ezmedicationinput 0.1.1 → 0.1.3

package/dist/maps.js

@@ -1,26 +1,30 @@
-import { EventTiming, FhirDayOfWeek, FhirPeriodUnit, RouteCode, SNOMEDCTRouteCodes } from "./types";
+"use strict";
+Object.defineProperty(exports, "__esModule", { value: true });
+exports.DEFAULT_UNIT_BY_ROUTE = exports.DEFAULT_UNIT_BY_NORMALIZED_FORM = exports.KNOWN_TMT_DOSAGE_FORM_TO_SNOMED_ROUTE = exports.KNOWN_DOSAGE_FORMS_TO_DOSE = exports.WORD_FREQUENCIES = exports.DAY_OF_WEEK_TOKENS = exports.DISCOURAGED_TOKENS = exports.MEAL_KEYWORDS = exports.EVENT_TIMING_TOKENS = exports.TIMING_ABBREVIATIONS = exports.DEFAULT_UNIT_SYNONYMS = exports.HOUSEHOLD_VOLUME_UNITS = exports.DEFAULT_ROUTE_SYNONYMS = exports.ROUTE_BY_SNOMED = exports.ROUTE_TEXT = exports.ROUTE_SNOMED = void 0;
+const types_1 = require("./types");
+const object_1 = require("./utils/object");
 const ROUTE_TEXT_OVERRIDES = {
-    [RouteCode["Oral route"]]: "by mouth",
-    [RouteCode["Sublingual route"]]: "sublingual",
-    [RouteCode["Buccal route"]]: "buccal",
-    [RouteCode["Respiratory tract route (qualifier value)"]]: "inhalation",
-    [RouteCode["Nasal route"]]: "intranasal",
-    [RouteCode["Topical route"]]: "topical",
-    [RouteCode["Transdermal route"]]: "transdermal",
-    [RouteCode["Subcutaneous route"]]: "subcutaneous",
-    [RouteCode["Intramuscular route"]]: "intramuscular",
-    [RouteCode["Intravenous route"]]: "intravenous",
-    [RouteCode["Per rectum"]]: "rectal",
-    [RouteCode["Per vagina"]]: "vaginal",
-    [RouteCode["Ophthalmic route"]]: "ophthalmic",
-    [RouteCode["Intravitreal route (qualifier value)"]]: "intravitreal"
+    [types_1.RouteCode["Oral route"]]: "by mouth",
+    [types_1.RouteCode["Sublingual route"]]: "sublingual",
+    [types_1.RouteCode["Buccal route"]]: "buccal",
+    [types_1.RouteCode["Respiratory tract route (qualifier value)"]]: "inhalation",
+    [types_1.RouteCode["Nasal route"]]: "intranasal",
+    [types_1.RouteCode["Topical route"]]: "topical",
+    [types_1.RouteCode["Transdermal route"]]: "transdermal",
+    [types_1.RouteCode["Subcutaneous route"]]: "subcutaneous",
+    [types_1.RouteCode["Intramuscular route"]]: "intramuscular",
+    [types_1.RouteCode["Intravenous route"]]: "intravenous",
+    [types_1.RouteCode["Per rectum"]]: "rectal",
+    [types_1.RouteCode["Per vagina"]]: "vaginal",
+    [types_1.RouteCode["Ophthalmic route"]]: "ophthalmic",
+    [types_1.RouteCode["Intravitreal route (qualifier value)"]]: "intravitreal"
 };
 function defaultRouteText(display) {
     const cleaned = display.replace(/\s*\(qualifier value\)/gi, "");
     const withoutSuffix = cleaned.replace(/\b(route|use)\b/gi, "");
     return withoutSuffix.replace(/\s+/g, " ").trim().toLowerCase();
 }
-const ROUTE_SNOMED_ENTRIES = Object.entries(SNOMEDCTRouteCodes).map(([display, code]) => {
+const ROUTE_SNOMED_ENTRIES = (0, object_1.objectEntries)(types_1.SNOMEDCTRouteCodes).map(([display, code]) => {
     const routeCode = code;
     return [
         routeCode,
@@ -32,17 +36,20 @@ const ROUTE_SNOMED_ENTRIES = Object.entries(SNOMEDCTRouteCodes).map(([display, c
  * data-driven ensures any additions to the enumeration are surfaced
  * automatically throughout the library.
  */
-export const ROUTE_SNOMED = Object.fromEntries(ROUTE_SNOMED_ENTRIES);
-export const ROUTE_TEXT = Object.fromEntries(ROUTE_SNOMED_ENTRIES.map(([routeCode, meta]) => [
-    routeCode,
-    ROUTE_TEXT_OVERRIDES[routeCode] ?? defaultRouteText(meta.display)
-]));
+exports.ROUTE_SNOMED = (0, object_1.objectFromEntries)(ROUTE_SNOMED_ENTRIES);
+exports.ROUTE_TEXT = (0, object_1.objectFromEntries)(ROUTE_SNOMED_ENTRIES.map(([routeCode, meta]) => {
+    var _a;
+    return [
+        routeCode,
+        (_a = ROUTE_TEXT_OVERRIDES[routeCode]) !== null && _a !== void 0 ? _a : defaultRouteText(meta.display)
+    ];
+}));
 /**
  * Inverse lookup so that SNOMED codes flowing in from FHIR can be mapped back
  * into our internal RouteCode abstraction during round-tripping.
