tooluniverse 1.0.9.1__py3-none-any.whl → 1.0.11__py3-none-any.whl
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- tooluniverse/__init__.py +57 -1
- tooluniverse/admetai_tool.py +1 -1
- tooluniverse/agentic_tool.py +65 -17
- tooluniverse/base_tool.py +19 -8
- tooluniverse/blast_tool.py +132 -0
- tooluniverse/boltz_tool.py +3 -3
- tooluniverse/cache/result_cache_manager.py +167 -12
- tooluniverse/cbioportal_tool.py +42 -0
- tooluniverse/clinvar_tool.py +268 -74
- tooluniverse/compose_scripts/drug_safety_analyzer.py +1 -1
- tooluniverse/compose_scripts/multi_agent_literature_search.py +1 -1
- tooluniverse/compose_scripts/output_summarizer.py +4 -4
- tooluniverse/compose_scripts/tool_discover.py +1941 -443
- tooluniverse/compose_scripts/tool_graph_composer.py +1 -1
- tooluniverse/compose_scripts/tool_metadata_generator.py +1 -1
- tooluniverse/compose_tool.py +9 -9
- tooluniverse/core_tool.py +2 -2
- tooluniverse/ctg_tool.py +4 -4
- tooluniverse/custom_tool.py +1 -1
- tooluniverse/data/agentic_tools.json +0 -370
- tooluniverse/data/alphafold_tools.json +6 -6
- tooluniverse/data/blast_tools.json +112 -0
- tooluniverse/data/cbioportal_tools.json +87 -0
- tooluniverse/data/clinvar_tools.json +235 -0
- tooluniverse/data/compose_tools.json +0 -89
- tooluniverse/data/dbsnp_tools.json +275 -0
- tooluniverse/data/emdb_tools.json +61 -0
- tooluniverse/data/ensembl_tools.json +259 -0
- tooluniverse/data/file_download_tools.json +275 -0
- tooluniverse/data/geo_tools.json +200 -48
- tooluniverse/data/gnomad_tools.json +109 -0
- tooluniverse/data/gtopdb_tools.json +68 -0
- tooluniverse/data/gwas_tools.json +32 -0
- tooluniverse/data/interpro_tools.json +199 -0
- tooluniverse/data/jaspar_tools.json +70 -0
- tooluniverse/data/kegg_tools.json +356 -0
- tooluniverse/data/mpd_tools.json +87 -0
- tooluniverse/data/ols_tools.json +314 -0
- tooluniverse/data/package_discovery_tools.json +64 -0
- tooluniverse/data/packages/categorized_tools.txt +0 -1
- tooluniverse/data/packages/machine_learning_tools.json +0 -47
- tooluniverse/data/paleobiology_tools.json +91 -0
- tooluniverse/data/pride_tools.json +62 -0
- tooluniverse/data/pypi_package_inspector_tools.json +158 -0
- tooluniverse/data/python_executor_tools.json +341 -0
- tooluniverse/data/regulomedb_tools.json +50 -0
- tooluniverse/data/remap_tools.json +89 -0
- tooluniverse/data/screen_tools.json +89 -0
- tooluniverse/data/tool_discovery_agents.json +428 -0
- tooluniverse/data/tool_discovery_agents.json.backup +1343 -0
- tooluniverse/data/uniprot_tools.json +77 -0
- tooluniverse/data/web_search_tools.json +250 -0
- tooluniverse/data/worms_tools.json +55 -0
- tooluniverse/dataset_tool.py +2 -2
- tooluniverse/dbsnp_tool.py +196 -58
- tooluniverse/default_config.py +36 -3
- tooluniverse/emdb_tool.py +30 -0
- tooluniverse/enrichr_tool.py +14 -14
- tooluniverse/ensembl_tool.py +140 -47
- tooluniverse/execute_function.py +594 -29
- tooluniverse/extended_hooks.py +4 -4
- tooluniverse/file_download_tool.py +269 -0
- tooluniverse/gene_ontology_tool.py +1 -1
- tooluniverse/generate_tools.py +3 -3
- tooluniverse/geo_tool.py +81 -28
- tooluniverse/gnomad_tool.py +100 -52
- tooluniverse/gtopdb_tool.py +41 -0
- tooluniverse/humanbase_tool.py +10 -10
- tooluniverse/interpro_tool.py +72 -0
- tooluniverse/jaspar_tool.py +30 -0
- tooluniverse/kegg_tool.py +230 -0
- tooluniverse/logging_config.py +2 -2
- tooluniverse/mcp_client_tool.py +57 -129
- tooluniverse/mcp_integration.py +52 -49
- tooluniverse/mcp_tool_registry.py +147 -528
- tooluniverse/mpd_tool.py +42 -0
- tooluniverse/ncbi_eutils_tool.py +96 -0
- tooluniverse/ols_tool.py +435 -0
- tooluniverse/openalex_tool.py +8 -8
- tooluniverse/openfda_tool.py +2 -2
- tooluniverse/output_hook.py +15 -15
- tooluniverse/package_discovery_tool.py +217 -0
- tooluniverse/package_tool.py +1 -1
