsmodels supports R-style formulas for intuitive model specification:
338
+
339
+ ```python
340
+ import statsmodels.formula.api as smf
341
+
342
+ # OLS with formula
343
+ results = smf.ols('y ~ x1 + x2 + x1:x2', data=df).fit()
344
+
345
+ # Categorical variables (automatic dummy coding)
346
+ results = smf.ols('y ~ x1 + C(category)', data=df).fit()
347
+
348
+ # Interactions
349
+ results = smf.ols('y ~ x1 * x2', data=df).fit() # x1 + x2 + x1:x2
350
+
351
+ # Polynomial terms
352
+ results = smf.ols('y ~ x + I(x**2)', data=df).fit()
353
+
354
+ # Logit
355
+ results = smf.logit('y ~ x1 + x2 + C(group)', data=df).fit()
356
+
357
+ # Poisson
358
+ results = smf.poisson('count ~ x1 + x2', data=df).fit()
359
+
360
+ # ARIMA (not available via formula, use regular API)
361
+ ```
362
+
363
+ ## Model Selection and Comparison
364
+
365
+ ### Information Criteria
366
+
367
+ ```python
368
+ # Compare models using AIC/BIC
369
+ models = {
370
+ 'Model 1': model1_results,
371
+ 'Model 2': model2_results,
372
+ 'Model 3': model3_results
373
+ }
374
+
375
+ comparison = pd.DataFrame({
376
+ 'AIC': {name: res.aic for name, res in models.items()},
377
+ 'BIC': {name: res.bic for name, res in models.items()},
378
+ 'Log-Likelihood': {name: res.llf for name, res in models.items()}
379
+ })
380
+
381
+ print(comparison.sort_values('AIC'))
382
+ # Lower AIC/BIC indicates better model
383
+ ```
384
+
385
+ ### Likelihood Ratio Test (Nested Models)
386
+
387
+ ```python
388
+ # For nested models (one is subset of the other)
389
+ from scipy import stats
390
+
391
+ lr_stat = 2 * (full_model.llf - reduced_model.llf)
392
+ df = full_model.df_model - reduced_model.df_model
393
+ p_value = 1 - stats.chi2.cdf(lr_stat, df)
394
+
395
+ print(f"LR statistic: {lr_stat:.4f}")
396
+ print(f"p-value: {p_value:.4f}")
397
+
398
+ if p_value < 0.05:
399
+ print("Full model significantly better")
400
+ else:
401
+ print("Reduced model preferred (parsimony)")
402
+ ```
403
+
404
+ ### Cross-Validation
405
+
406
+ ```python
407
+ from sklearn.model_selection import KFold
408
+ from sklearn.metrics import mean_squared_error
409
+
410
+ kf = KFold(n_splits=5, shuffle=True, random_state=42)
411
+ cv_scores = []
412
+
413
+ for train_idx, val_idx in kf.split(X):
414
+ X_train, X_val = X.iloc[train_idx], X.iloc[val_idx]
415
+ y_train, y_val = y.iloc[train_idx], y.iloc[val_idx]
416
+
417
+ # Fit model
418
+ model = sm.OLS(y_train, X_train).fit()
419
+
420
+ # Predict
421
+ y_pred = model.predict(X_val)
422
+
423
+ # Score
424
+ rmse = np.sqrt(mean_squared_error(y_val, y_pred))
425
+ cv_scores.append(rmse)
426
+
427
+ print(f"CV RMSE: {np.mean(cv_scores):.4f} ± {np.std(cv_scores):.4f}")
428
+ ```
429
+
430
+ ## Best Practices
431
+
432
+ ### Data Preparation
433
+
434
+ 1. **Always add constant**: Use `sm.add_constant()` unless excluding intercept
435
+ 2. **Check for missing values**: Handle or impute before fitting
436
+ 3. **Scale if needed**: Improves convergence, interpretation (but not required for tree models)
437
+ 4. **Encode categoricals**: Use formula API or manual dummy coding
438
+
439
+ ### Model Building
440
+
441
+ 1. **Start simple**: Begin with basic model, add complexity as needed
442
+ 2. **Check assumptions**: Test residuals, heteroskedasticity, autocorrelation
443
+ 3. **Use appropriate model**: Match model to outcome type (binary→Logit, count→Poisson)
444