  */
-export const ROUTE_BY_SNOMED = Object.fromEntries(ROUTE_SNOMED_ENTRIES.map(([routeCode, meta]) => [meta.code, routeCode]));
-export const DEFAULT_ROUTE_SYNONYMS = (() => {
+exports.ROUTE_BY_SNOMED = (0, object_1.objectFromEntries)(ROUTE_SNOMED_ENTRIES.map(([routeCode, meta]) => [meta.code, routeCode]));
+exports.DEFAULT_ROUTE_SYNONYMS = (() => {
     const map = {};
     const assign = (key, code) => {
         if (!key)
@@ -51,7 +58,7 @@ export const DEFAULT_ROUTE_SYNONYMS = (() => {
         if (!normalized || map[normalized]) {
             return;
         }
-        map[normalized] = { code, text: ROUTE_TEXT[code] };
+        map[normalized] = { code, text: exports.ROUTE_TEXT[code] };
     };
     const registerVariants = (value, code) => {
         if (!value)
@@ -73,51 +80,51 @@ export const DEFAULT_ROUTE_SYNONYMS = (() => {
             .trim();
         assign(withoutPunctuation, code);
     };
-    registerVariants("po", RouteCode["Oral route"]);
-    registerVariants("oral", RouteCode["Oral route"]);
-    registerVariants("by mouth", RouteCode["Oral route"]);
-    registerVariants("per os", RouteCode["Oral route"]);
-    registerVariants("sl", RouteCode["Sublingual route"]);
-    registerVariants("s.l.", RouteCode["Sublingual route"]);
-    registerVariants("sublingual", RouteCode["Sublingual route"]);
-    registerVariants("buccal", RouteCode["Buccal route"]);
-    registerVariants("inh", RouteCode["Respiratory tract route (qualifier value)"]);
-    registerVariants("inhalation", RouteCode["Respiratory tract route (qualifier value)"]);
-    registerVariants("inhaled", RouteCode["Respiratory tract route (qualifier value)"]);
-    registerVariants("iv", RouteCode["Intravenous route"]);
-    registerVariants("ivp", RouteCode["Intravenous route"]);
-    registerVariants("ivpb", RouteCode["Intravenous route"]);
-    registerVariants("iv push", RouteCode["Intravenous route"]);
-    registerVariants("iv bolus", RouteCode["Intravenous route"]);
-    registerVariants("iv drip", RouteCode["Intravenous route"]);
-    registerVariants("intravenous", RouteCode["Intravenous route"]);
-    registerVariants("im", RouteCode["Intramuscular route"]);
-    registerVariants("im injection", RouteCode["Intramuscular route"]);
-    registerVariants("intramuscular", RouteCode["Intramuscular route"]);
-    registerVariants("sc", RouteCode["Subcutaneous route"]);
-    registerVariants("sq", RouteCode["Subcutaneous route"]);
-    registerVariants("subq", RouteCode["Subcutaneous route"]);
-    registerVariants("subcut", RouteCode["Subcutaneous route"]);
-    registerVariants("subcutaneous", RouteCode["Subcutaneous route"]);
-    registerVariants("in", RouteCode["Nasal route"]);
-    registerVariants("intranasal", RouteCode["Nasal route"]);
-    registerVariants("nasal", RouteCode["Nasal route"]);
-    registerVariants("top", RouteCode["Topical route"]);
-    registerVariants("topical", RouteCode["Topical route"]);
-    registerVariants("td", RouteCode["Transdermal route"]);
-    registerVariants("patch", RouteCode["Transdermal route"]);
-    registerVariants("transdermal", RouteCode["Transdermal route"]);
-    registerVariants("pr", RouteCode["Per rectum"]);
-    registerVariants("rectal", RouteCode["Per rectum"]);
-    registerVariants("pv", RouteCode["Per vagina"]);
-    registerVariants("vaginal", RouteCode["Per vagina"]);
-    registerVariants("oph", RouteCode["Ophthalmic route"]);
-    registerVariants("ophth", RouteCode["Ophthalmic route"]);
-    registerVariants("ophthalmic", RouteCode["Ophthalmic route"]);
-    registerVariants("ocular", RouteCode["Ophthalmic route"]);
-    registerVariants("intravitreal", RouteCode["Intravitreal route (qualifier value)"]);
-    registerVariants("intravitreal injection", RouteCode["Intravitreal route (qualifier value)"]);
-    registerVariants("ivt", RouteCode["Intravitreal route (qualifier value)"]);
+    registerVariants("po", types_1.RouteCode["Oral route"]);
+    registerVariants("oral", types_1.RouteCode["Oral route"]);
+    registerVariants("by mouth", types_1.RouteCode["Oral route"]);
+    registerVariants("per os", types_1.RouteCode["Oral route"]);
+    registerVariants("sl", types_1.RouteCode["Sublingual route"]);
+    registerVariants("s.l.", types_1.RouteCode["Sublingual route"]);
+    registerVariants("sublingual", types_1.RouteCode["Sublingual route"]);
+    registerVariants("buccal", types_1.RouteCode["Buccal route"]);
+    registerVariants("inh", types_1.RouteCode["Respiratory tract route (qualifier value)"]);
+    registerVariants("inhalation", types_1.RouteCode["Respiratory tract route (qualifier value)"]);
+    registerVariants("inhaled", types_1.RouteCode["Respiratory tract route (qualifier value)"]);
+    registerVariants("iv", types_1.RouteCode["Intravenous route"]);
+    registerVariants("ivp", types_1.RouteCode["Intravenous route"]);
+    registerVariants("ivpb", types_1.RouteCode["Intravenous route"]);
+    registerVariants("iv push", types_1.RouteCode["Intravenous route"]);
+    registerVariants("iv bolus", types_1.RouteCode["Intravenous route"]);
+    registerVariants("iv drip", types_1.RouteCode["Intravenous route"]);
+    registerVariants("intravenous", types_1.RouteCode["Intravenous route"]);
+    registerVariants("im", types_1.RouteCode["Intramuscular route"]);
+    registerVariants("im injection", types_1.RouteCode["Intramuscular route"]);
+    registerVariants("intramuscular", types_1.RouteCode["Intramuscular route"]);
+    registerVariants("sc", types_1.RouteCode["Subcutaneous route"]);
+    registerVariants("sq", types_1.RouteCode["Subcutaneous route"]);
+    registerVariants("subq", types_1.RouteCode["Subcutaneous route"]);
+    registerVariants("subcut", types_1.RouteCode["Subcutaneous route"]);
+    registerVariants("subcutaneous", types_1.RouteCode["Subcutaneous route"]);
+    registerVariants("in", types_1.RouteCode["Nasal route"]);
+    registerVariants("intranasal", types_1.RouteCode["Nasal route"]);
+    registerVariants("nasal", types_1.RouteCode["Nasal route"]);
+    registerVariants("top", types_1.RouteCode["Topical route"]);
+    registerVariants("topical", types_1.RouteCode["Topical route"]);
+    registerVariants("td", types_1.RouteCode["Transdermal route"]);
+    registerVariants("patch", types_1.RouteCode["Transdermal route"]);
+    registerVariants("transdermal", types_1.RouteCode["Transdermal route"]);
+    registerVariants("pr", types_1.RouteCode["Per rectum"]);
+    registerVariants("rectal", types_1.RouteCode["Per rectum"]);
+    registerVariants("pv", types_1.RouteCode["Per vagina"]);
+    registerVariants("vaginal", types_1.RouteCode["Per vagina"]);
+    registerVariants("oph", types_1.RouteCode["Ophthalmic route"]);
+    registerVariants("ophth", types_1.RouteCode["Ophthalmic route"]);
+    registerVariants("ophthalmic", types_1.RouteCode["Ophthalmic route"]);
+    registerVariants("ocular", types_1.RouteCode["Ophthalmic route"]);
+    registerVariants("intravitreal", types_1.RouteCode["Intravitreal route (qualifier value)"]);
+    registerVariants("intravitreal injection", types_1.RouteCode["Intravitreal route (qualifier value)"]);
+    registerVariants("ivt", types_1.RouteCode["Intravitreal route (qualifier value)"]);
     for (const [routeCode, meta] of ROUTE_SNOMED_ENTRIES) {
         const display = meta.display.toLowerCase();
         registerVariants(display, routeCode);
@@ -133,7 +140,92 @@ export const DEFAULT_ROUTE_SYNONYMS = (() => {
     }
