geney 1.2.20__py2.py3-none-any.whl → 1.2.22__py2.py3-none-any.whl

geney/oncosplice.py

@@ -1047,7 +1047,7 @@ class PredictSpliceAI:
 
             # self.missplicing = run_spliceai_transcript(self.modification, transcript_data=gene_data, sai_mrg_context=sai_mrg_context, min_coverage=min_coverage, sai_threshold=0.1)
             # print(f"RUNNING: {mutation.mut_id}")
-            ref_transcript, var_transcript = Gene(mutation.mut_id.split(':')[0], organism=organism).transcript(gene_data.transcript_id), Gene(mutation.mut_id.split(':')[0], mutation.mut_id, organism='mm39').transcript(gene_data.transcript_id)
+            ref_transcript, var_transcript = Gene(mutation.mut_id.split(':')[0], organism=organism).transcript(gene_data.transcript_id), Gene(mutation.mut_id.split(':')[0], mutation.mut_id, organism=organism).transcript(gene_data.transcript_id)
             # print(f"Second check : {ref_transcript.pre_mrna == var_transcript.pre_mrna}")
             self.missplicing = find_transcript_missplicing(self.modification, ref_transcript, var_transcript, context=sai_mrg_context+min_coverage, threshold=threshold,
                                 engine=engine)

{geney-1.2.20.dist-info → geney-1.2.22.dist-info}/METADATA

@@ -1,6 +1,6 @@
 Metadata-Version: 2.1
 Name: geney
-Version: 1.2.20
+Version: 1.2.22
 Summary: A Python package for gene expression modeling.
 Home-page: https://github.com/nicolaslynn/geney
 Author: Nicolas Lynn

geney-1.2.22.dist-info/RECORD

@@ -0,0 +1,19 @@
+geney/Fasta_segment.py,sha256=0zCdzPUbDeM9Rz642woH5Q94pwI46O0fE3H8w0XWebc,11255
+geney/__init__.py,sha256=knezxgbV2c2gcO2ek2-xxEC15HL4aO1WuoMiYOOvKf8,428
+geney/config_setup.py,sha256=VA6mhVGMRadwlpEx4m1wrssmDM8qpfKT21MAijIwjyQ,428
+geney/data_setup.py,sha256=LTiJMYPgv9KnIgUNw-D57Fu4nxL4OojXMpmdhE8QSYU,12228
+geney/gtex_utils.py,sha256=asL2lHyU5KsbWpV096vkf1Ka7hSo_RRfZqw7p5nERmE,1919
+geney/immune_utils.py,sha256=ZRni5ttrhpYBnmNr0d0ZatIbNPYs4nmQuoUO00SpsS4,5271
+geney/oncosplice.py,sha256=AZm8Vj7z65DokPmeflwoqs2BM11neV9hQLA_Ao4ysnM,78242
+geney/power_utils.py,sha256=MehZFUdkJ2EFUot709yPEDxSkXmH5XevMebX2HD768A,7330
+geney/survival_utils.py,sha256=2CAkC2LsspicHIdrqsiPnjgvpr5KHDUfLFFqnRbPJqs,5762
+geney/tcga_utils.py,sha256=vXSMf1OxoF_AdE_rMguy_BoYaart_E1t4FFMx2DS1Ak,15585
+geney/utils.py,sha256=xJi7fk3g7DkR2rKOb8WePLQNM1ib83rcHecwRdwd5lA,2036
+geney/translation_initiation/__init__.py,sha256=47DEQpj8HBSa-_TImW-5JCeuQeRkm5NMpJWZG3hSuFU,0
+geney/translation_initiation/tis_utils.py,sha256=iXrWVijyPe-f8I9rEVGdxNnXBrOGPoKFjmvaOEnQYNE,4446
+geney/translation_initiation/resources/kozak_pssm.json,sha256=pcd0Olziutq-6H3mFWDCD9cujQ_AlZO-iiOvBl82hqE,1165
+geney/translation_initiation/resources/tis_regressor_model.joblib,sha256=IXb4DUDhJ5rBDKcqMk9zE3ECTZZcdj7Jixz3KpoZ7OA,2592025
+geney-1.2.22.dist-info/METADATA,sha256=eTTiyuGPZ5lD7jV8YZXSocPyewD3OPwvgeaqiXxuVfo,1163
+geney-1.2.22.dist-info/WHEEL,sha256=AHX6tWk3qWuce7vKLrj7lnulVHEdWoltgauo8bgCXgU,109
+geney-1.2.22.dist-info/top_level.txt,sha256=O-FuNUMb5fn9dhZ-dYCgF0aZtfi1EslMstnzhc5IIVo,6
+geney-1.2.22.dist-info/RECORD,,

