wormsim 0.0.1__py3-none-any.whl

wormsim/components/mechanism/x86_64/slo1_egl19.c

@@ -0,0 +1,820 @@
+/* Created by Language version: 7.7.0 */
+/* VECTORIZED */
+#define NRN_VECTORIZED 1
+#include <stdio.h>
+#include <stdlib.h>
+#include <math.h>
+#include "scoplib_ansi.h"
+#undef PI
+#define nil 0
+#include "md1redef.h"
+#include "section.h"
+#include "nrniv_mf.h"
+#include "md2redef.h"
+ 
+#if METHOD3
+extern int _method3;
+#endif
+
+#if !NRNGPU
+#undef exp
+#define exp hoc_Exp
+extern double hoc_Exp(double);
+#endif
+ 
+#define nrn_init _nrn_init__slo1_egl19
+#define _nrn_initial _nrn_initial__slo1_egl19
+#define nrn_cur _nrn_cur__slo1_egl19
+#define _nrn_current _nrn_current__slo1_egl19
+#define nrn_jacob _nrn_jacob__slo1_egl19
+#define nrn_state _nrn_state__slo1_egl19
+#define _net_receive _net_receive__slo1_egl19 
+#define setparames setparames__slo1_egl19 
+#define states states__slo1_egl19 
+ 
+#define _threadargscomma_ _p, _ppvar, _thread, _nt,
+#define _threadargsprotocomma_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt,
+#define _threadargs_ _p, _ppvar, _thread, _nt
+#define _threadargsproto_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt
+ 	/*SUPPRESS 761*/
+	/*SUPPRESS 762*/
+	/*SUPPRESS 763*/
+	/*SUPPRESS 765*/
+	 extern double *getarg();
+ /* Thread safe. No static _p or _ppvar. */
+ 
+#define t _nt->_t
+#define dt _nt->_dt
+#define gbslo1 _p[0]
+#define minf _p[1]
+#define tm _p[2]
+#define mcavinf _p[3]
+#define tmcav _p[4]
+#define hcavinf _p[5]
+#define thcav _p[6]
+#define m _p[7]
+#define hcav _p[8]
+#define mcav _p[9]
+#define ek _p[10]
+#define ik _p[11]
+#define Dm _p[12]
+#define Dhcav _p[13]
+#define Dmcav _p[14]
+#define v _p[15]
+#define _g _p[16]
+#define _ion_ek	*_ppvar[0]._pval
+#define _ion_ik	*_ppvar[1]._pval
+#define _ion_dikdv	*_ppvar[2]._pval
+ 
+#if MAC
+#if !defined(v)
+#define v _mlhv
+#endif
+#if !defined(h)
+#define h _mlhh
+#endif
+#endif
+ 
+#if defined(__cplusplus)
+extern "C" {
+#endif
+ static int hoc_nrnpointerindex =  -1;
+ static Datum* _extcall_thread;
+ static Prop* _extcall_prop;
+ /* external NEURON variables */
+ /* declaration of user functions */
+ static void _hoc_setparames(void);
+ static int _mechtype;
+extern void _nrn_cacheloop_reg(int, int);
+extern void hoc_register_prop_size(int, int, int);
+extern void hoc_register_limits(int, HocParmLimits*);
+extern void hoc_register_units(int, HocParmUnits*);
+extern void nrn_promote(Prop*, int, int);
+extern Memb_func* memb_func;
+ 
+#define NMODL_TEXT 1
+#if NMODL_TEXT
+static const char* nmodl_file_text;
+static const char* nmodl_filename;
+extern void hoc_reg_nmodl_text(int, const char*);
+extern void hoc_reg_nmodl_filename(int, const char*);
+#endif
+
+ extern void _nrn_setdata_reg(int, void(*)(Prop*));
+ static void _setdata(Prop* _prop) {
+ _extcall_prop = _prop;
+ }
+ static void _hoc_setdata() {
+ Prop *_prop, *hoc_getdata_range(int);
+ _prop = hoc_getdata_range(_mechtype);
+   _setdata(_prop);
+ hoc_retpushx(1.);
+}
+ /* connect user functions to hoc names */
+ static VoidFunc hoc_intfunc[] = {
