boltz-api 0.35.2 → 0.36.0

package/src/resources/protein/design.ts

@@ -543,14 +543,11 @@ export namespace DesignRetrieveResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          | DesignedProteinEntityResponse.CcdModificationResponse
-          | DesignedProteinEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<DesignedProteinEntityResponse.Modification>;
       }
 
       export namespace DesignedProteinEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -564,20 +561,6 @@ export namespace DesignRetrieveResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       /**
@@ -604,14 +587,11 @@ export namespace DesignRetrieveResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          | FixedProteinEntityResponse.CcdModificationResponse
-          | FixedProteinEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<FixedProteinEntityResponse.Modification>;
       }
 
       export namespace FixedProteinEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -625,20 +605,6 @@ export namespace DesignRetrieveResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface FixedRnaEntityResponse {
@@ -662,13 +628,11 @@ export namespace DesignRetrieveResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          FixedRnaEntityResponse.CcdModificationResponse | FixedRnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<FixedRnaEntityResponse.Modification>;
       }
 
       export namespace FixedRnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -682,20 +646,6 @@ export namespace DesignRetrieveResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface FixedDnaEntityResponse {
@@ -719,13 +669,11 @@ export namespace DesignRetrieveResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          FixedDnaEntityResponse.CcdModificationResponse | FixedDnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<FixedDnaEntityResponse.Modification>;
       }
 
       export namespace FixedDnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -739,20 +687,6 @@ export namespace DesignRetrieveResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface FixedLigandSmilesEntityResponse {
@@ -1105,13 +1039,11 @@ export namespace DesignRetrieveResponse {
          * Post-translational modifications. Optional; defaults to an empty list when
          * omitted.
          */
-        modifications?: Array<
-          ProteinEntityResponse.CcdModificationResponse | ProteinEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<ProteinEntityResponse.Modification>;
       }
 
       export namespace ProteinEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -1125,20 +1057,6 @@ export namespace DesignRetrieveResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface RnaEntityResponse {
@@ -1162,13 +1080,11 @@ export namespace DesignRetrieveResponse {
         /**
          * Chemical modifications. Optional; defaults to an empty list when omitted.
          */
-        modifications?: Array<
-          RnaEntityResponse.CcdModificationResponse | RnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<RnaEntityResponse.Modification>;
       }
 
       export namespace RnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -1182,20 +1098,6 @@ export namespace DesignRetrieveResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface DnaEntityResponse {
@@ -1219,13 +1121,11 @@ export namespace DesignRetrieveResponse {
         /**
          * Chemical modifications. Optional; defaults to an empty list when omitted.
          */
-        modifications?: Array<
-          DnaEntityResponse.CcdModificationResponse | DnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<DnaEntityResponse.Modification>;
       }
 
       export namespace DnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -1239,20 +1139,6 @@ export namespace DesignRetrieveResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface LigandCcdEntityResponse {
@@ -1774,11 +1660,11 @@ export namespace DesignListResultsResponse {
      * Post-translational modifications. Optional; defaults to an empty list when
      * omitted.
      */
-    modifications?: Array<ProteinEntity.CcdModification | ProteinEntity.SmilesModification>;
+    modifications?: Array<ProteinEntity.Modification>;
   }
 
   export namespace ProteinEntity {
-    export interface CcdModification {
+    export interface Modification {
       /**
        * 0-based index of the residue to modify
        */
@@ -1792,20 +1678,6 @@ export namespace DesignListResultsResponse {
        */
       value: string;
     }
-
-    export interface SmilesModification {
-      /**
-       * 0-based index of the residue to modify
-       */
-      residue_index: number;
-
-      type: 'smiles';
-
-      /**
-       * SMILES string for the modification
-       */
-      value: string;
-    }
   }
 
   export interface RnaEntity {
@@ -1829,11 +1701,11 @@ export namespace DesignListResultsResponse {
     /**
      * Chemical modifications. Optional; defaults to an empty list when omitted.
      */
-    modifications?: Array<RnaEntity.CcdModification | RnaEntity.SmilesModification>;
+    modifications?: Array<RnaEntity.Modification>;
   }
 
