wuepgg3-track 2.1.5 → 3.0.0

package/dist/assets/fetchGenomeAlignWorker-CsrbJZgd.js

@@ -1,72 +0,0 @@
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c=0;c<v;c++)s[d+c]=f[h+c]},flattenChunks:function(s){return[].concat.apply([],s)}};e.setTyped=function(s){s?(e.Buf8=Uint8Array,e.Buf16=Uint16Array,e.Buf32=Int32Array,e.assign(e,a)):(e.Buf8=Array,e.Buf16=Array,e.Buf32=Array,e.assign(e,o))},e.setTyped(n)})(lr);var da={},Jn={},ki={},Mp=lr,Pp=4,Hl=0,Zl=1,$p=2;function Ri(e){for(var n=e.length;--n>=0;)e[n]=0}var Up=0,Xl=1,Wp=2,qp=3,Gp=258,Xs=29,ga=256,pa=ga+1+Xs,Li=30,Vs=19,Vl=2*pa+1,ei=15,Ks=16,Hp=7,Ys=256,Kl=16,Yl=17,Ql=18,Qs=[0,0,0,0,0,0,0,0,1,1,1,1,2,2,2,2,3,3,3,3,4,4,4,4,5,5,5,5,0],cu=[0,0,0,0,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13],Zp=[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,3,7],Jl=[16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15],Xp=512,hr=new Array((pa+2)*2);Ri(hr);var _a=new Array(Li*2);Ri(_a);var va=new Array(Xp);Ri(va);var wa=new Array(Gp-qp+1);Ri(wa);var Js=new Array(Xs);Ri(Js);var du=new Array(Li);Ri(du);function js(e,n,t,a,o){this.static_tree=e,this.extra_bits=n,this.extra_base=t,this.elems=a,this.max_length=o,this.has_stree=e&&e.length}var jl,zl,e0;function zs(e,n){this.dyn_tree=e,this.max_code=0,this.stat_desc=n}function t0(e){return e<256?va[e]:va[256+(e>>>7)]}function ma(e,n){e.pending_buf[e.pending++]=n&255,e.pending_buf[e.pending++]=n>>>8&255}function zt(e,n,t){e.bi_valid>Ks-t?(e.bi_buf|=n<<e.bi_valid&65535,ma(e,e.bi_buf),e.bi_buf=n>>Ks-e.bi_valid,e.bi_valid+=t-Ks):(e.bi_buf|=n<<e.bi_valid&65535,e.bi_valid+=t)}function jn(e,n,t){zt(e,t[n*2],t[n*2+1])}function n0(e,n){var t=0;do t|=e&1,e>>>=1,t<<=1;while(--n>0);return t>>>1}function Vp(e){e.bi_valid===16?(ma(e,e.bi_buf),e.bi_buf=0,e.bi_valid=0):e.bi_valid>=8&&(e.pending_buf[e.pending++]=e.bi_buf&255,e.bi_buf>>=8,e.bi_valid-=8)}function Kp(e,n){var t=n.dyn_tree,a=n.max_code,o=n.stat_desc.static_tree,s=n.stat_desc.has_stree,f=n.stat_desc.extra_bits,h=n.stat_desc.extra_base,v=n.stat_desc.max_length,d,c,D,y,m,I,F=0;for(y=0;y<=ei;y++)e.bl_count[y]=0;for(t[e.heap[e.heap_max]*2+1]=0,d=e.heap_max+1;d<Vl;d++)c=e.heap[d],y=t[t[c*2+1]*2+1]+1,y>v&&(y=v,F++),t[c*2+1]=y,!(c>a)&&(e.bl_count[y]++,m=0,c>=h&&(m=f[c-h]),I=t[c*2],e.opt_len+=I*(y+m),s&&(e.static_len+=I*(o[c*2+1]+m)));if(F!==0){do{for(y=v-1;e.bl_count[y]===0;)y--;e.bl_count[y]--,e.bl_count[y+1]+=2,e.bl_count[v]--,F-=2}while(F>0);for(y=v;y!==0;y--)for(c=e.bl_count[y];c!==0;)D=e.heap[--d],!(D>a)&&(t[D*2+1]!==y&&(e.opt_len+=(y-t[D*2+1])*t[D*2],t[D*2+1]=y),c--)}}function r0(e,n,t){var a=new Array(ei+1),o=0,s,f;for(s=1;s<=ei;s++)a[s]=o=o+t[s-1]<<1;for(f=0;f<=n;f++){var h=e[f*2+1];h!==0&&(e[f*2]=n0(a[h]++,h))}}function Yp(){var e,n,t,a,o,s=new Array(ei+1);for(t=0,a=0;a<Xs-1;a++)for(Js[a]=t,e=0;e<1<<Qs[a];e++)wa[t++]=a;for(wa[t-1]=a,o=0,a=0;a<16;a++)for(du[a]=o,e=0;e<1<<cu[a];e++)va[o++]=a;for(o>>=7;a<Li;a++)for(du[a]=o<<7,e=0;e<1<<cu[a]-7;e++)va[256+o++]=a;for(n=0;n<=ei;n++)s[n]=0;for(e=0;e<=143;)hr[e*2+1]=8,e++,s[8]++;for(;e<=255;)hr[e*2+1]=9,e++,s[9]++;for(;e<=279;)hr[e*2+1]=7,e++,s[7]++;for(;e<=287;)hr[e*2+1]=8,e++,s[8]++;for(r0(hr,pa+1,s),e=0;e<Li;e++)_a[e*2+1]=5,_a[e*2]=n0(e,5);jl=new js(hr,Qs,ga+1,pa,ei),zl=new js(_a,cu,0,Li,ei),e0=new js(new Array(0),Zp,0,Vs,Hp)}function i0(e){var n;for(n=0;n<pa;n++)e.dyn_ltree[n*2]=0;for(n=0;n<Li;n++)e.dyn_dtree[n*2]=0;for(n=0;n<Vs;n++)e.bl_tree[n*2]=0;e.dyn_ltree[Ys*2]=1,e.opt_len=e.static_len=0,e.last_lit=e.matches=0}function a0(e){e.bi_valid>8?ma(e,e.bi_buf):e.bi_valid>0&&(e.pending_buf[e.pending++]=e.bi_buf),e.bi_buf=0,e.bi_valid=0}function Qp(e,n,t,a){a0(e),ma(e,t),ma(e,~t),Mp.arraySet(e.pending_buf,e.window,n,t,e.pending),e.pending+=t}function u0(e,n,t,a){var o=n*2,s=t*2;return 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h0(e,n,t,a){zt(e,(Up<<1)+(a?1:0),3),Qp(e,n,t)}function t_(e){zt(e,Xl<<1,3),jn(e,Ys,hr),Vp(e)}function n_(e,n,t,a){var o,s,f=0;e.level>0?(e.strm.data_type===$p&&(e.strm.data_type=zp(e)),to(e,e.l_desc),to(e,e.d_desc),f=Jp(e),o=e.opt_len+3+7>>>3,s=e.static_len+3+7>>>3,s<=o&&(o=s)):o=s=t+5,t+4<=o&&n!==-1?h0(e,n,t,a):e.strategy===Pp||s===o?(zt(e,(Xl<<1)+(a?1:0),3),s0(e,hr,_a)):(zt(e,(Wp<<1)+(a?1:0),3),jp(e,e.l_desc.max_code+1,e.d_desc.max_code+1,f+1),s0(e,e.dyn_ltree,e.dyn_dtree)),i0(e),a&&a0(e)}function r_(e,n,t){return e.pending_buf[e.d_buf+e.last_lit*2]=n>>>8&255,e.pending_buf[e.d_buf+e.last_lit*2+1]=n&255,e.pending_buf[e.l_buf+e.last_lit]=t&255,e.last_lit++,n===0?e.dyn_ltree[t*2]++:(e.matches++,n--,e.dyn_ltree[(wa[t]+ga+1)*2]++,e.dyn_dtree[t0(n)*2]++),e.last_lit===e.lit_bufsize-1}ki._tr_init=e_,ki._tr_stored_block=h0,ki._tr_flush_block=n_,ki._tr_tally=r_,ki._tr_align=t_;function i_(e,n,t,a){for(var o=e&65535|0,s=e>>>16&65535|0,f=0;t!==0;){f=t>2e3?2e3:t,t-=f;do 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n=e.state,t=n.pending;t>e.avail_out&&(t=e.avail_out),t!==0&&(Xt.arraySet(e.output,n.pending_buf,n.pending_out,t,e.next_out),e.next_out+=t,n.pending_out+=t,e.total_out+=t,e.avail_out-=t,n.pending-=t,n.pending===0&&(n.pending_out=0))}function Ut(e,n){bn._tr_flush_block(e,e.block_start>=0?e.block_start:-1,e.strstart-e.block_start,n),e.block_start=e.strstart,Mr(e.strm)}function Ze(e,n){e.pending_buf[e.pending++]=n}function xa(e,n){e.pending_buf[e.pending++]=n>>>8&255,e.pending_buf[e.pending++]=n&255}function S_(e,n,t,a){var o=e.avail_in;return o>a&&(o=a),o===0?0:(e.avail_in-=o,Xt.arraySet(n,e.input,e.next_in,o,t),e.state.wrap===1?e.adler=g0(e.adler,n,o,t):e.state.wrap===2&&(e.adler=kr(e.adler,n,o,t)),e.next_in+=o,e.total_in+=o,o)}function w0(e,n){var t=e.max_chain_length,a=e.strstart,o,s,f=e.prev_length,h=e.nice_match,v=e.strstart>e.w_size-$n?e.strstart-(e.w_size-$n):0,d=e.window,c=e.w_mask,D=e.prev,y=e.strstart+Lr,m=d[a+f-1],I=d[a+f];e.prev_length>=e.good_match&&(t>>=2),h>e.lookahead&&(h=e.lookahead);do if(o=n,!(d[o+f]!==I||d[o+f-1]!==m||d[o]!==d[a]||d[++o]!==d[a+1])){a+=2,o++;do;while(d[++a]===d[++o]&&d[++a]===d[++o]&&d[++a]===d[++o]&&d[++a]===d[++o]&&d[++a]===d[++o]&&d[++a]===d[++o]&&d[++a]===d[++o]&&d[++a]===d[++o]&&a<y);if(s=Lr-(y-a),a=y-Lr,s>f){if(e.match_start=n,f=s,s>=h)break;m=d[a+f-1],I=d[a+f]}}while((n=D[n&c])>v&&--t!==0);return f<=e.lookahead?f:e.lookahead}function ii(e){var n=e.w_size,t,a,o,s,f;do{if(s=e.window_size-e.lookahead-e.strstart,e.strstart>=n+(n-$n)){Xt.arraySet(e.window,e.window,n,n,0),e.match_start-=n,e.strstart-=n,e.block_start-=n,a=e.hash_size,t=a;do o=e.head[--t],e.head[t]=o>=n?o-n:0;while(--a);a=n,t=a;do o=e.prev[--t],e.prev[t]=o>=n?o-n:0;while(--a);s+=n}if(e.strm.avail_in===0)break;if(a=S_(e.strm,e.window,e.strstart+e.lookahead,s),e.lookahead+=a,e.lookahead+e.insert>=We)for(f=e.strstart-e.insert,e.ins_h=e.window[f],e.ins_h=(e.ins_h<<e.hash_shift^e.window[f+1])&e.hash_mask;e.insert&&(e.ins_h=(e.ins_h<<e.hash_shift^e.window[f+We-1])&e.hash_mask,e.prev[f&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=f,f++,e.insert--,!(e.lookahead+e.insert<We)););}while(e.lookahead<$n&&e.strm.avail_in!==0)}function I_(e,n){var t=65535;for(t>e.pending_buf_size-5&&(t=e.pending_buf_size-5);;){if(e.lookahead<=1){if(ii(e),e.lookahead===0&&n===ti)return Lt;if(e.lookahead===0)break}e.strstart+=e.lookahead,e.lookahead=0;var a=e.block_start+t;if((e.strstart===0||e.strstart>=a)&&(e.lookahead=e.strstart-a,e.strstart=a,Ut(e,!1),e.strm.avail_out===0)||e.strstart-e.block_start>=e.w_size-$n&&(Ut(e,!1),e.strm.avail_out===0))return Lt}return e.insert=0,n===Rr?(Ut(e,!0),e.strm.avail_out===0?ri:Ni):(e.strstart>e.block_start&&(Ut(e,!1),e.strm.avail_out===0),Lt)}function uo(e,n){for(var t,a;;){if(e.lookahead<$n){if(ii(e),e.lookahead<$n&&n===ti)return Lt;if(e.lookahead===0)break}if(t=0,e.lookahead>=We&&(e.ins_h=(e.ins_h<<e.hash_shift^e.window[e.strstart+We-1])&e.hash_mask,t=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart),t!==0&&e.strstart-t<=e.w_size-$n&&(e.match_length=w0(e,t)),e.match_length>=We)if(a=bn._tr_tally(e,e.strstart-e.match_start,e.match_length-We),e.lookahead-=e.match_length,e.match_length<=e.max_lazy_match&&e.lookahead>=We){e.match_length--;do e.strstart++,e.ins_h=(e.ins_h<<e.hash_shift^e.window[e.strstart+We-1])&e.hash_mask,t=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart;while(--e.match_length!==0);e.strstart++}else e.strstart+=e.match_length,e.match_length=0,e.ins_h=e.window[e.strstart],e.ins_h=(e.ins_h<<e.hash_shift^e.window[e.strstart+1])&e.hash_mask;else a=bn._tr_tally(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++;if(a&&(Ut(e,!1),e.strm.avail_out===0))return Lt}return e.insert=e.strstart<We-1?e.strstart:We-1,n===Rr?(Ut(e,!0),e.strm.avail_out===0?ri:Ni):e.last_lit&&(Ut(e,!1),e.strm.avail_out===0)?Lt:Da}function Oi(e,n){for(var t,a,o;;){if(e.lookahead<$n){if(ii(e),e.lookahead<$n&&n===ti)return Lt;if(e.lookahead===0)break}if(t=0,e.lookahead>=We&&(e.ins_h=(e.ins_h<<e.hash_shift^e.window[e.strstart+We-1])&e.hash_mask,t=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart),e.prev_length=e.match_length,e.prev_match=e.match_start,e.match_length=We-1,t!==0&&e.prev_length<e.max_lazy_match&&e.strstart-t<=e.w_size-$n&&(e.match_length=w0(e,t),e.match_length<=5&&(e.strategy===d_||e.match_length===We&&e.strstart-e.match_start>4096)&&(e.match_length=We-1)),e.prev_length>=We&&e.match_length<=e.prev_length){o=e.strstart+e.lookahead-We,a=bn._tr_tally(e,e.strstart-1-e.prev_match,e.prev_length-We),e.lookahead-=e.prev_length-1,e.prev_length-=2;do++e.strstart<=o&&(e.ins_h=(e.ins_h<<e.hash_shift^e.window[e.strstart+We-1])&e.hash_mask,t=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart);while(--e.prev_length!==0);if(e.match_available=0,e.match_length=We-1,e.strstart++,a&&(Ut(e,!1),e.strm.avail_out===0))return Lt}else if(e.match_available){if(a=bn._tr_tally(e,0,e.window[e.strstart-1]),a&&Ut(e,!1),e.strstart++,e.lookahead--,e.strm.avail_out===0)return Lt}else e.match_available=1,e.strstart++,e.lookahead--}return e.match_available&&(a=bn._tr_tally(e,0,e.window[e.strstart-1]),e.match_available=0),e.insert=e.strstart<We-1?e.strstart:We-1,n===Rr?(Ut(e,!0),e.strm.avail_out===0?ri:Ni):e.last_lit&&(Ut(e,!1),e.strm.avail_out===0)?Lt:Da}function T_(e,n){for(var t,a,o,s,f=e.window;;){if(e.lookahead<=Lr){if(ii(e),e.lookahead<=Lr&&n===ti)return Lt;if(e.lookahead===0)break}if(e.match_length=0,e.lookahead>=We&&e.strstart>0&&(o=e.strstart-1,a=f[o],a===f[++o]&&a===f[++o]&&a===f[++o])){s=e.strstart+Lr;do;while(a===f[++o]&&a===f[++o]&&a===f[++o]&&a===f[++o]&&a===f[++o]&&a===f[++o]&&a===f[++o]&&a===f[++o]&&o<s);e.match_length=Lr-(s-o),e.match_length>e.lookahead&&(e.match_length=e.lookahead)}if(e.match_length>=We?(t=bn._tr_tally(e,1,e.match_length-We),e.lookahead-=e.match_length,e.strstart+=e.match_length,e.match_length=0):(t=bn._tr_tally(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++),t&&(Ut(e,!1),e.strm.avail_out===0))return Lt}return e.insert=0,n===Rr?(Ut(e,!0),e.strm.avail_out===0?ri:Ni):e.last_lit&&(Ut(e,!1),e.strm.avail_out===0)?Lt:Da}function k_(e,n){for(var t;;){if(e.lookahead===0&&(ii(e),e.lookahead===0)){if(n===ti)return Lt;break}if(e.match_length=0,t=bn._tr_tally(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++,t&&(Ut(e,!1),e.strm.avail_out===0))return Lt}return e.insert=0,n===Rr?(Ut(e,!0),e.strm.avail_out===0?ri:Ni):e.last_lit&&(Ut(e,!1),e.strm.avail_out===0)?Lt:Da}function er(e,n,t,a,o){this.good_length=e,this.max_lazy=n,this.nice_length=t,this.max_chain=a,this.func=o}var Mi;Mi=[new er(0,0,0,0,I_),new er(4,4,8,4,uo),new er(4,5,16,8,uo),new er(4,6,32,32,uo),new er(4,4,16,16,Oi),new er(8,16,32,32,Oi),new er(8,16,128,128,Oi),new er(8,32,128,256,Oi),new er(32,128,258,1024,Oi),new er(32,258,258,4096,Oi)];function R_(e){e.window_size=2*e.w_size,Or(e.head),e.max_lazy_match=Mi[e.level].max_lazy,e.good_match=Mi[e.level].good_length,e.nice_match=Mi[e.level].nice_length,e.max_chain_length=Mi[e.level].max_chain,e.strstart=0,e.block_start=0,e.lookahead=0,e.insert=0,e.match_length=e.prev_length=We-1,e.match_available=0,e.ins_h=0}function L_(){this.strm=null,this.status=0,this.pending_buf=null,this.pending_buf_size=0,this.pending_out=0,this.pending=0,this.wrap=0,this.gzhead=null,this.gzindex=0,this.method=pu,this.last_flush=-1,this.w_size=0,this.w_bits=0,this.w_mask=0,this.window=null,this.window_size=0,this.prev=null,this.head=null,this.ins_h=0,this.hash_size=0,this.hash_bits=0,this.hash_mask=0,this.hash_shift=0,this.block_start=0,this.match_length=0,this.prev_match=0,this.match_available=0,this.strstart=0,this.match_start=0,this.lookahead=0,this.prev_length=0,this.max_chain_length=0,this.max_lazy_match=0,this.level=0,this.strategy=0,this.good_match=0,this.nice_match=0,this.dyn_ltree=new Xt.Buf16(A_*2),this.dyn_dtree=new Xt.Buf16((2*y_+1)*2),this.bl_tree=new Xt.Buf16((2*E_+1)*2),Or(this.dyn_ltree),Or(this.dyn_dtree),Or(this.bl_tree),this.l_desc=null,this.d_desc=null,this.bl_desc=null,this.bl_count=new Xt.Buf16(F_+1),this.heap=new Xt.Buf16(2*io+1),Or(this.heap),this.heap_len=0,this.heap_max=0,this.depth=new Xt.Buf16(2*io+1),Or(this.depth),this.l_buf=0,this.lit_bufsize=0,this.last_lit=0,this.d_buf=0,this.opt_len=0,this.static_len=0,this.matches=0,this.insert=0,this.bi_buf=0,this.bi_valid=0}function m0(e){var n;return!e||!e.state?Nr(e,Dn):(e.total_in=e.total_out=0,e.data_type=v_,n=e.state,n.pending=0,n.pending_out=0,n.wrap<0&&(n.wrap=-n.wrap),n.status=n.wrap?_u:ni,e.adler=n.wrap===2?0:1,n.last_flush=ti,bn._tr_init(n),zn)}function b0(e){var n=m0(e);return n===zn&&R_(e.state),n}function N_(e,n){return!e||!e.state||e.state.wrap!==2?Dn:(e.state.gzhead=n,zn)}function D0(e,n,t,a,o,s){if(!e)return Dn;var f=1;if(n===c_&&(n=6),a<0?(f=0,a=-a):a>15&&(f=2,a-=16),o<1||o>w_||t!==pu||a<8||a>15||n<0||n>9||s<0||s>p_)return Nr(e,Dn);a===8&&(a=9);var h=new L_;return e.state=h,h.strm=e,h.wrap=f,h.gzhead=null,h.w_bits=a,h.w_size=1<<h.w_bits,h.w_mask=h.w_size-1,h.hash_bits=o+7,h.hash_size=1<<h.hash_bits,h.hash_mask=h.hash_size-1,h.hash_shift=~~((h.hash_bits+We-1)/We),h.window=new Xt.Buf8(h.w_size*2),h.head=new Xt.Buf16(h.hash_size),h.prev=new Xt.Buf16(h.w_size),h.lit_bufsize=1<<o+6,h.pending_buf_size=h.lit_bufsize*4,h.pending_buf=new Xt.Buf8(h.pending_buf_size),h.d_buf=1*h.lit_bufsize,h.l_buf=3*h.lit_bufsize,h.level=n,h.strategy=s,h.method=t,b0(e)}function O_(e,n){return D0(e,n,pu,m_,b_,__)}function M_(e,n){var t,a,o,s;if(!e||!e.state||n>p0||n<0)return e?Nr(e,Dn):Dn;if(a=e.state,!e.output||!e.input&&e.avail_in!==0||a.status===ba&&n!==Rr)return Nr(e,e.avail_out===0?ro:Dn);if(a.strm=e,t=a.last_flush,a.last_flush=n,a.status===_u)if(a.wrap===2)e.adler=0,Ze(a,31),Ze(a,139),Ze(a,8),a.gzhead?(Ze(a,(a.gzhead.text?1:0)+(a.gzhead.hcrc?2:0)+(a.gzhead.extra?4:0)+(a.gzhead.name?8:0)+(a.gzhead.comment?16:0)),Ze(a,a.gzhead.time&255),Ze(a,a.gzhead.time>>8&255),Ze(a,a.gzhead.time>>16&255),Ze(a,a.gzhead.time>>24&255),Ze(a,a.level===9?2:a.strategy>=gu||a.level<2?4:0),Ze(a,a.gzhead.os&255),a.gzhead.extra&&a.gzhead.extra.length&&(Ze(a,a.gzhead.extra.length&255),Ze(a,a.gzhead.extra.length>>8&255)),a.gzhead.hcrc&&(e.adler=kr(e.adler,a.pending_buf,a.pending,0)),a.gzindex=0,a.status=ao):(Ze(a,0),Ze(a,0),Ze(a,0),Ze(a,0),Ze(a,0),Ze(a,a.level===9?2:a.strategy>=gu||a.level<2?4:0),Ze(a,B_),a.status=ni);else{var f=pu+(a.w_bits-8<<4)<<8,h=-1;a.strategy>=gu||a.level<2?h=0:a.level<6?h=1:a.level===6?h=2:h=3,f|=h<<6,a.strstart!==0&&(f|=C_),f+=31-f%31,a.status=ni,xa(a,f),a.strstart!==0&&(xa(a,e.adler>>>16),xa(a,e.adler&65535)),e.adler=1}if(a.status===ao)if(a.gzhead.extra){for(o=a.pending;a.gzindex<(a.gzhead.extra.length&65535)&&!(a.pending===a.pending_buf_size&&(a.gzhead.hcrc&&a.pending>o&&(e.adler=kr(e.adler,a.pending_buf,a.pending-o,o)),Mr(e),o=a.pending,a.pending===a.pending_buf_size));)Ze(a,a.gzhead.extra[a.gzindex]&255),a.gzindex++;a.gzhead.hcrc&&a.pending>o&&(e.adler=kr(e.adler,a.pending_buf,a.pending-o,o)),a.gzindex===a.gzhead.extra.length&&(a.gzindex=0,a.status=vu)}else a.status=vu;if(a.status===vu)if(a.gzhead.name){o=a.pending;do{if(a.pending===a.pending_buf_size&&(a.gzhead.hcrc&&a.pending>o&&(e.adler=kr(e.adler,a.pending_buf,a.pending-o,o)),Mr(e),o=a.pending,a.pending===a.pending_buf_size)){s=1;break}a.gzindex<a.gzhead.name.length?s=a.gzhead.name.charCodeAt(a.gzindex++)&255:s=0,Ze(a,s)}while(s!==0);a.gzhead.hcrc&&a.pending>o&&(e.adler=kr(e.adler,a.pending_buf,a.pending-o,o)),s===0&&(a.gzindex=0,a.status=wu)}else a.status=wu;if(a.status===wu)if(a.gzhead.comment){o=a.pending;do{if(a.pending===a.pending_buf_size&&(a.gzhead.hcrc&&a.pending>o&&(e.adler=kr(e.adler,a.pending_buf,a.pending-o,o)),Mr(e),o=a.pending,a.pending===a.pending_buf_size)){s=1;break}a.gzindex<a.gzhead.comment.length?s=a.gzhead.comment.charCodeAt(a.gzindex++)&255:s=0,Ze(a,s)}while(s!==0);a.gzhead.hcrc&&a.pending>o&&(e.adler=kr(e.adler,a.pending_buf,a.pending-o,o)),s===0&&(a.status=mu)}else a.status=mu;if(a.status===mu&&(a.gzhead.hcrc?(a.pending+2>a.pending_buf_size&&Mr(e),a.pending+2<=a.pending_buf_size&&(Ze(a,e.adler&255),Ze(a,e.adler>>8&255),e.adler=0,a.status=ni)):a.status=ni),a.pending!==0){if(Mr(e),e.avail_out===0)return a.last_flush=-1,zn}else if(e.avail_in===0&&v0(n)<=v0(t)&&n!==Rr)return Nr(e,ro);if(a.status===ba&&e.avail_in!==0)return Nr(e,ro);if(e.avail_in!==0||a.lookahead!==0||n!==ti&&a.status!==ba){var v=a.strategy===gu?k_(a,n):a.strategy===g_?T_(a,n):Mi[a.level].func(a,n);if((v===ri||v===Ni)&&(a.status=ba),v===Lt||v===ri)return e.avail_out===0&&(a.last_flush=-1),zn;if(v===Da&&(n===f_?bn._tr_align(a):n!==p0&&(bn._tr_stored_block(a,0,0,!1),n===l_&&(Or(a.head),a.lookahead===0&&(a.strstart=0,a.block_start=0,a.insert=0))),Mr(e),e.avail_out===0))return a.last_flush=-1,zn}return n!==Rr?zn:a.wrap<=0?_0:(a.wrap===2?(Ze(a,e.adler&255),Ze(a,e.adler>>8&255),Ze(a,e.adler>>16&255),Ze(a,e.adler>>24&255),Ze(a,e.total_in&255),Ze(a,e.total_in>>8&255),Ze(a,e.total_in>>16&255),Ze(a,e.total_in>>24&255)):(xa(a,e.adler>>>16),xa(a,e.adler&65535)),Mr(e),a.wrap>0&&(a.wrap=-a.wrap),a.pending!==0?zn:_0)}function P_(e){var n;return!e||!e.state?Dn:(n=e.state.status,n!==_u&&n!==ao&&n!==vu&&n!==wu&&n!==mu&&n!==ni&&n!==ba?Nr(e,Dn):(e.state=null,n===ni?Nr(e,h_):zn))}function $_(e,n){var t=n.length,a,o,s,f,h,v,d,c;if(!e||!e.state||(a=e.state,f=a.wrap,f===2||f===1&&a.status!==_u||a.lookahead))return Dn;for(f===1&&(e.adler=g0(e.adler,n,t,0)),a.wrap=0,t>=a.w_size&&(f===0&&(Or(a.head),a.strstart=0,a.block_start=0,a.insert=0),c=new Xt.Buf8(a.w_size),Xt.arraySet(c,n,t-a.w_size,a.w_size,0),n=c,t=a.w_size),h=e.avail_in,v=e.next_in,d=e.input,e.avail_in=t,e.next_in=0,e.input=n,ii(a);a.lookahead>=We;){o=a.strstart,s=a.lookahead-(We-1);do a.ins_h=(a.ins_h<<a.hash_shift^a.window[o+We-1])&a.hash_mask,a.prev[o&a.w_mask]=a.head[a.ins_h],a.head[a.ins_h]=o,o++;while(--s);a.strstart=o,a.lookahead=We-1,ii(a)}return a.strstart+=a.lookahead,a.block_start=a.strstart,a.insert=a.lookahead,a.lookahead=0,a.match_length=a.prev_length=We-1,a.match_available=0,e.next_in=v,e.input=d,e.avail_in=h,a.wrap=f,zn}Jn.deflateInit=O_,Jn.deflateInit2=D0,Jn.deflateReset=b0,Jn.deflateResetKeep=m0,Jn.deflateSetHeader=N_,Jn.deflate=M_,Jn.deflateEnd=P_,Jn.deflateSetDictionary=$_,Jn.deflateInfo="pako deflate (from Nodeca project)";var ai={},bu=lr,x0=!0,y0=!0;try{String.fromCharCode.apply(null,[0])}catch{x0=!1}try{String.fromCharCode.apply(null,new Uint8Array(1))}catch{y0=!1}for(var ya=new bu.Buf8(256),Pr=0;Pr<256;Pr++)ya[Pr]=Pr>=252?6:Pr>=248?5:Pr>=240?4:Pr>=224?3:Pr>=192?2:1;ya[254]=ya[254]=1,ai.string2buf=function(e){var n,t,a,o,s,f=e.length,h=0;for(o=0;o<f;o++)t=e.charCodeAt(o),(t&64512)===55296&&o+1<f&&(a=e.charCodeAt(o+1),(a&64512)===56320&&(t=65536+(t-55296<<10)+(a-56320),o++)),h+=t<128?1:t<2048?2:t<65536?3:4;for(n=new bu.Buf8(h),s=0,o=0;s<h;o++)t=e.charCodeAt(o),(t&64512)===55296&&o+1<f&&(a=e.charCodeAt(o+1),(a&64512)===56320&&(t=65536+(t-55296<<10)+(a-56320),o++)),t<128?n[s++]=t:t<2048?