datacite-mapping 0.2.1 → 0.2.2

data/spec/data/dash1/ucsf-ark+=b7272=q67p8w9z-mrt-datacite.xml

@@ -1,63 +1,64 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
-<identifier identifierType="DOI">10.7272/Q67P8W9Z </identifier>
-<creators>
-<creator>
-<creatorName>Zhang, Yu</creatorName>
-</creator>
-<creator>
-<creatorName>Du, An-Tao</creatorName>
-</creator>
-<creator>
-<creatorName>Hayasaka, Satoru</creatorName>
-</creator>
-<creator>
-<creatorName>Jahng, Geon-ho</creatorName>
-</creator>
-<creator>
-<creatorName>Hlavin, Jennifer</creatorName>
-</creator>
-<creator>
-<creatorName>Zhan, Wang</creatorName>
-</creator>
-<creator>
-<creatorName>Weiner, Michael W.</creatorName>
-</creator>
-<creator>
-<creatorName>Schuff, Norbert</creatorName>
-</creator>
-<creator>
-<creatorName>Memory and Aging Center</creatorName>
-</creator>
-</creators>
-<titles>
-<title>Patterns of age-related water diffusion changes in human brain by concordance and discordance analysis.</title>
-</titles>
-<publisher>University of California, San Francisco</publisher>
-<publicationYear>2012</publicationYear>
-<subjects>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Adult</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Human</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Magnetic Resonance Imaging</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Diffusion Magnetic Resonance Imaging</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Brain</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Aged</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Middle Aged</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Young Adult</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Anisotropy</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Reference Values</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Aging</subject>
-</subjects>
-<contributors>
-<contributor contributorType="ResearchGroup">
-<contributorName>UCSF Center for Imaging of Neurodegenerative Diseases</contributorName>
-</contributor>
-</contributors>
-<resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
-<relatedIdentifiers>
-<relatedIdentifier relatedIdentifierType="PMID" relationType="References">19036473</relatedIdentifier>
-</relatedIdentifiers>
-<descriptions>
-<description descriptionType="Abstract">In diffusion tensor imaging (DTI), interpreting changes in terms of fractional anisotropy (FA) and mean diffusivity or axial (D(||)) and radial (D(?)) diffusivity can be ambiguous. The main objective of this study was to gain insight into the heterogeneity of age-related diffusion changes in human brain white matter by analyzing relationships between the diffusion measures in terms of concordance and discordance instead of evaluating them separately, which is difficult to interpret. Fifty-one cognitively normal subjects (22-79 years old) were studied with DTI at 4 Tesla. Age was associated with widespread concordant changes of decreased FA and increased MD but in some regions significant FA reductions occurred discordant to MD changes. Prominent age-related FA reductions were primarily related to greater radial (D(?)) than axial (D(||)) diffusivity changes, potentially reflecting processes of demyelination. In conclusion, concordant/discordant changes of DTI indices provide additional characterization of white matter alterations that accompany normal aging.</description>
-<description descriptionType="Methods">The dataset available here consists of Fractional Anisotropy (FA), Mean Diffusivity (MD), Axial Diffusivity (I1), and Radial Diffusivity (Dra) images as well as subject-study-specific normalization images (B0, see methods in paper) in Analyze format. There are B0, FA, MD, I1, and Dra images for 51 subjects, and a spreadsheet describing each subject's handedness (right, left or ambidextrous), age (at time of scan), gender, ApoE alleles, and Mini-Mental State Exam score. Data Acquisition Location: San Francisco VA Medical Center; Scanner Type: Siemens Bruker 4T, equipped with a birdcage transmit and 8 channel receive coil. DTI was based on a dual spin-echo echo-planar imaging (EPI) sequence, augmented by parallel imaging acceleration (GRAPPA) by a factor 2 to reduce susceptibility distortions. Other imaging parameters were: TR/TE = 6000/77 ms; field of view 256 cm × 224 cm; 128 × 112 matrix size, yielding 2 mm × 2 mm in-plane resolution; 40 continuous slices, each 3 mm thick. A diffusion reference image (no diffusion gradient b = 0) and six diffusion-weighted images (b = 800 s/mm2 along 6 non-collinear directions) were acquired. Four DTI scans were acquired and averaged after motion correction to boost signal-to-noise.</description>
-</descriptions>
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<identifier identifierType="DOI">10.7272/Q67P8W9Z </identifier>
+<creators>
+<creator>
+<creatorName>Zhang, Yu</creatorName>
+</creator>
+<creator>
+<creatorName>Du, An-Tao</creatorName>