+ "setdata_slo1_egl19", _hoc_setdata,
+ "setparames_slo1_egl19", _hoc_setparames,
+ 0, 0
+};
+ /* declare global and static user variables */
+#define FARADAY FARADAY_slo1_egl19
+ double FARADAY = 96485;
+#define ath ath_slo1_egl19
+ double ath = 0.4;
+#define atm atm_slo1_egl19
+ double atm = 2.9;
+#define ahinf ahinf_slo1_egl19
+ double ahinf = 1.43;
+#define btot btot_slo1_egl19
+ double btot = 30;
+#define bth bth_slo1_egl19
+ double bth = 44.6;
+#define btm btm_slo1_egl19
+ double btm = 5.2;
+#define bhinf bhinf_slo1_egl19
+ double bhinf = 0.14;
+#define cth cth_slo1_egl19
+ double cth = -23;
+#define ctm ctm_slo1_egl19
+ double ctm = 6;
+#define chinf chinf_slo1_egl19
+ double chinf = 5.96;
+#define canci canci_slo1_egl19
+ double canci = 0.05;
+#define dca dca_slo1_egl19
+ double dca = 250;
+#define dth dth_slo1_egl19
+ double dth = 5;
+#define dtm dtm_slo1_egl19
+ double dtm = 1.9;
+#define dhinf dhinf_slo1_egl19
+ double dhinf = 0.6;
+#define eth eth_slo1_egl19
+ double eth = 36.4;
+#define etm etm_slo1_egl19
+ double etm = 1.4;
+#define fth fth_slo1_egl19
+ double fth = 28.7;
+#define ftm ftm_slo1_egl19
+ double ftm = 30;
+#define gsc gsc_slo1_egl19
+ double gsc = 0.04;
+#define gth gth_slo1_egl19
+ double gth = 3.7;
+#define gtm gtm_slo1_egl19
+ double gtm = 2.3;
+#define hth hth_slo1_egl19
+ double hth = 43.1;
+#define kb kb_slo1_egl19
+ double kb = 500;
+#define kib kib_slo1_egl19
+ double kib = 8.1;
+#define ki ki_slo1_egl19
+ double ki = 12;
+#define ka ka_slo1_egl19
+ double ka = 7.5;
+#define kyx kyx_slo1_egl19
+ double kyx = 34.34;
+#define kxy kxy_slo1_egl19
+ double kxy = 55.73;
+#define nyx nyx_slo1_egl19
+ double nyx = 0.0001;
+#define nxy nxy_slo1_egl19
+ double nxy = 1.3;
+#define r r_slo1_egl19
+ double r = 0.013;
+#define vhhb vhhb_slo1_egl19
+ double vhhb = -20.5;
+#define vhh vhh_slo1_egl19
+ double vhh = 24.9;
+#define vhm vhm_slo1_egl19
+ double vhm = 5.6;
+#define wop wop_slo1_egl19
+ double wop = 0.16;
+#define wom wom_slo1_egl19
+ double wom = 3.15;
+#define wxy wxy_slo1_egl19
+ double wxy = -0.028;
+#define wyx wyx_slo1_egl19
+ double wyx = 0.013;
+ /* some parameters have upper and lower limits */
+ static HocParmLimits _hoc_parm_limits[] = {
+ 0,0,0
+};
+ static HocParmUnits _hoc_parm_units[] = {
+ "wyx_slo1_egl19", "1/mV",
+ "wxy_slo1_egl19", "1/mV",
+ "wom_slo1_egl19", "1/ms",
+ "wop_slo1_egl19", "1/ms",
+ "kxy_slo1_egl19", "uM/um2",
+ "kyx_slo1_egl19", "uM/um2",
+ "canci_slo1_egl19", "uM/um2",
+ "vhm_slo1_egl19", "mV",
+ "ka_slo1_egl19", "mV",
+ "vhh_slo1_egl19", "mV",
+ "ki_slo1_egl19", "mV",
+ "vhhb_slo1_egl19", "mV",
+ "kib_slo1_egl19", "mV",
+ "atm_slo1_egl19", "ms",
+ "btm_slo1_egl19", "mV",
+ "ctm_slo1_egl19", "mV",
+ "dtm_slo1_egl19", "ms",
+ "etm_slo1_egl19", "mV",
+ "ftm_slo1_egl19", "mV",
+ "gtm_slo1_egl19", "ms",
+ "bth_slo1_egl19", "ms",
+ "cth_slo1_egl19", "mV",
+ "dth_slo1_egl19", "mV",
+ "eth_slo1_egl19", "ms",
+ "fth_slo1_egl19", "mV",
+ "gth_slo1_egl19", "mV",
+ "hth_slo1_egl19", "ms",
+ "FARADAY_slo1_egl19", "coul",
+ "gsc_slo1_egl19", "nS",
