roebe 0.5.109
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- checksums.yaml +7 -0
- data/README.md +2448 -0
- data/bin/blinking_cursor +7 -0
- data/bin/browser +7 -0
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- data/bin/compare_these_two_directories +7 -0
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- data/bin/create_zip +7 -0
- data/bin/display_gcc_version +7 -0
- data/bin/do_a_google_search +7 -0
- data/bin/extract_gem_file +7 -0
- data/bin/fragment_maker +7 -0
- data/bin/generate_fstab_file +7 -0
- data/bin/hello_world +7 -0
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- data/bin/increment_application_version +7 -0
- data/bin/increment_application_version_then_push_the_gem +13 -0
- data/bin/install_all_registered_fonts +7 -0
- data/bin/install_my_addons +115 -0
- data/bin/interactive_file_creator +7 -0
- data/bin/kill_firefox +7 -0
- data/bin/kill_palemoon +7 -0
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- data/bin/replace_space_with_underscore +7 -0
- data/bin/rfirefox +7 -0
- data/bin/rinstall2 +7 -0
- data/bin/roebe +7 -0
- data/bin/roebe_documentation +7 -0
- data/bin/roebeshell +11 -0
- data/bin/ruby_cat +7 -0
- data/bin/ruby_dhcpcd +7 -0
- data/bin/run +7 -0
- data/bin/rxinitrc +7 -0
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- data/bin/show_ten_aliases +7 -0
- data/bin/simple_extractor +9 -0
- data/bin/symlink_directories_from_that_directory_to_the_current_directory +7 -0
- data/bin/symlink_everything_from_that_directory_to_this_directory +7 -0
- data/bin/symlink_files_from_that_directory_to_the_current_directory +7 -0
- data/bin/take_screenshot +7 -0
- data/bin/to_binary +7 -0
- data/bin/tokenitor +7 -0
- data/bin/trad +7 -0
- data/bin/vim_paradise +7 -0
- data/bin/wlan +7 -0
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- data/doc/PHILOSOPHY_OF_THE_ROEBE_SHELL.md +64 -0
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- data/doc/sinatra_tutorial/sinatra_tutorial.cgi +7 -0
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- data/doc/sinatra_tutorial/sinatra_tutorial.sinatra +56 -0
- data/doc/todo/TODO_FOR_THE_ROEBE_PROJECT.md +1 -0
- data/doc/todo/todo_for_the_roebe_shell.md +1216 -0
- data/lib/roebe/autoinclude.rb +4 -0
- data/lib/roebe/autoinclude_encoding.rb +11 -0
- data/lib/roebe/autoinclude_open.rb +3 -0
- data/lib/roebe/base/base.rb +25 -0
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- data/lib/roebe/base/commandline_arguments.rb +86 -0
- data/lib/roebe/base/constants.rb +25 -0
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- data/lib/roebe/base/esystem.rb +84 -0
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- data/lib/roebe/browser/output_url_then_open_in_browser.rb +168 -0
- data/lib/roebe/browser/palemoon.rb +59 -0
- data/lib/roebe/browser/reset.rb +50 -0
- data/lib/roebe/cat/cat.rb +137 -0
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- data/lib/roebe/classes/ascii/README.md +2 -0
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- data/lib/roebe/classes/convert_this_cgi_file_into_a_sinatrafied_application.rb +153 -0
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- metadata +2785 -0
@@ -0,0 +1,693 @@
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german('Aging') {
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autoextend
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main_css '
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a:link,
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text-decoration: none;
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}
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a:hover {
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colour: lightblue;
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}
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'+TEMPLATE1
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body_css_class 'mar0px s2px padt2px VERDANAs'
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body_css_style 'background-color: #d3d2d1;'
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font_size '1.1em'
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# =========================================================================== #
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# === CSS_CLASS_FOR_DATUM
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# =========================================================================== #
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CSS_CLASS_FOR_DATUM = 'BG_Black gold pad0_5em wid25'
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doc('mar0px pad0px s0_6em wid97') {
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dimg 'science/aging/AGING_LOGO.png',
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div('wid100 table_display') {
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# =================================================================== #
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# === Gedicht von Goethe
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# =================================================================== #
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h3 'Das Alter'
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p('larger marl2em') {
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lembre "„Das Alter ist ein höflich' Mann:"
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lembre "Einmal übers andre klopft er an."
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lembre "Aber nun sagt niemand: Herein!"
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lembre "Da klinkt er auf, tritt ein so schnell,"
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lembre "Und nun heißt's, er sei ein grober Gesell.“"
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br
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italic '- Johann Wolfgang von Goethe',
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'mars5em'
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}
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}
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div('table_cell') {
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# =================================================================== #
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# === Gedicht von Annie Besant, 1886
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# =================================================================== #
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# Siehe: https://en.wikisource.org/wiki/Life,_Death,_and_Immortality
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# =================================================================== #
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h3 'LIFE, DEATH, AND IMMORTALITY.'
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+
p('larger marl2em') {
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+
lembre "„Out of the darkness of the womb, into the darkness of the grave.:"
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lembre "man passes across his narrow strip of life. Two vast"
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lembre "eternities stretch oceanlike on either side of the"
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lembre "island of individual exisence, and through"
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lembre "the darkness that enshrouds them no"
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lembre "human eye, it has been thought,"
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lembre "could ever pierce."