(n[s++]=192|t>>>6,n[s++]=128|t&63):t<65536?(n[s++]=224|t>>>12,n[s++]=128|t>>>6&63,n[s++]=128|t&63):(n[s++]=240|t>>>18,n[s++]=128|t>>>12&63,n[s++]=128|t>>>6&63,n[s++]=128|t&63);return n};function E0(e,n){if(n<65534&&(e.subarray&&y0||!e.subarray&&x0))return String.fromCharCode.apply(null,bu.shrinkBuf(e,n));for(var t="",a=0;a<n;a++)t+=String.fromCharCode(e[a]);return t}ai.buf2binstring=function(e){return E0(e,e.length)},ai.binstring2buf=function(e){for(var n=new bu.Buf8(e.length),t=0,a=n.length;t<a;t++)n[t]=e.charCodeAt(t);return n},ai.buf2string=function(e,n){var t,a,o,s,f=n||e.length,h=new 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n=this.options;n.raw&&n.windowBits>0?n.windowBits=-n.windowBits:n.gzip&&n.windowBits>0&&n.windowBits<16&&(n.windowBits+=16),this.err=0,this.msg="",this.ended=!1,this.chunks=[],this.strm=new W_,this.strm.avail_out=0;var t=Ea.deflateInit2(this.strm,n.level,n.method,n.windowBits,n.memLevel,n.strategy);if(t!==Pi)throw new Error(oo[t]);if(n.header&&Ea.deflateSetHeader(this.strm,n.header),n.dictionary){var a;if(typeof n.dictionary=="string"?a=so.string2buf(n.dictionary):F0.call(n.dictionary)==="[object ArrayBuffer]"?a=new Uint8Array(n.dictionary):a=n.dictionary,t=Ea.deflateSetDictionary(this.strm,a),t!==Pi)throw new Error(oo[t]);this._dict_set=!0}}ui.prototype.push=function(e,n){var t=this.strm,a=this.options.chunkSize,o,s;if(this.ended)return!1;s=n===~~n?n:n===!0?fo:q_,typeof e=="string"?t.input=so.string2buf(e):F0.call(e)==="[object ArrayBuffer]"?t.input=new Uint8Array(e):t.input=e,t.next_in=0,t.avail_in=t.input.length;do{if(t.avail_out===0&&(t.output=new Aa.Buf8(a),t.next_out=0,t.avail_out=a),o=Ea.deflate(t,s),o!==C0&&o!==Pi)return this.onEnd(o),this.ended=!0,!1;(t.avail_out===0||t.avail_in===0&&(s===fo||s===B0))&&(this.options.to==="string"?this.onData(so.buf2binstring(Aa.shrinkBuf(t.output,t.next_out))):this.onData(Aa.shrinkBuf(t.output,t.next_out)))}while((t.avail_in>0||t.avail_out===0)&&o!==C0);return s===fo?(o=Ea.deflateEnd(this.strm),this.onEnd(o),this.ended=!0,o===Pi):(s===B0&&(this.onEnd(Pi),t.avail_out=0),!0)},ui.prototype.onData=function(e){this.chunks.push(e)},ui.prototype.onEnd=function(e){e===Pi&&(this.options.to==="string"?this.result=this.chunks.join(""):this.result=Aa.flattenChunks(this.chunks)),this.chunks=[],this.err=e,this.msg=this.strm.msg};function lo(e,n){var t=new ui(n);if(t.push(e,!0),t.err)throw t.msg||oo[t.err];return t.result}function X_(e,n){return n=n||{},n.raw=!0,lo(e,n)}function V_(e,n){return n=n||{},n.gzip=!0,lo(e,n)}da.Deflate=ui,da.deflate=lo,da.deflateRaw=X_,da.gzip=V_;var 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s[f++]=1<<24|64<<16|0,s[f++]=1<<24|64<<16|0,v.bits=1,0;for(y=1;y<m&&V[y]===0;y++);for(I<y&&(I=y),L=1,c=1;c<=$i;c++)if(L<<=1,L-=V[c],L<0)return-1;if(L>0&&(n===k0||m!==1))return-1;for(te[1]=0,c=1;c<$i;c++)te[c+1]=te[c]+V[c];for(D=0;D<o;D++)t[a+D]!==0&&(h[te[t[a+D]]++]=D);if(n===k0?(S=ie=h,W=19):n===ho?(S=Q_,O-=257,ie=J_,le-=257,W=256):(S=j_,ie=z_,W=-1),P=0,D=0,c=y,C=f,F=I,k=0,q=-1,G=1<<I,N=G-1,n===ho&&G>I0||n===R0&&G>T0)return 1;for(;;){Fe=c-k,h[D]<W?(ae=0,pe=h[D]):h[D]>W?(ae=ie[le+h[D]],pe=S[O+h[D]]):(ae=96,pe=0),T=1<<c-k,$=1<<F,y=$;do $-=T,s[C+(P>>k)+$]=Fe<<24|ae<<16|pe|0;while($!==0);for(T=1<<c-1;P&T;)T>>=1;if(T!==0?(P&=T-1,P+=T):P=0,D++,--V[c]===0){if(c===m)break;c=t[a+h[D]]}if(c>I&&(P&N)!==q){for(k===0&&(k=I),C+=y,F=c-k,L=1<<F;F+k<m&&(L-=V[F+k],!(L<=0));)F++,L<<=1;if(G+=1<<F,n===ho&&G>I0||n===R0&&G>T0)return 1;q=P&N,s[q]=I<<24|F<<16|C-f|0}}return P!==0&&(s[C+P]=c-k<<24|64<<16|0),v.bits=I,0},fn=lr,co=c0,tr=d0,t2=Y_,Ca=e2,n2=0,L0=1,N0=2,O0=4,r2=5,xu=6,si=0,i2=1,a2=2,xn=-2,M0=-3,P0=-4,u2=-5,$0=8,U0=1,W0=2,q0=3,G0=4,H0=5,Z0=6,X0=7,V0=8,K0=9,Y0=10,yu=11,cr=12,go=13,Q0=14,po=15,J0=16,j0=17,z0=18,eh=19,Eu=20,Au=21,th=22,nh=23,rh=24,ih=25,ah=26,_o=27,uh=28,sh=29,pt=30,oh=31,s2=32,o2=852,f2=592,l2=15,h2=l2;function fh(e){return(e>>>24&255)+(e>>>8&65280)+((e&65280)<<8)+((e&255)<<24)}function c2(){this.mode=0,this.last=!1,this.wrap=0,this.havedict=!1,this.flags=0,this.dmax=0,this.check=0,this.total=0,this.head=null,this.wbits=0,this.wsize=0,this.whave=0,this.wnext=0,this.window=null,this.hold=0,this.bits=0,this.length=0,this.offset=0,this.extra=0,this.lencode=null,this.distcode=null,this.lenbits=0,this.distbits=0,this.ncode=0,this.nlen=0,this.ndist=0,this.have=0,this.next=null,this.lens=new fn.Buf16(320),this.work=new fn.Buf16(288),this.lendyn=null,this.distdyn=null,this.sane=0,this.back=0,this.was=0}function lh(e){var n;return!e||!e.state?xn:(n=e.state,e.total_in=e.total_out=n.total=0,e.msg="",n.wrap&&(e.adler=n.wrap&1),n.mode=U0,n.last=0,n.havedict=0,n.dmax=32768,n.head=null,n.hold=0,n.bits=0,n.lencode=n.lendyn=new fn.Buf32(o2),n.distcode=n.distdyn=new fn.Buf32(f2),n.sane=1,n.back=-1,si)}function hh(e){var n;return!e||!e.state?xn:(n=e.state,n.wsize=0,n.whave=0,n.wnext=0,lh(e))}function ch(e,n){var t,a;return!e||!e.state||(a=e.state,n<0?(t=0,n=-n):(t=(n>>4)+1,n<48&&(n&=15)),n&&(n<8||n>15))?xn:(a.window!==null&&a.wbits!==n&&(a.window=null),a.wrap=t,a.wbits=n,hh(e))}function dh(e,n){var t,a;return e?(a=new c2,e.state=a,a.window=null,t=ch(e,n),t!==si&&(e.state=null),t):xn}function d2(e){return dh(e,h2)}var gh=!0,vo,wo;function g2(e){if(gh){var n;for(vo=new fn.Buf32(512),wo=new fn.Buf32(32),n=0;n<144;)e.lens[n++]=8;for(;n<256;)e.lens[n++]=9;for(;n<280;)e.lens[n++]=7;for(;n<288;)e.lens[n++]=8;for(Ca(L0,e.lens,0,288,vo,0,e.work,{bits:9}),n=0;n<32;)e.lens[n++]=5;Ca(N0,e.lens,0,32,wo,0,e.work,{bits:5}),gh=!1}e.lencode=vo,e.lenbits=9,e.distcode=wo,e.distbits=5}function ph(e,n,t,a){var o,s=e.state;return s.window===null&&(s.wsize=1<<s.wbits,s.wnext=0,s.whave=0,s.window=new fn.Buf8(s.wsize)),a>=s.wsize?(fn.arraySet(s.window,n,t-s.wsize,s.wsize,0),s.wnext=0,s.whave=s.wsize):(o=s.wsize-s.wnext,o>a&&(o=a),fn.arraySet(s.window,n,t-a,o,s.wnext),a-=o,a?(fn.arraySet(s.window,n,t-a,a,0),s.wnext=a,s.whave=s.wsize):(s.wnext+=o,s.wnext===s.wsize&&(s.wnext=0),s.whave<s.wsize&&(s.whave+=o))),0}function p2(e,n){var t,a,o,s,f,h,v,d,c,D,y,m,I,F,k=0,L,G,P,T,$,q,N,C,S=new fn.Buf8(4),O,W,V=[16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15];if(!e||!e.state||!e.output||!e.input&&e.avail_in!==0)return xn;t=e.state,t.mode===cr&&(t.mode=go),f=e.next_out,o=e.output,v=e.avail_out,s=e.next_in,a=e.input,h=e.avail_in,d=t.hold,c=t.bits,D=h,y=v,C=si;e:for(;;)switch(t.mode){case U0:if(t.wrap===0){t.mode=go;break}for(;c<16;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(t.wrap&2&&d===35615){t.check=0,S[0]=d&255,S[1]=d>>>8&255,t.check=tr(t.check,S,2,0),d=0,c=0,t.mode=W0;break}if(t.flags=0,t.head&&(t.head.done=!1),!(t.wrap&1)||(((d&255)<<8)+(d>>8))%31){e.msg="incorrect header check",t.mode=pt;break}if((d&15)!==$0){e.msg="unknown compression method",t.mode=pt;break}if(d>>>=4,c-=4,N=(d&15)+8,t.wbits===0)t.wbits=N;else if(N>t.wbits){e.msg="invalid window size",t.mode=pt;break}t.dmax=1<<N,e.adler=t.check=1,t.mode=d&512?Y0:cr,d=0,c=0;break;case W0:for(;c<16;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(t.flags=d,(t.flags&255)!==$0){e.msg="unknown compression method",t.mode=pt;break}if(t.flags&57344){e.msg="unknown header flags 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e;h--,d+=a[s++]<<c,c+=8}e.adler=t.check=fh(d),d=0,c=0,t.mode=yu;case yu:if(t.havedict===0)return e.next_out=f,e.avail_out=v,e.next_in=s,e.avail_in=h,t.hold=d,t.bits=c,a2;e.adler=t.check=1,t.mode=cr;case cr:if(n===r2||n===xu)break e;case go:if(t.last){d>>>=c&7,c-=c&7,t.mode=_o;break}for(;c<3;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}switch(t.last=d&1,d>>>=1,c-=1,d&3){case 0:t.mode=Q0;break;case 1:if(g2(t),t.mode=Eu,n===xu){d>>>=2,c-=2;break e}break;case 2:t.mode=j0;break;case 3:e.msg="invalid block type",t.mode=pt}d>>>=2,c-=2;break;case Q0:for(d>>>=c&7,c-=c&7;c<32;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if((d&65535)!==(d>>>16^65535)){e.msg="invalid stored block lengths",t.mode=pt;break}if(t.length=d&65535,d=0,c=0,t.mode=po,n===xu)break e;case po:t.mode=J0;case J0:if(m=t.length,m){if(m>h&&(m=h),m>v&&(m=v),m===0)break e;fn.arraySet(o,a,s,m,f),h-=m,s+=m,v-=m,f+=m,t.length-=m;break}t.mode=cr;break;case j0:for(;c<14;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(t.nlen=(d&31)+257,d>>>=5,c-=5,t.ndist=(d&31)+1,d>>>=5,c-=5,t.ncode=(d&15)+4,d>>>=4,c-=4,t.nlen>286||t.ndist>30){e.msg="too many length or distance symbols",t.mode=pt;break}t.have=0,t.mode=z0;case z0:for(;t.have<t.ncode;){for(;c<3;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}t.lens[V[t.have++]]=d&7,d>>>=3,c-=3}for(;t.have<19;)t.lens[V[t.have++]]=0;if(t.lencode=t.lendyn,t.lenbits=7,O={bits:t.lenbits},C=Ca(n2,t.lens,0,19,t.lencode,0,t.work,O),t.lenbits=O.bits,C){e.msg="invalid code lengths set",t.mode=pt;break}t.have=0,t.mode=eh;case eh:for(;t.have<t.nlen+t.ndist;){for(;k=t.lencode[d&(1<<t.lenbits)-1],L=k>>>24,G=k>>>16&255,P=k&65535,!(L<=c);){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(P<16)d>>>=L,c-=L,t.lens[t.have++]=P;else{if(P===16){for(W=L+2;c<W;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(d>>>=L,c-=L,t.have===0){e.msg="invalid bit length repeat",t.mode=pt;break}N=t.lens[t.have-1],m=3+(d&3),d>>>=2,c-=2}else if(P===17){for(W=L+3;c<W;){if(h===0)break 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Au:if(h>=6&&v>=258){e.next_out=f,e.avail_out=v,e.next_in=s,e.avail_in=h,t.hold=d,t.bits=c,t2(e,y),f=e.next_out,o=e.output,v=e.avail_out,s=e.next_in,a=e.input,h=e.avail_in,d=t.hold,c=t.bits,t.mode===cr&&(t.back=-1);break}for(t.back=0;k=t.lencode[d&(1<<t.lenbits)-1],L=k>>>24,G=k>>>16&255,P=k&65535,!(L<=c);){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(G&&!(G&240)){for(T=L,$=G,q=P;k=t.lencode[q+((d&(1<<T+$)-1)>>T)],L=k>>>24,G=k>>>16&255,P=k&65535,!(T+L<=c);){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}d>>>=T,c-=T,t.back+=T}if(d>>>=L,c-=L,t.back+=L,t.length=P,G===0){t.mode=ah;break}if(G&32){t.back=-1,t.mode=cr;break}if(G&64){e.msg="invalid literal/length code",t.mode=pt;break}t.extra=G&15,t.mode=th;case th:if(t.extra){for(W=t.extra;c<W;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}t.length+=d&(1<<t.extra)-1,d>>>=t.extra,c-=t.extra,t.back+=t.extra}t.was=t.length,t.mode=nh;case nh:for(;k=t.distcode[d&(1<<t.distbits)-1],L=k>>>24,G=k>>>16&255,P=k&65535,!(L<=c);){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(!(G&240)){for(T=L,$=G,q=P;k=t.distcode[q+((d&(1<<T+$)-1)>>T)],L=k>>>24,G=k>>>16&255,P=k&65535,!(T+L<=c);){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}d>>>=T,c-=T,t.back+=T}if(d>>>=L,c-=L,t.back+=L,G&64){e.msg="invalid distance code",t.mode=pt;break}t.offset=P,t.extra=G&15,t.mode=rh;case rh:if(t.extra){for(W=t.extra;c<W;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}t.offset+=d&(1<<t.extra)-1,d>>>=t.extra,c-=t.extra,t.back+=t.extra}if(t.offset>t.dmax){e.msg="invalid distance too far back",t.mode=pt;break}t.mode=ih;case ih:if(v===0)break e;if(m=y-v,t.offset>m){if(m=t.offset-m,m>t.whave&&t.sane){e.msg="invalid distance too far back",t.mode=pt;break}m>t.wnext?(m-=t.wnext,I=t.wsize-m):I=t.wnext-m,m>t.length&&(m=t.length),F=t.window}else F=o,I=f-t.offset,m=t.length;m>v&&(m=v),v-=m,t.length-=m;do o[f++]=F[I++];while(--m);t.length===0&&(t.mode=Au);break;case ah:if(v===0)break e;o[f++]=t.length,v--,t.mode=Au;break;case _o:if(t.wrap){for(;c<32;){if(h===0)break e;h--,d|=a[s++]<<c,c+=8}if(y-=v,e.total_out+=y,t.total+=y,y&&(e.adler=t.check=t.flags?tr(t.check,o,y,f-y):co(t.check,o,y,f-y)),y=v,(t.flags?d:fh(d))!==t.check){e.msg="incorrect data check",t.mode=pt;break}d=0,c=0}t.mode=uh;case uh:if(t.wrap&&t.flags){for(;c<32;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(d!==(t.total&4294967295)){e.msg="incorrect length check",t.mode=pt;break}d=0,c=0}t.mode=sh;case sh:C=i2;break e;case pt:C=M0;break e;case oh:return P0;case s2:default:return xn}return e.next_out=f,e.avail_out=v,e.next_in=s,e.avail_in=h,t.hold=d,t.bits=c,(t.wsize||y!==e.avail_out&&t.mode<pt&&(t.mode<_o||n!==O0))&&ph(e,e.output,e.next_out,y-e.avail_out),D-=e.avail_in,y-=e.avail_out,e.total_in+=D,e.total_out+=y,t.total+=y,t.wrap&&y&&(e.adler=t.check=t.flags?tr(t.check,o,y,e.next_out-y):co(t.check,o,y,e.next_out-y)),e.data_type=t.bits+(t.last?64:0)+(t.mode===cr?128:0)+(t.mode===Eu||t.mode===po?256:0),(D===0&&y===0||n===O0)&&C===si&&(C=u2),C}function _2(e){if(!e||!e.state)return xn;var n=e.state;return n.window&&(n.window=null),e.state=null,si}function v2(e,n){var t;return!e||!e.state||(t=e.state,!(t.wrap&2))?xn:(t.head=n,n.done=!1,si)}function w2(e,n){var t=n.length,a,o,s;return!e||!e.state||(a=e.state,a.wrap!==0&&a.mode!==yu)?xn:a.mode===yu&&(o=1,o=co(o,n,t,0),o!==a.check)?M0:(s=ph(e,n,t,t),s?(a.mode=oh,P0):(a.havedict=1,si))}Un.inflateReset=hh,Un.inflateReset2=ch,Un.inflateResetKeep=lh,Un.inflateInit=d2,Un.inflateInit2=dh,Un.inflate=p2,Un.inflateEnd=_2,Un.inflateGetHeader=v2,Un.inflateSetDictionary=w2,Un.inflateInfo="pako inflate (from Nodeca project)";var _h={Z_NO_FLUSH:0,Z_PARTIAL_FLUSH:1,Z_SYNC_FLUSH:2,Z_FULL_FLUSH:3,Z_FINISH:4,Z_BLOCK:5,Z_TREES:6,Z_OK:0,Z_STREAM_END:1,Z_NEED_DICT:2,Z_ERRNO:-1,Z_STREAM_ERROR:-2,Z_DATA_ERROR:-3,Z_BUF_ERROR:-5,Z_NO_COMPRESSION:0,Z_BEST_SPEED:1,Z_BEST_COMPRESSION:9,Z_DEFAULT_COMPRESSION:-1,Z_FILTERED:1,Z_HUFFMAN_ONLY:2,Z_RLE:3,Z_FIXED:4,Z_DEFAULT_STRATEGY:0,Z_BINARY:0,Z_TEXT:1,Z_UNKNOWN:2,Z_DEFLATED:8};function m2(){this.text=0,this.time=0,this.xflags=0,this.os=0,this.extra=null,this.extra_len=0,this.name="",this.comment="",this.hcrc=0,this.done=!1}var b2=m2,Ui=Un,Ba=lr,Fu=ai,Bt=_h,mo=no,D2=A0,x2=b2,vh=Object.prototype.toString;function oi(e){if(!(this instanceof oi))return new oi(e);this.options=Ba.assign({chunkSize:16384,windowBits:0,to:""},e||{});var n=this.options;n.raw&&n.windowBits>=0&&n.windowBits<16&&(n.windowBits=-n.windowBits,n.windowBits===0&&(n.windowBits=-15)),n.windowBits>=0&&n.windowBits<16&&!(e&&e.windowBits)&&(n.windowBits+=32),n.windowBits>15&&n.windowBits<48&&(n.windowBits&15||(n.windowBits|=15)),this.err=0,this.msg="",this.ended=!1,this.chunks=[],this.strm=new D2,this.strm.avail_out=0;var t=Ui.inflateInit2(this.strm,n.windowBits);if(t!==Bt.Z_OK)throw new Error(mo[t]);if(this.header=new x2,Ui.inflateGetHeader(this.strm,this.header),n.dictionary&&(typeof n.dictionary=="string"?n.dictionary=Fu.string2buf(n.dictionary):vh.call(n.dictionary)==="[object 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this.onEnd(s),this.ended=!0,!1;t.next_out&&(t.avail_out===0||s===Bt.Z_STREAM_END||t.avail_in===0&&(f===Bt.Z_FINISH||f===Bt.Z_SYNC_FLUSH))&&(this.options.to==="string"?(h=Fu.utf8border(t.output,t.next_out),v=t.next_out-h,d=Fu.buf2string(t.output,h),t.next_out=v,t.avail_out=a-v,v&&Ba.arraySet(t.output,t.output,h,v,0),this.onData(d)):this.onData(Ba.shrinkBuf(t.output,t.next_out))),t.avail_in===0&&t.avail_out===0&&(c=!0)}while((t.avail_in>0||t.avail_out===0)&&s!==Bt.Z_STREAM_END);return s===Bt.Z_STREAM_END&&(f=Bt.Z_FINISH),f===Bt.Z_FINISH?(s=Ui.inflateEnd(this.strm),this.onEnd(s),this.ended=!0,s===Bt.Z_OK):(f===Bt.Z_SYNC_FLUSH&&(this.onEnd(Bt.Z_OK),t.avail_out=0),!0)},oi.prototype.onData=function(e){this.chunks.push(e)},oi.prototype.onEnd=function(e){e===Bt.Z_OK&&(this.options.to==="string"?this.result=this.chunks.join(""):this.result=Ba.flattenChunks(this.chunks)),this.chunks=[],this.err=e,this.msg=this.strm.msg};function bo(e,n){var t=new oi(n);if(t.push(e,!0),t.err)throw t.msg||mo[t.err];return t.result}function y2(e,n){return n=n||{},n.raw=!0,bo(e,n)}Fa.Inflate=oi,Fa.inflate=bo,Fa.inflateRaw=y2,Fa.ungzip=bo;var E2=lr.assign,A2=da,F2=Fa,C2=_h,wh={};E2(wh,A2,F2,C2);var Cu=wh;async function Do(e){try{let n,t=0,a=0;const o=[];let s=0,f;do{const v=e.subarray(t);if(f=new Cu.Inflate,{strm:n}=f,f.push(v,Cu.Z_SYNC_FLUSH),f.err)throw new Error(f.msg);t+=n.next_in,o[a]=f.result,s+=o[a].length,a+=1}while(n.avail_in);const h=new Uint8Array(s);for(let v=0,d=0;v<o.length;v++)h.set(o[v],d),d+=o[v].length;return zr.from(h)}catch(n){throw/incorrect header check/.exec(`${n}`)?new Error("problem decompressing block: incorrect gzip header check"):n}}async function B2(e,n){try{let t;const{minv:a,maxv:o}=n;let s=a.blockPosition,f=a.dataPosition;const h=[],v=[],d=[];let c=0,D=0;do{const I=e.subarray(s-a.blockPosition),F=new Cu.Inflate;if({strm:t}=F,F.push(I,Cu.Z_SYNC_FLUSH),F.err)throw new Error(F.msg);const k=F.result;h.push(k);let L=k.length;v.push(s),d.push(f),h.length===1&&a.dataPosition&&(h[0]=h[0].subarray(a.dataPosition),L=h[0].length);const G=s;if(s+=t.next_in,f+=L,G>=o.blockPosition){h[D]=h[D].subarray(0,o.blockPosition===a.blockPosition?o.dataPosition-a.dataPosition+1:o.dataPosition+1),v.push(s),d.push(f),c+=h[D].length;break}c+=h[D].length,D++}while(t.avail_in);const y=new Uint8Array(c);for(let I=0,F=0;I<h.length;I++)y.set(h[I],F),F+=h[I].length;return{buffer:zr.from(y),cpositions:v,dpositions:d}}catch(t){throw/incorrect header check/.exec(`${t}`)?new Error("problem decompressing block: incorrect gzip header check"):t}}var S2=at,yn=null;try{yn=new WebAssembly.Instance(new WebAssembly.Module(new Uint8Array([0,97,115,109,1,0,0,0,1,13,2,96,0,1,127,96,4,127,127,127,127,1,127,3,7,6,0,1,1,1,1,1,6,6,1,127,1,65,0,11,7,50,6,3,109,117,108,0,1,5,100,105,118,95,115,0,2,5,100,105,118,95,117,0,3,5,114,101,109,95,115,0,4,5,114,101,109,95,117,0,5,8,103,101,116,95,104,105,103,104,0,0,10,191,1,6,4,0,35,0,11,36,1,1,126,32,0,173,32,1,173,66,32,134,132,32,2,173,32,3,173,66,32,134,132,126,34,4,66,32,135,167,36,0,32,4,167,11,36,1,1,126,32,0,173,32,1,173,66,32,134,132,32,2,173,32,3,173,66,32,134,132,127,34,4,66,32,135,167,36,0,32,4,167,11,36,1,1,126,32,0,173,32,1,173,66,32,134,132,32,2,173,32,3,173,66,32,134,132,128,34,4,66,32,135,167,36,0,32,4,167,11,36,1,1,126,32,0,173,32,1,173,66,32,134,132,32,2,173,32,3,173,66,32,134,132,129,34,4,66,32,135,167,36,0,32,4,167,11,36,1,1,126,32,0,173,32,1,173,66,32,134,132,32,2,173,32,3,173,66,32,134,132,130,34,4,66,32,135,167,36,0,32,4,167,11])),{}).exports}catch{}function at(e,n,t){this.low=e|0,this.high=n|0,this.unsigned=!!t}at.prototype.__isLong__,Object.defineProperty(at.prototype,"__isLong__",{value:!0});function en(e){return(e&&e.__isLong__)===!0}at.isLong=en;var mh={},bh={};function fi(e,n){var t,a,o;return n?(e>>>=0,(o=0<=e&&e<256)&&(a=bh[e],a)?a:(t=ut(e,(e|0)<0?-1:0,!0),o&&(bh[e]=t),t)):(e|=0,(o=-128<=e&&e<128)&&(a=mh[e],a)?a:(t=ut(e,e<0?-1:0,!1),o&&(mh[e]=t),t))}at.fromInt=fi;function En(e,n){if(isNaN(e))return n?li:An;if(n){if(e<0)return li;if(e>=xh)return Ch}else{if(e<=-yh)return tn;if(e+1>=yh)return Fh}return e<0?En(-e,n).neg():ut(e%Wi|0,e/Wi|0,n)}at.fromNumber=En;function ut(e,n,t){return new at(e,n,t)}at.fromBits=ut;var Bu=Math.pow;function xo(e,n,t){if(e.length===0)throw Error("empty string");if(e==="NaN"||e==="Infinity"||e==="+Infinity"||e==="-Infinity")return An;if(typeof n=="number"?