+ "r_slo1_egl19", "um",
+ "dca_slo1_egl19", "um2/s",
+ "kb_slo1_egl19", "1/uM/s",
+ "btot_slo1_egl19", "uM",
+ "gbslo1_slo1_egl19", "nS/um2",
+ "tm_slo1_egl19", "ms",
+ "tmcav_slo1_egl19", "ms",
+ "thcav_slo1_egl19", "ms",
+ 0,0
+};
+ static double delta_t = 0.01;
+ static double hcav0 = 0;
+ static double mcav0 = 0;
+ static double m0 = 0;
+ /* connect global user variables to hoc */
+ static DoubScal hoc_scdoub[] = {
+ "wyx_slo1_egl19", &wyx_slo1_egl19,
+ "wxy_slo1_egl19", &wxy_slo1_egl19,
+ "wom_slo1_egl19", &wom_slo1_egl19,
+ "wop_slo1_egl19", &wop_slo1_egl19,
+ "kxy_slo1_egl19", &kxy_slo1_egl19,
+ "nxy_slo1_egl19", &nxy_slo1_egl19,
+ "kyx_slo1_egl19", &kyx_slo1_egl19,
+ "nyx_slo1_egl19", &nyx_slo1_egl19,
+ "canci_slo1_egl19", &canci_slo1_egl19,
+ "vhm_slo1_egl19", &vhm_slo1_egl19,
+ "ka_slo1_egl19", &ka_slo1_egl19,
+ "vhh_slo1_egl19", &vhh_slo1_egl19,
+ "ki_slo1_egl19", &ki_slo1_egl19,
+ "vhhb_slo1_egl19", &vhhb_slo1_egl19,
+ "kib_slo1_egl19", &kib_slo1_egl19,
+ "ahinf_slo1_egl19", &ahinf_slo1_egl19,
+ "bhinf_slo1_egl19", &bhinf_slo1_egl19,
+ "chinf_slo1_egl19", &chinf_slo1_egl19,
+ "dhinf_slo1_egl19", &dhinf_slo1_egl19,
+ "atm_slo1_egl19", &atm_slo1_egl19,
+ "btm_slo1_egl19", &btm_slo1_egl19,
+ "ctm_slo1_egl19", &ctm_slo1_egl19,
+ "dtm_slo1_egl19", &dtm_slo1_egl19,
+ "etm_slo1_egl19", &etm_slo1_egl19,
+ "ftm_slo1_egl19", &ftm_slo1_egl19,
+ "gtm_slo1_egl19", &gtm_slo1_egl19,
+ "ath_slo1_egl19", &ath_slo1_egl19,
+ "bth_slo1_egl19", &bth_slo1_egl19,
+ "cth_slo1_egl19", &cth_slo1_egl19,
+ "dth_slo1_egl19", &dth_slo1_egl19,
+ "eth_slo1_egl19", &eth_slo1_egl19,
+ "fth_slo1_egl19", &fth_slo1_egl19,
+ "gth_slo1_egl19", &gth_slo1_egl19,
+ "hth_slo1_egl19", &hth_slo1_egl19,
+ "FARADAY_slo1_egl19", &FARADAY_slo1_egl19,
+ "gsc_slo1_egl19", &gsc_slo1_egl19,
+ "r_slo1_egl19", &r_slo1_egl19,
+ "dca_slo1_egl19", &dca_slo1_egl19,
+ "kb_slo1_egl19", &kb_slo1_egl19,
+ "btot_slo1_egl19", &btot_slo1_egl19,
+ 0,0
+};
+ static DoubVec hoc_vdoub[] = {
+ 0,0,0
+};
+ static double _sav_indep;
+ static void nrn_alloc(Prop*);
+static void  nrn_init(_NrnThread*, _Memb_list*, int);
+static void nrn_state(_NrnThread*, _Memb_list*, int);
+ static void nrn_cur(_NrnThread*, _Memb_list*, int);
+static void  nrn_jacob(_NrnThread*, _Memb_list*, int);
+ 
+static int _ode_count(int);
+static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
+static void _ode_spec(_NrnThread*, _Memb_list*, int);
+static void _ode_matsol(_NrnThread*, _Memb_list*, int);
+ 
+#define _cvode_ieq _ppvar[3]._i
+ static void _ode_matsol_instance1(_threadargsproto_);
+ /* connect range variables in _p that hoc is supposed to know about */
+ static const char *_mechanism[] = {
+ "7.7.0",
+"slo1_egl19",
+ "gbslo1_slo1_egl19",
+ 0,
+ "minf_slo1_egl19",
+ "tm_slo1_egl19",
+ "mcavinf_slo1_egl19",
+ "tmcav_slo1_egl19",
+ "hcavinf_slo1_egl19",
+ "thcav_slo1_egl19",
+ 0,
+ "m_slo1_egl19",
+ "hcav_slo1_egl19",
+ "mcav_slo1_egl19",
+ 0,
+ 0};
+ static Symbol* _k_sym;
+ 
+extern Prop* need_memb(Symbol*);
+
+static void nrn_alloc(Prop* _prop) {
+	Prop *prop_ion;
+	double *_p; Datum *_ppvar;
