datacite-mapping 0.2.1 → 0.2.2

data/spec/data/dash1/ucop-ark+=b5060=d8301x-mrt-datacite.xml

@@ -1,4 +1,7 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
+ xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd"
+ xmlns="http://datacite.org/schema/kernel-3">
   <identifier identifierType="DOI">10.5060/d8301x</identifier>
   <creators>
     <creator>
@@ -36,4 +39,4 @@
     <description descriptionType="Abstract">These datasets include information about APC prices or payments gathered from various sources and synthesized into two data sets.  One dataset maps APC prices to publications by partner institution authors in gold OA journals; the other dataset combines tracked APC payment databases from European countries implementing widespread support for the gold OA model.</description>
     <description descriptionType="Other">41400690</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucop-ark+=b5060=d86p4w-mrt-datacite.xml

@@ -1,4 +1,7 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
+ xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd"
+ xmlns="http://datacite.org/schema/kernel-3">
   <identifier identifierType="DOI">10.5060/d86p4w</identifier>
   <creators>
     <creator>
@@ -35,4 +38,4 @@
     <description descriptionType="Abstract">These datasets include aggregated and summarized data describing the publication output of Pay It Forward project partner institutions, as well as provide some data on the characteristics of journals and sources that project partner authors publish in.  Data are aggregated and summarized from Web of Science and Scopus.</description>
     <description descriptionType="Other">41400690</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucop-ark+=b5060=d8bc75-mrt-datacite.xml

@@ -1,4 +1,7 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
+ xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd"
+ xmlns="http://datacite.org/schema/kernel-3">
   <identifier identifierType="DOI">10.5060/d8bc75</identifier>
   <creators>
     <creator>
@@ -37,4 +40,4 @@
     <description descriptionType="Abstract">These datasets are subsets of tables from the NCSES's Higher Education Research and Development Survey.  Tables are limited to include only U.S. Pay It Forward project partner institutions (Harvard, Ohio State, and the University of California system). </description>
     <description descriptionType="Other">41400690</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucop-ark+=b5060=d8g593-mrt-datacite.xml

@@ -1,4 +1,7 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
+ xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd"
+ xmlns="http://datacite.org/schema/kernel-3">
   <identifier identifierType="DOI">10.5060/d8g593</identifier>
   <creators>
     <creator>
@@ -36,4 +39,4 @@
     <description descriptionType="Abstract">This dataset contains the raw data behind three strategies that the Pay It Forward project team considered for estimating the cost of publishing an article in a scholarly journal.</description>
     <description descriptionType="Other">41400690</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucop-ark+=b5060=d8h59d-mrt-datacite.xml

@@ -1,4 +1,5 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
   <identifier identifierType="DOI"/>
   <creators>
     <creator>
@@ -50,4 +51,4 @@ We solicited responses using social media (Twitter feed, blogs at the CDL and PL
 </description>
     <description descriptionType="Other">1448821</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucop-ark+=b5060=d8kw2m-mrt-datacite.xml

@@ -1,4 +1,7 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
+ xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd"
+ xmlns="http://datacite.org/schema/kernel-3">
   <identifier identifierType="DOI">10.5060/d8kw2m</identifier>
   <creators>
     <creator>
@@ -36,4 +39,4 @@
     <description descriptionType="Abstract">These data connect Source Normalized Impact per Paper (SNIP) to list-price APC for a subset of full OA journals in which authors from partner institutions on the PIF project regularly publish.  These data were used for a regression analysis quantifying the relationship between APC pricing and perceived quality of a journal.</description>
     <description descriptionType="Other">41400690</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucop-ark+=b5060=d8rp4v-mrt-datacite.xml

@@ -1,4 +1,5 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
   <identifier identifierType="DOI"/>
   <creators>
     <creator>
@@ -49,4 +50,4 @@ Solicitations were distributed via social media (Twitter, Facebook, Google+), em
 Although the topic of the survey is benign and identification would be unlikely to negatively impact respondents, light anonymization was performed prior to release of the response data. UC affiliation and answers to UC-specific questions were redacted. Respondent locations were grouped into United States and ``other;'' this distinction was preserved only because some questions asked about US government policies. Sub-disciplines with fewer than three respondents were re-coded with the corresponding discipline.
 Listed data journal names were standardized manually, and free text answers to other questions were replaced with ``other.''</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucop-ark+=b5060=d8z59f-mrt-datacite.xml

@@ -1,4 +1,7 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
+ xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd"
+ xmlns="http://datacite.org/schema/kernel-3">
   <identifier identifierType="DOI">10.5060/d8z59f</identifier>
   <creators>
     <creator>
@@ -39,4 +42,4 @@
     <description descriptionType="Methods">Survey conducted using Qualtrics software.  Respondents included faculty, graduate students, and post-doctoral researchers from the University of British Columbia, The Ohio State University, the University of California, Irvine, and the University of California, Davis.  The survey was open from May 20, 2015 to June 10, 2015.  IRB approval for this study was obtained by the University of Tennessee, Knoxville, Office of Research Compliance.</description>
     <description descriptionType="Other">41400690</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucsc-ark+=b7291=d11592-mrt-datacite.xml