+</creator>
+<creator>
+<creatorName>Hayasaka, Satoru</creatorName>
+</creator>
+<creator>
+<creatorName>Jahng, Geon-ho</creatorName>
+</creator>
+<creator>
+<creatorName>Hlavin, Jennifer</creatorName>
+</creator>
+<creator>
+<creatorName>Zhan, Wang</creatorName>
+</creator>
+<creator>
+<creatorName>Weiner, Michael W.</creatorName>
+</creator>
+<creator>
+<creatorName>Schuff, Norbert</creatorName>
+</creator>
+<creator>
+<creatorName>Memory and Aging Center</creatorName>
+</creator>
+</creators>
+<titles>
+<title>Patterns of age-related water diffusion changes in human brain by concordance and discordance analysis.</title>
+</titles>
+<publisher>University of California, San Francisco</publisher>
+<publicationYear>2012</publicationYear>
+<subjects>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Adult</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Human</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Magnetic Resonance Imaging</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Diffusion Magnetic Resonance Imaging</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Brain</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Aged</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Middle Aged</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Young Adult</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Anisotropy</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Reference Values</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Aging</subject>
+</subjects>
+<contributors>
+<contributor contributorType="ResearchGroup">
+<contributorName>UCSF Center for Imaging of Neurodegenerative Diseases</contributorName>
+</contributor>
+</contributors>
+<resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
+<relatedIdentifiers>
+<relatedIdentifier relatedIdentifierType="PMID" relationType="References">19036473</relatedIdentifier>
+</relatedIdentifiers>
+<descriptions>
+<description descriptionType="Abstract">In diffusion tensor imaging (DTI), interpreting changes in terms of fractional anisotropy (FA) and mean diffusivity or axial (D(||)) and radial (D(?)) diffusivity can be ambiguous. The main objective of this study was to gain insight into the heterogeneity of age-related diffusion changes in human brain white matter by analyzing relationships between the diffusion measures in terms of concordance and discordance instead of evaluating them separately, which is difficult to interpret. Fifty-one cognitively normal subjects (22-79 years old) were studied with DTI at 4 Tesla. Age was associated with widespread concordant changes of decreased FA and increased MD but in some regions significant FA reductions occurred discordant to MD changes. Prominent age-related FA reductions were primarily related to greater radial (D(?)) than axial (D(||)) diffusivity changes, potentially reflecting processes of demyelination. In conclusion, concordant/discordant changes of DTI indices provide additional characterization of white matter alterations that accompany normal aging.</description>
+<description descriptionType="Methods">The dataset available here consists of Fractional Anisotropy (FA), Mean Diffusivity (MD), Axial Diffusivity (I1), and Radial Diffusivity (Dra) images as well as subject-study-specific normalization images (B0, see methods in paper) in Analyze format. There are B0, FA, MD, I1, and Dra images for 51 subjects, and a spreadsheet describing each subject's handedness (right, left or ambidextrous), age (at time of scan), gender, ApoE alleles, and Mini-Mental State Exam score. Data Acquisition Location: San Francisco VA Medical Center; Scanner Type: Siemens Bruker 4T, equipped with a birdcage transmit and 8 channel receive coil. DTI was based on a dual spin-echo echo-planar imaging (EPI) sequence, augmented by parallel imaging acceleration (GRAPPA) by a factor 2 to reduce susceptibility distortions. Other imaging parameters were: TR/TE = 6000/77 ms; field of view 256 cm × 224 cm; 128 × 112 matrix size, yielding 2 mm × 2 mm in-plane resolution; 40 continuous slices, each 3 mm thick. A diffusion reference image (no diffusion gradient b = 0) and six diffusion-weighted images (b = 800 s/mm2 along 6 non-collinear directions) were acquired. Four DTI scans were acquired and averaged after motion correction to boost signal-to-noise.</description>
+</descriptions>
 </resource>

data/spec/data/dash1/ucsf-ark+=b7272=q68g8hmp-mrt-datacite.xml

@@ -1,5 +1,6 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
-<identifier identifierType="DOI"/>
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<identifier identifierType="DOI"></identifier>
 <creators>
 <creator><creatorName>Malone, Ruth E.</creatorName></creator>
 <creator><creatorName>McDaniel, Patricia A.</creatorName></creator>
@@ -21,4 +22,4 @@