(t=n,n=!1):n=!!n,t=t||10,t<2||36<t)throw RangeError("radix");var a;if((a=e.indexOf("-"))>0)throw Error("interior hyphen");if(a===0)return xo(e.substring(1),n,t).neg();for(var o=En(Bu(t,8)),s=An,f=0;f<e.length;f+=8){var h=Math.min(8,e.length-f),v=parseInt(e.substring(f,f+h),t);if(h<8){var d=En(Bu(t,h));s=s.mul(d).add(En(v))}else s=s.mul(o),s=s.add(En(v))}return s.unsigned=n,s}at.fromString=xo;function Wn(e,n){return typeof e=="number"?En(e,n):typeof e=="string"?xo(e,n):ut(e.low,e.high,typeof n=="boolean"?n:e.unsigned)}at.fromValue=Wn;var Dh=65536,I2=1<<24,Wi=Dh*Dh,xh=Wi*Wi,yh=xh/2,Eh=fi(I2),An=fi(0);at.ZERO=An;var li=fi(0,!0);at.UZERO=li;var qi=fi(1);at.ONE=qi;var Ah=fi(1,!0);at.UONE=Ah;var yo=fi(-1);at.NEG_ONE=yo;var Fh=ut(-1,2147483647,!1);at.MAX_VALUE=Fh;var Ch=ut(-1,-1,!0);at.MAX_UNSIGNED_VALUE=Ch;var tn=ut(0,-2147483648,!1);at.MIN_VALUE=tn;var re=at.prototype;re.toInt=function(){return this.unsigned?this.low>>>0:this.low},re.toNumber=function(){return this.unsigned?(this.high>>>0)*Wi+(this.low>>>0):this.high*Wi+(this.low>>>0)},re.toString=function(n){if(n=n||10,n<2||36<n)throw RangeError("radix");if(this.isZero())return"0";if(this.isNegative())if(this.eq(tn)){var t=En(n),a=this.div(t),o=a.mul(t).sub(this);return a.toString(n)+o.toInt().toString(n)}else return"-"+this.neg().toString(n);for(var s=En(Bu(n,6),this.unsigned),f=this,h="";;){var v=f.div(s),d=f.sub(v.mul(s)).toInt()>>>0,c=d.toString(n);if(f=v,f.isZero())return c+h;for(;c.length<6;)c="0"+c;h=""+c+h}},re.getHighBits=function(){return this.high},re.getHighBitsUnsigned=function(){return this.high>>>0},re.getLowBits=function(){return this.low},re.getLowBitsUnsigned=function(){return this.low>>>0},re.getNumBitsAbs=function(){if(this.isNegative())return this.eq(tn)?64:this.neg().getNumBitsAbs();for(var n=this.high!=0?this.high:this.low,t=31;t>0&&!(n&1<<t);t--);return this.high!=0?t+33:t+1},re.isZero=function(){return this.high===0&&this.low===0},re.eqz=re.isZero,re.isNegative=function(){return!this.unsigned&&this.high<0},re.isPositive=function(){return this.unsigned||this.high>=0},re.isOdd=function(){return(this.low&1)===1},re.isEven=function(){return(this.low&1)===0},re.equals=function(n){return en(n)||(n=Wn(n)),this.unsigned!==n.unsigned&&this.high>>>31===1&&n.high>>>31===1?!1:this.high===n.high&&this.low===n.low},re.eq=re.equals,re.notEquals=function(n){return!this.eq(n)},re.neq=re.notEquals,re.ne=re.notEquals,re.lessThan=function(n){return this.comp(n)<0},re.lt=re.lessThan,re.lessThanOrEqual=function(n){return this.comp(n)<=0},re.lte=re.lessThanOrEqual,re.le=re.lessThanOrEqual,re.greaterThan=function(n){return this.comp(n)>0},re.gt=re.greaterThan,re.greaterThanOrEqual=function(n){return this.comp(n)>=0},re.gte=re.greaterThanOrEqual,re.ge=re.greaterThanOrEqual,re.compare=function(n){if(en(n)||(n=Wn(n)),this.eq(n))return 0;var t=this.isNegative(),a=n.isNegative();return t&&!a?-1:!t&&a?1:this.unsigned?n.high>>>0>this.high>>>0||n.high===this.high&&n.low>>>0>this.low>>>0?-1:1:this.sub(n).isNegative()?-1:1},re.comp=re.compare,re.negate=function(){return!this.unsigned&&this.eq(tn)?tn:this.not().add(qi)},re.neg=re.negate,re.add=function(n){en(n)||(n=Wn(n));var t=this.high>>>16,a=this.high&65535,o=this.low>>>16,s=this.low&65535,f=n.high>>>16,h=n.high&65535,v=n.low>>>16,d=n.low&65535,c=0,D=0,y=0,m=0;return m+=s+d,y+=m>>>16,m&=65535,y+=o+v,D+=y>>>16,y&=65535,D+=a+h,c+=D>>>16,D&=65535,c+=t+f,c&=65535,ut(y<<16|m,c<<16|D,this.unsigned)},re.subtract=function(n){return en(n)||(n=Wn(n)),this.add(n.neg())},re.sub=re.subtract,re.multiply=function(n){if(this.isZero())return An;if(en(n)||(n=Wn(n)),yn){var t=yn.mul(this.low,this.high,n.low,n.high);return ut(t,yn.get_high(),this.unsigned)}if(n.isZero())return An;if(this.eq(tn))return n.isOdd()?tn:An;if(n.eq(tn))return this.isOdd()?tn:An;if(this.isNegative())return n.isNegative()?this.neg().mul(n.neg()):this.neg().mul(n).neg();if(n.isNegative())return this.mul(n.neg()).neg();if(this.lt(Eh)&&n.lt(Eh))return En(this.toNumber()*n.toNumber(),this.unsigned);var a=this.high>>>16,o=this.high&65535,s=this.low>>>16,f=this.low&65535,h=n.high>>>16,v=n.high&65535,d=n.low>>>16,c=n.low&65535,D=0,y=0,m=0,I=0;return I+=f*c,m+=I>>>16,I&=65535,m+=s*c,y+=m>>>16,m&=65535,m+=f*d,y+=m>>>16,m&=65535,y+=o*c,D+=y>>>16,y&=65535,y+=s*d,D+=y>>>16,y&=65535,y+=f*v,D+=y>>>16,y&=65535,D+=a*c+o*d+s*v+f*h,D&=65535,ut(m<<16|I,D<<16|y,this.unsigned)},re.mul=re.multiply,re.divide=function(n){if(en(n)||(n=Wn(n)),n.isZero())throw Error("division by zero");if(yn){if(!this.unsigned&&this.high===-2147483648&&n.low===-1&&n.high===-1)return this;var t=(this.unsigned?yn.div_u:yn.div_s)(this.low,this.high,n.low,n.high);return ut(t,yn.get_high(),this.unsigned)}if(this.isZero())return this.unsigned?li:An;var a,o,s;if(this.unsigned){if(n.unsigned||(n=n.toUnsigned()),n.gt(this))return li;if(n.gt(this.shru(1)))return Ah;s=li}else{if(this.eq(tn)){if(n.eq(qi)||n.eq(yo))return tn;if(n.eq(tn))return qi;var f=this.shr(1);return a=f.div(n).shl(1),a.eq(An)?n.isNegative()?qi:yo:(o=this.sub(n.mul(a)),s=a.add(o.div(n)),s)}else if(n.eq(tn))return this.unsigned?li:An;if(this.isNegative())return n.isNegative()?this.neg().div(n.neg()):this.neg().div(n).neg();if(n.isNegative())return this.div(n.neg()).neg();s=An}for(o=this;o.gte(n);){a=Math.max(1,Math.floor(o.toNumber()/n.toNumber()));for(var h=Math.ceil(Math.log(a)/Math.LN2),v=h<=48?1:Bu(2,h-48),d=En(a),c=d.mul(n);c.isNegative()||c.gt(o);)a-=v,d=En(a,this.unsigned),c=d.mul(n);d.isZero()&&(d=qi),s=s.add(d),o=o.sub(c)}return s},re.div=re.divide,re.modulo=function(n){if(en(n)||(n=Wn(n)),yn){var t=(this.unsigned?yn.rem_u:yn.rem_s)(this.low,this.high,n.low,n.high);return ut(t,yn.get_high(),this.unsigned)}return this.sub(this.div(n).mul(n))},re.mod=re.modulo,re.rem=re.modulo,re.not=function(){return ut(~this.low,~this.high,this.unsigned)},re.and=function(n){return en(n)||(n=Wn(n)),ut(this.low&n.low,this.high&n.high,this.unsigned)},re.or=function(n){return en(n)||(n=Wn(n)),ut(this.low|n.low,this.high|n.high,this.unsigned)},re.xor=function(n){return en(n)||(n=Wn(n)),ut(this.low^n.low,this.high^n.high,this.unsigned)},re.shiftLeft=function(n){return en(n)&&(n=n.toInt()),(n&=63)===0?this:n<32?ut(this.low<<n,this.high<<n|this.low>>>32-n,this.unsigned):ut(0,this.low<<n-32,this.unsigned)},re.shl=re.shiftLeft,re.shiftRight=function(n){return en(n)&&(n=n.toInt()),(n&=63)===0?this:n<32?ut(this.low>>>n|this.high<<32-n,this.high>>n,this.unsigned):ut(this.high>>n-32,this.high>=0?0:-1,this.unsigned)},re.shr=re.shiftRight,re.shiftRightUnsigned=function(n){if(en(n)&&(n=n.toInt()),n&=63,n===0)return this;var t=this.high;if(n<32){var a=this.low;return ut(a>>>n|t<<32-n,t>>>n,this.unsigned)}else return n===32?ut(t,0,this.unsigned):ut(t>>>n-32,0,this.unsigned)},re.shru=re.shiftRightUnsigned,re.shr_u=re.shiftRightUnsigned,re.toSigned=function(){return this.unsigned?ut(this.low,this.high,!1):this},re.toUnsigned=function(){return this.unsigned?this:ut(this.low,this.high,!0)},re.toBytes=function(n){return n?this.toBytesLE():this.toBytesBE()},re.toBytesLE=function(){var n=this.high,t=this.low;return[t&255,t>>>8&255,t>>>16&255,t>>>24,n&255,n>>>8&255,n>>>16&255,n>>>24]},re.toBytesBE=function(){var n=this.high,t=this.low;return[n>>>24,n>>>16&255,n>>>8&255,n&255,t>>>24,t>>>16&255,t>>>8&255,t&255]},at.fromBytes=function(n,t,a){return a?at.fromBytesLE(n,t):at.fromBytesBE(n,t)},at.fromBytesLE=function(n,t){return new at(n[0]|n[1]<<8|n[2]<<16|n[3]<<24,n[4]|n[5]<<8|n[6]<<16|n[7]<<24,t)},at.fromBytesBE=function(n,t){return new at(n[4]<<24|n[5]<<16|n[6]<<8|n[7],n[0]<<24|n[1]<<16|n[2]<<8|n[3],t)};var Bh=wn(S2);function Sh(e){if(e.greaterThan(Number.MAX_SAFE_INTEGER)||e.lessThan(Number.MIN_SAFE_INTEGER))throw new Error("integer overflow");return e.toNumber()}let T2=class extends Error{};function Sa(e){if(e&&e.aborted){if(typeof DOMException<"u")throw new DOMException("aborted","AbortError");{const n=new T2("aborted");throw n.code="ERR_ABORTED",n}}}function k2(e,n){return n.minv.blockPosition-e.maxv.blockPosition<65e3&&n.maxv.blockPosition-e.minv.blockPosition<5e6}function Ih(e,n){const t=[];let a=null;return e.length===0?e:(e.sort(function(o,s){const f=o.minv.blockPosition-s.minv.blockPosition;return f!==0?f:o.minv.dataPosition-s.minv.dataPosition}),e.forEach(o=>{(!n||o.maxv.compareTo(n)>0)&&(a===null?(t.push(o),a=o):k2(a,o)?o.maxv.compareTo(a.maxv)>0&&(a.maxv=o.maxv):(t.push(o),a=o))}),t)}class Eo{constructor(n,t){this.blockPosition=n,this.dataPosition=t}toString(){return`${this.blockPosition}:${this.dataPosition}`}compareTo(n){return this.blockPosition-n.blockPosition||this.dataPosition-n.dataPosition}}function Gi(e,n=0,t=!1){if(t)throw new Error("big-endian virtual file offsets not implemented");return new Eo(e[n+7]*1099511627776+e[n+6]*4294967296+e[n+5]*16777216+e[n+4]*65536+e[n+3]*256+e[n+2],e[n+1]<<8|e[n])}class Su{constructor(n,t,a,o=void 0){this.minv=n,this.maxv=t,this.bin=a,this._fetchedSize=o}toUniqueString(){return`${this.minv}..${this.maxv} (bin ${this.bin}, fetchedSize ${this.fetchedSize()})`}toString(){return this.toUniqueString()}compareTo(n){return this.minv.compareTo(n.minv)||this.maxv.compareTo(n.maxv)||this.bin-n.bin}fetchedSize(){return this._fetchedSize!==void 0?this._fetchedSize:this.maxv.blockPosition+65536-this.minv.blockPosition}}class Th{constructor({filehandle:n,renameRefSeqs:t=a=>a}){this.filehandle=n,this.renameRefSeq=t}async getMetadata(n={}){const{indices:t,...a}=await this.parse(n);return a}_findFirstData(n,t){return n?n.compareTo(t)>0?t:n:t}async parse(n={}){return this.parseP||(this.parseP=this._parse(n).catch(t=>{throw this.parseP=void 0,t})),this.parseP}async hasRefSeq(n,t={}){var a;return!!(!((a=(await this.parse(t)).indices[n])===null||a===void 0)&&a.binIndex)}}const R2=21578324,kh=14;function L2(e,n){return e+=1,n-=1,[[0,0],[1+(e>>26),1+(n>>26)],[9+(e>>23),9+(n>>23)],[73+(e>>20),73+(n>>20)],[585+(e>>17),585+(n>>17)],[4681+(e>>14),4681+(n>>14)]]}class Ia extends Th{async lineCount(n,t={}){const a=await this.parse(t),o=a.refNameToId[n];if(o===void 0||!a.indices[o])return-1;const{stats:f}=a.indices[o];return f?f.lineCount:-1}async _parse(n={}){const t=await this.filehandle.readFile(n),a=await Do(t);if(Sa(n.signal),a.readUInt32LE(0)!==R2)throw new Error("Not a TBI file");const o=a.readInt32LE(4),s=a.readInt32LE(8),f=s&65536?"zero-based-half-open":"1-based-closed",v={0:"generic",1:"SAM",2:"VCF"}[s&15];if(!v)throw new Error(`invalid Tabix preset format flags ${s}`);const d={ref:a.readInt32LE(12),start:a.readInt32LE(16),end:a.readInt32LE(20)},c=a.readInt32LE(24),D=5,y=((1<<(D+1)*3)-1)/7,m=2**(14+D*3),I=c?String.fromCharCode(c):null,F=a.readInt32LE(28),k=a.readInt32LE(32),{refNameToId:L,refIdToName:G}=this._parseNameBytes(a.slice(36,36+k));let P=36+k,T;return{indices:new Array(o).fill(0).map(()=>{const q=a.readInt32LE(P);P+=4;const N={};let C;for(let W=0;W<q;W+=1){const V=a.readUInt32LE(P);if(P+=4,V>y+1)throw new Error("tabix index contains too many bins, please use a CSI index");if(V===y+1){const te=a.readInt32LE(P);P+=4,te===2&&(C=this.parsePseudoBin(a,P)),P+=16*te}else{const te=a.readInt32LE(P);P+=4;const ie=new Array(te);for(let le=0;le<te;le+=1){const Fe=Gi(a,P),ae=Gi(a,P+8);P+=16,T=this._findFirstData(T,Fe),ie[le]=new Su(Fe,ae,V)}N[V]=ie}}const S=a.readInt32LE(P);P+=4;const O=new Array(S);for(let W=0;W<S;W+=1)O[W]=Gi(a,P),P+=8,T=this._findFirstData(T,O[W]);return{binIndex:N,linearIndex:O,stats:C}}),metaChar:I,maxBinNumber:y,maxRefLength:m,skipLines:F,firstDataLine:T,columnNumbers:d,coordinateType:f,format:v,refIdToName:G,refNameToId:L,maxBlockSize:65536}}parsePseudoBin(n,t){return{lineCount:Sh(Bh.fromBytesLE(n.slice(t+16,t+24),!0))}}_parseNameBytes(n){let t=0,a=0;const o=[],s={};for(let f=0;f<n.length;f+=1)if(!n[f]){if(a<f){let h=n.toString("utf8",a,f);h=this.renameRefSeq(h),o[t]=h,s[h]=t}a=f+1,t+=1}return{refNameToId:s,refIdToName:o}}async blocksForRange(n,t,a,o={}){t<0&&(t=0);const s=await this.parse(o),f=s.refNameToId[n];if(f===void 0)return[];const h=s.indices[f];if(!h)return[];(h.linearIndex.length?h.linearIndex[t>>kh>=h.linearIndex.length?h.linearIndex.length-1:t>>kh]:new Eo(0,0))||console.warn("querying outside of possible tabix range");const d=L2(t,a),c=[];for(const[F,k]of d)for(let L=F;L<=k;L++)if(h.binIndex[L])for(const G of h.binIndex[L])c.push(new Su(G.minv,G.maxv,L));const D=h.linearIndex.length;let y=null;const m=Math.min(t>>14,D-1),I=Math.min(a>>14,D-1);for(let F=m;F<=I;++F){const k=h.linearIndex[F];k&&(!y||k.compareTo(y)<0)&&(y=k)}return Ih(c,y)}}const N2=21582659,O2=38359875;function M2(e,n){return e*2**n}function Rh(e,n){return Math.floor(e/2**n)}class Ao extends Th{constructor(n){super(n),this.maxBinNumber=0,this.depth=0,this.minShift=0}async lineCount(n,t={}){const a=await this.parse(t),o=a.refNameToId[n];if(o===void 0||!a.indices[o])return-1;const{stats:f}=a.indices[o];return f?f.lineCount:-1}indexCov(){throw new Error("CSI indexes do not support indexcov")}parseAuxData(n,t){const a=n.readInt32LE(t),o=a&65536?"zero-based-half-open":"1-based-closed",s={0:"generic",1:"SAM",2:"VCF"}[a&15];if(!s)throw new Error(`invalid Tabix preset format flags ${a}`);const f={ref:n.readInt32LE(t+4),start:n.readInt32LE(t+8),end:n.readInt32LE(t+12)},h=n.readInt32LE(t+16),v=h?String.fromCharCode(h):null,d=n.readInt32LE(t+20),c=n.readInt32LE(t+24),{refIdToName:D,refNameToId:y}=this._parseNameBytes(n.slice(t+28,t+28+c));return{refIdToName:D,refNameToId:y,skipLines:d,metaChar:v,columnNumbers:f,format:s,coordinateType:o}}_parseNameBytes(n){let t=0,a=0;const o=[],s={};for(let f=0;f<n.length;f+=1)if(!n[f]){if(a<f){let h=n.toString("utf8",a,f);h=this.renameRefSeq(h),o[t]=h,s[h]=t}a=f+1,t+=1}return{refNameToId:s,refIdToName:o}}async _parse(n={}){const t=await Do(await this.filehandle.readFile(n));let a;if(t.readUInt32LE(0)===N2)a=1;else if(t.readUInt32LE(0)===O2)a=2;else throw new Error("Not a CSI file");this.minShift=t.readInt32LE(4),this.depth=t.readInt32LE(8),this.maxBinNumber=((1<<(this.depth+1)*3)-1)/7;const o=2**(this.minShift+this.depth*3),s=t.readInt32LE(12),f=s&&s>=30?this.parseAuxData(t,16):{refIdToName:[],refNameToId:{},metaChar:null,columnNumbers:{ref:0,start:1,end:2},coordinateType:"zero-based-half-open",format:"generic"},h=t.readInt32LE(16+s);let v,d=16+s+4;const c=new Array(h).fill(0).map(()=>{const D=t.readInt32LE(d);d+=4;const y={};let m;for(let I=0;I<D;I+=1){const F=t.readUInt32LE(d);if(F>this.maxBinNumber)m=this.parsePseudoBin(t,d+4),d+=48;else{const k=Gi(t,d+4);v=this._findFirstData(v,k);const L=t.readInt32LE(d+12);d+=16;const G=new Array(L);for(let P=0;P<L;P+=1){const T=Gi(t,d),$=Gi(t,d+8);d+=16,G[P]=new Su(T,$,F)}y[F]=G}}return{binIndex:y,stats:m}});return{...f,csi:!0,refCount:h,maxBlockSize:65536,firstDataLine:v,csiVersion:a,indices:c,depth:this.depth,maxBinNumber:this.maxBinNumber,maxRefLength:o}}parsePseudoBin(n,t){return{lineCount:Sh(Bh.fromBytesLE(n.slice(t+28,t+36),!0))}}async blocksForRange(n,t,a,o={}){t<0&&(t=0);const s=await this.parse(o),f=s.refNameToId[n];if(f===void 0)return[];const h=s.indices[f];if(!h)return[];const v=this.reg2bins(t,a),d=[];for(const[c,D]of v)for(let y=c;y<=D;y++)if(h.binIndex[y])for(const m of h.binIndex[y])d.push(new Su(m.minv,m.maxv,y));return Ih(d,new Eo(0,0))}reg2bins(n,t){n-=1,n<1&&(n=1),t>2**50&&(t=2**34),t-=1;let a=0,o=0,s=this.minShift+this.depth*3;const f=[];for(;a<=this.depth;s-=3,o+=M2(1,a*3),a+=1){const h=o+Rh(n,s),v=o+Rh(t,s);if(v-h+f.length>this.maxBinNumber)throw new Error(`query ${n}-${t} is too large for current binning scheme (shift ${this.minShift}, depth ${this.depth}), try a smaller query or a coarser index binning scheme`);f.push([h,v])}return f}}function P2(e){return/^[\u0000-\u007F]*$/.test(e)}const Hi=typeof TextDecoder<"u"?new TextDecoder("utf8"):void 0;class Lh{constructor({path:n,filehandle:t,url:a,tbiPath:o,tbiUrl:s,tbiFilehandle:f,csiPath:h,csiUrl:v,csiFilehandle:d,renameRefSeqs:c=y=>y,chunkCacheSize:D=5*2**20}){if(t)this.filehandle=t;else if(n)this.filehandle=new hu(n);else if(a)this.filehandle=new Tr(a);else throw new TypeError("must provide either filehandle or path");if(f)this.index=new Ia({filehandle:f,renameRefSeqs:c});else if(d)this.index=new Ao({filehandle:d,renameRefSeqs:c});else if(o)this.index=new Ia({filehandle:new hu(o),renameRefSeqs:c});else if(h)this.index=new Ao({filehandle:new hu(h),renameRefSeqs:c});else if(n)this.index=new Ia({filehandle:new hu(`${n}.tbi`),renameRefSeqs:c});else if(v)this.index=new Ao({filehandle:new Tr(v)});else if(s)this.index=new Ia({filehandle:new Tr(s)});else if(a)this.index=new Ia({filehandle:new Tr(`${a}.tbi`)});else throw new TypeError("must provide one of tbiFilehandle, tbiPath, csiFilehandle, csiPath, tbiUrl, csiUrl");this.renameRefSeq=c,this.chunkCache=new Ap({cache:new Pl({maxSize:Math.floor(D/65536)}),fill:(y,m)=>this.readChunk(y,{signal:m})})}async getLines(n,t,a,o){var s,f;let h,v={},d;typeof o=="function"?d=o:(v=o,d=o.lineCallback,h=o.signal);const c=await this.index.getMetadata(v);Sa(h);const D=t??0,y=a??c.maxRefLength;if(!(D<=y))throw new TypeError("invalid start and end coordinates. start must be less than or equal to end");if(D===y)return;const m=await this.index.blocksForRange(n,D,y,v);Sa(h);for(const I of m){const{buffer:F,cpositions:k,dpositions:L}=await this.chunkCache.get(I.toString(),I,h);Sa(h);let G=0,P=0;const T=(s=Hi==null?void 0:Hi.decode(F))!==null&&s!==void 0?s:F.toString(),$=F.length<5e8&&P2(T);for(;G<T.length;){let q,N;if($){if(N=T.indexOf(`