@@ -1,4 +1,5 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
   <identifier identifierType="DOI"/>
   <creators>
     <creator>
@@ -31,8 +32,8 @@
     <rights rightsURI="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International (CC-BY 4.0)</rights>
   </rightsList>
   <descriptions>
-    <description descriptionType="Abstract">The Cordillera Huayhuash is the second highest mountain range in the Peruvian Andes and is important for tourism, mining, and local livelihoods. These three economic activities all share an interest in the water quality of the over 50 lakes and associated drainages that exist in the region. Water quality monitoring can help ease tensions between interests from these distinct economic sectors. This dataset reports on two rounds of water quality sampling and testing performed at 56 identified monitoring stations in 2010 and 2011. Several additional spot samples were taken in both years. At each monitoring station field measures such as temperature, pH, and conductivity were taken and samples were collected for laboratory analysis of elemental concentrations (metals and others) and field analysis of biological contamination (enterococcus). The results show contamination from mining activities, from tourism activities and from natural sources. The data is in a comma separated value (CSV) format with two flat files: &quot;Pruebas.csv&quot; contains the measurements of all parameters for each sample; &quot;Estaciones.csv&quot; contains a list of monitoring stations with geographic coordinates; &quot;README.csv&quot; contains the data dictionaries and other metadata (description) for both of the flat files.</description>
+    <description descriptionType="Abstract">The Cordillera Huayhuash is the second highest mountain range in the Peruvian Andes and is important for tourism, mining, and local livelihoods. These three economic activities all share an interest in the water quality of the over 50 lakes and associated drainages that exist in the region. Water quality monitoring can help ease tensions between interests from these distinct economic sectors. This dataset reports on two rounds of water quality sampling and testing performed at 56 identified monitoring stations in 2010 and 2011. Several additional spot samples were taken in both years. At each monitoring station field measures such as temperature, pH, and conductivity were taken and samples were collected for laboratory analysis of elemental concentrations (metals and others) and field analysis of biological contamination (enterococcus). The results show contamination from mining activities, from tourism activities and from natural sources. The data is in a comma separated value (CSV) format with two flat files: "Pruebas.csv" contains the measurements of all parameters for each sample; "Estaciones.csv" contains a list of monitoring stations with geographic coordinates; "README.csv" contains the data dictionaries and other metadata (description) for both of the flat files.</description>
     <description descriptionType="Methods">Two rounds of water quality sampling and testing were performed in 2010 and 2011 at 56 identified monitoring stations in the Cordillera Huayhuash, Peru. Several additional spot samples were taken in both 2010 and 2011. The selection of monitoring stations was guided by several criteria. At least two monitoring stations were identified per watershed; one at the headwaters (slightly downstream from a trekking camp if possible) and one near the confluence with the neighboring watershed. One monitoring station was identified at the source of drinking water for each community. Additional monitoring stations were identified as potential sites of contamination from mining activities. All of the monitoring station identification met Peruvian Ministry of Energy and Mines published protocols (MEM, 1994. Protocolo de Monitoreo de Calidad de Aguas. Lima, Peru: Ministerio de Energia y Minas).  Samples were collected during April and May across two consecutive years; 51 stations in 2010 and 36 stations in 2011 of which 32 stations were used both years (see stations.csv). Field measurements were made for temperature, pH, conductivity, salinity, total dissolved solids, and dissolved oxygen with two distinct field instruments (the Oakton Instruments PCSTester35 multi-parameter tester and the Oakton Instruments ExStik® DO600 oxygen meter respectively). The American Public Health Association (APHA) methods 9222 and 9230 (APHA, 2005. Standard methods for the examination of water and waste water, 21st edition. American Public Health Association, American Water Works Association &amp; Water Environment Federation: Baltimore, Port City Press) were followed for the analysis of fecal coliforms (Enterococcus spp.) in the field. Each measured sample was filtered with a 0.45 micron gridded filter. Each filter was then incubated at approximately 44.5° C for twenty four hours on Agar specially formulated for Enterococcus growth. The number of colonies that appeared was counted and a most probable number (MPN) was calculated using the number of colonies observed and the amount of water originally filtered. In 2010 split filtered (0.45 micron) and unfiltered samples were collected for heavy metal analysis at each monitoring station and in 2011 only unfiltered samples were collected. Across both years ½ liter was used as the sample volume. The collection bottles were provided by the laboratory and were guaranteed to be clean (according to EPA protocols detailed below). The collection of samples in the field followed the EPA protocols published in each method detailed below. In 2010 the unfiltered sample was analyzed for dissolved mercury (Hg) concentrations in a laboratory in Lima (EnviroLab S.A.C) using EPA method 1631 (Cold Vapor Atomic Fluorescence Spectrometry) (EPA, 2002. Method 1631, Revision E: Mercury in Water by Oxidation, Purge and Trap, and Cold Vapor Atomic Fluorescence Spectrometry. Baltimore: United States Environmental Protection Agency). The Mercury measurement was not repeated the second year as no sample from 2010 yielded a positive result and no new sources of mercury were identified. In 2010 the unfiltered sample was analyzed for a full run of elemental concentrations (As, Ba, Be, Cd, Co, Cr, Cu, Mn, Mo, Ni, Pb, Sb, Se, Tl, V, Zn, Ag, B, Bi, Ca, Fe, K, Li, Mg, Na, P, Si, Sn, Sr, and Ti) with the EPA 200.8 method (inductively coupled plasma - mass spectrometry) (EPA, 1994. Method 200.8 Determination of trace elements in waters and wastes by inductively coupled plasma - mass spectrometry. Cincinnati: United States Environmental Protection Agency). In 2011 the elemental analysis was narrowed to aluminum (Al), arsenic (As), cadmium (Cd), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn) based on the results from 2010.</description>
     <description descriptionType="Other">C171-09</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucsc-ark+=b7291=d17p46-mrt-datacite.xml