     return map;
 })();
-export const DEFAULT_UNIT_SYNONYMS = {
+const UNIT_PREFIXES = [
+    { canonical: "", abbreviations: [""], names: [{ singular: "", plural: "" }] },
+    {
+        canonical: "m",
+        abbreviations: ["m"],
+        names: [{ singular: "milli", plural: "milli" }],
+    },
+    {
+        canonical: "mc",
+        abbreviations: ["mc", "µ", "μ", "u"],
+        names: [{ singular: "micro", plural: "micro" }],
+    },
+    {
+        canonical: "n",
+        abbreviations: ["n"],
+        names: [{ singular: "nano", plural: "nano" }],
+    },
+    {
+        canonical: "k",
+        abbreviations: ["k"],
+        names: [{ singular: "kilo", plural: "kilo" }],
+    },
+];
+const METRIC_UNIT_BASES = [
+    {
+        canonical: "g",
+        abbreviations: ["g"],
+        names: [
+            { singular: "gram", plural: "grams" },
+            { singular: "gramme", plural: "grammes" },
+        ],
+    },
+    {
+        canonical: "L",
+        abbreviations: ["l"],
+        names: [
+            { singular: "liter", plural: "liters" },
+            { singular: "litre", plural: "litres" },
+        ],
+    },
+];
+function assignUnitSynonym(map, key, canonical) {
+    const normalized = key.trim().toLowerCase();
+    if (!normalized || map[normalized]) {
+        return;
+    }
+    map[normalized] = canonical;
+}
+function addMetricUnitSynonyms(map) {
+    for (const prefix of UNIT_PREFIXES) {
+        for (const base of METRIC_UNIT_BASES) {
+            const canonical = `${prefix.canonical}${base.canonical}`;
+            for (const prefixAbbrev of prefix.abbreviations) {
+                for (const baseAbbrev of base.abbreviations) {
+                    if (!baseAbbrev) {
+                        continue;
+                    }
+                    const token = `${prefixAbbrev}${baseAbbrev}`;
+                    assignUnitSynonym(map, token, canonical);
+                    assignUnitSynonym(map, `${token}s`, canonical);
+                    if (token.endsWith(".")) {
+                        assignUnitSynonym(map, token.replace(/\.+$/, ""), canonical);
+                    }
+                }
+            }
+            for (const prefixName of prefix.names) {
+                for (const baseName of base.names) {
+                    const singular = `${prefixName.singular}${baseName.singular}`;
+                    const plural = `${prefixName.singular}${baseName.plural}`;
+                    const hyphenSingular = prefixName.singular
+                        ? `${prefixName.singular}-${baseName.singular}`
+                        : baseName.singular;
+                    const hyphenPlural = prefixName.singular
+                        ? `${prefixName.singular}-${baseName.plural}`
+                        : baseName.plural;
+                    assignUnitSynonym(map, singular, canonical);
+                    assignUnitSynonym(map, plural, canonical);
+                    assignUnitSynonym(map, hyphenSingular, canonical);
+                    assignUnitSynonym(map, hyphenPlural, canonical);
+                }
+            }
+        }
+    }
+}
+exports.HOUSEHOLD_VOLUME_UNITS = ["tsp", "tbsp"];
+const STATIC_UNIT_SYNONYMS = {
     tab: "tab",
     tabs: "tab",
     tablet: "tab",
@@ -142,13 +234,6 @@ export const DEFAULT_UNIT_SYNONYMS = {
     caps: "cap",
     capsule: "cap",
     capsules: "cap",
-    ml: "mL",
-    "milliliter": "mL",
-    "milliliters": "mL",
-    mg: "mg",
-    g: "g",
-    mcg: "mcg",
-    ug: "mcg",
     puff: "puff",
     puffs: "puff",
     spray: "spray",
@@ -159,144 +244,195 @@ export const DEFAULT_UNIT_SYNONYMS = {
     patches: "patch",
     supp: "suppository",
     suppository: "suppository",
-    suppositories: "suppository"
+    suppositories: "suppository",
+    tsp: "tsp",
+    "tsp.": "tsp",
+    tsps: "tsp",
+    "tsps.": "tsp",
+    teaspoon: "tsp",
+    teaspoons: "tsp",
+    tbsp: "tbsp",
+    "tbsp.": "tbsp",
+    tbs: "tbsp",
+    "tbs.": "tbsp",
+    tablespoon: "tbsp",
+    tablespoons: "tbsp",
 };
-export const TIMING_ABBREVIATIONS = {
+exports.DEFAULT_UNIT_SYNONYMS = (() => {
+    const map = Object.assign({}, STATIC_UNIT_SYNONYMS);
+    addMetricUnitSynonyms(map);
+    return map;
+})();
+exports.TIMING_ABBREVIATIONS = {
     qd: {
         code: "QD",
         frequency: 1,
         period: 1,
-        periodUnit: FhirPeriodUnit.Day,
+        periodUnit: types_1.FhirPeriodUnit.Day,
         discouraged: "QD"
     },
     qod: {
         code: "QOD",
         period: 2,
-        periodUnit: FhirPeriodUnit.Day,
+        periodUnit: types_1.FhirPeriodUnit.Day,
         discouraged: "QOD"
     },
+    od: {
+        code: "QD",
+        frequency: 1,
+        period: 1,
+        periodUnit: types_1.FhirPeriodUnit.Day
+    },
     ad: {
         period: 2,
-        periodUnit: FhirPeriodUnit.Day,
+        periodUnit: types_1.FhirPeriodUnit.Day,
         discouraged: "AD"
     },
     bid: {
         code: "BID",
         frequency: 2,
         period: 1,
-        periodUnit: FhirPeriodUnit.Day
+        periodUnit: types_1.FhirPeriodUnit.Day
     },
     tid: {
         code: "TID",
         frequency: 3,
         period: 1,
-        periodUnit: FhirPeriodUnit.Day
+        periodUnit: types_1.FhirPeriodUnit.Day
     },
     qid: {
         code: "QID",
         frequency: 4,
         period: 1,
-        periodUnit: FhirPeriodUnit.Day
+        periodUnit: types_1.FhirPeriodUnit.Day
     },
-    q1h: { code: "Q1H", period: 1, periodUnit: FhirPeriodUnit.Hour },
-    q2h: { code: "Q2H", period: 2, periodUnit: FhirPeriodUnit.Hour },
-    q3h: { code: "Q3H", period: 3, periodUnit: FhirPeriodUnit.Hour },
-    q4h: { code: "Q4H", period: 4, periodUnit: FhirPeriodUnit.Hour },
-    q6h: { code: "Q6H", period: 6, periodUnit: FhirPeriodUnit.Hour },
-    q8h: { code: "Q8H", period: 8, periodUnit: FhirPeriodUnit.Hour },
-    q12h: { code: "Q12H", period: 12, periodUnit: FhirPeriodUnit.Hour },
-    q24h: { code: "Q24H", period: 24, periodUnit: FhirPeriodUnit.Hour },
+    q1h: { code: "Q1H", period: 1, periodUnit: types_1.FhirPeriodUnit.Hour },
+    q2h: { code: "Q2H", period: 2, periodUnit: types_1.FhirPeriodUnit.Hour },
+    q3h: { code: "Q3H", period: 3, periodUnit: types_1.FhirPeriodUnit.Hour },
+    q4h: { code: "Q4H", period: 4, periodUnit: types_1.FhirPeriodUnit.Hour },
+    q6h: { code: "Q6H", period: 6, periodUnit: types_1.FhirPeriodUnit.Hour },
+    q8h: { code: "Q8H", period: 8, periodUnit: types_1.FhirPeriodUnit.Hour },
+    q12h: { code: "Q12H", period: 12, periodUnit: types_1.FhirPeriodUnit.Hour },
+    q24h: { code: "Q24H", period: 24, periodUnit: types_1.FhirPeriodUnit.Hour },
     q1d: {
         code: "QD",
         frequency: 1,
         period: 1,
-        periodUnit: FhirPeriodUnit.Day
+        periodUnit: types_1.FhirPeriodUnit.Day
     },
-    q2d: { code: "Q2D", period: 2, periodUnit: FhirPeriodUnit.Day },
-    q3d: { code: "Q3D", period: 3, periodUnit: FhirPeriodUnit.Day },
-    q1wk: { code: "WK", period: 1, periodUnit: FhirPeriodUnit.Week },
-    q1w: { code: "WK", period: 1, periodUnit: FhirPeriodUnit.Week },
-    q2wk: { code: "Q2WK", period: 2, periodUnit: FhirPeriodUnit.Week },
-    q1mo: { code: "MO", period: 1, periodUnit: FhirPeriodUnit.Month },
-    q2mo: { code: "Q2MO", period: 2, periodUnit: FhirPeriodUnit.Month },
-    wk: { code: "WK", period: 1, periodUnit: FhirPeriodUnit.Week },
-    weekly: { code: "WK", period: 1, periodUnit: FhirPeriodUnit.Week },