- tooluniverse/paleobiology_tool.py +30 -0
- tooluniverse/pmc_tool.py +2 -2
- tooluniverse/pride_tool.py +30 -0
- tooluniverse/pypi_package_inspector_tool.py +593 -0
- tooluniverse/python_executor_tool.py +711 -0
- tooluniverse/regulomedb_tool.py +30 -0
- tooluniverse/remap_tool.py +44 -0
- tooluniverse/remote/boltz/boltz_mcp_server.py +1 -1
- tooluniverse/remote/depmap_24q2/depmap_24q2_mcp_tool.py +3 -3
- tooluniverse/remote/immune_compass/compass_tool.py +3 -3
- tooluniverse/remote/pinnacle/pinnacle_tool.py +2 -2
- tooluniverse/remote/transcriptformer/transcriptformer_tool.py +3 -3
- tooluniverse/remote/uspto_downloader/uspto_downloader_mcp_server.py +3 -3
- tooluniverse/remote_tool.py +4 -4
- tooluniverse/screen_tool.py +44 -0
- tooluniverse/scripts/filter_tool_files.py +2 -2
- tooluniverse/smcp.py +93 -12
- tooluniverse/smcp_server.py +100 -21
- tooluniverse/space/__init__.py +46 -0
- tooluniverse/space/loader.py +133 -0
- tooluniverse/space/validator.py +353 -0
- tooluniverse/tool_finder_embedding.py +5 -3
- tooluniverse/tool_finder_keyword.py +12 -10
- tooluniverse/tool_finder_llm.py +12 -8
- tooluniverse/tools/{UCSC_get_genes_by_region.py → BLAST_nucleotide_search.py} +22 -26
- tooluniverse/tools/BLAST_protein_search.py +63 -0
- tooluniverse/tools/ClinVar_search_variants.py +26 -15
- tooluniverse/tools/CodeQualityAnalyzer.py +3 -3
- tooluniverse/tools/EMDB_get_structure.py +46 -0
- tooluniverse/tools/GtoPdb_get_targets.py +52 -0
- tooluniverse/tools/InterPro_get_domain_details.py +46 -0
- tooluniverse/tools/InterPro_get_protein_domains.py +49 -0
- tooluniverse/tools/InterPro_search_domains.py +52 -0
- tooluniverse/tools/JASPAR_get_transcription_factors.py +52 -0
- tooluniverse/tools/MPD_get_phenotype_data.py +59 -0
- tooluniverse/tools/PRIDE_search_proteomics.py +52 -0
- tooluniverse/tools/PackageAnalyzer.py +55 -0
- tooluniverse/tools/Paleobiology_get_fossils.py +52 -0
- tooluniverse/tools/PyPIPackageInspector.py +59 -0
- tooluniverse/tools/ReMap_get_transcription_factor_binding.py +59 -0
- tooluniverse/tools/ReferenceInfoAnalyzer.py +55 -0
- tooluniverse/tools/RegulomeDB_query_variant.py +46 -0
- tooluniverse/tools/SCREEN_get_regulatory_elements.py +59 -0
- tooluniverse/tools/{ArgumentDescriptionOptimizer.py → TestResultsAnalyzer.py} +13 -13
- tooluniverse/tools/ToolDiscover.py +11 -11
- tooluniverse/tools/UniProt_id_mapping.py +63 -0
- tooluniverse/tools/UniProt_search.py +63 -0
- tooluniverse/tools/UnifiedToolGenerator.py +59 -0
- tooluniverse/tools/WoRMS_search_species.py +49 -0
- tooluniverse/tools/XMLToolOptimizer.py +55 -0
- tooluniverse/tools/__init__.py +119 -29
- tooluniverse/tools/_shared_client.py +3 -3
- tooluniverse/tools/alphafold_get_annotations.py +3 -3
- tooluniverse/tools/alphafold_get_prediction.py +3 -3
- tooluniverse/tools/alphafold_get_summary.py +3 -3
- tooluniverse/tools/cBioPortal_get_cancer_studies.py +46 -0
- tooluniverse/tools/cBioPortal_get_mutations.py +52 -0
- tooluniverse/tools/{gnomAD_query_variant.py → clinvar_get_clinical_significance.py} +8 -11
- tooluniverse/tools/clinvar_get_variant_details.py +49 -0
- tooluniverse/tools/dbSNP_get_variant_by_rsid.py +7 -7
- tooluniverse/tools/dbsnp_get_frequencies.py +46 -0
- tooluniverse/tools/dbsnp_search_by_gene.py +52 -0
- tooluniverse/tools/download_binary_file.py +66 -0
- tooluniverse/tools/download_file.py +71 -0
- tooluniverse/tools/download_text_content.py +55 -0
- tooluniverse/tools/dynamic_package_discovery.py +59 -0
- tooluniverse/tools/ensembl_get_sequence.py +52 -0
- tooluniverse/tools/{Ensembl_lookup_gene_by_symbol.py → ensembl_get_variants.py} +11 -11
- tooluniverse/tools/ensembl_lookup_gene.py +46 -0
- tooluniverse/tools/geo_get_dataset_info.py +46 -0
- tooluniverse/tools/geo_get_sample_info.py +46 -0
- tooluniverse/tools/geo_search_datasets.py +67 -0
