heor-agent-mcp 0.2.0 → 0.7.0

package/dist/network/frequentistNma.js

@@ -0,0 +1,230 @@
+import { seFromCI, pValueFromZ, poolFixedEffect } from "./bucher.js";
+function isLogScale(measure) {
+    return measure === "OR" || measure === "RR" || measure === "HR";
+}
+function toWorkingScale(d) {
+    const log = isLogScale(d.measure);
+    const se = log
+        ? (Math.log(d.ci_upper) - Math.log(d.ci_lower)) / 3.92
+        : seFromCI(d.ci_lower, d.ci_upper);
+    const value = log ? Math.log(d.estimate) : d.estimate;
+    return { value, se };
+}
+/**
+ * Frequentist contrast-based NMA using weighted least squares.
+ *
+ * Given a set of direct comparisons (possibly multiple per edge),
+ * estimates all pairwise treatment effects relative to a reference.
+ *
+ * For small networks this is equivalent to the graph-theoretical
+ * approach (Rücker 2012).
+ */
+export function frequentistNMA(comparisons, outcome, measure) {
+    // Filter to the specified outcome
+    const relevant = comparisons.filter((c) => c.outcome === outcome && c.measure === measure);
+    if (relevant.length === 0)
+        return [];
+    // Pool direct comparisons by edge (intervention-comparator pair)
+    const edgeKey = (a, b) => [a, b].sort().join("↔");
+    const edgeMap = new Map();
+    for (const d of relevant) {
+        const ws = toWorkingScale(d);
+        const key = edgeKey(d.intervention, d.comparator);
+        if (!edgeMap.has(key)) {
+            edgeMap.set(key, { a: d.intervention, b: d.comparator, studies: [] });
+        }
+        const edge = edgeMap.get(key);
+        // Ensure consistent direction: if stored as B-A but input is A-B
+        if (edge.a === d.comparator && edge.b === d.intervention) {
+            ws.value = -ws.value; // flip direction
+        }
+        edge.studies.push(ws);
+    }
+    // Pool each edge
+    const contrasts = [];
+    for (const edge of edgeMap.values()) {
+        const pooled = poolFixedEffect(edge.studies);
+        contrasts.push({
+            a: edge.a,
+            b: edge.b,
+            value: pooled.value,
+            se: pooled.se,
+            n_studies: pooled.n_studies,
+        });
+    }
+    // Collect all treatment names
+    const treatments = new Set();
+    for (const c of contrasts) {
+        treatments.add(c.a);
+        treatments.add(c.b);
+    }
+    const treatmentList = Array.from(treatments).sort();
+    const n = treatmentList.length;
+    const idx = new Map(treatmentList.map((t, i) => [t, i]));
+    if (n < 2)
+        return [];
+    // Reference treatment = first alphabetically
+    const ref = treatmentList[0];
+    // Build design matrix and weight matrix
+    // Each contrast gives one equation: effect_a - effect_b = observed_value
+    // Parameters: treatment effects relative to reference (n-1 params)
+    const m = contrasts.length; // number of equations
+    const p = n - 1; // number of parameters
+    // X: m x p design matrix
+    // W: m x m diagonal weight matrix (1/se^2)
+    // y: m x 1 observation vector
+    const X = Array.from({ length: m }, () => Array(p).fill(0));
+    const W = new Array(m);
+    const y = new Array(m);
+    for (let i = 0; i < m; i++) {
+        const c = contrasts[i];
+        const ia = idx.get(c.a);
+        const ib = idx.get(c.b);
+        // effect_a - effect_b (relative to reference, which has effect = 0)
+        if (ia > 0)
+            X[i][ia - 1] = 1; // a is not reference
+        if (ib > 0)
+            X[i][ib - 1] = -1; // b is not reference
+        W[i] = 1 / (c.se * c.se);
+        y[i] = c.value;
+    }
+    // Solve: beta = (X'WX)^-1 X'Wy
+    // X'WX is p x p
+    const XtWX = Array.from({ length: p }, () => Array(p).fill(0));
+    const XtWy = Array(p).fill(0);
+    for (let i = 0; i < m; i++) {
+        for (let j = 0; j < p; j++) {
+            XtWy[j] += X[i][j] * W[i] * y[i];
+            for (let k = 0; k < p; k++) {
+                XtWX[j][k] += X[i][j] * W[i] * X[i][k];
+            }
+        }
+    }
+    // Invert XtWX using Gaussian elimination
+    const invXtWX = invertMatrix(XtWX);
+    if (!invXtWX) {
+        // Singular — network is disconnected or underdetermined
+        return [];
+    }
+    // beta = invXtWX * XtWy
+    const beta = Array(p).fill(0);
