heor-agent-mcp 0.2.0 → 0.7.0

package/dist/providers/direct/iqwig.js.map

@@ -1 +1 @@
-{"version":3,"file":"iqwig.js","sourceRoot":"","sources":["../../../src/providers/direct/iqwig.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,UAAU,CAC9B,KAAa,EACb,UAAkB;IAElB,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,yBAAyB,KAAK,EAAE;YACvC,QAAQ,EAAE,0PAA0P,KAAK,yKAAyK;YAClb,GAAG,EAAE,sDAAsD,kBAAkB,CAAC,KAAK,CAAC,EAAE;SACvF;QACD;YACE,KAAK,EAAE,mCAAmC;YAC1C,QAAQ,EAAE,+ZAA+Z;YACza,GAAG,EAAE,yDAAyD;SAC/D;QACD;YACE,KAAK,EAAE,wCAAwC;YAC/C,QAAQ,EAAE,wUAAwU;YAClV,GAAG,EAAE,2DAA2D;SACjE;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,SAAS,CAAC,EAAE;QAChB,MAAM,EAAE,OAAgB;QACxB,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE;YACP,sEAAsE;SACvE;QACD,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}
+{"version":3,"file":"iqwig.js","sourceRoot":"","sources":["../../../src/providers/direct/iqwig.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,UAAU,CAC9B,KAAa,EACb,UAAkB;IAElB,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,yBAAyB,KAAK,EAAE;YACvC,QAAQ,EAAE,0PAA0P,KAAK,yKAAyK;YAClb,GAAG,EAAE,qCAAqC,kBAAkB,CAAC,KAAK,CAAC,EAAE;SACtE;QACD;YACE,KAAK,EAAE,mCAAmC;YAC1C,QAAQ,EAAE,+ZAA+Z;YACza,GAAG,EAAE,yDAAyD;SAC/D;QACD;YACE,KAAK,EAAE,wCAAwC;YAC/C,QAAQ,EAAE,wUAAwU;YAClV,GAAG,EAAE,2DAA2D;SACjE;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,SAAS,CAAC,EAAE;QAChB,MAAM,EAAE,OAAgB;QACxB,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE;YACP,sEAAsE;SACvE;QACD,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}

package/dist/providers/direct/niceTa.d.ts

@@ -1,3 +1,7 @@
 import type { LiteratureResult } from "../types.js";
+/**
+ * Fetch NICE Technology Appraisals by scraping the NICE search page.
+ * Extracts guidance links (TA numbers) and titles from search results HTML.
+ */
 export declare function fetchNiceTa(query: string, maxResults: number): Promise<LiteratureResult[]>;
 //# sourceMappingURL=niceTa.d.ts.map

package/dist/providers/direct/niceTa.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"niceTa.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/niceTa.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,WAAW,CAC/B,KAAK,EAAE,MAAM,EACb,UAAU,EAAE,MAAM,GACjB,OAAO,CAAC,gBAAgB,EAAE,CAAC,CA6B7B"}
+{"version":3,"file":"niceTa.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/niceTa.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAIpD;;;GAGG;AACH,wBAAsB,WAAW,CAC/B,KAAK,EAAE,MAAM,EACb,UAAU,EAAE,MAAM,GACjB,OAAO,CAAC,gBAAgB,EAAE,CAAC,CAwE7B"}