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n.wsize=0,n.whave=0,n.wnext=0,Gc(e)},Zc=(e,n)=>{let t;if(pi(e))return Fn;const a=e.state;return n<0?(t=0,n=-n):(t=(n>>4)+5,n<48&&(n&=15)),n&&(n<8||n>15)?Fn:(a.window!==null&&a.wbits!==n&&(a.window=null),a.wrap=t,a.wbits=n,Hc(e))},Xc=(e,n)=>{if(!e)return Fn;const t=new Ow;e.state=t,t.strm=e,t.window=null,t.mode=Pu;const a=Zc(e,n);return a!==gi&&(e.state=null),a},Mw=e=>Xc(e,Nw);let Vc=!0,jo,zo;const Pw=e=>{if(Vc){jo=new Int32Array(512),zo=new Int32Array(32);let n=0;for(;n<144;)e.lens[n++]=8;for(;n<256;)e.lens[n++]=9;for(;n<280;)e.lens[n++]=7;for(;n<288;)e.lens[n++]=8;for(Ua(dc,e.lens,0,288,jo,0,e.work,{bits:9}),n=0;n<32;)e.lens[n++]=5;Ua(gc,e.lens,0,32,zo,0,e.work,{bits:5}),Vc=!1}e.lencode=jo,e.lenbits=9,e.distcode=zo,e.distbits=5},Kc=(e,n,t,a)=>{let o;const s=e.state;return s.window===null&&(s.wsize=1<<s.wbits,s.wnext=0,s.whave=0,s.window=new Uint8Array(s.wsize)),a>=s.wsize?(s.window.set(n.subarray(t-s.wsize,t),0),s.wnext=0,s.whave=s.wsize):(o=s.wsize-s.wnext,o>a&&(o=a),s.window.set(n.subarray(t-a,t-a+o),s.wnext),a-=o,a?(s.window.set(n.subarray(t-a,t),0),s.wnext=a,s.whave=s.wsize):(s.wnext+=o,s.wnext===s.wsize&&(s.wnext=0),s.whave<s.wsize&&(s.whave+=o))),0},$w=(e,n)=>{let t,a,o,s,f,h,v,d,c,D,y,m,I,F,k=0,L,G,P,T,$,q,N,C;const S=new Uint8Array(4);let O,W;const V=new Uint8Array([16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15]);if(pi(e)||!e.output||!e.input&&e.avail_in!==0)return Fn;t=e.state,t.mode===dr&&(t.mode=Yo),f=e.next_out,o=e.output,v=e.avail_out,s=e.next_in,a=e.input,h=e.avail_in,d=t.hold,c=t.bits,D=h,y=v,C=gi;e:for(;;)switch(t.mode){case Pu:if(t.wrap===0){t.mode=Yo;break}for(;c<16;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(t.wrap&2&&d===35615){t.wbits===0&&(t.wbits=15),t.check=0,S[0]=d&255,S[1]=d>>>8&255,t.check=ir(t.check,S,2,0),d=0,c=0,t.mode=mc;break}if(t.head&&(t.head.done=!1),!(t.wrap&1)||(((d&255)<<8)+(d>>8))%31){e.msg="incorrect header check",t.mode=_t;break}if((d&15)!==wc){e.msg="unknown compression method",t.mode=_t;break}if(d>>>=4,c-=4,N=(d&15)+8,t.wbits===0&&(t.wbits=N),N>15||N>t.wbits){e.msg="invalid window size",t.mode=_t;break}t.dmax=1<<t.wbits,t.flags=0,e.adler=t.check=1,t.mode=d&512?Cc:dr,d=0,c=0;break;case mc:for(;c<16;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(t.flags=d,(t.flags&255)!==wc){e.msg="unknown compression method",t.mode=_t;break}if(t.flags&57344){e.msg="unknown header flags set",t.mode=_t;break}t.head&&(t.head.text=d>>8&1),t.flags&512&&t.wrap&4&&(S[0]=d&255,S[1]=d>>>8&255,t.check=ir(t.check,S,2,0)),d=0,c=0,t.mode=bc;case bc:for(;c<32;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}t.head&&(t.head.time=d),t.flags&512&&t.wrap&4&&(S[0]=d&255,S[1]=d>>>8&255,S[2]=d>>>16&255,S[3]=d>>>24&255,t.check=ir(t.check,S,4,0)),d=0,c=0,t.mode=Dc;case Dc:for(;c<16;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}t.head&&(t.head.xflags=d&255,t.head.os=d>>8),t.flags&512&&t.wrap&4&&(S[0]=d&255,S[1]=d>>>8&255,t.check=ir(t.check,S,2,0)),d=0,c=0,t.mode=xc;case xc:if(t.flags&1024){for(;c<16;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}t.length=d,t.head&&(t.head.extra_len=d),t.flags&512&&t.wrap&4&&(S[0]=d&255,S[1]=d>>>8&255,t.check=ir(t.check,S,2,0)),d=0,c=0}else t.head&&(t.head.extra=null);t.mode=yc;case yc:if(t.flags&1024&&(m=t.length,m>h&&(m=h),m&&(t.head&&(N=t.head.extra_len-t.length,t.head.extra||(t.head.extra=new Uint8Array(t.head.extra_len)),t.head.extra.set(a.subarray(s,s+m),N)),t.flags&512&&t.wrap&4&&(t.check=ir(t.check,a,m,s)),h-=m,s+=m,t.length-=m),t.length))break e;t.length=0,t.mode=Ec;case Ec:if(t.flags&2048){if(h===0)break e;m=0;do N=a[s+m++],t.head&&N&&t.length<65536&&(t.head.name+=String.fromCharCode(N));while(N&&m<h);if(t.flags&512&&t.wrap&4&&(t.check=ir(t.check,a,m,s)),h-=m,s+=m,N)break e}else t.head&&(t.head.name=null);t.length=0,t.mode=Ac;case Ac:if(t.flags&4096){if(h===0)break e;m=0;do N=a[s+m++],t.head&&N&&t.length<65536&&(t.head.comment+=String.fromCharCode(N));while(N&&m<h);if(t.flags&512&&t.wrap&4&&(t.check=ir(t.check,a,m,s)),h-=m,s+=m,N)break e}else t.head&&(t.head.comment=null);t.mode=Fc;case Fc:if(t.flags&512){for(;c<16;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(t.wrap&4&&d!==(t.check&65535)){e.msg="header crc mismatch",t.mode=_t;break}d=0,c=0}t.head&&(t.head.hcrc=t.flags>>9&1,t.head.done=!0),e.adler=t.check=0,t.mode=dr;break;case Cc:for(;c<32;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}e.adler=t.check=qc(d),d=0,c=0,t.mode=$u;case $u:if(t.havedict===0)return e.next_out=f,e.avail_out=v,e.next_in=s,e.avail_in=h,t.hold=d,t.bits=c,Tw;e.adler=t.check=1,t.mode=dr;case dr:if(n===Sw||n===Mu)break e;case Yo:if(t.last){d>>>=c&7,c-=c&7,t.mode=Jo;break}for(;c<3;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}switch(t.last=d&1,d>>>=1,c-=1,d&3){case 0:t.mode=Bc;break;case 1:if(Pw(t),t.mode=Uu,n===Mu){d>>>=2,c-=2;break e}break;case 2:t.mode=Ic;break;case 3:e.msg="invalid block type",t.mode=_t}d>>>=2,c-=2;break;case Bc:for(d>>>=c&7,c-=c&7;c<32;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if((d&65535)!==(d>>>16^65535)){e.msg="invalid stored block lengths",t.mode=_t;break}if(t.length=d&65535,d=0,c=0,t.mode=Qo,n===Mu)break e;case Qo:t.mode=Sc;case Sc:if(m=t.length,m){if(m>h&&(m=h),m>v&&(m=v),m===0)break e;o.set(a.subarray(s,s+m),f),h-=m,s+=m,v-=m,f+=m,t.length-=m;break}t.mode=dr;break;case Ic:for(;c<14;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(t.nlen=(d&31)+257,d>>>=5,c-=5,t.ndist=(d&31)+1,d>>>=5,c-=5,t.ncode=(d&15)+4,d>>>=4,c-=4,t.nlen>286||t.ndist>30){e.msg="too many length or distance symbols",t.mode=_t;break}t.have=0,t.mode=Tc;case Tc:for(;t.have<t.ncode;){for(;c<3;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}t.lens[V[t.have++]]=d&7,d>>>=3,c-=3}for(;t.have<19;)t.lens[V[t.have++]]=0;if(t.lencode=t.lendyn,t.lenbits=7,O={bits:t.lenbits},C=Ua(Bw,t.lens,0,19,t.lencode,0,t.work,O),t.lenbits=O.bits,C){e.msg="invalid code lengths set",t.mode=_t;break}t.have=0,t.mode=kc;case kc:for(;t.have<t.nlen+t.ndist;){for(;k=t.lencode[d&(1<<t.lenbits)-1],L=k>>>24,G=k>>>16&255,P=k&65535,!(L<=c);){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(P<16)d>>>=L,c-=L,t.lens[t.have++]=P;else{if(P===16){for(W=L+2;c<W;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(d>>>=L,c-=L,t.have===0){e.msg="invalid bit length repeat",t.mode=_t;break}N=t.lens[t.have-1],m=3+(d&3),d>>>=2,c-=2}else if(P===17){for(W=L+3;c<W;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}d>>>=L,c-=L,N=0,m=3+(d&7),d>>>=3,c-=3}else{for(W=L+7;c<W;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}d>>>=L,c-=L,N=0,m=11+(d&127),d>>>=7,c-=7}if(t.have+m>t.nlen+t.ndist){e.msg="invalid bit length repeat",t.mode=_t;break}for(;m--;)t.lens[t.have++]=N}}if(t.mode===_t)break;if(t.lens[256]===0){e.msg="invalid code -- missing end-of-block",t.mode=_t;break}if(t.lenbits=9,O={bits:t.lenbits},C=Ua(dc,t.lens,0,t.nlen,t.lencode,0,t.work,O),t.lenbits=O.bits,C){e.msg="invalid literal/lengths set",t.mode=_t;break}if(t.distbits=6,t.distcode=t.distdyn,O={bits:t.distbits},C=Ua(gc,t.lens,t.nlen,t.ndist,t.distcode,0,t.work,O),t.distbits=O.bits,C){e.msg="invalid distances set",t.mode=_t;break}if(t.mode=Uu,n===Mu)break e;case Uu:t.mode=Wu;case Wu:if(h>=6&&v>=258){e.next_out=f,e.avail_out=v,e.next_in=s,e.avail_in=h,t.hold=d,t.bits=c,yw(e,y),f=e.next_out,o=e.output,v=e.avail_out,s=e.next_in,a=e.input,h=e.avail_in,d=t.hold,c=t.bits,t.mode===dr&&(t.back=-1);break}for(t.back=0;k=t.lencode[d&(1<<t.lenbits)-1],L=k>>>24,G=k>>>16&255,P=k&65535,!(L<=c);){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(G&&!(G&240)){for(T=L,$=G,q=P;k=t.lencode[q+((d&(1<<T+$)-1)>>T)],L=k>>>24,G=k>>>16&255,P=k&65535,!(T+L<=c);){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}d>>>=T,c-=T,t.back+=T}if(d>>>=L,c-=L,t.back+=L,t.length=P,G===0){t.mode=Mc;break}if(G&32){t.back=-1,t.mode=dr;break}if(G&64){e.msg="invalid literal/length code",t.mode=_t;break}t.extra=G&15,t.mode=Rc;case Rc:if(t.extra){for(W=t.extra;c<W;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}t.length+=d&(1<<t.extra)-1,d>>>=t.extra,c-=t.extra,t.back+=t.extra}t.was=t.length,t.mode=Lc;case Lc:for(;k=t.distcode[d&(1<<t.distbits)-1],L=k>>>24,G=k>>>16&255,P=k&65535,!(L<=c);){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(!(G&240)){for(T=L,$=G,q=P;k=t.distcode[q+((d&(1<<T+$)-1)>>T)],L=k>>>24,G=k>>>16&255,P=k&65535,!(T+L<=c);){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}d>>>=T,c-=T,t.back+=T}if(d>>>=L,c-=L,t.back+=L,G&64){e.msg="invalid distance code",t.mode=_t;break}t.offset=P,t.extra=G&15,t.mode=Nc;case Nc:if(t.extra){for(W=t.extra;c<W;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}t.offset+=d&(1<<t.extra)-1,d>>>=t.extra,c-=t.extra,t.back+=t.extra}if(t.offset>t.dmax){e.msg="invalid distance too far back",t.mode=_t;break}t.mode=Oc;case Oc:if(v===0)break e;if(m=y-v,t.offset>m){if(m=t.offset-m,m>t.whave&&t.sane){e.msg="invalid distance too far back",t.mode=_t;break}m>t.wnext?(m-=t.wnext,I=t.wsize-m):I=t.wnext-m,m>t.length&&(m=t.length),F=t.window}else F=o,I=f-t.offset,m=t.length;m>v&&(m=v),v-=m,t.length-=m;do o[f++]=F[I++];while(--m);t.length===0&&(t.mode=Wu);break;case Mc:if(v===0)break e;o[f++]=t.length,v--,t.mode=Wu;break;case Jo:if(t.wrap){for(;c<32;){if(h===0)break e;h--,d|=a[s++]<<c,c+=8}if(y-=v,e.total_out+=y,t.total+=y,t.wrap&4&&y&&(e.adler=t.check=t.flags?ir(t.check,o,y,f-y):Zo(t.check,o,y,f-y)),y=v,t.wrap&4&&(t.flags?d:qc(d))!==t.check){e.msg="incorrect data check",t.mode=_t;break}d=0,c=0}t.mode=Pc;case Pc:if(t.wrap&&t.flags){for(;c<32;){if(h===0)break e;h--,d+=a[s++]<<c,c+=8}if(t.wrap&4&&d!==(t.total&4294967295)){e.msg="incorrect length check",t.mode=_t;break}d=0,c=0}t.mode=$c;case $c:C=Iw;break e;case _t:C=_c;break e;case Uc:return vc;case Wc:default:return Fn}return e.next_out=f,e.avail_out=v,e.next_in=s,e.avail_in=h,t.hold=d,t.bits=c,(t.wsize||y!==e.avail_out&&t.mode<_t&&(t.mode<Jo||n!==pc))&&Kc(e,e.output,e.next_out,y-e.avail_out),D-=e.avail_in,y-=e.avail_out,e.total_in+=D,e.total_out+=y,t.total+=y,t.wrap&4&&y&&(e.adler=t.check=t.flags?ir(t.check,o,y,e.next_out-y):Zo(t.check,o,y,e.next_out-y)),e.data_type=t.bits+(t.last?64:0)+(t.mode===dr?128:0)+(t.mode===Uu||t.mode===Qo?256:0),(D===0&&y===0||n===pc)&&C===gi&&(C=kw),C},Uw=e=>{if(pi(e))return Fn;let n=e.state;return n.window&&(n.window=null),e.state=null,gi},Ww=(e,n)=>{if(pi(e))return Fn;const t=e.state;return t.wrap&2?(t.head=n,n.done=!1,gi):Fn},qw=(e,n)=>{const t=n.length;let a,o,s;return pi(e)||(a=e.state,a.wrap!==0&&a.mode!==$u)?Fn:a.mode===$u&&(o=1,o=Zo(o,n,t,0),o!==a.check)?_c:(s=Kc(e,n,t,t),s?(a.mode=Uc,vc):(a.havedict=1,gi))};var Gw=Hc,Hw=Zc,Zw=Gc,Xw=Mw,Vw=Xc,Kw=$w,Yw=Uw,Qw=Ww,Jw=qw,jw="pako inflate (from Nodeca project)",gr={inflateReset:Gw,inflateReset2:Hw,inflateResetKeep:Zw,inflateInit:Xw,inflateInit2:Vw,inflate:Kw,inflateEnd:Yw,inflateGetHeader:Qw,inflateSetDictionary:Jw,inflateInfo:jw};function zw(){this.text=0,this.time=0,this.xflags=0,this.os=0,this.extra=null,this.extra_len=0,this.name="",this.comment="",this.hcrc=0,this.done=!1}var em=zw;const Yc=Object.prototype.toString,{Z_NO_FLUSH:tm,Z_FINISH:nm,Z_OK:Wa,Z_STREAM_END:ef,Z_NEED_DICT:tf,Z_STREAM_ERROR:rm,Z_DATA_ERROR:Qc,Z_MEM_ERROR:im}=uc;function qu(e){this.options=sc.assign({chunkSize:1024*64,windowBits:15,to:""},e||{});const n=this.options;n.raw&&n.windowBits>=0&&n.windowBits<16&&(n.windowBits=-n.windowBits,n.windowBits===0&&(n.windowBits=-15)),n.windowBits>=0&&n.windowBits<16&&!(e&&e.windowBits)&&(n.windowBits+=32),n.windowBits>15&&n.windowBits<48&&(n.windowBits&15||(n.windowBits|=15)),this.err=0,this.msg="",this.ended=!1,this.chunks=[],this.strm=new Dw,this.strm.avail_out=0;let t=gr.inflateInit2(this.strm,n.windowBits);if(t!==Wa)throw new Error(Xo[t]);if(this.header=new em,gr.inflateGetHeader(this.strm,this.header),n.dictionary&&(typeof n.dictionary=="string"?n.dictionary=Vo.string2buf(n.dictionary):Yc.call(n.dictionary)==="[object ArrayBuffer]"&&(n.dictionary=new Uint8Array(n.dictionary)),n.raw&&(t=gr.inflateSetDictionary(this.strm,n.dictionary),t!==Wa)))throw new Error(Xo[t])}qu.prototype.push=function(e,n){const t=this.strm,a=this.options.chunkSize,o=this.options.dictionary;let s,f,h;if(this.ended)return!1;for(n===~~n?f=n:f=n===!0?nm:tm,Yc.call(e)==="[object ArrayBuffer]"?t.input=new Uint8Array(e):t.input=e,t.next_in=0,t.avail_in=t.input.length;;){for(t.avail_out===0&&(t.output=new Uint8Array(a),t.next_out=0,t.avail_out=a),s=gr.inflate(t,f),s===tf&&o&&(s=gr.inflateSetDictionary(t,o),s===Wa?s=gr.inflate(t,f):s===Qc&&(s=tf));t.avail_in>0&&s===ef&&t.state.wrap>0&&e[t.next_in]!==0;)gr.inflateReset(t),s=gr.inflate(t,f);switch(s){case rm:case Qc:case tf:case im:return this.onEnd(s),this.ended=!0,!1}if(h=t.avail_out,t.next_out&&(t.avail_out===0||s===ef))if(this.options.to==="string"){let v=Vo.utf8border(t.output,t.next_out),d=t.next_out-v,c=Vo.buf2string(t.output,v);t.next_out=d,t.avail_out=a-d,d&&t.output.set(t.output.subarray(v,v+d),0),this.onData(c)}else this.onData(t.output.length===t.next_out?t.output:t.output.subarray(0,t.next_out));if(!(s===Wa&&h===0)){if(s===ef)return s=gr.inflateEnd(this.strm),this.onEnd(s),this.ended=!0,!0;if(t.avail_in===0)break}}return!0},qu.prototype.onData=function(e){this.chunks.push(e)},qu.prototype.onEnd=function(e){e===Wa&&(this.options.to==="string"?this.result=this.chunks.join(""):this.result=sc.flattenChunks(this.chunks)),this.chunks=[],this.err=e,this.msg=this.strm.msg};function am(e,n){const t=new qu(n);if(t.push(e),t.err)throw t.msg||Xo[t.err];return t.result}function um(e,n){return n=n||{},n.raw=!0,am(e,n)}var sm=um,om={inflateRaw:sm};const{inflateRaw:fm}=om;var lm=fm;function hm(e){return lm(e.subarray(2))}class cm extends Error{constructor(n){super(n),this.code="ERR_ABORTED"}}function dm(e){e.sort((o,s)=>o.offset-s.offset);const n=[];let t,a;for(const o of e)t&&a&&o.offset-a<=2e3?(t.length=t.length+o.length-a+o.offset,t.blocks.push(o)):n.push(t={blocks:[o],length:o.length,offset:o.offset}),a=t.offset+t.length;return n}function Gu(e){if(e&&e.aborted)if(typeof DOMException>"u"){const n=new cm("aborted");throw n.code="ERR_ABORTED",n}else throw new DOMException("aborted","AbortError")}const nf=typeof TextDecoder<"u"?new TextDecoder("utf8"):void 0;function rf(e,n,t,a){return e<a&&n>=t}class Jc{constructor(n,t,a,o,s){if(this.bbi=n,this.refsByName=t,this.cirTreeOffset=a,this.isCompressed=o,this.blockType=s,this.featureCache=new Nu({cache:new Pl({maxSize:1e3}),fill:async({length:f,offset:h},v)=>this.bbi.read(f,h,{signal:v})}),!(a>=0))throw new Error("invalid cirTreeOffset!")}async readWigData(n,t,a,o,s){try{const f=this.refsByName[n];f===void 0&&o.complete();const h={chrId:f,start:t,end:a};this.cirTreePromise||(this.cirTreePromise=this.bbi.read(48,this.cirTreeOffset,s));const v=await this.cirTreePromise,c=new DataView(v.buffer).getUint32(4,!0);let D=[],y=0;const m=(L,G,P)=>{try{const $=L.subarray(G),q=new DataView($.buffer,$.byteOffset,$.length);let N=0;const C=q.getUint8(N);N+=2;const S=q.getUint16(N,!0);if(N+=2,C===1){const O=[];for(let W=0;W<S;W++){const V=q.getUint32(N,!0);N+=4;const te=q.getUint32(N,!0);N+=4;const ie=q.getUint32(N,!0);N+=4;const le=q.getUint32(N,!0);N+=4;const Fe=Number(q.getBigUint64(N,!0));N+=8;const ae=Number(q.getBigUint64(N,!0));N+=8,O.push({startChrom:V,startBase:te,endBase:le,endChrom:ie,blockOffset:Fe,blockSize:ae,offset:N})}D=D.concat(O.filter(W=>I(W)).map(W=>({offset:W.blockOffset,length:W.blockSize})))}else if(C===0){const O=[];for(let V=0;V<S;V++){const te=q.getUint32(N,!0);N+=4;const ie=q.getUint32(N,!0);N+=4;const le=q.getUint32(N,!0);N+=4;const Fe=q.getUint32(N,!0);N+=4;const ae=Number(q.getBigUint64(N,!0));N+=8,O.push({startChrom:te,startBase:ie,endChrom:le,endBase:Fe,blockOffset:ae,offset:N})}const W=O.filter(V=>I(V)).map(V=>V.blockOffset);W.length>0&&k(W,P+1)}}catch(T){o.error(T)}},I=L=>{const{startChrom:G,startBase:P,endChrom:T,endBase:$}=L;return(G<f||G===f&&P<=a)&&(T>f||T===f&&$>=t)},F=async(L,G,P)=>{try{const T=G.max-G.min,$=G.min,q=await this.featureCache.get(`${T}_${$}`,{length:T,offset:$},s==null?void 0:s.signal);for(const N of L)G.contains(N)&&(m(q,N-$,P),y-=1,y===0&&this.readFeatures(o,D,{...s,request:h}).catch(C=>{o.error(C)}))}catch(T){o.error(T)}},k=(L,G)=>{try{y+=L.length;const P=4+c*32;let T=new rc([{min:L[0],max:L[0]+P}]);for(let $=1;$<L.length;$+=1){const q=new rc([{min:L[$],max:L[$]+P}]);T=T.union(q)}T.getRanges().map($=>F(L,$,G))}catch(P){o.error(P)}};k([Number(this.cirTreeOffset)+48],1);return}catch(f){o.error(f)}}parseSummaryBlock(n,t,a){const o=[];let s=t;const f=new DataView(n.buffer,n.byteOffset,n.length);for(;s<n.byteLength;){const h=f.getUint32(s,!0);s+=4;const v=f.getUint32(s,!0);s+=4;const d=f.getUint32(s,!0);s+=4;const c=f.getUint32(s,!0);s+=4;const D=f.getFloat32(s,!0);s+=4;const y=f.getFloat32(s,!0);s+=4;const m=f.getFloat32(s,!0);s+=4,s+=4,(!a||h===a.chrId&&rf(v,d,a.start,a.end))&&o.push({start:v,end:d,maxScore:y,minScore:D,summary:!0,score:m/(c||1)})}return o}parseBigBedBlock(n,t,a,o){const s=[];let f=t;const h=n,v=new DataView(h.buffer,h.byteOffset,h.length);for(;f<n.byteLength;){const d=f,c=v.getUint32(f,!0);f+=4;const D=v.getInt32(f,!0);f+=4;const y=v.getInt32(f,!0);f+=4;let m=f;for(;m<n.length&&n[m]!==0;m++);const I=n.subarray(f,m),F=(nf==null?void 0:nf.decode(I))??I.toString();f=m+1,s.push({chromId:c,start:D,end:y,rest:F,uniqueId:`bb-${a+d}`})}return o?s.filter(d=>rf(d.start,d.end,o.start,o.end)):s}parseBigWigBlock(n,t,a){const o=n.subarray(t),s=new DataView(o.buffer,o.byteOffset,o.length);let f=0;f+=4;const h=s.getInt32(f,!0);f+=8;const v=s.getUint32(f,!0);f+=4;const d=s.getUint32(f,!0);f+=4;const c=s.getUint8(f);f+=2;const D=s.getUint16(f,!0);f+=2;const y=new Array(D);switch(c){case 1:{for(let m=0;m<D;m++){const I=s.getInt32(f,!0);f+=4;const F=s.getInt32(f,!0);f+=4;const k=s.getFloat32(f,!0);f+=4,y[m]={start:I,end:F,score:k}}break}case 2:{for(let m=0;m<D;m++){const I=s.getInt32(f,!0);f+=4;const F=s.getFloat32(f,!0);f+=4,y[m]={score:F,start:I,end:I+d}}break}case 3:{for(let m=0;m<D;m++){const I=s.getFloat32(f,!0);f+=4;const F=h+m*v;y[m]={score:I,start:F,end:F+d}}break}}return a?y.filter(m=>rf(m.start,m.end,a.start,a.end)):y}async readFeatures(n,t,a={}){try{const{blockType:o,isCompressed:s}=this,{signal:f,request:h}=a,v=dm(t);Gu(f),await Promise.all(v.map(async d=>{Gu(f);const{length:c,offset:D}=d,y=await this.featureCache.get(`${c}_${D}`,d,f);for(const m of d.blocks){Gu(f);let I=y.subarray(Number(m.offset)-Number(d.offset));switch(s&&(I=hm(I)),Gu(f),o){case"summary":{n.next(this.parseSummaryBlock(I,0,h));break}case"bigwig":{n.next(this.parseBigWigBlock(I,0,h));break}case"bigbed":{n.next(this.parseBigBedBlock(I,0,Number(m.offset)*256,h));break}default:console.warn(`Don't know what to do with ${o}`)}}})),n.complete()}catch(o){n.error(o)}}}const gm=-2003829722,jc=-2021002517;function Qi(e){return new DataView(e.buffer,e.byteOffset,e.length)}class pm{getHeader(n){return this.headerP||(this.headerP=this._getHeader(n).catch(t=>{throw this.headerP=void 0,t})),this.headerP}constructor(n){const{filehandle:t,renameRefSeqs:a=f=>f,path:o,url:s}=n;if(this.renameRefSeqs=a,t)this.bbi=t;else if(s)this.bbi=new Kh(s);else if(o)this.bbi=new Sv(o);else throw new Error("no file given")}async _getHeader(n){const t=await this._getMainHeader(n),a=await this._readChromTree(t,n);return{...t,...a}}async _getMainHeader(n,t=2e3){const a=await this.bbi.read(t,0,n),o=Qi(a),s=o.getInt32(0,!0);if(s!==gm&&s!