+    for (let j = 0; j < p; j++) {
+        for (let k = 0; k < p; k++) {
+            beta[j] += invXtWX[j][k] * XtWy[k];
+        }
+    }
+    // SE of each beta: sqrt(diag(invXtWX))
+    const seBeta = Array(p).fill(0);
+    for (let j = 0; j < p; j++) {
+        seBeta[j] = Math.sqrt(invXtWX[j][j]);
+    }
+    // Generate all pairwise comparisons
+    const estimates = [];
+    for (let i = 0; i < n; i++) {
+        for (let j = i + 1; j < n; j++) {
+            const tA = treatmentList[i];
+            const tB = treatmentList[j];
+            // Effect A vs B = effect_A - effect_B (relative to ref)
+            let value;
+            let variance;
+            if (i === 0) {
+                // A is reference: effect = -beta_B
+                value = -beta[j - 1];
+                variance = invXtWX[j - 1][j - 1];
+            }
+            else if (j === 0) {
+                // B is reference: effect = beta_A
+                value = beta[i - 1];
+                variance = invXtWX[i - 1][i - 1];
+            }
+            else {
+                // Neither is reference: effect = beta_A - beta_B
+                value = beta[i - 1] - beta[j - 1];
+                variance =
+                    invXtWX[i - 1][i - 1] +
+                        invXtWX[j - 1][j - 1] -
+                        2 * invXtWX[i - 1][j - 1];
+            }
+            const se = Math.sqrt(Math.max(0, variance));
+            const z = se > 0 ? value / se : 0;
+            const p_value = pValueFromZ(z);
+            let estimate;
+            let ci_lower;
+            let ci_upper;
+            if (isLogScale(measure)) {
+                estimate = Math.exp(value);
+                ci_lower = Math.exp(value - 1.96 * se);
+                ci_upper = Math.exp(value + 1.96 * se);
+            }
+            else {
+                estimate = value;
+                ci_lower = value - 1.96 * se;
+                ci_upper = value + 1.96 * se;
+            }
+            // Check if this is a direct or indirect comparison
+            const directKey = edgeKey(tA, tB);
+            const isDirect = edgeMap.has(directKey);
+            estimates.push({
+                intervention: tA,
+                comparator: tB,
+                commonComparator: isDirect ? "(direct)" : ref,
+                outcome,
+                measure,
+                method: "frequentist_nma",
+                estimate,
+                se,
+                ci_lower,
+                ci_upper,
+                z,
+                p_value,
+                pooled_ab: { value: beta[Math.max(0, i - 1)] ?? 0, se: seBeta[Math.max(0, i - 1)] ?? 0, n_studies: 0 },
+                pooled_bc: { value: beta[Math.max(0, j - 1)] ?? 0, se: seBeta[Math.max(0, j - 1)] ?? 0, n_studies: 0 },
+            });
+        }
+    }
+    return estimates;
+}
+/** Gaussian elimination matrix inversion for small matrices */
+function invertMatrix(matrix) {
+    const n = matrix.length;
+    // Augmented matrix [A | I]
+    const aug = matrix.map((row, i) => {
+        const augRow = [...row];
+        for (let j = 0; j < n; j++) {
+            augRow.push(i === j ? 1 : 0);
+        }
+        return augRow;
+    });
+    for (let col = 0; col < n; col++) {
+        // Find pivot
+        let maxRow = col;
+        let maxVal = Math.abs(aug[col][col]);
+        for (let row = col + 1; row < n; row++) {
+            if (Math.abs(aug[row][col]) > maxVal) {
+                maxVal = Math.abs(aug[row][col]);
+                maxRow = row;
+            }
+        }
+        if (maxVal < 1e-12)
+            return null; // Singular
+        // Swap rows
+        [aug[col], aug[maxRow]] = [aug[maxRow], aug[col]];
+        // Scale pivot row
+        const pivot = aug[col][col];
+        for (let j = 0; j < 2 * n; j++) {
+            aug[col][j] /= pivot;
+        }
+        // Eliminate column
+        for (let row = 0; row < n; row++) {
+            if (row === col)
+                continue;
+            const factor = aug[row][col];
+            for (let j = 0; j < 2 * n; j++) {
+                aug[row][j] -= factor * aug[col][j];
+            }
+        }
+    }
+    // Extract inverse
+    return aug.map((row) => row.slice(n));
+}
+//# sourceMappingURL=frequentistNma.js.map