+ 4. **Consider alternatives**: If assumptions violated, use robust methods or different model
445
+
446
+ ### Inference
447
+
448
+ 1. **Report effect sizes**: Not just p-values
449
+ 2. **Use robust SEs**: When heteroskedasticity or clustering present
450
+ 3. **Multiple comparisons**: Correct when testing many hypotheses
451
+ 4. **Confidence intervals**: Always report alongside point estimates
452
+
453
+ ### Model Evaluation
454
+
455
+ 1. **Check residuals**: Plot residuals vs fitted, Q-Q plot
456
+ 2. **Influence diagnostics**: Identify and investigate influential observations
457
+ 3. **Out-of-sample validation**: Test on holdout set or cross-validate
458
+ 4. **Compare models**: Use AIC/BIC for non-nested, LR test for nested
459
+
460
+ ### Reporting
461
+
462
+ 1. **Comprehensive summary**: Use `.summary()` for detailed output
463
+ 2. **Document decisions**: Note transformations, excluded observations
464
+ 3. **Interpret carefully**: Account for link functions (e.g., exp(β) for log link)
465
+ 4. **Visualize**: Plot predictions, confidence intervals, diagnostics
466
+
467
+ ## Common Workflows
468
+
469
+ ### Workflow 1: Linear Regression Analysis
470
+
471
+ 1. Explore data (plots, descriptives)
472
+ 2. Fit initial OLS model
473
+ 3. Check residual diagnostics
474
+ 4. Test for heteroskedasticity, autocorrelation
475
+ 5. Check for multicollinearity (VIF)
476
+ 6. Identify influential observations
477
+ 7. Refit with robust SEs if needed
478
+ 8. Interpret coefficients and inference
479
+ 9. Validate on holdout or via CV
480
+
481
+ ### Workflow 2: Binary Classification
482
+
483
+ 1. Fit logistic regression (Logit)
484
+ 2. Check for convergence issues
485
+ 3. Interpret odds ratios
486
+ 4. Calculate marginal effects
487
+ 5. Evaluate classification performance (AUC, confusion matrix)
488
+ 6. Check for influential observations
489
+ 7. Compare with alternative models (Probit)
490
+ 8. Validate predictions on test set
491
+
492
+ ### Workflow 3: Count Data Analysis
493
+
494
+ 1. Fit Poisson regression
495
+ 2. Check for overdispersion
496
+ 3. If overdispersed, fit Negative Binomial
497
+ 4. Check for excess zeros (consider ZIP/ZINB)
498
+ 5. Interpret rate ratios
499
+ 6. Assess goodness of fit
500
+ 7. Compare models via AIC
501
+ 8. Validate predictions
502
+
503
+ ### Workflow 4: Time Series Forecasting
504
+
505
+ 1. Plot series, check for trend/seasonality
506
+ 2. Test for stationarity (ADF, KPSS)
507
+ 3. Difference if non-stationary
508
+ 4. Identify p, q from ACF/PACF
509
+ 5. Fit ARIMA or SARIMAX
510
+ 6. Check residual diagnostics (Ljung-Box)
511
+ 7. Generate forecasts with confidence intervals
512
+ 8. Evaluate forecast accuracy on test set
513
+
514
+ ## Reference Documentation
515
+
516
+ This skill includes comprehensive reference files for detailed guidance:
517
+
518
+ ### references/linear_models.md
519
+ Detailed coverage of linear regression models including:
520
+ - OLS, WLS, GLS, GLSAR, Quantile Regression
521
+ - Mixed effects models
522
+ - Recursive and rolling regression
523
+ - Comprehensive diagnostics (heteroskedasticity, autocorrelation, multicollinearity)
524
+ - Influence statistics and outlier detection
525
+ - Robust standard errors (HC, HAC, cluster)
526
+ - Hypothesis testing and model comparison
527
+
528
+ ### references/glm.md
529
+ Complete guide to generalized linear models:
530
+ - All distribution families (Binomial, Poisson, Gamma, etc.)