==jc)throw new Error("not a BigWig/BigBed file");let f=0;const h=o.getInt32(f,!0);f+=4;const v=o.getUint16(f,!0);f+=2;const d=o.getUint16(f,!0);f+=2;const c=Number(o.getBigUint64(f,!0));f+=8;const D=Number(o.getBigUint64(f,!0));f+=8;const y=Number(o.getBigUint64(f,!0));f+=8;const m=o.getUint16(f,!0);f+=2;const I=o.getUint16(f,!0);f+=2;const F=Number(o.getBigUint64(f,!0));f+=8;const k=Number(o.getBigUint64(f,!0));f+=8;const L=o.getUint32(f,!0);f+=4;const G=Number(o.getBigUint64(f,!0));f+=8;const P=[];for(let N=0;N<d;N++){const C=o.getUint32(f,!0);f+=4;const S=o.getUint32(f,!0);f+=4;const O=Number(o.getBigUint64(f,!0));f+=8;const W=Number(o.getBigUint64(f,!0));f+=8,P.push({reductionLevel:C,reserved:S,dataOffset:O,indexOffset:W})}const T=h===jc?"bigbed":"bigwig";if(F>t||k>t-8*5)return this._getMainHeader(n,t*2);let $;if(k){const N=a.subarray(Number(k));let C=0;const S=Qi(N),O=Number(S.getBigUint64(C,!0));C+=8;const W=S.getFloat64(C,!0);C+=8;const V=S.getFloat64(C,!0);C+=8;const te=S.getFloat64(C,!0);C+=8;const ie=S.getFloat64(C,!0);C+=8,$={scoreMin:W,scoreMax:V,scoreSum:te,scoreSumSquares:ie,basesCovered:O}}else throw new Error("no stats");const q=new TextDecoder("utf8");return{zoomLevels:P,magic:h,extHeaderOffset:G,numZoomLevels:d,fieldCount:m,totalSummary:$,definedFieldCount:I,uncompressBufSize:L,asOffset:F,chromTreeOffset:c,totalSummaryOffset:k,unzoomedDataOffset:D,unzoomedIndexOffset:y,fileType:T,version:v,autoSql:F?q.decode(a.subarray(F,a.indexOf(0,F))):""}}async _readChromTree(n,t){const a=[],o={},s=Number(n.chromTreeOffset),f=Qi(await this.bbi.read(32,s,t));let h=0;h+=4,h+=4;const v=f.getUint32(h,!0);h+=4;const d=f.getUint32(h,!0);h+=4,h+=8;const c=new TextDecoder("utf8"),D=async y=>{const m=await this.bbi.read(4,y),I=Qi(m);let F=0;const k=I.getUint8(F);F+=1,F+=1;const L=I.getUint16(F,!0);if(F+=2,k){const G=await this.bbi.read(L*(v+d),y+F),P=Qi(G);F=0;for(let T=0;T<L;T++){const $=c.decode(G.subarray(F,F+v)).replaceAll("\0","");F+=v;const q=P.getUint32(F,!0);F+=4;const N=P.getUint32(F,!0);F+=4,o[this.renameRefSeqs($)]=q,a[q]={name:$,id:q,length:N}}}else{const G=[],P=Qi(await this.bbi.read(L*(v+8),y+F));F=0;for(let T=0;T<L;T++){F+=v;const $=Number(P.getBigUint64(F,!0));F+=8,G.push(D($))}await Promise.all(G)}};return await D(s+32),{refsByName:o,refsByNumber:a}}async getUnzoomedView(n){const{unzoomedIndexOffset:t,refsByName:a,uncompressBufSize:o,fileType:s}=await this.getHeader(n);return new Jc(this.bbi,a,t,o>0,s)}async getFeatureStream(n,t,a,o){await this.getHeader(o);const s=this.renameRefSeqs(n);let f;const{basesPerSpan:h,scale:v}=o||{};return h?f=await this.getView(1/h,o):v?f=await this.getView(v,o):f=await this.getView(1,o),new Uv(d=>{f.readWigData(s,t,a,d,o).catch(c=>{d.error(c)})})}async getFeatures(n,t,a,o){const s=await this.getFeatureStream(n,t,a,o);return(await Vv(s.pipe(Jv()))).flat()}}let _m=class extends pm{async getView(n,t){const{zoomLevels:a,refsByName:o,uncompressBufSize:s}=await this.getHeader(t),f=1/n,h=a.length-1;for(let v=h;v>=0;v-=1){const d=a[v];if(d&&d.reductionLevel<=2*f)return new Jc(this.bbi,o,d.indexOffset,s>0,"summary")}return this.getUnzoomedView(t)}};const vm=["1","2","3","4","5","6","7","8","9","10","11","12","13","14","15","16","17","18","19","20","21","22","X","Y","M"];class af{constructor(n){ge(this,"url");ge(this,"bw");this.url=n,this.bw=new _m({filehandle:new Kh(n,{fetch:So})})}async detectChromosomeNaming(){try{const n=await this.bw.getHeader(),t=Object.keys(n.refsByName||{})[0];return t?vm.includes(t):!1}catch(n){return console.error("Error detecting chromosome naming:",n),!1}}async getData(n,t){const a=await this.detectChromosomeNaming(),o=n.map(h=>{let v=a?h.chr.replace("chr",""):h.chr;return(v==="M"||v==="chrM")&&(v=a?"M":"chrM"),this.bw.getFeatures(v,h.start,h.end)}),s=await Promise.all(o);return n.forEach((h,v)=>{s[v].forEach(d=>d.chr=h.chr)}),on.flatten(s)}}const wm=1e3;class mm{constructor(n){ge(this,"maxBasesPerPixel");ge(this,"workerSource");this.maxBasesPerPixel=wm,this.workerSource=new af(n)}getData(n,t,a){return t>this.maxBasesPerPixel?Promise.resolve([]):this.workerSource.getData(n,a)}}const bm=2;class Dm{constructor(n){ge(this,"maxBasesPerPixel");ge(this,"workerSource");this.maxBasesPerPixel=bm,this.workerSource=new af(n)}getData(n,t,a){return t>this.maxBasesPerPixel?Promise.resolve([]):this.workerSource.getData(n,a)}}var Hu={InfoFields:{AA:{Number:1,Type:"String",Description:"Ancestral allele"},AC:{Number:"A",Type:"Integer",Description:"Allele count in genotypes, for each ALT allele, in the same order as listed"},AD:{Number:"R",Type:"Integer",Description:"Total read depth for each allele"},ADF:{Number:"R",Type:"Integer",Description:"Read depth for each allele on the forward strand"},ADR:{Number:"R",Type:"Integer",Description:"Read depth for each allele on the reverse strand"},AF:{Number:"A",Type:"Float",Description:"Allele frequency for each ALT allele in the same order as listed (estimated from primary data, not called genotypes)"},AN:{Number:1,Type:"Integer",Description:"Total number of alleles in called genotypes"},BQ:{Number:1,Type:"Float",Description:"RMS base quality"},CIGAR:{Number:1,Type:"Float",Description:"Cigar string describing how to align an alternate allele to the reference allele"},DB:{Number:0,Type:"Flag",Description:"dbSNP membership"},DP:{Number:1,Type:"Integer",Description:"combined depth across samples"},END:{Number:1,Type:"Integer",Description:"End position (for use with symbolic alleles)"},H2:{Number:0,Type:"Flag",Description:"HapMap2 membership"},H3:{Number:0,Type:"Flag",Description:"HapMap3 membership"},MQ:{Number:1,Type:null,Description:"RMS mapping quality"},MQ0:{Number:1,Type:"Integer",Description:"Number of MAPQ == 0 reads"},NS:{Number:1,Type:"Integer",Description:"Number of samples with data"},SB:{Number:4,Type:"Integer",Description:"Strand bias"},SOMATIC:{Number:0,Type:"Flag",Description:"Somatic mutation (for cancer genomics)"},VALIDATED:{Number:0,Type:"Flag",Description:"Validated by follow-up experiment"},"1000G":{Number:0,Type:"Flag",Description:"1000 Genomes membership"},IMPRECISE:{Number:0,Type:"Flag",Description:"Imprecise structural variation"},NOVEL:{Number:0,Type:"Flag",Description:"Indicates a novel structural variation"},SVTYPE:{Number:1,Type:"String",Description:"Type of structural variant"},SVLEN:{Number:null,Type:"Integer",Description:"Difference in length between REF and ALT alleles"},CIPOS:{Number:2,Type:"Integer",Description:"Confidence interval around POS for imprecise variants"},CIEND:{Number:2,Type:"Integer",Description:"Confidence interval around END for imprecise variants"},HOMLEN:{Type:"Integer",Description:"Length of base pair identical micro-homology at event breakpoints"},HOMSEQ:{Type:"String",Description:"Sequence of base pair identical micro-homology at event breakpoints"},BKPTID:{Type:"String",Description:"ID of the assembled alternate allele in the assembly file"},MEINFO:{Number:4,Type:"String",Description:"Mobile element info of the form NAME,START,END,POLARITY"},METRANS:{Number:4,Type:"String",Description:"Mobile element transduction info of the form CHR,START,END,POLARITY"},DGVID:{Number:1,Type:"String",Description:"ID of this element in Database of Genomic Variation"},DBVARID:{Number:1,Type:"String",Description:"ID of this element in DBVAR"},DBRIPID:{Number:1,Type:"String",Description:"ID of this element in DBRIP"},MATEID:{Number:null,Type:"String",Description:"ID of mate breakends"},PARID:{Number:1,Type:"String",Description:"ID of partner breakend"},EVENT:{Number:1,Type:"String",Description:"ID of event associated to breakend"},CILEN:{Number:2,Type:"Integer",Description:"Confidence interval around the inserted material between breakend"},DPADJ:{Type:"Integer",Description:"Read Depth of adjacency"},CN:{Number:1,Type:"Integer",Description:"Copy number of segment containing breakend"},CNADJ:{Number:null,Type:"Integer",Description:"Copy number of adjacency"},CICN:{Number:2,Type:"Integer",Description:"Confidence interval around copy number for the segment"},CICNADJ:{Number:null,Type:"Integer",Description:"Confidence interval around copy number for the adjacency"}},GenotypeFields:{AD:{Number:"R",Type:"Integer",Description:"Read depth for each allele"},ADF:{Number:"R",Type:"Integer",Description:"Read depth for each allele on the forward strand"},ADR:{Number:"R",Type:"Integer",Description:"Read depth for each allele on the reverse strand"},DP:{Number:1,Type:"Integer",Description:"Read depth"},EC:{Number:"A",Type:"Integer",Description:"Expected alternate allele counts"},FT:{Number:1,Type:"String",Description:'Filter indicating if this genotype was "called"'},GL:{Number:"G",Type:"Float",Description:"Genotype likelihoods"},GP:{Number:"G",Type:"Float",Description:"Genotype posterior probabilities"},GQ:{Number:1,Type:"Integer",Description:"Conditional genotype quality"},GT:{Number:1,Type:"String",Description:"Genotype"},HQ:{Number:2,Type:"Integer",Description:"Haplotype quality"},MQ:{Number:1,Type:"Integer",Description:"RMS mapping quality"},PL:{Number:"G",Type:"Integer",Description:"Phred-scaled genotype likelihoods rounded to the closest integer"},PQ:{Number:1,Type:"Integer",Description:"Phasing quality"},PS:{Number:1,Type:"Integer",Description:"Phase set"}},AltTypes:{DEL:{Description:"Deletion relative to the reference"},INS:{Description:"Insertion of novel sequence relative to the reference"},DUP:{Description:"Region of elevated copy number relative to the reference"},INV:{Description:"Inversion of reference sequence"},CNV:{Description:"Copy number variable region (may be both deletion and duplication)"},"DUP:TANDEM":{Description:"Tandem duplication"},"DEL:ME":{Description:"Deletion of mobile element relative to the reference"},"INS:ME":{Description:"Insertion of a mobile element relative to the reference"},NON_REF:{Description:"Represents any possible alternative allele at this location"},"*":{Description:"Represents any possible alternative allele at this location"}},FilterTypes:{PASS:{Description:"Passed all filters"}}};function xm(e){Object.assign(this,e)}function ym(e){try{return decodeURIComponent(e)}catch{return e}}class Em{constructor({header:n="",strict:t=!0}){if(!n||!n.length)throw new Error("empty header received");const a=n.split(/[\r\n]+/).filter(v=>v);if(!a.length)throw new Error("no non-empty header lines specified");this.strict=t,this.metadata=JSON.parse(JSON.stringify({INFO:Hu.InfoFields,FORMAT:Hu.GenotypeFields,ALT:Hu.AltTypes,FILTER:Hu.FilterTypes}));let o;if(a.forEach(v=>{if(v.startsWith("#"))v.startsWith("##")?this._parseMetadata(v):o=v;else throw new Error(`Bad line in header:
-${v}`)}),!o)throw new Error("No format line found in header");const s=o.trim().split("	"),f=s.slice(0,8),h=["#CHROM","POS","ID","REF","ALT","QUAL","FILTER","INFO"];if(s.length<8)throw new Error(`VCF header missing columns:
-${o}`);if(f.length!==h.length||!f.every((v,d)=>v===h[d]))throw new Error(`VCF column headers not correct:
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_i(e,e.istate.nowrap!=0?null:this,1<<n),this.inflateReset(e),He)},Ur.prototype.inflate=function(e,n){var t,a;if(e==null||e.istate==null||e.next_in==null)return Bn;for(n=n==Lm?ar:He,t=ar;;)switch(e.istate.mode){case rd:if(e.avail_in==0)return t;if(t=n,e.avail_in--,e.total_in++,((e.istate.method=e.next_in[e.next_in_index++])&15)!=Nm){e.istate.mode=Sn,e.msg="unknown compression method",e.istate.marker=5;break}if((e.istate.method>>4)+8>e.istate.wbits){e.istate.mode=Sn,e.msg="invalid window size",e.istate.marker=5;break}e.istate.mode=id;case id:if(e.avail_in==0)return t;if(t=n,e.avail_in--,e.total_in++,a=e.next_in[e.next_in_index++]&255,((e.istate.method<<8)+a)%31!=0){e.istate.mode=Sn,e.msg="incorrect header check",e.istate.marker=5;break}if(!(a&km)){e.istate.mode=qa;break}e.istate.mode=ad;case ad:if(e.avail_in==0)return t;t=n,e.avail_in--,e.total_in++,e.istate.need=(e.next_in[e.next_in_index++]&255)<<24&4278190080,e.istate.mode=ud;case ud:if(e.avail_in==0)return t;t=n,e.avail_in--,e.total_in++,e.istate.need+=(e.next_in[e.next_in_index++]&255)<<16&16711680,e.istate.mode=sd;case sd:if(e.avail_in==0)return t;t=n,e.avail_in--,e.total_in++,e.istate.need+=(e.next_in[e.next_in_index++]&255)<<8&65280,e.istate.mode=od;case od:return e.avail_in==0?t:(t=n,e.avail_in--,e.total_in++,e.istate.need+=e.next_in[e.next_in_index++]&255,e.adler=e.istate.need,e.istate.mode=uf,Om);case uf:return e.istate.mode=Sn,e.msg="need dictionary",e.istate.marker=0,Bn;case qa:if(t=e.istate.blocks.proc(e,t),t==st){e.istate.mode=Sn,e.istate.marker=0;break}if(t==He&&(t=n),t!=pr)return t;if(t=n,e.istate.blocks.reset(e,e.istate.was),e.istate.nowrap!=0){e.istate.mode=Zu;break}e.istate.mode=fd;case fd:if(e.avail_in==0)return t;t=n,e.avail_in--,e.total_in++,e.istate.need=(e.next_in[e.next_in_index++]&255)<<24&4278190080,e.istate.mode=ld;case ld:if(e.avail_in==0)return t;t=n,e.avail_in--,e.total_in++,e.istate.need+=(e.next_in[e.next_in_index++]&255)<<16&16711680,e.istate.mode=hd;case hd:if(e.avail_in==0)return t;t=n,e.avail_in--,e.total_in++,e.istate.need+=(e.next_in[e.next_in_index++]&255)<<8&65280,e.istate.mode=cd;case cd:if(e.avail_in==0)return t;if(t=n,e.avail_in--,e.total_in++,e.istate.need+=e.next_in[e.next_in_index++]&255,e.istate.was[0]!=e.istate.need){e.istate.mode=Sn,e.msg="incorrect data check",e.istate.marker=5;break}e.istate.mode=Zu;case Zu:return pr;case Sn:return st;default:return Bn}},Ur.prototype.inflateSetDictionary=function(e,n,t){var a=0,o=t;return e==null||e.istate==null||e.istate.mode!=uf?Bn:e._adler.adler32(1,n,0,t)!=e.adler?st:(e.adler=e._adler.adler32(0,null,0,0),o>=1<<e.istate.wbits&&(o=(1<<e.istate.wbits)-1,a=t-o),e.istate.blocks.set_dictionary(n,a,o),e.istate.mode=qa,He)};var Xm=[0,0,255,255];Ur.prototype.inflateSync=function(e){var n,t,a,o,s;if(e==null||e.istate==null)return Bn;if(e.istate.mode!=Sn&&(e.istate.mode=Sn,e.istate.marker=0),(n=e.avail_in)==0)return ar;for(t=e.next_in_index,a=e.istate.marker;n!=0&&a<4;)e.next_in[t]==Xm[a]?a++:e.next_in[t]!=0?a=0:a=4-a,t++,n--;return e.total_in+=t-e.next_in_index,e.next_in_index=t,e.avail_in=n,e.istate.marker=a,a!=4?st:(o=e.total_in,s=e.total_out,this.inflateReset(e),e.total_in=o,e.total_out=s,e.istate.mode=qa,He)},Ur.prototype.inflateSyncPoint=function(e){return e==null||e.istate==null||e.istate.blocks==null?Bn:e.istate.blocks.sync_point()};var vd=[16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15];function _i(e,n,t){this.hufts=new Int32Array(td*3),this.window=new Uint8Array(t),this.end=t,this.checkfn=n,this.mode=Ji,this.reset(e,null),this.left=0,this.table=0,this.index=0,this.blens=null,this.bb=new Int32Array(1),this.tb=new Int32Array(1),this.codes=new Ga,this.last=0,this.bitk=0,this.bitb=0,this.read=0,this.write=0,this.check=0,this.inftree=new Ha}_i.prototype.reset=function(e,n){n&&(n[0]=this.check),this.mode==Xu&&this.codes.free(e),this.mode=Ji,this.bitk=0,this.bitb=0,this.read=this.write=0,this.checkfn&&(e.adler=this.check=e._adler.adler32(0,null,0,0))},_i.prototype.proc=function(e,n){var t,a,o,s,f,h,v;for(s=e.next_in_index,f=e.avail_in,a=this.bitb,o=this.bitk,h=this.write,v=h<this.read?this.read-h-1:this.end-h;;)switch(this.mode){case Ji:for(;o<3;){if(f!=0)n=He;else return this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);f--,a|=(e.next_in[s++]&255)<<o,o+=8}switch(t=a&7,this.last=t&1,t>>>1){case 0:a>>>=3,o-=3,t=o&7,a>>>=t,o-=t,this.mode=sf;break;case 1:{var d=new Int32Array(1),c=new Int32Array(1),D=[],y=[];Vm(d,c,D,y),this.codes.init(d[0],c[0],D[0],0,y[0],0,e)}a>>>=3,o-=3,this.mode=Xu;break;case 2:a>>>=3,o-=3,this.mode=gd;break;case 3:return a>>>=3,o-=3,this.mode=Sn,e.msg="invalid block type",n=st,this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n)}break;case sf:for(;o<32;){if(f!=0)n=He;else return this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);f--,a|=(e.next_in[s++]&255)<<o,o+=8}if((~a>>>16&65535)!=(a&65535))return this.mode=Sn,e.msg="invalid stored block lengths",n=st,this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);this.left=a&65535,a=o=0,this.mode=this.left!=0?dd:this.last!=0?Vu:Ji;break;case dd:if(f==0)return this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,write=h,this.inflate_flush(e,n);if(v==0&&(h==end&&read!=0&&(h=0,v=h<this.read?this.read-h-1:this.end-h),v==0&&(this.write=h,n=this.inflate_flush(e,n),h=this.write,v=h<this.read?this.read-h-1:this.end-h,h==this.end&&this.read!=0&&(h=0,v=h<this.read?this.read-h-1:this.end-h),v==0)))return this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);if(n=He,t=this.left,t>f&&(t=f),t>v&&(t=v),qn(e.next_in,s,this.window,h,t),s+=t,f-=t,h+=t,v-=t,(this.left-=t)!=0)break;this.mode=this.last!=0?Vu:Ji;break;case gd:for(;o<14;){if(f!=0)n=He;else return this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);f--,a|=(e.next_in[s++]&255)<<o,o+=8}if(this.table=t=a&16383,(t&31)>29||(t>>5&31)>29)return this.mode=Ku,e.msg="too many length or distance symbols",n=st,this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);if(t=258+(t&31)+(t>>5&31),this.blens==null||this.blens.length<t)this.blens=new Int32Array(t);else for(var m=0;m<t;m++)this.blens[m]=0;a>>>=14,o-=14,this.index=0;let k=pd;case pd:for(;this.index<4+(this.table>>>10);){for(;o<3;){if(f!=0)n=He;else return this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);f--,a|=(e.next_in[s++]&255)<<o,o+=8}this.blens[vd[this.index++]]=a&7,a>>>=3,o-=3}for(;this.index<19;)this.blens[vd[this.index++]]=0;if(this.bb[0]=7,t=this.inftree.inflate_trees_bits(this.blens,this.bb,this.tb,this.hufts,e),t!=He)return n=t,n==st&&(this.blens=null,this.mode=Ku),this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,write=h,this.inflate_flush(e,n);this.index=0,this.mode=_d;case _d:for(;t=this.table,this.index<258+(t&31)+(t>>5&31);){var m,I,F;for(t=this.bb[0];o<t;){if(f!=0)n=He;else return this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);f--,a|=(e.next_in[s++]&255)<<o,o+=8}if(t=this.hufts[(this.tb[0]+(a&ln[t]))*3+1],F=this.hufts[(this.tb[0]+(a&ln[t]))*3+2],F<16)a>>>=t,o-=t,this.blens[this.index++]=F;else{for(m=F==18?7:F-14,I=F==18?11:3;o<t+m;){if(f!=0)n=He;else return this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);f--,a|=(e.next_in[s++]&255)<<o,o+=8}if(a>>>=t,o-=t,I+=a&ln[m],a>>>=m,o-=m,m=this.index,t=this.table,m+I>258+(t&31)+(t>>5&31)||F==16&&m<1)return this.blens=null,this.mode=Ku,e.msg="invalid bit length repeat",n=st,this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);F=F==16?this.blens[m-1]:0;do this.blens[m++]=F;while(--I!=0);this.index=m}}this.tb[0]=-1;{var d=new Int32Array(1),c=new Int32Array(1),D=new Int32Array(1),y=new Int32Array(1);if(d[0]=9,c[0]=6,t=this.table,t=this.inftree.inflate_trees_dynamic(257+(t&31),1+(t>>5&31),this.blens,d,c,D,y,this.hufts,e),t!=He)return t==st&&(this.blens=null,this.mode=Sn),n=t,this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);this.codes.init(d[0],c[0],this.hufts,D[0],this.hufts,y[0],e)}this.mode=Xu;case Xu:if(this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,(n=this.codes.proc(this,e,n))!=pr)return this.inflate_flush(e,n);if(n=He,this.codes.free(e),s=e.next_in_index,f=e.avail_in,a=this.bitb,o=this.bitk,h=this.write,v=h<this.read?this.read-h-1:this.end-h,this.last==0){this.mode=Ji;break}this.mode=Vu;case Vu:if(this.write=h,n=this.inflate_flush(e,n),h=this.write,v=h<this.read?this.read-h-1:this.end-h,this.read!=this.write)return this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);k=Zu;case Mm:return n=pr,this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);case Ku:return n=st,this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n);default:return n=Bn,this.bitb=a,this.bitk=o,e.avail_in=f,e.total_in+=s-e.next_in_index,e.next_in_index=s,this.write=h,this.inflate_flush(e,n)}},_i.prototype.free=function(e){this.reset(e,null),this.window=null,this.hufts=null},_i.prototype.set_dictionary=function(e,n,t){qn(e,n,window,0,t),this.read=this.write=t},_i.prototype.sync_point=function(){return this.mode==sf},_i.prototype.inflate_flush=function(e,n){var t,a,o;return a=e.next_out_index,o=this.read,t=(o<=this.write?this.write:this.end)-o,t>e.avail_out&&(t=e.avail_out),t!=0&&n==ar&&(n=He),e.avail_out-=t,e.total_out+=t,this.checkfn!=null&&(e.adler=this.check=e._adler.adler32(this.check,this.window,o,t)),qn(this.window,o,e.next_out,a,t),a+=t,o+=t,o==this.end&&(o=0,this.write==this.end&&(this.write=0),t=this.write-o,t>e.avail_out&&(t=e.avail_out),t!=0&&n==ar&&(n=He),e.avail_out-=t,e.total_out+=t,this.checkfn!=null&&(e.adler=this.check=e._adler.adler32(this.check,this.window,o,t)),qn(this.window,o,e.next_out,a,t),a+=t,o+=t),e.next_out_index=a,this.read=o,n};var Yu=0,wd=1,md=2,bd=3,Dd=4,xd=5,yd=6,of=7,Ed=8,Qu=9;function Ga(){}Ga.prototype.init=function(e,n,t,a,o,s,f){this.mode=Yu,this.lbits=e,this.dbits=n,this.ltree=t,this.ltree_index=a,this.dtree=o,this.dtree_index=s,this.tree=null},Ga.prototype.proc=function(e,n,t){var a,o,s,f=0,h=0,v=0,d,c,D,y;for(v=n.next_in_index,d=n.avail_in,f=e.bitb,h=e.bitk,c=e.write,D=c<e.read?e.read-c-1:e.end-c;;)switch(this.mode){case Yu:if(D>=258&&d>=10&&(e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,t=this.inflate_fast(this.lbits,this.dbits,this.ltree,this.ltree_index,this.dtree,this.dtree_index,e,n),v=n.next_in_index,d=n.avail_in,f=e.bitb,h=e.bitk,c=e.write,D=c<e.read?e.read-c-1:e.end-c,t!