react-mutation-mapper 0.8.59 → 0.8.61

package/dist/index.es.js

@@ -1,28 +1,26 @@
-import { __extends, __decorate, __spreadArrays, __assign, __awaiter, __generator } from 'tslib';
+import { __extends, __decorate, __awaiter, __generator, __assign, __spreadArrays } from 'tslib';
 import * as _ from 'lodash';
 import ___default from 'lodash';
-import { makeObservable, observable, action, computed, reaction } from 'mobx';
+import { makeObservable, observable, computed, action, reaction } from 'mobx';
 import { observer } from 'mobx-react';
 import * as React from 'react';
-import React__default, { useState } from 'react';
-import { DefaultTooltip, TruncatedText, getNCBIlink, trimOffHtmlTagEntities, cachePostMethodsOnClient, CanonicalMutationType, MutationTumorTypeFrequencyTable, FREQUENCY_COLUMNS_DEFINITION, FrequencyTableColumnEnum, CheckedSelect, getSelectedValuesMap, Checklist, MUT_COLOR_MISSENSE, MUT_COLOR_MISSENSE_PASSENGER, MUT_COLOR_INFRAME, MUT_COLOR_INFRAME_PASSENGER, MUT_COLOR_TRUNC, MUT_COLOR_TRUNC_PASSENGER, MUT_COLOR_SPLICE, MUT_COLOR_SPLICE_PASSENGER, STRUCTURAL_VARIANT_COLOR, STRUCTURAL_VARIANT_PASSENGER_COLOR, MUT_COLOR_OTHER, getCanonicalMutationType, getProteinImpactTypeFromCanonical, ProteinImpactType, getProteinImpactType, resolveColumnVisibility, resolveColumnVisibilityByColumnDefinition, longestCommonStartingSubstring, getTextWidth, unhoverAllComponents, SVGAxis, getComponentIndex, defaultHitzoneConfig, initHitZoneFromConfig, EditableSpan, DownloadControls, EllipsisTextTooltip, remoteData, WindowWrapper } from 'cbioportal-frontend-commons';
-import { CIVIC_NA_VALUE, deriveStructuralVariantType, generateQueryStructuralVariantId, generateQueryVariantId, OncoKbCardDataType, parseMyCancerGenomeLink, defaultArraySortMethod, defaultSortMethod, LEVELS, uniqueGenomicLocations, indexAnnotationsByGenomicLocation, getCivicEntry, getRemoteDataGroupStatus, getMyCancerGenomeLinks, isLinearClusterHotspot, is3dHotspot, calculateOncoKbAvailableDataType, getVariantAnnotation, getDbsnpRsId, getMyVariantInfoAnnotation, generateHgvsgByMutation, calcProteinChangeSortValue, Pathogenicity, extendMutations, formatNumberValueInSignificantDigits, generateTumorTypeDecomposition, formatPercentValue, countMutationsByProteinChange, numberOfLeadingDecimalZeros, filterLinearClusterHotspotsByMutations, filter3dHotspotsByMutations, isHotspot, defaultHotspotFilter, defaultStringArraySortMethod, extractExonInformation, formatExonLocation, formatExonLength, ptmColor, compareByPtmTypePriority, UniprotTopologyTrackToColor, UniprotTopologyTypeToTitle, PtmSource, PTM_SOURCE_URL, getMyVariantInfoAnnotationsFromIndexedVariantAnnotations, generateProteinChangeQuery, StructuralVariantType, generateAnnotateStructuralVariantQuery, getMyCancerGenomeData, genomicLocationString, convertUniprotFeatureToPtm, convertDbPtmToPtm, UniprotCategory, convertUniprotFeatureToUniprotTopology, groupPtmDataByPosition, groupPtmDataByTypeAndPosition, groupCancerHotspotDataByPosition, indexHotspotsData, fetchCivicGenes, fetchCivicVariants, getMutationsByTranscriptId, groupMutationsByProteinStartPos, groupHotspotsByMutations } from 'cbioportal-utils';
-import classnames from 'classnames';
-import autobind from 'autobind-decorator';
-import oncoKbLogoImgSrc from 'oncokb-styles/dist/images/logo/oncokb.svg';
-import { Tabs, Tab, Modal, ButtonGroup } from 'react-bootstrap';
-import { Collapse } from 'react-collapse';
-import ReactTable from 'react-table';
-import { If, Then, Else } from 'react-if';
-import 'oncokb-styles/dist/oncokb.css';
+import { DefaultTooltip, TruncatedText, getNCBIlink, cachePostMethodsOnClient, CanonicalMutationType, MutationTumorTypeFrequencyTable, FREQUENCY_COLUMNS_DEFINITION, FrequencyTableColumnEnum, CheckedSelect, getSelectedValuesMap, Checklist, MUT_COLOR_MISSENSE, MUT_COLOR_MISSENSE_PASSENGER, MUT_COLOR_INFRAME, MUT_COLOR_INFRAME_PASSENGER, MUT_COLOR_TRUNC, MUT_COLOR_TRUNC_PASSENGER, MUT_COLOR_SPLICE, MUT_COLOR_SPLICE_PASSENGER, STRUCTURAL_VARIANT_COLOR, STRUCTURAL_VARIANT_PASSENGER_COLOR, MUT_COLOR_OTHER, getCanonicalMutationType, getProteinImpactTypeFromCanonical, ProteinImpactType, getProteinImpactType, resolveColumnVisibility, resolveColumnVisibilityByColumnDefinition, longestCommonStartingSubstring, getTextWidth, unhoverAllComponents, SVGAxis, getComponentIndex, defaultHitzoneConfig, initHitZoneFromConfig, EditableSpan, DownloadControls, EllipsisTextTooltip, remoteData, WindowWrapper } from 'cbioportal-frontend-commons';
+import classNames from 'classnames';
+import { CIVIC_NA_VALUE, parseMyCancerGenomeLink, uniqueGenomicLocations, indexAnnotationsByGenomicLocation, getCivicEntry, getRemoteDataGroupStatus, getMyCancerGenomeLinks, isLinearClusterHotspot, is3dHotspot, OncoKbCardDataType, defaultArraySortMethod, getVariantAnnotation, defaultSortMethod, getDbsnpRsId, getMyVariantInfoAnnotation, generateHgvsgByMutation, calcProteinChangeSortValue, Pathogenicity, extendMutations, formatNumberValueInSignificantDigits, generateTumorTypeDecomposition, formatPercentValue, countMutationsByProteinChange, numberOfLeadingDecimalZeros, filterLinearClusterHotspotsByMutations, filter3dHotspotsByMutations, isHotspot, defaultHotspotFilter, extractExonInformation, formatExonLocation, formatExonLength, ptmColor, compareByPtmTypePriority, UniprotTopologyTrackToColor, UniprotTopologyTypeToTitle, PtmSource, PTM_SOURCE_URL, getMyVariantInfoAnnotationsFromIndexedVariantAnnotations, getMyCancerGenomeData, genomicLocationString, convertUniprotFeatureToPtm, convertDbPtmToPtm, UniprotCategory, convertUniprotFeatureToUniprotTopology, groupPtmDataByPosition, groupPtmDataByTypeAndPosition, groupCancerHotspotDataByPosition, indexHotspotsData, fetchCivicGenes, fetchCivicVariants, getMutationsByTranscriptId, groupMutationsByProteinStartPos, groupHotspotsByMutations } from 'cbioportal-utils';
+import { getIndicatorData, calculateOncoKbAvailableDataType, oncoKbAnnotationSortValue, OncoKB, OncoKbSummaryTable, LEVELS, getTumorTypeNameWithExclusionInfo, ReferenceList, generateProteinChangeQuery, StructuralVariantType, generateAnnotateStructuralVariantQuery, defaultOncoKbFilter, groupOncoKbIndicatorDataByMutations, defaultOncoKbIndicatorFilter } from 'oncokb-frontend-commons';
 import { GenomeNexusAPI, GenomeNexusAPIInternal } from 'genome-nexus-ts-api-client';
 import { OncoKbAPI } from 'oncokb-ts-api-client';
+import autobind from 'autobind-decorator';
+import ReactTable from 'react-table';
 import 'rc-tooltip/assets/bootstrap_white.css';
 import Select, { components } from 'react-select';
 import $ from 'jquery';
+import { Collapse } from 'react-collapse';
 import Slider from 'react-rangeslider';
 import 'react-rangeslider/lib/index.css';
 import oncoKbImg from 'oncokb-styles/dist/images/oncogenic.svg';
+import 'oncokb-frontend-commons/dist/styles.css';
+import { ButtonGroup } from 'react-bootstrap';
 import request, { get } from 'superagent';
 import memoize from 'memoize-weak-decorator';
 import { cached } from 'mobxpromise';
@@ -30,7 +28,7 @@ import { cached } from 'mobxpromise';
 var annotationStyles = {"annotation-item-load":"annotation-module_annotation-item-load__1pDN0","annotation-item-text":"annotation-module_annotation-item-text__Gy_Jv","annotation-item-error":"annotation-module_annotation-item-error__5BhTo","annotation-item":"annotation-module_annotation-item__2EgnB"};
 
 function loaderIcon(className) {
-    return (React.createElement("span", { className: classnames("" + annotationStyles['annotation-item'], "" + annotationStyles['annotation-item-load'], className) },
+    return (React.createElement("span", { className: classNames("" + annotationStyles['annotation-item'], "" + annotationStyles['annotation-item-load'], className) },
         React.createElement("i", { className: "fa fa-spinner fa-pulse" })));
 }
 function errorIcon(errorMessage) {
@@ -127,1607 +125,58 @@ var CivicCard = /** @class */ (function (_super) {
                             React.createElement("p", null,
                                 React.createElement("span", { className: "civic-card-gene-name" },
                                     React.createElement("a", { href: this.props.geneUrl, target: "_blank" },
-                                        React.createElement("b", null, this.props.geneName))),
-                                ' ',
-                                "- ",
-                                this.props.geneDescription)),
-                        React.createElement("div", { className: "col s12" },
-                            React.createElement("ul", null, this.generateVariants(this.props.variants))),
-                        React.createElement("div", { className: "item disclaimer" },
-                            React.createElement("span", null, "Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.")))),
-                React.createElement("div", { className: "item footer" },
-                    React.createElement("a", { href: this.props.geneUrl, target: "_blank" },
-                        React.createElement("img", { src: img$5, className: "civic-logo", alt: "CIViC" })))));
-        }
-    });
-    return CivicCard;
-}(React.Component));
-
-var img$4 = "data:image/png;base64,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";
-
-var img$3 = "data:image/png;base64,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";
-
-function hideArrow$1(tooltipEl) {
-    var arrowEl = tooltipEl.querySelector('.rc-tooltip-arrow');
-    arrowEl.style.display = 'none';
-}
-function sortValue$8(civicEntry) {
-    var score = 0;
-    if (civicEntry) {
-        score = 1;
-    }
-    return score;
-}
-function download$7(civicEntry) {
-    if (!civicEntry) {
-        return CIVIC_NA_VALUE;
-    }
-    var variants = ___default.values(civicEntry.variants);
-    var values = [];
-    if (variants && variants.length > 0 && variants[0].evidenceCounts) {
-        ___default.forEach(variants[0].evidenceCounts, function (value, key) {
-            values.push(key + ": " + value);
-        });
-    }
-    // this indicates that we have an entry but the evidence is empty
-    if (values.length === 0) {
-        return CIVIC_NA_VALUE;
-    }
-    return values.join(', ');
-}
-var Civic = /** @class */ (function (_super) {
-    __extends(Civic, _super);
-    function Civic(props) {
-        var _this = _super.call(this, props) || this;
-        Object.defineProperty(_this, "tooltipDataLoadComplete", {
-            enumerable: true,
-            configurable: true,
-            writable: true,
-            value: false
-        });
-        makeObservable(_this);
-        _this.cardContent = _this.cardContent.bind(_this);
-        return _this;
-    }
-    Object.defineProperty(Civic.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var civicContent = (React.createElement("span", { className: "" + annotationStyles['annotation-item'] }));
-            var civicImgWidth = 14;
-            var civicImgHeight = 14;
-            var civicImgSrc = !this.props.hasCivicVariants
-                ? img$3
-                : img$4;
-            if (this.props.civicStatus == 'error') {
-                civicContent = errorIcon('Error fetching Civic data');
-            }
-            else if (this.props.civicEntry !== undefined) {
-                if (this.props.civicEntry !== null &&
-                    this.props.civicStatus == 'complete') {
-                    civicContent = (React.createElement("span", { className: "" + annotationStyles['annotation-item'] },
-                        React.createElement("img", { width: civicImgWidth, height: civicImgHeight, src: civicImgSrc, alt: "Civic Variant Entry" })));
-                    civicContent = (React.createElement(DefaultTooltip, { overlay: this.cardContent.bind(this, this.props.civicEntry), placement: "right", trigger: ['hover', 'focus'], onPopupAlign: hideArrow$1, destroyTooltipOnHide: false }, civicContent));
-                }
-            }
-            else {
-                // It's still unknown (undefined) if the current gene has a Civic entry or not.