package/dist/network/frequentistNma.js.map

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package/dist/network/index.d.ts

@@ -1,4 +1,7 @@
 export { extractComparatorPairs, normalizeDrugName } from "./extractor.js";
 export { buildEvidenceNetwork } from "./builder.js";
-export type { EvidenceNode, EvidenceEdge, EvidenceNetwork, NMAFeasibility, NetworkGap, ComparatorPair, } from "./types.js";
+export { computeIndirectComparison, poolFixedEffect } from "./bucher.js";
+export { frequentistNMA } from "./frequentistNma.js";
+export { findIndirectPaths } from "./pathfinder.js";
+export type { EvidenceNode, EvidenceEdge, EvidenceNetwork, NMAFeasibility, NetworkGap, ComparatorPair, DirectComparison, IndirectEstimate, IndirectComparisonResult, IndirectPath, EffectMeasure, PooledEstimate, } from "./types.js";
 //# sourceMappingURL=index.d.ts.map

package/dist/network/index.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"index.d.ts","sourceRoot":"","sources":["../../src/network/index.ts"],"names":[],"mappings":"AAAA,OAAO,EAAE,sBAAsB,EAAE,iBAAiB,EAAE,MAAM,gBAAgB,CAAC;AAC3E,OAAO,EAAE,oBAAoB,EAAE,MAAM,cAAc,CAAC;AACpD,YAAY,EACV,YAAY,EACZ,YAAY,EACZ,eAAe,EACf,cAAc,EACd,UAAU,EACV,cAAc,GACf,MAAM,YAAY,CAAC"}
+{"version":3,"file":"index.d.ts","sourceRoot":"","sources":["../../src/network/index.ts"],"names":[],"mappings":"AAAA,OAAO,EAAE,sBAAsB,EAAE,iBAAiB,EAAE,MAAM,gBAAgB,CAAC;AAC3E,OAAO,EAAE,oBAAoB,EAAE,MAAM,cAAc,CAAC;AACpD,OAAO,EAAE,yBAAyB,EAAE,eAAe,EAAE,MAAM,aAAa,CAAC;AACzE,OAAO,EAAE,cAAc,EAAE,MAAM,qBAAqB,CAAC;AACrD,OAAO,EAAE,iBAAiB,EAAE,MAAM,iBAAiB,CAAC;AACpD,YAAY,EACV,YAAY,EACZ,YAAY,EACZ,eAAe,EACf,cAAc,EACd,UAAU,EACV,cAAc,EACd,gBAAgB,EAChB,gBAAgB,EAChB,wBAAwB,EACxB,YAAY,EACZ,aAAa,EACb,cAAc,GACf,MAAM,YAAY,CAAC"}