=He)){this.mode=t==pr?of:Qu;break}this.need=this.lbits,this.tree=this.ltree,this.tree_index=this.ltree_index,this.mode=wd;case wd:for(a=this.need;h<a;){if(d!=0)t=He;else return e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t);d--,f|=(n.next_in[v++]&255)<<h,h+=8}if(o=(this.tree_index+(f&ln[a]))*3,f>>>=this.tree[o+1],h-=this.tree[o+1],s=this.tree[o],s==0){this.lit=this.tree[o+2],this.mode=yd;break}if(s&16){this.get=s&15,this.len=this.tree[o+2],this.mode=md;break}if(!(s&64)){this.need=s,this.tree_index=o/3+this.tree[o+2];break}if(s&32){this.mode=of;break}return this.mode=Qu,n.msg="invalid literal/length code",t=st,e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t);case md:for(a=this.get;h<a;){if(d!=0)t=He;else return e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t);d--,f|=(n.next_in[v++]&255)<<h,h+=8}this.len+=f&ln[a],f>>=a,h-=a,this.need=this.dbits,this.tree=this.dtree,this.tree_index=this.dtree_index,this.mode=bd;case bd:for(a=this.need;h<a;){if(d!=0)t=He;else return e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t);d--,f|=(n.next_in[v++]&255)<<h,h+=8}if(o=(this.tree_index+(f&ln[a]))*3,f>>=this.tree[o+1],h-=this.tree[o+1],s=this.tree[o],s&16){this.get=s&15,this.dist=this.tree[o+2],this.mode=Dd;break}if(!(s&64)){this.need=s,this.tree_index=o/3+this.tree[o+2];break}return this.mode=Qu,n.msg="invalid distance code",t=st,e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t);case Dd:for(a=this.get;h<a;){if(d!=0)t=He;else return e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t);d--,f|=(n.next_in[v++]&255)<<h,h+=8}this.dist+=f&ln[a],f>>=a,h-=a,this.mode=xd;case xd:for(y=c-this.dist;y<0;)y+=e.end;for(;this.len!=0;){if(D==0&&(c==e.end&&e.read!=0&&(c=0,D=c<e.read?e.read-c-1:e.end-c),D==0&&(e.write=c,t=e.inflate_flush(n,t),c=e.write,D=c<e.read?e.read-c-1:e.end-c,c==e.end&&e.read!=0&&(c=0,D=c<e.read?e.read-c-1:e.end-c),D==0)))return e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t);e.window[c++]=e.window[y++],D--,y==e.end&&(y=0),this.len--}this.mode=Yu;break;case yd:if(D==0&&(c==e.end&&e.read!=0&&(c=0,D=c<e.read?e.read-c-1:e.end-c),D==0&&(e.write=c,t=e.inflate_flush(n,t),c=e.write,D=c<e.read?e.read-c-1:e.end-c,c==e.end&&e.read!=0&&(c=0,D=c<e.read?e.read-c-1:e.end-c),D==0)))return e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t);t=He,e.window[c++]=this.lit,D--,this.mode=Yu;break;case of:if(h>7&&(h-=8,d++,v--),e.write=c,t=e.inflate_flush(n,t),c=e.write,D=c<e.read?e.read-c-1:e.end-c,e.read!=e.write)return e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t);this.mode=Ed;case Ed:return t=pr,e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t);case Qu:return t=st,e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t);default:return t=Bn,e.bitb=f,e.bitk=h,n.avail_in=d,n.total_in+=v-n.next_in_index,n.next_in_index=v,e.write=c,e.inflate_flush(n,t)}},Ga.prototype.free=function(e){},Ga.prototype.inflate_fast=function(e,n,t,a,o,s,f,h){var v,d,c,D,y,m,I,F,k,L,G,P,T,$,q,N;I=h.next_in_index,F=h.avail_in,y=f.bitb,m=f.bitk,k=f.write,L=k<f.read?f.read-k-1:f.end-k,G=ln[e],P=ln[n];do{for(;m<20;)F--,y|=(h.next_in[I++]&255)<<m,m+=8;if(v=y&G,d=t,c=a,N=(c+v)*3,(D=d[N])==0){y>>=d[N+1],m-=d[N+1],f.window[k++]=d[N+2],L--;continue}do{if(y>>=d[N+1],m-=d[N+1],D&16){for(D&=15,T=d[N+2]+(y&ln[D]),y>>=D,m-=D;m<15;)F--,y|=(h.next_in[I++]&255)<<m,m+=8;v=y&P,d=o,c=s,N=(c+v)*3,D=d[N];do if(y>>=d[N+1],m-=d[N+1],D&16){for(D&=15;m<D;)F--,y|=(h.next_in[I++]&255)<<m,m+=8;if($=d[N+2]+(y&ln[D]),y>>=D,m-=D,L-=T,k>=$)q=k-$,k-q>0&&2>k-q,f.window[k++]=f.window[q++],f.window[k++]=f.window[q++],T-=2;else{q=k-$;do q+=f.end;while(q<0);if(D=f.end-q,T>D){if(T-=D,k-q>0&&D>k-q)do f.window[k++]=f.window[q++];while(--D!=0);else qn(f.window,q,f.window,k,D),k+=D,q+=D,D=0;q=0}}do f.window[k++]=f.window[q++];while(--T!=0);break}else if(!(D&64))v+=d[N+2],v+=y&ln[D],N=(c+v)*3,D=d[N];else return h.msg="invalid distance code",T=h.avail_in-F,T=m>>3<T?m>>3:T,F+=T,I-=T,m-=T<<3,f.bitb=y,f.bitk=m,h.avail_in=F,h.total_in+=I-h.next_in_index,h.next_in_index=I,f.write=k,st;while(!0);break}if(D&64)return D&32?(T=h.avail_in-F,T=m>>3<T?m>>3:T,F+=T,I-=T,m-=T<<3,f.bitb=y,f.bitk=m,h.avail_in=F,h.total_in+=I-h.next_in_index,h.next_in_index=I,f.write=k,pr):(h.msg="invalid literal/length code",T=h.avail_in-F,T=m>>3<T?m>>3:T,F+=T,I-=T,m-=T<<3,f.bitb=y,f.bitk=m,h.avail_in=F,h.total_in+=I-h.next_in_index,h.next_in_index=I,f.write=k,st);if(v+=d[N+2],v+=y&ln[D],N=(c+v)*3,(D=d[N])==0){y>>=d[N+1],m-=d[N+1],f.window[k++]=d[N+2],L--;break}}while(!0)}while(L>=258&&F>=10);return T=h.avail_in-F,T=m>>3<T?m>>3:T,F+=T,I-=T,m-=T<<3,f.bitb=y,f.bitk=m,h.avail_in=F,h.total_in+=I-h.next_in_index,h.next_in_index=I,f.write=k,He};function Ha(){}Ha.prototype.huft_build=function(e,n,t,a,o,s,f,h,v,d,c){var D,y,m,I,F,k,L,G,P,T,$,q,N,C,S;T=0,F=t;do this.c[e[n+T]]++,T++,F--;while(F!=0);if(this.c[0]==t)return f[0]=-1,h[0]=0,He;for(G=h[0],k=1;k<=$r&&this.c[k]==0;k++);for(L=k,G<k&&(G=k),F=$r;F!=0&&this.c[F]==0;F--);for(m=F,G>F&&(G=F),h[0]=G,C=1<<k;k<F;k++,C<<=1)if((C-=this.c[k])<0)return st;if((C-=this.c[F])<0)return st;for(this.c[F]+=C,this.x[1]=k=0,T=1,N=2;--F!=0;)this.x[N]=k+=this.c[T],N++,T++;F=0,T=0;do(k=e[n+T])!=0&&(this.v[this.x[k]++]=F),T++;while(++F<t);for(t=this.x[m],this.x[0]=F=0,T=0,I=-1,q=-G,this.u[0]=0,$=0,S=0;L<=m;L++)for(D=this.c[L];D--!=0;){for(;L>q+G;){if(I++,q+=G,S=m-q,S=S>G?G:S,(y=1<<(k=L-q))>D+1&&(y-=D+1,N=L,k<S))for(;++k<S&&!((y<<=1)<=this.c[++N]);)y-=this.c[N];if(S=1<<k,this.hn[0]+S>td)return st;this.u[I]=$=this.hn[0],this.hn[0]+=S,I!=0?(this.x[I]=F,this.r[0]=k,this.r[1]=G,k=F>>>q-G,this.r[2]=$-this.u[I-1]-k,qn(this.r,0,v,(this.u[I-1]+k)*3,3)):f[0]=$}for(this.r[1]=L-q,T>=t?this.r[0]=192:c[T]<a?(this.r[0]=this.v[T]<256?0:96,this.r[2]=this.v[T++]):(this.r[0]=s[this.v[T]-a]+16+64,this.r[2]=o[this.v[T++]-a]),y=1<<L-q,k=F>>>q;k<S;k+=y)qn(this.r,0,v,($+k)*3,3);for(k=1<<L-1;F&k;k>>>=1)F^=k;for(F^=k,P=(1<<q)-1;(F&P)!=this.x[I];)I--,q-=G,P=(1<<q)-1}return C!=0&&m!=1?ar:He},Ha.prototype.inflate_trees_bits=function(e,n,t,a,o){var s;return this.initWorkArea(19),this.hn[0]=0,s=this.huft_build(e,0,19,19,null,null,t,n,a,this.hn,this.v),s==st?o.msg="oversubscribed dynamic bit lengths tree":(s==ar||n[0]==0)&&(o.msg="incomplete dynamic bit lengths tree",s=st),s},Ha.prototype.inflate_trees_dynamic=function(e,n,t,a,o,s,f,h,v){var d;return this.initWorkArea(288),this.hn[0]=0,d=this.huft_build(t,0,e,257,qm,Gm,s,a,h,this.hn,this.v),d!=He||a[0]==0?(d==st?v.msg="oversubscribed literal/length tree":d!=nd&&(v.msg="incomplete literal/length tree",d=st),d):(this.initWorkArea(288),d=this.huft_build(t,e,n,0,Hm,Zm,f,o,h,this.hn,this.v),d!=He||o[0]==0&&e>257?(d==st?v.msg="oversubscribed distance tree":d==ar?(v.msg="incomplete distance tree",d=st):d!=nd&&(v.msg="empty distance tree with lengths",d=st),d):He)};function Vm(e,n,t,a,o){return e[0]=Pm,n[0]=$m,t[0]=Um,a[0]=Wm,He}Ha.prototype.initWorkArea=function(e){this.hn==null&&(this.hn=new Int32Array(1),this.v=new Int32Array(e),this.c=new Int32Array($r+1),this.r=new Int32Array(3),this.u=new Int32Array($r),this.x=new Int32Array($r+1)),this.v.length<e&&(this.v=new Int32Array(e));for(var n=0;n<e;n++)this.v[n]=0;for(var n=0;n<$r+1;n++)this.c[n]=0;for(var n=0;n<3;n++)this.r[n]=0;qn(this.c,0,this.u,0,$r),qn(this.c,0,this.x,0,$r+1)};var Km=new Uint8Array(1),Ym=typeof Km.subarray=="function";function qn(e,n,t,a,o){if(o!=0){if(e){if(!t)throw"Undef dest"}else throw"Undef src";n==0&&o==e.length?ff(e,t,a):Ym?ff(e.subarray(n,n+o),t,a):e.BYTES_PER_ELEMENT==1&&o>100?ff(new Uint8Array(e.buffer,e.byteOffset+n,o),t,a):Qm(e,n,t,a,o)}}function Qm(e,n,t,a,o){for(var s=0;s<o;++s)t[a+s]=e[n+s]}function ff(e,n,t){n.set(e,t)}function Jm(e,n,t,a){n?t?e=new Uint8Array(e,n,t):e=new Uint8Array(e,n,e.byteLength-n):e=new Uint8Array(e);var o=new ji;o.inflateInit(ed,!0),o.next_in=e,o.next_in_index=0,o.avail_in=e.length;for(var s=[],f=0;;){var h=new Uint8Array(32e3);o.next_out=h,o.next_out_index=0,o.avail_out=h.length;var v=o.inflate(Rm);if(v!=He&&v!=pr&&v!=ar)throw o.msg;if(o.avail_out!=0){var d=new Uint8Array(h.length-o.avail_out);qn(h,0,d,0,h.length-o.avail_out),h=d}if(s.push(h),f+=h.length,v==pr||v==ar)break}if(s.length==1)return s[0].buffer;for(var c=new Uint8Array(f),D=0,y=0;y<s.length;++y){var m=s[y];qn(m,0,c,D,m.length),D+=m.length}return c.buffer}function Ad(){}function Fd(e){e&&(this.id=e)}typeof module<"u"&&(module.exports={DASGroup:Fd,DASFeature:Ad});var jm=2291137574,zm=654086024,eb=2273964779,tb=3958540679,nb=1,rb=2,ib=3,Cd=256,Bd=256*256,Sd=256*256*256,ab=256*256*256*256,ub=new RegExp("^[0-9]+,[0-9]+,[0-9]+");function Rt(e,n){var t=e[n]+e[n+1]*Cd+e[n+2]*Bd+e[n+3]*Sd+e[n+4]*ab;return t}function _r(){}_r.prototype.readChromTree=function(e){var n=this;this.chromsToIDs={},this.idsToChroms={},this.chrAlias={1:"chr1",2:"chr2",3:"chr3",4:"chr4",5:"chr5",6:"chr6",7:"chr7",8:"chr8",9:"chr9",10:"chr10",11:"chr11",12:"chr12",13:"chr13",14:"chr14",15:"chr15",16:"chr16",17:"chr17",18:"chr18",19:"chr19",20:"chr20",21:"chr21",22:"chr22",X:"chrX",Y:"chrY",M:"chrM",MT:"chrM"},this.maxID=0;var t=this.unzoomedDataOffset,a=t-this.chromTreeOffset&3;t=t+4-a,this.data.slice(this.chromTreeOffset,t-this.chromTreeOffset).fetch(function(o){var s=new Uint8Array(o),f=new Int16Array(o),h=new Int32Array(o);h[0],h[1];var v=h[2];h[3],Rt(s,16);var d=32,c=function(D){var y=s[D],m=f[D/2+1];D+=4;for(var I=0;I<m;++I)if(y==0){D+=v;var F=Rt(s,D);D+=8,F-=n.chromTreeOffset,c(F)}else{for(var k="",L=0;L<v;++L){var G=s[D++];G!=0&&(k+=String.fromCharCode(G))}var P=s[D+3]<<24|s[D+2]<<16|s[D+1]<<8|s[D+0];s[D+7]<<24|s[D+6]<<16|s[D+5]<<8|s[D+4],D+=8,n.chromsToIDs[k]=P,n.idsToChroms[P]=k,n.chrAlias.hasOwnProperty(k)&&(n.chromsToIDs[n.chrAlias[k]]=P,n.idsToChroms[P]=n.chrAlias[k]),n.maxID=Math.max(n.maxID,P)}};c(d),e(n)})};function Wr(e,n,t,a){this.bwg=e,this.cirTreeOffset=n,this.cirTreeLength=t,this.isSummary=a}Wr.prototype.readWigData=function(e,n,t,a){var o=this.bwg.chromsToIDs[e];if(o===void 0)return a([]);this.readWigDataById(o,n,t,a)},Wr.prototype.readWigDataById=function(e,n,t,a){var o=this;if(!this.cirHeader){this.bwg.data.slice(this.cirTreeOffset,48).fetch(function(D){o.cirHeader=D;var y=new Int32Array(o.cirHeader);o.cirBlockSize=y[1],o.readWigDataById(e,n,t,a)});return}var s=[],f=0,h=function(D,y,m,I){return(e<0||D==e)&&y<=t&&m>=n},v=function(D,y){if(o.bwg.instrument&&console.log("level="+y+"; offset="+D+"; time="+(Date.now()|0)),f+=D.length,D.length==1&&D[0]-o.cirTreeOffset==48&&o.cachedCirRoot){c(o.cachedCirRoot,0,y),--f,f==0&&o.fetchFeatures(h,s,a);return}for(var m=4+o.cirBlockSize*32,I,F=0;F<D.length;++F){var k=new nn(D[F],D[F]+m);I=I?union(I,k):k}for(var L=I.ranges(),G=0;G<L.length;++G){var P=L[G];d(D,P,y)}},d=function(D,y,m,I){y.max()-y.min(),o.bwg.data.slice(y.min(),y.max()-y.min()).fetch(function(F){for(var k=0;k<D.length;++k)y.contains(D[k])&&(c(F,D[k]-y.min(),m),D[k]-o.cirTreeOffset==48&&D[k]-y.min()==0&&(o.cachedCirRoot=F),--f,f==0&&o.fetchFeatures(h,s,a))})},c=function(D,y,m){var I=new Uint8Array(D),F=new Int16Array(D),k=new Int32Array(D),L=I[y],G=F[y/2+1];if(y+=4,L!=0)for(var P=0;P<G;++P){var T=y/4,$=k[T],q=k[T+1],N=k[T+2],C=k[T+3],S=Rt(I,y+16),O=Rt(I,y+24);(e<0||$<e||$==e&&q<=t)&&(e<0||N>e||N==e&&C>=n)&&s.push({offset:S,size:O}),y+=32}else{for(var W=[],P=0;P<G;++P){var T=y/4,$=k[T],q=k[T+1],N=k[T+2],C=k[T+3],S=Rt(I,y+16);(e<0||$<e||$==e&&q<=t)&&(e<0||N>e||N==e&&C>=n)&&W.push(S),y+=24}W.length>0&&v(W,m+1)}};v([o.cirTreeOffset+48],1)},Wr.prototype.fetchFeatures=function(e,n,t){var a=this;if(n.sort(function(h,v){return(h.offset|0)-(v.offset|0)}),n.length==0)t([]);else{var o=[],s=function(h,v,d,c){c||(c={});var D=new Ad;D._chromId=h,D.segment=a.bwg.idsToChroms[h],D.min=v,D.max=d,D.type=a.bwg.type;for(var y in c)D[y]=c[y];o.push(D)},f=function(){if(n.length==0){t(o);return}else{var h=n[0];if(h.data)a.parseFeatures(h.data,s,e),n.splice(0,1),f();else{for(var v=h.offset,d=h.size,c=1;c<n.length&&n[c].offset==v+d;)d+=n[c].size,++c;a.bwg.data.slice(v,d).fetch(function(D){for(var y=0,m=0;y<d;){var I=n[m],F;if(a.bwg.uncompressBufSize>0)F=Jm(D,y+2,I.size-2);else{var k=new Uint8Array(I.size);arrayCopy(new Uint8Array(D,y,I.size),0,k,0,I.size),F=k.buffer}I.data=F,y+=I.size,++m}f()})}}};f()}},Wr.prototype.parseFeatures=function(e,n,t){var a=new Uint8Array(e);if(this.isSummary)for(var o=new Int16Array(e),s=new Int32Array(e),f=new Float32Array(e),h=e.byteLength/32,v=0;v<h;++v){var d=s[v*8],c=s[v*8+1],D=s[v*8+2],y=s[v*8+3];f[v*8+4];var m=f[v*8+5],I=f[v*8+6];if(f[v*8+7],t(d,c+1,D)){var F={type:"bigwig",score:I/y,maxScore:m};this.bwg.type=="bigbed"&&(F.type="density"),n(d,c+1,D,F)}}else if(this.bwg.type=="bigwig"){var o=new Int16Array(e),s=new Int32Array(e),f=new Float32Array(e),d=s[0],k=s[1];s[2];var L=s[3],G=s[4],P=a[20],h=o[11];if(P==ib)for(var v=0;v<h;++v){var T=f[v+6],$=k+v*L+1,q=k+v*L+G;t(d,$,q)&&n(d,$,q,{score:T})}else if(P==rb)for(var v=0;v<h;++v){var c=s[v*2+6]+1,D=c+G-1,T=f[v*2+7];t(d,c,D)&&n(d,c,D,{score:T})}else if(P==nb)for(var v=0;v<h;++v){var c=s[v*3+6]+1,D=s[v*3+7],T=f[v*3+8];c>D&&(c=D),t(d,c,D)&&n(d,c,D,{score:T})}else console.log("Currently not handling bwgType="+P)}else if(this.bwg.type=="bigbed")for(var N=0,C=this.bwg.definedFieldCount,S=this.bwg.schema;N<a.length;){var d=a[N+3]<<24|a[N+2]<<16|a[N+1]<<8|a[N+0],c=a[N+7]<<24|a[N+6]<<16|a[N+5]<<8|a[N+4],D=a[N+11]<<24|a[N+10]<<16|a[N+9]<<8|a[N+8];N+=12;for(var O="";;){var W=a[N++];if(W!=0)O+=String.fromCharCode(W);else break}var V={},te;if(O.length>0?te=O.split("	"):te=[],te.length>0&&C>3&&(V.label=te[0]),te.length>1&&C>4){var T=parseInt(te[1]);isNaN(T)||(V.score=T)}if(te.length>2&&C>5&&(V.orientation=te[2]),te.length>5&&C>8){var ie=te[5];ub.test(ie)&&(V.itemRgb="rgb("+ie+")")}if(te.length>C-3&&S)for(var le=C-3;le<te.length;++le)V[S.fields[le+3].name]=te[le];if(t(d,c+1,D,te))if(C<12)n(d,c+1,D,V);else{var Fe=te[3]|0,ae=te[4]|0,pe=te[6]|0,_e=te[7].split(","),Xe=te[8].split(",");if(V.exonFrames){var he=V.exonFrames.split(",");V.exonFrames=void 0}V.type="transcript";var se=new Fd;for(var fe in V)se[fe]=V[fe];if(se.id=te[0],se.segment=this.bwg.idsToChroms[d],se.min=c+1,se.max=D,se.notes=[],V.groups=[se],te.length>9){var Ee=V.geneName||te[9],ve=Ee;te.length>10&&(ve=te[10]),V.geneName2&&(ve=V.geneName2);var qe=shallowCopy(se);qe.id=Ee,qe.label=ve,qe.type="gene",V.groups.push(qe)}for(var ot=[],me=0;me<pe;++me){var Be=(Xe[me]|0)+c,Ve=Be+(_e[me]|0),ce=new nn(Be,Ve);ot.push(ce)}for(var Me=union(ot),Ke=Me.ranges(),we=0;we<Ke.length;++we){var Ce=Ke[we];n(d,Ce.min()+1,Ce.max(),V)}if(ae>Fe){var Ae=V.orientation=="+"?new nn(Fe,ae+3):new nn(Fe-3,ae),je=intersection(Me,Ae);if(je){V.type="translation";for(var De=je.ranges(),Qe=0,At=0;De[0].min()>Ke[At].max();)At++;for(var we=0;we<De.length;++we){var vt=we;V.orientation=="-"&&(vt=De.length-we-1);var Ce=De[vt];if(V.readframe=Qe,he){var xt=parseInt(he[vt+At]);typeof xt=="number"&&xt>=0&&xt<=2&&(V.readframe=xt,V.readframeExplicit=!0)}var Yt=Ce.max()-Ce.min();Qe=(Qe+Yt)%3,n(d,Ce.min()+1,Ce.max(),V)}}}}}else throw Error("Don't know what to do with "+this.bwg.type)},Wr.prototype.getFirstAdjacent=function(e,n,t,a){var o=this.bwg.chromsToIDs[e];if(o===void 0)return a([]);this.getFirstAdjacentById(o,n,t,a)},Wr.prototype.getFirstAdjacentById=function(e,n,t,a){var o=this;if(!this.cirHeader){this.bwg.data.slice(this.cirTreeOffset,48).fetch(function(y){o.cirHeader=y;var m=new Int32Array(o.cirHeader);o.cirBlockSize=m[1],o.getFirstAdjacentById(e,n,t,a)});return}var s=null,f=-1,h=-1,v=0,d=function(y,m){v+=y.length;for(var I=4+o.cirBlockSize*32,F,k=0;k<y.length;++k){var L=new nn(y[k],y[k]+I);F=F?union(F,L):L}for(var G=F.ranges(),P=0;P<G.length;++P){var T=G[P];c(y,T)}},c=function(y,m,I,F){m.max()-m.min(),o.bwg.data.slice(m.min(),m.max()-m.min()).fetch(function(k){for(var L=0;L<y.length;++L)if(m.contains(y[L])&&(D(k,y[L]-m.min()),--v,v==0)){if(!s)return t>0&&(e!=0||n>0)?o.getFirstAdjacentById(0,0,t,a):t<0&&(e!=o.bwg.maxID||n<1e9)?o.getFirstAdjacentById(o.bwg.maxID,1e9,t,a):a([]);o.fetchFeatures(function(G,P,T,$){return t<0&&(G<e||T<n)||t>0&&(G>e||P>n)},[s],function(G){for(var P=null,T=-1,$=-1,q=0;q<G.length;++q){var N=G[q],C=N._chromId,S=N.min,O=N.max;(P==null||t<0&&(C>T||O>$)||t>0&&(C<T||S<$))&&(P=N,$=t<0?O:S,T=C)}return P!=null?a([P]):a([])})}})},D=function(y,m,I){var F=new Uint8Array(y),k=new Int16Array(y),L=new Int32Array(y),G=F[m],P=k[m/2+1];if(m+=4,G!=0)for(var T=0;T<P;++T){var $=m/4,q=L[$],N=L[$+1],C=L[$+2],S=L[$+3],O=Rt(F,m+16),W=Rt(F,m+24);(t<0&&(q<e||q==e&&N<=n)||t>0&&(C>e||C==e&&S>=n))&&(/_random/.exec(o.bwg.idsToChroms[q])||(s==null||t<0&&(C>f||C==f&&S>h)||t>0&&(q<f||q==f&&N<h))&&(s={offset:O,size:W},h=t<0?S:N,f=t<0?C:q)),m+=32}else{for(var V=-1,te=-1,T=0;T<P;++T){var $=m/4,q=L[$],N=L[$+1],C=L[$+2],S=L[$+3],O=L[$+4]<<32|L[$+5];(t<0&&(q<e||q==e&&N<=n)&&C>=e||t>0&&(C>e||C==e&&S>=n)&&q<=e)&&(V<0||S>te)&&(V=O,te=t<0?S:N),m+=24}V>=0&&d([V])}};d([o.cirTreeOffset+48])},_r.prototype.readWigData=function(e,n,t,a){this.getUnzoomedView().readWigData(e,n,t,a)},_r.prototype.getUnzoomedView=function(){if(!this.unzoomedView){var e=4e3,n=this.zoomLevels[0];n&&(e=this.zoomLevels[0].dataOffset-this.unzoomedIndexOffset),this.unzoomedView=new Wr(this,this.unzoomedIndexOffset,e,!1)}return this.unzoomedView},_r.prototype.getZoomedView=function(e){var n=this.zoomLevels[e];return n.view||(n.view=new Wr(this,n.indexOffset,4e3,!0)),n.view};function sb(e,n,t){var a=new _r;a.data=e,a.name=t,a.data.slice(0,512).salted().fetch(function(o){if(!o)return n(null,"Couldn't fetch file");var s=o,f=new Uint8Array(s),h=new Int16Array(s),v=new Int32Array(s),d=f[0]+Cd*f[1]+Bd*f[2]+Sd*f[3];if(d==jm)a.type="bigwig";else if(d==eb)a.type="bigbed";else return d==zm||d==tb?n(null,"Currently don't support big-endian BBI files"):n(null,"Not a supported format, magic=0x"+d.toString(16));a.version=h[2],a.numZoomLevels=h[3],a.chromTreeOffset=Rt(f,8),a.unzoomedDataOffset=Rt(f,16),a.unzoomedIndexOffset=Rt(f,24),a.fieldCount=h[16],a.definedFieldCount=h[17],a.asOffset=Rt(f,36),a.totalSummaryOffset=Rt(f,44),a.uncompressBufSize=v[13],a.extHeaderOffset=Rt(f,56),a.zoomLevels=[];for(var c=0;c<a.numZoomLevels;++c){var D=v[c*6+16],y=Rt(f,c*24+72),m=Rt(f,c*24+80);a.zoomLevels.push({reduction:D,dataOffset:y,indexOffset:m})}a.readChromTree(function(){a.getAutoSQL(function(I){return a.schema=I,n(a)})})},{timeout:5e3})}_r.prototype._tsFetch=function(e,n,t,a,o){var s=this;if(e>=this.zoomLevels.length-1)if(!this.topLevelReductionCache)this.getZoomedView(this.zoomLevels.length-1).readWigDataById(-1,0,3e8,function(c){return s.topLevelReductionCache=c,s._tsFetch(e,n,t,a,o)});else{for(var f=[],h=this.topLevelReductionCache,v=0;v<h.length;++v)h[v]._chromId==n&&f.push(h[v]);return o(f)}else{var d;return e<0?d=this.getUnzoomedView():d=this.getZoomedView(e),d.readWigDataById(n,t,a,o)}},_r.prototype.thresholdSearch=function(e,n,t,a,o){t=t<0?-1:1;for(var s=this,f=this.chromsToIDs[e],h=[{chrOrd:0,chr:f,zoom:s.zoomLevels.length-4,min:0,max:3e8,fromRef:!0}],v=1;v<=this.maxID+1;++v){var d=(f+t*v)%(this.maxID+1);d<0&&(d+=this.maxID+1),h.push({chrOrd:v,chr:d,zoom:s.zoomLevels.length-1,min:0,max:3e8})}function c(){if(h.length==0)return o(null);h.sort(function(y,m){var I=y.zoom-m.zoom;return I!=0||(I=y.chrOrd-m.chrOrd,I!=0)?I:y.min-m.min*t});var D=h.splice(0,1)[0];s._tsFetch(D.zoom,D.chr,D.min,D.max,function(y){var m=t>0?0:3e8;D.fromRef&&(m=n);for(var I=0;I<y.length;++I){var F=y[I],k;if(F.maxScore!