- tooluniverse/tools/gnomad_get_gene_constraints.py +49 -0
- tooluniverse/tools/kegg_find_genes.py +52 -0
- tooluniverse/tools/kegg_get_gene_info.py +46 -0
- tooluniverse/tools/kegg_get_pathway_info.py +46 -0
- tooluniverse/tools/kegg_list_organisms.py +44 -0
- tooluniverse/tools/kegg_search_pathway.py +46 -0
- tooluniverse/tools/ols_find_similar_terms.py +63 -0
- tooluniverse/tools/{get_hyperopt_info.py → ols_get_ontology_info.py} +13 -10
- tooluniverse/tools/ols_get_term_ancestors.py +67 -0
- tooluniverse/tools/ols_get_term_children.py +67 -0
- tooluniverse/tools/{TestCaseGenerator.py → ols_get_term_info.py} +12 -9
- tooluniverse/tools/{CodeOptimizer.py → ols_search_ontologies.py} +22 -14
- tooluniverse/tools/ols_search_terms.py +71 -0
- tooluniverse/tools/python_code_executor.py +79 -0
- tooluniverse/tools/python_script_runner.py +79 -0
- tooluniverse/tools/web_api_documentation_search.py +63 -0
- tooluniverse/tools/web_search.py +71 -0
- tooluniverse/uniprot_tool.py +219 -16
- tooluniverse/url_tool.py +19 -1
- tooluniverse/uspto_tool.py +1 -1
- tooluniverse/utils.py +12 -12
- tooluniverse/web_search_tool.py +229 -0
- tooluniverse/worms_tool.py +64 -0
- {tooluniverse-1.0.9.1.dist-info → tooluniverse-1.0.11.dist-info}/METADATA +8 -3
- {tooluniverse-1.0.9.1.dist-info → tooluniverse-1.0.11.dist-info}/RECORD +184 -92
- tooluniverse/data/genomics_tools.json +0 -174
- tooluniverse/tools/ToolDescriptionOptimizer.py +0 -67
- tooluniverse/tools/ToolImplementationGenerator.py +0 -67
- tooluniverse/tools/ToolOptimizer.py +0 -59
- tooluniverse/tools/ToolSpecificationGenerator.py +0 -67
- tooluniverse/tools/ToolSpecificationOptimizer.py +0 -63
- tooluniverse/ucsc_tool.py +0 -60
- {tooluniverse-1.0.9.1.dist-info → tooluniverse-1.0.11.dist-info}/WHEEL +0 -0
- {tooluniverse-1.0.9.1.dist-info → tooluniverse-1.0.11.dist-info}/entry_points.txt +0 -0
- {tooluniverse-1.0.9.1.dist-info → tooluniverse-1.0.11.dist-info}/licenses/LICENSE +0 -0
- {tooluniverse-1.0.9.1.dist-info → tooluniverse-1.0.11.dist-info}/top_level.txt +0 -0
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"description": "Download files from HTTP/HTTPS URLs with cross-platform support (Windows, Mac, Linux). Similar to curl but platform-independent. Can save to specified path or temporary directory.",
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"description": "HTTP or HTTPS URL to download from (e.g., https://example.com/file.txt)",
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"description": "Content-Length header value"
|
|
177
|
+
},
|
|
178
|
+
"url": {
|
|
179
|
+
"type": "string",
|
|
180
|
+
"description": "Original URL"
|
|
181
|
+
},
|
|
182
|
+
"status_code": {
|
|
183
|
+
"type": "integer",
|
|
184
|
+
"description": "HTTP status code"
|
|
185
|
+
}
|
|
186
|
+
}
|
|
187
|
+
},
|
|
188
|
+
{
|
|
189
|
+
"type": "object",
|
|
190
|
+
"description": "Error response",
|
|
191
|
+
"properties": {
|
|
192
|
+
"error": {
|
|
193
|
+
"type": "string",
|
|
194
|
+
"description": "Error message"
|
|
195
|
+
}
|
|
196
|
+
}
|
|
197
|
+
}
|
|
198
|
+
]
|
|
199
|
+
}
|
|
200
|
+
},
|
|
201
|
+
{
|
|
202
|
+
"type": "TextDownloadTool",
|
|
203
|
+
"name": "download_text_content",
|
|
204
|
+
"description": "Download and return text content from URLs. Optimized for text files with automatic encoding detection.",
|
|
205
|
+
"fields": {
|
|
206
|
+
"return_key": "content"
|
|
207
|
+
},
|
|
208
|
+
"parameter": {
|
|
209
|
+
"type": "object",
|
|
210
|
+
"required": [
|
|
211
|
+
"url"
|
|
212
|
+
],
|
|
213
|
+
"additionalProperties": false,
|
|
214
|
+
"properties": {
|
|
215
|
+
"url": {
|
|
216
|
+
"type": "string",
|
|
217
|
+
"description": "HTTP or HTTPS URL to download text from",
|
|
218
|
+
"format": "uri"
|
|
219
|
+
},
|
|
220
|
+
"encoding": {