-    mo: { code: "MO", period: 1, periodUnit: FhirPeriodUnit.Month },
-    monthly: { code: "MO", period: 1, periodUnit: FhirPeriodUnit.Month },
-    am: { code: "AM", when: [EventTiming.Morning] },
-    pm: { code: "PM", when: [EventTiming.Evening] }
-};
-export const EVENT_TIMING_TOKENS = {
-    ac: EventTiming["Before Meal"],
-    acm: EventTiming["Before Breakfast"],
-    acl: EventTiming["Before Lunch"],
-    acd: EventTiming["Before Lunch"],
-    acv: EventTiming["Before Dinner"],
-    pc: EventTiming["After Meal"],
-    pcm: EventTiming["After Breakfast"],
-    pcl: EventTiming["After Lunch"],
-    pcd: EventTiming["After Lunch"],
-    pcv: EventTiming["After Dinner"],
-    wm: EventTiming.Meal,
-    "with meals": EventTiming.Meal,
-    "@m": EventTiming.Meal,
-    "@meal": EventTiming.Meal,
-    "@meals": EventTiming.Meal,
-    cm: EventTiming.Breakfast,
-    cd: EventTiming.Lunch,
-    cv: EventTiming.Dinner,
-    am: EventTiming.Morning,
-    morning: EventTiming.Morning,
-    morn: EventTiming.Morning,
-    noon: EventTiming.Noon,
-    pm: EventTiming.Evening,
-    evening: EventTiming.Evening,
-    night: EventTiming.Night,
-    hs: EventTiming["Before Sleep"],
-    bedtime: EventTiming["Before Sleep"],
-    wake: EventTiming.Wake,
-    waking: EventTiming.Wake,
-    stat: EventTiming.Immediate
+    q2d: { code: "Q2D", period: 2, periodUnit: types_1.FhirPeriodUnit.Day },
+    q3d: { code: "Q3D", period: 3, periodUnit: types_1.FhirPeriodUnit.Day },
+    q1wk: { code: "WK", period: 1, periodUnit: types_1.FhirPeriodUnit.Week },
+    q1w: { code: "WK", period: 1, periodUnit: types_1.FhirPeriodUnit.Week },
+    q2wk: { code: "Q2WK", period: 2, periodUnit: types_1.FhirPeriodUnit.Week },
+    q1mo: { code: "MO", period: 1, periodUnit: types_1.FhirPeriodUnit.Month },
+    q2mo: { code: "Q2MO", period: 2, periodUnit: types_1.FhirPeriodUnit.Month },
+    wk: { code: "WK", period: 1, periodUnit: types_1.FhirPeriodUnit.Week },
+    weekly: { code: "WK", period: 1, periodUnit: types_1.FhirPeriodUnit.Week },
+    mo: { code: "MO", period: 1, periodUnit: types_1.FhirPeriodUnit.Month },
+    monthly: { code: "MO", period: 1, periodUnit: types_1.FhirPeriodUnit.Month },
+    am: { code: "AM", when: [types_1.EventTiming.Morning] },
+    pm: { code: "PM", when: [types_1.EventTiming.Evening] }
 };
-export const MEAL_KEYWORDS = {
-    breakfast: { pc: EventTiming["After Breakfast"], ac: EventTiming["Before Breakfast"] },
-    lunch: { pc: EventTiming["After Lunch"], ac: EventTiming["Before Lunch"] },
-    dinner: { pc: EventTiming["After Dinner"], ac: EventTiming["Before Dinner"] },
-    supper: { pc: EventTiming["After Dinner"], ac: EventTiming["Before Dinner"] }
+exports.EVENT_TIMING_TOKENS = {
+    ac: types_1.EventTiming["Before Meal"],
+    acm: types_1.EventTiming["Before Breakfast"],
+    acl: types_1.EventTiming["Before Lunch"],
+    acd: types_1.EventTiming["Before Lunch"],
+    acv: types_1.EventTiming["Before Dinner"],
+    pc: types_1.EventTiming["After Meal"],
+    pcm: types_1.EventTiming["After Breakfast"],
+    pcl: types_1.EventTiming["After Lunch"],
+    pcd: types_1.EventTiming["After Lunch"],
+    pcv: types_1.EventTiming["After Dinner"],
+    wm: types_1.EventTiming.Meal,
+    "with meals": types_1.EventTiming.Meal,
+    "@m": types_1.EventTiming.Meal,
+    "@meal": types_1.EventTiming.Meal,
+    "@meals": types_1.EventTiming.Meal,
+    cm: types_1.EventTiming.Breakfast,
+    breakfast: types_1.EventTiming.Breakfast,
+    bfast: types_1.EventTiming.Breakfast,
+    brkfst: types_1.EventTiming.Breakfast,
+    brk: types_1.EventTiming.Breakfast,
+    cd: types_1.EventTiming.Lunch,
+    lunch: types_1.EventTiming.Lunch,
+    lunchtime: types_1.EventTiming.Lunch,
+    cv: types_1.EventTiming.Dinner,
+    dinner: types_1.EventTiming.Dinner,
+    dinnertime: types_1.EventTiming.Dinner,
+    supper: types_1.EventTiming.Dinner,
+    suppertime: types_1.EventTiming.Dinner,
+    am: types_1.EventTiming.Morning,
+    morning: types_1.EventTiming.Morning,
+    morn: types_1.EventTiming.Morning,
+    noon: types_1.EventTiming.Noon,
+    midday: types_1.EventTiming.Noon,
+    "mid-day": types_1.EventTiming.Noon,
+    afternoon: types_1.EventTiming.Afternoon,
+    aft: types_1.EventTiming.Afternoon,
+    pm: types_1.EventTiming.Evening,
+    evening: types_1.EventTiming.Evening,
+    night: types_1.EventTiming.Night,
+    hs: types_1.EventTiming["Before Sleep"],
+    bedtime: types_1.EventTiming["Before Sleep"],
+    wake: types_1.EventTiming.Wake,
+    waking: types_1.EventTiming.Wake,
+    stat: types_1.EventTiming.Immediate
 };
-export const DISCOURAGED_TOKENS = {
+const MEAL_KEYWORD_ENTRIES = [];
+function registerMealKeywords(keys, meal) {
+    for (const key of keys) {
+        MEAL_KEYWORD_ENTRIES.push([key, meal]);
+    }
+}
+registerMealKeywords(["breakfast", "bfast", "brkfst", "brk"], {
+    pc: types_1.EventTiming["After Breakfast"],
+    ac: types_1.EventTiming["Before Breakfast"]
+});
+registerMealKeywords(["lunch", "lunchtime"], {
+    pc: types_1.EventTiming["After Lunch"],
+    ac: types_1.EventTiming["Before Lunch"]
+});
+registerMealKeywords(["dinner", "dinnertime", "supper", "suppertime"], {
+    pc: types_1.EventTiming["After Dinner"],
+    ac: types_1.EventTiming["Before Dinner"]
+});
+exports.MEAL_KEYWORDS = (0, object_1.objectFromEntries)(MEAL_KEYWORD_ENTRIES);
+exports.DISCOURAGED_TOKENS = {
     qd: "QD",
     qod: "QOD",
+    od: "OD",
     bld: "BLD",
     "b-l-d": "BLD",
     ad: "AD"
 };
-export const DAY_OF_WEEK_TOKENS = {
-    monday: FhirDayOfWeek.Monday,
-    mon: FhirDayOfWeek.Monday,
-    tuesday: FhirDayOfWeek.Tuesday,
-    tue: FhirDayOfWeek.Tuesday,
-    wednesday: FhirDayOfWeek.Wednesday,
-    wed: FhirDayOfWeek.Wednesday,
-    thursday: FhirDayOfWeek.Thursday,
-    thu: FhirDayOfWeek.Thursday,
-    friday: FhirDayOfWeek.Friday,
-    fri: FhirDayOfWeek.Friday,
-    saturday: FhirDayOfWeek.Saturday,
-    sat: FhirDayOfWeek.Saturday,
-    sunday: FhirDayOfWeek.Sunday,
-    sun: FhirDayOfWeek.Sunday
+exports.DAY_OF_WEEK_TOKENS = {
+    monday: types_1.FhirDayOfWeek.Monday,
+    mon: types_1.FhirDayOfWeek.Monday,
+    tuesday: types_1.FhirDayOfWeek.Tuesday,
+    tue: types_1.FhirDayOfWeek.Tuesday,
+    wednesday: types_1.FhirDayOfWeek.Wednesday,
+    wed: types_1.FhirDayOfWeek.Wednesday,
+    thursday: types_1.FhirDayOfWeek.Thursday,
+    thu: types_1.FhirDayOfWeek.Thursday,
+    friday: types_1.FhirDayOfWeek.Friday,
+    fri: types_1.FhirDayOfWeek.Friday,
+    saturday: types_1.FhirDayOfWeek.Saturday,
+    sat: types_1.FhirDayOfWeek.Saturday,
+    sunday: types_1.FhirDayOfWeek.Sunday,
+    sun: types_1.FhirDayOfWeek.Sunday
 };
-export const WORD_FREQUENCIES = {
-    daily: { frequency: 1, periodUnit: FhirPeriodUnit.Day },
-    "once daily": { frequency: 1, periodUnit: FhirPeriodUnit.Day },
-    once: { frequency: 1, periodUnit: FhirPeriodUnit.Day },
-    twice: { frequency: 2, periodUnit: FhirPeriodUnit.Day },
-    "twice daily": { frequency: 2, periodUnit: FhirPeriodUnit.Day },
-    "three times": { frequency: 3, periodUnit: FhirPeriodUnit.Day },
-    "three times daily": { frequency: 3, periodUnit: FhirPeriodUnit.Day }
+exports.WORD_FREQUENCIES = {
+    daily: { frequency: 1, periodUnit: types_1.FhirPeriodUnit.Day },
+    "once daily": { frequency: 1, periodUnit: types_1.FhirPeriodUnit.Day },
+    once: { frequency: 1, periodUnit: types_1.FhirPeriodUnit.Day },
+    twice: { frequency: 2, periodUnit: types_1.FhirPeriodUnit.Day },