@@ -1,4 +1,5 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
   <identifier identifierType="DOI"/>
   <creators>
     <creator>
@@ -37,7 +38,7 @@
   </rightsList>
   <descriptions>
     <description descriptionType="Abstract">This data set contains time series from inertial sensors carried by blind subjects walking through pre-determined routes In two buildings in the UCSC campus. The sensors include two MetaWear CPRO (obtaining a tai-axial accelerometer and gyroscope) and two iPhone 6 containing try-axial accelerometer, gyroscopes, and magnetometers.</description>
-    <description descriptionType="Methods">The data is timestamped and annotated. In particular, the paths taken by the blind subjects are subdivided into continuous non-overlapping intervals corresponding, for example, to straight segments or left/right turns. In addition, our annotations contain specific &quot;features&quot;, such as when a blind subject bumped onto an obstacles or stopped momentarily. Intervals and features are specified by their start and end time. An XML schema (WeAllWalk.xsd) has been defined to format these annotations, and is contained in the data set. </description>
+    <description descriptionType="Methods">The data is timestamped and annotated. In particular, the paths taken by the blind subjects are subdivided into continuous non-overlapping intervals corresponding, for example, to straight segments or left/right turns. In addition, our annotations contain specific "features", such as when a blind subject bumped onto an obstacles or stopped momentarily. Intervals and features are specified by their start and end time. An XML schema (WeAllWalk.xsd) has been defined to format these annotations, and is contained in the data set. </description>
     <description descriptionType="Other">2015-321</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucsc-ark+=b7291=d1h59d-mrt-datacite.xml

@@ -1,4 +1,5 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
   <identifier identifierType="DOI"/>
   <creators>
     <creator>
@@ -37,7 +38,7 @@
   <descriptions>
     <description descriptionType="Abstract">We fit the data to a structural model estimated via maximum likelihood (ML) techniques. 
 The model in the matlab code joins discrete time replicator dynamics with a stochastic structure, given by the Dirichlet distribution or, alternatively, by the logistic distribution. </description>
-    <description descriptionType="Methods">This software can be used in the MatLab to estimate payoff matrices from time series data on the frequency of strategies over generations (discrete). Full details can be found in the book by Daniel Friedman and Barry Sinervo, &quot;Evolutionary Games in Natural, Social, and Virtual Worlds&quot;, (Publisher: Oxford University Press, 2016). </description>
-    <description descriptionType="Other"/>
+    <description descriptionType="Methods">This software can be used in the MatLab to estimate payoff matrices from time series data on the frequency of strategies over generations (discrete). Full details can be found in the book by Daniel Friedman and Barry Sinervo, "Evolutionary Games in Natural, Social, and Virtual Worlds", (Publisher: Oxford University Press, 2016). </description>
+    <description descriptionType="Other"></description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucsc-ark+=b7291=d1mw2x-mrt-datacite.xml

@@ -1,4 +1,5 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
   <identifier identifierType="DOI"/>
   <creators>
     <creator>
@@ -36,7 +37,7 @@
     <rights rightsURI="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International (CC-BY 4.0)</rights>
   </rightsList>
   <descriptions>
-    <description descriptionType="Abstract">The software examples are all derived in the book by Daniel Friedman and Barry Sinervo, &quot;Evolutionary Games in Natural, Social, and Virtual Worlds&quot;, published by Oxford University Press (2016). These Excel simulations, R workspaces, and mathematica programs are designed to illustrate diverse games that can be developed for one-population games such as Hawk Dove, RPS, Defect-Cooperate-TFT, to two population games such as Baseball (pitchers versus batters) or Buyer-Seller. The Excel games D-C-TFT and Baseball are derived from Joseph E. Harrington's examples from his book &quot;Games, Strategies, and Decision Making&quot; (Publisher MacMillan, 2009). 
+    <description descriptionType="Abstract">The software examples are all derived in the book by Daniel Friedman and Barry Sinervo, "Evolutionary Games in Natural, Social, and Virtual Worlds", published by Oxford University Press (2016). These Excel simulations, R workspaces, and mathematica programs are designed to illustrate diverse games that can be developed for one-population games such as Hawk Dove, RPS, Defect-Cooperate-TFT, to two population games such as Baseball (pitchers versus batters) or Buyer-Seller. The Excel games D-C-TFT and Baseball are derived from Joseph E. Harrington's examples from his book "Games, Strategies, and Decision Making" (Publisher MacMillan, 2009). 
 