|
|
221
|
+
"type": "string",
|
|
222
|
+
"description": "Text encoding (e.g., utf-8, latin1). Auto-detected if not specified.",
|
|
223
|
+
"example": "utf-8"
|
|
224
|
+
},
|
|
225
|
+
"timeout": {
|
|
226
|
+
"type": "integer",
|
|
227
|
+
"description": "Request timeout in seconds",
|
|
228
|
+
"minimum": 1,
|
|
229
|
+
"maximum": 300,
|
|
230
|
+
"default": 30
|
|
231
|
+
}
|
|
232
|
+
}
|
|
233
|
+
},
|
|
234
|
+
"return_schema": {
|
|
235
|
+
"oneOf": [
|
|
236
|
+
{
|
|
237
|
+
"type": "object",
|
|
238
|
+
"description": "Successfully downloaded text content",
|
|
239
|
+
"properties": {
|
|
240
|
+
"content": {
|
|
241
|
+
"type": "string",
|
|
242
|
+
"description": "Text content from the URL"
|
|
243
|
+
},
|
|
244
|
+
"encoding": {
|
|
245
|
+
"type": "string",
|
|
246
|
+
"description": "Detected or specified encoding"
|
|
247
|
+
},
|
|
248
|
+
"size": {
|
|
249
|
+
"type": "integer",
|
|
250
|
+
"description": "Size of content in characters"
|
|
251
|
+
},
|
|
252
|
+
"url": {
|
|
253
|
+
"type": "string",
|
|
254
|
+
"description": "Original URL"
|
|
255
|
+
},
|
|
256
|
+
"content_type": {
|
|
257
|
+
"type": "string",
|
|
258
|
+
"description": "MIME type of the content"
|
|
259
|
+
}
|
|
260
|
+
}
|
|
261
|
+
},
|
|
262
|
+
{
|
|
263
|
+
"type": "object",
|
|
264
|
+
"description": "Error response",
|
|
265
|
+
"properties": {
|
|
266
|
+
"error": {
|
|
267
|
+
"type": "string",
|
|
268
|
+
"description": "Error message"
|
|
269
|
+
}
|
|
270
|
+
}
|
|
271
|
+
}
|
|
272
|
+
]
|
|
273
|
+
}
|
|
274
|
+
}
|
|
275
|
+
]
|
tooluniverse/data/geo_tools.json
CHANGED
|
@@ -1,49 +1,39 @@
|
|
|
1
1
|
[
|
|
2
2
|
{
|
|
3
|
-
"type": "
|
|
4
|
-
"name": "
|
|
5
|
-
"description": "Search
|
|
3
|
+
"type": "GEOSearchDatasets",
|
|
4
|
+
"name": "geo_search_datasets",
|
|
5
|
+
"description": "Search GEO datasets by query terms, organism, study type, or platform. Returns dataset IDs and basic information.",
|
|
6
6
|
"parameter": {
|
|
7
7
|
"type": "object",
|
|
8
8
|
"properties": {
|
|
9
9
|
"query": {
|
|
10
10
|
"type": "string",
|
|
11
|
-
"description": "Search query (e.g., 'cancer', 'diabetes', 'microarray')"
|
|
12
|
-
"minLength": 1
|
|
11
|
+
"description": "Search query terms (e.g., 'cancer', 'diabetes', 'microarray')"
|
|
13
12
|
},
|
|
14
13
|
"organism": {
|
|
15
14
|
"type": "string",
|
|
16
15
|
"description": "Organism name (e.g., 'Homo sapiens', 'Mus musculus')",
|
|
17
|
-
"default": "
|
|
16
|
+
"default": ""
|
|
18
17
|
},
|
|
19
18
|
"study_type": {
|
|
20
19
|
"type": "string",
|
|
21
|
-
"description": "Type of study (e.g., '
|
|
22
|
-
"
|
|
20
|
+
"description": "Type of study (e.g., 'Expression profiling by array', 'Expression profiling by high throughput sequencing')",
|
|
21
|
+
"default": ""
|
|
23
22
|
},
|
|
24
23
|
"platform": {
|
|
25
24
|
"type": "string",
|
|
26
|
-
"description": "Platform used (e.g., '
|
|
27
|
-
|
|
28
|
-
"date_range": {
|
|
29
|
-
"type": "string",
|
|
30
|
-
"description": "Date range in format 'YYYY:YYYY' (e.g., '2020:2023')"
|
|
25
|
+
"description": "Platform used (e.g., 'GPL570', 'GPL96')",
|
|
26
|
+
"default": ""
|
|
31
27
|
},
|
|
32
28
|
"limit": {
|
|
33
29
|
"type": "integer",
|
|
34
|
-
"description": "Maximum number of results to return
|
|
30
|
+
"description": "Maximum number of results to return",
|
|
31
|
+
"default": 50,
|
|
35
32
|
"minimum": 1,
|
|
36
|
-
"maximum": 500
|
|
37
|
-
"default": 50
|
|
38
|
-
},
|
|
39
|
-
"sort": {
|
|
40
|
-
"type": "string",
|
|
41
|
-
"description": "Sort order ('relevance', 'date', 'title')",
|
|
42
|
-
"enum": ["relevance", "date", "title"],
|
|
43
|
-
"default": "relevance"
|
|
33
|
+
"maximum": 500
|
|
44
34
|
}
|
|
45
35
|
},
|
|
46
|
-
"required": [
|
|
36
|
+
"required": []
|
|
47
37
|
},
|
|
48
38
|
"fields": {