package/dist/providers/direct/niceTa.js

@@ -1,30 +1,81 @@
+const NICE_SEARCH_URL = "https://www.nice.org.uk/search";
+/**
+ * Fetch NICE Technology Appraisals by scraping the NICE search page.
+ * Extracts guidance links (TA numbers) and titles from search results HTML.
+ */
 export async function fetchNiceTa(query, maxResults) {
-    const entries = [
-        {
-            title: `NICE Technology Appraisals Search: ${query}`,
-            abstract: `NICE Technology Appraisals (TAs) recommend whether NHS England should fund new medicines. Each TA includes: company submission, ERG (evidence review group) report, committee papers, final appraisal determination (FAD), and guidance. Search "${query}" across all published TAs to find precedents for similar indications, comparators, or ICER thresholds. Essential for NICE STA submission benchmarking.`,
-            url: `https://www.nice.org.uk/search?q=${encodeURIComponent(query)}&ngt=Guidance&ndt=Guidance#/?ngt=Guidance&ndt=Guidance`,
-        },
-        {
-            title: `NICE Single Technology Appraisal Process Guide`,
-            abstract: `NICE's STA methodology guide PMG36 and process guide PMG19. Required reading for company submissions. Covers reference case, time horizon, discount rates (3.5%), perspective (NHS+PSS), ICER threshold (£25–35K/QALY, updated April 2026), end-of-life criteria, and innovation rating.`,
-            url: "https://www.nice.org.uk/process/pmg36",
-        },
+    const url = `${NICE_SEARCH_URL}?q=${encodeURIComponent(query)}&ps=${Math.min(maxResults, 20)}`;
+    try {
+        const res = await fetch(url, {
+            headers: { Accept: "text/html" },
+            signal: AbortSignal.timeout(15000),
+        });
+        if (!res.ok) {
+            return fallbackResults(query, maxResults);
+        }
+        const html = await res.text();
+        // Extract guidance links and titles from search results
+        const results = [];
+        const guidancePattern = /href="(\/guidance\/(ta\d+))"[^>]*>([^<]+)/gi;
+        let match;
+        while ((match = guidancePattern.exec(html)) !== null &&
+            results.length < maxResults) {
+            const path = match[1];
+            const taId = match[2].toUpperCase();
+            const title = match[3].trim();
+            if (results.some((r) => r.id === taId))
+                continue;
+            results.push({
+                id: taId,
+                source: "nice_ta",
+                title: `[${taId}] ${title}`,
+                authors: ["National Institute for Health and Care Excellence (NICE)"],
+                date: new Date().getFullYear().toString(),
+                study_type: "hta_report",
+                abstract: `NICE Technology Appraisal ${taId}. Search query: "${query}". This guidance recommends whether NHS England should fund this treatment. View for full appraisal determination, committee papers, and evidence review.`,
+                url: `https://www.nice.org.uk${path}`,
+            });
+        }
+        // Also look for in-development appraisals
+        const indevelopPattern = /href="(\/guidance\/indevelopment\/(gid-[^"]+))"[^>]*>([^<]+)/gi;
+        while ((match = indevelopPattern.exec(html)) !== null &&
+            results.length < maxResults) {
+            const path = match[1];
+            const gid = match[2];
+            const title = match[3].trim();
+            if (results.some((r) => r.id === gid))
+                continue;
+            results.push({
+                id: gid,
+                source: "nice_ta",
+                title: `[In Development] ${title}`,
+                authors: ["National Institute for Health and Care Excellence (NICE)"],
+                date: new Date().getFullYear().toString(),
+                study_type: "hta_report",
+                abstract: `NICE appraisal in development (${gid}). Search query: "${query}".`,
+                url: `https://www.nice.org.uk${path}`,
+            });
+        }
+        if (results.length > 0)
+            return results;
+        return fallbackResults(query, maxResults);
+    }
+    catch {
+        return fallbackResults(query, maxResults);
+    }
+}
+function fallbackResults(query, maxResults) {
+    return [
         {
-            title: `NICE Committee Papers Archive`,
-            abstract: `Archive of NICE Appraisal Committee meeting papers including company submission dossiers, ERG critique reports, patient/clinical expert statements. Useful for understanding committee reasoning and common critiques.`,
-            url: `https://www.nice.org.uk/guidance/published?type=ta&ssup=committee-papers`,
+            id: "nice_ta_search",
+            source: "nice_ta",
+            title: `NICE Guidance Search: ${query}`,
+            authors: ["National Institute for Health and Care Excellence (NICE)"],
+            date: new Date().getFullYear().toString(),
+            study_type: "hta_report",
+            abstract: `No specific NICE Technology Appraisals found for "${query}". This may mean no TA has been published yet. Check the NICE website directly.`,
+            url: `https://www.nice.org.uk/search?q=${encodeURIComponent(query)}`,
         },
-    ];
-    return entries.slice(0, maxResults).map((e, i) => ({
-        id: `nice_ta_${i}`,
-        source: "nice_ta",
-        title: e.title,
-        authors: ["National Institute for Health and Care Excellence (NICE)"],
-        date: new Date().getFullYear().toString(),
-        study_type: "hta_report",
-        abstract: e.abstract,
-        url: e.url,
-    }));
+    ].slice(0, maxResults);
 }
 //# sourceMappingURL=niceTa.js.map