 We also develop continuous time versions of several games in the R programming environment, including an r-K strategy game, a two-population buyer-seller game, and several variations on RPS (all discussed in Chapters 1-4 of Friedman and Sinervo, 2016). 
 
@@ -47,8 +48,8 @@ We also include a mathematica version, based on William Sandholm's Mathematica p
 Also included in this software repository are diverse examples of RPS games using Sandholm's mathematica package Dynamo, such as the yeast RPS of Question 6 in Chapter 3, and diverse RPS mating systems found in Chapter 7 of Friedman and Sinervo (2016).
 
 These examples are intended to spur on the development of projects by students who use the book as a text for a class. </description>
-    <description descriptionType="Methods">The spreadsheets and R software implement discrete or continuous time versions of several evolutionary games as described in the Book by Daniel Friedman and Barry Sinervo, &quot;Evolutionary Games in Natural, Social, and Virtual Worlds&quot;, published by Oxford University Press (2016). 
+    <description descriptionType="Methods">The spreadsheets and R software implement discrete or continuous time versions of several evolutionary games as described in the Book by Daniel Friedman and Barry Sinervo, "Evolutionary Games in Natural, Social, and Virtual Worlds", published by Oxford University Press (2016). 
 
 </description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucsc-ark+=b7291=d1wc74-mrt-datacite.xml

@@ -1,4 +1,5 @@
-<?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
   <identifier identifierType="DOI"/>
   <creators>
     <creator>
@@ -52,4 +53,4 @@
 For further details, see: Bennett, Ryan, Grant McGuire, Máire Ní Chiosáin &amp; Jaye Padgett (2014). An ultrasound study of Connemara Irish palatalization and velarization. Ms., UC Santa Cruz, University College Dublin, and Yale University. Available at &lt;http://humweb.ucsc.edu/jayepadgett/wp/wp-content/uploads/2014/02/Conamara_paper.pdf&gt;.</description>
     <description descriptionType="Other">1424398</description>
   </descriptions>
-</resource>
+</resource>

data/spec/data/dash1/ucsf-ark+=b7272=q600001h-mrt-datacite.xml

@@ -0,0 +1,52 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
+  <identifier identifierType="DOI"/>
+  <creators>
+    <creator>
+      <creatorName>Upadhyay, Ushma D.</creatorName>
+    </creator>
+    <creator>
+      <creatorName>Johns, Nicole E.</creatorName>
+    </creator>
+    <creator>
+      <creatorName>Combellick, Sarah L.</creatorName>
+    </creator>
+    <creator>
+      <creatorName>Kohn, Julia E.</creatorName>
+    </creator>
+    <creator>
+      <creatorName>Keder, Lisa M.</creatorName>
+    </creator>
+    <creator>
+      <creatorName>Roberts, Sarah C.M.</creatorName>
+    </creator>
+  </creators>
+  <titles>
+    <title>Comparison of Outcomes before and after Ohio's Law Mandating Use of the FDA-Approved Protocol for Medication Abortion: A Retrospective Cohort Study</title>
+  </titles>
+  <publisher>UC San Francisco</publisher>
+  <publicationYear>2016</publicationYear>
+  <subjects/>
+  <contributors>
+    <contributor contributorType="DataManager">
+      <contributorName>Upadhyay, Ushma</contributorName>
+    </contributor>
+  </contributors>
+  <relatedIdentifiers>
+    <relatedIdentifier relatedIdentifierType="URL" relationType="Cites">http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002110</relatedIdentifier>
+  </relatedIdentifiers>
+  <resourceType resourceTypeGeneral="Dataset">Dataset</resourceType>
+  <sizes>
+    <size>1432064</size>
+  </sizes>
+  <rightsList>
+    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International (CC-BY 4.0)</rights>
+  </rightsList>
+  <descriptions>
+    <description descriptionType="Abstract">Background: In February 2011, an Ohio law took effect mandating use of the United States Food and Drug Administration (FDA)-approved protocol for mifepristone, which is used with misoprostol for medication abortion.  Other state legislatures have passed or enacted similar laws requiring use of the FDA-approved protocol for medication abortion. The objective of this study is to examine the association of this legal change with medication abortion outcomes and utilization.
+
+Methods and Findings: We used a retrospective cohort design, comparing outcomes of medication abortion patients in the prelaw period to those in the postlaw period. Sociodemographic and clinical chart data were abstracted from all medication abortion patients from 1 y prior to the law’s implementation (January 2010–January 2011) to 3 y post implementation (February 2011–October 2014) at four abortion-providing health care facilities in Ohio. Outcome data were analyzed for all women undergoing abortion at ≤49 d gestation during the study period. The main outcomes were as follows: need for additional intervention following medication abortion (such as aspiration, repeat misoprostol, and blood transfusion), frequency of continuing pregnancy, reports of side effects, and the proportion of abortions that were medication abortions (versus other abortion procedures). Among the 2,783 medication abortions ≤49 d gestation, 4.9% (95% CI: 3.7%–6.2%) in the prelaw and 14.3% (95% CI: 12.6%–16.0%) in the postlaw period required one or more additional interventions. Women obtaining a medication abortion in the postlaw period had three times the odds of requiring an additional intervention as women in the prelaw period (adjusted odds ratio [AOR] = 3.11, 95% CI: 2.27–4.27). In a mixed effects multivariable model that uses facility-months as the unit of analysis to account for lack of independence by site, we found that the law change was associated with a 9.4% (95% CI: 4.0%–18.4%) absolute increase in the rate of requiring an additional intervention.  The most common subsequent intervention in both periods was an additional misoprostol dose and was most commonly administered to treat incomplete abortion. The percentage of women requiring two or more follow-up visits increased from 4.2% (95% CI: 3.0%–5.3%) in the prelaw period to 6.2% (95% CI: 5.5%–8.0%) in the postlaw period (p = 0.003). Continuing pregnancy was rare (0.3%). Overall, 12.6% of women reported at least one side effect during their medication abortion: 8.4% (95% CI: 6.8%–10.0%) in the prelaw period and 15.6% (95% CI: 13.8%–17.3%) in the postlaw period (p &lt; 0.001). Medication abortions fell from 22% (95% CI: 20.8%–22.3%) of all abortions the year before the law went into effect (2010) to 5% (95% CI: 4.8%–5.6%) 3 y after (2014) (p &lt; 0.001). The average patient charge increased from US$426 in 2010 to US$551 in 2014, representing a 16% increase after adjusting for inflation in medical prices.  The primary limitation to the study is that it was a pre/post-observational study with no control group that was not exposed to the law.  
+Conclusions: Ohio law required use of a medication abortion protocol that is associated with a greater need for additional intervention, more visits, more side effects, and higher costs for women relative to the evidence-based protocol.  There is no evidence that the change in law led to improved abortion outcomes.  Indeed, our findings suggest the opposite. In March 2016, the FDA-protocol was updated, so Ohio providers may now legally provide current evidence-based protocols. However, this law is still in place and bans physicians from using mifepristone based on any new developments in clinical research as best practices continue to be updated.
+</description>
+  </descriptions>
+</resource>