package/dist/network/index.js

@@ -1,3 +1,6 @@
 export { extractComparatorPairs, normalizeDrugName } from "./extractor.js";
 export { buildEvidenceNetwork } from "./builder.js";
+export { computeIndirectComparison, poolFixedEffect } from "./bucher.js";
+export { frequentistNMA } from "./frequentistNma.js";
+export { findIndirectPaths } from "./pathfinder.js";
 //# sourceMappingURL=index.js.map

package/dist/network/index.js.map

@@ -1 +1 @@
-{"version":3,"file":"index.js","sourceRoot":"","sources":["../../src/network/index.ts"],"names":[],"mappings":"AAAA,OAAO,EAAE,sBAAsB,EAAE,iBAAiB,EAAE,MAAM,gBAAgB,CAAC;AAC3E,OAAO,EAAE,oBAAoB,EAAE,MAAM,cAAc,CAAC"}
+{"version":3,"file":"index.js","sourceRoot":"","sources":["../../src/network/index.ts"],"names":[],"mappings":"AAAA,OAAO,EAAE,sBAAsB,EAAE,iBAAiB,EAAE,MAAM,gBAAgB,CAAC;AAC3E,OAAO,EAAE,oBAAoB,EAAE,MAAM,cAAc,CAAC;AACpD,OAAO,EAAE,yBAAyB,EAAE,eAAe,EAAE,MAAM,aAAa,CAAC;AACzE,OAAO,EAAE,cAAc,EAAE,MAAM,qBAAqB,CAAC;AACrD,OAAO,EAAE,iBAAiB,EAAE,MAAM,iBAAiB,CAAC"}

package/dist/network/pathfinder.d.ts

@@ -0,0 +1,14 @@
+import type { DirectComparison, IndirectPath } from "./types.js";
+/**
+ * Find all indirect comparison paths through a single common comparator.
+ *
+ * Given comparisons A-B and B-C, returns the path A→B→C allowing
+ * indirect estimation of A vs C.
+ *
+ * If `target` is specified, only returns paths for that specific comparison.
+ */
+export declare function findIndirectPaths(comparisons: DirectComparison[], target?: {
+    intervention: string;
+    comparator: string;
+}): IndirectPath[];
+//# sourceMappingURL=pathfinder.d.ts.map

package/dist/network/pathfinder.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"pathfinder.d.ts","sourceRoot":"","sources":["../../src/network/pathfinder.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,YAAY,EAAE,MAAM,YAAY,CAAC;AAEjE;;;;;;;GAOG;AACH,wBAAgB,iBAAiB,CAC/B,WAAW,EAAE,gBAAgB,EAAE,EAC/B,MAAM,CAAC,EAAE;IAAE,YAAY,EAAE,MAAM,CAAC;IAAC,UAAU,EAAE,MAAM,CAAA;CAAE,GACpD,YAAY,EAAE,CAqGhB"}