-                civicContent = loaderIcon('pull-left');
-            }
-            return civicContent;
-        }
-    });
-    Object.defineProperty(Civic.prototype, "cardContent", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function (civicEntry) {
-            return (React.createElement(CivicCard, { title: "CIViC Variants", geneName: civicEntry.name, geneDescription: civicEntry.description, geneUrl: civicEntry.url, variants: civicEntry.variants }));
-        }
-    });
-    __decorate([
-        observable
-    ], Civic.prototype, "tooltipDataLoadComplete", void 0);
-    Civic = __decorate([
-        observer
-    ], Civic);
-    return Civic;
-}(React.Component));
-
-var NoClinvarData = function () {
-    return (React.createElement(DefaultTooltip, { placement: "topLeft", overlay: React.createElement("span", null, "Variant has no ClinVar data.") },
-        React.createElement("span", { style: {
-                height: '100%',
-                width: '100%',
-                display: 'block',
-                overflow: 'hidden',
-            } }, "\u00A0")));
-};
-var ClinvarSummary = function (props) {
-    if (!props.clinvar) {
-        return React.createElement(NoClinvarData, null);
-    }
-    else {
-        var clinvarId = props.clinvar.clinvarId;
-        var clinvarLink = "https://www.ncbi.nlm.nih.gov/clinvar/variation/" + clinvarId + "/";
-        var clinicalSignificance = props.clinvar.clinicalSignificance;
-        var conflictingClinicalSignificance = props.clinvar.conflictingClinicalSignificance;
-        return (React.createElement(TruncatedText, { maxLength: 30, text: clinicalSignificance, addTooltip: "always", tooltip: React.createElement("div", { style: { maxWidth: 300 } },
-                React.createElement("div", null, clinicalSignificance),
-                conflictingClinicalSignificance && (React.createElement("div", null, conflictingClinicalSignificance)),
-                React.createElement("div", null,
-                    "(ClinVar ID:",
-                    ' ',
-                    React.createElement("a", { href: clinvarLink, target: "_blank" }, clinvarId),
-                    ")")) }));
-    }
-};
-
-// oncogenic value => score
-// (used for sorting purposes)
-var ONCOGENIC_SCORE = {
-    Unknown: 0,
-    Inconclusive: 0,
-    'Likely Neutral': 0,
-    Resistance: 5,
-    'Likely Oncogenic': 5,
-    Oncogenic: 5,
-};
-// sensitivity level => score
-// (used for sorting purposes)
-var SENSITIVITY_LEVEL_SCORE = {
-    '4': 1,
-    '3B': 2,
-    '3A': 3,
-    '2': 5,
-    '1': 6,
-};
-// resistance level <-> score
-// (used for sorting purposes)
-var RESISTANCE_LEVEL_SCORE = {
-    R3: 1,
-    R2: 2,
-    R1: 3,
-};
-// diagnostic level <-> score
-// (used for sorting purposes)
-var DIAGNOSTIC_LEVEL_SCORE = {
-    Dx3: 1,
-    Dx2: 2,
-    Dx1: 3,
-};
-// prognostic level <-> score
-// (used for sorting purposes)
-var PROGNOSTIC_LEVEL_SCORE = {
-    Px3: 1,
-    Px2: 2,
-    Px1: 3,
-};
-function normalizeLevel(level) {
-    if (level) {
-        var matchArray = level.match(/LEVEL_(.*)/);
-        if (matchArray && matchArray.length >= 2) {
-            return matchArray[1];
-        }
-        else {
-            return level;
-        }
-    }
-    else {
-        return null;
-    }
-}
-function normalizeOncogenicity(oncogenicity) {
-    return (oncogenicity || 'unknown')
-        .trim()
-        .toLowerCase()
-        .replace(/\s/, '-');
-}
-function levelIconClassNames(level) {
-    if (level) {
-        return "oncokb icon level-" + level;
-    }
-    return '';
-}
-function oncogenicityIconClassNames(oncogenicity) {
-    return "oncokb icon " + normalizeOncogenicity(oncogenicity);
-}
-function annotationIconClassNames(type, highestLevel, indicator) {
-    return type === OncoKbCardDataType.BIOLOGICAL
-        ? oncogenicityIconClassNames((indicator === null || indicator === void 0 ? void 0 : indicator.oncogenic) || '')
-        : levelIconClassNames(normalizeLevel(highestLevel) || '');
-}
-function calcHighestIndicatorLevel(type, indicator) {
-    var highestLevel = '';
-    if (indicator) {
-        switch (type) {
-            case OncoKbCardDataType.TXS:
-                highestLevel = indicator.highestSensitiveLevel;
-                break;
-            case OncoKbCardDataType.TXR:
-                highestLevel = indicator.highestResistanceLevel;
-                break;
-            case OncoKbCardDataType.DX:
-                highestLevel = indicator.highestDiagnosticImplicationLevel;
-                break;
-            case OncoKbCardDataType.PX:
-                highestLevel = indicator.highestPrognosticImplicationLevel;
-                break;
-        }
-    }
-    return highestLevel;
-}
-function calcOncogenicScore(oncogenic) {
-    return ONCOGENIC_SCORE[oncogenic] || 0;
-}
-function calcSensitivityLevelScore(level) {
-    return SENSITIVITY_LEVEL_SCORE[normalizeLevel(level) || ''] || 0;
-}
-function calcResistanceLevelScore(level) {
-    return RESISTANCE_LEVEL_SCORE[normalizeLevel(level) || ''] || 0;
-}
-function calcDiagnosticLevelScore(level) {
-    return DIAGNOSTIC_LEVEL_SCORE[normalizeLevel(level) || ''] || 0;
-}
-function calcPrognosticLevelScore(level) {
-    return PROGNOSTIC_LEVEL_SCORE[normalizeLevel(level) || ''] || 0;
-}
-/**
- * Return combined alterations name, separated by comma.
- * Same location variant will be truncated into AALocationAllele e.g. V600E/K
- *
- * @param {Array} alterations - List of alterations
- * @return {string} - Truncated alteration name
- */
-function mergeAlterations(alterations) {
-    var positions = {};
-    var regular = [];
-    var regExp = new RegExp('^([A-Z])([0-9]+)([A-Z]$)');
-    if (___default.isString(alterations)) {
-        return alterations;
-    }
-    ___default.each(alterations, function (alteration) {
-        var result = regExp.exec(alteration);
-        if (___default.isArray(result) && result.length === 4) {
-            if (!positions.hasOwnProperty(result[2])) {
-                positions[result[2]] = {};
-            }
-            if (!positions[result[2]].hasOwnProperty(result[1])) {
-                // Avoid duplication, use object instead of array
-                positions[result[2]][result[1]] = {};
-            }
-            positions[result[2]][result[1]][result[3]] = 1;
-        }
-        else {
-            regular.push(alteration);
-        }
-    });
-    ___default.each(___default.keys(positions)
-        .map(function (e) {
-        return Number(e);
-    })
-        .sort(), function (position) {
-        ___default.each(___default.keys(positions[position]).sort(), function (aa) {
-            regular.push(aa +
-                position +
-                ___default.keys(positions[position][aa])
-                    .sort()
-                    .join('/'));
-        });
-    });
-    return regular.join(', ');
-}
-/**
- * Return the positional variant of the missense mutation
- * @param alteration The missense mutation
- */
-function getPositionalVariant(alteration) {
-    var regExp = new RegExp('^([A-Z]+)([0-9]+)([A-Z]*)$');
-    var result = regExp.exec(alteration);
-    // Only if the alteration is missense mutation or positional variant
-    // result[0]: matched alteration
-    // result[1]: reference alleles (there could be multiple reference alleles, we only return the first allele)
-    // result[2]: position(protein start/end)
-    // result[3]: variant alleles (empty if the alteration is positional variant already)
-    if (___default.isArray(result) &&
-        result.length === 4 &&
-        (!result[3] || result[1].length === result[3].length)) {
-        return "" + result[1][0] + result[2];
-    }
-    return undefined;
-}
-function getTumorTypeName(tumorType) {
-    if (!tumorType) {
-        return '';
-    }
-    else if (tumorType.name) {
-        return tumorType.name;
-    }
-    else if (tumorType.mainType) {
-        return tumorType.mainType.name;
-    }
-    else {
-        return '';
-    }
-}
-function getTumorTypeNameWithExclusionInfo(tumorType, excludedTumorTypes) {
-    var name = getTumorTypeName(tumorType);
-    if (!___default.isEmpty(excludedTumorTypes)) {
-        name = name + " (excluding " + excludedTumorTypes
-            .map(function (ett) { return getTumorTypeName(ett); })
-            .join(', ') + ")";
-    }
-    return name;
-}
-function groupOncoKbIndicatorDataByMutations(mutationsByPosition, oncoKbData, getTumorType, getEntrezGeneId, filter) {
-    var indicatorMap = {};
-    ___default.keys(mutationsByPosition).forEach(function (key) {
-        var position = Number(key);
-        var indicators = mutationsByPosition[position]
-            .map(function (mutation) {
-            return getIndicatorData(mutation, oncoKbData, getTumorType, getEntrezGeneId);
-        })
-            .filter(function (indicator) {
-            return indicator !== undefined && (!filter || filter(indicator));
-        });
-        if (position > 0 && indicators.length > 0) {
-            indicatorMap[position] = indicators;
-        }
-    });
-    return indicatorMap;
-}
-function getIndicatorData(mutation, oncoKbData, getTumorType, getEntrezGeneId) {
-    if (oncoKbData.indicatorMap === null) {
-        return undefined;
-    }
-    var id = '';
-    // @ts-ignore
-    var sv = mutation.structuralVariant;
-    if (sv) {
-        var structuralVariantType = deriveStructuralVariantType(sv);
-        id = generateQueryStructuralVariantId(sv.site1EntrezGeneId, sv.site2EntrezGeneId, getTumorType(mutation), structuralVariantType);
-    }
-    else {
-        id = generateQueryVariantId(getEntrezGeneId(mutation), getTumorType(mutation), mutation.proteinChange, mutation.mutationType);
-    }
-    return oncoKbData.indicatorMap[id];
-}
-function defaultOncoKbIndicatorFilter(indicator) {
-    return indicator.oncogenic
-        .toLowerCase()
-        .trim()
-        .includes('oncogenic');
-}
-function defaultOncoKbFilter(mutation, oncoKbData, getTumorType, getEntrezGeneId) {
-    var filter = true;
-    if (oncoKbData && getTumorType && getEntrezGeneId) {
-        var indicatorData = getIndicatorData(mutation, oncoKbData, getTumorType, getEntrezGeneId);
-        filter = indicatorData
-            ? defaultOncoKbIndicatorFilter(indicatorData)
-            : false;
-    }
-    return filter;
-}
-
-var img$2 = "data:image/png;base64,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";
-
-var mcgStyles = {"link-list":"myCancerGenome-module_link-list__2wFhH"};
-
-function placeArrow$1(tooltipEl) {
-    var arrowEl = tooltipEl.querySelector('.rc-tooltip-arrow');
-    arrowEl.style.left = '10px';
-}
-function sortValue$7(links) {
-    return links.length > 0 ? 1 : 0;
-}
-function download$6(links) {
-    return links.length > 0 ? 'present' : 'not present';
-}
-function myCancerGenomeLinks(linksHTML) {
-    var links = [];
-    ___default.each(linksHTML, function (link, index) {
-        // TODO this is a workaround, ideally we should fix the data itself
-        // parse the data as an HTML dom element, since it is formatted as an HTML link.
-        var myCancerGenomeLink = parseMyCancerGenomeLink(link);
-        if (myCancerGenomeLink) {
-            links.push(React.createElement("li", { key: index },
-                React.createElement("a", { href: myCancerGenomeLink.url, target: "_blank" }, myCancerGenomeLink.text)));
-        }
-    });
-    return (React.createElement("span", null,
-        React.createElement("b", null, "My Cancer Genome links:"),
-        React.createElement("br", null),
-        React.createElement("ul", { className: mcgStyles['link-list'] }, links)));
-}
-var MyCancerGenome = /** @class */ (function (_super) {
-    __extends(MyCancerGenome, _super);
-    function MyCancerGenome() {
-        return _super !== null && _super.apply(this, arguments) || this;
-    }
-    Object.defineProperty(MyCancerGenome.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var myCancerGenomeContent = (React.createElement("span", { className: "" + annotationStyles['annotation-item'] }));
-            if (this.props.linksHTML.length > 0) {
-                var arrowContent = React.createElement("div", { className: "rc-tooltip-arrow-inner" });
-                var tooltipContent = myCancerGenomeLinks(this.props.linksHTML);
-                myCancerGenomeContent = (React.createElement(DefaultTooltip, { overlay: tooltipContent, placement: "topLeft", trigger: ['hover', 'focus'], arrowContent: arrowContent, onPopupAlign: placeArrow$1 },
-                    React.createElement("span", { className: annotationStyles['annotation-item'] + " mcg" },
-                        React.createElement("img", { width: "14", height: "14", src: img$2, alt: "My Cancer Genome Symbol" }))));
-            }
-            return myCancerGenomeContent;
-        }
-    });
-    return MyCancerGenome;
-}(React.Component));
-
-function hideArrow(tooltipEl) {
-    var arrowEl = tooltipEl.querySelector('.rc-tooltip-arrow');
-    arrowEl.style.display = 'none';
-}
-var AnnotationIcon = function (props) {
-    if (props.availableDataTypes !== undefined &&
-        !props.availableDataTypes.includes(props.type)) {
-        return null;
-    }
-    var highestLevel = calcHighestIndicatorLevel(props.type, props.indicator);
-    return (React__default.createElement(AnnotationIconWithTooltip, { tooltipOverlay: props.tooltipOverlay, icon: React__default.createElement("i", { className: annotationIconClassNames(props.type, highestLevel, props.indicator), "data-test": "oncogenic-icon-image" }) }));
-};
-var AnnotationIconWithTooltip = function (props) {
-    if (props.icon) {
-        return (React__default.createElement(DefaultTooltip, { overlayClassName: "oncokb-tooltip", overlay: function () {
-                return props.tooltipOverlay ? props.tooltipOverlay : null;
-            }, placement: "right", trigger: ['hover', 'focus'], onPopupAlign: hideArrow, destroyTooltipOnHide: true },
-            React__default.createElement("span", { className: "" + annotationStyles['annotation-item'] }, props.icon)));
-    }
-    else {
-        return null;
-    }
-};
-
-var BIOLOGICAL_COLOR_MAP = {
-    oncogenic: '#0968C3',
-    'likely-oncogenic': '#0968C3',
-    resistance: '#0968C3',
-    neutral: '#696969',
-    'likely-neutral': '#696969',
-    inconclusive: '#AAAAAA',
-    vus: '#696969',
-    unknown: '#CCCCCC',
-};
-var LEVEL_COLOR_MAP = {
-    '1': '#33A02C',
-    '2': '#1F78B4',
-    '3': '#984EA3',
-    '3A': '#984EA3',
-    '3B': '#BE98CE',
-    '4': '#424242',
-    R1: '#EE3424',
-    R2: '#F79A92',
-    R3: '#FCD6D3',
-    Dx1: '#33A02C',
-    Dx2: '#1F78B4',
-    Dx3: '#984EA3',
-    Px1: '#33A02C',
-    Px2: '#1F78B4',
-    Px3: '#984EA3',
-};
-function getLevelColor(highestLevel, defaultColor) {
-    if (defaultColor === void 0) { defaultColor = '#CCCCCC'; }
-    var level = normalizeLevel(highestLevel || null) || '';
-    return LEVEL_COLOR_MAP[level] || defaultColor;
-}
-function shouldDrawShape(type, level, availableDataTypes) {
-    return (level &&
-        availableDataTypes !== undefined &&
-        availableDataTypes.includes(type));
-}
-function getOncogenicShape(indicator) {
-    var oncogenicity = normalizeOncogenicity((indicator === null || indicator === void 0 ? void 0 : indicator.oncogenic) || '');
-    var color = BIOLOGICAL_COLOR_MAP[oncogenicity] || '#CCCCCC';
-    return (React__default.createElement("g", { transform: "translate(9, 9)" },
-        React__default.createElement("circle", { r: "6", fill: "none", strokeWidth: "2", stroke: color }),
-        oncogenicity !== 'vus' && oncogenicity !== 'unknown' && (React__default.createElement("g", null,
-            React__default.createElement("circle", { r: "3", fill: "none", strokeWidth: "2", stroke: color }),
-            React__default.createElement("circle", { r: "1.5", fill: color, stroke: "none" })))));
-}
-function getTherapeuticSensitivityShape(indicator, availableDataTypes) {
-    var highestLevel = indicator === null || indicator === void 0 ? void 0 : indicator.highestSensitiveLevel;
-    if (!shouldDrawShape(OncoKbCardDataType.TXS, highestLevel, availableDataTypes)) {
-        return null;
-    }
-    var fillColor = getLevelColor(highestLevel, '#33A02C');
-    return (React__default.createElement("g", { transform: "translate(14.5, 3.5)" },
-        React__default.createElement("circle", { r: "4", fill: fillColor, stroke: "#ffffff", strokeWidth: "1" })));
-}
-function getTherapeuticResistanceShape(indicator, availableDataTypes) {
-    var highestLevel = indicator === null || indicator === void 0 ? void 0 : indicator.highestResistanceLevel;
-    if (!shouldDrawShape(OncoKbCardDataType.TXR, highestLevel, availableDataTypes)) {
-        return null;
-    }
-    var fillColor = getLevelColor(highestLevel, '#EE3424');
-    return (React__default.createElement("g", { transform: "translate(14.5, 14.5)" },
-        React__default.createElement("circle", { r: "4", fill: fillColor, stroke: "#ffffff", strokeWidth: "1" })));
-}
-function getDiagnosticShape(indicator, availableDataTypes) {
-    var highestLevel = indicator === null || indicator === void 0 ? void 0 : indicator.highestDiagnosticImplicationLevel;
-    if (!shouldDrawShape(OncoKbCardDataType.DX, highestLevel, availableDataTypes)) {
-        return null;
-    }
-    var fillColor = getLevelColor(highestLevel, '#33A02C');
-    return (React__default.createElement("g", { transform: "translate(-0.5, -0.5)" },
-        React__default.createElement("rect", { width: "7", height: "7", fill: fillColor, stroke: "#ffffff", strokeWidth: "1" })));
-}
-function getPrognosticShape(indicator, availableDataTypes) {
-    var highestLevel = indicator === null || indicator === void 0 ? void 0 : indicator.highestPrognosticImplicationLevel;
-    if (!shouldDrawShape(OncoKbCardDataType.PX, highestLevel, availableDataTypes)) {
-        return null;
-    }
-    var fillColor = getLevelColor(highestLevel, '#33A02C');
-    return (React__default.createElement("g", { transform: "translate(0, 10.5)" },
-        React__default.createElement("polygon", { points: "3.5 0, 8 8, -1 8", fill: fillColor, stroke: "#ffffff", strokeWidth: "1" })));
-}
-var CompactAnnotationIcon = function (props) {
-    var indicatorForLevelIcons = props.usingPublicOncoKbInstance