+ 	_p = nrn_prop_data_alloc(_mechtype, 17, _prop);
+ 	/*initialize range parameters*/
+ 	gbslo1 = 1;
+ 	_prop->param = _p;
+ 	_prop->param_size = 17;
+ 	_ppvar = nrn_prop_datum_alloc(_mechtype, 4, _prop);
+ 	_prop->dparam = _ppvar;
+ 	/*connect ionic variables to this model*/
+ prop_ion = need_memb(_k_sym);
+ nrn_promote(prop_ion, 0, 1);
+ 	_ppvar[0]._pval = &prop_ion->param[0]; /* ek */
+ 	_ppvar[1]._pval = &prop_ion->param[3]; /* ik */
+ 	_ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dikdv */
+ 
+}
+ static void _initlists();
+  /* some states have an absolute tolerance */
+ static Symbol** _atollist;
+ static HocStateTolerance _hoc_state_tol[] = {
+ 0,0
+};
+ static void _update_ion_pointer(Datum*);
+ extern Symbol* hoc_lookup(const char*);
+extern void _nrn_thread_reg(int, int, void(*)(Datum*));
+extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
+extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
+extern void _cvode_abstol( Symbol**, double*, int);
+
+ void _slo1_egl19_reg() {
+	int _vectorized = 1;
+  _initlists();
+ 	ion_reg("k", -10000.);
+ 	_k_sym = hoc_lookup("k_ion");
+ 	register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 1);
+ _mechtype = nrn_get_mechtype(_mechanism[1]);
+     _nrn_setdata_reg(_mechtype, _setdata);
+     _nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
+ #if NMODL_TEXT
+  hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
+  hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
+#endif
+  hoc_register_prop_size(_mechtype, 17, 4);
+  hoc_register_dparam_semantics(_mechtype, 0, "k_ion");
+  hoc_register_dparam_semantics(_mechtype, 1, "k_ion");
+  hoc_register_dparam_semantics(_mechtype, 2, "k_ion");
+  hoc_register_dparam_semantics(_mechtype, 3, "cvodeieq");
+ 	hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
+ 	hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
+ 	hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
+ 	ivoc_help("help ?1 slo1_egl19 /home/zjj/8TB/robot_arm/project/BAAIWorm_v1/eworm/components/mechanism/modfile/slo1_egl19.mod\n");
+ hoc_register_limits(_mechtype, _hoc_parm_limits);
+ hoc_register_units(_mechtype, _hoc_parm_units);
+ }
+static int _reset;
+static char *modelname = "slo1 current for C. elegans neuron model (suppose to interact with egl19)";
+
+static int error;
+static int _ninits = 0;
+static int _match_recurse=1;
+static void _modl_cleanup(){ _match_recurse=1;}
+static int setparames(_threadargsprotocomma_ double);
+ 
+static int _ode_spec1(_threadargsproto_);
+/*static int _ode_matsol1(_threadargsproto_);*/
+ static int _slist1[3], _dlist1[3];
+ static int states(_threadargsproto_);
+ 
+/*CVODE*/
+ static int _ode_spec1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {int _reset = 0; {
+   setparames ( _threadargscomma_ v ) ;
+   Dmcav = ( mcavinf - mcav ) / tmcav ;
+   Dhcav = ( hcavinf - hcav ) / thcav ;
+   Dm = ( minf - m ) / tm ;
+   }
+ return _reset;
+}
+ static int _ode_matsol1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
+ setparames ( _threadargscomma_ v ) ;