package/dist/network/pathfinder.js

@@ -0,0 +1,93 @@
+/**
+ * Find all indirect comparison paths through a single common comparator.
+ *
+ * Given comparisons A-B and B-C, returns the path A→B→C allowing
+ * indirect estimation of A vs C.
+ *
+ * If `target` is specified, only returns paths for that specific comparison.
+ */
+export function findIndirectPaths(comparisons, target) {
+    // Build adjacency: for each treatment pair, collect comparisons
+    const norm = (s) => s.toLowerCase().trim();
+    const pairKey = (a, b) => [norm(a), norm(b)].sort().join("↔");
+    const pairMap = new Map();
+    for (const c of comparisons) {
+        const key = pairKey(c.intervention, c.comparator);
+        if (!pairMap.has(key)) {
+            pairMap.set(key, { a: c.intervention, b: c.comparator, comparisons: [] });
+        }
+        pairMap.get(key).comparisons.push(c);
+    }
+    // Collect all treatments
+    const treatments = new Set();
+    for (const c of comparisons) {
+        treatments.add(norm(c.intervention));
+        treatments.add(norm(c.comparator));
+    }
+    // Build adjacency list
+    const adj = new Map();
+    for (const t of treatments) {
+        adj.set(t, new Set());
+    }
+    for (const pair of pairMap.values()) {
+        const a = norm(pair.a);
+        const b = norm(pair.b);
+        adj.get(a).add(b);
+        adj.get(b).add(a);
+    }
+    const paths = [];
+    const treatmentList = Array.from(treatments);
+    // For each pair (A, C), find all single-bridge paths A-B-C
+    for (let i = 0; i < treatmentList.length; i++) {
+        for (let j = i + 1; j < treatmentList.length; j++) {
+            const a = treatmentList[i];
+            const c = treatmentList[j];
+            // If target is specified, filter
+            if (target) {
+                const tA = norm(target.intervention);
+                const tC = norm(target.comparator);
+                if (!((a === tA && c === tC) || (a === tC && c === tA)))
+                    continue;
+            }
+            // Find bridges: treatments connected to both A and C
+            const neighborsA = adj.get(a);
+            const neighborsC = adj.get(c);
+            for (const bridge of neighborsA) {
+                if (bridge === a || bridge === c)
+                    continue;
+                if (!neighborsC.has(bridge))
+                    continue;
+                // Found a path: A-bridge-C
+                // Get comparisons for A-bridge and C-bridge
+                const abKey = pairKey(a, bridge);
+                const cbKey = pairKey(c, bridge);
+                const abData = pairMap.get(abKey);
+                const cbData = pairMap.get(cbKey);
+                if (abData && cbData) {
+                    // Get original labels (non-normalized)
+                    const labelA = abData.comparisons[0].intervention === a ||
+                        norm(abData.comparisons[0].intervention) === a
+                        ? abData.comparisons[0].intervention
+                        : abData.comparisons[0].comparator;
+                    const labelC = cbData.comparisons[0].intervention === c ||
+                        norm(cbData.comparisons[0].intervention) === c
+                        ? cbData.comparisons[0].intervention
+                        : cbData.comparisons[0].comparator;
+                    const labelBridge = abData.comparisons[0].comparator === bridge ||
+                        norm(abData.comparisons[0].comparator) === bridge
+                        ? abData.comparisons[0].comparator
+                        : abData.comparisons[0].intervention;
+                    paths.push({
+                        a: labelA,
+                        c: labelC,
+                        bridge: labelBridge,
+                        abComparisons: abData.comparisons,
+                        bcComparisons: cbData.comparisons,
+                    });
+                }
+            }
+        }
+    }
+    return paths;
+}
+//# sourceMappingURL=pathfinder.js.map

package/dist/network/pathfinder.js.map

@@ -0,0 +1 @@
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package/dist/network/types.d.ts

@@ -39,4 +39,49 @@ export interface ComparatorPair {
     studyType: string;
     confidence: "high" | "medium" | "low";
 }
+export type EffectMeasure = "MD" | "OR" | "RR" | "HR";
+export interface DirectComparison {
+    intervention: string;
+    comparator: string;
+    outcome: string;
+    measure: EffectMeasure;
+    estimate: number;
+    ci_lower: number;
+    ci_upper: number;
+    source: string;
+}
+export interface PooledEstimate {
+    value: number;
+    se: number;
+    n_studies: number;
+}
+export interface IndirectEstimate {
+    intervention: string;
+    comparator: string;
+    commonComparator: string;
+    outcome: string;
+    measure: EffectMeasure;
+    method: "bucher" | "frequentist_nma";
+    estimate: number;
+    se: number;
+    ci_lower: number;
+    ci_upper: number;
+    z: number;
+    p_value: number;
+    pooled_ab: PooledEstimate;
+    pooled_bc: PooledEstimate;
+}
+export interface IndirectComparisonResult {
+    estimates: IndirectEstimate[];
+    method: "bucher" | "frequentist_nma" | "mixed";
+    warnings: string[];
+    limitations: string[];
+}
+export interface IndirectPath {
+    a: string;
+    c: string;
+    bridge: string;
+    abComparisons: DirectComparison[];
+    bcComparisons: DirectComparison[];
+}
 //# sourceMappingURL=types.d.ts.map