+    "twice daily": { frequency: 2, periodUnit: types_1.FhirPeriodUnit.Day },
+    "three times": { frequency: 3, periodUnit: types_1.FhirPeriodUnit.Day },
+    "three times daily": { frequency: 3, periodUnit: types_1.FhirPeriodUnit.Day }
 };
-export const KNOWN_DOSAGE_FORMS_TO_DOSE = {
+exports.KNOWN_DOSAGE_FORMS_TO_DOSE = {
     "nasal spray, suspension": "nasal spray",
     "implantation chain": "implantation chain",
     capsule: "capsule",
@@ -353,6 +489,9 @@ export const KNOWN_DOSAGE_FORMS_TO_DOSE = {
     collodion: "collodion",
     "powder for rectal solution": "powder for rectal solution",
     "eye drops, solution": "eye drops, solution",
+    // additional helpers
+    "eye drops": "eye drops, solution",
+    "eye drop": "eye drops, solution",
     "oromucosal paste": "oromucosal paste",
     "dental paste": "dental paste",
     "solution for peritoneal dialysis": "solution for peritoneal dialysis",
@@ -481,188 +620,190 @@ export const KNOWN_DOSAGE_FORMS_TO_DOSE = {
  * Map of normalized dosage-form labels to their associated SNOMED route code.
  * The keys intentionally mirror KNOWN_DOSAGE_FORMS_TO_DOSE to keep lookups simple.
  */
-export const KNOWN_TMT_DOSAGE_FORM_TO_SNOMED_ROUTE = {
-    "nasal spray, suspension": SNOMEDCTRouteCodes["Nasal route"],
-    "implantation chain": SNOMEDCTRouteCodes["Intralesional use"],
-    capsule: SNOMEDCTRouteCodes["Oral route"],
-    "capsule, soft": SNOMEDCTRouteCodes["Oral route"],
-    "oral solution": SNOMEDCTRouteCodes["Oral route"],
-    "oral suspension": SNOMEDCTRouteCodes["Oral route"],
-    "inhalation powder": SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "nasal spray, solution": SNOMEDCTRouteCodes["Nasal route"],
-    "pressurised inhalation, suspension": SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "pressurised inhalation, solution": SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "rectal foam": SNOMEDCTRouteCodes["Per rectum"],
-    "sublingual spray, solution": SNOMEDCTRouteCodes["Sublingual route"],
-    "inhalation vapour, solution": SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "inhalation powder, pre-dispensed": SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "solution for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "inhalation solution": SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    cream: SNOMEDCTRouteCodes["Topical route"],
-    "cutaneous powder": SNOMEDCTRouteCodes["Topical route"],
-    "powder for solution for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    gel: SNOMEDCTRouteCodes["Topical route"],
-    "granules for oral solution": SNOMEDCTRouteCodes["Oral route"],
-    "powder for oral solution": SNOMEDCTRouteCodes["Oral route"],
-    "oral paste": SNOMEDCTRouteCodes["Oromucosal use"],
-    "cutaneous stick": SNOMEDCTRouteCodes["Transdermal route"],
-    "prolonged-release granules": SNOMEDCTRouteCodes["Oral route"],
-    "oromucosal gel": SNOMEDCTRouteCodes["Oromucosal use"],
-    "oral powder": SNOMEDCTRouteCodes["Oral route"],
-    ointment: SNOMEDCTRouteCodes["Topical route"],
-    "cutaneous paste": SNOMEDCTRouteCodes["Topical route"],
-    "powder for oral suspension": SNOMEDCTRouteCodes["Oral route"],
-    "vaginal gel": SNOMEDCTRouteCodes["Per vagina"],
-    "nasal drops, powder for solution": SNOMEDCTRouteCodes["Nasal route"],
-    "oral gel": SNOMEDCTRouteCodes["Oromucosal use"],
-    "eye gel": SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "impregnated dressing": SNOMEDCTRouteCodes["Topical route"],
-    "vaginal cream": SNOMEDCTRouteCodes["Per vagina"],
-    "ear powder": SNOMEDCTRouteCodes["Otic route"],
-    "cutaneous emulsion": SNOMEDCTRouteCodes["Topical route"],
-    "cutaneous liquid": SNOMEDCTRouteCodes["Topical route"],
-    "cutaneous solution": SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
-    "effervescent powder": SNOMEDCTRouteCodes["Oral route"],
-    "bath additive": SNOMEDCTRouteCodes["Topical route"],
-    "nasal spray, powder for solution": SNOMEDCTRouteCodes["Nasal route"],
-    "powder for cutaneous solution": SNOMEDCTRouteCodes["Topical route"],
-    "dental gel": SNOMEDCTRouteCodes["Gingival use"],
-    "nasal gel": SNOMEDCTRouteCodes["Nasal route"],
-    "powder for oral/rectal suspension": SNOMEDCTRouteCodes["Oral route"],
-    "gingival gel": SNOMEDCTRouteCodes["Gingival use"],
-    "powder for solution for infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "gastro-resistant granules": SNOMEDCTRouteCodes["Oral route"],
-    "eye ointment": SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "oromucosal spray, solution": SNOMEDCTRouteCodes["Oropharyngeal route (qualifier value)"],
-    granules: SNOMEDCTRouteCodes["Oral route"],
-    collodion: SNOMEDCTRouteCodes["Oral route"],
-    "powder for rectal solution": SNOMEDCTRouteCodes["Per rectum"],
-    "eye drops, solution": SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "oromucosal paste": SNOMEDCTRouteCodes["Oromucosal use"],
-    "dental paste": SNOMEDCTRouteCodes["Dental use"],
-    "solution for peritoneal dialysis": SNOMEDCTRouteCodes["Intradialytic route"],
-    paste: SNOMEDCTRouteCodes["Topical route"],
-    "effervescent granules": SNOMEDCTRouteCodes["Oral route"],
-    shampoo: SNOMEDCTRouteCodes["Topical route"],
-    "solution for infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    syrup: SNOMEDCTRouteCodes["Oral route"],
-    "oral liquid": SNOMEDCTRouteCodes["Oral route"],
-    "oral drops, solution": SNOMEDCTRouteCodes["Oral route"],
-    "emulsion for infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "irrigation solution": SNOMEDCTRouteCodes["Topical route"],
-    "solution for injection/infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "solution for haemodialysis/haemofiltration": SNOMEDCTRouteCodes["Intradialytic route"],
-    "solution for organ preservation": SNOMEDCTRouteCodes["Extracorporeal route (qualifier value)"],
-    "gargle/mouthwash": SNOMEDCTRouteCodes["Oromucosal use"],
-    "concentrate for solution for injection/infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "concentrate for cutaneous solution": SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
-    "cutaneous spray, solution": SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
-    "concentrate for dip solution": SNOMEDCTRouteCodes["Topical route"],
-    "oral emulsion": SNOMEDCTRouteCodes["Oral route"],
-    "concentrate for oral solution": SNOMEDCTRouteCodes["Oral route"],
-    "concentrate for haemodialysis solution": SNOMEDCTRouteCodes["Intradialytic route"],
-    "suspension for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and solvent for solution for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and suspension for suspension for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "powder for suspension for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "transdermal patch": SNOMEDCTRouteCodes["Transdermal route"],
-    "powder and solvent for suspension for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "endotracheopulmonary instillation, powder for solution": SNOMEDCTRouteCodes["Endotracheopulmonary use"],
-    "intrauterine delivery system": SNOMEDCTRouteCodes["Intrauterine route"],
-    implant: SNOMEDCTRouteCodes["Intradermal use"],