+ Dmcav = Dmcav  / (1. - dt*( ( ( ( - 1.0 ) ) ) / tmcav )) ;
+ Dhcav = Dhcav  / (1. - dt*( ( ( ( - 1.0 ) ) ) / thcav )) ;
+ Dm = Dm  / (1. - dt*( ( ( ( - 1.0 ) ) ) / tm )) ;
+  return 0;
+}
+ /*END CVODE*/
+ static int states (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) { {
+   setparames ( _threadargscomma_ v ) ;
+    mcav = mcav + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / tmcav)))*(- ( ( ( mcavinf ) ) / tmcav ) / ( ( ( ( - 1.0 ) ) ) / tmcav ) - mcav) ;
+    hcav = hcav + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / thcav)))*(- ( ( ( hcavinf ) ) / thcav ) / ( ( ( ( - 1.0 ) ) ) / thcav ) - hcav) ;
+    m = m + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / tm)))*(- ( ( ( minf ) ) / tm ) / ( ( ( ( - 1.0 ) ) ) / tm ) - m) ;
+   }
+  return 0;
+}
+ 
+static int  setparames ( _threadargsprotocomma_ double _lv ) {
+   double _lalpha , _lbeta , _lwm , _lwp , _lfm , _lfp , _lkom , _lkop , _lkcm , _lcain ;
+ mcavinf = 1.0 / ( 1.0 + exp ( - ( _lv - vhm ) / ka ) ) ;
+   hcavinf = ( ahinf / ( 1.0 + exp ( - ( _lv - vhh ) / ki ) ) + bhinf ) * ( chinf / ( 1.0 + exp ( ( _lv - vhhb ) / kib ) ) + dhinf ) ;
+   tmcav = atm * exp ( - pow( ( ( _lv - btm ) / ctm ) , 2.0 ) ) + dtm * exp ( - pow( ( ( _lv - etm ) / ftm ) , 2.0 ) ) + gtm ;
+   thcav = ath * ( ( bth / ( 1.0 + exp ( ( _lv - cth ) / dth ) ) ) + ( eth / ( 1.0 + exp ( ( _lv - fth ) / gth ) ) ) + hth ) ;
+   if ( _lv < 60.0 ) {
+     _lcain = - gsc * ( _lv - 60.0 ) * pow( 10.0 , 9.0 ) / ( 8.0 * 3.1415926 * r * dca * FARADAY ) * exp ( - r / sqrt ( dca / ( kb * btot ) ) ) ;
+     }
+   else {
+     _lcain = 0.0001 ;
+     }
+   _lalpha = mcavinf / tmcav ;
+   _lbeta = 1.0 / tmcav - _lalpha ;
+   _lwm = wom * exp ( - wyx * _lv ) ;
+   _lwp = wop * exp ( - wxy * _lv ) ;
+   _lfm = 1.0 / ( 1.0 + pow( ( _lcain / kyx ) , nyx ) ) ;
+   _lfp = 1.0 / ( 1.0 + pow( ( kxy / _lcain ) , nxy ) ) ;
+   _lkom = _lwm * _lfm ;
+   _lkop = _lwp * _lfp ;
+   _lkcm = _lwm * 1.0 / ( 1.0 + pow( ( canci / kyx ) , nyx ) ) ;
+   minf = mcav * _lkop * ( _lalpha + _lbeta + _lkcm ) / ( ( _lkop + _lkom ) * ( _lkcm + _lalpha ) + _lbeta * _lkcm ) ;
+   tm = ( _lalpha + _lbeta + _lkcm ) / ( ( _lkop + _lkom ) * ( _lkcm + _lalpha ) + _lbeta * _lkcm ) ;
+    return 0; }
+ 
+static void _hoc_setparames(void) {
+  double _r;
+   double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
+   if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
+  _thread = _extcall_thread;
+  _nt = nrn_threads;
+ _r = 1.;
+ setparames ( _p, _ppvar, _thread, _nt, *getarg(1) );
+ hoc_retpushx(_r);
+}
+ 
+static int _ode_count(int _type){ return 3;}
+ 
+static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
+   double* _p; Datum* _ppvar; Datum* _thread;
+   Node* _nd; double _v; int _iml, _cntml;
+  _cntml = _ml->_nodecount;
+  _thread = _ml->_thread;
+  for (_iml = 0; _iml < _cntml; ++_iml) {
+    _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
+    _nd = _ml->_nodelist[_iml];
+    v = NODEV(_nd);
+  ek = _ion_ek;
+     _ode_spec1 (_p, _ppvar, _thread, _nt);
+  }}
+ 