|
|
49
39
|
"endpoint": "/esearch.fcgi",
|
|
@@ -51,36 +41,198 @@
|
|
|
51
41
|
},
|
|
52
42
|
"return_schema": {
|
|
53
43
|
"type": "object",
|
|
44
|
+
"description": "GEO dataset search results",
|
|
54
45
|
"properties": {
|
|
55
|
-
"
|
|
56
|
-
|
|
57
|
-
|
|
58
|
-
|
|
59
|
-
|
|
60
|
-
|
|
61
|
-
|
|
62
|
-
|
|
63
|
-
"
|
|
64
|
-
"
|
|
65
|
-
|
|
66
|
-
|
|
67
|
-
"
|
|
68
|
-
|
|
69
|
-
|
|
70
|
-
"
|
|
71
|
-
"
|
|
72
|
-
"citation": {"type": "string"}
|
|
46
|
+
"esearchresult": {
|
|
47
|
+
"type": "object",
|
|
48
|
+
"properties": {
|
|
49
|
+
"count": {
|
|
50
|
+
"type": "string",
|
|
51
|
+
"description": "Number of datasets found"
|
|
52
|
+
},
|
|
53
|
+
"idlist": {
|
|
54
|
+
"type": "array",
|
|
55
|
+
"items": {
|
|
56
|
+
"type": "string"
|
|
57
|
+
},
|
|
58
|
+
"description": "List of GEO dataset IDs"
|
|
59
|
+
},
|
|
60
|
+
"querytranslation": {
|
|
61
|
+
"type": "string",
|
|
62
|
+
"description": "Translated search query"
|
|
73
63
|
}
|
|
74
64
|
}
|
|
75
|
-
}
|
|
76
|
-
|
|
77
|
-
|
|
65
|
+
}
|
|
66
|
+
}
|
|
67
|
+
},
|
|
68
|
+
"test_examples": [
|
|
69
|
+
{
|
|
70
|
+
"query": "cancer",
|
|
71
|
+
"organism": "Homo sapiens",
|
|
72
|
+
"limit": 10
|
|
73
|
+
},
|
|
74
|
+
{
|
|
75
|
+
"query": "diabetes",
|
|
76
|
+
"study_type": "Expression profiling by array",
|
|
77
|
+
"limit": 5
|
|
78
|
+
}
|
|
79
|
+
],
|
|
80
|
+
"label": [
|
|
81
|
+
"GEO",
|
|
82
|
+
"Dataset",
|
|
83
|
+
"Search"
|
|
84
|
+
],
|
|
85
|
+
"metadata": {
|
|
86
|
+
"tags": ["expression", "microarray", "search"],
|
|
87
|
+
"difficulty_level": "easy",
|
|
88
|
+
"estimated_execution_time": "< 3 seconds"
|
|
89
|
+
}
|
|
90
|
+
},
|
|
91
|
+
{
|
|
92
|
+
"type": "GEOGetDatasetInfo",
|
|
93
|
+
"name": "geo_get_dataset_info",
|
|
94
|
+
"description": "Get detailed information about a specific GEO dataset including title, summary, and metadata.",
|
|
95
|
+
"parameter": {
|
|
96
|
+
"type": "object",
|
|
97
|
+
"properties": {
|
|
98
|
+
"dataset_id": {
|
|
99
|
+
"type": "string",
|
|
100
|
+
"description": "GEO dataset ID (e.g., 'GDS1234', 'GSE12345')"
|
|
101
|
+
}
|
|
102
|
+
},
|
|
103
|
+
"required": ["dataset_id"]
|
|
104
|
+
},
|
|
105
|
+
"fields": {
|
|
106
|
+
"endpoint": "/esummary.fcgi",
|
|
107
|
+
"return_format": "JSON"
|
|
108
|
+
},
|
|
109
|
+
"return_schema": {
|
|
110
|
+
"type": "object",
|
|
111
|
+
"description": "GEO dataset information",
|
|
112
|
+
"properties": {
|
|
113
|
+
"result": {
|
|
114
|
+
"type": "object",
|
|
115
|
+
"description": "Dataset information from GEO",
|
|
116
|
+
"properties": {
|
|
117
|
+
"uid": {
|
|
118
|
+
"type": "string",
|
|
119
|
+
"description": "Dataset UID"
|
|
120
|
+
},
|
|
121
|
+
"title": {
|
|
122
|
+
"type": "string",
|
|
123
|
+
"description": "Dataset title"
|
|
124
|
+
},
|
|
125
|
+
"summary": {
|
|
126
|
+
"type": "string",
|
|
127
|
+
"description": "Dataset summary"
|
|
128
|
+
},
|
|
129
|
+
"organism": {
|
|
130
|
+
"type": "string",
|
|
131
|
+
"description": "Organism"
|
|
132
|
+
},
|
|
133
|
+
"platform": {
|
|
134
|
+
"type": "string",
|
|
135
|
+
"description": "Platform used"
|
|
136
|
+
},
|
|
137
|
+
"samples": {
|
|
138
|
+
"type": "string",
|
|
139
|
+
"description": "Number of samples"
|
|
140
|
+
}
|
|
141
|
+
}
|
|
142
|
+
}
|
|
143
|
+
}
|
|
144
|
+
},
|
|
145
|
+
"test_examples": [
|
|
146
|
+
{
|
|
147
|
+
"dataset_id": "GDS1234"
|
|
148
|
+
},
|
|
149
|
+
{
|
|
150
|
+
"dataset_id": "GSE12345"
|
|
151
|
+
}
|
|
152
|
+
],
|
|
153
|
+
"label": [
|
|
154
|
+
"GEO",
|
|
155
|
+
"Dataset",
|
|
156
|
+
"Information"
|
|
157
|
+
],
|
|
158
|
+
"metadata": {
|
|
159
|
+
"tags": ["dataset", "metadata", "expression"],
|
|
160
|
+
"difficulty_level": "easy",
|
|
161
|
+
"estimated_execution_time": "< 3 seconds"
|
|
162
|
+
}
|
|
163
|
+
},
|
|