data/spec/data/dash1/ucsf-ark+=b7272=q6057cv6-mrt-datacite.xml

@@ -1,96 +1,97 @@
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-<identifier identifierType="DOI">10.7272/Q6057CV6</identifier>
-<creators>
-<creator>
-<creatorName>Cardenas, Valerie</creatorName>
-</creator>
-<creator>
-<creatorName>Reed, Bruce</creatorName>
-</creator>
-<creator>
-<creatorName>Chao, Linda</creatorName>
-</creator>
-<creator>
-<creatorName>Chui, Helena</creatorName>
-</creator>
-<creator>
-<creatorName>Sanossian, Nerses</creatorName>
-</creator>
-<creator>
-<creatorName>DeCarli, Charles</creatorName>
-</creator>
-<creator>
-<creatorName>Mack, Wendy</creatorName>
-</creator>
-<creator>
-<creatorName>Kramer, Joel</creatorName>
-</creator>
-<creator>
-<creatorName>Hodis, Howard</creatorName>
-</creator>
-<creator>
-<creatorName>Yan, Mingzhu</creatorName>
-</creator>
-<creator>
-<creatorName>Buonocore, Michael</creatorName>
-</creator>
-<creator>
-<creatorName>Carmichael, Owen</creatorName>
-</creator>
-<creator>
-<creatorName>Jagust, William J.</creatorName>
-</creator>
-<creator>
-<creatorName>Weiner, Michael W.</creatorName>
-</creator>
-</creators>
-<titles>
-<title>Associations between vascular risk factors, carotid atherosclerosis and cortical volume and thickness in older adults</title>
-</titles>
-<publisher>University of California, San Francisco</publisher>
-<publicationYear>2012</publicationYear>
-<subjects>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Adult</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Male</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Female</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Magnetic Resonance Imaging</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Brain</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Human</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Framingham Cardiovascular Risk Profile</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Aged</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Carotid Intima Media</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Gray Matter</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Cortical Thickness</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Cortical Volume</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Atrophy</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Cerebrovascular Disease</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Stroke</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Myocardial Infarction</subject>
-<subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Infarct</subject>
-</subjects>
-<contributors>
-<contributor contributorType="ResearchGroup">
-<contributorName>UCSF Center for Imaging of Neurodegenerative Diseases</contributorName>
-</contributor>
-</contributors>
-<dates>
-<date dateType="Collected">2009-2011</date>
-</dates>
-<resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
-<relatedIdentifiers>
-<relatedIdentifier relatedIdentifierType="PMID" relationType="References">22984010</relatedIdentifier>
-</relatedIdentifiers>
-<descriptions>
-<description descriptionType="Abstract">Data from healthy and cognitively impaired elderly, enriched for cerebrovascular disease.
-Background and Purpose: To investigate whether the Framingham Cardiovascular Risk Profile (FCRP) and carotid artery intima-media thickness (CIMT) are associated with cortical volume and thickness.
-Results: 152 subjects (82 men) were aged 78 (±7) years old, 94 had a CDR of 0, 58 had a clinical dementia rating (CDR) of 0.5 and the mean mini-mental status examination (MMSE) was 28 ±2. FCRP score was inversely associated with total gray matter (GM) volume, parietal and temporal GM volume (adjusted p&lt;0.04). FCRP was inversely associated with parietal and total cerebral GM thickness (adjusted p&lt;0.03). CIMT was inversely associated with thickness of parietal GM only (adjusted p=0.04). Including history of myocardial infarction or stroke and radiologic evidence of brain infarction, or apoE genotype did not alter relationships with FCRP or CIMT.
-Conclusions: Increased cardiovascular risk was associated with reduced GM volume and thickness in regions also affected by Alzheimer's disease (AD), independent of infarcts and apoE genotype. These results suggest a &quot;double hit&quot; toward developing dementia when someone with incipient AD also has high cardiovascular risk.
-Subjects: Consecutive subjects were identified from an ongoing, longitudinal, multi-institutional Aging Brain program project that recruits subjects with normal cognition to mild cognitive impairment, representing a spectrum of low to high vascular risk14. Most participants were acquired through community-based recruitment using a protocol designed to obtain a demographically diverse cohort, or through sources such as stroke clinics and support groups attended by people with high vascular risk factors. All participants gave written informed consent in accordance with the policies of each institutional review board. Inclusion criteria include age 60 or older, with cognitive function in the normal to mild cognitive impairment range (Clinical Dementia Rating [CDR] score of 0 or 0.5) 15. Persons with history of multiple vascular risk