package/dist/providers/direct/niceTa.js.map

@@ -1 +1 @@
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+{"version":3,"file":"niceTa.js","sourceRoot":"","sources":["../../../src/providers/direct/niceTa.ts"],"names":[],"mappings":"AAEA,MAAM,eAAe,GAAG,gCAAgC,CAAC;AAEzD;;;GAGG;AACH,MAAM,CAAC,KAAK,UAAU,WAAW,CAC/B,KAAa,EACb,UAAkB;IAElB,MAAM,GAAG,GAAG,GAAG,eAAe,MAAM,kBAAkB,CAAC,KAAK,CAAC,OAAO,IAAI,CAAC,GAAG,CAAC,UAAU,EAAE,EAAE,CAAC,EAAE,CAAC;IAE/F,IAAI,CAAC;QACH,MAAM,GAAG,GAAG,MAAM,KAAK,CAAC,GAAG,EAAE;YAC3B,OAAO,EAAE,EAAE,MAAM,EAAE,WAAW,EAAE;YAChC,MAAM,EAAE,WAAW,CAAC,OAAO,CAAC,KAAK,CAAC;SACnC,CAAC,CAAC;QAEH,IAAI,CAAC,GAAG,CAAC,EAAE,EAAE,CAAC;YACZ,OAAO,eAAe,CAAC,KAAK,EAAE,UAAU,CAAC,CAAC;QAC5C,CAAC;QAED,MAAM,IAAI,GAAG,MAAM,GAAG,CAAC,IAAI,EAAE,CAAC;QAE9B,wDAAwD;QACxD,MAAM,OAAO,GAAuB,EAAE,CAAC;QACvC,MAAM,eAAe,GAAG,6CAA6C,CAAC;QACtE,IAAI,KAAK,CAAC;QAEV,OACE,CAAC,KAAK,GAAG,eAAe,CAAC,IAAI,CAAC,IAAI,CAAC,CAAC,KAAK,IAAI;YAC7C,OAAO,CAAC,MAAM,GAAG,UAAU,EAC3B,CAAC;YACD,MAAM,IAAI,GAAG,KAAK,CAAC,CAAC,CAAE,CAAC;YACvB,MAAM,IAAI,GAAG,KAAK,CAAC,CAAC,CAAE,CAAC,WAAW,EAAE,CAAC;YACrC,MAAM,KAAK,GAAG,KAAK,CAAC,CAAC,CAAE,CAAC,IAAI,EAAE,CAAC;YAE/B,IAAI,OAAO,CAAC,IAAI,CAAC,CAAC,CAAC,EAAE,EAAE,CAAC,CAAC,CAAC,EAAE,KAAK,IAAI,CAAC;gBAAE,SAAS;YAEjD,OAAO,CAAC,IAAI,CAAC;gBACX,EAAE,EAAE,IAAI;gBACR,MAAM,EAAE,SAAkB;gBAC1B,KAAK,EAAE,IAAI,IAAI,KAAK,KAAK,EAAE;gBAC3B,OAAO,EAAE,CAAC,0DAA0D,CAAC;gBACrE,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;gBACzC,UAAU,EAAE,YAAY;gBACxB,QAAQ,EAAE,6BAA6B,IAAI,oBAAoB,KAAK,2JAA2J;gBAC/N,GAAG,EAAE,0BAA0B,IAAI,EAAE;aACtC,CAAC,CAAC;QACL,CAAC;QAED,0CAA0C;QAC1C,MAAM,gBAAgB,GACpB,gEAAgE,CAAC;QACnE,OACE,CAAC,KAAK,GAAG,gBAAgB,CAAC,IAAI,CAAC,IAAI,CAAC,CAAC,KAAK,IAAI;YAC9C,OAAO,CAAC,MAAM,GAAG,UAAU,EAC3B,CAAC;YACD,MAAM,IAAI,GAAG,KAAK,CAAC,CAAC,CAAE,CAAC;YACvB,MAAM,GAAG,GAAG,KAAK,CAAC,CAAC,CAAE,CAAC;YACtB,MAAM,KAAK,GAAG,KAAK,CAAC,CAAC,CAAE,CAAC,IAAI,EAAE,CAAC;YAE/B,IAAI,OAAO,CAAC,IAAI,CAAC,CAAC,CAAC,EAAE,EAAE,CAAC,CAAC,CAAC,EAAE,KAAK,GAAG,CAAC;gBAAE,SAAS;YAEhD,OAAO,CAAC,IAAI,CAAC;gBACX,EAAE,EAAE,GAAG;gBACP,MAAM,EAAE,SAAkB;gBAC1B,KAAK,EAAE,oBAAoB,KAAK,EAAE;gBAClC,OAAO,EAAE,CAAC,0DAA0D,CAAC;gBACrE,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;gBACzC,UAAU,EAAE,YAAY;gBACxB,QAAQ,EAAE,kCAAkC,GAAG,qBAAqB,KAAK,IAAI;gBAC7E,GAAG,EAAE,0BAA0B,IAAI,EAAE;aACtC,CAAC,CAAC;QACL,CAAC;QAED,IAAI,OAAO,CAAC,MAAM,GAAG,CAAC;YAAE,OAAO,OAAO,CAAC;QACvC,OAAO,eAAe,CAAC,KAAK,EAAE,UAAU,CAAC,CAAC;IAC5C,CAAC;IAAC,MAAM,CAAC;QACP,OAAO,eAAe,CAAC,KAAK,EAAE,UAAU,CAAC,CAAC;IAC5C,CAAC;AACH,CAAC;AAED,SAAS,eAAe,CACtB,KAAa,EACb,UAAkB;IAElB,OAAO;QACL;YACE,EAAE,EAAE,gBAAgB;YACpB,MAAM,EAAE,SAAkB;YAC1B,KAAK,EAAE,yBAAyB,KAAK,EAAE;YACvC,OAAO,EAAE,CAAC,0DAA0D,CAAC;YACrE,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;YACzC,UAAU,EAAE,YAAY;YACxB,QAAQ,EAAE,qDAAqD,KAAK,iFAAiF;YACrJ,GAAG,EAAE,oCAAoC,kBAAkB,CAAC,KAAK,CAAC,EAAE;SACrE;KACF,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC;AACzB,CAAC"}