-    "powder for solution for injection/infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "concentrate for solution for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "eye drops, emulsion": SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "concentrate for dispersion for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "concentrate for solution for infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "concentrate and solvent for solution for infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "concentrate and solvent for suspension for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "gel for injection": SNOMEDCTRouteCodes["Intramuscular route"],
-    "prolonged-release suspension for injection": SNOMEDCTRouteCodes["Intramuscular route"],
-    "rectal solution": SNOMEDCTRouteCodes["Per rectum"],
-    "emulsion for injection": SNOMEDCTRouteCodes["Intramuscular route"],
-    "oromucosal solution": SNOMEDCTRouteCodes["Oromucosal use"],
-    "powder and solvent for solution for infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "emulsion for injection/infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "solution for cardioplegia": SNOMEDCTRouteCodes["Intravenous route"],
-    "endotracheopulmonary instillation, suspension": SNOMEDCTRouteCodes["Endotracheopulmonary use"],
-    "ear drops, solution": SNOMEDCTRouteCodes["Otic route"],
-    "eye drops, suspension": SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "nasal drops, solution": SNOMEDCTRouteCodes["Nasal route"],
-    "suspension and solution for spray": SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "solution for sealant": SNOMEDCTRouteCodes["Topical route"],
-    "inhalation vapour, liquid": SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "ear drops, suspension": SNOMEDCTRouteCodes["Otic route"],
-    "dental suspension": SNOMEDCTRouteCodes["Dental use"],
-    "nebuliser solution": SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "concentrate for gargle": SNOMEDCTRouteCodes["Oropharyngeal route (qualifier value)"],
-    "ear/eye drops, solution": SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "ear wash, solution": SNOMEDCTRouteCodes["Otic route"],
-    "oromucosal drops": SNOMEDCTRouteCodes["Oromucosal use"],
-    "powder for syrup": SNOMEDCTRouteCodes["Oral route"],
-    "cutaneous suspension": SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
-    "eye lotion": SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "rectal suspension": SNOMEDCTRouteCodes["Per rectum"],
-    "intestinal gel": SNOMEDCTRouteCodes["Intestinal route (qualifier value)"],
-    "dental solution": SNOMEDCTRouteCodes["Dental use"],
-    "gingival solution": SNOMEDCTRouteCodes["Gingival use"],
-    "oral drops, suspension": SNOMEDCTRouteCodes["Oral route"],
-    "eye drops, tablet and solvent for solution": SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
-    "nebuliser suspension": SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    "dispersion for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and solvent for oral solution": SNOMEDCTRouteCodes["Oral route"],
-    solution: SNOMEDCTRouteCodes["Oral route"],
-    "powder and solvent for oral suspension": SNOMEDCTRouteCodes["Oral route"],
-    "suspension and effervescent granules for oral suspension": SNOMEDCTRouteCodes["Oral route"],
-    "oral drops, emulsion": SNOMEDCTRouteCodes["Oral route"],
-    "oral drops, liquid": SNOMEDCTRouteCodes["Oral route"],
-    "oral/rectal suspension": SNOMEDCTRouteCodes["Oral route"],
-    "intravesical solution": SNOMEDCTRouteCodes["Intralesional use"],
-    "granules for oral suspension": SNOMEDCTRouteCodes["Oral route"],
-    "granules for syrup": SNOMEDCTRouteCodes["Oral route"],
-    tablet: SNOMEDCTRouteCodes["Oral route"],
-    "film-coated tablet": SNOMEDCTRouteCodes["Oral route"],
-    "coated tablet": SNOMEDCTRouteCodes["Oral route"],
-    "chewable tablet": SNOMEDCTRouteCodes["Oral route"],
-    "capsule, hard": SNOMEDCTRouteCodes["Oral route"],
-    "gastro-resistant tablet": SNOMEDCTRouteCodes["Oral route"],
-    "gastro-resistant granules for oral suspension": SNOMEDCTRouteCodes["Oral route"],
-    "orodispersible tablet": SNOMEDCTRouteCodes["Oral route"],
-    "gastro-resistant capsule, hard": SNOMEDCTRouteCodes["Oral route"],
-    "prolonged-release capsule, hard": SNOMEDCTRouteCodes["Oral route"],
-    "prolonged-release tablet": SNOMEDCTRouteCodes["Oral route"],
-    suppository: SNOMEDCTRouteCodes["Per rectum"],
-    lozenge: SNOMEDCTRouteCodes["Oropharyngeal route (qualifier value)"],
-    "modified-release tablet": SNOMEDCTRouteCodes["Oral route"],
-    "dispersible tablet": SNOMEDCTRouteCodes["Oral route"],
-    injection: SNOMEDCTRouteCodes["Intravenous route"],
-    "powder for concentrate for solution for infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and solvent for solution for injection/infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and solvent for prolonged-release suspension for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "powder and solvent for concentrate for solution for infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "sublingual tablet": SNOMEDCTRouteCodes["Sublingual route"],
-    "effervescent tablet": SNOMEDCTRouteCodes["Oral route"],
-    "vaginal tablet": SNOMEDCTRouteCodes["Per vagina"],
-    "inhalation powder, hard capsule": SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
-    pessary: SNOMEDCTRouteCodes["Per vagina"],
-    "vaginal capsule, hard": SNOMEDCTRouteCodes["Per vagina"],
-    pastille: SNOMEDCTRouteCodes["Oral route"],
-    "medicated chewing-gum": SNOMEDCTRouteCodes["Oral route"],
-    "vaginal delivery system": SNOMEDCTRouteCodes["Per vagina"],
-    "medicated plaster": SNOMEDCTRouteCodes["Transdermal route"],
-    "intravitreal implant in applicator": SNOMEDCTRouteCodes["Intravitreal route (qualifier value)"],
-    "vaginal capsule, soft": SNOMEDCTRouteCodes["Per vagina"],
-    "lyophilisate and solvent for solution for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "powder for concentrate for dispersion for infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "powder for suspension for infusion": SNOMEDCTRouteCodes["Intravenous route"],
-    "cutaneous patch": SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
-    "modified-release capsule, hard": SNOMEDCTRouteCodes["Oral route"],
-    "oral lyophilisate": SNOMEDCTRouteCodes["Oral route"],
-    "powders for solution for injection": SNOMEDCTRouteCodes["Intravenous route"],
-    "capsule, hard-capsule, soft-tablet": SNOMEDCTRouteCodes["Oral route"],
-    "capsule, hard-tablet": SNOMEDCTRouteCodes["Oral route"]
+exports.KNOWN_TMT_DOSAGE_FORM_TO_SNOMED_ROUTE = {
+    "nasal spray, suspension": types_1.SNOMEDCTRouteCodes["Nasal route"],
+    "implantation chain": types_1.SNOMEDCTRouteCodes["Intralesional use"],
+    capsule: types_1.SNOMEDCTRouteCodes["Oral route"],
+    "capsule, soft": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "oral solution": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "inhalation powder": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
+    "nasal spray, solution": types_1.SNOMEDCTRouteCodes["Nasal route"],
+    "pressurised inhalation, suspension": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
+    "pressurised inhalation, solution": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
+    "rectal foam": types_1.SNOMEDCTRouteCodes["Per rectum"],
+    "sublingual spray, solution": types_1.SNOMEDCTRouteCodes["Sublingual route"],
+    "inhalation vapour, solution": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