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br
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italic '- Annie Besant, 1886',
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'mars5em'
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}
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}
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}
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}
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div {
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embed_and_drag_remote_image 'https://i.imgur.com/mX9CGCf.jpg',
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'bblack2',
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'drag_forgot_about_getting_older'
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embed_and_drag_remote_image 'https://i.imgur.com/1L1VJPB.jpg',
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'bblack2 marl1em',
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'drag_growing_old'
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embed_and_drag_remote_image 'https://i.imgur.com/Xazgapm.jpg',
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'bblack2 marl1em',
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'drag_old_woman_has_difficulties_crossing_the_street'
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}
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# ========================================================================= #
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# === How mankind responded to death
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# ========================================================================= #
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div_default {
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e 'Mankind responded to their physical vulnerabilities, death
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+
and aging <b>by developing concepts such as life after death</b>,
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+
in order to soften the harsh reality that comes with death.'
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br
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e 'In utopian worlds, such as portrayed in <i>science fiction</i>,
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life often exists without disease, disability or death. Places
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on earth where paradise exists and reigns.'
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br
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e 'The usual goal, already seen in the Babylonian legend about
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Gilgamesh and Enkidu, was to attain eternal youth and
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+
immortality.'
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+
}
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+
# ========================================================================= #
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# === Fakten und Daten zum Altern
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# ========================================================================= #
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h2 'Fakten und Daten zum Altern:'
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div_default {
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e '- Die meisten Menschen scheinen ähnlich zu altern, wie bei einem
|
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+
"<b>Entwicklungsprozess</b>". Dies muss zwar kein eigentlicher
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+
Entwicklungsprozess sein, aber zumindest gibt es Ähnlichkeiten
|
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+
beim Alterungsprozess zwischen verschiedenen Menschen. Es gibt
|
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+
keinen Menschen der, a priori, nicht altert. Lediglich die
|
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+
Geschwindigkeit und Unterschiede bei diesem Vorgang sind
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+
gegeben.'
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+
br
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le '<b>Sarkopenie</b> kommt sowohl bei Menschen als auch bei
|
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+
Fadenwürmern statt. Es handelt sich hier um den Verlust von
|
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+
Muskeln und Körperkraft.'
|
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+
}
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+
# ========================================================================= #
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+
# === Jeanne Calment
|
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+
# ========================================================================= #
|
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div_default {
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e 'Jeanne Calment wurde (angeblich) 122 Jahre alt.'
|
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+
}
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+
# ========================================================================= #
|
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+
# === datum: 14.04.2022
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+
#
|
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+
# Hautzellen einer 53-jährigen Frau um 30 Jahre verjüngt.
|
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+
# ========================================================================= #
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+
datum '14.04.2022', CSS_CLASS_FOR_DATUM
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div_default {
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+
boldbr 'Hautzellen einer 53-jährigen Frau um 30 Jahre verjüngt'
|
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+
br
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e 'Einem Team des renommierten Babraham Institute im englischen
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Cambridge ist es gelungen, den Alterungsprozess von Hautzellen
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+
einer über 50-jährigen Person um rund 30 Jahre zu verjüngen.'
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+
br
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e "Wie hat es das Team um den aus Deutschland stammenden
|
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+
Epigenetikspezialisten Wolf Reik geschafft, die biologische
|
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+
Uhr der Hautzellen zurückzudrehen? Die Forscherinnen und
|
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+
Forscher haben dafür vor allem jene Erkenntnisse
|
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+
weiterentwickelt, für die der japanische Mediziner
|
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+
Shin'ya Yamanaka 2012 gemeinsam mit John Gurdon
|
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+
mit dem Medizinnobelpreis ausgezeichnet worden war."
|
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+
br
|
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+
e 'Yamanaka war es zuvor gelungen, entwickelte Bindegewebszellen
|
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+
von Mäusen in sogenannte induzierte pluripotente Stammzellen
|
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+
(iPS) zurückzuverwandeln. Diese sogenannte Reprogrammierung
|
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+
wird durch eine Kombination aus vier Genen erzeugt
|
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+
beziehungsweise induziert, den sogenannten Yamanaka-Faktoren.
|
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+
Bei diesem Prozess, der 50 Tage lang dauert, werden nach
|
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+
und nach die Merkmale der ausdifferenzierten Zellen
|
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+
gelöscht, und ihr ursprünglicher Status wird
|
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+
wiederhergestellt. Die solcherart rückverwandelten
|
150
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+
Zellen können sich in alle möglichen Zelltypen
|
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+
weiterentwickeln – nichts anderes bedeutet pluripotent.'
|
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+
br
|
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e 'Die neue Methode des Teams um Reik umging das Problem
|
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+
der vollständigen Löschung der Zellidentität. Die
|
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|
+
Reprogrammierung wurde nämlich bereits nach 13
|
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+
Tagen gestoppt. Auf diese Weise wurde zwar einerseits
|
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+
die Altersuhr der Zellen zurückgedreht, andererseits
|
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|
+
blieb ihre spezialisierte Zellfunktion erhalten.
|
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+
Die Hautzellen einer 53-Jährigen Frau blieben also
|
160
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+
Hautzellen, doch diese hatten die Eigenschaften
|
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|
+
von Hautzellen einer 20-Jährigen, wie Genomanalysen
|
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|
+
zeigten.'
|
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+
br
|
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e 'Auch die Kollagenproduktion in den umprogrammierten
|
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+
Zellen erreichte wieder ihr jugendliches Ausmaß. Und
|
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|
+
Experimente, bei denen in der Petrischale eine Wunde
|
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|
+
simuliert wurde, bestätigten ebenfalls die
|
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|
+
Verjüngung: Die reprogrammierten Hautzellen
|
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|
+
führten zu einem schnelleren Heilungsprozess.