164
|
+
{
|
|
165
|
+
"type": "GEOGetSampleInfo",
|
|
166
|
+
"name": "geo_get_sample_info",
|
|
167
|
+
"description": "Get sample information for a GEO dataset including sample characteristics and experimental conditions.",
|
|
168
|
+
"parameter": {
|
|
169
|
+
"type": "object",
|
|
170
|
+
"properties": {
|
|
171
|
+
"dataset_id": {
|
|
172
|
+
"type": "string",
|
|
173
|
+
"description": "GEO dataset ID (e.g., 'GDS1234', 'GSE12345')"
|
|
174
|
+
}
|
|
175
|
+
},
|
|
176
|
+
"required": ["dataset_id"]
|
|
177
|
+
},
|
|
178
|
+
"fields": {
|
|
179
|
+
"endpoint": "/esummary.fcgi",
|
|
180
|
+
"return_format": "JSON"
|
|
181
|
+
},
|
|
182
|
+
"return_schema": {
|
|
183
|
+
"type": "object",
|
|
184
|
+
"description": "GEO sample information",
|
|
185
|
+
"properties": {
|
|
186
|
+
"result": {
|
|
187
|
+
"type": "object",
|
|
188
|
+
"description": "Sample information from GEO",
|
|
189
|
+
"properties": {
|
|
190
|
+
"uid": {
|
|
191
|
+
"type": "string",
|
|
192
|
+
"description": "Dataset UID"
|
|
193
|
+
},
|
|
194
|
+
"samples": {
|
|
195
|
+
"type": "array",
|
|
196
|
+
"description": "Array of sample information",
|
|
197
|
+
"items": {
|
|
198
|
+
"type": "object",
|
|
199
|
+
"properties": {
|
|
200
|
+
"sample_id": {
|
|
201
|
+
"type": "string",
|
|
202
|
+
"description": "Sample identifier"
|
|
203
|
+
},
|
|
204
|
+
"characteristics": {
|
|
205
|
+
"type": "string",
|
|
206
|
+
"description": "Sample characteristics"
|
|
207
|
+
},
|
|
208
|
+
"treatment": {
|
|
209
|
+
"type": "string",
|
|
210
|
+
"description": "Treatment conditions"
|
|
211
|
+
}
|
|
212
|
+
}
|
|
213
|
+
}
|
|
214
|
+
}
|
|
215
|
+
}
|
|
216
|
+
}
|
|
78
217
|
}
|
|
79
218
|
},
|
|
80
|
-
"
|
|
81
|
-
|
|
82
|
-
|
|
83
|
-
|
|
219
|
+
"test_examples": [
|
|
220
|
+
{
|
|
221
|
+
"dataset_id": "GDS1234"
|
|
222
|
+
},
|
|
223
|
+
{
|
|
224
|
+
"dataset_id": "GSE12345"
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}
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],
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"label": [
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"GEO",
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"Sample",
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"Information"
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],
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"metadata": {
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"tags": ["sample", "characteristics", "expression"],
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"difficulty_level": "easy",
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"estimated_execution_time": "< 3 seconds"
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@@ -0,0 +1,109 @@
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[
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{
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"type": "gnomADGetGeneConstraints",
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4
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+
"name": "gnomad_get_gene_constraints",
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5
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"description": "Get gene constraint metrics from gnomAD. Returns pLI, LOEUF, and other constraint scores for genes.",
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6
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"parameter": {
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7
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"type": "object",
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"properties": {
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9
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"gene_symbol": {
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10