factors, coronary or carotid disease, myocardial infarction, or ischemic stroke were targeted for inclusion, although patients with very large strokes that interfered with estimation of cortical volume and thickness were excluded. Exclusion criteria included evidence of alcohol or substance abuse, head trauma with loss of consciousness lasting longer than 15 minutes, factors contraindicating MRI, and severe medical illness, neurologic or psychiatric disorders unrelated to AD or vascular dementia that could significantly affect brain structure (e.g., schizophrenia and other psychotic disorders, bipolar disorder, current major depression, post-traumatic stress disorder, obsessive-compulsive disorder, liver disease, multiple sclerosis, amyotrophic lateral sclerosis). Participant demographics by CDR are shown in Table 1.
-Measures of cardiovascular risk and carotid atherosclerosis: The FCRP uses empirically-derived age- and gender-adjusted weighting of categorical variables to predict the 10-year risk of coronary heart disease and is a weighted sum of: age, gender, active smoking, diabetes, systolic blood pressure (and/or use of hypertensive medications) and total cholesterol and high-density lipoprotein cholesterol levels13. Higher scores indicate greater coronary risk.
-CIMT was used as a measure of subclinical atherosclerosis. CIMT is a measures of the thickness of the inner two layers of the carotid artery; higher CIMT indicates greater atherosclerosis burden. High-resolution B-mode ultrasound images of the right and left common carotid arteries were obtained with a 7.5-MHz linear array transducer attached to an ATL Apogee ultrasound system (Bothell, WA). CIMT was determined as the average of 70 to 100 measurements between the intima-lumen and media-adventitia interfaces along a 1 cm length just proximal to the carotid artery bulb at the same point of the cardiac cycle using comperterized automated edge detection. Right and left CIMT were measured in each individual whenever possible. For individuals with CIMT measurements from both sides, the maximum of these two quantities was used in subsequent statistical analyses.
-Measure of AD risk: Blood was drawn with the subject's consent for apolipoprotein E genotyping. Genotyping was completed for 102 participants. Subjects with 3/4 or 4/4 combined alleles were classified as apoE e4 positive, and those with 3/3 alleles as apoE e4 negative. Because the 2/4 combined allele is associated with a lower risk of AD16, these subjects were not included in the APOE e4 positive group.</description>
-<description descriptionType="Methods">Consecutive subjects participating in a prospective cohort study of aging and mild cognitive impairment enriched for vascular risk factors for atherosclerosis underwent structural MRI scans at 3T and 4T MRI at three sites. Freesurfer (v5.1) was used to obtain regional measures of neocortical volumes (mm3) and thickness (mm). Multiple linear regression was used to determine the association of FCRP and CIMT with cortical volume and thickness.
-MRI: acquisition: Structural T1-weighted MRI scans for participants were collected on 3T and 4T MRI systems. Forty-three participants were scanned at the University of Southern California using a 3T General Electric Signal HDx system with an 8-channel head coil. Acquired images included a T1-weighted volumetric SPGR (TR = 7 ms, TE = 2.9 ms, TI= 650 ms, 1 mm3 isotropic resolution). Fifty-four participants were scanned at the University of California, Davis research center. Nine participants were scanned using a 3T Siemens Magnetom Trio Syngo System with an 8-channel head coil. Forty-five were scanned using a 3T Siemens Magnetom TrioTim system with an 8-channel head coil. Acquired images for all 54 participants included a T1-weighted volumetric MP-RAGE (TR = 2500, TE = 2.98, TI = 1100, 1 mm3 isotropic resolution). Thirty-three participants were scanned at the San Francisco Veterans Administration Medical Center using a 4T Siemens MedSpec Syngo System with an 8-channel head coil. A T1-weighted volumetric MP-RAGE scan (TR = 2300, TE = 2.84, TI = 950, 1 mm3 isotropic resolution) was acquired. Twenty-two participants were scanned at the University of California, San Francisco Neuroscience Imaging Center using a 3T Siemens Magnetom TrioTim system with a 12-channel head coil. Acquired images included a T1-weighted volumetric MP-RAGE (TR = 2500, TE = 2.98, TI = 1100, 1 mm3 isotropic resolution).
-MRI: processing: The publicly available Freesurfer v5.1 (http://surfer.nmr.mgh.harvard.edu/) volumetric segmentation and cortical surface reconstruction methods were used to obtain regional measures of neocortical volumes (mm3) and thickness (mm). The reconstructed cortical surface models for each participant were manually inspected to ensure segmentation accuracy; regions with poor segmentation accuracy due to poor image quality or misregistration were excluded from further statistical analyses. Cortical surfaces were automatically parcellated17 and combined to create average cortical thickness and volume for total GM and for frontal, temporal, parietal, and occipital lobar regions. Region of interest volumes and thicknesses by cognitive status are shown in Table 2.</description>