package/dist/network/types.d.ts.map

@@ -1 +1 @@
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+{"version":3,"file":"types.d.ts","sourceRoot":"","sources":["../../src/network/types.ts"],"names":[],"mappings":"AAAA,MAAM,WAAW,YAAY;IAC3B,EAAE,EAAE,MAAM,CAAC;IACX,KAAK,EAAE,MAAM,CAAC;IACd,IAAI,EAAE,cAAc,GAAG,YAAY,CAAC;CACrC;AAED,MAAM,WAAW,YAAY;IAC3B,MAAM,EAAE,MAAM,CAAC;IACf,MAAM,EAAE,MAAM,CAAC;IACf,MAAM,EAAE,MAAM,EAAE,CAAC;IACjB,UAAU,EAAE,MAAM,EAAE,CAAC;IACrB,MAAM,EAAE,OAAO,CAAC;IAChB,UAAU,EAAE,MAAM,GAAG,QAAQ,GAAG,KAAK,CAAC;CACvC;AAED,MAAM,WAAW,UAAU;IACzB,IAAI,EAAE,MAAM,CAAC;IACb,EAAE,EAAE,MAAM,CAAC;IACX,WAAW,EAAE,MAAM,CAAC;CACrB;AAED,MAAM,WAAW,cAAc;IAC7B,QAAQ,EAAE,OAAO,CAAC;IAClB,OAAO,EAAE,MAAM,EAAE,CAAC;IAClB,SAAS,EAAE,MAAM,CAAC;IAClB,SAAS,EAAE,MAAM,CAAC;IAClB,SAAS,EAAE,OAAO,CAAC;IACnB,cAAc,EAAE,MAAM,CAAC;IACvB,UAAU,EAAE,MAAM,EAAE,EAAE,CAAC;IACvB,gBAAgB,EAAE,MAAM,CAAC;IACzB,IAAI,EAAE,UAAU,EAAE,CAAC;CACpB;AAED,MAAM,WAAW,eAAe;IAC9B,KAAK,EAAE,YAAY,EAAE,CAAC;IACtB,KAAK,EAAE,YAAY,EAAE,CAAC;IACtB,WAAW,EAAE,cAAc,CAAC;CAC7B;AAED,MAAM,WAAW,cAAc;IAC7B,YAAY,EAAE,MAAM,CAAC;IACrB,UAAU,EAAE,MAAM,CAAC;IACnB,OAAO,EAAE,MAAM,CAAC;IAChB,SAAS,EAAE,MAAM,CAAC;IAClB,UAAU,EAAE,MAAM,GAAG,QAAQ,GAAG,KAAK,CAAC;CACvC;AAID,MAAM,MAAM,aAAa,GAAG,IAAI,GAAG,IAAI,GAAG,IAAI,GAAG,IAAI,CAAC;AAEtD,MAAM,WAAW,gBAAgB;IAC/B,YAAY,EAAE,MAAM,CAAC;IACrB,UAAU,EAAE,MAAM,CAAC;IACnB,OAAO,EAAE,MAAM,CAAC;IAChB,OAAO,EAAE,aAAa,CAAC;IACvB,QAAQ,EAAE,MAAM,CAAC;IACjB,QAAQ,EAAE,MAAM,CAAC;IACjB,QAAQ,EAAE,MAAM,CAAC;IACjB,MAAM,EAAE,MAAM,CAAC;CAChB;AAED,MAAM,WAAW,cAAc;IAC7B,KAAK,EAAE,MAAM,CAAC;IACd,EAAE,EAAE,MAAM,CAAC;IACX,SAAS,EAAE,MAAM,CAAC;CACnB;AAED,MAAM,WAAW,gBAAgB;IAC/B,YAAY,EAAE,MAAM,CAAC;IACrB,UAAU,EAAE,MAAM,CAAC;IACnB,gBAAgB,EAAE,MAAM,CAAC;IACzB,OAAO,EAAE,MAAM,CAAC;IAChB,OAAO,EAAE,aAAa,CAAC;IACvB,MAAM,EAAE,QAAQ,GAAG,iBAAiB,CAAC;IACrC,QAAQ,EAAE,MAAM,CAAC;IACjB,EAAE,EAAE,MAAM,CAAC;IACX,QAAQ,EAAE,MAAM,CAAC;IACjB,QAAQ,EAAE,MAAM,CAAC;IACjB,CAAC,EAAE,MAAM,CAAC;IACV,OAAO,EAAE,MAAM,CAAC;IAChB,SAAS,EAAE,cAAc,CAAC;IAC1B,SAAS,EAAE,cAAc,CAAC;CAC3B;AAED,MAAM,WAAW,wBAAwB;IACvC,SAAS,EAAE,gBAAgB,EAAE,CAAC;IAC9B,MAAM,EAAE,QAAQ,GAAG,iBAAiB,GAAG,OAAO,CAAC;IAC/C,QAAQ,EAAE,MAAM,EAAE,CAAC;IACnB,WAAW,EAAE,MAAM,EAAE,CAAC;CACvB;AAED,MAAM,WAAW,YAAY;IAC3B,CAAC,EAAE,MAAM,CAAC;IACV,CAAC,EAAE,MAAM,CAAC;IACV,MAAM,EAAE,MAAM,CAAC;IACf,aAAa,EAAE,gBAAgB,EAAE,CAAC;IAClC,aAAa,EAAE,gBAAgB,EAAE,CAAC;CACnC"}