geney/Gene.py

@@ -1,258 +0,0 @@
-from copy import copy
-from Bio.Seq import Seq
-from geney.mutations.variant_utils import generate_mut_variant, Mutation, find_new_tts
-from geney.utils import find_files_by_gene_name, reverse_complement, unload_pickle
-from geney.Fasta_segment import Fasta_segment
-from geney import config_setup
-from geney.translation_initiation.tis_utils import TISFInder
-
-
-class Gene:
-    def __init__(self, gene_name, variation):
-        self.gene_name = gene_name
-        self.gene_id = ''
-        self.rev = None
-        self.chrm = ''
-        self.gene_start = 0
-        self.gene_end = 0
-        self.transcripts = {}
-        self.load_from_file(find_files_by_gene_name(gene_name))
-        self.variation = variation
-
-    def __repr__(self):
-        return f'Gene(gene_name={self.gene_name})'
-
-    def __len__(self):
-        return len(self.transcripts)
-
-    def __str__(self):
-        return '{gname}, {ntranscripts} transcripts'.format(gname=self.gene_name, ntranscripts=self.__len__())
-
-    def __copy__(self):
-        cls = self.__class__
-        result = cls.__new__(cls)
-        result.__dict__.update(self.__dict__)
-        return result
-
-    def __getitem__(self, index):
-        return Transcript(list(self.transcripts.values())[index])
-
-    def load_from_file(self, file_name):
-        if not file_name.exists():
-            raise FileNotFoundError(f"File '{file_name}' not found.")
-
-        self.load_from_dict(dict_data=unload_pickle(file_name))
-        return self
-
-    def load_from_dict(self, dict_data=None):
-        for k, v in dict_data.items():
-            setattr(self, k, v)
-        return self
-
-    # def generate_transcript(self, tid=None):
-    #     if tid == None:
-    #         tid = [k for k, v in self.transcripts.items() if v['primary_transcript']][0]
-    #     return Transcript(self.transcripts[tid])
-
-    def transcript(self, tid):
-        if tid not in self.transcripts:
-            raise AttributeError(f"Transcript '{tid}' not found in gene '{self.gene_name}'.")
-        return Transcript(self.transcripts[tid]) #self.generate_transcript(tid)
-
-
-class Transcript:
-    def __init__(self, d=None):
-        self.transcript_id = None
-        self.transcript_start = None                            # transcription
-        self.transcript_end = None                              # transcription
-        self.transcript_biotype = None                          # metadata
-        self.acceptors, self.donors = [], []                    # splicing
-        self.TIS, self.TTS = None, None                         # translation
-        self.transcript_seq, self.transcript_indices = '', []   # sequence data
-        self.rev = None                                         # sequence data
-        self.chrm = ''                                          # sequence data
-        self.pre_mrna = ''                                      # sequence data
-        self.orf = ''                                           # sequence data
-        self.protein = ''                                       # sequence data
-        self.log = ''                                           # sequence data
-        self.primary_transcript=None                            # sequence data
-        self.cons_available=False                               # metadata
-        self.cons_seq = ''
-        self.cons_vector = ''
-        if d:
-            self.load_from_dict(d)
-
-        if self.cons_available:
-            if '*' in self.cons_seq and len(self.cons_seq) == len(self.cons_vector):
-                self.cons_seq = self.cons_seq.replace('*', '')
-                self.cons_vector = self.cons_vector[:-1]
-
-            elif '*' in self.cons_seq and len(self.cons_seq) == len(self.cons_vector) + 1:
-                self.cons_seq = self.cons_seq.replace('*', '')
-
-            else:
-                self.cons_available = False
-
-
-    def __repr__(self):
-        return 'Transcript(transcript_id={tid})'.format(tid=self.transcript_id)
-
-    def __len__(self):
-        return len(self.transcript_seq)
-
-    def __str__(self):
-        return 'Transcript {tid}, Transcript Type: ' \
-               '{protein_coding}'.format(
-                tid=self.transcript_id, protein_coding=self.transcript_biotype)
-
-    def __eq__(self, other):
-        return self.transcript_seq == other.transcript_seq
-
-    def __contains__(self, subvalue):
-        if isinstance(subvalue, str):
-            return subvalue in self.transcript_seq
-        elif isinstance(subvalue, int):
-            return subvalue in self.transcript_indices
-        else:
-            print(
-                "Pass an integer to check against the span of the gene's coordinates or a string to check against the "
-                "pre-mRNA sequence.")
-            return False
-
-    def __copy__(self, other):
-        return copy(self)
-
-    @property
-    def constructor(self):
-        core_attributes = ['transcript_id', 'transcript_start', 'transcript_end', 'transcript_biotype', 'acceptors', 'donors', 'TIS', 'TTS', 'rev', 'chrm']
-        return {k: v for k, v in self.__dict__.items() if k in core_attributes}
-