|
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|
+
Zudem zeigte sich, dass die Methode auch
|
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|
+
günstige Auswirkungen auf Gene hatte, die
|
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|
+
mit altersbedingten Krankheiten wie Alzheimer
|
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|
+
und dem Grauen Star in Verbindung stehen.'
|
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|
+
br
|
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|
+
abr_self 'https://www.derstandard.at/story/2000134909845/hautzellen-einer-53-jaehrigen-frau-um-30-jahre-verjuengt'
|
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+
}
|
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|
+
# ========================================================================= #
|
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|
+
# === datum: 24.12.2009
|
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+
# ========================================================================= #
|
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|
+
datum '24.12.2009', CSS_CLASS_FOR_DATUM
|
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+
div_default {
|
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e 'Rüstige Altersrekordhalterin: Das Gorilla-Weibchen "Colo"
|
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|
+
ist 53 Jahre alt geworden, und damit der älteste in
|
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|
+
Gefangenschaft lebende Gorilla weltweit.'
|
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|
+
br
|
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|
+
abr_self 'https://en.wikipedia.org/wiki/Colo_%28gorilla%29'
|
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|
+
}
|
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|
+
# ========================================================================= #
|
189
|
+
# === datum: 04.04.2009
|
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|
+
#
|
191
|
+
# Von APA/dpa.
|
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|
+
# ========================================================================= #
|
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|
+
datum '04.04.2009', CSS_CLASS_FOR_DATUM
|
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+
div_default {
|
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|
+
e '<b>Herzzellen</b> erneuern sich doch.'
|
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|
+
br
|
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e 'Schwedische Forscher zogen radioaktives Isotop als "Marker" zur
|
198
|
+
Altersbestimmung von Zellen heran'
|
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|
+
br
|
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+
e 'Stockholm/Washington - Entgegen bisherigen Annahmen bildet der
|
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|
+
Mensch im Lauf seines Lebens doch neue Herzzellen, allerdings
|
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|
+
nur in begrenztem Maß. Das kann nach einer neuen Untersuchung
|
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|
+
von Forschern des Karolinska-Institutes in Stockholm als
|
204
|
+
"endgültig geklärt" angesehen werden, schreiben die Forscher
|
205
|
+
im US-Fachjournal "Science" (Bd. 324, S. 98-102).'
|
206
|
+
br
|
207
|
+
e 'Der Kardiologe Olaf Bergmann und seine Kollegen nutzten für
|
208
|
+
ihre Untersuchung die weltweite radioaktive Verseuchung nach
|
209
|
+
einer der schlimmsten Umweltkatastrophen der letzten hundert
|
210
|
+
Jahre: Atombombentests in der Atmosphäre während des
|
211
|
+
Kalten Krieges haben das radioaktive Isotop Kohlenstoff-14
|
212
|
+
freigesetzt und Spuren davon in menschlichen Zellen
|
213
|
+
hinterlassen.'
|
214
|
+
br
|
215
|
+
e 'Nach dem Verbot und Ende der oberirdischen Atombombentests
|
216
|
+
1963 wurde kein neues Kohlenstoff-14 mehr freigesetzt,
|
217
|
+
die vorhandene Menge in der menschlichen DNA verminderte
|
218
|
+
sich langsam mit einer genau berechenbaren Geschwindigkeit.'
|
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|
+
br
|
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|
+
e 'Auf dieser Grundlage konnten die Forscher den Isotopen-Anteil
|
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|
+
als "Marker" zur Altersbestimmung der Herzzellen von Menschen
|
222
|
+
nutzen, die entweder vor oder nach den Atomtests auf die Welt
|
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|
+
gekommen waren.'
|
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|
+
br
|
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|
+
e 'Dabei fanden die Forscher heraus, dass sich die Herzzellen
|
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|
+
über eine Lebensspanne langsam erneuern können. Im Alter von
|
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|
+
25 Jahren beträgt die jährliche Regeneration demnach ein
|
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|
+
Prozent. Bis zum 75. Lebensjahr sinkt sie auf 0,45 Prozent
|
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|
+
pro Jahr. Insgesamt werden der Studie zufolge innerhalb
|
230
|
+
eines normalen menschlichen Lebens weniger als die Hälfte
|
231
|
+
aller Herzzellen erneuert. Dieses Faktum solle "therapeutisch
|
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|
+
genutzt werden", meinten die Forscher.'
|
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|
+
}
|
234
|
+
# ========================================================================= #
|
235
|
+
# === datum: 03.02.2009
|
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|
+
# ========================================================================= #
|
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|
+
datum 'datum: 03.02.2009', CSS_CLASS_FOR_DATUM
|
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|
+
div_default {
|
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|
+
e 'Auch bei Europäern bestätigt: das Langlebigkeits-Gen.'
|
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|
+
br
|
241
|
+
e 'Kieler Wissenschafter untersuchten 388 Personen über 100
|
242
|
+
und fanden auffällig oft eine Variation in dem Gen FOXO3A'
|
243
|
+
br
|
244
|
+
e 'Kiel/Washington - In den 90er Jahren hatten Wissenschafter ein
|
245
|
+
Gen bei einem Wurm und einer Fliege entdeckt, das - so
|
246
|
+
die Vermutung - für deren Langlebigkeit zumindest mitverantwortlich
|
247
|
+
ist. Im September 2008 konnten US-amerikanische Forscher
|
248
|
+
dieses Gen auch bei sehr alten amerikanischen Männern
|
249
|
+
japanischer Herkunft nachweisen. Nun gelang dasselbe bei
|
250
|
+
greisen Europäern. Die Wissenschafter sprechen von
|
251
|
+
einer weiteren Bestätigung dafür, dass ein hohes Alter auch
|
252
|
+
genetisch bedingt sein kann.'