+    "inhalation powder, pre-dispensed": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
+    "solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "inhalation solution": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
+    cream: types_1.SNOMEDCTRouteCodes["Topical route"],
+    "cutaneous powder": types_1.SNOMEDCTRouteCodes["Topical route"],
+    "powder for solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    gel: types_1.SNOMEDCTRouteCodes["Topical route"],
+    "granules for oral solution": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "powder for oral solution": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "oral paste": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
+    "cutaneous stick": types_1.SNOMEDCTRouteCodes["Transdermal route"],
+    "prolonged-release granules": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "oromucosal gel": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
+    "oral powder": types_1.SNOMEDCTRouteCodes["Oral route"],
+    ointment: types_1.SNOMEDCTRouteCodes["Topical route"],
+    "cutaneous paste": types_1.SNOMEDCTRouteCodes["Topical route"],
+    "powder for oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "vaginal gel": types_1.SNOMEDCTRouteCodes["Per vagina"],
+    "nasal drops, powder for solution": types_1.SNOMEDCTRouteCodes["Nasal route"],
+    "oral gel": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
+    "eye gel": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
+    "impregnated dressing": types_1.SNOMEDCTRouteCodes["Topical route"],
+    "vaginal cream": types_1.SNOMEDCTRouteCodes["Per vagina"],
+    "ear powder": types_1.SNOMEDCTRouteCodes["Otic route"],
+    "cutaneous emulsion": types_1.SNOMEDCTRouteCodes["Topical route"],
+    "cutaneous liquid": types_1.SNOMEDCTRouteCodes["Topical route"],
+    "cutaneous solution": types_1.SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
+    "effervescent powder": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "bath additive": types_1.SNOMEDCTRouteCodes["Topical route"],
+    "nasal spray, powder for solution": types_1.SNOMEDCTRouteCodes["Nasal route"],
+    "powder for cutaneous solution": types_1.SNOMEDCTRouteCodes["Topical route"],
+    "dental gel": types_1.SNOMEDCTRouteCodes["Gingival use"],
+    "nasal gel": types_1.SNOMEDCTRouteCodes["Nasal route"],
+    "powder for oral/rectal suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "gingival gel": types_1.SNOMEDCTRouteCodes["Gingival use"],
+    "powder for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "gastro-resistant granules": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "eye ointment": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
+    "oromucosal spray, solution": types_1.SNOMEDCTRouteCodes["Oropharyngeal route (qualifier value)"],
+    granules: types_1.SNOMEDCTRouteCodes["Oral route"],
+    collodion: types_1.SNOMEDCTRouteCodes["Oral route"],
+    "powder for rectal solution": types_1.SNOMEDCTRouteCodes["Per rectum"],
+    "eye drops, solution": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
+    "eye drops": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
+    "eye drop": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
+    "oromucosal paste": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
+    "dental paste": types_1.SNOMEDCTRouteCodes["Dental use"],
+    "solution for peritoneal dialysis": types_1.SNOMEDCTRouteCodes["Intradialytic route"],
+    paste: types_1.SNOMEDCTRouteCodes["Topical route"],
+    "effervescent granules": types_1.SNOMEDCTRouteCodes["Oral route"],
+    shampoo: types_1.SNOMEDCTRouteCodes["Topical route"],
+    "solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    syrup: types_1.SNOMEDCTRouteCodes["Oral route"],
+    "oral liquid": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "oral drops, solution": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "emulsion for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "irrigation solution": types_1.SNOMEDCTRouteCodes["Topical route"],
+    "solution for injection/infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "solution for haemodialysis/haemofiltration": types_1.SNOMEDCTRouteCodes["Intradialytic route"],
+    "solution for organ preservation": types_1.SNOMEDCTRouteCodes["Extracorporeal route (qualifier value)"],
+    "gargle/mouthwash": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
+    "concentrate for solution for injection/infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "concentrate for cutaneous solution": types_1.SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
+    "cutaneous spray, solution": types_1.SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
+    "concentrate for dip solution": types_1.SNOMEDCTRouteCodes["Topical route"],
+    "oral emulsion": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "concentrate for oral solution": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "concentrate for haemodialysis solution": types_1.SNOMEDCTRouteCodes["Intradialytic route"],
+    "suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "powder and solvent for solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "powder and suspension for suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "powder for suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "transdermal patch": types_1.SNOMEDCTRouteCodes["Transdermal route"],
+    "powder and solvent for suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "endotracheopulmonary instillation, powder for solution": types_1.SNOMEDCTRouteCodes["Endotracheopulmonary use"],
+    "intrauterine delivery system": types_1.SNOMEDCTRouteCodes["Intrauterine route"],
+    implant: types_1.SNOMEDCTRouteCodes["Intradermal use"],
+    "powder for solution for injection/infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "concentrate for solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "eye drops, emulsion": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
+    "concentrate for dispersion for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "concentrate for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "concentrate and solvent for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "concentrate and solvent for suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "gel for injection": types_1.SNOMEDCTRouteCodes["Intramuscular route"],
+    "prolonged-release suspension for injection": types_1.SNOMEDCTRouteCodes["Intramuscular route"],
+    "rectal solution": types_1.SNOMEDCTRouteCodes["Per rectum"],
+    "emulsion for injection": types_1.SNOMEDCTRouteCodes["Intramuscular route"],
+    "oromucosal solution": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
+    "powder and solvent for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "emulsion for injection/infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "solution for cardioplegia": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "endotracheopulmonary instillation, suspension": types_1.SNOMEDCTRouteCodes["Endotracheopulmonary use"],
+    "ear drops, solution": types_1.SNOMEDCTRouteCodes["Otic route"],
+    "eye drops, suspension": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
+    "nasal drops, solution": types_1.SNOMEDCTRouteCodes["Nasal route"],
+    "suspension and solution for spray": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
+    "solution for sealant": types_1.SNOMEDCTRouteCodes["Topical route"],