-</descriptions>
-</resource>
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+<identifier identifierType="DOI">10.7272/Q6057CV6</identifier>
+<creators>
+<creator>
+<creatorName>Cardenas, Valerie</creatorName>
+</creator>
+<creator>
+<creatorName>Reed, Bruce</creatorName>
+</creator>
+<creator>
+<creatorName>Chao, Linda</creatorName>
+</creator>
+<creator>
+<creatorName>Chui, Helena</creatorName>
+</creator>
+<creator>
+<creatorName>Sanossian, Nerses</creatorName>
+</creator>
+<creator>
+<creatorName>DeCarli, Charles</creatorName>
+</creator>
+<creator>
+<creatorName>Mack, Wendy</creatorName>
+</creator>
+<creator>
+<creatorName>Kramer, Joel</creatorName>
+</creator>
+<creator>
+<creatorName>Hodis, Howard</creatorName>
+</creator>
+<creator>
+<creatorName>Yan, Mingzhu</creatorName>
+</creator>
+<creator>
+<creatorName>Buonocore, Michael</creatorName>
+</creator>
+<creator>
+<creatorName>Carmichael, Owen</creatorName>
+</creator>
+<creator>
+<creatorName>Jagust, William J.</creatorName>
+</creator>
+<creator>
+<creatorName>Weiner, Michael W.</creatorName>
+</creator>
+</creators>
+<titles>
+<title>Associations between vascular risk factors, carotid atherosclerosis and cortical volume and thickness in older adults</title>
+</titles>
+<publisher>University of California, San Francisco</publisher>
+<publicationYear>2012</publicationYear>
+<subjects>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Adult</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Male</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Female</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Magnetic Resonance Imaging</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Brain</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Human</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Framingham Cardiovascular Risk Profile</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Aged</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Carotid Intima Media</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Gray Matter</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Cortical Thickness</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Cortical Volume</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Atrophy</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Cerebrovascular Disease</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Stroke</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Myocardial Infarction</subject>
+<subject subjectScheme="MeSH" schemeURI="http://www.nlm.nih.gov/mesh/">Infarct</subject>
+</subjects>
+<contributors>
+<contributor contributorType="ResearchGroup">
+<contributorName>UCSF Center for Imaging of Neurodegenerative Diseases</contributorName>
+</contributor>
+</contributors>
+<dates>
+<date dateType="Collected">2009-2011</date>
+</dates>
+<resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
+<relatedIdentifiers>
+<relatedIdentifier relatedIdentifierType="PMID" relationType="References">22984010</relatedIdentifier>
+</relatedIdentifiers>
+<descriptions>
+<description descriptionType="Abstract">Data from healthy and cognitively impaired elderly, enriched for cerebrovascular disease.
+Background and Purpose: To investigate whether the Framingham Cardiovascular Risk Profile (FCRP) and carotid artery intima-media thickness (CIMT) are associated with cortical volume and thickness.
+Results: 152 subjects (82 men) were aged 78 (±7) years old, 94 had a CDR of 0, 58 had a clinical dementia rating (CDR) of 0.5 and the mean mini-mental status examination (MMSE) was 28 ±2. FCRP score was inversely associated with total gray matter (GM) volume, parietal and temporal GM volume (adjusted p&lt;0.04). FCRP was inversely associated with parietal and total cerebral GM thickness (adjusted p&lt;0.03). CIMT was inversely associated with thickness of parietal GM only (adjusted p=0.04). Including history of myocardial infarction or stroke and radiologic evidence of brain infarction, or apoE genotype did not alter relationships with FCRP or CIMT.
+Conclusions: Increased cardiovascular risk was associated with reduced GM volume and thickness in regions also affected by Alzheimer's disease (AD), independent of infarcts and apoE genotype. These results suggest a "double hit" toward developing dementia when someone with incipient AD also has high cardiovascular risk.
+Subjects: Consecutive subjects were identified from an ongoing, longitudinal, multi-institutional Aging Brain program project that recruits subjects with normal cognition to mild cognitive impairment, representing a spectrum of low to high vascular risk14. Most participants were acquired through community-based recruitment using a protocol designed to obtain a demographically diverse cohort, or through sources such as stroke clinics and support groups attended by people with high vascular risk factors. All participants gave written informed consent in accordance with the policies of each institutional review board. Inclusion criteria include age 60 or older, with cognitive function in the normal to mild cognitive impairment range (Clinical Dementia Rating [CDR] score of 0 or 0.5) 15. Persons with history of multiple vascular risk factors, coronary or carotid disease, myocardial