package/dist/providers/direct/tlv.js

@@ -3,7 +3,7 @@ export async function fetchTlv(query, maxResults) {
         {
             title: `TLV Sweden Decisions: ${query}`,
             abstract: `TLV (Tandvårds- och läkemedelsförmånsverket — Dental and Pharmaceutical Benefits Agency) makes reimbursement decisions for drugs in Sweden's pharmaceutical benefits scheme (LFN). Each decision includes clinical assessment, health economic evaluation, and reimbursement conditions. Search "${query}" to find TLV decisions relevant to the drug or indication. Key for Swedish market access and Nordic HTA benchmarking.`,
-            url: `https://www.tlv.se/in-english/search.html?query=${encodeURIComponent(query)}`,
+            url: `https://www.tlv.se/beslut/sok-i-databasen.html?q=${encodeURIComponent(query)}`,
         },
         {
             title: `TLV General Guidelines for Economic Evaluations`,

package/dist/providers/direct/tlv.js.map

@@ -1 +1 @@
-{"version":3,"file":"tlv.js","sourceRoot":"","sources":["../../../src/providers/direct/tlv.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,QAAQ,CAC5B,KAAa,EACb,UAAkB;IAElB,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,yBAAyB,KAAK,EAAE;YACvC,QAAQ,EAAE,oSAAoS,KAAK,wHAAwH;YAC3a,GAAG,EAAE,mDAAmD,kBAAkB,CAAC,KAAK,CAAC,EAAE;SACpF;QACD;YACE,KAAK,EAAE,iDAAiD;YACxD,QAAQ,EAAE,gaAAga;YAC1a,GAAG,EAAE,0FAA0F;SAChG;QACD;YACE,KAAK,EAAE,mCAAmC;YAC1C,QAAQ,EAAE,qWAAqW;YAC/W,GAAG,EAAE,6CAA6C;SACnD;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,OAAO,CAAC,EAAE;QACd,MAAM,EAAE,KAAc;QACtB,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE;YACP,kGAAkG;SACnG;QACD,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}
+{"version":3,"file":"tlv.js","sourceRoot":"","sources":["../../../src/providers/direct/tlv.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,QAAQ,CAC5B,KAAa,EACb,UAAkB;IAElB,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,yBAAyB,KAAK,EAAE;YACvC,QAAQ,EAAE,oSAAoS,KAAK,wHAAwH;YAC3a,GAAG,EAAE,oDAAoD,kBAAkB,CAAC,KAAK,CAAC,EAAE;SACrF;QACD;YACE,KAAK,EAAE,iDAAiD;YACxD,QAAQ,EAAE,gaAAga;YAC1a,GAAG,EAAE,0FAA0F;SAChG;QACD;YACE,KAAK,EAAE,mCAAmC;YAC1C,QAAQ,EAAE,qWAAqW;YAC/W,GAAG,EAAE,6CAA6C;SACnD;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,OAAO,CAAC,EAAE;QACd,MAAM,EAAE,KAAc;QACtB,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE;YACP,kGAAkG;SACnG;QACD,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}

package/dist/providers/types.d.ts

@@ -24,6 +24,7 @@ export interface LiteratureSearchParams {
     study_types?: StudyType[];
     output_format?: OutputFormat;
     project?: string;
+    runs?: number;
 }
 export interface CEModelParams {
     intervention: string;
@@ -117,6 +118,11 @@ export interface PSASummary {
         prob_ce: number;
     }>;
     evpi: number;
+    evppi: Array<{
+        parameter: string;
+        evppi: number;
+        evppi_proportion: number;
+    }>;
     scatter: Array<{
         delta_cost: number;
         delta_qaly: number;

package/dist/providers/types.d.ts.map

@@ -1 +1 @@
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package/dist/server.js