|
253
|
+
br
|
254
|
+
e 'Wie Forscher von der Universität Kiel nachwiesen tritt
|
255
|
+
eine Variation in dem Gen FOXO3A auffällig oft bei Menschen
|
256
|
+
über 100 Jahren auf und beeinflusst damit vermutlich weltweit
|
257
|
+
positiv die Lebenserwartung. Das Team rund um Stefan
|
258
|
+
Schreiber hatte bei seinen Untersuchungen DNA-Proben
|
259
|
+
von 388 hundertjährigen Deutschen mit 731 jüngeren Menschen
|
260
|
+
verglichen.'
|
261
|
+
br
|
262
|
+
e 'Mit der deutschen Stichprobe und mit zusätzlichen
|
263
|
+
Untersuchungen in Frankreich sei der Zusammenhang zwischen
|
264
|
+
FOXO3A und Langlebigkeit nunmehr bestätigt und auch für
|
265
|
+
Frauen festgestellt worden, schreiben die Forscher in den
|
266
|
+
"Proceedings" der US-Akademie der Wissenschaften.'
|
267
|
+
br
|
268
|
+
e 'Dieser Befund sei von besonderer Bedeutung, weil Japaner
|
269
|
+
und Europäer genetisch relativ unterschiedlich sind, erläuterte
|
270
|
+
die Leiterin der Kieler Forschungsgruppe "Gesundes Altern",
|
271
|
+
Almut Nebel. "Jetzt können wir davon ausgehen, dass
|
272
|
+
dieses Gen für das Erreichen eines hohen Alters wahrscheinlich
|
273
|
+
weltweit eine Rolle spielt."'
|
274
|
+
br
|
275
|
+
e '"Am schwierigsten ist es, für solch eine Studie hochbejahrte
|
276
|
+
Teilnehmer zu gewinnen, insbesondere 100-Jährige. Interessanterweise
|
277
|
+
sind die genetischen Effekte bei 100- jährigen Menschen deutlicher
|
278
|
+
zu sehen als bei 90-jährigen", schilderte Friederike Flachsbart
|
279
|
+
vom Institut für Klinische Molekularbiologie der Universität Kiel.'
|
280
|
+
br
|
281
|
+
e 'Mit Unterstützung der schleswig-holsteinischen Biodatenbank
|
282
|
+
Popgen, die zurzeit mehr als 660 Erbgutproben von 100-Jährigen
|
283
|
+
enthält, kann das Institut auf eine der weltweit größten
|
284
|
+
DNA-Sammlungen sehr alter Probanden zugreifen. (APA)'
|
285
|
+
}
|
286
|
+
# ========================================================================= #
|
287
|
+
# === datum: 30.01.2009
|
288
|
+
# ========================================================================= #
|
289
|
+
datum '30.01.2009', CSS_CLASS_FOR_DATUM
|
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|
+
div_default {
|
291
|
+
boldbr 'Kalorienreduktion verbessert Gedächtnis'
|
292
|
+
br
|
293
|
+
e 'Ergebnisse aus Tierversuchen bei älteren Menschen bestätigt'
|
294
|
+
br
|
295
|
+
e 'Washington - Eine eingeschränkte Kalorienzufuhr kann bei
|
296
|
+
älteren Menschen das Gedächtnis bessern. Eine Studie der
|
297
|
+
Universität Münster bestätigt damit Ergebnisse aus Tierversuchen
|
298
|
+
erstmals auch am Menschen.'
|
299
|
+
br
|
300
|
+
e 'Die Neurologen um Veronica Witte teilten 50 Menschen im
|
301
|
+
Alter um 60 Jahre in drei Gruppen ein. Bei den Personen der
|
302
|
+
ersten Gruppe schränkten sie die Kalorienaufnahme um etwa 30
|
303
|
+
Prozent ein. In der zweiten Gruppe erhöhten sie die Aufnahme
|
304
|
+
von ungesättigten Fettsäuren, wie sie etwa in Olivenöl
|
305
|
+
oder Fisch vorkommen, um 20 Prozent. Die übrigen Teilnehmer
|
306
|
+
dienten als Kontrollgruppe.'
|
307
|
+
br
|
308
|
+
e 'Nach drei Monaten stellten die Forscher bei jenen Menschen,
|
309
|
+
die weniger Kalorien aufgenommen hatten, ein besseres Wortgedächtnis
|
310
|
+
fest.'
|
311
|
+
br
|
312
|
+
e 'Damit einher gingen geringere Insulinwerte und geringere Mengen
|
313
|
+
eines Proteins, das auf Entzündungen hinweist. Möglicherweise seien
|
314
|
+
Entzündungsstoffe und hohe Insulinkonzentrationen am Abbau des
|
315
|
+
Gedächtnisses im Alter beteiligt, schreiben die Forscher im
|
316
|
+
Fachblatt "Proceedings of the National Academy of Sciences"'
|
317
|
+
}
|
318
|
+
# ========================================================================= #
|
319
|
+
# === datum: 31.12.2008
|
320
|
+
# ========================================================================= #
|
321
|
+
datum '31.12.2008', CSS_CLASS_FOR_DATUM
|
322
|
+
div_default {
|
323
|
+
e "It's almost New Year's Eve, a time for plunging into boisterous
|
324
|
+
crowds bathed in loud music. And for some of us, that means turning
|
325
|
+
to an old friend and hearing things like this:"
|
326
|
+
br
|
327
|
+
e '"Did you know (BOOM-da-da-BOOM) went over (Bob! You look
|
328
|
+
wonder- ) so she said (clink-clink) and then I (Here, have
|
329
|
+
another one) what would you do?"'