package/dist/providers/direct/index.d.ts.map

@@ -1 +1 @@
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+{"version":3,"file":"index.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/index.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EACV,SAAS,EACT,sBAAsB,EACtB,aAAa,EACb,aAAa,EACb,UAAU,EAGX,MAAM,aAAa,CAAC;AAgHrB,qBAAa,cAAe,YAAW,SAAS;IACxC,gBAAgB,CAAC,MAAM,EAAE,sBAAsB,GAAG,OAAO,CAAC,UAAU,CAAC;IA+KrE,YAAY,CAAC,OAAO,EAAE,aAAa,GAAG,OAAO,CAAC,UAAU,CAAC;IAMzD,WAAW,CAAC,OAAO,EAAE,aAAa,GAAG,OAAO,CAAC,UAAU,CAAC;CAK/D"}

package/dist/providers/direct/index.js

@@ -121,35 +121,90 @@ export class DirectProvider {
                 audit = addWarning(audit, `${src} requested but ${envVar} is not set and HEOR_PROXY_URL is not configured — ${src} results will be empty.`);
             }
         }
+        const runs = Math.min(Math.max(params.runs ?? 1, 1), 5);
         const allResults = [];
-        for (const source of sources) {
-            const start = Date.now();
-            try {
-                const results = await FETCHERS[source](params.query, maxPerSource);
-                const filtered = params.date_from
-                    ? results.filter((r) => !r.date || r.date >= params.date_from)
-                    : results;
-                audit = addSource(audit, {
-                    source,
-                    query_sent: params.query,
-                    results_returned: results.length,
-                    results_included: filtered.length,
-                    latency_ms: Date.now() - start,
-                    status: "ok",
-                });
-                allResults.push(...filtered);
+        // Track how many runs each result appears in (for stability ranking)
+        const resultFrequency = new Map();
+        for (let run = 0; run < runs; run++) {
+            // Fetch all sources in parallel within each run
+            const fetchPromises = sources.map(async (source) => {
+                const start = Date.now();
+                try {
+                    const results = await FETCHERS[source](params.query, maxPerSource);
+                    const filtered = params.date_from
+                        ? results.filter((r) => !r.date || r.date >= params.date_from)
+                        : results;
+                    return {
+                        source,
+                        results,
+                        filtered,
+                        latency_ms: Date.now() - start,
+                        status: "ok",
+                        error: undefined,
+                    };
+                }
+                catch (err) {
+                    return {
+                        source,
+                        results: [],
+                        filtered: [],
+                        latency_ms: Date.now() - start,
+                        status: "failed",
+                        error: err instanceof Error ? err.message : String(err),
+                    };
+                }
+            });
+            const settled = await Promise.all(fetchPromises);
+            for (const outcome of settled) {
+                if (run === 0) {
+                    if (outcome.status === "ok") {
+                        audit = addSource(audit, {
+                            source: outcome.source,
+                            query_sent: params.query,
+                            results_returned: outcome.results.length,
+                            results_included: outcome.filtered.length,
+                            latency_ms: outcome.latency_ms,
+                            status: "ok",