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+
"type": "string",
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11
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"description": "Gene symbol (e.g., 'BRCA1', 'TP53')"
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}
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},
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"required": ["gene_symbol"]
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},
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"fields": {
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"endpoint": "https://gnomad.broadinstitute.org/api",
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18
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"return_format": "JSON",
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19
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"query_schema": "query GeneConstraints($geneSymbol: String!) { gene(gene_symbol: $geneSymbol, reference_genome: GRCh38) { symbol gene_id exac_constraint { exp_lof obs_lof pLI exp_mis obs_mis exp_syn obs_syn } gnomad_constraint { exp_lof obs_lof oe_lof pLI exp_mis obs_mis oe_mis exp_syn obs_syn oe_syn } } }"
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},
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"return_schema": {
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"type": "object",
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"description": "gnomAD gene constraint data",
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"properties": {
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"status": {
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"type": "string",
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"description": "Status of the request"
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},
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"data": {
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"type": "object",
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"description": "GraphQL response data",
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"properties": {
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"data": {
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"type": "object",
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"properties": {
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36
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"gene": {
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"type": "object",
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"properties": {
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"symbol": {
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40
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"type": "string",
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"description": "Gene symbol"
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},
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"gene_id": {
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"type": "string",
|
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+
"description": "Ensembl gene ID"
|
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+
},
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47
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+
"exac_constraint": {
|
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48
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"type": "object",
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"description": "ExAC constraint metrics",
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"properties": {
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51
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"exp_lof": {