-        ? undefined
-        : props.indicator;
-    return (React__default.createElement("svg", { version: "1.1", width: "18", height: "18", "data-test": "oncogenic-icon-image" },
-        getOncogenicShape(props.indicator),
-        getTherapeuticSensitivityShape(indicatorForLevelIcons, props.availableDataTypes),
-        getTherapeuticResistanceShape(indicatorForLevelIcons, props.availableDataTypes),
-        getDiagnosticShape(indicatorForLevelIcons, props.availableDataTypes),
-        getPrognosticShape(indicatorForLevelIcons, props.availableDataTypes)));
-};
-
-var mainStyles = {"oncokb-card":"main-module_oncokb-card__32DzD","tab-content":"main-module_tab-content__8nUyf","tooltip-refs":"main-module_tooltip-refs__SpA4W","disclaimer":"main-module_disclaimer__3CLlM","blue-icon":"main-module_blue-icon__2Hs-v","footer":"main-module_footer__2dc-8","oncokb-logo":"main-module_oncokb-logo__3RVg7","title":"main-module_title__2kT-n","additional-info":"main-module_additional-info__1nXTm","biological-info":"main-module_biological-info__2efDC","ellipsis-text-wrapper":"main-module_ellipsis-text-wrapper__18dny"};
-
-var _a$4;
-var OtherBiomarkersQueryType;
-(function (OtherBiomarkersQueryType) {
-    OtherBiomarkersQueryType["MSIH"] = "MSIH";
-    OtherBiomarkersQueryType["TMBH"] = "TMBI";
-})(OtherBiomarkersQueryType || (OtherBiomarkersQueryType = {}));
-var OTHER_BIOMARKER_HUGO_SYMBOL = 'Other Biomarkers';
-var MSI_H_NAME = 'MSI-H';
-var TMB_H_NAME = 'TMB-H';
-var OTHER_BIOMARKER_NAME = (_a$4 = {},
-    _a$4[OtherBiomarkersQueryType.MSIH] = MSI_H_NAME,
-    _a$4[OtherBiomarkersQueryType.TMBH] = TMB_H_NAME,
-    _a$4);
-
-var OncoKbCardTitle = function (props) {
-    var titleContent = [];
-    if (props.hugoSymbol &&
-        props.hugoSymbol !== OTHER_BIOMARKER_HUGO_SYMBOL &&
-        (!props.variant || !props.variant.includes(props.hugoSymbol))) {
-        titleContent.push(props.hugoSymbol);
-    }
-    if (props.variant) {
-        titleContent.push(props.variant);
-    }
-    if (props.tumorType) {
-        if (titleContent.length > 0) {
-            titleContent.push('in');
-        }
-        titleContent.push(props.tumorType);
-    }
-    return (React.createElement("div", { className: mainStyles['title'], "data-test": "oncokb-card-title" }, React.createElement("span", null, titleContent.join(' '))));
-};
-
-var levelStyles = {"levels":"level-module_levels__2ZL1B","levels-li":"level-module_levels-li__1tgCC"};
-
-var collapsibleStyles = {"collapsible-header":"collapsible-module_collapsible-header__3nZtU","levels-collapse":"collapsible-module_levels-collapse__2GBRW"};
-
-var OncoKbCardLevelsOfEvidenceDropdown = /** @class */ (function (_super) {
-    __extends(OncoKbCardLevelsOfEvidenceDropdown, _super);
-    function OncoKbCardLevelsOfEvidenceDropdown(props) {
-        var _this = _super.call(this, props) || this;
-        Object.defineProperty(_this, "levelsCollapsed", {
-            enumerable: true,
-            configurable: true,
-            writable: true,
-            value: true
-        });
-        makeObservable(_this);
-        return _this;
-    }
-    Object.defineProperty(OncoKbCardLevelsOfEvidenceDropdown.prototype, "levelListItem", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function (level, levelDes) {
-            return (React__default.createElement("li", { key: level, className: levelStyles['levels-li'] },
-                React__default.createElement("i", { className: levelIconClassNames(level) }),
-                levelDes));
-        }
-    });
-    Object.defineProperty(OncoKbCardLevelsOfEvidenceDropdown.prototype, "generateLevelRows", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var _this = this;
-            var rows = [];
-            this.props.levels.forEach(function (level) {
-                rows.push(_this.levelListItem(level, _this.props.levelDes[level]));
-            });
-            return rows;
-        }
-    });
-    Object.defineProperty(OncoKbCardLevelsOfEvidenceDropdown.prototype, "handleLevelCollapse", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            this.levelsCollapsed = !this.levelsCollapsed;
-        }
-    });
-    Object.defineProperty(OncoKbCardLevelsOfEvidenceDropdown.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            return (React__default.createElement("div", null,
-                React__default.createElement("div", { "data-test": "oncokb-card-levels-of-evidence-dropdown-header", className: collapsibleStyles['collapsible-header'], onClick: this.handleLevelCollapse },
-                    "Levels of Evidence",
-                    React__default.createElement("span", { style: { float: 'right' } }, this.levelsCollapsed ? (React__default.createElement("i", { className: classnames('fa fa-chevron-down', mainStyles['blue-icon']) })) : (React__default.createElement("i", { className: classnames('fa fa-chevron-up', mainStyles['blue-icon']) })))),
-                React__default.createElement(Collapse, { isOpened: !this.levelsCollapsed },
-                    React__default.createElement("div", { className: classnames(levelStyles.levels, collapsibleStyles['levels-collapse']) },
-                        React__default.createElement("ul", { style: {
-                                lineHeight: 8,
-                                padding: 0,
-                            } }, this.generateLevelRows())))));
-        }
-    });
-    __decorate([
-        observable
-    ], OncoKbCardLevelsOfEvidenceDropdown.prototype, "levelsCollapsed", void 0);
-    __decorate([
-        action.bound
-    ], OncoKbCardLevelsOfEvidenceDropdown.prototype, "handleLevelCollapse", null);
-    OncoKbCardLevelsOfEvidenceDropdown = __decorate([
-        observer
-    ], OncoKbCardLevelsOfEvidenceDropdown);
-    return OncoKbCardLevelsOfEvidenceDropdown;
-}(React__default.Component));
-
-var OncoKBSuggestAnnotationLinkout = /** @class */ (function (_super) {
-    __extends(OncoKBSuggestAnnotationLinkout, _super);
-    function OncoKBSuggestAnnotationLinkout() {
-        return _super !== null && _super.apply(this, arguments) || this;
-    }
-    Object.defineProperty(OncoKBSuggestAnnotationLinkout.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            return (React.createElement("div", null,
-                React.createElement("span", null, "The gene is listed under "),
-                React.createElement("a", { href: "https://www.oncokb.org/cancerGenes", target: "_blank" }, "OncoKB Cancer Gene List"),
-                React.createElement("span", null, " but hasn't been curated yet. Please feel free to "),
-                React.createElement("a", { target: "_blank", href: "mailto:contact@oncokb.org?subject=Annotation suggestion for " + this.props.gene + "&&body=Thank you for using OncoKB\u2122.%0APlease provide the following information for " + this.props.gene + " curation:%0A%0AEvidence:%0APMIDs:%0AAbstracts:", title: "suggest to annotate this gene" }, "suggest the team annotate the gene"),
-                "."));
-        }
-    });
-    return OncoKBSuggestAnnotationLinkout;
-}(React.Component));
-
-var levelTooltipContent = function (level) {
-    return (React.createElement("div", { style: { maxWidth: '200px' } }, OncoKbHelper.LEVEL_DESC[level]));
-};
-var LevelIcon = function (props) {
-    return (React.createElement(DefaultTooltip, { overlay: levelTooltipContent(props.level), placement: "left", disabled: !props.showDescription, trigger: ['hover', 'focus'], destroyTooltipOnHide: true },
-        React.createElement("i", { className: levelIconClassNames(props.level) })));
-};
-
-var OncoKbHelper = /** @class */ (function () {
-    function OncoKbHelper() {
-    }
-    Object.defineProperty(OncoKbHelper, "TX_LEVELS", {
-        get: function () {
-            return ['1', '2', '3A', '3B', '4', 'R1', 'R2'];
-        },
-        enumerable: false,
-        configurable: true
-    });
-    Object.defineProperty(OncoKbHelper, "DX_LEVELS", {
-        get: function () {
-            return ['Dx1', 'Dx2', 'Dx3'];
-        },
-        enumerable: false,
-        configurable: true
-    });
-    Object.defineProperty(OncoKbHelper, "PX_LEVELS", {
-        get: function () {
-            return ['Px1', 'Px2', 'Px3'];
-        },
-        enumerable: false,
-        configurable: true
-    });
-    Object.defineProperty(OncoKbHelper, "LEVELS", {
-        get: function () {
-            return __spreadArrays(this.TX_LEVELS, this.DX_LEVELS, this.PX_LEVELS);
-        },
-        enumerable: false,
-        configurable: true
-    });
-    Object.defineProperty(OncoKbHelper, "getLevelsDesc", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function (dataType) {
-            switch (dataType) {
-                case OncoKbCardDataType.TXS:
-                case OncoKbCardDataType.TXR:
-                    return ___default.pick(this.LEVEL_DESC, this.TX_LEVELS);
-                case OncoKbCardDataType.DX:
-                    return ___default.pick(this.LEVEL_DESC, this.DX_LEVELS);
-                case OncoKbCardDataType.PX:
-                    return ___default.pick(this.LEVEL_DESC, this.PX_LEVELS);
-                default:
-                    return {};
-            }
-        }
-    });
-    Object.defineProperty(OncoKbHelper, "LEVEL_DESC", {
-        get: function () {
-            return {
-                '1': (React.createElement("span", null,
-                    React.createElement("b", null, "FDA-recognized"),
-                    " biomarker predictive of response to an",
-                    ' ',
-                    React.createElement("b", null, "FDA-approved drug"),
-                    " in this indication")),
-                '2': (React.createElement("span", null,
-                    React.createElement("b", null, "Standard care"),
-                    " biomarker recommended by the NCCN or other expert panels predictive of response to an",
-                    ' ',
-                    React.createElement("b", null, "FDA-approved drug"),
-                    " in this indication")),
-                '3A': (React.createElement("span", null,
-                    React.createElement("b", null, "Compelling clinical evidence"),
-                    " supports the biomarker as being predictive of response to a drug in this indication")),
-                '3B': (React.createElement("span", null,
-                    React.createElement("b", null, "Standard care"),
-                    " or ",
-                    React.createElement("b", null, "investigational"),
-                    " biomarker",
-                    ' ',
-                    "predictive of response to an ",
-                    React.createElement("b", null, "FDA-approved"),
-                    " or",
-                    ' ',
-                    React.createElement("b", null, "investigational"),
-                    " drug in another indication")),
-                '4': (React.createElement("span", null,
-                    React.createElement("b", null, "Compelling biological evidence"),
-                    " supports the biomarker as being predictive of response to a drug")),
-                R1: (React.createElement("span", null,
-                    React.createElement("b", null, "Standard care"),
-                    " biomarker predictive of",
-                    ' ',
-                    React.createElement("b", null, "resistance"),
-                    " to an ",
-                    React.createElement("b", null, "FDA-approved"),
-                    " drug",
-                    ' ',
-                    React.createElement("b", null, "in this indication"))),
-                R2: (React.createElement("span", null,
-                    React.createElement("b", null, "Compelling clinical evidence"),
-                    " supports the biomarker as being predictive of ",
-                    React.createElement("b", null, "resistance"),
-                    " to a drug")),
-                Dx1: (React.createElement("span", null,
-                    React.createElement("b", null, "FDA and/or professional guideline-recognized"),
-                    ' ',
-                    "biomarker required for diagnosis in this indication")),
-                Dx2: (React.createElement("span", null,
-                    React.createElement("b", null, "FDA and/or professional guideline-recognized"),
-                    ' ',
-                    "biomarker that supports diagnosis in this indication")),
-                Dx3: (React.createElement("span", null,
-                    "Biomarker that ",
-                    React.createElement("b", null, "may assist disease diagnosis"),
-                    " in this indication based on ",
-                    React.createElement("b", null, "clinical evidence"))),
-                Px1: (React.createElement("span", null,
-                    React.createElement("b", null, "FDA and/or professional guideline-recognized"),
-                    ' ',
-                    "biomarker prognostic in this indication based on",
-                    ' ',
-                    React.createElement("b", null, "well-powered studie(s)"))),
-                Px2: (React.createElement("span", null,
-                    React.createElement("b", null, "FDA and/or professional guideline-recognized"),
-                    ' ',
-                    "biomarker prognostic in this indication based on",
-                    ' ',
-                    React.createElement("b", null, "a single or multiple small studies"))),
-                Px3: (React.createElement("span", null,
-                    "Biomarker is prognostic in this indication based on",
-                    ' ',
-                    React.createElement("b", null, "clinical evidence"),
-                    " in ",
-                    React.createElement("b", null, "well-powered studies"))),
-            };
-        },
-        enumerable: false,
-        configurable: true
-    });
-    Object.defineProperty(OncoKbHelper, "getDefaultColumnDefinition", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function (columnKey) {
-            switch (columnKey) {
-                case 'level':
-                    return {
-                        id: 'level',
-                        Header: React.createElement("div", { style: { textAlign: 'center' } }, "Level"),
-                        accessor: 'level',
-                        maxWidth: 45,
-                        sortMethod: function (a, b) {
-                            return defaultSortMethod(LEVELS.all.indexOf(normalizeLevel(a) || ''), LEVELS.all.indexOf(normalizeLevel(b) || ''));
-                        },
-                        Cell: function (props) {
-                            var normalizedLevel = normalizeLevel(props.value) || '';
-                            return (React.createElement(LevelIcon, { level: normalizedLevel, showDescription: true }));
-                        },
-                    };
-                case 'alterations':
-                    return {
-                        id: 'alterations',
-                        Header: React.createElement("span", null, "Alteration(s)"),
-                        accessor: 'alterations',
-                        minWidth: 80,
-                        sortMethod: function (a, b) {
-                            return defaultArraySortMethod(a, b);
-                        },
-                    };
-            }
-        }
-    });
-    Object.defineProperty(OncoKbHelper, "getAlterationsColumnCell", {
-        enumerable: true,
-        configurable: true,
-        writable: true,
-        value: function (alterations, variant) {
-            var mergedAlteration = mergeAlterations(alterations);
-            var content = React.createElement("span", null, mergedAlteration);
-            if (alterations.length > 5) {
-                var lowerCasedQueryVariant_1 = variant.toLowerCase();
-                var matchedAlteration = ___default.find(alterations, function (alteration) {
-                    return alteration.toLocaleLowerCase() === lowerCasedQueryVariant_1;
-                });
-                if (!matchedAlteration) {
-                    matchedAlteration = getPositionalVariant(variant);
-                }
-                var pickedAlteration = matchedAlteration === undefined
-                    ? alterations[0]
-                    : matchedAlteration;
-                content = (React.createElement("span", null,
-                    pickedAlteration,
-                    " and",
-                    ' ',
-                    React.createElement(DefaultTooltip, { overlay: React.createElement("div", { style: { maxWidth: '400px' } }, mergedAlteration), placement: "right", destroyTooltipOnHide: true },
-                        React.createElement("a", null,
-                            alterations.length - 1,
-                            " other alterations"))));
-            }
-            return (React.createElement("div", { style: { whiteSpace: 'normal', lineHeight: '1rem' } }, content));
-        }
-    });
-    return OncoKbHelper;
-}());
-
-var styles$a = {"list-group-item":"listGroupItem-module_list-group-item__1Y5zb","list-group-item-title":"listGroupItem-module_list-group-item-title__3diZg","list-group-item-content":"listGroupItem-module_list-group-item-content__Sspft","no-style-ul":"listGroupItem-module_no-style-ul__2Rf8i"};
-
-var ArticleAbstractItem = /** @class */ (function (_super) {
-    __extends(ArticleAbstractItem, _super);
-    function ArticleAbstractItem() {
-        return _super !== null && _super.apply(this, arguments) || this;
-    }
-    Object.defineProperty(ArticleAbstractItem.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var content = React.createElement("span", null, this.props.abstract);
-            if (this.props.link) {
-                content = (React.createElement("a", { href: this.props.link, target: "_blank" }, content));
-            }
-            return (React.createElement("li", { key: "abstract_" + this.props.abstract, className: styles$a['list-group-item'] },
-                React.createElement("span", { className: styles$a['list-group-item-title'] }, content)));
-        }
-    });
-    return ArticleAbstractItem;
-}(React.Component));