-    def load_from_dict(self, data):
-        for k, v in data.items():
-            setattr(self, k, v)
-        self.__arrange_boundaries()
-        self.generate_mature_mrna(inplace=True)
-        return self
-
-    @property
-    def exons(self):
-        return list(zip(self.acceptors, self.donors))
-
-    @property
-    def introns(self):
-        return list(zip([v for v in self.donors if v != self.transcript_end], [v for v in self.acceptors if v != self.transcript_start]))
-
-
-    def set_exons(self, boundaries):
-        self.acceptors, self.donors = boundaries['acceptors'], boundaries['donors']
-        self.__arrange_boundaries()
-        return self
-
-    @property
-    def introns(self):
-        return list(zip([v for v in self.donors if v != self.transcript_end], [v for v in self.acceptors if v != self.transcript_start]))
-
-    def __exon_coverage_check(self):
-        if sum([abs(a-b) + 1 for a, b in self.exons]) == len(self):
-            return True
-        else:
-            return False
-
-    @property
-    def exons_pos(self):
-        temp = self.exons
-        if self.rev:
-            temp = [(b, a) for a, b in temp[::-1]]
-        return temp
-
-    @property
-    def mrna_indices(self):
-        temp = [lst for lsts in [list(range(a, b+1)) for a, b in self.exons_pos] for lst in lsts]
-        return sorted(temp, reverse=self.rev)
-
-    @property
-    def exonic_indices(self):
-        return [lst for lsts in [list(range(a, b+1)) for a, b in self.exons_pos] for lst in lsts]
-
-    def __arrange_boundaries(self):
-        self.acceptors.append(self.transcript_start)
-        self.donors.append(self.transcript_end)
-        self.acceptors = list(set(self.acceptors))
-        self.donors = list(set(self.donors))
-        self.acceptors.sort(reverse=self.rev)
-        self.donors.sort(reverse=self.rev)
-        return self
-
-    def positive_strand(self):
-        if self.rev:
-            return reverse_complement(self.transcript_seq)
-        else:
-            return self.transcript_seq
-
-    def __pos2sense(self, mrna, indices):
-        if self.rev:
-            mrna = reverse_complement(mrna)
-            indices = indices[::-1]
-        return mrna, indices
-
-    def pull_pre_mrna_pos(self):
-        fasta_obj = Fasta_segment()
-        if self.rev:
-            return fasta_obj.read_segment_endpoints(config_setup['CHROM_SOURCE'] / f'chr{self.chrm}.fasta', self.transcript_end,
-                                                                   self.transcript_start)
-        else:
-            return fasta_obj.read_segment_endpoints(config_setup['CHROM_SOURCE'] / f'chr{self.chrm}.fasta', self.transcript_start,
-                                                                   self.transcript_end)
-
-    def generate_pre_mrna_pos(self, mutations=[]):
-        seq, indices = self.pull_pre_mrna_pos()
-        for mutation in mutations:
-            mutation = Mutation(mutation)
-            seq, indices, _, _ = generate_mut_variant(seq, indices, mut=mutation)
-
-        self.pre_mrna, _ = self.__pos2sense(seq, indices)
-        return seq, indices
-
-    def generate_pre_mrna(self, mutations=[], inplace=True):
-        pre_mrna, pre_indices = self.__pos2sense(*self.generate_pre_mrna_pos(mutations))
-        self.pre_mrna = pre_mrna
-        if inplace:
-            return self
-        return pre_mrna
-
-    def generate_mature_mrna_pos(self, mutations=[]):
-        mature_mrna, mature_indices = '', []
-        pre_seq, pre_indices = self.generate_pre_mrna_pos(mutations)
-        for i, j in self.exons_pos:
-            rel_start, rel_end = pre_indices.index(i), pre_indices.index(j)
-            mature_mrna += pre_seq[rel_start:rel_end + 1]
-            mature_indices.extend(pre_indices[rel_start:rel_end + 1])
-        return mature_mrna, mature_indices
-
-    def generate_mature_mrna(self, mutations=[], inplace=True):
-        if inplace:
-            self.transcript_seq, self.transcript_indices = self.__pos2sense(*self.generate_mature_mrna_pos(mutations))
-            return self
-        return self.__pos2sense(*self.generate_mature_mrna_pos(mutations))
-
-    def generate_protein(self, inplace=True):
-        rel_start = self.transcript_indices.index(self.TIS)
-        rel_end = self.transcript_indices.index(self.TTS)
-        orf = self.transcript_seq[rel_start:rel_end + 1 + 3]
-        protein = str(Seq(orf).translate()).replace('*', '')
-        if inplace:
-            self.orf = orf
-            self.protein = protein
-            if self.protein != self.cons_seq:
-                self.cons_available = False
-            return self
-        return protein
-
-    def generate_translational_boundaries(self):
-        if self.TIS not in self.transcript_indices or self.transcript_seq[self.transcript_indices.index(self.TIS):self.transcript_indices.index(self.TIS)+3] != 'ATG':
-            new_tis = TISFInder(self.transcript_seq, self.transcript_indices)
-            self.log += f' TIS for transcript reacquired: {self.TIS} --> {new_tis}.'
-            self.TIS = new_tis
-        self.TTS = find_new_tts(self.transcript_seq, self.transcript_indices, self.TIS)
-        return self
-