+                        });
+                    }
+                    else {
+                        audit = addSource(audit, {
+                            source: outcome.source,
+                            query_sent: params.query,
+                            results_returned: 0,
+                            results_included: 0,
+                            latency_ms: outcome.latency_ms,
+                            status: "failed",
+                            error: outcome.error,
+                        });
+                        audit = addWarning(audit, `Source ${outcome.source} failed: ${outcome.error}`);
+                    }
+                }
+                for (const r of outcome.filtered) {
+                    const key = r.id || `${r.source}_${r.title}`;
+                    const freq = (resultFrequency.get(key) ?? 0) + 1;
+                    resultFrequency.set(key, freq);
+                    if (freq === 1) {
+                        allResults.push(r);
+                    }
+                }
             }
-            catch (err) {
-                audit = addSource(audit, {
-                    source,
-                    query_sent: params.query,
-                    results_returned: 0,
-                    results_included: 0,
-                    latency_ms: Date.now() - start,
-                    status: "failed",
-                    error: err instanceof Error ? err.message : String(err),
-                });
-                audit = addWarning(audit, `Source ${source} failed: ${err instanceof Error ? err.message : String(err)}`);
+        }
+        // Sort by stability: results found in more runs ranked higher
+        if (runs > 1) {
+            allResults.sort((a, b) => {
+                const keyA = a.id || `${a.source}_${a.title}`;
+                const keyB = b.id || `${b.source}_${b.title}`;
+                const freqA = resultFrequency.get(keyA) ?? 0;
+                const freqB = resultFrequency.get(keyB) ?? 0;
+                return freqB - freqA; // higher frequency first
+            });
+            audit = addAssumption(audit, `Stability search: ${runs} runs performed, results deduplicated and ranked by consistency (${allResults.length} unique results)`);
+            // Add stability scores to results
+            for (const r of allResults) {
+                const key = r.id || `${r.source}_${r.title}`;
+                const freq = resultFrequency.get(key) ?? 1;
+                r.abstract = `[Stability: ${freq}/${runs} runs] ${r.abstract}`;
             }
         }
         if (params.project && allResults.length > 0) {

package/dist/providers/direct/index.js.map

@@ -1 +1 @@
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package/dist/providers/direct/iqwig.js

@@ -3,7 +3,7 @@ export async function fetchIqwig(query, maxResults) {
         {
             title: `IQWiG Reports Search: ${query}`,
             abstract: `IQWiG (Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen — Institute for Quality and Efficiency in Health Care) produces systematic reviews, health technology assessments, and AMNOG dossier assessments commissioned by G-BA. Search "${query}" to find IQWiG reports on clinical benefit, cost-effectiveness, and evidence quality. IQWiG assessments are foundational to G-BA benefit rating decisions under AMNOG.`,
-            url: `https://www.iqwig.de/en/projects/?tab=search&query=${encodeURIComponent(query)}`,
+            url: `https://www.iqwig.de/en/search/?q=${encodeURIComponent(query)}`,
         },
         {
             title: `IQWiG General Methods v8.0 (2025)`,