-
-var PmidItem = /** @class */ (function (_super) {
-    __extends(PmidItem, _super);
-    function PmidItem() {
-        return _super !== null && _super.apply(this, arguments) || this;
-    }
-    Object.defineProperty(PmidItem.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            return (React.createElement("li", { key: this.props.pmid, className: styles$a['list-group-item'] },
-                React.createElement("a", { className: styles$a['list-group-item-title'], href: getNCBIlink("/pubmed/" + this.props.pmid), target: "_blank" },
-                    React.createElement("span", null, trimOffHtmlTagEntities(this.props.title))),
-                React.createElement("div", { className: styles$a['list-group-item-content'] },
-                    React.createElement("span", null,
-                        this.props.author,
-                        " ",
-                        this.props.source,
-                        ".",
-                        ' ',
-                        this.props.date),
-                    React.createElement("span", null,
-                        "PMID: ",
-                        this.props.pmid))));
-        }
-    });
-    return PmidItem;
-}(React.Component));
-
-var ReferenceList = /** @class */ (function (_super) {
-    __extends(ReferenceList, _super);
-    function ReferenceList() {
-        return _super !== null && _super.apply(this, arguments) || this;
-    }
-    Object.defineProperty(ReferenceList.prototype, "isLoading", {
-        get: function () {
-            var _this = this;
-            if (this.props.pmidData && this.props.pmids) {
-                var loadingItems = ___default.filter(this.props.pmids, function (uid) {
-                    var cacheData = _this.props.pmidData[uid.toString()];
-                    // when the cacheData is undefined, the pmidData will fetch the uid info later which eventually results to an object with a status
-                    return !cacheData || cacheData.status === 'pending';
-                });
-                return loadingItems.length > 0;
-            }
-            else {
-                return false;
-            }
-        },
-        enumerable: false,
-        configurable: true
-    });
-    Object.defineProperty(ReferenceList.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var _this = this;
-            if (this.isLoading) {
-                return React.createElement("i", { className: "fa fa-spinner fa-pulse fa-2x" });
-            }
-            var list = [];
-            if (this.props.pmidData) {
-                this.props.pmids.forEach(function (uid) {
-                    var cacheData = _this.props.pmidData[uid.toString()];
-                    var articleContent = cacheData ? cacheData.data : null;
-                    if (articleContent) {
-                        list.push(React.createElement(PmidItem, { title: articleContent.title, author: ___default.isArray(articleContent.authors) &&
-                                articleContent.authors.length > 0
-                                ? articleContent.authors[0].name + ' et al.'
-                                : 'Unknown', source: articleContent.source, date: new Date(articleContent.pubdate)
-                                .getFullYear()
-                                .toString(), pmid: articleContent.uid }));
-                    }
-                });
-            }
-            this.props.abstracts.forEach(function (abstract) {
-                list.push(React.createElement(ArticleAbstractItem, { abstract: abstract.abstract, link: abstract.link }));
-            });
-            return React.createElement("ul", { className: styles$a['no-style-ul'] }, list);
-        }
-    });
-    __decorate([
-        computed
-    ], ReferenceList.prototype, "isLoading", null);
-    ReferenceList = __decorate([
-        observer
-    ], ReferenceList);
-    return ReferenceList;
-}(React.Component));
-
-var RefComponent = /** @class */ (function (_super) {
-    __extends(RefComponent, _super);
-    function RefComponent() {
-        return _super !== null && _super.apply(this, arguments) || this;
-    }
-    Object.defineProperty(RefComponent.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var _this = this;
-            var parts = this.props.content.split(/pmid|nct/i);
-            if (parts.length < 2) {
-                return React.createElement("span", null, this.props.content);
-            }
-            var ids = parts[1].match(/[0-9]+/g);
-            if (!ids) {
-                return React.createElement("span", null, this.props.content);
-            }
-            var prefix;
-            if (this.props.content.toLowerCase().indexOf('pmid') >= 0) {
-                prefix = 'PMID: ';
-            }
-            else if (this.props.content.toLowerCase().indexOf('nct') >= 0) {
-                prefix = 'NCT';
-            }
-            var link;
-            if (prefix) {
-                link = (React.createElement("a", { target: "_blank", href: getNCBIlink("/pubmed/" + ids.join(',')) }, "" + prefix + ids.join(',')));
-            }
-            if (this.props.componentType === 'tooltip') {
-                var tooltipContent = function () { return (React.createElement("div", { className: mainStyles['tooltip-refs'] },
-                    React.createElement(ReferenceList, { pmids: ids.map(function (id) { return parseInt(id); }), pmidData: _this.props.pmidData, abstracts: [] }))); };
-                return (React.createElement("span", { key: this.props.content },
-                    parts[0],
-                    React.createElement(DefaultTooltip, { overlay: tooltipContent, placement: "right", trigger: ['hover', 'focus'], destroyTooltipOnHide: true },
-                        React.createElement("i", { className: "fa fa-book", style: { color: 'black' } })), ")"));
-            }
-            else if (link) {
-                return (React.createElement("span", { key: this.props.content },
-                    parts[0],
-                    link, ")"));
-            }
-            else {
-                return React.createElement("span", null, this.props.content);
-            }
-        }
-    });
-    return RefComponent;
-}(React.Component));
-
-var SummaryWithRefs = /** @class */ (function (_super) {
-    __extends(SummaryWithRefs, _super);
-    function SummaryWithRefs() {
-        return _super !== null && _super.apply(this, arguments) || this;
-    }
-    Object.defineProperty(SummaryWithRefs.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var _this = this;
-            if (!this.props.content) {
-                return React.createElement("span", null);
-            }
-            var content = [];
-            // example delimiters:
-            //     (PMID: 11900253)
-            //     (PMID: 11753428, 16007150, 21467160)
-            //     (cBioPortal, MSKCC, May 2015, PMID: 24718888)
-            //     (NCT1234567)
-            var regex = /(\(.*?[PMID|NCT].*?\))/i;
-            // split the string with delimiters included
-            var parts = this.props.content.split(regex);
-            parts.forEach(function (part) {
-                // if delimiter convert to a JSX component
-                if (part.match(regex)) {
-                    content.push(React.createElement(RefComponent, { pmidData: _this.props.pmidData, componentType: _this.props.type, content: part }));
-                }
-                else {
-                    content.push(React.createElement("span", null, part));
-                }
-            });
-            return React.createElement("span", null, content);
-        }
-    });
-    return SummaryWithRefs;
-}(React.Component));
-
-var EvidenceReferenceContent = function (props) {
-    return (React__default.createElement(If, { condition: !!props.description },
-        React__default.createElement(Then, null,
-            React__default.createElement(SummaryWithRefs, { content: props.description, type: 'tooltip', pmidData: props.pmidData })),
-        React__default.createElement(Else, null,
-            React__default.createElement(If, { condition: props.citations != undefined &&
-                    (props.citations.abstracts.length > 0 ||
-                        props.citations.pmids.length > 0) },
-                React__default.createElement(Then, null,
-                    React__default.createElement(ReferenceList, { pmidData: props.pmidData, pmids: props.citations.pmids.map(function (pmid) {
-                            return Number(pmid);
-                        }), abstracts: props.citations.abstracts })),
-                React__default.createElement(Else, null, props.noInfoDisclaimer
-                    ? props.noInfoDisclaimer
-                    : 'Information is not available.')))));
-};
-
-var OncoKbTreatmentTable = /** @class */ (function (_super) {
-    __extends(OncoKbTreatmentTable, _super);
-    function OncoKbTreatmentTable() {
-        var _this = _super !== null && _super.apply(this, arguments) || this;
-        Object.defineProperty(_this, "levelTooltipContent", {
-            enumerable: true,
-            configurable: true,
-            writable: true,
-            value: function (level) {
-                return (React.createElement("div", { style: { maxWidth: '200px' } }, OncoKbHelper.LEVEL_DESC[level]));
-            }
-        });
-        Object.defineProperty(_this, "treatmentTooltipContent", {
-            enumerable: true,
-            configurable: true,
-            writable: true,
-            value: function (abstracts, pmids, pmidData, description) {
-                return abstracts.length > 0 || pmids.length > 0 ? (function () { return (React.createElement("div", { className: mainStyles['tooltip-refs'] },
-                    React.createElement(EvidenceReferenceContent, { description: description, citations: {
-                            pmids: pmids.map(function (pmid) { return pmid.toString(); }),
-                            abstracts: abstracts,
-                        }, pmidData: pmidData, noInfoDisclaimer: 'Mutation effect information is not available.' }))); }) : (React.createElement("span", null));
-            }
-        });
-        Object.defineProperty(_this, "columns", {
-            enumerable: true,
-            configurable: true,
-            writable: true,
-            value: [
-                OncoKbHelper.getDefaultColumnDefinition('level'),
-                __assign(__assign({}, OncoKbHelper.getDefaultColumnDefinition('alterations')), { Cell: function (props) {
-                        return OncoKbHelper.getAlterationsColumnCell(props.value, _this.props.variant);
-                    } }),
-                {
-                    id: 'treatment',
-                    Header: React.createElement("span", null, "Drug(s)"),
-                    accessor: 'drugs',
-                    Cell: function (props) { return (React.createElement("div", { style: { whiteSpace: 'normal', lineHeight: '1rem' } }, props.original.drugs
-                        .map(function (drug) { return drug.drugName; })
-                        .join(' + '))); },
-                },
-                {
-                    id: 'cancerType',
-                    Header: (React.createElement("span", null,
-                        "Level-associated",
-                        React.createElement("br", null),
-                        "cancer type(s)")),
-                    accessor: 'levelAssociatedCancerType',
-                    minWidth: 120,
-                    Cell: function (props) { return (React.createElement("div", { style: { whiteSpace: 'normal', lineHeight: '1rem' } }, getTumorTypeNameWithExclusionInfo(props.original.levelAssociatedCancerType, props.original.levelExcludedCancerTypes))); },
-                },
-                {
-                    id: 'referenceList',
-                    Header: React.createElement("span", null),
-                    sortable: false,
-                    maxWidth: 25,
-                    Cell: function (props) {
-                        return (props.original.abstracts.length > 0 ||
-                            props.original.pmids.length > 0) && (React.createElement(DefaultTooltip, { overlay: _this.treatmentTooltipContent(props.original.abstracts, props.original.pmids.map(function (pmid) { return Number(pmid); }), _this.props.pmidData, props.original.description), placement: "right", trigger: ['hover', 'focus'], destroyTooltipOnHide: true },
-                            React.createElement("i", { className: "fa fa-book" })));
-                    },
-                },
-            ]
-        });
-        return _this;
-    }
-    Object.defineProperty(OncoKbTreatmentTable.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            return (React.createElement("div", { className: "oncokb-treatment-table" },
-                React.createElement(ReactTable, { data: this.props.treatments, columns: this.columns, showPagination: false, pageSize: this.props.treatments.length, className: "-striped -highlight" })));
-        }
-    });
-    OncoKbTreatmentTable = __decorate([
-        observer
-    ], OncoKbTreatmentTable);
-    return OncoKbTreatmentTable;
-}(React.Component));
-
-var BiologicalContent = function (props) {
-    return (React__default.createElement(EvidenceReferenceContent, { description: props.biologicalSummary, citations: props.mutationEffectCitations, pmidData: props.pmidData, noInfoDisclaimer: 'Mutation effect information is not available.' }));
-};
-
-var ImplicationContent = function (props) {
-    var columns = [
-        __assign(__assign({}, OncoKbHelper.getDefaultColumnDefinition('level')), { accessor: 'levelOfEvidence', maxWidth: 100 }),
-        __assign(__assign({}, OncoKbHelper.getDefaultColumnDefinition('alterations')), { Cell: function (cellProps) {
-                return OncoKbHelper.getAlterationsColumnCell(cellProps.value, props.variant);
-            } }),
-        {
-            id: 'referenceList',
-            Header: React.createElement("span", null),
-            sortable: false,
-            maxWidth: 50,
-            Cell: function (cellProps) { return (React.createElement(DefaultTooltip, { overlay: function () { return (React.createElement("div", { className: mainStyles['tooltip-refs'] },
-                    React.createElement(EvidenceReferenceContent, { description: cellProps.original.description, citations: {
-                            pmids: cellProps.original.pmids,
-                            abstracts: cellProps.original.abstracts,
-                        }, pmidData: props.pmidData, noInfoDisclaimer: 'Mutation effect information is not available.' }))); }, placement: "right", trigger: ['hover', 'focus'], destroyTooltipOnHide: true },
-                React.createElement("i", { className: "fa fa-book" }))); },
-        },
-    ];
-    return (React.createElement("div", null,
-        React.createElement("p", null, props.summary),
-        React.createElement("div", null,
-            React.createElement(ReactTable, { data: props.implications, columns: columns, showPagination: false, pageSize: props.implications.length, className: "-striped -highlight" }))));
-};
-
-var tabsStyles = {"tabs-wrapper":"tabs-module_tabs-wrapper__XKjzo","tabs":"tabs-module_tabs__2I3mz","tab":"tabs-module_tab__3MoDA","tab-pane":"tabs-module_tab-pane__sGd85","tab-title-a":"tabs-module_tab-title-a__2WTNA","tab-title":"tabs-module_tab-title__2z9-D","tab-subtitle":"tabs-module_tab-subtitle__1P8B_"};
-
-var OncogenicIcon = function (props) {
-    return (React.createElement(DefaultTooltip, { overlay: React.createElement("span", null, props.oncogenicity), placement: "left", trigger: ['hover', 'focus'], destroyTooltipOnHide: true },
-        React.createElement("i", { className: oncogenicityIconClassNames(props.oncogenicity) })));
-};
-
-var _a$3;
-var OncoKbMedicalDisclaimer = (React__default.createElement("p", { className: mainStyles.disclaimer }, "The information above is intended for research purposes only and should not be used as a substitute for professional diagnosis and treatment."));
-var ONCOKB_DATA_ACCESS_PAGE_LINK = 'https://docs.cbioportal.org/2.4-integration-with-other-webservices/oncokb-data-access';
-var publicInstanceDisclaimerOverLay = (React__default.createElement("div", null,
-    React__default.createElement("p", null,
-        "This cBioPortal instance is not linked to an OncoKB\u2122 license, and therefore some OncoKB content is not available including therapeutic, diagnostic and prognostic implications. To obtain a license, please follow",
-        ' ',
-        React__default.createElement("a", { href: ONCOKB_DATA_ACCESS_PAGE_LINK, target: '_blank' }, "these instructions"),
-        "."),
-    OncoKbMedicalDisclaimer));
-var DATA_TYPE_TO_TITLE = (_a$3 = {},
-    _a$3[OncoKbCardDataType.BIOLOGICAL] = 'Biological Effect',
-    _a$3[OncoKbCardDataType.TXS] = 'Therapeutic Implications',
-    _a$3[OncoKbCardDataType.TXR] = 'Therapeutic Implications',
-    _a$3[OncoKbCardDataType.DX] = 'Diagnostic Implications',
-    _a$3[OncoKbCardDataType.PX] = 'Prognostic Implications',
-    _a$3);
-var TabContentWrapper = function (props) {
-    return React__default.createElement("div", { className: mainStyles['tab-content'] }, props.children);
-};
-var TabTitle = function (props) {
-    var _a;
-    var title = DATA_TYPE_TO_TITLE[props.type];
-    var icon = props.displayHighestLevelInTabTitle ? (props.type === OncoKbCardDataType.BIOLOGICAL ? (React__default.createElement(OncogenicIcon, { oncogenicity: ((_a = props.indicator) === null || _a === void 0 ? void 0 : _a.oncogenic) || '', showDescription: true })) : (React__default.createElement(LevelIcon, { level: normalizeLevel(calcHighestIndicatorLevel(props.type, props.indicator)) || '', showDescription: true }))) : null;
-    return icon ? (React__default.createElement("span", { style: { display: 'flex' } },
-        icon,
-        " ",
-        title)) : (React__default.createElement("span", null, title));
-};
-var OncoKbCardBody = function (props) {
-    var defaultTabActiveKey;
-    // Do not assign a default key if the data type specified through the property does not have any content
-    // When the content is not available, we do not render the tab.