 <description descriptionType="Abstract">This SPSS dataset contains 1,159 records (from 1995-2013) representing the content of media items published in the US concerning employers who chose to hire only nonsmokers. The Excel spreadsheet contains a list of the titles, authors, publication sources, and publication dates of all the media items in the SPSS database.</description>
 <description descriptionType="Methods">There are 71 variables in the SPSS dataset that cover the characteristics of each media item, as well as the content.</description>
 </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucsf-ark+=b7272=q6bg2kwf-mrt-datacite.xml

@@ -1,63 +1,65 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
-<identifier identifierType="DOI">10.7272/Q6BG2KWF </identifier>
-<creators>
-<creator>
-<creatorName>Harper, Cynthia</creatorName>
-</creator>
-<creator>
-<creatorName>Blanchard, Kelly</creatorName>
-</creator>
-<creator>
-<creatorName>Chipato, Tsungai</creatorName>
-</creator>
-<creator>
-<creatorName>Nhemachena, Taazadza</creatorName>
-</creator>
-<creator>
-<creatorName>Ramjee, Gita</creatorName>
-</creator>
-<creator>
-<creatorName>Blum, Maya</creatorName>
-</creator>
-</creators>
-<titles>
-<title>Provider counseling and provision of female condom in South Africa and Zimbabwe</title>
-</titles>
-<publisher>University of California, San Francisco</publisher>
-<publicationYear>2012</publicationYear>
-<subjects>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">HIV</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Prevention</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Female condoms</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Health care providers</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Southern Africa</subject>
-</subjects>
-<contributors>
-<contributor contributorType="ResearchGroup">
-<contributor>UCSF Bixby Center for Global Reproductive Health</contributor> 
-</contributor>
-<contributor contributorType="ResearchGroup">
-<contributor>Ibis Reproductive Health</contributor> 
-</contributor>
-<contributor contributorType="ResearchGroup">
-<contributor>UZ-UCSF Collaborative Programme on Women's Health</contributor> 
-</contributor>
-<contributor contributorType="ResearchGroup">
-<contributor>South African Medical Research Council HIV Prevention Research Unit</contributor> 
-</contributor>
-</contributors>
-<dates>
-<date dateType="Collected">2008-2009</date>
-</dates>
-<resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
-<relatedIdentifiers>
-<relatedIdentifier relatedIdentifierType="PMID" relationType="References">23512836</relatedIdentifier>
-</relatedIdentifiers>
-<rightsList>
-<rights>Terms of Use for these data are outlined in the associated Data Use Agreement</rights>
-</rightsList>
-<descriptions>
-<description descriptionType="Abstract">Objectives: Female condoms are the only female-initiated HIV and pregnancy prevention technology currently available. We examined female condom counseling and provision among providers in South Africa and Zimbabwe, high HIV-prevalence countries. Design: Cross-sectional study using a nationally-representative survey. Setting: All facilities that provide family planning or HIV/STI services in the two countries. Participants: National probability sample of 1,444 nurses and physicians who provide family planning or HIV/STI services. Primary and secondary outcome measures: Female condom practices with different female patients, including adolescents, married women, women using hormonal contraception, and by HIV status. Using multivariable logistic analysis, we measured variations in condom counseling by provider characteristics. Results: Most providers reported offering female condoms (88%), but perceived a need for novel female barrier methods for HIV/STI prevention (85%). By patient type, providers reported less frequent female condom counseling of adolescents (55%), women using hormonal contraception (65%), and married women (66%), compared to unmarried (74%) or HIV-positive women (82%). Multivariable results showed providers in South Africa were less likely to counsel women on female condoms than in Zimbabwe (OR=0.48, 95% CI: 0.35-0.68, p= 0.001). However, South African providers were more likely to counsel women on male condoms (OR=2.39, 95% CI: 1.57-3.65, p= 0.001). Nurses counseled patients on female condoms more frequently than physicians (OR=5.41, 95% CI: 3.26-8.98, p= 0.001). HIV training, family planning training, provider location (urban vs. rural), and facility type (hospital vs. clinic) were not associated with greater condom counseling. Conclusions: Female condoms were integrated into provider counseling and care, although providers reported a need for new female-initiated multipurpose prevention technologies, suggesting female condoms do not meet all patient/provider needs or are not adequately well-known or accessible. Providers should be included in HIV training efforts to raise awareness of new and existing products, and encouraged to educate all women.</description>