+    "inhalation vapour, liquid": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
+    "ear drops, suspension": types_1.SNOMEDCTRouteCodes["Otic route"],
+    "dental suspension": types_1.SNOMEDCTRouteCodes["Dental use"],
+    "nebuliser solution": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
+    "concentrate for gargle": types_1.SNOMEDCTRouteCodes["Oropharyngeal route (qualifier value)"],
+    "ear/eye drops, solution": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
+    "ear wash, solution": types_1.SNOMEDCTRouteCodes["Otic route"],
+    "oromucosal drops": types_1.SNOMEDCTRouteCodes["Oromucosal use"],
+    "powder for syrup": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "cutaneous suspension": types_1.SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
+    "eye lotion": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
+    "rectal suspension": types_1.SNOMEDCTRouteCodes["Per rectum"],
+    "intestinal gel": types_1.SNOMEDCTRouteCodes["Intestinal route (qualifier value)"],
+    "dental solution": types_1.SNOMEDCTRouteCodes["Dental use"],
+    "gingival solution": types_1.SNOMEDCTRouteCodes["Gingival use"],
+    "oral drops, suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "eye drops, tablet and solvent for solution": types_1.SNOMEDCTRouteCodes["Ocular route (qualifier value)"],
+    "nebuliser suspension": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
+    "dispersion for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "powder and solvent for oral solution": types_1.SNOMEDCTRouteCodes["Oral route"],
+    solution: types_1.SNOMEDCTRouteCodes["Oral route"],
+    "powder and solvent for oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "suspension and effervescent granules for oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "oral drops, emulsion": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "oral drops, liquid": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "oral/rectal suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "intravesical solution": types_1.SNOMEDCTRouteCodes["Intralesional use"],
+    "granules for oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "granules for syrup": types_1.SNOMEDCTRouteCodes["Oral route"],
+    tablet: types_1.SNOMEDCTRouteCodes["Oral route"],
+    "film-coated tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "coated tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "chewable tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "capsule, hard": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "gastro-resistant tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "gastro-resistant granules for oral suspension": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "orodispersible tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "gastro-resistant capsule, hard": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "prolonged-release capsule, hard": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "prolonged-release tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
+    suppository: types_1.SNOMEDCTRouteCodes["Per rectum"],
+    lozenge: types_1.SNOMEDCTRouteCodes["Oropharyngeal route (qualifier value)"],
+    "modified-release tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "dispersible tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
+    injection: types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "powder for concentrate for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "powder and solvent for solution for injection/infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "powder and solvent for prolonged-release suspension for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "powder and solvent for concentrate for solution for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "sublingual tablet": types_1.SNOMEDCTRouteCodes["Sublingual route"],
+    "effervescent tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "vaginal tablet": types_1.SNOMEDCTRouteCodes["Per vagina"],
+    "inhalation powder, hard capsule": types_1.SNOMEDCTRouteCodes["Respiratory tract route (qualifier value)"],
+    pessary: types_1.SNOMEDCTRouteCodes["Per vagina"],
+    "vaginal capsule, hard": types_1.SNOMEDCTRouteCodes["Per vagina"],
+    pastille: types_1.SNOMEDCTRouteCodes["Oral route"],
+    "medicated chewing-gum": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "vaginal delivery system": types_1.SNOMEDCTRouteCodes["Per vagina"],
+    "medicated plaster": types_1.SNOMEDCTRouteCodes["Transdermal route"],
+    "intravitreal implant in applicator": types_1.SNOMEDCTRouteCodes["Intravitreal route (qualifier value)"],
+    "vaginal capsule, soft": types_1.SNOMEDCTRouteCodes["Per vagina"],
+    "lyophilisate and solvent for solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "powder for concentrate for dispersion for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "powder for suspension for infusion": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "cutaneous patch": types_1.SNOMEDCTRouteCodes["Cutaneous route (qualifier value)"],
+    "modified-release capsule, hard": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "oral lyophilisate": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "powders for solution for injection": types_1.SNOMEDCTRouteCodes["Intravenous route"],
+    "capsule, hard-capsule, soft-tablet": types_1.SNOMEDCTRouteCodes["Oral route"],
+    "capsule, hard-tablet": types_1.SNOMEDCTRouteCodes["Oral route"]
 };
-export const DEFAULT_UNIT_BY_NORMALIZED_FORM = {
+exports.DEFAULT_UNIT_BY_NORMALIZED_FORM = {
     tab: "tab",
     tabs: "tab",
     tablet: "tab",
@@ -747,3 +888,55 @@ export const DEFAULT_UNIT_BY_NORMALIZED_FORM = {
     "intravitreal implant in applicator": "implant",
     "medicated chewing-gum": "piece"
 };
+const ROUTE_UNIT_FALLBACK_WHITELIST = new Set([
+    "drop",
+    "puff",
+    "spray",
+    "patch",
+    "suppository",
+    "implant",
+    "piece",
+    "stick",
+    "pessary",
+    "lozenge"
+]);
+exports.DEFAULT_UNIT_BY_ROUTE = (() => {
+    const unitCandidates = new Map();
+    for (const [form, snomed] of (0, object_1.objectEntries)(exports.KNOWN_TMT_DOSAGE_FORM_TO_SNOMED_ROUTE)) {
+        const routeCode = exports.ROUTE_BY_SNOMED[snomed];
+        if (!routeCode) {
+            continue;
+        }
+        const unit = exports.DEFAULT_UNIT_BY_NORMALIZED_FORM[form];
+        if (!unit) {
+            continue;
+        }
+        let unitsForRoute = unitCandidates.get(routeCode);
+        if (!unitsForRoute) {
+            unitsForRoute = new Set();
+            unitCandidates.set(routeCode, unitsForRoute);
+        }
+        unitsForRoute.add(unit);
+    }
+    const resolved = {};
+    for (const [route, units] of unitCandidates) {
+        if (units.size !== 1) {
+            continue;
+        }
+        const [unit] = Array.from(units);
+        if (unit && ROUTE_UNIT_FALLBACK_WHITELIST.has(unit)) {
+            resolved[route] = unit;
+        }
+    }
+    const ensure = (route, unit) => {
+        if (ROUTE_UNIT_FALLBACK_WHITELIST.has(unit)) {
+            resolved[route] = unit;
+        }
+    };
+    ensure(types_1.RouteCode["Ophthalmic route"], "drop");
+    ensure(types_1.RouteCode["Ocular route (qualifier value)"], "drop");
+    ensure(types_1.RouteCode["Otic route"], "drop");
+    ensure(types_1.RouteCode["Respiratory tract route (qualifier value)"], "puff");
+    ensure(types_1.RouteCode["Transdermal route"], "patch");
+    return resolved;
+})();