+static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) { 
+	double* _p; Datum* _ppvar;
+ 	int _i; _p = _pp; _ppvar = _ppd;
+	_cvode_ieq = _ieq;
+	for (_i=0; _i < 3; ++_i) {
+		_pv[_i] = _pp + _slist1[_i];  _pvdot[_i] = _pp + _dlist1[_i];
+		_cvode_abstol(_atollist, _atol, _i);
+	}
+ }
+ 
+static void _ode_matsol_instance1(_threadargsproto_) {
+ _ode_matsol1 (_p, _ppvar, _thread, _nt);
+ }
+ 
+static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
+   double* _p; Datum* _ppvar; Datum* _thread;
+   Node* _nd; double _v; int _iml, _cntml;
+  _cntml = _ml->_nodecount;
+  _thread = _ml->_thread;
+  for (_iml = 0; _iml < _cntml; ++_iml) {
+    _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
+    _nd = _ml->_nodelist[_iml];
+    v = NODEV(_nd);
+  ek = _ion_ek;
+ _ode_matsol_instance1(_threadargs_);
+ }}
+ extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
+ static void _update_ion_pointer(Datum* _ppvar) {
+   nrn_update_ion_pointer(_k_sym, _ppvar, 0, 0);
+   nrn_update_ion_pointer(_k_sym, _ppvar, 1, 3);
+   nrn_update_ion_pointer(_k_sym, _ppvar, 2, 4);
+ }
+
+static void initmodel(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
+  int _i; double _save;{
+  hcav = hcav0;
+  mcav = mcav0;
+  m = m0;
+ {
+   setparames ( _threadargscomma_ v ) ;
+   hcav = hcavinf ;
+   mcav = mcavinf ;
+   m = 0.0 ;
+   }
+ 
+}
+}
+
+static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
+double* _p; Datum* _ppvar; Datum* _thread;
+Node *_nd; double _v; int* _ni; int _iml, _cntml;
+#if CACHEVEC
+    _ni = _ml->_nodeindices;
+#endif
+_cntml = _ml->_nodecount;
+_thread = _ml->_thread;
+for (_iml = 0; _iml < _cntml; ++_iml) {
+ _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
+#if CACHEVEC
+  if (use_cachevec) {
+    _v = VEC_V(_ni[_iml]);
+  }else
+#endif
+  {
+    _nd = _ml->_nodelist[_iml];
+    _v = NODEV(_nd);
+  }
+ v = _v;
+  ek = _ion_ek;
+ initmodel(_p, _ppvar, _thread, _nt);
+ }
+}
+
+static double _nrn_current(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, double _v){double _current=0.;v=_v;{ {
+   ik = gbslo1 * m * hcav * ( v + 80.0 ) ;
+   }
+ _current += ik;
+
+} return _current;
+}
+
+static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type) {
+double* _p; Datum* _ppvar; Datum* _thread;
+Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
+#if CACHEVEC
+    _ni = _ml->_nodeindices;
+#endif
+_cntml = _ml->_nodecount;
+_thread = _ml->_thread;
+for (_iml = 0; _iml < _cntml; ++_iml) {
+ _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
+#if CACHEVEC
+  if (use_cachevec) {
+    _v = VEC_V(_ni[_iml]);
+  }else
+#endif
+  {
+    _nd = _ml->_nodelist[_iml];
+    _v = NODEV(_nd);
+  }
+  ek = _ion_ek;
+ _g = _nrn_current(_p, _ppvar, _thread, _nt, _v + .001);
+ 	{ double _dik;
+  _dik = ik;
+ _rhs = _nrn_current(_p, _ppvar, _thread, _nt, _v);
+  _ion_dikdv += (_dik - ik)/.001 ;
+ 	}
+ _g = (_g - _rhs)/.001;
+  _ion_ik += ik ;
+#if CACHEVEC
+  if (use_cachevec) {
+	VEC_RHS(_ni[_iml]) -= _rhs;
+  }else
+#endif
+  {
+	NODERHS(_nd) -= _rhs;
+  }
+ 
+}
+ 
+}
+