-<description descriptionType="Methods">Stata dataset</description>
-</descriptions>
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
+ xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<identifier identifierType="DOI">10.7272/Q6BG2KWF </identifier>
+<creators>
+<creator>
+<creatorName>Harper, Cynthia</creatorName>
+</creator>
+<creator>
+<creatorName>Blanchard, Kelly</creatorName>
+</creator>
+<creator>
+<creatorName>Chipato, Tsungai</creatorName>
+</creator>
+<creator>
+<creatorName>Nhemachena, Taazadza</creatorName>
+</creator>
+<creator>
+<creatorName>Ramjee, Gita</creatorName>
+</creator>
+<creator>
+<creatorName>Blum, Maya</creatorName>
+</creator>
+</creators>
+<titles>
+<title>Provider counseling and provision of female condom in South Africa and Zimbabwe</title>
+</titles>
+<publisher>University of California, San Francisco</publisher>
+<publicationYear>2012</publicationYear>
+<subjects>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">HIV</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Prevention</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Female condoms</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Health care providers</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Southern Africa</subject>
+</subjects>
+<contributors>
+<contributor contributorType="ResearchGroup">
+    <contributorName>UCSF Bixby Center for Global Reproductive Health</contributorName>
+</contributor>
+<contributor contributorType="ResearchGroup">
+    <contributorName>Ibis Reproductive Health</contributorName>
+</contributor>
+<contributor contributorType="ResearchGroup">
+    <contributorName>UZ-UCSF Collaborative Programme on Women's Health</contributorName>
+</contributor>
+<contributor contributorType="ResearchGroup">
+    <contributorName>South African Medical Research Council HIV Prevention Research Unit</contributorName> 
+</contributor>
+</contributors>
+<dates>
+<date dateType="Collected">2008-2009</date>
+</dates>
+<resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
+<relatedIdentifiers>
+<relatedIdentifier relatedIdentifierType="PMID" relationType="References">23512836</relatedIdentifier>
+</relatedIdentifiers>
+<rightsList>
+    <rights rightsURI="doi:10.5060/D8PP47">Terms of use are available at: doi:10.5060/D8PP47</rights>
+</rightsList>
+<descriptions>
+<description descriptionType="Abstract">Objectives: Female condoms are the only female-initiated HIV and pregnancy prevention technology currently available. We examined female condom counseling and provision among providers in South Africa and Zimbabwe, high HIV-prevalence countries. Design: Cross-sectional study using a nationally-representative survey. Setting: All facilities that provide family planning or HIV/STI services in the two countries. Participants: National probability sample of 1,444 nurses and physicians who provide family planning or HIV/STI services. Primary and secondary outcome measures: Female condom practices with different female patients, including adolescents, married women, women using hormonal contraception, and by HIV status. Using multivariable logistic analysis, we measured variations in condom counseling by provider characteristics. Results: Most providers reported offering female condoms (88%), but perceived a need for novel female barrier methods for HIV/STI prevention (85%). By patient type, providers reported less frequent female condom counseling of adolescents (55%), women using hormonal contraception (65%), and married women (66%), compared to unmarried (74%) or HIV-positive women (82%). Multivariable results showed providers in South Africa were less likely to counsel women on female condoms than in Zimbabwe (OR=0.48, 95% CI: 0.35-0.68, p= 0.001). However, South African providers were more likely to counsel women on male condoms (OR=2.39, 95% CI: 1.57-3.65, p= 0.001). Nurses counseled patients on female condoms more frequently than physicians (OR=5.41, 95% CI: 3.26-8.98, p= 0.001). HIV training, family planning training, provider location (urban vs. rural), and facility type (hospital vs. clinic) were not associated with greater condom counseling. Conclusions: Female condoms were integrated into provider counseling and care, although providers reported a need for new female-initiated multipurpose prevention technologies, suggesting female condoms do not meet all patient/provider needs or are not adequately well-known or accessible. Providers should be included in HIV training efforts to raise awareness of new and existing products, and encouraged to educate all women.</description>
+<description descriptionType="Methods">Stata dataset</description>
+</descriptions>
 </resource>

data/spec/data/dash1/ucsf-ark+=b7272=q6c8276k-mrt-datacite.xml

@@ -1,4 +1,5 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
   <identifier identifierType="DOI"/>
   <creators>
     <creator>