|
330
|
+
br
|
331
|
+
e "Too noisy to hear! But wait - how come these younger people
|
332
|
+
understood what she said? What's wrong with your ears?"
|
333
|
+
br
|
334
|
+
e 'Actually, part of the problem might be your brain.'
|
335
|
+
br
|
336
|
+
e "It might lie in your brain's dimmer switch for controlling the
|
337
|
+
input from your ears."
|
338
|
+
br
|
339
|
+
e 'That bit of brain circuitry appears to falter with age, and
|
340
|
+
scientists are getting some clues about why. If you have trouble
|
341
|
+
understanding conversation in a noisy room, you are experiencing
|
342
|
+
what is sometimes called the cocktail party problem.'
|
343
|
+
br
|
344
|
+
e 'That can be one of the first signs of an age-related hearing loss --
|
345
|
+
a more general problem that can creep in during middle age and affects
|
346
|
+
one-third of adults ages 65 to 75.'
|
347
|
+
br
|
348
|
+
e 'Scientists are still trying to piece together why our hearing
|
349
|
+
goes downhill with age, with the goal of trying to slow it or
|
350
|
+
even reverse it.'
|
351
|
+
br
|
352
|
+
e "When it comes to the cocktail party problem, the dimmer
|
353
|
+
switch is a piece of that story, though it's not clear
|
354
|
+
just how big a factor."
|
355
|
+
br
|
356
|
+
e '"I think it is a significant player," said Robert Frisina of
|
357
|
+
the University of Rochester in New York.'
|
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|
+
br
|
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|
+
e 'Scientists have long known that the brain not only receives
|
360
|
+
signals from the ears but can also talk back to them. When
|
361
|
+
there is too much noise, this dimmer-switch brain circuitry
|
362
|
+
tells the ears to reduce their flow of signals to the brain.'
|
363
|
+
br
|
364
|
+
e 'This helps the sensitive auditory system handle loud sounds
|
365
|
+
that otherwise would overwhelm it and become distorted, as when
|
366
|
+
a radio is turned up too loud for the speaker to handle. The
|
367
|
+
dimmer switch probably can block out distracting background
|
368
|
+
noise more than it does speech, Frisina said.'
|
369
|
+
br
|
370
|
+
e 'Frisina and colleagues published evidence in 2002 that the
|
371
|
+
dimmer switch effectiveness declines with age.'
|
372
|
+
br
|
373
|
+
e "Then they showed the same thing happens in mice, which meant
|
374
|
+
they could study those animals to get clues to what's going on
|
375
|
+
in people. Last year, they found a possible cause in mice for
|
376
|
+
the decline:"
|
377
|
+
br
|
378
|
+
e 'reduced supplies of a key structure on the surfaces of the
|
379
|
+
nerve cells in the dimmer-switch circuitry.'
|
380
|
+
br
|
381
|
+
e 'There is some evidence that shortcomings in this wiring
|
382
|
+
harm the inner ear as well, he said.'
|
383
|
+
br
|
384
|
+
e 'The inner ear is where sound is converted to nerve signals
|
385
|
+
using delicate hairs to detect sound waves. These hair
|
386
|
+
cells can be damaged by aging and by long hours in loud
|
387
|
+
environments.'
|
388
|
+
br
|
389
|
+
e 'The Problem?'
|
390
|
+
br
|
391
|
+
e "The brain not only receives signals from the ears but can
|
392
|
+
also talk back to them. When there's too much noise, this
|
393
|
+
dimmer-switch brain circuitry tells the ears to reduce
|
394
|
+
their flow of signals to the brain. This helps the sensitive
|
395
|
+
auditory system handle loud sounds that otherwise would
|
396
|
+
overwhelm it. That bit of brain circuitry appears to falter
|
397
|
+
with age."
|
398
|
+
}
|
399
|
+
# ========================================================================= #
|
400
|
+
# === datum: 15.07.2008
|
401
|
+
# ========================================================================= #
|
402
|
+
datum '15.07.2008', CSS_CLASS_FOR_DATUM
|
403
|
+
div_default {
|
404
|
+
e 'Die deutsche Zeitschrift "Bild der Wissenschaft" berichtet
|
405
|
+
in ihrer August-Ausgabe, dass Sport das Altern hinauszögern
|
406
|
+
kann.'
|
407
|
+
br
|
408
|
+
e "Die Forscher um Lynn Cherkas vom Londoner King's College
|
409
|
+
stellten demnach im Erbgut der durchschnittlich 49 Jahre
|
410
|
+
alten Geschwister je nach körperlicher Aktivität deutliche
|
411
|
+
Unterschiede fest."
|
412
|
+
br
|
413
|
+
e 'So waren die Endstücke der Chromosomen, die sogenannten
|
414
|
+
Telomere, bei sportlich aktiven Zwillingen um etwa 200
|
415
|
+
DNA-Bausteine (Basenpaare) länger als bei genetisch
|
416
|
+
identischen Bewegungsmuffeln.'
|
417
|
+
br
|
418
|
+
e 'Die Molekularbiologen konnten den Prozess der frühzeitigen
|
419
|
+
DNA-Rückbildung im Labor verfolgen. Dabei untersuchten sie
|
420
|
+
die Länge der Telomere, die sich bei jeder Zellteilung um
|
421
|
+
rund 20 Basenpaare verkürzen. Bei sportbegeisterten Zwillingen
|
422
|
+
schritt die Abnutzung dieser Molekül-Abschnitte langsamer
|
423
|
+
voran.'