infarction, or ischemic stroke were targeted for inclusion, although patients with very large strokes that interfered with estimation of cortical volume and thickness were excluded. Exclusion criteria included evidence of alcohol or substance abuse, head trauma with loss of consciousness lasting longer than 15 minutes, factors contraindicating MRI, and severe medical illness, neurologic or psychiatric disorders unrelated to AD or vascular dementia that could significantly affect brain structure (e.g., schizophrenia and other psychotic disorders, bipolar disorder, current major depression, post-traumatic stress disorder, obsessive-compulsive disorder, liver disease, multiple sclerosis, amyotrophic lateral sclerosis). Participant demographics by CDR are shown in Table 1.
+Measures of cardiovascular risk and carotid atherosclerosis: The FCRP uses empirically-derived age- and gender-adjusted weighting of categorical variables to predict the 10-year risk of coronary heart disease and is a weighted sum of: age, gender, active smoking, diabetes, systolic blood pressure (and/or use of hypertensive medications) and total cholesterol and high-density lipoprotein cholesterol levels13. Higher scores indicate greater coronary risk.
+CIMT was used as a measure of subclinical atherosclerosis. CIMT is a measures of the thickness of the inner two layers of the carotid artery; higher CIMT indicates greater atherosclerosis burden. High-resolution B-mode ultrasound images of the right and left common carotid arteries were obtained with a 7.5-MHz linear array transducer attached to an ATL Apogee ultrasound system (Bothell, WA). CIMT was determined as the average of 70 to 100 measurements between the intima-lumen and media-adventitia interfaces along a 1 cm length just proximal to the carotid artery bulb at the same point of the cardiac cycle using comperterized automated edge detection. Right and left CIMT were measured in each individual whenever possible. For individuals with CIMT measurements from both sides, the maximum of these two quantities was used in subsequent statistical analyses.
+Measure of AD risk: Blood was drawn with the subject's consent for apolipoprotein E genotyping. Genotyping was completed for 102 participants. Subjects with 3/4 or 4/4 combined alleles were classified as apoE e4 positive, and those with 3/3 alleles as apoE e4 negative. Because the 2/4 combined allele is associated with a lower risk of AD16, these subjects were not included in the APOE e4 positive group.</description>
+<description descriptionType="Methods">Consecutive subjects participating in a prospective cohort study of aging and mild cognitive impairment enriched for vascular risk factors for atherosclerosis underwent structural MRI scans at 3T and 4T MRI at three sites. Freesurfer (v5.1) was used to obtain regional measures of neocortical volumes (mm3) and thickness (mm). Multiple linear regression was used to determine the association of FCRP and CIMT with cortical volume and thickness.
+MRI: acquisition: Structural T1-weighted MRI scans for participants were collected on 3T and 4T MRI systems. Forty-three participants were scanned at the University of Southern California using a 3T General Electric Signal HDx system with an 8-channel head coil. Acquired images included a T1-weighted volumetric SPGR (TR = 7 ms, TE = 2.9 ms, TI= 650 ms, 1 mm3 isotropic resolution). Fifty-four participants were scanned at the University of California, Davis research center. Nine participants were scanned using a 3T Siemens Magnetom Trio Syngo System with an 8-channel head coil. Forty-five were scanned using a 3T Siemens Magnetom TrioTim system with an 8-channel head coil. Acquired images for all 54 participants included a T1-weighted volumetric MP-RAGE (TR = 2500, TE = 2.98, TI = 1100, 1 mm3 isotropic resolution). Thirty-three participants were scanned at the San Francisco Veterans Administration Medical Center using a 4T Siemens MedSpec Syngo System with an 8-channel head coil. A T1-weighted volumetric MP-RAGE scan (TR = 2300, TE = 2.84, TI = 950, 1 mm3 isotropic resolution) was acquired. Twenty-two participants were scanned at the University of California, San Francisco Neuroscience Imaging Center using a 3T Siemens Magnetom TrioTim system with a 12-channel head coil. Acquired images included a T1-weighted volumetric MP-RAGE (TR = 2500, TE = 2.98, TI = 1100, 1 mm3 isotropic resolution).
+MRI: processing: The publicly available Freesurfer v5.1 (http://surfer.nmr.mgh.harvard.edu/) volumetric segmentation and cortical surface reconstruction methods were used to obtain regional measures of neocortical volumes (mm3) and thickness (mm). The reconstructed cortical surface models for each participant were manually inspected to ensure segmentation accuracy; regions with poor segmentation accuracy due to poor image quality or misregistration were excluded from further statistical analyses. Cortical surfaces were automatically parcellated17 and combined to create average cortical thickness and volume for total GM and for frontal, temporal, parietal, and occipital lobar regions. Region of interest volumes and thicknesses by cognitive status are shown in Table 2.</description>
+</descriptions>
+</resource>