@@ -40,4 +41,4 @@ FIG 3.  Contraction in isolated heart muscle
 FIG 4.  Telemetry blood pressure and heart rate in vivo</description>
     <description descriptionType="Other">NIH RO1 HL31113, VA BX001970</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucsf-ark+=b7272=q6cc0xmh-mrt-datacite.xml

@@ -1,63 +1,64 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
-<identifier identifierType="DOI">10.7272/Q6CC0XMH</identifier>
-<creators>
-<creator>
-<creatorName>Zhang, Yu</creatorName>
-</creator>
-<creator>
-<creatorName>Schuff, Norbert</creatorName>
-</creator>
-<creator>
-<creatorName>Du, An-Tao</creatorName>
-</creator>
-<creator>
-<creatorName>Rosen, Howard J.</creatorName>
-</creator>
-<creator>
-<creatorName>Kramer, Joel H.</creatorName>
-</creator>
-<creator>
-<creatorName>Gorno-Tempini, Maria Luisa</creatorName>
-</creator>
-<creator>
-<creatorName>Miller, Bruce L.</creatorName>
-</creator>
-<creator>
-<creatorName>Weiner, Michael W.</creatorName>
-</creator>
-<creator>
-<creatorName>Memory and Aging Center</creatorName>
-</creator>
-</creators>
-<titles>
-<title>White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI</title>
-</titles>
-<publisher>University of California, San Francisco</publisher>
-<publicationYear>2012</publicationYear>
-<subjects>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Adult</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Human</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Magnetic Resonance Imaging</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Diffusion Magnetic Resonance Imaging</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Brain</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Aged</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Middle Aged</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Alzheimer's Disease</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Cross-sectional Studies</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Dementia</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Differential Diagnosis</subject>
-</subjects>
-<contributors>
-<contributor contributorType="ResearchGroup">
-<contributorName>UCSF Center for Imaging of Neurodegenerative Diseases</contributorName>
-</contributor>
-</contributors>
-<resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
-<relatedIdentifiers>
-<relatedIdentifier relatedIdentifierType="PMID" relationType="References">19439421</relatedIdentifier>
-</relatedIdentifiers>
-<descriptions>
-<description descriptionType="Abstract">Frontotemporal dementia (FTD) and Alzheimer's disease are sometimes difficult to differentiate clinically because of overlapping symptoms. Using diffusion tensor imaging (DTI) measurements of fractional anisotropy (FA) can be useful in distinguishing the different patterns of white matter degradation between the two dementias. In this study, we performed MRI scans in a 4 Tesla MRI machine including T1-weighted structural images and diffusion tensor images in 18 patients with FTD, 18 patients with Alzheimer's disease and 19 cognitively normal (CN) controls. FA was measured selectively in specific fibre tracts (including corpus callosum, cingulum, uncinate and corticospinal tracts) as well as globally in a voxel-by-voxel analysis. Patients with FTD were associated with reductions of FA in frontal and temporal regions including the anterior corpus callosum (P &lt; 0.001), bilateral anterior (left P &lt; 0.001; right P = 0.005), descending (left P &lt; 0.001; right P = 0.003) cingulum tracts, and uncinate tracts (left P &lt; 0.001; right P = 0.005), compared to controls. Patients with Alzheimer's disease were associated with reductions of FA in parietal, temporal and frontal regions including the left anterior (P = 0.003) and posterior (P = 0.002) cingulum tracts, bilateral descending cingulum tracts (P &lt; 0.001) and left uncinate tracts (P &lt; 0.001) compared to controls. When compared with Alzheimer's disease, FTD was associated with greater reductions of FA in frontal brain regions, whereas no region in Alzheimer's disease showed greater reductions of FA when compared to FTD. In conclusion, the regional patterns of anisotropy reduction in FTD and Alzheimer's disease compared to controls suggest a characteristic distribution of white matter degradation in each disease. Moreover, the white matter degradation seems to be more prominent in FTD than in Alzheimer's disease. Taken together, the results suggest that white matter degradation measured with DTI may improve the diagnostic differentiation between FTD and Alzheimer's disease.</description>