geney/analyzers/benchmark_clinvar.py

@@ -1,158 +0,0 @@
-import pandas as pd
-from sklearn.metrics import roc_curve, precision_recall_curve
-import matplotlib.pyplot as plt
-from datetime import datetime
-from pathlib import Path
-import subprocess
-
-from geney import config_setup
-from geney.utils import download_and_gunzip
-from geney.oncosplice import oncosplice_reduced
-
-def download_and_parse_clinvar():
-    url = 'https://ftp.ncbi.nlm.nih.gov/pub/clinvar/vcf_GRCh38/clinvar.vcf.gz'
-    local_file = download_and_gunzip(url, target_path)
-    return local_file
-
-
-def aggregate_clinvar_results(benchmark_path, aggregate_mode=False, benchmark_feature=None, local_clinvar_df='/tamir2/nicolaslynn/data/ClinVar/clinvar_compact.csv'):
-    data = pd.concat([pd.read_csv(file) for file in Path(benchmark_path).glob('*.csv')])
-    if not aggregate_mode:
-        data = data[(data.cons_available) & (data.primary_transcript)]
-
-    data = oncosplice_reduced(data)
-    data = data.loc[:, ~data.columns.duplicated()]
-    data = pd.merge(data, pd.read_csv(local_clinvar_df), on='mut_id')
-    data['clinsig_val'] = data.apply(lambda row: {'Benign': 0, 'Pathogenic': 1}[row.clinsig], axis=1)
-    for c in data.columns:
-        try:
-            if data[c].min() < 0:
-                data[f'{c}_abs'] = abs(data[c])
-        except TypeError:
-            pass
-
-    print(data.corr(numeric_only=True))
-    print(data.corrwith(data['clinsig_val'], method='spearman'))
-    print(data.corrwith(data['clinsig_val'], method='pearson'))
-    return data
-
-
-def plot_performance(true_values, predictions):
-    clinsig_map = {'Benign': 0, 'Pathogenic': 1}
-    true_values = [clinsig_map[t] for t in true_values]
-    predictions = scale_predictions(predictions)
-
-    fpr, tpr, thresholds_roc = roc_curve(true_values, predictions)
-
-    # Calculate Precision-Recall curve
-    precision, recall, thresholds_pr = precision_recall_curve(true_values, predictions)
-
-    # Plotting ROC curve
-    plt.figure(figsize=(20, 5))
-
-    plt.subplot(1, 4, 1)
-    plt.plot(fpr, tpr)
-    plt.title('ROC Curve')
-    plt.xlabel('False Positive Rate')
-    plt.ylabel('True Positive Rate')
-
-    # Plotting Precision-Recall curve
-    plt.subplot(1, 4, 2)
-    plt.plot(recall, precision)
-    plt.title('Precision-Recall Curve')
-    plt.xlabel('Recall')
-    plt.ylabel('Precision')
-
-    # Plotting Precision vs. Thresholds
-    plt.subplot(1, 4, 3)
-    plt.plot(thresholds_pr, precision[:-1])  # Precision and thresholds have off-by-one lengths
-    plt.title('Precision vs. Threshold')
-    plt.xlabel('Threshold')
-    plt.ylabel('Precision')
-
-    # Plotting Sample Percentage Captured vs. Thresholds
-    plt.subplot(1, 4, 4)
-    # Assuming 'tpr' or another appropriate metric represents the cumulative percentage
-    plt.plot(thresholds_roc, tpr)  # Update 'tpr' with the correct metric if necessary