-    if (dataTypeHasContent(props.type)) {
-        defaultTabActiveKey = props.type;
-        // Both TXS and TXR are therapeutic implication data type which will be shown in the same tab. We use TXS as the tab key when rendering
-        if ([OncoKbCardDataType.TXS, OncoKbCardDataType.TXR].includes(defaultTabActiveKey)) {
-            defaultTabActiveKey = OncoKbCardDataType.TXS;
-        }
-    }
-    var _a = useState(defaultTabActiveKey), activateTabKey = _a[0], setActivateTabKey = _a[1];
-    var _b = useState(getLevelsOfEvidence(activateTabKey)), levelsOfEvidence = _b[0], setLevelsOfEvidence = _b[1];
-    function updateActivateTabKey(newKey) {
-        setActivateTabKey(newKey);
-        setLevelsOfEvidence(getLevelsOfEvidence(newKey));
-    }
-    function hasMutationEffectInfo(mutationEffect) {
-        return (mutationEffect &&
-            (mutationEffect.description ||
-                mutationEffect.citations.abstracts.length > 0 ||
-                mutationEffect.citations.pmids.length > 0));
-    }
-    function dataTypeHasContent(type) {
-        var _a, _b, _c, _d, _e;
-        switch (type) {
-            case OncoKbCardDataType.BIOLOGICAL:
-                return hasMutationEffectInfo((_a = props.indicator) === null || _a === void 0 ? void 0 : _a.mutationEffect);
-            case OncoKbCardDataType.TXS:
-            case OncoKbCardDataType.TXR:
-                return (!!((_b = props.indicator) === null || _b === void 0 ? void 0 : _b.highestSensitiveLevel) ||
-                    !!((_c = props.indicator) === null || _c === void 0 ? void 0 : _c.highestResistanceLevel));
-            case OncoKbCardDataType.DX:
-                return !!((_d = props.indicator) === null || _d === void 0 ? void 0 : _d.highestDiagnosticImplicationLevel);
-            case OncoKbCardDataType.PX:
-                return !!((_e = props.indicator) === null || _e === void 0 ? void 0 : _e.highestPrognosticImplicationLevel);
-            default:
-                return false;
-        }
-    }
-    function getBody(type, indicator) {
-        var tabs = [];
-        if (dataTypeHasContent(OncoKbCardDataType.BIOLOGICAL)) {
-            tabs.push(React__default.createElement(Tab, { eventKey: OncoKbCardDataType.BIOLOGICAL, title: React__default.createElement(TabTitle, { type: OncoKbCardDataType.BIOLOGICAL, indicator: props.indicator, displayHighestLevelInTabTitle: props.displayHighestLevelInTabTitle }) },
-                React__default.createElement(TabContentWrapper, null,
-                    React__default.createElement(BiologicalContent, { mutationEffectCitations: indicator.mutationEffect.citations, biologicalSummary: indicator.mutationEffect.description, pmidData: props.pmidData }))));
-        }
-        if (!props.usingPublicOncoKbInstance &&
-            dataTypeHasContent(OncoKbCardDataType.TXS)) {
-            tabs.push(React__default.createElement(Tab, { eventKey: OncoKbCardDataType.TXS, title: React__default.createElement(TabTitle, { type: OncoKbCardDataType.TXS, indicator: props.indicator, displayHighestLevelInTabTitle: props.displayHighestLevelInTabTitle }) },
-                React__default.createElement(TabContentWrapper, null,
-                    React__default.createElement("div", { style: {
-                            marginTop: 10,
-                        } },
-                        React__default.createElement(OncoKbTreatmentTable, { variant: indicator.query.alteration || '', pmidData: props.pmidData, treatments: indicator.treatments })))));
-        }
-        if (!props.usingPublicOncoKbInstance &&
-            dataTypeHasContent(OncoKbCardDataType.DX)) {
-            tabs.push(React__default.createElement(Tab, { eventKey: OncoKbCardDataType.DX, title: React__default.createElement(TabTitle, { type: OncoKbCardDataType.DX, indicator: props.indicator, displayHighestLevelInTabTitle: props.displayHighestLevelInTabTitle }) },
-                React__default.createElement(TabContentWrapper, null,
-                    React__default.createElement(ImplicationContent, { variant: indicator.query.alteration, summary: indicator.diagnosticSummary, implications: indicator.diagnosticImplications, pmidData: props.pmidData }))));
-        }
-        if (!props.usingPublicOncoKbInstance &&
-            dataTypeHasContent(OncoKbCardDataType.PX)) {
-            tabs.push(React__default.createElement(Tab, { eventKey: OncoKbCardDataType.PX, title: React__default.createElement(TabTitle, { type: OncoKbCardDataType.PX, indicator: props.indicator, displayHighestLevelInTabTitle: props.displayHighestLevelInTabTitle }) },
-                React__default.createElement(TabContentWrapper, null,
-                    React__default.createElement(ImplicationContent, { variant: indicator.query.alteration, summary: indicator.prognosticSummary, implications: indicator.prognosticImplications, pmidData: props.pmidData }))));
-        }
-        return (React__default.createElement("div", { style: { padding: '10px' } },
-            React__default.createElement("p", null, indicator.geneSummary),
-            React__default.createElement("p", null, indicator.variantSummary),
-            props.usingPublicOncoKbInstance ? (React__default.createElement("p", { className: mainStyles.disclaimer },
-                "Therapeutic, diagnostic and prognostic implications are not available in this instance of cBioPortal.",
-                ' ',
-                React__default.createElement(DefaultTooltip, { overlayStyle: {
-                        maxWidth: 400,
-                    }, overlay: publicInstanceDisclaimerOverLay },
-                    React__default.createElement("i", { className: 'fa fa-info-circle' })))) : (React__default.createElement("p", null, indicator.tumorTypeSummary)),
-            tabs.length > 0 && (React__default.createElement(Tabs, { defaultActiveKey: defaultTabActiveKey, className: classnames('oncokb-card-tabs'), onSelect: updateActivateTabKey }, tabs))));
-    }
-    function getLevelsOfEvidence(activateTabKey) {
-        switch (activateTabKey) {
-            case OncoKbCardDataType.TXS:
-            case OncoKbCardDataType.TXR:
-                return {
-                    levels: OncoKbHelper.TX_LEVELS,
-                    levelDes: OncoKbHelper.getLevelsDesc(activateTabKey),
-                };
-            case OncoKbCardDataType.DX:
-                return {
-                    levels: OncoKbHelper.DX_LEVELS,
-                    levelDes: OncoKbHelper.getLevelsDesc(OncoKbCardDataType.DX),
-                };
-            case OncoKbCardDataType.PX:
-                return {
-                    levels: OncoKbHelper.PX_LEVELS,
-                    levelDes: OncoKbHelper.getLevelsDesc(OncoKbCardDataType.PX),
-                };
-            default:
-                return {
-                    levels: [],
-                    levelDes: {},
-                };
-        }
-    }
-    var UNKNOWN = 'Unknown';
-    function getOncogenicity() {
-        var _a;
-        var oncogenicity = (_a = props.indicator) === null || _a === void 0 ? void 0 : _a.oncogenic;
-        if (!oncogenicity || oncogenicity === UNKNOWN) {
-            oncogenicity = 'Unknown Oncogenic Effect';
-        }
-        return oncogenicity;
-    }
-    function getMutationEffect() {
-        var _a;
-        var mutationEffect = (_a = props.indicator) === null || _a === void 0 ? void 0 : _a.mutationEffect.knownEffect;
-        if (!mutationEffect || mutationEffect === UNKNOWN) {
-            mutationEffect = 'Unknown Biological Effect';
-        }
-        return mutationEffect;
-    }
-    return (React__default.createElement(React__default.Fragment, null,
-        !props.geneNotExist && (React__default.createElement("div", null,
-            props.indicator && (React__default.createElement(React__default.Fragment, null,
-                React__default.createElement("div", { className: mainStyles['biological-info'] },
-                    React__default.createElement("div", { style: { flexGrow: 1 } }, getOncogenicity()),
-                    React__default.createElement("div", { style: { flexGrow: 1 } }, getMutationEffect())),
-                React__default.createElement("div", { className: mainStyles['oncokb-card'], "data-test": "oncokb-card" }, getBody(props.type, props.indicator)))),
-            !props.usingPublicOncoKbInstance && (React__default.createElement(React__default.Fragment, null,
-                React__default.createElement("div", { className: tabsStyles['tab-pane'] }, OncoKbMedicalDisclaimer),
-                levelsOfEvidence &&
-                    levelsOfEvidence.levels.length > 0 && (React__default.createElement(OncoKbCardLevelsOfEvidenceDropdown, { levels: levelsOfEvidence.levels, levelDes: levelsOfEvidence.levelDes })))))),
-        !props.isCancerGene && (React__default.createElement("div", { className: mainStyles['additional-info'], "data-test": 'oncokb-card-additional-info' }, "There is currently no information about this gene in OncoKB.")),
-        props.geneNotExist && props.isCancerGene && (React__default.createElement("div", { className: mainStyles['additional-info'] },
-            React__default.createElement(OncoKBSuggestAnnotationLinkout, { gene: props.hugoSymbol })))));
-};
-
-var OncoKbCard = /** @class */ (function (_super) {
-    __extends(OncoKbCard, _super);
-    function OncoKbCard(props) {
-        var _this = _super.call(this, props) || this;
-        makeObservable(_this);
-        return _this;
-    }
-    Object.defineProperty(OncoKbCard.prototype, "oncokbLinkOut", {
-        get: function () {
-            var link = undefined;
-            if (this.props.hugoSymbol) {
-                link = "https://www.oncokb.org/gene/" + this.props.hugoSymbol;
-                if (!this.props.geneNotExist &&
-                    this.props.indicator &&
-                    this.props.indicator.variantExist) {
-                    link = link + "/" + this.props.indicator.query.alteration;
-                }
-            }
-            return link;
-        },
-        enumerable: false,
-        configurable: true
-    });
-    Object.defineProperty(OncoKbCard.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var oncokbLogo = (React.createElement("img", { src: oncoKbLogoImgSrc, className: mainStyles['oncokb-logo'], alt: "OncoKB\u2122" }));
-            return (React.createElement("div", { className: mainStyles['oncokb-card'], "data-test": "oncokb-card" },
-                React.createElement("div", null,
-                    !this.props.geneNotExist && this.props.indicator && (React.createElement(OncoKbCardTitle, { hugoSymbol: this.props.indicator.query.hugoSymbol, variant: this.props.indicator.query.alteration, tumorType: this.props.indicator
-                            ? this.props.indicator.query.tumorType
-                            : '' })),
-                    React.createElement(OncoKbCardBody, { type: this.props.type, indicator: this.props.indicator, geneNotExist: this.props.geneNotExist, isCancerGene: this.props.isCancerGene, hugoSymbol: this.props.hugoSymbol, pmidData: this.props.pmidData, usingPublicOncoKbInstance: this.props.usingPublicOncoKbInstance, displayHighestLevelInTabTitle: this.props.displayHighestLevelInTabTitle }),
-                    React.createElement("div", { className: mainStyles.footer },
-                        this.oncokbLinkOut === undefined ? ({ oncokbLogo: oncokbLogo }) : (React.createElement("a", { href: "" + this.oncokbLinkOut, target: "_blank", className: mainStyles['oncokb-logo'] }, oncokbLogo)),
-                        this.props.handleFeedbackOpen && (React.createElement("span", null,
-                            React.createElement("button", { className: "btn btn-default btn-xs", onClick: this.props.handleFeedbackOpen }, "Feedback")))))));
-        }
-    });
-    __decorate([
-        computed
-    ], OncoKbCard.prototype, "oncokbLinkOut", null);
-    OncoKbCard = __decorate([
-        observer
-    ], OncoKbCard);
-    return OncoKbCard;
-}(React.Component));
-
-/**
- * @author Selcuk Onur Sumer
- */
-var OncoKbTooltip = /** @class */ (function (_super) {
-    __extends(OncoKbTooltip, _super);
-    function OncoKbTooltip() {
-        return _super !== null && _super.apply(this, arguments) || this;
-    }
-    Object.defineProperty(OncoKbTooltip.prototype, "pmidData", {
-        get: function () {
-            if (this.props.pubMedCache) {
-                var allPmids_1 = [];
-                if (this.props.indicator) {
-                    if (this.props.indicator.mutationEffect) {
-                        allPmids_1 = allPmids_1.concat(this.props.indicator.mutationEffect.citations.pmids);
-                    }
-                    this.props.indicator.treatments.forEach(function (treatment) {
-                        allPmids_1 = allPmids_1.concat(treatment.pmids);
-                    });
-                    this.props.indicator.diagnosticImplications.forEach(function (implication) {
-                        allPmids_1 = allPmids_1.concat(implication.pmids);
-                    });