-<description descriptionType="Methods">The dataset available here consists of Fractional Anisotropy (FA) and Mean Diffusivity (MD) images in Analyze format. There are FA &amp; MD images for 55 subjects (some subjects have two timepoints, as indicated by a -1 or -2 following subject ID in the filename, please disregard timepoint 2 at this time), and a spreadsheet describing each subject’s age (at time of scan), gender, diagnosis (Normal Control, Alzheimer’s Dissease, or Frontotemporal Dementia), ApoE alleles, and Mini-Mental State Exam score. Data Acquisition Location: San Francisco VA Medical Center; Scanner Type: Siemens Bruker 4T, equipped with a birdcage transmit and eight channel receive coil. DTI was based on a dual spin-echo echo-planar imaging (EPI) sequence supplemented with parallel imaging acceleration (GRAPPA) with a factor 2 to reduce susceptibility distortions. Other imaging parameters were: TR/TE = 6000/77 ms; field of view 256 × 224 cm; 128 × 112 matrix size, yielding 2 × 2 mm2 in-plane resolution; 40 continuous 3 mm slices. A reference image (no diffusion gradient b = 0) and six diffusion-weighted images (b = 800 s/mm2 along six non-collinear directions) were acquired. Four DTI scans were acquired and averaged after motion correction to boost signal-to-noise.</description>
-</descriptions>
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+<identifier identifierType="DOI">10.7272/Q6CC0XMH</identifier>
+<creators>
+<creator>
+<creatorName>Zhang, Yu</creatorName>
+</creator>
+<creator>
+<creatorName>Schuff, Norbert</creatorName>
+</creator>
+<creator>
+<creatorName>Du, An-Tao</creatorName>
+</creator>
+<creator>
+<creatorName>Rosen, Howard J.</creatorName>
+</creator>
+<creator>
+<creatorName>Kramer, Joel H.</creatorName>
+</creator>
+<creator>
+<creatorName>Gorno-Tempini, Maria Luisa</creatorName>
+</creator>
+<creator>
+<creatorName>Miller, Bruce L.</creatorName>
+</creator>
+<creator>
+<creatorName>Weiner, Michael W.</creatorName>
+</creator>
+<creator>
+<creatorName>Memory and Aging Center</creatorName>
+</creator>
+</creators>
+<titles>
+<title>White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI</title>
+</titles>
+<publisher>University of California, San Francisco</publisher>
+<publicationYear>2012</publicationYear>
+<subjects>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Adult</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Human</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Magnetic Resonance Imaging</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Diffusion Magnetic Resonance Imaging</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Brain</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Aged</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Middle Aged</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Alzheimer's Disease</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Cross-sectional Studies</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Dementia</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Differential Diagnosis</subject>
+</subjects>
+<contributors>
+<contributor contributorType="ResearchGroup">
+<contributorName>UCSF Center for Imaging of Neurodegenerative Diseases</contributorName>
+</contributor>
+</contributors>
+<resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
+<relatedIdentifiers>
+<relatedIdentifier relatedIdentifierType="PMID" relationType="References">19439421</relatedIdentifier>
+</relatedIdentifiers>
+<descriptions>
+<description descriptionType="Abstract">Frontotemporal dementia (FTD) and Alzheimer's disease are sometimes difficult to differentiate clinically because of overlapping symptoms. Using diffusion tensor imaging (DTI) measurements of fractional anisotropy (FA) can be useful in distinguishing the different patterns of white matter degradation between the two dementias. In this study, we performed MRI scans in a 4 Tesla MRI machine including T1-weighted structural images and diffusion tensor images in 18 patients with FTD, 18 patients with Alzheimer's disease and 19 cognitively normal (CN) controls. FA was measured selectively in specific fibre tracts (including corpus callosum, cingulum, uncinate and corticospinal tracts) as well as globally in a voxel-by-voxel analysis. Patients with FTD were associated with reductions of FA in frontal and temporal regions including the anterior corpus callosum (P &lt; 0.001), bilateral anterior (left P &lt; 0.001; right P = 0.005), descending (left P &lt; 0.001; right P = 0.003) cingulum tracts, and uncinate tracts (left P &lt; 0.001; right P = 0.005), compared to controls. Patients with Alzheimer's disease were associated with reductions of FA in parietal, temporal and frontal regions including the left anterior (P = 0.003) and posterior (P = 0.002) cingulum tracts, bilateral descending cingulum tracts (P &lt; 0.001) and left uncinate tracts (P &lt; 0.001) compared to controls. When compared with Alzheimer's disease, FTD was associated with greater reductions of FA in frontal brain regions, whereas no region in Alzheimer's disease showed greater reductions of FA when compared to FTD. In conclusion, the regional patterns of anisotropy reduction in FTD and Alzheimer's disease compared to controls suggest a characteristic distribution of white matter degradation in each disease. Moreover, the white matter degradation seems to be more prominent in FTD than in Alzheimer's disease. Taken together, the results suggest that white matter degradation measured with DTI may improve the diagnostic differentiation between FTD and Alzheimer's disease.</description>