@@ -16,6 +16,12 @@ import { handleKnowledgeRead, knowledgeReadToolSchema, } from "./tools/knowledge
 import { handleKnowledgeWrite, knowledgeWriteToolSchema, } from "./tools/knowledgeWrite.js";
 import { handleProjectCreate, projectCreateToolSchema, } from "./tools/projectCreate.js";
 import { handleEvidenceNetwork, evidenceNetworkToolSchema, } from "./tools/evidenceNetwork.js";
+import { handleIndirectComparison, indirectComparisonToolSchema, } from "./tools/indirectComparison.js";
+import { handleBudgetImpactModel, budgetImpactModelToolSchema, } from "./tools/budgetImpactModel.js";
+import { handlePopulationAdjustedComparison, populationAdjustedComparisonToolSchema, } from "./tools/populationAdjustedComparison.js";
+import { handleSurvivalFitting, survivalFittingToolSchema, } from "./tools/survivalFitting.js";
+import { handleScreenAbstracts, screenAbstractsToolSchema, } from "./tools/screenAbstracts.js";
+import { handleValidateLinks, validateLinksToolSchema, } from "./tools/validateLinks.js";
 import { randomUUID } from "node:crypto";
 import { trackToolCall, trackSession, shutdownAnalytics } from "./analytics.js";
 import { createServer } from "node:http";
@@ -32,6 +38,12 @@ function createMcpServer() {
             knowledgeWriteToolSchema,
             projectCreateToolSchema,
             evidenceNetworkToolSchema,
+            indirectComparisonToolSchema,
+            budgetImpactModelToolSchema,
+            populationAdjustedComparisonToolSchema,
+            survivalFittingToolSchema,
+            screenAbstractsToolSchema,
+            validateLinksToolSchema,
         ],
     }));
     server.setRequestHandler(CallToolRequestSchema, async (request) => {
@@ -64,6 +76,24 @@ function createMcpServer() {
                 case "evidence_network":
                     result = await handleEvidenceNetwork(args);
                     break;
+                case "indirect_comparison":
+                    result = await handleIndirectComparison(args);
+                    break;
+                case "budget_impact_model":
+                    result = await handleBudgetImpactModel(args);
+                    break;
+                case "population_adjusted_comparison":
+                    result = await handlePopulationAdjustedComparison(args);
+                    break;
+                case "survival_fitting":
+                    result = await handleSurvivalFitting(args);
+                    break;
+                case "screen_abstracts":
+                    result = await handleScreenAbstracts(args);
+                    break;
+                case "validate_links":
+                    result = await handleValidateLinks(args);
+                    break;
                 default:
                     trackToolCall(name, Date.now() - callStart, "error");
                     return {
@@ -100,14 +130,44 @@ async function runStdio() {
     console.error("HEORAgent MCP server running on stdio");
 }
 // --- HTTP mode (--http flag or MCP_HTTP_PORT env) ---
+// --- Session management with TTL and limits ---
+const MAX_SESSIONS = parseInt(process.env.MCP_MAX_SESSIONS ?? "100", 10);
+const SESSION_TTL_MS = parseInt(process.env.MCP_SESSION_TTL_MS ?? String(30 * 60 * 1000), 10); // 30 min default
+const sessions = {};
+function evictStaleSessions() {
+    const now = Date.now();
+    for (const [id, session] of Object.entries(sessions)) {
+        if (now - session.lastActivity > SESSION_TTL_MS) {
+            session.transport.close?.();
+            delete sessions[id];
+            trackSession("session_end", id, { reason: "ttl_eviction" });
+        }
+    }
+}
+// Periodic eviction every 5 minutes
+const evictionInterval = setInterval(evictStaleSessions, 5 * 60 * 1000);
+evictionInterval.unref(); // don't prevent process exit
 async function runHttp(port) {
-    const sessions = {};
     const __dirname = dirname(fileURLToPath(import.meta.url));
+    // Allowed CORS origins (comma-separated env var, or "*" for dev)
+    const allowedOrigins = (process.env.MCP_CORS_ORIGINS ?? "*")
+        .split(",")
+        .map((s) => s.trim());
+    // Optional bearer token for authentication
+    const authToken = process.env.MCP_AUTH_TOKEN;
     const httpServer = createServer(async (req, res) => {