+static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type) {
+double* _p; Datum* _ppvar; Datum* _thread;
+Node *_nd; int* _ni; int _iml, _cntml;
+#if CACHEVEC
+    _ni = _ml->_nodeindices;
+#endif
+_cntml = _ml->_nodecount;
+_thread = _ml->_thread;
+for (_iml = 0; _iml < _cntml; ++_iml) {
+ _p = _ml->_data[_iml];
+#if CACHEVEC
+  if (use_cachevec) {
+	VEC_D(_ni[_iml]) += _g;
+  }else
+#endif
+  {
+     _nd = _ml->_nodelist[_iml];
+	NODED(_nd) += _g;
+  }
+ 
+}
+ 
+}
+
+static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type) {
+double* _p; Datum* _ppvar; Datum* _thread;
+Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
+#if CACHEVEC
+    _ni = _ml->_nodeindices;
+#endif
+_cntml = _ml->_nodecount;
+_thread = _ml->_thread;
+for (_iml = 0; _iml < _cntml; ++_iml) {
+ _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
+ _nd = _ml->_nodelist[_iml];
+#if CACHEVEC
+  if (use_cachevec) {
+    _v = VEC_V(_ni[_iml]);
+  }else
+#endif
+  {
+    _nd = _ml->_nodelist[_iml];
+    _v = NODEV(_nd);
+  }
+ v=_v;
+{
+  ek = _ion_ek;
+ {   states(_p, _ppvar, _thread, _nt);
+  } }}
+
+}
+
+static void terminal(){}
+
+static void _initlists(){
+ double _x; double* _p = &_x;
+ int _i; static int _first = 1;
+  if (!_first) return;
+ _slist1[0] = &(mcav) - _p;  _dlist1[0] = &(Dmcav) - _p;
+ _slist1[1] = &(hcav) - _p;  _dlist1[1] = &(Dhcav) - _p;
+ _slist1[2] = &(m) - _p;  _dlist1[2] = &(Dm) - _p;
+_first = 0;
+}
+
+#if defined(__cplusplus)
+} /* extern "C" */
+#endif
+
+#if NMODL_TEXT
+static const char* nmodl_filename = "/home/zjj/8TB/robot_arm/project/BAAIWorm_v1/eworm/components/mechanism/modfile/slo1_egl19.mod";
+static const char* nmodl_file_text = 
+  "TITLE slo1 current for C. elegans neuron model (suppose to interact with egl19)\n"
+  "\n"
+  "\n"
+  "COMMENT\n"
+  "channel type: calcium-related potassium channel\n"
+  "\n"
+  "slo1-egl19 1:1 stoichiometry\n"
+  "\n"
+  "model and parameters from:\n"
+  "Nicoletti, M., et al. (2019). \"Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD.\" PLoS One 14(7): e0218738.\n"
+  "ENDCOMMENT\n"
+  "\n"
+  "\n"
+  "UNITS {\n"
+  "    (nS) = (nanosiemens)\n"
+  "    (mV) = (millivolt)\n"
+  "    (pA) = (picoamp)\n"
+  "    (um) = (micron)\n"
+  "    (molar) = (1/liter)  : moles do not appear in units\n"
+  "    (uM) = (micromolar)\n"
+  "}\n"
+  "\n"
+  "\n"
+  "NEURON {\n"
+  "    SUFFIX slo1_egl19\n"
+  "    USEION k READ ek WRITE ik\n"
+  "    RANGE gbslo1, minf, tm, mcavinf, tmcav, hcavinf, thcav, m, hcav, mcav\n"
+  "}\n"
+  "\n"
+  "\n"
+  "PARAMETER {\n"
+  "    : slo1\n"
+  "    gbslo1 = 1 (nS/um2)\n"
+  "    wyx = 0.013 (1/mV)\n"
+  "    wxy = -0.028 (1/mV)\n"
+  "    wom = 3.15 (1/ms)\n"
+  "    wop = 0.16 (1/ms)\n"
+  "    kxy = 55.73 (uM/um2)\n"
+  "    nxy = 1.30\n"
+  "    kyx = 34.34 (uM/um2)\n"
+  "    nyx = 0.0001\n"
+  "    canci = 0.05 (uM/um2) : calcium concentration When the calcium channel is closed\n"
+  "\n"
+  "    : egl19\n"
+  "    vhm = 5.6 (mV)\n"
+  "    ka = 7.5 (mV)\n"
+  "    vhh = 24.9 (mV)\n"
+  "    ki = 12.0 (mV)\n"
+  "    vhhb = -20.5 (mV)\n"