+<description descriptionType="Methods">The dataset available here consists of Fractional Anisotropy (FA) and Mean Diffusivity (MD) images in Analyze format. There are FA &amp; MD images for 55 subjects (some subjects have two timepoints, as indicated by a -1 or -2 following subject ID in the filename, please disregard timepoint 2 at this time), and a spreadsheet describing each subject’s age (at time of scan), gender, diagnosis (Normal Control, Alzheimer’s Dissease, or Frontotemporal Dementia), ApoE alleles, and Mini-Mental State Exam score. Data Acquisition Location: San Francisco VA Medical Center; Scanner Type: Siemens Bruker 4T, equipped with a birdcage transmit and eight channel receive coil. DTI was based on a dual spin-echo echo-planar imaging (EPI) sequence supplemented with parallel imaging acceleration (GRAPPA) with a factor 2 to reduce susceptibility distortions. Other imaging parameters were: TR/TE = 6000/77 ms; field of view 256 × 224 cm; 128 × 112 matrix size, yielding 2 × 2 mm2 in-plane resolution; 40 continuous 3 mm slices. A reference image (no diffusion gradient b = 0) and six diffusion-weighted images (b = 800 s/mm2 along six non-collinear directions) were acquired. Four DTI scans were acquired and averaged after motion correction to boost signal-to-noise.</description>
+</descriptions>
 </resource>

data/spec/data/dash1/ucsf-ark+=b7272=q6d798bd-mrt-datacite.xml

@@ -1,5 +1,6 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
-<identifier identifierType="DOI"/>
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<identifier identifierType="DOI"></identifier>
 <creators>
 <creator><creatorName>Chang, Yishin</creatorName></creator>
 <creator><creatorName>Mukherjee, Pratik</creatorName></creator>
@@ -23,4 +24,4 @@
 <description descriptionType="Abstract">Diffusion tensor imaging (DTI) studies of human brain development have consistently shown widespread, but nonlinearly increasing white matter anisotropy through childhood, adolescence, and into adulthood. However, despite its sensitivity to changes in tissue microstructure, DTI lacks the specificity to disentangle distinct microstructural features of white and gray matter.  Neurite orientation dispersion and density imaging (NODDI) is a recently proposed multi-compartment biophysical model of brain microstructure that can estimate non-collinear properties of white matter, such as neurite orientation dispersion (OD) and neurite density (ND). In this study, we apply NODDI to 67 healthy controls aged 7-63 years to investigate changes of OD and ND with brain maturation, with comparison to standard DTI metrics. Using both region-of-interest and voxel-wise analyses, we find that ND exhibits striking increases over the studied age range following a logarithmic growth pattern, while OD rises following an exponential growth pattern. This novel finding is consistent with well-established age-related changes of FA over the lifespan that show growth during childhood and adolescence, plateau during early adulthood, and accelerating decay after the fourth decade of life. Our results suggest that the rise of FA during the first two decades of life is dominated by increasing ND, while the fall in FA after the fourth decade is driven by the exponential rise of OD that overcomes the slower increases of ND. Using partial least squares regression, we further demonstrate that NODDI better predicts chronological age than DTI.  Finally, we show excellent test-retest reliability of NODDI metrics, with coefficients of variation below 5% in all measured regions of interest.  Our results support the conclusion that NODDI reveals biologically specific characteristics of brain development that are more closely linked to the microstructural features of white matter than are the empirical metrics provided by DTI.</description>
 <description descriptionType="Methods">NODDI</description>
 </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucsf-ark+=b7272=q6h12zxh-mrt-datacite.xml

@@ -1,4 +1,5 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
   <identifier identifierType="DOI"/>
   <creators>
     <creator>
@@ -43,4 +44,4 @@ The quantitative dataset, consisting of survey respondents rating of minimum, de
 The qualitative dataset, consisting of the comments portion of the survey, was coded by a group of library staff in order to highlight the different topics discussed. Because a comment often touched on many different topics each comment could receive multiple codes. Once the comments had all been coded the spreadsheet was transformed into a format more suitable for filtering and analysis.