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"type": "number",
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53
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"description": "Expected number of loss-of-function variants"
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},
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"obs_lof": {
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56
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"type": "number",
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"description": "Observed number of loss-of-function variants"
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},
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+
"pLI": {
|
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60
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+
"type": "number",
|
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61
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+
"description": "Probability of being loss-of-function intolerant"
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+
}
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}
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},
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"gnomad_constraint": {
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66
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"type": "object",
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67
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"description": "gnomAD constraint metrics",
|
|
68
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+
"properties": {
|
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"oe_lof": {
|
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70
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+
"type": "number",
|
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71
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+
"description": "Observed/Expected ratio for loss-of-function variants"
|
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+
},
|
|
73
|
+
"pLI": {
|
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74
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+
"type": "number",
|
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75
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+
"description": "Probability of being loss-of-function intolerant"
|
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+
}
|
|
77
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+
}
|
|
78
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+
}
|
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79
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+
}
|
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}
|
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}
|
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+
}
|
|
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+
}
|
|
84
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+
},
|
|
85
|
+
"gene_symbol": {
|
|
86
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+
"type": "string",
|
|
87
|
+
"description": "Input gene symbol"
|
|
88
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+
}
|
|
89
|
+
}
|
|
90
|
+
},
|
|
91
|
+
"test_examples": [
|
|
92
|
+
{
|
|
93
|
+
"description": "Get constraint metrics for BRCA1 gene",
|
|
94
|
+
"input": {
|
|
95
|
+
"gene_symbol": "BRCA1"
|
|
96
|
+
},
|
|
97
|
+
"expected_output": {
|
|
98
|
+
"status": "success",
|
|
99
|
+
"data": "Gene constraint data with pLI and LOEUF scores"
|
|
100
|
+
}
|
|
101
|
+
}
|
|
102
|
+
],
|
|
103
|
+
"metadata": {
|
|
104
|
+
"tags": ["constraint", "pLI", "LOEUF", "gnomAD"],
|
|
105
|
+
"difficulty_level": "intermediate",
|
|
106
|
+
"estimated_execution_time": "< 3 seconds"
|
|
107
|
+
}
|
|
108
|
+
}
|
|
109
|
+
]
|