-    plt.title('Cumulative Percentage vs. Threshold')
-    plt.xlabel('Threshold')
-    plt.ylabel('Cumulative Percentage of Population')
-
-    plt.tight_layout()
-    plt.show()
-
-
-
-class ClinVarBenchmark:
-    def __init__(self, df):
-        assert 'clinsig' in df.columns, 'No clinsig column found in dataframe.'
-        self.df = df
-
-
-    def scale_predictions(self, p):
-        max_val = max(p)
-        min_val = min(p)
-        return (p - min_val) / (max_val - min_val)
-
-    def plot_performance(self, true_values, predictions):
-        clinsig_map = {'Benign': 0, 'Pathogenic': 1}
-        predictions = [clinsig_map[t] for t in true_values]
-        predictions = self.scale_predictions(predictions)
-
-        fpr, tpr, thresholds_roc = roc_curve(true_values, predictions)
-
-        # Calculate Precision-Recall curve
-        precision, recall, thresholds_pr = precision_recall_curve(true_values, predictions)
-
-        # Plotting ROC curve
-        plt.figure(figsize=(20, 5))
-
-        plt.subplot(1, 4, 1)
-        plt.plot(fpr, tpr)
-        plt.title('ROC Curve')
-        plt.xlabel('False Positive Rate')
-        plt.ylabel('True Positive Rate')
-
-        # Plotting Precision-Recall curve
-        plt.subplot(1, 4, 2)
-        plt.plot(recall, precision)
-        plt.title('Precision-Recall Curve')
-        plt.xlabel('Recall')
-        plt.ylabel('Precision')
-
-        # Plotting Precision vs. Thresholds
-        plt.subplot(1, 4, 3)
-        plt.plot(thresholds_pr, precision[:-1])  # Precision and thresholds have off-by-one lengths
-        plt.title('Precision vs. Threshold')
-        plt.xlabel('Threshold')
-        plt.ylabel('Precision')
-
-        # Plotting Sample Percentage Captured vs. Thresholds
-        plt.subplot(1, 4, 4)
-        # Assuming 'tpr' or another appropriate metric represents the cumulative percentage
-        plt.plot(thresholds_roc, tpr)  # Update 'tpr' with the correct metric if necessary
-        plt.title('Cumulative Percentage vs. Threshold')
-        plt.xlabel('Threshold')
-        plt.ylabel('Cumulative Percentage of Population')
-
-        plt.tight_layout()
-        plt.show()
-        return None
-
-    def report(self, feature):
-        pass
-
-    def find_ppv_threshold(self, feature, ppv_threshold=0.95):
-        pass
-
-
-
-if __name__ ==  '__main__':
-    now = datetime.now()
-    benchmark_path = config_setup['ONCOSPLICE'] / f'clinvar_benchmark_{now.strftime("%m_%d_%Y")}'
-    print(f"Saving benchmark results to {benchmark_path}")
-    benchmark_path.mkdir(parents=True, exist_ok=True)
-    subprocess.run(['python', '-m', 'geney.pipelines.dask_utils', '-i',
-                    '/tamir2/nicolaslynn/data/ClinVar/clinvar_oncosplice_input.txt', '-r', str(benchmark_path),
-                    '-n', '10', '-m', '5GB'])
-