 </description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucsf-ark+=b7272=q6h41pb7-mrt-datacite.xml

@@ -1,60 +1 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
-<identifier identifierType="DOI">10.7272/Q6H41PB7</identifier>
-<creators>
-<creator>
-<creatorName>Zhang, Yu</creatorName>
-</creator>
-<creator>
-<creatorName>Schuff, Norbert</creatorName>
-</creator>
-<creator>
-<creatorName>Woolley, Susan</creatorName>
-</creator>
-<creator>
-<creatorName>Chiang, Gloria</creatorName>
-</creator>
-<creator>
-<creatorName>Boreta, Lauren</creatorName>
-</creator>
-<creator>
-<creatorName>Laxamana, Joel</creatorName>
-</creator>
-<creator>
-<creatorName>Katz, Jonathon</creatorName>
-</creator>
-<creator>
-<creatorName>Weiner, Michael W.</creatorName>
-</creator>
-</creators>
-<titles>
-<title>Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study</title>
-</titles>
-<publisher>University of California, San Francisco</publisher>
-<publicationYear>2012</publicationYear>
-<subjects>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Adult</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Human</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Magnetic Resonance Imaging</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Diffusion Magnetic Resonance Imaging</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Brain</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Amyotropic Lateral Sclerosis</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Disease Progression</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Longitudinal</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Nerve Degeneration</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Nerve Fibers</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Pyramidal tract</subject>
-</subjects>
-<contributors>
-<contributor contributorType="ResearchGroup">
-<contributorName>UCSF Center for Imaging of Neurodegenerative Diseases</contributorName>
-</contributor>
-</contributors>
-<resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
-<relatedIdentifiers>
-<relatedIdentifier relatedIdentifierType="PMID" relationType="References">21760989</relatedIdentifier>
-</relatedIdentifiers>
-<descriptions>
-<description descriptionType="Abstract">Whether longitudinal diffusion tensor MRI imaging (DTI) can capture disease progression in patients with amyotrophic lateral sclerosis (ALS) is unclear. The primary goal of this study was to determine if DTI detects progression of the corticospinal tracts (CST) degeneration in ALS. Seventeen ALS patients and 19 age- and gender-matched healthy controls were scanned with DTI at baseline for cross-sectional analyses. For longitudinal analyses, the ALS patients had repeat DTI scans after eight months. Tractography of the CST was used to guide regions-of-interest (ROI) analysis and complemented by a voxelwise analysis. Cross-sectional study found that baseline FA of the right superior CST was markedly reduced in ALS patients compared to controls. The FA reductions in this region correlated with the disease severity in ALS patients. Longitudinal study found that FA change rate of the right superior CST significantly declined over time. In conclusion, longitudinal DTI study captures progression of upper motor fiber degeneration in ALS. DTI can be useful for monitoring ALS progression and efficacy of treatment interventions.</description>
-<description descriptionType="Methods">The dataset available here consists of Fractional Anisotropy (FA), and Mean Diffusivity (MD) images as well as subject-study-specific normalization images (B0, see methods in paper) in Analyze format. There are B0, FA, and MD images for 53 subjects, and a spreadsheet describing each subject's age (at time of scan), gender, and diagnosis (ALS or Control). For ALS subjects, there are two timepoints (duration between timepoints is indicated) as well as additional info including ALS subtype, side at onset, and scores on the Amyotrophic Lateral Sclerosis Functional Rating Scale–revised (ALSFRSr).</description>
-</descriptions>
-</resource>
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