-                    this.props.indicator.prognosticImplications.forEach(function (implication) {
-                        allPmids_1 = allPmids_1.concat(implication.pmids);
-                    });
-                }
-                for (var _i = 0, _a = ___default.uniq(allPmids_1).map(function (pmid) { return Number(pmid); }); _i < _a.length; _i++) {
-                    var ref = _a[_i];
-                    this.props.pubMedCache.get(ref);
-                }
-            }
-            return (this.props.pubMedCache && this.props.pubMedCache.cache) || {};
-        },
-        enumerable: false,
-        configurable: true
-    });
-    Object.defineProperty(OncoKbTooltip.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var tooltipContent = React.createElement("span", null);
-            if (this.props.geneNotExist) {
-                tooltipContent = (React.createElement(OncoKbCard, { type: this.props.type, usingPublicOncoKbInstance: this.props.usingPublicOncoKbInstance, hugoSymbol: this.props.hugoSymbol, geneNotExist: this.props.geneNotExist, isCancerGene: this.props.isCancerGene, pmidData: {}, handleFeedbackOpen: this.props.handleFeedbackOpen, displayHighestLevelInTabTitle: true }));
-            }
-            if (!this.props.indicator) {
-                return tooltipContent;
-            }
-            if (!this.props.geneNotExist) {
-                var pmidData = this.pmidData;
-                tooltipContent = (React.createElement(OncoKbCard, { type: this.props.type, usingPublicOncoKbInstance: this.props.usingPublicOncoKbInstance, geneNotExist: this.props.geneNotExist, isCancerGene: this.props.isCancerGene, hugoSymbol: this.props.hugoSymbol, indicator: this.props.indicator, pmidData: pmidData, handleFeedbackOpen: this.props.handleFeedbackOpen, displayHighestLevelInTabTitle: true }));
-            }
-            return tooltipContent;
+                                        React.createElement("b", null, this.props.geneName))),
+                                ' ',
+                                "- ",
+                                this.props.geneDescription)),
+                        React.createElement("div", { className: "col s12" },
+                            React.createElement("ul", null, this.generateVariants(this.props.variants))),
+                        React.createElement("div", { className: "item disclaimer" },
+                            React.createElement("span", null, "Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.")))),
+                React.createElement("div", { className: "item footer" },
+                    React.createElement("a", { href: this.props.geneUrl, target: "_blank" },
+                        React.createElement("img", { src: img$5, className: "civic-logo", alt: "CIViC" })))));
         }
     });
-    OncoKbTooltip = __decorate([
-        observer
-    ], OncoKbTooltip);
-    return OncoKbTooltip;
+    return CivicCard;
 }(React.Component));
 
-var OncoKbFeedback = /** @class */ (function (_super) {
-    __extends(OncoKbFeedback, _super);
-    function OncoKbFeedback() {
-        return _super !== null && _super.apply(this, arguments) || this;
-    }
-    Object.defineProperty(OncoKbFeedback.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var url = 'https://docs.google.com/forms/d/1lt6TtecxHrhIE06gAKVF_JW4zKFoowNFzxn6PJv4g7A/viewform';
-            var geneParam = "entry.1744186665=" + (this.props.hugoSymbol || '');
-            var alterationParam = "entry.1671960263=" + (this.props.alteration ||
-                '');
-            var userParam = "entry.1381123986=" + (this.props.userEmailAddress ||
-                '');
-            var uriParam = "entry.1083850662=" + encodeURIComponent(window.location.href);
-            return (React.createElement(Modal, { show: this.props.showFeedback, onHide: this.props.handleFeedbackClose },
-                React.createElement(Modal.Header, { closeButton: true },
-                    React.createElement(Modal.Title, null, "OncoKB\u2122 Annotation Feedback")),
-                React.createElement(Modal.Body, null,
-                    React.createElement("iframe", { src: url + "?" + geneParam + "&" + alterationParam + "&entry.118699694&entry.1568641202&" + userParam + "&" + uriParam + "&embedded=true", style: {
-                            width: 550,
-                            height: 500,
-                            border: 'none',
-                            marginLeft: '10px',
-                        }, marginHeight: 0, marginWidth: 0 },
-                        React.createElement("i", { className: "fa fa-spinner fa-pulse fa-2x" })))));
-        }
-    });
-    return OncoKbFeedback;
-}(React.Component));
+var img$4 = "data:image/png;base64,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";
+
+var img$3 = "data:image/png;base64,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";
 
-function sortValue$6(indicator) {
-    var values = [0, 0, 0];
-    if (indicator) {
-        values[0] = calcOncogenicScore(indicator.oncogenic);
-        values[1] = calcSensitivityLevelScore(indicator.highestSensitiveLevel);
-        values[2] = calcResistanceLevelScore(indicator.highestResistanceLevel);
-        values[3] = calcDiagnosticLevelScore(indicator.highestDiagnosticImplicationLevel);
-        values[4] = calcPrognosticLevelScore(indicator.highestPrognosticImplicationLevel);
-    }
-    return values;
+function hideArrow(tooltipEl) {
+    var arrowEl = tooltipEl.querySelector('.rc-tooltip-arrow');
+    arrowEl.style.display = 'none';
 }
-function download$5(indicator) {
-    var _a, _b;
-    if (!indicator) {
-        return 'NA';
+function sortValue$7(civicEntry) {
+    var score = 0;
+    if (civicEntry) {
+        score = 1;
     }
-    var oncogenic = indicator.oncogenic ? indicator.oncogenic : 'Unknown';
-    var sensitivityLevel = ((_a = indicator.highestSensitiveLevel) === null || _a === void 0 ? void 0 : _a.toLowerCase()) || 'level NA';
-    var resistanceLevel = ((_b = indicator.highestResistanceLevel) === null || _b === void 0 ? void 0 : _b.toLowerCase()) || 'resistance NA';
-    return oncogenic + ", " + sensitivityLevel + ", " + resistanceLevel;
+    return score;
 }
-function findDefaultDataTypeForTooltip(usingPublicOncoKbInstance, indicator, availableDataTypes) {
-    if (usingPublicOncoKbInstance || !indicator) {
-        return OncoKbCardDataType.BIOLOGICAL;
-    }
-    // priority is in this order: Tx > Dx > Px > Biological
-    if (indicator.highestSensitiveLevel &&
-        availableDataTypes &&
-        availableDataTypes.includes(OncoKbCardDataType.TXS)) {
-        return OncoKbCardDataType.TXS;
-    }
-    else if (indicator.highestResistanceLevel &&
-        availableDataTypes &&
-        availableDataTypes.includes(OncoKbCardDataType.TXR)) {
-        return OncoKbCardDataType.TXR;
-    }
-    else if (indicator.highestDiagnosticImplicationLevel &&
-        availableDataTypes &&
-        availableDataTypes.includes(OncoKbCardDataType.DX)) {
-        return OncoKbCardDataType.DX;
-    }
-    else if (indicator.highestPrognosticImplicationLevel &&
-        availableDataTypes &&
-        availableDataTypes.includes(OncoKbCardDataType.PX)) {
-        return OncoKbCardDataType.PX;
-    }
-    return OncoKbCardDataType.BIOLOGICAL;
+function download$6(civicEntry) {
+    if (!civicEntry) {
+        return CIVIC_NA_VALUE;
+    }
+    var variants = ___default.values(civicEntry.variants);
+    var values = [];
+    if (variants && variants.length > 0 && variants[0].evidenceCounts) {
+        ___default.forEach(variants[0].evidenceCounts, function (value, key) {
+            values.push(key + ": " + value);
+        });
+    }
+    // this indicates that we have an entry but the evidence is empty
+    if (values.length === 0) {
+        return CIVIC_NA_VALUE;
+    }
+    return values.join(', ');
 }
-var OncoKB = /** @class */ (function (_super) {
-    __extends(OncoKB, _super);
-    function OncoKB(props) {
+var Civic = /** @class */ (function (_super) {
+    __extends(Civic, _super);
+    function Civic(props) {
         var _this = _super.call(this, props) || this;
-        Object.defineProperty(_this, "showFeedback", {
-            enumerable: true,
-            configurable: true,
-            writable: true,
-            value: false
-        });
         Object.defineProperty(_this, "tooltipDataLoadComplete", {
             enumerable: true,
             configurable: true,
@@ -1735,125 +184,136 @@ var OncoKB = /** @class */ (function (_super) {
             value: false
         });
         makeObservable(_this);
+        _this.cardContent = _this.cardContent.bind(_this);
         return _this;
     }
-    Object.defineProperty(OncoKB.prototype, "render", {
+    Object.defineProperty(Civic.prototype, "render", {
         enumerable: false,
         configurable: true,
         writable: true,
         value: function () {
-            var oncoKbContent;
-            if (this.props.status === 'error') {
-                oncoKbContent = errorIcon('Error fetching OncoKB data');
-            }
-            else if (this.props.status === 'pending') {
-                oncoKbContent = loaderIcon('pull-left');
+            var civicContent = (React.createElement("span", { className: "" + annotationStyles['annotation-item'] }));
+            var civicImgWidth = 14;
+            var civicImgHeight = 14;
+            var civicImgSrc = !this.props.hasCivicVariants
+                ? img$3
+                : img$4;
+            if (this.props.civicStatus == 'error') {
+                civicContent = errorIcon('Error fetching Civic data');
             }
-            else {
-                oncoKbContent = this.props.mergeAnnotationIcons
-                    ? this.singleAnnotationIcon()
-                    : this.multiAnnotationIcon();
-                if (!this.props.disableFeedback && this.showFeedback) {
-                    oncoKbContent = (React.createElement("span", null,
-                        oncoKbContent,
-                        React.createElement(OncoKbFeedback, { userEmailAddress: this.props.userEmailAddress, hugoSymbol: this.props.hugoGeneSymbol, alteration: this.props.indicator
-                                ? this.props.indicator.query.alteration
-                                : undefined, showFeedback: this.showFeedback, handleFeedbackClose: this.handleFeedbackClose })));
+            else if (this.props.civicEntry !== undefined) {
+                if (this.props.civicEntry !== null &&
+                    this.props.civicStatus == 'complete') {
+                    civicContent = (React.createElement("span", { className: "" + annotationStyles['annotation-item'] },
+                        React.createElement("img", { width: civicImgWidth, height: civicImgHeight, src: civicImgSrc, alt: "Civic Variant Entry" })));
+                    civicContent = (React.createElement(DefaultTooltip, { overlay: this.cardContent.bind(this, this.props.civicEntry), placement: "right", trigger: ['hover', 'focus'], onPopupAlign: hideArrow, destroyTooltipOnHide: false }, civicContent));
                 }
             }
-            return oncoKbContent;
-        }
-    });
-    Object.defineProperty(OncoKB.prototype, "multiAnnotationIcon", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            return (React.createElement("span", { className: "oncokb-content", style: { display: 'inline-flex' } },
-                React.createElement(AnnotationIcon, { type: OncoKbCardDataType.BIOLOGICAL, tooltipOverlay: this.tooltipContent(OncoKbCardDataType.BIOLOGICAL), indicator: this.props.indicator, availableDataTypes: this.props.availableDataTypes }),
-                this.levelIcons()));
-        }
-    });
-    Object.defineProperty(OncoKB.prototype, "levelIcons", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var _this = this;
-            if (this.props.usingPublicOncoKbInstance) {
-                return null;
-            }
-            if (this.props.indicator) {
-                return (React.createElement(React.Fragment, null, [
-                    OncoKbCardDataType.TXS,
-                    OncoKbCardDataType.TXR,
-                    OncoKbCardDataType.DX,
-                    OncoKbCardDataType.PX,
-                ].map(function (dataType) { return (React.createElement(AnnotationIcon, { type: dataType, tooltipOverlay: _this.tooltipContent(dataType), indicator: _this.props.indicator, availableDataTypes: _this.props.availableDataTypes })); })));
-            }
             else {
-                // workaround: use content padding value to draw an empty icon when there is no indicator data.
-                // this is to keep the icon alignment consistent with the rest of the column.
-                // ideally we should implement grouped columns to avoid these kind of workarounds
-                // (see https://github.com/cBioPortal/cbioportal/issues/8723)
-                return React.createElement("i", { style: { paddingRight: this.props.contentPadding } });
+                // It's still unknown (undefined) if the current gene has a Civic entry or not.