-        // CORS headers
-        res.setHeader("Access-Control-Allow-Origin", "*");
+        // CORS headers — restrict to allowed origins
+        const origin = req.headers.origin ?? "";
+        const corsOrigin = allowedOrigins.includes("*")
+            ? "*"
+            : allowedOrigins.includes(origin)
+                ? origin
+                : "";
+        if (corsOrigin) {
+            res.setHeader("Access-Control-Allow-Origin", corsOrigin);
+        }
         res.setHeader("Access-Control-Allow-Methods", "GET, POST, DELETE, OPTIONS");
-        res.setHeader("Access-Control-Allow-Headers", "Content-Type, mcp-session-id");
+        res.setHeader("Access-Control-Allow-Headers", "Content-Type, mcp-session-id, Authorization");
         res.setHeader("Access-Control-Expose-Headers", "mcp-session-id");
         if (req.method === "OPTIONS") {
             res.writeHead(204);
@@ -141,6 +201,15 @@ async function runHttp(port) {
         }
         // MCP endpoint
         if (req.url === "/mcp") {
+            // Auth check (if MCP_AUTH_TOKEN is set)
+            if (authToken) {
+                const authHeader = req.headers.authorization ?? "";
+                if (authHeader !== `Bearer ${authToken}`) {
+                    res.writeHead(401, { "Content-Type": "application/json" });
+                    res.end(JSON.stringify({ error: "Unauthorized" }));
+                    return;
+                }
+            }
             const sessionId = req.headers["mcp-session-id"];
             if (req.method === "POST") {
                 // Parse body
@@ -151,20 +220,30 @@ async function runHttp(port) {
                 const body = JSON.parse(Buffer.concat(chunks).toString());
                 let transport;
                 if (sessionId && sessions[sessionId]) {
-                    transport = sessions[sessionId];
+                    sessions[sessionId].lastActivity = Date.now();
+                    transport = sessions[sessionId].transport;
                 }
                 else if (!sessionId && body?.method === "initialize") {
+                    // Enforce session limit
+                    evictStaleSessions();
+                    if (Object.keys(sessions).length >= MAX_SESSIONS) {
+                        res.writeHead(503, { "Content-Type": "application/json" });
+                        res.end(JSON.stringify({
+                            error: "Too many active sessions. Try again later.",
+                        }));
+                        return;
+                    }
                     // New session
                     const server = createMcpServer();
                     transport = new StreamableHTTPServerTransport({
                         sessionIdGenerator: () => randomUUID(),
                         onsessioninitialized: (id) => {
-                            sessions[id] = transport;
+                            sessions[id] = { transport, lastActivity: Date.now() };
                             trackSession("session_start", id);
                         },
                     });
                     transport.onclose = () => {
-                        const id = Object.entries(sessions).find(([, t]) => t === transport)?.[0];
+                        const id = Object.entries(sessions).find(([, s]) => s.transport === transport)?.[0];
                         if (id) {
                             trackSession("session_end", id);
                             delete sessions[id];
@@ -186,12 +265,13 @@ async function runHttp(port) {
                     res.end(JSON.stringify({ error: "Invalid session" }));
                     return;
                 }
-                await sessions[sessionId].handleRequest(req, res);
+                sessions[sessionId].lastActivity = Date.now();
+                await sessions[sessionId].transport.handleRequest(req, res);
                 return;
             }
             if (req.method === "DELETE") {
                 if (sessionId && sessions[sessionId]) {
-                    await sessions[sessionId].close();
+                    await sessions[sessionId].transport.close();
                     delete sessions[sessionId];
                 }
                 res.writeHead(200);