531
+ - Link functions and when to use each
532
+ - Model fitting and interpretation
533
+ - Pseudo R-squared and goodness of fit
534
+ - Diagnostics and residual analysis
535
+ - Applications (logistic, Poisson, Gamma regression)
536
+
537
+ ### references/discrete_choice.md
538
+ Comprehensive guide to discrete outcome models:
539
+ - Binary models (Logit, Probit)
540
+ - Multinomial models (MNLogit, Conditional Logit)
541
+ - Count models (Poisson, Negative Binomial, Zero-Inflated, Hurdle)
542
+ - Ordinal models
543
+ - Marginal effects and interpretation
544
+ - Model diagnostics and comparison
545
+
546
+ ### references/time_series.md
547
+ In-depth time series analysis guidance:
548
+ - Univariate models (AR, ARIMA, SARIMAX, Exponential Smoothing)
549
+ - Multivariate models (VAR, VARMAX, Dynamic Factor)
550
+ - State space models
551
+ - Stationarity testing and diagnostics
552
+ - Forecasting methods and evaluation
553
+ - Granger causality, IRF, FEVD
554
+
555
+ ### references/stats_diagnostics.md
556
+ Comprehensive statistical testing and diagnostics:
557
+ - Residual diagnostics (autocorrelation, heteroskedasticity, normality)
558
+ - Influence and outlier detection
559
+ - Hypothesis tests (parametric and non-parametric)
560
+ - ANOVA and post-hoc tests
561
+ - Multiple comparisons correction
562
+ - Robust covariance matrices
563
+ - Power analysis and effect sizes
564
+
565
+ **When to reference:**
566
+ - Need detailed parameter explanations
567
+ - Choosing between similar models
568
+ - Troubleshooting convergence or diagnostic issues
569
+ - Understanding specific test statistics
570
+ - Looking for code examples for advanced features
571
+
572
+ **Search patterns:**
573
+ ```bash
574
+ # Find information about specific models
575
+ grep -r "Quantile Regression" references/
576
+
577
+ # Find diagnostic tests
578
+ grep -r "Breusch-Pagan" references/stats_diagnostics.md
579
+
580
+ # Find time series guidance
581
+ grep -r "SARIMAX" references/time_series.md
582
+ ```
583
+
584
+ ## Common Pitfalls to Avoid
585
+
586
+ 1. **Forgetting constant term**: Always use `sm.add_constant()` unless no intercept desired
587
+ 2. **Ignoring assumptions**: Check residuals, heteroskedasticity, autocorrelation
588
+ 3. **Wrong model for outcome type**: Binary→Logit/Probit, Count→Poisson/NB, not OLS
589
+ 4. **Not checking convergence**: Look for optimization warnings
590
+ 5. **Misinterpreting coefficients**: Remember link functions (log, logit, etc.)
591
+ 6. **Using Poisson with overdispersion**: Check dispersion, use Negative Binomial if needed
592
+ 7. **Not using robust SEs**: When heteroskedasticity or clustering present
593
+ 8. **Overfitting**: Too many parameters relative to sample size
594
+ 9. **Data leakage**: Fitting on test data or using future information
595
+ 10. **Not validating predictions**: Always check out-of-sample performance
596
+ 11. **Comparing non-nested models**: Use AIC/BIC, not LR test
597
+ 12. **Ignoring influential observations**: Check Cook's distance and leverage
598
+ 13. **Multiple testing**: Correct p-values when testing many hypotheses
599
+ 14. **Not differencing time series**: Fit ARIMA on non-stationary data
600
+ 15. **Confusing prediction vs confidence intervals**: Prediction intervals are wider
601
+
602
+ ## Getting Help
603
+
604
+ For detailed documentation and examples:
605
+ - Official docs: https://www.statsmodels.org/stable/
606
+ - User guide: https://www.statsmodels.org/stable/user-guide.html
607
+ - Examples: https://www.statsmodels.org/stable/examples/index.html
608
+ - API reference: https://www.statsmodels.org/stable/api.html