+  "    kib = 8.1 (mV)\n"
+  "    ahinf = 1.43\n"
+  "    bhinf = 0.14\n"
+  "    chinf = 5.96\n"
+  "    dhinf = 0.60\n"
+  "    atm = 2.9 (ms)\n"
+  "    btm = 5.2 (mV)\n"
+  "    ctm = 6.0 (mV)\n"
+  "    dtm = 1.9 (ms)\n"
+  "    etm = 1.4 (mV)\n"
+  "    ftm = 30.0 (mV)\n"
+  "    gtm = 2.3 (ms)\n"
+  "    ath = 0.4\n"
+  "    bth = 44.6 (ms)\n"
+  "    cth = -23.0 (mV)\n"
+  "    dth = 5.0 (mV)\n"
+  "    eth = 36.4 (ms)\n"
+  "    fth = 28.7 (mV)\n"
+  "    gth = 3.7 (mV)\n"
+  "    hth = 43.1 (ms)\n"
+  "\n"
+  "    : cain\n"
+  "    FARADAY = 96485 (coul) : moles do not appear in units\n"
+  "	gsc = 0.04 (nS)   : single channel conductance, assumed equal to 40 pS for both L-type and P/Qtype calcium channels\n"
+  "    r = 0.013 (um)       : radius of the nanodomain\n"
+  "    dca = 250 (um2/s) : calcium diffusion coefficient\n"
+  "    kb = 500 (1/uM/s) : intracellular buffer rate constant\n"
+  "    btot = 30 (uM)    : total intracellular buffer concentration\n"
+  "}\n"
+  "\n"
+  "\n"
+  "ASSIGNED {\n"
+  "    v (mV)\n"
+  "    ek (mV)\n"
+  "    ik (pA/um2)\n"
+  "    minf\n"
+  "    tm (ms)\n"
+  "    mcavinf\n"
+  "    tmcav (ms)\n"
+  "    hcavinf\n"
+  "    thcav (ms)\n"
+  "}\n"
+  "\n"
+  "\n"
+  "STATE {\n"
+  "    m\n"
+  "    hcav\n"
+  "    mcav\n"
+  "}\n"
+  "\n"
+  "\n"
+  "BREAKPOINT {\n"
+  "    SOLVE states METHOD cnexp\n"
+  "    ik = gbslo1 * m * hcav * (v + 80) : ek=-80\n"
+  "}\n"
+  "\n"
+  "\n"
+  "INITIAL {\n"
+  "    setparames(v)\n"
+  "    hcav = hcavinf\n"
+  "    mcav = mcavinf\n"
+  "    m = 0\n"
+  "}\n"
+  "\n"
+  "\n"
+  "DERIVATIVE states {\n"
+  "    setparames(v)\n"
+  "    mcav' = (mcavinf - mcav) / tmcav\n"
+  "    hcav' = (hcavinf - hcav) / thcav\n"
+  "    m' = (minf - m) / tm    \n"
+  "}\n"
+  "\n"
+  "\n"
+  "PROCEDURE setparames(v (mV)) {\n"
+  "    LOCAL alpha, beta, wm, wp, fm, fp, kom, kop, kcm, cain\n"
+  "    : egl19 model\n"
+  "    mcavinf = 1 / (1 + exp(-(v - vhm) / ka))\n"
+  "    hcavinf = (ahinf / (1 + exp(-(v - vhh) / ki)) + bhinf) * (chinf / (1 + exp((v - vhhb) / kib)) + dhinf)\n"
+  "    tmcav = atm * exp(-((v - btm) / ctm) ^ 2) + dtm * exp(-((v - etm) / ftm) ^ 2) + gtm\n"
+  "    thcav = ath * ((bth / (1 + exp((v - cth) / dth))) + (eth / (1 + exp((v - fth) / gth))) + hth)\n"
+  "    : cain\n"
+  "    if (v < 60) {\n"
+  "        cain = -gsc * (v - 60) * 10^9 / (8 * 3.1415926 * r * dca * FARADAY) * exp (-r / sqrt(dca / (kb * btot)))\n"
+  "    } else {\n"
+  "        cain = 0.0001\n"
+  "    }\n"
+  "    : slo1-egl19 model\n"
+  "    alpha = mcavinf / tmcav\n"
+  "    beta = 1 / tmcav - alpha\n"
+  "    wm = wom * exp(-wyx * v)\n"
+  "    wp = wop * exp(-wxy * v)\n"
+  "    fm = 1 / (1 + (cain / kyx) ^ nyx)\n"
+  "    fp = 1 / (1 + (kxy / cain) ^ nxy)\n"
+  "    kom = wm * fm\n"
+  "    kop = wp * fp\n"
+  "    kcm = wm * 1 / (1 + (canci / kyx) ^ nyx)\n"
+  "    minf = mcav * kop * (alpha + beta + kcm) / ((kop + kom) * (kcm + alpha) + beta * kcm)\n"
+  "    tm = (alpha + beta + kcm) / ((kop + kom) * (kcm + alpha) + beta * kcm)\n"
+  "}\n"
+  ;
+#endif