+                civicContent = loaderIcon('pull-left');
             }
+            return civicContent;
         }
     });
-    Object.defineProperty(OncoKB.prototype, "singleAnnotationIcon", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            return (React.createElement("span", { className: "oncokb-content", style: { display: 'inline-flex' } },
-                React.createElement(AnnotationIconWithTooltip, { tooltipOverlay: this.tooltipContent(findDefaultDataTypeForTooltip(this.props.usingPublicOncoKbInstance, this.props.indicator, this.props.availableDataTypes)), icon: React.createElement(CompactAnnotationIcon, { indicator: this.props.indicator, availableDataTypes: this.props.availableDataTypes, usingPublicOncoKbInstance: this.props.usingPublicOncoKbInstance }) })));
-        }
-    });
-    Object.defineProperty(OncoKB.prototype, "tooltipContent", {
+    Object.defineProperty(Civic.prototype, "cardContent", {
         enumerable: false,
         configurable: true,
         writable: true,
-        value: function (type) {
-            return (React.createElement(OncoKbTooltip, { type: type, usingPublicOncoKbInstance: this.props.usingPublicOncoKbInstance, hugoSymbol: this.props.hugoGeneSymbol, geneNotExist: this.props.geneNotExist, isCancerGene: this.props.isCancerGene, indicator: this.props.indicator || undefined, pubMedCache: this.props.pubMedCache, handleFeedbackOpen: this.props.disableFeedback
-                    ? undefined
-                    : this.handleFeedbackOpen }));
+        value: function (civicEntry) {
+            return (React.createElement(CivicCard, { title: "CIViC Variants", geneName: civicEntry.name, geneDescription: civicEntry.description, geneUrl: civicEntry.url, variants: civicEntry.variants }));
         }
     });
-    Object.defineProperty(OncoKB.prototype, "handleFeedbackOpen", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            this.showFeedback = true;
+    __decorate([
+        observable
+    ], Civic.prototype, "tooltipDataLoadComplete", void 0);
+    Civic = __decorate([
+        observer
+    ], Civic);
+    return Civic;
+}(React.Component));
+
+var NoClinvarData = function () {
+    return (React.createElement(DefaultTooltip, { placement: "topLeft", overlay: React.createElement("span", null, "Variant has no ClinVar data.") },
+        React.createElement("span", { style: {
+                height: '100%',
+                width: '100%',
+                display: 'block',
+                overflow: 'hidden',
+            } }, "\u00A0")));
+};
+var ClinvarSummary = function (props) {
+    if (!props.clinvar) {
+        return React.createElement(NoClinvarData, null);
+    }
+    else {
+        var clinvarId = props.clinvar.clinvarId;
+        var clinvarLink = "https://www.ncbi.nlm.nih.gov/clinvar/variation/" + clinvarId + "/";
+        var clinicalSignificance = props.clinvar.clinicalSignificance;
+        var conflictingClinicalSignificance = props.clinvar.conflictingClinicalSignificance;
+        return (React.createElement(TruncatedText, { maxLength: 30, text: clinicalSignificance, addTooltip: "always", tooltip: React.createElement("div", { style: { maxWidth: 300 } },
+                React.createElement("div", null, clinicalSignificance),
+                conflictingClinicalSignificance && (React.createElement("div", null, conflictingClinicalSignificance)),
+                React.createElement("div", null,
+                    "(ClinVar ID:",
+                    ' ',
+                    React.createElement("a", { href: clinvarLink, target: "_blank" }, clinvarId),
+                    ")")) }));
+    }
+};
+
+var img$2 = "data:image/png;base64,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";
+
+var mcgStyles = {"link-list":"myCancerGenome-module_link-list__2wFhH"};
+
+function placeArrow$1(tooltipEl) {
+    var arrowEl = tooltipEl.querySelector('.rc-tooltip-arrow');
+    arrowEl.style.left = '10px';
+}
+function sortValue$6(links) {
+    return links.length > 0 ? 1 : 0;
+}
+function download$5(links) {
+    return links.length > 0 ? 'present' : 'not present';
+}
+function myCancerGenomeLinks(linksHTML) {
+    var links = [];
+    ___default.each(linksHTML, function (link, index) {
+        // TODO this is a workaround, ideally we should fix the data itself
+        // parse the data as an HTML dom element, since it is formatted as an HTML link.
+        var myCancerGenomeLink = parseMyCancerGenomeLink(link);
+        if (myCancerGenomeLink) {
+            links.push(React.createElement("li", { key: index },
+                React.createElement("a", { href: myCancerGenomeLink.url, target: "_blank" }, myCancerGenomeLink.text)));
         }
     });
-    Object.defineProperty(OncoKB.prototype, "handleFeedbackClose", {
+    return (React.createElement("span", null,
+        React.createElement("b", null, "My Cancer Genome links:"),
+        React.createElement("br", null),
+        React.createElement("ul", { className: mcgStyles['link-list'] }, links)));
+}
+var MyCancerGenome = /** @class */ (function (_super) {
+    __extends(MyCancerGenome, _super);
+    function MyCancerGenome() {
+        return _super !== null && _super.apply(this, arguments) || this;
+    }
+    Object.defineProperty(MyCancerGenome.prototype, "render", {
         enumerable: false,
         configurable: true,
         writable: true,
         value: function () {
-            this.showFeedback = false;
+            var myCancerGenomeContent = (React.createElement("span", { className: "" + annotationStyles['annotation-item'] }));
+            if (this.props.linksHTML.length > 0) {
+                var arrowContent = React.createElement("div", { className: "rc-tooltip-arrow-inner" });
+                var tooltipContent = myCancerGenomeLinks(this.props.linksHTML);
+                myCancerGenomeContent = (React.createElement(DefaultTooltip, { overlay: tooltipContent, placement: "topLeft", trigger: ['hover', 'focus'], arrowContent: arrowContent, onPopupAlign: placeArrow$1 },
+                    React.createElement("span", { className: annotationStyles['annotation-item'] + " mcg" },
+                        React.createElement("img", { width: "14", height: "14", src: img$2, alt: "My Cancer Genome Symbol" }))));
+            }
+            return myCancerGenomeContent;
         }
     });
-    __decorate([
-        observable
-    ], OncoKB.prototype, "showFeedback", void 0);
-    __decorate([
-        observable
-    ], OncoKB.prototype, "tooltipDataLoadComplete", void 0);
-    __decorate([
-        autobind
-    ], OncoKB.prototype, "tooltipContent", null);
-    __decorate([
-        autobind
-    ], OncoKB.prototype, "handleFeedbackOpen", null);
-    __decorate([
-        autobind
-    ], OncoKB.prototype, "handleFeedbackClose", null);
-    OncoKB = __decorate([
-        observer
-    ], OncoKB);
-    return OncoKB;
+    return MyCancerGenome;
 }(React.Component));
 
 var hotspotStyles = {"hotspot-info":"hotspotInfo-module_hotspot-info__S24fX"};
@@ -2231,17 +691,17 @@ function annotationSortMethod(a, b) {
 }
 function sortValue$4(annotation) {
     return ___default.flatten([
-        sortValue$6(annotation.oncoKbIndicator),
-        sortValue$8(annotation.civicEntry),
-        sortValue$7(annotation.myCancerGenomeLinks),
+        oncoKbAnnotationSortValue(annotation.oncoKbIndicator),
+        sortValue$7(annotation.civicEntry),
+        sortValue$6(annotation.myCancerGenomeLinks),
         sortValue$5(annotation.isHotspot, annotation.is3dHotspot),
         annotation.isOncoKbCancerGene ? 1 : 0,
     ]);
 }
 function GenericAnnotation(props) {
-    var annotation = props.annotation, enableCivic = props.enableCivic, enableHotspot = props.enableHotspot, enableMyCancerGenome = props.enableMyCancerGenome, enableOncoKb = props.enableOncoKb, pubMedCache = props.pubMedCache, userEmailAddress = props.userEmailAddress, mergeOncoKbIcons = props.mergeOncoKbIcons, oncoKbContentPadding = props.oncoKbContentPadding;
+    var annotation = props.annotation, enableCivic = props.enableCivic, enableHotspot = props.enableHotspot, enableMyCancerGenome = props.enableMyCancerGenome, enableOncoKb = props.enableOncoKb; props.pubMedCache; var userEmailAddress = props.userEmailAddress, mergeOncoKbIcons = props.mergeOncoKbIcons, oncoKbContentPadding = props.oncoKbContentPadding;
     return (React.createElement("span", { style: { display: 'flex', minWidth: 100 } },
-        enableOncoKb && (React.createElement(OncoKB, { usingPublicOncoKbInstance: annotation.usingPublicOncoKbInstance, hugoGeneSymbol: annotation.hugoGeneSymbol, geneNotExist: !annotation.oncoKbGeneExist, isCancerGene: annotation.isOncoKbCancerGene, status: annotation.oncoKbStatus, indicator: annotation.oncoKbIndicator, availableDataTypes: annotation.oncoKbAvailableDataTypes, mergeAnnotationIcons: mergeOncoKbIcons, pubMedCache: pubMedCache, userEmailAddress: userEmailAddress, contentPadding: oncoKbContentPadding })),
+        enableOncoKb && (React.createElement(OncoKB, { usingPublicOncoKbInstance: annotation.usingPublicOncoKbInstance, hugoGeneSymbol: annotation.hugoGeneSymbol, geneNotExist: !annotation.oncoKbGeneExist, isCancerGene: annotation.isOncoKbCancerGene, status: annotation.oncoKbStatus, indicator: annotation.oncoKbIndicator, availableDataTypes: annotation.oncoKbAvailableDataTypes, mergeAnnotationIcons: mergeOncoKbIcons, userEmailAddress: userEmailAddress, contentPadding: oncoKbContentPadding })),
         enableCivic && (React.createElement(Civic, { civicEntry: annotation.civicEntry, civicStatus: annotation.civicStatus, hasCivicVariants: annotation.hasCivicVariants })),
         enableMyCancerGenome && (React.createElement(MyCancerGenome, { linksHTML: annotation.myCancerGenomeLinks })),
         enableHotspot && (React.createElement(HotspotAnnotation, { isHotspot: annotation.isHotspot, is3dHotspot: annotation.is3dHotspot, status: annotation.hotspotStatus }))));
@@ -3307,7 +1767,7 @@ var DropdownSelector = /** @class */ (function (_super) {
             var _a;
             var allValuesSelected = this.allValues.length === this.selectedValues.length;
             var classes = this.props.selectionIndicatorClassNames;
-            return classnames(classes.base, (_a = {},
+            return classNames(classes.base, (_a = {},
                 _a[classes.allSelected] = allValuesSelected,
                 _a[classes.partiallySelected] = !allValuesSelected,
                 _a));
@@ -4049,8 +2509,8 @@ var FilterResetPanel = /** @class */ (function (_super) {
         writable: true,
         value: {
             buttonText: 'Show all',
-            buttonClass: classnames('btn', 'btn-secondary', 'btn-sm'),
-            className: classnames('alert', 'alert-success', styles$7.filterResetPanel),
+            buttonClass: classNames('btn', 'btn-secondary', 'btn-sm'),
+            className: classNames('alert', 'alert-success', styles$7.filterResetPanel),
         }
     });
     FilterResetPanel = __decorate([
@@ -4465,7 +2925,7 @@ var DataTable = /** @class */ (function (_super) {
         value: function () {
             return (React.createElement("div", { className: "cbioportal-frontend" },
                 React.createElement(DataTableToolbar, { visibilityToggle: this.onVisibilityToggle, showSearchBox: this.props.showSearchBox, onSearch: this.onSearch, filterInputRef: this.filterInputRef, searchDelay: this.props.searchDelay, searchPlaceHolder: this.props.searchPlaceholder, info: this.props.info, showColumnVisibility: this.props.showColumnVisibility, columnVisibility: this.columnVisibilityDef, columnSelectorProps: this.props.columnSelectorProps }),
-                React.createElement("div", { className: classnames(this.props.className, 'cbioportal-frontend', 'default-data-table') },
+                React.createElement("div", { className: classNames(this.props.className, 'cbioportal-frontend', 'default-data-table') },
                     React.createElement(ReactTable, __assign({ data: this.tableData, columns: this.columns, getTrProps: this.needToCustomizeRowStyle
                             ? this.getTrProps
                             : undefined, defaultSorted: this.defaultSorted, defaultPageSize: this.props.initialItemsPerPage, showPagination: this.showPagination, className: "-striped -highlight", previousText: "<", nextText: ">", expanded: this.expanded, onExpandedChange: this.onExpandedChange, onPageChange: this.resetExpander, onPageSizeChange: this.resetExpander, onSortedChange: this.resetExpander, minRows: 1 }, this.props.reactTableProps)))));
@@ -7334,7 +5794,7 @@ var LollipopMutationPlotControls = /** @class */ (function (_super) {
     });
     Object.defineProperty(LollipopMutationPlotControls.prototype, "trackSelector", {
         get: function () {
-            return (React.createElement("div", { className: classnames('annotation-track-selector', 'small'), style: { width: 180, marginRight: 7 } },
+            return (React.createElement("div", { className: classNames('annotation-track-selector', 'small'), style: { width: 180, marginRight: 7 } },
                 React.createElement(TrackSelector, { tracks: this.props.tracks, trackVisibility: this.props.trackVisibility, trackDataStatus: this.props.trackDataStatus, onChange: this.props.onTrackVisibilityChange })));
         },
         enumerable: false,
@@ -7361,7 +5821,7 @@ var LollipopMutationPlotControls = /** @class */ (function (_super) {
         configurable: true,
         writable: true,
         value: function () {
-            return (React.createElement("div", { className: classnames('lollipop_mutation_plot__controls', this.props.showControls
+            return (React.createElement("div", { className: classNames('lollipop_mutation_plot__controls', this.props.showControls
                     ? styles$5['fade-in']
                     : styles$5['fade-out']) },
                 React.createElement("div", { style: { display: 'flex', alignItems: 'center' } },
@@ -7974,7 +6434,7 @@ var Track = /** @class */ (function (_super) {
                     position: 'relative',
                     display: 'flex',
                 } },
-                React.createElement("span", { className: classnames(styles$4.trackTitle, 'small', (this.props.isSubTrack ? 'subtrack-' : '') + "trackTitle") }, this.props.trackTitle),
+                React.createElement("span", { className: classNames(styles$4.trackTitle, 'small', (this.props.isSubTrack ? 'subtrack-' : '') + "trackTitle") }, this.props.trackTitle),
                 React.createElement("span", null,
                     React.createElement(DefaultTooltip, __assign({ placement: this.getOverlayPlacement(), overlay: this.getOverlay, onVisibleChange: this.onTooltipVisibleChange, destroyTooltipOnHide: true }, this.tooltipVisibleProps), this.hitZone),
                     React.createElement("span", { style: { marginLeft: this.props.xOffset }, onMouseOver: this.onMouseOver },
@@ -8134,130 +6594,6 @@ var OncoKbFilterValue;
     OncoKbFilterValue["Oncogenic"] = "ONCOGENIC";
 })(OncoKbFilterValue || (OncoKbFilterValue = {}));
 
-var OncoKbSummaryTable = /** @class */ (function (_super) {
-    __extends(OncoKbSummaryTable, _super);
-    function OncoKbSummaryTable(props) {
-        var _this = _super.call(this, props) || this;
-        makeObservable(_this);
-        _this.state = {};
-        return _this;
-    }
-    OncoKbSummaryTable_1 = OncoKbSummaryTable;
-    Object.defineProperty(OncoKbSummaryTable.prototype, "hasLevelData", {
-        get: function () {
-            return this.props.data.find(function (d) { return d.level.length > 0; }) !== undefined;
-        },
-        enumerable: false,
-        configurable: true
-    });
-    Object.defineProperty(OncoKbSummaryTable.prototype, "columns", {