geney/analyzers/characterize_epistasis.py

@@ -1,15 +0,0 @@
-from geney.oncosplice import *
-
-class PairwiseEpistasis:
-    def __init__(self, epistasis):
-        # need some check here making sure format of mtuations isi good
-        self.epistasis = epistasis
-        self.mut_id1, self.mut_id2 = epistasis.split('|')
-
-    def compare_functional_changes(self):
-        self.results_mut1 = oncosplice(self.mut_id1, sai_threshold=0.5)
-        self.results_mut2 = oncosplice(self.mut_id2, sai_threshold=0.5)
-        self.results_epi = oncosplice(self.epistasis, sai_threshold=0.5)
-
-        splicing1, splicing2, splicing_epi = 0, 0, 0
-        oncosplice_score1, oncosplice_score2, oncosplice_score_epi = 0, 0, 0

geney/analyzers/compare_sets.py

@@ -1,91 +0,0 @@
-import pandas as pd
-import numpy as np
-from sklearn.metrics import precision_score, recall_score, accuracy_score
-from sklearn.metrics import roc_auc_score, roc_curve
-import matplotlib.pyplot as plt
-
-def plot_auc_curve(y_true, y_pred_proba):
-    """
-    Plots the AUC curve.
-
-    Args:
-        y_true (array-like): True labels (0 or 1).
-        y_pred_proba (array-like): Predicted probabilities for positive class.
-
-    Returns:
-        None
-    """
-    fpr, tpr, _ = roc_curve(y_true, y_pred_proba)
-    auc_value = roc_auc_score(y_true, y_pred_proba)
-
-    plt.figure(figsize=(8, 6))
-    plt.plot(fpr, tpr, label=f"AUC = {auc_value:.2f}")
-    plt.plot([0, 1], [0, 1], 'k--')
-    plt.xlabel("False Positive Rate")
-    plt.ylabel("True Positive Rate")
-    plt.title("Receiver Operating Characteristic (ROC) Curve")
-    plt.legend()
-    plt.show()
-    return auc_value
-
-
-def optimal_ppv(dataframe, feature_name, plot=False):
-    """
-    Calculates the optimal positive predictive value (PPV) for a given feature.
-
-    Args:
-        dataframe (pd.DataFrame): Input dataframe.
-        feature_name (str): Name of the feature column.
-
-    Returns:
-        float: Optimal PPV.
-    """
-    # Assuming 'target' is the binary target column (0 or 1)
-    threshold_values = pd.qcut(dataframe[feature_name], 100, duplicates='drop')
-    ppv_values = []
-
-    for threshold in threshold_values:
-        predictions = (dataframe[feature_name] >= threshold).astype(int)
-        ppv = precision_score(dataframe['target'], predictions)
-        ppv_values.append(ppv)
-
-    optimal_threshold = threshold_values[np.argmax(ppv_values)]
-    optimal_ppv = max(ppv_values)
-    if plot:
-        plt.figure(figsize=(8, 6))
-        plt.scatter(threshold_values, ppv_values)
-        plt.xlabel("Threshold")
-        plt.ylabel("Positive Predictive Value (PPV)")
-        plt.title("Optimal Positive Predictive Value (PPV)")
-        plt.show()
-
-    return optimal_ppv, optimal_threshold
-
-
-def measure_prediction_quality(prediction_vector, quality_vector):
-    """
-    Measure the quality of the predictions using the quality_vector as the characteristic to check.
-    """
-    pass
-
-
-
-def create_ppv_vector(prediction_vector, true_value_vector):
-    """
-    Create a vector of positive predictive values (PPV) for the prediction_vector using the true_value_vector as the true values.
-    """
-    df = pd.DataFrame({'prediction': prediction_vector, 'true_value': true_value_vector})
-    df.sort_values('prediction', ascending=True, inplace=True)
-    df['bin'] = pd.qcut(df['prediction'], 100, labels=False, duplicates=True, retbins=True)
-    for bin in df.bin.unique():
-        temp_df = df[df.bin >= bin].
-
-
-def group_retention(predictions, predictor):
-    # first i need to get the ratio of values that are retained at particular values
-    predictions.sort_values(predictor, inplace=True)
-    _, thresholds = pd.qcut(predictions[predictor], 100, duplicates='drop')
-    tracker = []
-    for th in thresholds:
-
-