=null?k=F.maxScore:k=F.score,t>0){if(k>a)if(D.zoom<0){if(F.min>m)return o(F)}else F.max>m&&h.push({chr:D.chr,chrOrd:D.chrOrd,zoom:D.zoom-2,min:F.min,max:F.max,fromRef:D.fromRef})}else if(k>a)if(D.zoom<0){if(F.max<m)return o(F)}else F.min<m&&h.push({chr:D.chr,chrOrd:D.chrOrd,zoom:D.zoom-2,min:F.min,max:F.max,fromRef:D.fromRef})}c()})}c()},_r.prototype.getAutoSQL=function(e){if(!this.asOffset)return e(null);this.data.slice(this.asOffset,2048).fetch(function(n){for(var t=new Uint8Array(n),a="",o=0;o<t.length&&t[o]!=0;++o)a+=String.fromCharCode(t[o]);var s=/(\w+)\s+(\w+)\s+("([^"]+)")?\s+\(\s*/,f=/([\w\[\]]+)\s+(\w+)\s*;\s*("([^"]+)")?\s*/g,h=s.exec(a);if(h){var v={declType:h[1],name:h[2],comment:h[4],fields:[]};a=a.substring(h[0]);for(var d=f.exec(a);d!=null;d=f.exec(a))v.fields.push({type:d[1],name:d[2],comment:d[4]});return e(v)}})},_r.prototype.getExtraIndices=function(e){var n=this;if(this.version<4||this.extHeaderOffset==0||this.type!="bigbed")return e(null);this.data.slice(this.extHeaderOffset,64).fetch(function(t){if(!t)return e(null,"Couldn't fetch extension header");var a=new Uint8Array(t),o=new Int16Array(t);o[0];var s=o[1],f=Rt(a,4);if(s==0)return e(null);n.data.slice(f,s*20).fetch(function(h){if(!h)return e(null,"Couldn't fetch index info");for(var v=new Uint8Array(h),d=new Int16Array(h),c=[],D=0;D<s;++D){var y=d[D*10],m=d[D*10+1],I=Rt(v,D*20+4),F=d[D*10+8],k=new Id(n,y,m,I,F);c.push(k)}e(c)})})};function Id(e,n,t,a,o){this.bbi=e,this.type=n,this.fieldCount=t,this.offset=a,this.field=o}Id.prototype.lookup=function(e,n){var t=this;this.bbi.data.slice(this.offset,32).fetch(function(a){var o=new Uint8Array(a),s=new Int32Array(a);s[0];var f=s[1],h=s[2],v=s[3];Rt(o,16);var d=32;function c(D){t.bbi.data.slice(D,4+f*(h+v)).fetch(function(y){var m=new Uint8Array(y),I=new Uint16Array(y),F=m[0],k=I[1],L=4;if(F==0){for(var G=null,P=0;P<k;++P){for(var T="",$=0;$<h;++$){var q=m[L++];q!=0&&(T+=String.fromCharCode(q))}var N=Rt(m,L);if(L+=8,e.localeCompare(T)<0&&G){c(G);return}G=N}c(G)}else{for(var P=0;P<k;++P){for(var T="",$=0;$<h;++$){var q=m[L++];q!=0&&(T+=String.fromCharCode(q))}if(T==e){var C=Rt(m,L),S=readInt(m,L+8);return t.bbi.getUnzoomedView().fetchFeatures(function(V,te,ie,le){if(le&&le.length>t.field-3)return le[t.field-3]==e},[{offset:C,size:S}],n)}L+=v}return n([])}})}c(t.offset+d)})};var ob="";function fb(e){return lb(Td(kd(e)))}function lf(e){return hb(Td(kd(e)))}function Td(e){return db(gb(cb(e),e.length*8))}function lb(e){for(var n="0123456789abcdef",t="",a,o=0;o<e.length;o++)a=e.charCodeAt(o),t+=n.charAt(a>>>4&15)+n.charAt(a&15);return t}function hb(e){for(var n="ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/",t="",a=e.length,o=0;o<a;o+=3)for(var s=e.charCodeAt(o)<<16|(o+1<a?e.charCodeAt(o+1)<<8:0)|(o+2<a?e.charCodeAt(o+2):0),f=0;f<4;f++)o*8+f*6>e.length*8?t+=ob:t+=n.charAt(s>>>6*(3-f)&63);return t}function kd(e){for(var n="",t=-1,a,o;++t<e.length;)a=e.charCodeAt(t),o=t+1<e.length?e.charCodeAt(t+1):0,55296<=a&&a<=56319&&56320<=o&&o<=57343&&(a=65536+((a&1023)<<10)+(o&1023),t++),a<=127?n+=String.fromCharCode(a):a<=2047?n+=String.fromCharCode(192|a>>>6&31,128|a&63):a<=65535?n+=String.fromCharCode(224|a>>>12&15,128|a>>>6&63,128|a&63):a<=2097151&&(n+=String.fromCharCode(240|a>>>18&7,128|a>>>12&63,128|a>>>6&63,128|a&63));return n}function cb(e){for(var n=Array(e.length>>2),t=0;t<n.length;t++)n[t]=0;for(var t=0;t<e.length*8;t+=8)n[t>>5]|=(e.charCodeAt(t/8)&255)<<24-t%32;return n}function db(e){for(var n="",t=0;t<e.length*32;t+=8)n+=String.fromCharCode(e[t>>5]>>>24-t%32&255);return n}function gb(e,n){e[n>>5]|=128<<24-n%32,e[(n+64>>9<<4)+15]=n;for(var t=Array(80),a=1732584193,o=-271733879,s=-1732584194,f=271733878,h=-1009589776,v=0;v<e.length;v+=16){for(var d=a,c=o,D=s,y=f,m=h,I=0;I<80;I++){I<16?t[I]=e[v+I]:t[I]=hf(t[I-3]^t[I-8]^t[I-14]^t[I-16],1);var F=vr(vr(hf(a,5),pb(I,o,s,f)),vr(vr(h,t[I]),_b(I)));h=f,f=s,s=hf(o,30),o=a,a=F}a=vr(a,d),o=vr(o,c),s=vr(s,D),f=vr(f,y),h=vr(h,m)}return Array(a,o,s,f,h)}function pb(e,n,t,a){return e<20?n&t|~n&a:e<40?n^t^a:e<60?n&t|n&a|t&a:n^t^a}function _b(e){return e<20?1518500249:e<40?1859775393:e<60?-1894007588:-899497514}function vr(e,n){var t=(e&65535)+(n&65535),a=(e>>16)+(n>>16)+(t>>16);return a<<16|t&65535}function hf(e,n){return e<<n|e>>>32-n}typeof module<"u"&&(module.exports={b64_sha1:lf,hex_sha1:fb});function vb(e){var n={};for(var t in e)n[t]=e[t];return n}function vi(e,n,t,a){a||(typeof n=="object"?(a=n,n=void 0):a={}),this.url=e,this.start=n||0,t&&(this.end=t),this.opts=a}vi.prototype.slice=function(e,n){if(e<0)throw"Bad slice "+e;var t=this.start,a=this.end;return t&&e?t=t+e:t=e||t,n&&t?a=t+n-1:a=a||n-1,new vi(this.url,t,a,this.opts)};var Rd=0,Ld=navigator.userAgent.indexOf("Safari")>=0&&navigator.userAgent.indexOf("Chrome")<0;vi.prototype.fetchAsText=function(e){try{var n=new XMLHttpRequest,t,a=this.url;if((Ld||this.opts.salt)&&a.indexOf("?")<0&&(a=a+"?salt="+lf(""+Date.now()+","+ ++Rd)),n.open("GET",a,!0),this.end){if(this.end-this.start>1e8)throw"Monster fetch!";n.setRequestHeader("Range","bytes="+this.start+"-"+this.end),n.setRequestHeader("accept-encoding","gzip,deflate"),t=this.end-this.start+1}n.onreadystatechange=function(){if(n.readyState==4)return n.status==200||n.status==206?e(n.responseText):e(null)},this.opts.credentials&&(n.withCredentials=!0),n.send("")}catch{return e(null)}},vi.prototype.salted=function(){var e=vb(this.opts);return e.salt=!0,new vi(this.url,this.start,this.end,e)},vi.prototype.fetch=function(e,n){var t=this;n=n||{};var a=n.attempt||1,o=n.truncatedLength;if(a>3)return e(null);try{var s,f=new XMLHttpRequest,h,v=this.url;if((Ld||this.opts.salt)&&v.indexOf("?")<0&&(v=v+"?salt="+lf(""+Date.now()+","+ ++Rd)),f.open("GET",v,!0),f.overrideMimeType("text/plain; charset=x-user-defined"),this.end){if(this.end-this.start>1e8)throw"Monster fetch!";f.setRequestHeader("Range","bytes="+this.start+"-"+this.end),h=this.end-this.start+1}f.responseType="arraybuffer",f.onreadystatechange=function(){if(f.readyState==4)if(s&&clearTimeout(s),f.status==200||f.status==206)if(f.response){var d=f.response.byteLength;return h&&h!=d&&(!o||d!=o)?t.fetch(e,{attempt:a+1,truncatedLength:d}):e(f.response)}else{if(f.mozResponseArrayBuffer)return e(f.mozResponseArrayBuffer);var c=f.responseText;return h&&h!=c.length&&(!o||c.length!=o)?t.fetch(e,{attempt:a+1,truncatedLength:c.length}):e(wb(f.responseText))}else return t.fetch(e,{attempt:a+1})},this.opts.credentials&&f.setRequestHeader("Authorization",this.opts.credentials),f.send("")}catch{return e(null)}};function wb(e){if(!e)return null;for(var n=new Uint8Array(e.length),t=0;t<n.length;++t)n[t]=e.charCodeAt(t);return n.buffer}/**
- * Reads and gets data from bigwig or bigbed files hosted remotely.  Gets DASFeature records, which vary in schema
- * depending on the file.
- *
- * @license MIT
- */class mb{constructor(n){ge(this,"url");ge(this,"bigWigPromise");this.url=n,this.bigWigPromise=this.loadBigWig(n)}async loadBigWig(n){try{return new Promise((t,a)=>{sb(new vi(n),(o,s)=>{s?a(s):t(o)})})}catch(t){return console.error("Failed to dynamically load the BigWig module:",t),Promise.reject(t)}}async getData(n,t,a){const o=await this.bigWigPromise,s=a.zoomLevel===void 0||a.zoomLevel===Fm.AUTO?this._getMatchingZoomLevel(o,t):Number.parseInt(a.zoomLevel);let f=n.map(d=>this._getDataForChromosome(d,o,s));const h=await Promise.all(f),v=on.flatten(h);for(let d of v)d.min-=1;return v}_getMatchingZoomLevel(n,t){if(!t)return-1;if(n.zoomLevels.length===1)return 0;let o=n.zoomLevels.slice().sort((s,f)=>f.reduction-s.reduction).find(s=>s.reduction<t);return n.zoomLevels.findIndex(s=>s===o)}_getDataForChromosome(n,t,a){const o=n.start+1,s=n.end;return new Promise((f,h)=>{try{a===-1?t.readWigData(n.chr,o,s,f):t.getZoomedView(a).readWigData(n.chr,o,s,f)}catch(v){h(v)}})}}let qr={};const cf={WashU:"https://lambda.epigenomegateway.org/v3"},bb={geneannotation:async function(n){let t,a;const o=n.trackModel;o.apiConfig&&o.apiConfig.genome?t=o.apiConfig.genome:t=n.genomeName,o.apiConfig&&o.apiConfig.format in cf?a=cf[`${o.apiConfig.format}`]:a=cf.WashU;let s=`${a}/${t}/genes/${n.name}/queryRegion?chr=${n.chr}&start=${n.start}&end=${n.end}`;return(await fetch(s,{method:"GET"})).json()},snp:async function(n){const t={hg19:"https://grch37.rest.ensembl.org/overlap/region/human",hg38:"https://rest.ensembl.org/overlap/region/human"},a=n.genomeName in t?t[`${n.genomeName}`]:null;if(!a)return[];const o={"Content-Type":"application/json"};if(n.end-n.start<=3e4){const s=`${a}/${n.chr.substr(3)}:${n.start}-${n.end+"?content-type=application%2Fjson&feature=variation"}`;return fetch(s,{headers:o}).then(f=>{if(!f.ok)throw new Error("Network response was not ok");return f.json()}).catch(f=>(console.error("There was a problem with the fetch operation:",f),{data:[]}))}else return[]},bed:async function(n){return St(n,"bedOrTabix")},bedcolor:async function(n){return St(n,"bedOrTabix")},omeroidr:async function(n){return St(n,"bedOrTabix")},bedgraph:async function(n){return St(n,"bedOrTabix")},qbed:async function(n){return St(n,"bedOrTabix")},dbedgraph:async function(n){return St(n,"bedOrTabix")},boxplot:async function(n){return St(n,"big")},modbed:async function(n){return St(n,"bedOrTabix")},jaspar:async function(n){return St(n,"jaspar")},bigbed:async function(n){return St(n,"bigbed")},refbed:async function(n){return St(n,"bedOrTabix")},matplot:async function(n){return St(n,"bedOrTabix")},bigwig:async function(n){return St(n,"big")},categorical:async function(n){return St(n,"bedOrTabix")},longrange:async function(n){return St(n,"bedOrTabix")},dynseq:async function(n){return St(n,"big")},repeatmasker:async function(n){return St(n,"repeat")},biginteract:async function(n){return St(n,"big")},methylc:async function(n){return St(n,"bedOrTabix")},genomealign:function(n){return St(n,"bedOrTabix")},vcf:function(n){return St(n,"vcf")}};function St(e,n){let t=null;e.trackModel.indexUrl&&(t=e.trackModel.indexUrl),e.trackModel.id in qr||(n==="bedOrTabix"?qr[`${e.trackModel.id}`]=new Fv(e.trackModel.url,t):n==="vcf"?qr[`${e.trackModel.id}`]=new Am(e.trackModel.url,t):n==="bigbed"?qr[`${e.trackModel.id}`]=new mb(e.trackModel.url):n==="big"?qr[`${e.trackModel.id}`]=new af(e.trackModel.url):n==="repeat"?qr[`${e.trackModel.id}`]=new mm(e.trackModel.url):n==="jaspar"&&(qr[`${e.trackModel.id}`]=new Dm(e.trackModel.url)));let a=qr[`${e.trackModel.id}`];return n in{repeat:"",jaspar:"",bigbed:""}?a.getData(e.nav,e.basesPerPixel,e.trackModel.options):a.getData(e.nav,e.trackModel.options)}var Db={exports:{}};/* @license
-Papa Parse
-v5.5.3
-https://github.com/mholt/PapaParse
-License: MIT
-*/(function(e,n){((t,a)=>{e.exports=a()})(vn,function t(){var a=typeof self<"u"?self:typeof window<"u"?window:a!==void 0?a:{},o,s=!a.document&&!!a.postMessage,f=a.IS_PAPA_WORKER||!1,h={},v=0,d={};function c(C){this._handle=null,this._finished=!1,this._completed=!1,this._halted=!1,this._input=null,this._baseIndex=0,this._partialLine="",this._rowCount=0,this._start=0,this._nextChunk=null,this.isFirstChunk=!0,this._completeResults={data:[],errors:[],meta:{}},(function(S){var O=$(S);O.chunkSize=parseInt(O.chunkSize),S.step||S.chunk||(O.chunkSize=null),this._handle=new F(O),(this._handle.streamer=this)._config=O}).call(this,C),this.parseChunk=function(S,O){var W=parseInt(this._config.skipFirstNLines)||0;if(this.isFirstChunk&&0<W){let te=this._config.newline;te||(V=this._config.quoteChar||'"',te=this._handle.guessLineEndings(S,V)),S=[...S.split(te).slice(W)].join(te)}this.isFirstChunk&&N(this._config.beforeFirstChunk)&&(V=this._config.beforeFirstChunk(S))!==void 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V;this._config.chunkSize&&(V=this._start+this._config.chunkSize-1,S.setRequestHeader("Range","bytes="+this._start+"-"+V));try{S.send(this._config.downloadRequestBody)}catch(te){this._chunkError(te.message)}s&&S.status===0&&this._chunkError()}},this._chunkLoaded=function(){S.readyState===4&&(S.status<200||400<=S.status?this._chunkError():(this._start+=this._config.chunkSize||S.responseText.length,this._finished=!this._config.chunkSize||this._start>=(O=>(O=O.getResponseHeader("Content-Range"))!==null?parseInt(O.substring(O.lastIndexOf("/")+1)):-1)(S),this.parseChunk(S.responseText)))},this._chunkError=function(O){O=S.statusText||O,this._sendError(new Error(O))}}function y(C){(C=C||{}).chunkSize||(C.chunkSize=d.LocalChunkSize),c.call(this,C);var S,O,W=typeof FileReader<"u";this.stream=function(V){this._input=V,O=V.slice||V.webkitSlice||V.mozSlice,W?((S=new FileReader).onload=q(this._chunkLoaded,this),S.onerror=q(this._chunkError,this)):S=new 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S=[],O=!0,W=!1;this.pause=function(){c.prototype.pause.apply(this,arguments),this._input.pause()},this.resume=function(){c.prototype.resume.apply(this,arguments),this._input.resume()},this.stream=function(V){this._input=V,this._input.on("data",this._streamData),this._input.on("end",this._streamEnd),this._input.on("error",this._streamError)},this._checkIsFinished=function(){W&&S.length===1&&(this._finished=!0)},this._nextChunk=function(){this._checkIsFinished(),S.length?this.parseChunk(S.shift()):O=!0},this._streamData=q(function(V){try{S.push(typeof V=="string"?V:V.toString(this._config.encoding)),O&&(O=!1,this._checkIsFinished(),this.parseChunk(S.shift()))}catch(te){this._streamError(te)}},this),this._streamError=q(function(V){this._streamCleanUp(),this._sendError(V)},this),this._streamEnd=q(function(){this._streamCleanUp(),W=!0,this._streamData("")},this),this._streamCleanUp=q(function(){this._input.removeListener("data",this._streamData),this._input.removeListener("end",this._streamEnd),this._input.removeListener("error",this._streamError)},this)}function F(C){var S,O,W,V,te=Math.pow(2,53),ie=-te,le=/^\s*-?(\d+\.?|\.\d+|\d+\.\d+)([eE][-+]?\d+)?\s*$/,Fe=/^((\d{4}-[01]\d-[0-3]\dT[0-2]\d:[0-5]\d:[0-5]\d\.\d+([+-][0-2]\d:[0-5]\d|Z))|(\d{4}-[01]\d-[0-3]\dT[0-2]\d:[0-5]\d:[0-5]\d([+-][0-2]\d:[0-5]\d|Z))|(\d{4}-[01]\d-[0-3]\dT[0-2]\d:[0-5]\d([+-][0-2]\d:[0-5]\d|Z)))$/,ae=this,pe=0,_e=0,Xe=!1,he=!1,se=[],fe={data:[],errors:[],meta:{}};function Ee(me){return C.skipEmptyLines==="greedy"?me.join("").trim()==="":me.length===1&&me[0].length===0}function ve(){if(fe&&W&&(ot("Delimiter","UndetectableDelimiter","Unable to auto-detect delimiting character; defaulted to '"+d.DefaultDelimiter+"'"),W=!1),C.skipEmptyLines&&(fe.data=fe.data.filter(function(ce){return!Ee(ce)})),qe()){let ce=function(Me,Ke){N(C.transformHeader)&&(Me=C.transformHeader(Me,Ke)),se.push(Me)};if(fe)if(Array.isArray(fe.data[0])){for(var me=0;qe()&&me<fe.data.length;me++)fe.data[me].forEach(ce);fe.data.splice(0,1)}else fe.data.forEach(ce)}function Be(ce,Me){for(var Ke=C.header?{}:[],we=0;we<ce.length;we++){var Ce=we,Ae=ce[we],Ae=((je,De)=>(Qe=>(C.dynamicTypingFunction&&C.dynamicTyping[Qe]===void 0&&(C.dynamicTyping[Qe]=C.dynamicTypingFunction(Qe)),(C.dynamicTyping[Qe]||C.dynamicTyping)===!0))(je)?De==="true"||De==="TRUE"||De!=="false"&&De!=="FALSE"&&((Qe=>{if(le.test(Qe)&&(Qe=parseFloat(Qe),ie<Qe&&Qe<te))return 1})(De)?parseFloat(De):Fe.test(De)?new Date(De):De===""?null:De):De)(Ce=C.header?we>=se.length?"__parsed_extra":se[we]:Ce,Ae=C.transform?C.transform(Ae,Ce):Ae);Ce==="__parsed_extra"?(Ke[Ce]=Ke[Ce]||[],Ke[Ce].push(Ae)):Ke[Ce]=Ae}return C.header&&(we>se.length?ot("FieldMismatch","TooManyFields","Too many fields: expected "+se.length+" fields but parsed "+we,_e+Me):we<se.length&&ot("FieldMismatch","TooFewFields","Too few fields: expected "+se.length+" fields but parsed "+we,_e+Me)),Ke}var Ve;fe&&(C.header||C.dynamicTyping||C.transform)&&(Ve=1,!fe.data.length||Array.isArray(fe.data[0])?(fe.data=fe.data.map(Be),Ve=fe.data.length):fe.data=Be(fe.data,0),C.header&&fe.meta&&(fe.meta.fields=se),_e+=Ve)}function qe(){return C.header&&se.length===0}function ot(me,Be,Ve,ce){me={type:me,code:Be,message:Ve},ce!==void 0&&(me.row=ce),fe.errors.push(me)}N(C.step)&&(V=C.step,C.step=function(me){fe=me,qe()?ve():(ve(),fe.data.length!==0&&(pe+=me.data.length,C.preview&&pe>C.preview?O.abort():(fe.data=fe.data[0],V(fe,ae))))}),this.parse=function(me,Be,Ve){var ce=C.quoteChar||'"',ce=(C.newline||(C.newline=this.guessLineEndings(me,ce)),W=!1,C.delimiter?N(C.delimiter)&&(C.delimiter=C.delimiter(me),fe.meta.delimiter=C.delimiter):((ce=((Me,Ke,we,Ce,Ae)=>{var je,De,Qe,At;Ae=Ae||[",","	","|",";",d.RECORD_SEP,d.UNIT_SEP];for(var vt=0;vt<Ae.length;vt++){for(var xt,Yt=Ae[vt],yt=0,nt=0,wt=0,Ft=(Qe=void 0,new L({comments:Ce,delimiter:Yt,newline:Ke,preview:10}).parse(Me)),dt=0;dt<Ft.data.length;dt++)we&&Ee(Ft.data[dt])?wt++:(xt=Ft.data[dt].length,nt+=xt,Qe===void 0?Qe=xt:0<xt&&(yt+=Math.abs(xt-Qe),Qe=xt));0<Ft.data.length&&(nt/=Ft.data.length-wt),(De===void 0||yt<=De)&&(At===void 0||At<nt)&&1.99<nt&&(De=yt,je=Yt,At=nt)}return{successful:!!(C.delimiter=je),bestDelimiter:je}})(me,C.newline,C.skipEmptyLines,C.comments,C.delimitersToGuess)).successful?C.delimiter=ce.bestDelimiter:(W=!0,C.delimiter=d.DefaultDelimiter),fe.meta.delimiter=C.delimiter),$(C));return C.preview&&C.header&&ce.preview++,S=me,O=new L(ce),fe=O.parse(S,Be,Ve),ve(),Xe?{meta:{paused:!0}}:fe||{meta:{paused:!1}}},this.paused=function(){return Xe},this.pause=function(){Xe=!0,O.abort(),S=N(C.chunk)?"":S.substring(O.getCharIndex())},this.resume=function(){ae.streamer._halted?(Xe=!1,ae.streamer.parseChunk(S,!0)):setTimeout(ae.resume,3)},this.aborted=function(){return he},this.abort=function(){he=!0,O.abort(),fe.meta.aborted=!0,N(C.complete)&&C.complete(fe),S=""},this.guessLineEndings=function(Me,ce){Me=Me.substring(0,1048576);var ce=new RegExp(k(ce)+"([^]*?)"+k(ce),"gm"),Ve=(Me=Me.replace(ce,"")).split("\r"),ce=Me.split(`
-`),Me=1<ce.length&&ce[0].length<Ve[0].length;if(Ve.length===1||Me)return`
-`;for(var Ke=0,we=0;we<Ve.length;we++)Ve[we][0]===`
-`&&Ke++;return Ke>=Ve.length/2?`\r
-`:"\r"}}function k(C){return C.replace(/[.*+?^${}()|[\]\\]/g,"\\$&")}function L(C){var S=(C=C||{}).delimiter,O=C.newline,W=C.comments,V=C.step,te=C.preview,ie=C.fastMode,le=null,Fe=!1,ae=C.quoteChar==null?'"':C.quoteChar,pe=ae;if(C.escapeChar!==void 0&&(pe=C.escapeChar),(typeof S!="string"||-1<d.BAD_DELIMITERS.indexOf(S))&&(S=","),W===S)throw new Error("Comment character same as delimiter");W===!0?W="#":(typeof W!="string"||-1<d.BAD_DELIMITERS.indexOf(W))&&(W=!1),O!==`
-`&&O!=="\r"&&O!==`\r