|
424
|
+
br
|
425
|
+
e 'Damit sind körperlich fitte Menschen nach Ansicht der Autoren
|
426
|
+
nicht nur weniger anfällig für Übergewicht, Herzkrankheiten
|
427
|
+
und Diabetes, sondern scheinen auch besser vor vorschnellem
|
428
|
+
Altern geschützt zu sein als Nicht-Sportler.'
|
429
|
+
}
|
430
|
+
# ========================================================================= #
|
431
|
+
# === datum: 20.11.2003
|
432
|
+
# ========================================================================= #
|
433
|
+
datum 'datum: 20.11.2003', CSS_CLASS_FOR_DATUM
|
434
|
+
div_default {
|
435
|
+
e 'Kakerlaken überleben zwar so ziemlich alle Katastrophen, aber
|
436
|
+
als Greise bauen sie ab und werden tatterig und fußlahm. Die
|
437
|
+
Gelenke rosten ein, bei Steigungen kommen die Küchenschaben
|
438
|
+
schnell aus der Puste, fanden amerikanische Forscher heraus.'
|
439
|
+
br
|
440
|
+
e 'Haben sie erst einmal das für sie biblische Alter von 60 Wochen
|
441
|
+
erreicht, rosten ihre Gelenke ein, sie beginnen zu stolpern und
|
442
|
+
kommen kaum noch eine Steigung hoch. Auch meiden sie das Flanieren
|
443
|
+
auf offener, ungeschützter Fläche, fanden Angela Ridgel und
|
444
|
+
Kollegen von der Case Western Reserve University in Cleveland (Ohio)
|
445
|
+
nach einem Bericht des Fachmagazins "New Scientist"
|
446
|
+
(Nr. 2422, S. 20) heraus.'
|
447
|
+
br
|
448
|
+
e 'Die Biologen setzten die alternden Küchenschaben der Art Blaberus
|
449
|
+
discoidalis zum Test auf ein Mini-Laufband und stellten fest, dass sie
|
450
|
+
nur noch halb so viele Schritte machten "wie einst im Mai", also
|
451
|
+
im Vergleich zu einwöchigen jungen Kakerlaken-Hüpfern. Zudem traten
|
452
|
+
die Oldtimer sich alle paar Schritte auf die eigenen Füße. Auch eine
|
453
|
+
45 prozentige Steigung schaffte nur noch knapp die Hälfte von ihnen.'
|
454
|
+
br
|
455
|
+
e 'Die Originalarbeit ist im "Journal of Experimental Biology"
|
456
|
+
(Bd. 206, S. 4453) veröffentlicht.'
|
457
|
+
br
|
458
|
+
abr_self 'https://www.rp-online.de/wissen/wiss-leben/auch-kakerlaken-leiden-an-altersschwaeche-1.2283677'
|
459
|
+
}
|
460
|
+
# ========================================================================= #
|
461
|
+
# === 30.05.2001
|
462
|
+
# ========================================================================= #
|
463
|
+
datum '30.05.2001', CSS_CLASS_FOR_DATUM
|
464
|
+
div_default {
|
465
|
+
e 'Frauen mit breiten Hüften leben länger.'
|
466
|
+
br
|
467
|
+
e 'Frauen mit breiten Hüften leben nach einer schwedischen Studie länger
|
468
|
+
und bleiben gesünder als schmale Frauen. So sei das Risiko für Diabetes,
|
469
|
+
Herzinfarkt und anderen Herz-Kreislauf-Erkrankungen bei Frauen mit
|
470
|
+
schmalen Hüften höher, berichtete die Zeitung Göteborgs-Posten am
|
471
|
+
Dienstag.'
|
472
|
+
br
|
473
|
+
e 'Die Medizinerin Laureen Lissner hatte Gesundheit und Sterblichkeit
|
474
|
+
von 1.462 Frauen aus Göteborg untersucht. "Die Faktoren, die die
|
475
|
+
Gesundheit bei Frauen mit breiten Hüften begünstigen, sind noch nicht
|
476
|
+
ganz verstanden", räumte die Forscherin ein.'
|
477
|
+
br
|
478
|
+
e 'Frühere Studien hätten gezeigt, dass dickere Frauen und Männer
|
479
|
+
früher krank würden, betonte die Forscherin. Der <b>Hüftumfang</b>
|
480
|
+
sei dagegen bislang zu wenig beachtet worden.'
|
481
|
+
br
|
482
|
+
e 'Lissner und ihr Team hatten die untersuchten Frauen nach ihrer
|
483
|
+
Hüftbreite in vier Gruppen aufgeteilt und dabei Raucherinnen,
|
484
|
+
Ältere und Jüngere sowie Dicke und Dünne gleichmäßig verteilt,
|
485
|
+
so dass diese Eigenschaften die Ergebnisse nicht verfälschten.
|
486
|
+
Sowohl bei Krankheiten als auch bei den krankheitsbedingten
|
487
|
+
Todesfällen ergaben sich erhebliche Unterschiede je nach
|
488
|
+
Hüftumfang.'
|
489
|
+
}
|
490
|
+
# ====================================================================== #
|
491
|
+
# === Argumente pro und kontra verschiedener Aging Theories.
|
492
|
+
# ====================================================================== #
|
493
|
+
div_default {
|
494
|
+
h2 'Argumente pro und kontra verschiedener Aging Theories:',
|
495
|
+
'marb1em'
|
496
|
+
e 'Telomeres Pro:'
|
497
|
+
br
|
498
|
+
lembre '- Explanations are extremely simple based on telomeres getting shorter.'