-        get: function () {
-            var columns = [
-                {
-                    id: 'proteinChange',
-                    accessor: 'proteinChange',
-                    Header: 'Protein Change',
-                    sortMethod: function (a, b) {
-                        return defaultSortMethod(calcProteinChangeSortValue(a), calcProteinChangeSortValue(b));
-                    },
-                },
-                {
-                    id: 'count',
-                    accessor: 'count',
-                    Header: 'Occurrence',
-                    maxWidth: 80,
-                },
-                {
-                    id: 'clinicalImplication',
-                    accessor: 'clinicalImplication',
-                    Header: 'Implication',
-                    Cell: function (props) { return (React.createElement("span", null, props.original.clinicalImplication.join(', '))); },
-                    sortMethod: defaultStringArraySortMethod,
-                    minWidth: 120,
-                },
-                {
-                    id: 'biologicalEffect',
-                    accessor: 'biologicalEffect',
-                    Header: 'Effect',
-                    Cell: function (props) { return (React.createElement("span", null, props.original.biologicalEffect.join(', '))); },
-                    sortMethod: defaultStringArraySortMethod,
-                    minWidth: 150,
-                },
-            ];
-            if (!this.props.usingPublicOncoKbInstance) {
-                columns.push({
-                    id: 'level',
-                    accessor: 'level',
-                    Header: 'Level',
-                    sortable: false,
-                    Cell: function (props) { return (React.createElement(React.Fragment, null, props.original.level.map(function (level) { return (React.createElement("div", { key: level.level, style: {
-                            display: 'flex',
-                            overflow: 'hidden',
-                            textOverflow: 'ellipsis',
-                        } },
-                        React.createElement(LevelIcon, { level: level.level, showDescription: true }),
-                        React.createElement("span", { style: {
-                                paddingRight: 3,
-                            } }, ":"),
-                        React.createElement(EllipsisTextTooltip, { text: level.tumorTypes.join(', '), style: {
-                                overflow: 'hidden',
-                                whiteSpace: 'nowrap',
-                                textOverflow: 'ellipsis',
-                            } }))); }))); },
-                    minWidth: this.hasLevelData ? 180 : 50,
-                });
-            }
-            return columns;
-        },
-        enumerable: false,
-        configurable: true
-    });
-    Object.defineProperty(OncoKbSummaryTable.prototype, "render", {
-        enumerable: false,
-        configurable: true,
-        writable: true,
-        value: function () {
-            var _a = this.props, data = _a.data, initialSortColumn = _a.initialSortColumn, initialSortDirection = _a.initialSortDirection, initialItemsPerPage = _a.initialItemsPerPage;
-            var showPagination = data.length >
-                (this.props.initialItemsPerPage ||
-                    OncoKbSummaryTable_1.defaultProps.initialItemsPerPage);
-            return (React.createElement("div", { className: classnames('cbioportal-frontend', 'default-track-tooltip-table') },
-                React.createElement(ReactTable, { data: data, columns: this.columns, defaultSorted: [
-                        {
-                            id: initialSortColumn ||
-                                OncoKbSummaryTable_1.defaultProps
-                                    .initialSortColumn,
-                            desc: initialSortDirection === 'desc',
-                        },
-                    ], defaultPageSize: data.length > initialItemsPerPage
-                        ? initialItemsPerPage
-                        : data.length, showPagination: showPagination, showPaginationTop: true, showPaginationBottom: false, className: "-striped -highlight", previousText: "<", nextText: ">" })));
-        }
-    });
-    var OncoKbSummaryTable_1;
-    Object.defineProperty(OncoKbSummaryTable, "defaultProps", {
-        enumerable: true,
-        configurable: true,
-        writable: true,
-        value: {
-            data: [],
-            initialSortColumn: 'count',
-            initialSortDirection: 'desc',
-            initialItemsPerPage: 10,
-        }
-    });
-    __decorate([
-        computed
-    ], OncoKbSummaryTable.prototype, "hasLevelData", null);
-    __decorate([
-        computed
-    ], OncoKbSummaryTable.prototype, "columns", null);
-    OncoKbSummaryTable = OncoKbSummaryTable_1 = __decorate([
-        observer
-    ], OncoKbSummaryTable);
-    return OncoKbSummaryTable;
-}(React.Component));
-
 function oncoKbTooltip(usingPublicOncoKbInstance, indicatorData) {
     var sampleCount = indicatorData.length;
     // generate info
@@ -8579,7 +6915,7 @@ var PtmReferenceList = /** @class */ (function (_super) {
                     } },
                     React.createElement(ReferenceList, { pmids: this.props.pubmedIds
                             .map(function (id) { return extractNumericalPart(id); })
-                            .filter(function (id) { return id !== undefined; }), pmidData: this.props.pmidData, abstracts: [] })), destroyTooltipOnHide: true },
+                            .filter(function (id) { return id !== undefined; }), abstracts: [] })), destroyTooltipOnHide: true },
                 React.createElement("div", { style: { textAlign: 'right' } },
                     React.createElement("i", { className: "fa fa-book", style: { color: 'black' } }))));
         }
@@ -8704,7 +7040,7 @@ var PtmAnnotationTable = /** @class */ (function (_super) {
             var showPagination = data.length >
                 (this.props.initialItemsPerPage ||
                     PtmAnnotationTable_1.defaultProps.initialItemsPerPage);
-            return (React.createElement("div", { className: classnames('cbioportal-frontend', 'default-track-tooltip-table') },
+            return (React.createElement("div", { className: classNames('cbioportal-frontend', 'default-track-tooltip-table') },
                 React.createElement(ReactTable, { data: data, columns: this.columns, defaultSorted: [
                         {
                             id: initialSortColumn ||
@@ -10128,7 +8464,7 @@ var AxisScaleSwitch = /** @class */ (function (_super) {
         configurable: true,
         writable: true,
         value: function (scale, onClick) {
-            return (React.createElement("button", { className: classnames({
+            return (React.createElement("button", { className: classNames({
                     'btn-secondary': this.props.selectedScale === scale,
                     'btn-outline-secondary': this.props.selectedScale !== scale,
                 }, 'btn', 'btn-sm', 'btn-axis-switch'), style: {
@@ -10139,6 +8475,9 @@ var AxisScaleSwitch = /** @class */ (function (_super) {
                     fontWeight: this.props.selectedScale === scale
                         ? 'bolder'
                         : 'normal',
+                    color: this.props.selectedScale === scale ? '#fff' : '#6c757d',
+                    backgroundColor: this.props.selectedScale === scale ? '#6c757d' : '#fff',
+                    borderColor: '#6c757d',
                 }, onClick: onClick }, scale));
         }
     });
@@ -12330,7 +10669,7 @@ var TranscriptDropdown = /** @class */ (function (_super) {
                     canonicalTranscriptId &&
                     transcriptsWithAnnotations.result &&
                     transcriptsWithAnnotations.result.length > 0;
-                return (React.createElement("div", { className: classnames('small', styles$1.dropDown) },
+                return (React.createElement("div", { className: classNames('small', styles$1.dropDown) },
                     this.loadingIndicator(isLoading),
                     !isLoading &&
                         requiredData &&
@@ -12343,7 +10682,7 @@ var TranscriptDropdown = /** @class */ (function (_super) {
                 var requiredData = transcriptsWithProteinLength.result &&
                     transcriptsWithProteinLength.result.length > 0 &&
                     canonicalTranscriptId;
-                return (React.createElement("div", { className: classnames('small', styles$1.dropDown) },
+                return (React.createElement("div", { className: classNames('small', styles$1.dropDown) },
                     this.loadingIndicator(isLoading),
                     !isLoading &&
                         requiredData &&
@@ -12971,5 +11310,5 @@ var MutationMapper = /** @class */ (function (_super) {
     return MutationMapper;
 }(React.Component));
 
-export { Annotation, AxisScale, AxisScaleSwitch, BadgeLabel, BadgeSelector, Civic, ClinvarInterpretation, ClinvarSummary, ColumnHeader, ColumnSelector, ColumnSortDirection, DEFAULT_ANNOTATION_DATA, DEFAULT_GENOME_NEXUS_URL, DEFAULT_MUTATION_ALIGNER_PROXY_URL_TEMPLATE, DEFAULT_MUTATION_ALIGNER_URL_TEMPLATE, DEFAULT_MUTATION_COLUMNS, DEFAULT_MY_GENE_URL_TEMPLATE, DEFAULT_ONCO_KB_URL, DEFAULT_PROTEIN_IMPACT_TYPE_COLORS, DEFAULT_UNIPROT_ID_URL_TEMPLATE, DataFilterType, DataTable, Dbsnp, DbsnpId, DefaultMutationMapperDataFetcher, DefaultMutationMapperDataStore, DefaultMutationMapperFilterApplier, DefaultMutationMapperStore, DefaultMutationTable, Domain, DropdownSelector, FilterResetPanel, GenericAnnotation, Gnomad, GnomadFrequency, GnomadFrequencyBreakdown, GnomadFrequencyTable, GnomadFrequencyValue, Hgvsc, Hgvsg, HotspotAnnotation, HotspotInfo, Lollipop, LollipopMutationPlot, LollipopPlot, LollipopPlotNoTooltip, LollipopTooltipCountInfo, MSI_H_NAME, MUTATION_COLUMNS_DEFINITION, MUTATION_COLUMN_HEADERS, MUTATION_STATUS_BADGE_STYLE_OVERRIDE, MUTATION_TYPE_PRIORITY, MutationColumn, MutationColumnName, MutationMapper, MutationStatus, MutationStatusBadgeSelector, MyCancerGenome, ONCOKB_DEFAULT_DATA, ONCOKB_DEFAULT_INFO, OTHER_BIOMARKER_HUGO_SYMBOL, OTHER_BIOMARKER_NAME, OncoKB, OncoKBSuggestAnnotationLinkout, OncoKbFeedback, OncoKbHelper, OncoKbTooltip, OncoKbTreatmentTable, OtherBiomarkersQueryType, PercentToggle, ProteinChange, ProteinImpactTypeBadgeSelector, ProteinImpactTypeDropdownSelector, RefComponent, ReferenceList, LollipopPlot as Sequence, Signal, SignalTable, SummaryWithRefs, TEXT_INPUT_FILTER_ID, TMB_H_NAME, TrackName, TrackSelector, USE_DEFAULT_PUBLIC_INSTANCE_FOR_ONCOKB, sortValue$4 as annotationSortValue, applyDataFilters, applyDataFiltersOnDatum, applyDefaultMutationFilter, applyDefaultMutationStatusFilter, applyDefaultPositionFilter, applyDefaultProteinImpactTypeFilter, calculateGnomadAlleleFrequency, download$7 as civicDownload, sortValue$8 as civicSortValue, download$4 as clinvarDownload, sortValue$3 as clinvarSortValue, download$3 as dbsnpDownload, sortValue$2 as dbsnpSortValue, defaultOncoKbFilter, errorIcon, fetchVariantAnnotationsByMutation, fetchVariantAnnotationsIndexedByGenomicLocation, findAllUniquePositions, findNonTextInputFilters, findOneMutationFilterValue, findTextInputFilter, getAllOptionValues, getAnnotationData, getClinvarData, getColorForProteinImpactType, getGnomadData, getHgvscColumnData, getHgvsgColumnData, getProteinImpactTypeBadgeLabel, getProteinImpactTypeOptionLabel, getSelectedOptionValues, getSignalData, getSingleSignalValue, getTumorTypeNameWithExclusionInfo, getUrl, download$2 as gnomadDownload, sortValue$1 as gnomadSortValue, groupDataByGroupFilters, groupDataByProteinImpactType, groupOncoKbIndicatorDataByMutations, handleOptionSelect, download$1 as hgvscDownload, sortValue as hgvscSortValue, sortValue$5 as hotspotAnnotationSortValue, includesSearchTextIgnoreCase, indexPositions, initDefaultMutationMapperStore, initDefaultTrackVisibility, initGenomeNexusClient, initGenomeNexusInternalClient, initOncoKbClient, levelIconClassNames, loaderIcon, mergeColumns, mutationTypeSort, download$6 as myCancerGenomeDownload, sortValue$7 as myCancerGenomeSortValue, normalizeLevel, onFilterOptionSelect, download$5 as oncoKbAnnotationDownload, sortValue$6 as oncoKbAnnotationSortValue, oncogenicityIconClassNames, proteinChangeSortMethod, rightAlignedCell, download as signalDownload, getSortValue as signalSortValue, updatePositionHighlightFilters, updatePositionRangeHighlightFilters, updatePositionSelectionFilters };
+export { Annotation, AxisScale, AxisScaleSwitch, BadgeLabel, BadgeSelector, Civic, ClinvarInterpretation, ClinvarSummary, ColumnHeader, ColumnSelector, ColumnSortDirection, DEFAULT_ANNOTATION_DATA, DEFAULT_GENOME_NEXUS_URL, DEFAULT_MUTATION_ALIGNER_PROXY_URL_TEMPLATE, DEFAULT_MUTATION_ALIGNER_URL_TEMPLATE, DEFAULT_MUTATION_COLUMNS, DEFAULT_MY_GENE_URL_TEMPLATE, DEFAULT_ONCO_KB_URL, DEFAULT_PROTEIN_IMPACT_TYPE_COLORS, DEFAULT_UNIPROT_ID_URL_TEMPLATE, DataFilterType, DataTable, Dbsnp, DbsnpId, DefaultMutationMapperDataFetcher, DefaultMutationMapperDataStore, DefaultMutationMapperFilterApplier, DefaultMutationMapperStore, DefaultMutationTable, Domain, DropdownSelector, FilterResetPanel, GenericAnnotation, Gnomad, GnomadFrequency, GnomadFrequencyBreakdown, GnomadFrequencyTable, GnomadFrequencyValue, Hgvsc, Hgvsg, HotspotAnnotation, HotspotInfo, Lollipop, LollipopMutationPlot, LollipopPlot, LollipopPlotNoTooltip, LollipopTooltipCountInfo, MUTATION_COLUMNS_DEFINITION, MUTATION_COLUMN_HEADERS, MUTATION_STATUS_BADGE_STYLE_OVERRIDE, MUTATION_TYPE_PRIORITY, MutationColumn, MutationColumnName, MutationMapper, MutationStatus, MutationStatusBadgeSelector, MyCancerGenome, ONCOKB_DEFAULT_DATA, ONCOKB_DEFAULT_INFO, PercentToggle, ProteinChange, ProteinImpactTypeBadgeSelector, ProteinImpactTypeDropdownSelector, LollipopPlot as Sequence, Signal, SignalTable, TEXT_INPUT_FILTER_ID, TrackName, TrackSelector, USE_DEFAULT_PUBLIC_INSTANCE_FOR_ONCOKB, sortValue$4 as annotationSortValue, applyDataFilters, applyDataFiltersOnDatum, applyDefaultMutationFilter, applyDefaultMutationStatusFilter, applyDefaultPositionFilter, applyDefaultProteinImpactTypeFilter, calculateGnomadAlleleFrequency, download$6 as civicDownload, sortValue$7 as civicSortValue, download$4 as clinvarDownload, sortValue$3 as clinvarSortValue, download$3 as dbsnpDownload, sortValue$2 as dbsnpSortValue, fetchVariantAnnotationsByMutation, fetchVariantAnnotationsIndexedByGenomicLocation, findAllUniquePositions, findNonTextInputFilters, findOneMutationFilterValue, findTextInputFilter, getAllOptionValues, getAnnotationData, getClinvarData, getColorForProteinImpactType, getGnomadData, getHgvscColumnData, getHgvsgColumnData, getProteinImpactTypeBadgeLabel, getProteinImpactTypeOptionLabel, getSelectedOptionValues, getSignalData, getSingleSignalValue, getUrl, download$2 as gnomadDownload, sortValue$1 as gnomadSortValue, groupDataByGroupFilters, groupDataByProteinImpactType, handleOptionSelect, download$1 as hgvscDownload, sortValue as hgvscSortValue, sortValue$5 as hotspotAnnotationSortValue, includesSearchTextIgnoreCase, indexPositions, initDefaultMutationMapperStore, initDefaultTrackVisibility, initGenomeNexusClient, initGenomeNexusInternalClient, initOncoKbClient, mergeColumns, mutationTypeSort, download$5 as myCancerGenomeDownload, sortValue$6 as myCancerGenomeSortValue, onFilterOptionSelect, proteinChangeSortMethod, rightAlignedCell, download as signalDownload, getSortValue as signalSortValue, updatePositionHighlightFilters, updatePositionRangeHighlightFilters, updatePositionSelectionFilters };
 //# sourceMappingURL=index.es.js.map