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o=this._features.find(c=>c.getName()===n);if(o){const c=this.convertFeatureSegmentToContextCoordinates(new In(o)),D=.5*(c.start+c.end);return new Ye(D-3,D+3)}if(n.includes(":")&&n.includes("-")){const[c,D]=n.split(":"),[y,m]=D.split("-"),I=Math.round(parseFloat(y)),F=Math.round(parseFloat(m)),k=`${c}:${I}-${F}`,L=it.parse(k),G=this.convertGenomeIntervalToBases(L)[0];if(G)return G;throw new RangeError("Location unavailable in this context")}const s=it.parse(n),f=this.convertGenomeIntervalToBases(s)[0];if(f)return f;throw new RangeError("Location unavailable in this context")}getFeaturesInInterval(n,t,a=!0){const o=new Ye(n,t),s=[];for(const f of this._features){if(!a&&Hn.isGapFeature(f))continue;const h=this.getFeatureStart(f),v=h+f.getLength(),d=new Ye(h,v).getOverlap(o);if(d){const c=d.start-h,D=d.end-h,y=new In(f,c,D);s.push(this._flipIfReverseStrand(y))}else if(s.length>0)break}return s}getLociInInterval(n,t){const o=this.getFeaturesInInterval(n,t,!1).map(s=>s.getLocus());return it.mergeOverlaps(o)}hasFeatureWithName(n){return this._features.some(t=>t.name===n.name)}}var $d=Number.isNaN||function(n){return typeof n=="number"&&n!==n};function Rb(e,n){return!!(e===n||$d(e)&&$d(n))}function Lb(e,n){if(e.length!==n.length)return!1;for(var t=0;t<e.length;t++)if(!Rb(e[t],n[t]))return!1;return!0}function Nb(e,n){n===void 0&&(n=Lb);var t=null;function a(){for(var o=[],s=0;s<arguments.length;s++)o[s]=arguments[s];if(t&&t.lastThis===this&&n(o,t.lastArgs))return t.lastResult;var f=e.apply(this,o);return t={lastResult:f,lastArgs:o,lastThis:this},f}return a.clear=function(){t=null},a}const Va="-";function es(e){return on.sumBy(e,n=>n===Va?0:1)}function Ud(e,n,t=!1){const a=[],o=new RegExp(Va+"+","g");let s;for(;(s=o.exec(e))!==null;)v(!0,s.index,s[0].length,n);if(t)return a;let f=0;const h=a.slice();for(const d of h)v(!1,f,d.index-f),f=d.index+d.length;return v(!1,f,e.length-f),a;function v(d,c,D,y=0){D>y&&a.push({isGap:d,index:c,length:D})}}function Df(e,n,t=!1){const a=t?-1:1,o=[];let s=n;for(const f of e)o.push(s),f!==Va&&(s+=a);return o}class Ob{constructor(n){ge(this,"sequence");ge(this,"_currentIndex");this.sequence=n,this._currentIndex=-1}reset(){this._currentIndex=0}getCurrentIndex(){return this._currentIndex}getIndexOfNextBase(){do this._currentIndex++;while(this.sequence.charAt(this._currentIndex)===Va);return this._currentIndex}hasNextBase(){return this._currentIndex<this.sequence.length-1}advanceN(n){let t=this._currentIndex;for(let a=0;a<n;a++)t=this.getIndexOfNextBase();return t}}class xf extends In{constructor(t,a,o){super(t,a,o);ge(this,"feature");ge(this,"sequenceInterval");this.feature=t;const s=new Ob(t.targetSeq),f=s.advanceN(this.relativeStart+1),h=s.advanceN(this.getLength());this.sequenceInterval=new Ye(f,h)}static fromFeatureSegment(t){return new xf(t.feature,t.relativeStart,t.relativeEnd)}getTargetSequence(){const[t,a]=this.sequenceInterval;return this.feature.targetSeq.substring(t,a)}getQueryLocus(){const{queryStrand:t,queryLocus:a}=this.feature;return new it(a.chr,t==="+"?Math.min(a.start+this.relativeStart,a.end):Math.max(0,a.end-this.relativeEnd),t==="+"?Math.min(a.start+this.relativeEnd,a.end):a.end-this.relativeStart)}getQueryLocusFine(){const{querySeq:t,queryLocus:a}=this.feature,o=es(t.substring(0,this.sequenceInterval.start)),s=es(this.getQuerySequence());if(this.feature.getIsReverseStrandQuery()){const f=a.end-o;return new it(a.chr,f-s,f)}else{const f=a.start+o;return new it(a.chr,f,f+s)}}getQuerySequence(){const[t,a]=this.sequenceInterval;return this.feature.querySeq.substring(t,a)}}function Mb(e,n=!1){const t=e>=1e3?Math.floor(e):Math.round(e);return t>=75e4?`${(t/1e6).toFixed(1)} Mb`:t>=1e4?`${(t/1e3).toFixed(1)} Kb`:t>0?`${t} bp`:n?"<1 bp":"0 bp"}class Wd{constructor(n){ge(this,"_baseNavContext");ge(this,"_gaps");ge(this,"_cumulativeGapBases");this._baseNavContext=n,this._cumulativeGapBases=[]}setGaps(n){this._gaps=n.slice().sort((a,o)=>a.contextBase-o.contextBase),this._cumulativeGapBases=[];let t=0;for(const a of this._gaps)this._cumulativeGapBases.push(t),t+=a.length;this._cumulativeGapBases.push(t)}build(){const n=this._baseNavContext.getFeatures(),t=new Map;for(let f=0;f<n.length;f++)t.set(n[f],f);const a=[];let o=-1,s=0;for(const f of this._gaps){const h=this._baseNavContext.convertBaseToFeatureCoordinate(f.contextBase),v=h.feature,d=t.get(v),c=h.relativeStart;a.push(...n.slice(o+1,d)),d===o&&s>0&&a.pop(),s=s>c?0:s;const D=new In(v,s,c).getLocus(),y=new In(v,c).getLocus();D.getLength()>0&&a.push(new Yn(v.getName(),D,v.getStrand())),a.push(Hn.makeGap(f.length,`${Mb(f.length)} gap`)),y.getLength()>0&&a.push(new Yn(v.getName(),y,v.getStrand())),o=d,s=c}return a.push(...n.slice(o+1)),new Hn(this._baseNavContext.getName(),a)}convertOldCoordinates(n){const t=on.sortedIndexBy(this._gaps,{contextBase:n},"contextBase"),a=this._cumulativeGapBases[t]||0;return n+a}}class bi{constructor(n,t){ge(this,"_viewRegion");ge(this,"_drawWidth");ge(this,"_pixelsPerBase");ge(this,"_basesPerPixel");this._viewRegion=n,this._drawWidth=t,this._pixelsPerBase=t/n.getWidth(),this._basesPerPixel=n.getWidth()/t}getDrawWidth(){return this._drawWidth}basesToXWidth(n){return n*this._pixelsPerBase}xWidthToBases(n){return n*this._basesPerPixel}baseToX(n){return(n-this._viewRegion.getContextCoordinates().start)*this._pixelsPerBase}xToBase(n){return n*this._basesPerPixel+this._viewRegion.getContextCoordinates().start}baseSpanToXSpan(n){const t=this.baseToX(n.start),a=this.baseToX(n.end);return new Ye(t,a)}baseSpanToXCenter(n){const t=this.baseSpanToXSpan(n),a=Math.round((t.start+t.end)/2);return new Ye(a,a)}xToSegmentCoordinate(n){const t=Math.floor(this.xToBase(n));return this._viewRegion.getNavigationContext().convertBaseToFeatureCoordinate(t)}}class Pb{constructor(n,t,a){ge(this,"interaction");ge(this,"xSpan1");ge(this,"xSpan2");this.interaction=n,t.start<=a.start?(this.xSpan1=t,this.xSpan2=a):(this.xSpan1=a,this.xSpan2=t)}getWidth(){const n=this.xSpan1.start;return Math.max(this.xSpan1.end,this.xSpan2.end)-n}generateKey(){return""+this.xSpan1.start+this.xSpan1.end+this.xSpan2.start+this.xSpan2.end}}class $b{placeFeatures(n,t,a,o=!1){const s=new bi(t,a),f=t.getContextCoordinates(),h=t.getNavigationContext(),v=[];for(const d of n)for(let c of d.computeNavContextCoordinates(h))if(c=c.getOverlap(f),c){const D=o?s.baseSpanToXCenter(c):s.baseSpanToXSpan(c),{visiblePart:y,isReverse:m}=this._locatePlacement(d,h,c);v.push({feature:d,visiblePart:y,contextLocation:c,xSpan:D,isReverse:m})}return v}_locatePlacement(n,t,a){const o=t.convertBaseToFeatureCoordinate(a.start),s=o.getLocus().start,f=o.feature.getIsReverseStrand();let h;f?h=s-a.getLength()+1:h=s;const v=h-n.getLocus().start,d=Math.max(0,v);return{visiblePart:new In(n,d,d+a.getLength()),isReverse:f}}placeFeatureSegments(n,t){const a=n.xSpan.getLength()/n.contextLocation.getLength(),o=[];for(let s of t)if(s=s.getOverlap(n.visiblePart),s){const h=(s.relativeStart-n.visiblePart.relativeStart)*a,v=s.getLength()*a;let d;n.isReverse?d=n.xSpan.end-h-v:d=n.xSpan.start+h,o.push({segment:s,xSpan:new Ye(d,d+v)})}return o}placeInteractions(n,t,a){const o=new bi(t,a),s=t.getContextCoordinates(),f=t.getNavigationContext(),h=[];for(const v of n){let d=f.convertGenomeIntervalToBases(v.locus1),c=f.convertGenomeIntervalToBases(v.locus2);d=d.map(D=>D.getOverlap(s)),c=c.map(D=>D.getOverlap(s));for(const D of d)for(const y of c)if(D&&y){const m=o.baseSpanToXSpan(D),I=o.baseSpanToXSpan(y);h.push(new Pb(v,m,I))}}return h}placeGraphNodes(n,t,a){const o=new bi(t,a),s=t.getContextCoordinates(),f=t.getNavigationContext(),h=[],v=[];for(const d of n)for(let c of d.computeNavContextCoordinates(f))if(c=c.getOverlap(s),c){const D=o.baseSpanToXSpan(c),{visiblePart:y,isReverse:m}=this._locatePlacement(d,f,c);h.push({feature:d,visiblePart:y,contextLocation:c,xSpan:D,isReverse:m})}else v.push(d);return{placements:h,nodesOutOfView:v}}}const Ub=10,yf=5,qd=.99,Wb=200,qb=5,Gb=new $b;class Hb{constructor(n){ge(this,"primaryGenome");this.primaryGenome=n,this.multiAlign=Nb(this.multiAlign)}multiAlign(n,t){const{visRegion:a,visWidth:o,viewWindowRegion:s}=n,h=new bi(a,o).xWidthToBases(1)<Ub;let v;if(h){const d=t,{newRecordsArray:c,allGaps:D}=this.refineRecordsArray(d,n);v=c;const y=this.calculatePrimaryVis(D,n);return v.reduce((m,I)=>({...m,[I.query]:I.isBigChain?this.alignRough(I.id,I.query,I.records,n):this.alignFine(I.id,I.query,I.records,n,y,D)}),{})}else return v=t,v.reduce((d,c)=>({...d,[c.query]:this.alignRough(c.id,c.query,c.records,n)}),{})}calculatePrimaryVis(n,t){const{visRegion:a,viewWindow:o,viewWindowRegion:s}=t,f=a.getNavigationContext(),h=new Wd(f);h.setGaps(n);const v=h.build(),d=F(a),c=F(s),D=o.getLength()/c.getWidth(),y=d.getWidth()*D,I=new bi(d,y).baseSpanToXSpan(c.getContextCoordinates());return{visRegion:d,visWidth:y,viewWindowRegion:c,viewWindow:I};function F(k){const[L,G]=k.getContextCoordinates();return new Ii(v,h.convertOldCoordinates(L),h.convertOldCoordinates(G))}}refineRecordsArray(n,t){const a=qd,o=[],s={};for(const d of n){const c=this._computeContextLocations(d.records,t),y=this._getPrimaryGenomeGaps(c,a).reduce((m,I)=>({...m,[I.contextBase]:I.length}),{});o.push({recordsObj:d,placements:c,primaryGapsObj:y});for(const m of Object.keys(y))m in s?s[m]=Math.max(s[m],y[m]):s[m]=y[m]}const f=[];for(const d of Object.keys(s))f.push({contextBase:Number(d),length:s[d]});if(f.sort((d,c)=>d.contextBase-c.contextBase),o.length>1)for(const d of o){const c=[];for(const D of Object.keys(s))if(D in d.primaryGapsObj){const y=s[D]-d.primaryGapsObj[D];y>0&&c.push({contextBase:Number(D),length:y})}else c.push({contextBase:Number(D),length:s[D]});c.sort((D,y)=>y.contextBase-D.contextBase);for(const D of c){const y="-".repeat(D.length),m=D.contextBase,I=d.placements.filter(F=>F.contextSpan.start<m&&F.contextSpan.end>m)[0];if(I){const F=I.visiblePart.getTargetSequence(),k=v(F,m-I.contextSpan.start),L=I.visiblePart.sequenceInterval.start+k,G=I.record.targetSeq,P=I.record.querySeq;I.record.targetSeq=G.slice(0,L)+y+G.slice(L),I.record.querySeq=P.slice(0,L)+y+P.slice(L)}}d.recordsObj.records=d.placements.map(D=>D.record)}return{newRecordsArray:o.map(d=>d.recordsObj),allGaps:f};function v(d,c){let D=0;for(const y of d)if(D++,y!==Va&&c--,c===0)break;return D}}alignFine(n,t,a,o,s,f){const{visRegion:h,visWidth:v}=s,d=new bi(h,v),c=qd,D=o.visRegion.getNavigationContext(),y=this._computeContextLocations(a,o),m=new Wd(D);m.setGaps(f);for(const P of y){const T=P.contextSpan,$=P.visiblePart,q=new Ye(m.convertOldCoordinates(T.start),m.convertOldCoordinates(T.end)),N=d.baseSpanToXSpan(q),C=$.getTargetSequence(),S=$.getQuerySequence();P.contextSpan=q,P.targetXSpan=N,P.queryXSpan=N,P.targetSegments=this._placeSequenceSegments(C,c,N.start,d),P.querySegments=this._placeSequenceSegments(S,c,N.start,d)}const I=[],F=new Ef(yf),k=new Ef(yf);for(let P=1;P<y.length;P++){const T=y[P-1],$=y[P],q=T.targetXSpan.end,N=$.targetXSpan.start,C=T.record.locus.chr,S=T.record.locus.end,O=T.record.queryLocus.chr,W=T.record.queryStrand,V=W==="+"?T.record.queryLocus.end:T.record.queryLocus.start,te=$.record.locus.chr,ie=$.record.locus.start,le=$.record.queryLocus.chr,Fe=$.record.queryStrand,ae=Fe==="+"?$.record.queryLocus.start:$.record.queryLocus.end;let pe;O===le?W==="+"&&Fe==="+"?(pe=ae>=V?"":"overlap ",pe+=Vi(Math.abs(ae-V))):W==="-"&&Fe==="-"?(pe=V>=ae?"":"overlap ",pe+=Vi(Math.abs(V-ae))):pe="reverse direction":pe="not connected";const _e=(q+N)/2,Xe=(T.queryXSpan.end+$.queryXSpan.start)/2,he=C===te?Vi(ie-S):"not connected",fe=.5*(he.length*5),Ee=_e-fe,ve=_e+fe,qe=Ee<=q||ve>=N,ot=qe?F.place(new Ye(Ee,ve)):new Ye(Ee,ve),me=new Ye(q,N),Ve=.5*(pe.length*5),ce=Xe-Ve,Me=Xe+Ve,Ke=ce<=T.queryXSpan.end||Me>=$.queryXSpan.start,we=Ke?k.place(new Ye(ce,Me)):new Ye(ce,Me),Ce=new Ye(T.queryXSpan.end,$.queryXSpan.start);I.push({targetGapText:he,targetXSpan:me,targetTextXSpan:ot,queryGapText:pe,queryXSpan:Ce,queryTextXSpan:we,shiftTarget:qe,shiftQuery:Ke})}const L=this._getQueryPieces(y),G=this._makeQueryGenomeRegion(L,v,d);return{id:n,isFineMode:!0,primaryVisData:s,queryRegion:G,drawData:y,drawGapText:I,primaryGenome:this.primaryGenome,queryGenome:t,basesPerPixel:d.xWidthToBases(1),navContextBuilder:m}}alignRough(n,t,a,o){const{visRegion:s,visWidth:f}=o,h=new bi(s,f),v=h.xWidthToBases(Wb),c=a.reduce((F,k)=>F+(k.getIsReverseStrandQuery()?-1*k.getLength():k.getLength()),0)<0?"-":"+",D=this._computeContextLocations(a,o);let y=it.mergeAdvanced(D,v,F=>F.visiblePart.getQueryLocus());y=y.sort((F,k)=>k.locus.getLength()-F.locus.getLength());const m=new Ef(yf),I=[];for(const F of y){const k=F.locus,L=F.sources,G=h.basesToXWidth(k.getLength()),P=.5*G;if(G<qb)continue;const T=Zb(L.map(ie=>ie.targetXSpan)),$=Math.min(...L.map(ie=>ie.targetXSpan.start)),q=Math.max(...L.map(ie=>ie.targetXSpan.end)),N=new Ye($,q),C=T-P,S=T+P,O=m.place(new Ye(C,S)),W=L.map(ie=>ie.record.queryLocus),V=c==="-",te=this._placeInternalLoci(k,W,O,V,h);for(let ie=0;ie<W.length;ie++)L[ie].queryXSpan=te[ie];I.push({queryFeature:new Yn(void 0,k,c),targetXSpan:N,queryXSpan:O,segments:L})}return{id:n,isFineMode:!1,primaryVisData:o,queryRegion:this._makeQueryGenomeRegion(I,f,h),drawData:I,plotStrand:c,primaryGenome:this.primaryGenome,queryGenome:t,basesPerPixel:h.xWidthToBases(1)}}_computeContextLocations(n,t){const{visRegion:a,visWidth:o}=t;return Gb.placeFeatures(n,a,o).map(s=>({record:s.feature,visiblePart:xf.fromFeatureSegment(s.visiblePart),contextSpan:s.contextLocation,targetXSpan:s.xSpan,queryXSpan:null}))}_getPrimaryGenomeGaps(n,t){const a=[];for(const o of n){const{visiblePart:s,contextSpan:f}=o,h=Ud(s.getTargetSequence(),t,!0),v=Df(s.getTargetSequence(),f.start);for(const d of h)a.push({contextBase:v[d.index],length:d.length})}return a}_placeSequenceSegments(n,t,a,o){const s=Ud(n,t);s.sort((h,v)=>h.index-v.index);let f=a;for(const h of s){const v=h.isGap?h.length:es(n.substr(h.index,h.length)),d=o.basesToXWidth(v);h.xSpan=new Ye(f,f+d),f+=d}return s}_getQueryPieces(n){const t=[];for(const a of n){const{record:o,visiblePart:s}=a,f=o.getIsReverseStrandQuery(),h=s.getQuerySequence();let v;f?v=Df(h,s.getQueryLocusFine().end,!0):v=Df(h,s.getQueryLocusFine().start);const d=o.queryLocus.chr;for(const c of a.querySegments){const{isGap:D,index:y,length:m,xSpan:I}=c;if(D)continue;const F=v[y],k=es(h.substr(y,m));let L;f?L=new it(d,F-k,F):L=new it(d,F,F+k),t.push({queryFeature:new Yn(void 0,L,o.queryStrand),queryXSpan:I})}}return t}_makeQueryGenomeRegion(n,t,a){const o=n.slice().sort((d,c)=>d.queryXSpan.start-c.queryXSpan.start),s=[];let f=0,h=new it("",-1,-1);for(const d of o){const{queryXSpan:c,queryFeature:D}=d,y=D.getLocus(),m=c.start-f,I=Math.round(a.xWidthToBases(m));if(I>=1){const F=Xb(y,h)?`${Vi(I)} gap`:void 0;s.push(Hn.makeGap(I,F))}s.push(D),f=c.end,h=y}const v=Math.round(a.xWidthToBases(t-f));return v>0&&s.push(Hn.makeGap(v)),new Ii(new Hn("",s))}_placeInternalLoci(n,t,a,o,s){const f=[];if(o)for(const h of t){const v=h.start-n.start,d=s.basesToXWidth(v),c=a.end-d,D=s.basesToXWidth(h.getLength()),y=c<a.end?c:a.end,m=c-D>a.start?c-D:a.start;f.push(new Ye(m,y))}else for(const h of t){const v=h.start-n.start,d=s.basesToXWidth(v),c=a.start+d,D=s.basesToXWidth(h.getLength()),y=c>a.start?c:a.start,m=c+D<a.end?c+D:a.end;f.push(new Ye(y,m))}return f}}class Ef{constructor(n=0){ge(this,"leftExtent");ge(this,"rightExtent");ge(this,"margin");ge(this,"_placements");this.leftExtent=1/0,this.rightExtent=-1/0,this.margin=n,this._placements=[]}place(n){let t=n;if(this._placements.some(a=>a.getOverlap(n)!=null)){const a=.5*(n.start+n.end);t=Math.abs(a-this.leftExtent)<Math.abs(a-this.rightExtent)?new Ye(this.leftExtent-n.getLength(),this.leftExtent):new Ye(this.rightExtent,this.rightExtent+n.getLength())}return this._placements.push(t),t.start<this.leftExtent&&(this.leftExtent=t.start-this.margin),t.end>this.rightExtent&&(this.rightExtent=t.end+this.margin),t}retrievePlacements(){return this._placements}}function Zb(e){const n=on.sumBy(e,a=>.5*a.getLength()*(a.start+a.end)),t=on.sumBy(e,a=>a.getLength());return n/t}function Xb(e,n){return e.chr!==n.chr?!1:e.end===n.start||n.end===e.start}async function Vb(e){const n=e.regionExpandLoci,t=e.trackToFetch,a=e.genomicLoci,o={},s={},f={},h=e.useFineModeNav,v=e.primaryGenName,d=e.initGenomicLoci;f[`${v}`]={genomicLoci:a,regionExpandLoci:n,initGenomicLoci:d};const c=t,D=[n];c.length>0&&await y(e.visData.visRegion,c);async function y(I,F){let k=[];for(let O of e.visData.visRegion._navContext._features){let W=new it(O.locus.chr,O.locus.start,O.locus.end);k.push(new Yn(O.name,W))}let L=new Hn(e.visData.visRegion._navContext._name,k),G=new Ii(L,I._startBase,I._endBase),P=[];for(let O of e.visData.viewWindowRegion._navContext._features){let W=new it(O.locus.chr,O.locus.start,O.locus.end);P.push(new Yn(O.name,W))}let T=new Hn(e.visData.viewWindowRegion._navContext._name,P),$=new Ii(T,e.visData.viewWindowRegion._startBase,e.visData.viewWindowRegion._endBase),q={visWidth:e.visData.visWidth,visRegion:G,viewWindow:new Ye(e.windowWidth,e.windowWidth*2),viewWindowRegion:$};await Promise.all(F.map(async(O,W)=>{let V;await Promise.all(D.map(async(te,ie)=>{try{const le=await bb.genomealign({nav:te,options:{height:40,isCombineStrands:!1,colorsForContext:{CG:{color:"rgb(100,139,216)",background:"#d9d9d9"},CHG:{color:"rgb(255,148,77)",background:"#ffe0cc"},CHH:{color:"rgb(255,0,255)",background:"#ffe5ff"}},depthColor:"#525252",depthFilter:0,maxMethyl:1,label:""},url:O.url,trackModel:O});let Fe=[];for(const ae of le){let pe=kb.parse("{"+ae[3]+"}");ae[3]=pe,Fe.push(new Dp(ae))}V=Fe,s[`${O.id}`]=""}catch{V={error:`Error fetching genome align track with id ${O.id}`}}})),o[`${O.id}`]={name:O.name,records:V,query:O.querygenome,id:O.id,trackModel:O,metadata:O.metadata,isBigChain:!1}}));let N=[];for(const O in o)"error"in o[O].records||N.push(o[O]);let S=new Hb(e.primaryGenName).multiAlign(q,N);for(let O in S){let W;if(!h){W=[].concat.apply([],S[`${O}`].drawData.map(se=>se.segments));const ie=W.map(se=>se.record.queryStrand),le=W.map(se=>se.targetXSpan),Fe=W.map(se=>se.queryXSpan),ae=W.map(se=>se.visiblePart.getLocus().toString()),pe=W.map(se=>se.visiblePart.getQueryLocus().toString()),_e=W.map(se=>Vi(se.visiblePart.getLength())),Xe=W.map(se=>Vi(se.visiblePart.getQueryLocus().getLength()));let he={};he={strandList:ie,targetXSpanList:le,queryXSpanList:Fe,targetLocusList:ae,queryLocusList:pe,lengthList:_e,queryLengthList:Xe},S[`${O}`]={...S[`${O}`],...he}}for(let ie=0;ie<S[`${O}`].drawData.length;ie++){let le=S[`${O}`].drawData[ie],Fe={};const{targetXSpan:ae}=le;if(h){const pe=le.visiblePart.getTargetSequence(),_e=le.visiblePart.getQuerySequence(),Xe=ae.getLength()/pe.length,he=le.visiblePart.getLocus().toString(),se=le.visiblePart.getQueryLocus().toString(),fe=le.visiblePart.getQueryLocusFine(),Ee=le.targetSegments.filter(ot=>!ot.isGap),ve=le.querySegments.filter(ot=>!ot.isGap),qe=le.record.getIsReverseStrandQuery();Fe={targetSequence:pe,querySequence:_e,nonGapsQuery:ve,baseWidth:Xe,targetLocus:he,queryLocus:se,nonGapsTarget:Ee,isReverseStrandQuery:qe,queryLocusFine:fe}}else Fe={estimatedLabelWidth:le.queryFeature.toString().length};S[`${O}`].drawData[ie]={...le,...Fe}}let V=[],te=S[`${O}`].queryRegion._navContext._featuresForChr;for(let ie in te)if(ie!==""){let le=m(te[`${ie}`][0].name).start,Fe=m(te[`${ie}`][te[`${ie}`].length-1].name).end;V.push({chr:ie,start:le,end:Fe})}f[`${v}`].primaryVisData=S[`${O}`].primaryVisData,f[`${O}`]={queryGenomicCoord:new Array(V),id:S[`${O}`].id,queryRegion:S[`${O}`].queryRegion},o[`${S[`${O}`].id}`].records=S[`${O}`]}}function m(I){const[F,k]=I.split(":"),[L,G]=k.split("-"),P=F.slice(3),T=parseInt(L,10),$=parseInt(G,10);return{chr:P,start:T,end:$}}return{fetchResults:o,navData:{...e,genomicFetchCoord:f,trackToDrawId:s,regionSetStartBp:e.visData.visRegion._endBase-e.visData.visRegion._startBase===e.bpRegionSize?0:null}}}typeof self<"u"&&"postMessage"in self&&"onmessage"in self&&typeof self.importScripts<"u"&&(self.onmessage=async e=>{try{const n=await Vb(e.data);postMessage(n)}catch(n){console.error("Worker error:",n),postMessage({error:n instanceof Error?n.message:"Unknown error"})}})})();