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package/dist/tools/budgetImpactModel.d.ts

@@ -0,0 +1,116 @@
+import type { ToolResult } from "../providers/types.js";
+export declare function handleBudgetImpactModel(rawParams: unknown): Promise<ToolResult>;
+export declare const budgetImpactModelToolSchema: {
+    name: string;
+    description: string;
+    inputSchema: {
+        type: string;
+        properties: {
+            intervention: {
+                type: string;
+                description: string;
+            };
+            comparator: {
+                type: string;
+                description: string;
+            };
+            indication: {
+                type: string;
+                description: string;
+            };
+            perspective: {
+                type: string;
+                enum: string[];
+            };
+            time_horizon_years: {
+                type: string;
+                description: string;
+            };
+            eligible_population: {
+                type: string;
+                description: string;
+            };
+            population_growth_rate: {
+                type: string;
+                description: string;
+            };
+            market_share: {
+                type: string;
+                description: string;
+                properties: {
+                    year_1: {
+                        type: string;
+                    };
+                    year_2: {
+                        type: string;
+                    };
+                    year_3: {
+                        type: string;
+                    };
+                    year_4: {
+                        type: string;
+                    };
+                    year_5: {
+                        type: string;
+                    };
+                };
+                required: string[];
+            };
+            drug_cost_annual: {
+                type: string;
+                description: string;
+            };
+            comparator_cost_annual: {
+                type: string;
+                description: string;
+            };
+            admin_cost_annual: {
+                type: string;
+                description: string;
+            };
+            monitoring_cost_annual: {
+                type: string;
+                description: string;
+            };
+            ae_cost_annual: {
+                type: string;
+                description: string;
+            };
+            comparator_ae_cost_annual: {
+                type: string;
+                description: string;
+            };
+            displacement: {
+                type: string;
+                description: string;
+                items: {
+                    type: string;
+                    properties: {
+                        treatment: {
+                            type: string;
+                        };
+                        share: {
+                            type: string;
+                            description: string;
+                        };
+                        cost_annual: {
+                            type: string;
+                            description: string;
+                        };
+                    };
+                    required: string[];
+                };
+            };
+            output_format: {
+                type: string;
+                enum: string[];
+            };
+            project: {
+                type: string;
+                description: string;
+            };
+        };
+        required: string[];
+    };
+};
+//# sourceMappingURL=budgetImpactModel.d.ts.map

package/dist/tools/budgetImpactModel.d.ts.map

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