|
499
|
+
lembre '- Werner Syndrom (mutation in WRN gene which plays a role in telomeres)'
|
500
|
+
lembre '- Gene silencing effects of shorter telomeres.'
|
501
|
+
lembre '- Diversity of aging as a process (showing multiple, diverse effects)'
|
502
|
+
lembre '- progeria (instable nuclear lamina, shows similar results to Werner syndrome)'
|
503
|
+
lembre '- cancer cells often (85%) have an active telomerase'
|
504
|
+
lembre '- zoe cells have an active telomerase while soma cells dont'
|
505
|
+
lembre '- calorie reduction will slow down cell-cycle (because less nutritions
|
506
|
+
and energy are available to warrant a new mitosis) and slower cell
|
507
|
+
cycle also means that telomeres wont be shortened as often (since they
|
508
|
+
shorten only after a round of replication)'
|
509
|
+
lembre '- People with thicker bones/waist live slightly longer. This may be
|
510
|
+
explained partially because they have a bigger pool of available
|
511
|
+
stem cells.'
|
512
|
+
lembre '- Cells that are in G0 resting phase of the cell cycle can be
|
513
|
+
generated from G1 cells by putting these G1-cells into medium which
|
514
|
+
do not contain nutritial value.'
|
515
|
+
br
|
516
|
+
e 'Things that yet have to be explained:'
|
517
|
+
br
|
518
|
+
e '- People that are thick often die earlier than people who
|
519
|
+
are slim.'
|
520
|
+
br
|
521
|
+
e 'Other "facts" or important questions'
|
522
|
+
br
|
523
|
+
lembre ' - Somatic cells sometimes express telomerase. Cancer
|
524
|
+
cells are MUCH more likely to express telomerase, thus making
|
525
|
+
telomerase a "cancer marker".'
|
526
|
+
br
|
527
|
+
lem ' - If we get DNA from a human being, can we somehow
|
528
|
+
determine from this DNA alone how old someone is? What if we
|
529
|
+
replace all the DNA of a human being?'
|
530
|
+
}
|
531
|
+
# ====================================================================== #
|
532
|
+
# === Slogans
|
533
|
+
# ====================================================================== #
|
534
|
+
h3 'Slogans',
|
535
|
+
'mart4px'
|
536
|
+
p('mars1em') {
|
537
|
+
e 'Die rate of living theory ist ein Argument für "biochemical
|
538
|
+
imperfection".'
|
539
|
+
br
|
540
|
+
e 'The ancient pharaohs took every means available to ensure
|
541
|
+
their own vestigial future persistence through the
|
542
|
+
ages.'
|
543
|
+
br
|
544
|
+
e 'Jeder Fünfte stirbt an den Folgen des Konsums von Tabak und
|
545
|
+
Alkohol.'
|
546
|
+
br
|
547
|
+
e 'Lebewesen mit einem großen Hirngewicht leben länger. Von dieser
|
548
|
+
Regel scheint es, anders als bei der Körpergewichtsregel nur
|
549
|
+
wenige Ausnahmen zu geben.'
|
550
|
+
br
|
551
|
+
e 'Genetic studies of Okinawan centenarians have shown that while
|
552
|
+
there is some genetic protection that helps the Okinawans live
|
553
|
+
to extreme ages, most of the "successful aging" phenomenon
|
554
|
+
is due to lifestyle.'
|
555
|
+
br
|
556
|
+
e 'Cells from long-lived animals are generally better at maintaining
|
557
|
+
themselves and their DNA.'
|
558
|
+
br
|
559
|
+
e 'One goal in aging is to identify the genetic determinants of
|
560
|
+
(human) longevity.'
|
561
|
+
br
|
562
|
+
e 'An der Universität von Colorado enstanden durch Mutation eines
|
563
|
+
einzigen Gens (age-1) Fadenwürmer, die eine etwa 70% höhere
|
564
|
+
Lebensdauer hatten.'
|
565
|
+
br
|
566
|
+
e 'Young Today - Old Tomorrow. Take Care of the Elderly.'
|
567
|
+
br
|
568
|
+
e 'Most modern diseases are caused by aging.'
|
569
|
+
br
|
570
|
+
e 'Although West African gerontocracies are generally
|
571
|
+
male-dominated, old women also enjoy enhanced social
|
572
|
+
status.'
|
573
|
+
br
|
574
|
+
e 'Die lebensverlängernde Wirkung der Mutation von Indy
|
575
|
+
wird durch eine Reduktion der Genaktivität erreicht.'
|
576
|
+
br
|
577
|
+
e 'Bei Fruchtfliegen führt eine Diät zu einem längeren Leben,
|
578
|
+
bei gleichzeitig stattfindender, verringerter Fruchtbarkeit.'
|
579
|
+
br
|
580
|
+
e 'Grönlandwale werden vermutlich über 200 Jahre alt. Dies
|
581
|
+
macht sie zu den langlebigsten Säugetieren auf der Welt.'
|
582
|
+
br
|
583
|
+
e 'Eine Theorie wieso Lebewesen altern lautet, dass bei dem
|
584
|
+
Mechanismus des Elektronentransports in den Mitochondrien
|
585
|
+
sogenannte freie Radikale entstehen, welche alle möglichen
|
586
|
+
Schäden in den Zellen hervorrufen und somit das Altern
|
587
|
+
bewirken oder beschleunigen.'
|
588
|
+
br
|
589
|
+
e 'Die Lebenserwartung der Eskimos ist auch heute (~2000)
|
590
|
+
in Grönland deutlich geringer ist als die des Mitteleuropäers.