geney/analyzers/group_comparison.py

@@ -1,81 +0,0 @@
-import pandas as pd
-import numpy as np
-from sklearn.metrics import precision_score, recall_score, accuracy_score
-from sklearn.metrics import roc_auc_score, roc_curve
-import matplotlib.pyplot as plt
-
-def plot_auc_curve(y_true, y_pred_proba):
-    """
-    Plots the AUC curve.
-
-    Args:
-        y_true (array-like): True labels (0 or 1).
-        y_pred_proba (array-like): Predicted probabilities for positive class.
-
-    Returns:
-        None
-    """
-    fpr, tpr, _ = roc_curve(y_true, y_pred_proba)
-    auc_value = roc_auc_score(y_true, y_pred_proba)
-
-    plt.figure(figsize=(8, 6))
-    plt.plot(fpr, tpr, label=f"AUC = {auc_value:.2f}")
-    plt.plot([0, 1], [0, 1], 'k--')
-    plt.xlabel("False Positive Rate")
-    plt.ylabel("True Positive Rate")
-    plt.title("Receiver Operating Characteristic (ROC) Curve")
-    plt.legend()
-    plt.show()
-    return auc_value
-
-
-def optimal_ppv(dataframe, feature_name, plot=False):
-    """
-    Calculates the optimal positive predictive value (PPV) for a given feature.
-
-    Args:
-        dataframe (pd.DataFrame): Input dataframe.
-        feature_name (str): Name of the feature column.
-
-    Returns:
-        float: Optimal PPV.
-    """
-    # Assuming 'target' is the binary target column (0 or 1)
-    threshold_values = pd.qcut(dataframe[feature_name], 100, duplicates='drop')
-    ppv_values = []
-
-    for threshold in threshold_values:
-        predictions = (dataframe[feature_name] >= threshold).astype(int)
-        ppv = precision_score(dataframe['target'], predictions)
-        ppv_values.append(ppv)
-
-    optimal_threshold = threshold_values[np.argmax(ppv_values)]
-    optimal_ppv = max(ppv_values)
-    if plot:
-        plt.figure(figsize=(8, 6))
-        plt.scatter(threshold_values, ppv_values)
-        plt.xlabel("Threshold")
-        plt.ylabel("Positive Predictive Value (PPV)")
-        plt.title("Optimal Positive Predictive Value (PPV)")
-        plt.show()
-
-    return optimal_ppv, optimal_threshold
-
-
-def measure_prediction_quality(prediction_vector, quality_vector):
-    """
-    Measure the quality of the predictions using the quality_vector as the characteristic to check.
-    """
-    pass
-
-
-
-def create_ppv_vector(prediction_vector, true_value_vector):
-    """
-    Create a vector of positive predictive values (PPV) for the prediction_vector using the true_value_vector as the true values.
-    """
-    df = pd.DataFrame({'prediction': prediction_vector, 'true_value': true_value_vector})
-    df.sort_values('prediction', ascending=True, inplace=True)
-    df['bin'] = pd.qcut(df['prediction'], 100, labels=False, duplicates=True, retbins=True)
-    for bin in df.bin.unique():
-        temp_df = df[df.bin >= bin].