|
591
|
+
Bei einem Vergleich zwischen Eskimos und Dänen in Dänemark
|
592
|
+
ist die standardisierte Mortalitätsrate der Eskimos an
|
593
|
+
ischämischen Herzkrankheiten niedriger, die gesamte
|
594
|
+
kardiovaskuläre Mortalität aber gleich und die
|
595
|
+
cerebrovaskuläre Mortalität doppelt so hoch. Die Lebensweise
|
596
|
+
und insbesondere die Ernährung, aber auch genetische Faktoren
|
597
|
+
scheinen die Grönländer vor ischämischen Herzkrankheiten zu
|
598
|
+
schützen, aber zu cerebrovaskulären Todesursachen zu
|
599
|
+
prädisponieren.'
|
600
|
+
br
|
601
|
+
e "Nature's nanomachines repair (biological) cells
|
602
|
+
imperfectly."
|
603
|
+
br
|
604
|
+
e 'To save those we love from dissolution.'
|
605
|
+
br
|
606
|
+
e 'To speak of "immortality" when the prospect is only
|
607
|
+
long life would be to ignore the facts or to misuse
|
608
|
+
words.'
|
609
|
+
br
|
610
|
+
e 'Awake not to a world of strangers but to the smiles
|
611
|
+
of familiar faces.'
|
612
|
+
br
|
613
|
+
}
|
614
|
+
# ========================================================================= #
|
615
|
+
# === What did wise people and older civilisations say about aging?
|
616
|
+
# ========================================================================= #
|
617
|
+
h2 'What did wise people and older civilisations say about aging?',
|
618
|
+
'martb4px'
|
619
|
+
div_default {
|
620
|
+
# ======================================================================= #
|
621
|
+
# === Avicenna from the Islamic tradition
|
622
|
+
# ======================================================================= #
|
623
|
+
h4 'Avicenna from the Islamic tradition',
|
624
|
+
'martb2px'
|
625
|
+
p_default {
|
626
|
+
le string_a(:avicenna,
|
627
|
+
content: 'Avicenna',
|
628
|
+
css_class: 'BOLD')+
|
629
|
+
' (980-1037 after Jesus Christ) had a remarkable insight in that
|
630
|
+
he suggested that the art of maintaing the health is not the art
|
631
|
+
of averting death or of securing the utmost longevity possible.
|
632
|
+
Instead <b class="italic">the art of maintaining health consists
|
633
|
+
in guiding the body to its natural span of life</b>.'
|
634
|
+
}
|
635
|
+
# ======================================================================= #
|
636
|
+
# === St. Thomas Aquinas
|
637
|
+
# ======================================================================= #
|
638
|
+
h4 'St. Thomas Aquinas',
|
639
|
+
'martb2px'
|
640
|
+
p_default {
|
641
|
+
le string_a(:thomas_aquinas,
|
642
|
+
content: 'St. Thomas Aquinas',
|
643
|
+
css_class: 'BOLD')+
|
644
|
+
' (1225-1274 after Jesus Christ) linked death to the inability
|
645
|
+
of men and women to control their minds or maintain their
|
646
|
+
willpower. This was interesting in that the implication has been
|
647
|
+
that the supernatural power taken by God could be restored,
|
648
|
+
achieving perfect health and immortality, if "the mind triumps
|
649
|
+
over the body". This philosophy remains an important element
|
650
|
+
of the ideology that drives the modern <b>anti-aging movement</b>.'
|
651
|
+
}
|
652
|
+
# ======================================================================= #
|
653
|
+
# === The Taoists
|
654
|
+
# ======================================================================= #
|
655
|
+
h4 'The Taoists',
|
656
|
+
'martb2px'
|
657
|
+
p_default {
|
658
|
+
le string_a(:the_taoists,
|
659
|
+
content: 'The Taoists',
|
660
|
+
css_class: 'BOLD')+
|
661
|
+
' had some interesting concepts in regards to aging, death and
|
662
|
+
immortality. They took prolongevitism from the realm of magic
|
663
|
+
and carried it forward towards some sort of <b>proto-science</b>.'
|
664
|
+
br
|
665
|
+
e '<b>Taoists</b> tried to link between the mortal body and the immortal
|
666
|
+
heavens. They would attempt to control the breath as means of
|
667
|
+
physical contact with the heavens. They would reduce their
|
668
|
+
metabolic rate and use of oxygen, while adopting a near-starvation
|
669
|
+
diet consisting mostly of fruits.'
|
670
|
+
br
|
671
|
+
e 'The belief was that transformation from one thing to
|
672
|
+
another (such as turning lead into gold) could also be applied
|
673
|
+
to the sick, in other words to convert sickness into health,
|
674
|
+
or mortality to immortality - these were the basic beliefs
|
675
|
+
of the <b>Taoists</b>.'
|
676
|
+
br
|
677
|
+
e 'Do note that <b>Taoists</b> were not the first to have
|
678
|
+
originated the notion of prolongevity, though.'
|
679
|
+
}
|
680
|
+
# ======================================================================= #
|
681
|
+
# === The old Alchemists
|
682
|
+
# ======================================================================= #
|
683
|
+
h4 'The old Alchemists',
|
684
|
+
'martb2px'
|
685
|
+
p_default {
|
686
|
+
le string_a(:the_old_alchemists,
|
687
|
+
content: 'The old Alchemists',
|
688
|
+
css_class: 'BOLD')+
|
689
|
+
' believed that all the proper steps required to transform mortal
|
690
|
+
men into immortal beings would eventuelly be discovered.'
|
691
|
+
}
|
692
|
+
}
|
693
|
+
}}
|