   export namespace RnaEntity {
-    export interface CcdModification {
+    export interface Modification {
       /**
        * 0-based index of the residue to modify
        */
@@ -1847,20 +1719,6 @@ export namespace DesignListResultsResponse {
        */
       value: string;
     }
-
-    export interface SmilesModification {
-      /**
-       * 0-based index of the residue to modify
-       */
-      residue_index: number;
-
-      type: 'smiles';
-
-      /**
-       * SMILES string for the modification
-       */
-      value: string;
-    }
   }
 
   export interface DnaEntity {
@@ -1884,11 +1742,11 @@ export namespace DesignListResultsResponse {
     /**
      * Chemical modifications. Optional; defaults to an empty list when omitted.
      */
-    modifications?: Array<DnaEntity.CcdModification | DnaEntity.SmilesModification>;
+    modifications?: Array<DnaEntity.Modification>;
   }
 
   export namespace DnaEntity {
-    export interface CcdModification {
+    export interface Modification {
       /**
        * 0-based index of the residue to modify
        */
@@ -1902,20 +1760,6 @@ export namespace DesignListResultsResponse {
        */
       value: string;
     }
-
-    export interface SmilesModification {
-      /**
-       * 0-based index of the residue to modify
-       */
-      residue_index: number;
-
-      type: 'smiles';
-
-      /**
-       * SMILES string for the modification
-       */
-      value: string;
-    }
   }
 
   export interface LigandCcdEntity {
@@ -2364,14 +2208,11 @@ export namespace DesignStartResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          | DesignedProteinEntityResponse.CcdModificationResponse
-          | DesignedProteinEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<DesignedProteinEntityResponse.Modification>;
       }
 
       export namespace DesignedProteinEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -2385,20 +2226,6 @@ export namespace DesignStartResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       /**
@@ -2425,14 +2252,11 @@ export namespace DesignStartResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          | FixedProteinEntityResponse.CcdModificationResponse
-          | FixedProteinEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<FixedProteinEntityResponse.Modification>;
       }
 
       export namespace FixedProteinEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -2446,20 +2270,6 @@ export namespace DesignStartResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface FixedRnaEntityResponse {
@@ -2483,13 +2293,11 @@ export namespace DesignStartResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          FixedRnaEntityResponse.CcdModificationResponse | FixedRnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<FixedRnaEntityResponse.Modification>;
       }
 
       export namespace FixedRnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -2503,20 +2311,6 @@ export namespace DesignStartResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface FixedDnaEntityResponse {
@@ -2540,13 +2334,11 @@ export namespace DesignStartResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          FixedDnaEntityResponse.CcdModificationResponse | FixedDnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<FixedDnaEntityResponse.Modification>;
       }
 
       export namespace FixedDnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -2560,20 +2352,6 @@ export namespace DesignStartResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface FixedLigandSmilesEntityResponse {
@@ -2926,13 +2704,11 @@ export namespace DesignStartResponse {
          * Post-translational modifications. Optional; defaults to an empty list when
          * omitted.
          */
-        modifications?: Array<
-          ProteinEntityResponse.CcdModificationResponse | ProteinEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<ProteinEntityResponse.Modification>;
       }
 
       export namespace ProteinEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -2946,20 +2722,6 @@ export namespace DesignStartResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface RnaEntityResponse {
@@ -2983,13 +2745,11 @@ export namespace DesignStartResponse {
         /**
          * Chemical modifications. Optional; defaults to an empty list when omitted.
          */
-        modifications?: Array<
-          RnaEntityResponse.CcdModificationResponse | RnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<RnaEntityResponse.Modification>;
       }
 
       export namespace RnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -3003,20 +2763,6 @@ export namespace DesignStartResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface DnaEntityResponse {
@@ -3040,13 +2786,11 @@ export namespace DesignStartResponse {
         /**
          * Chemical modifications. Optional; defaults to an empty list when omitted.
          */
-        modifications?: Array<
-          DnaEntityResponse.CcdModificationResponse | DnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<DnaEntityResponse.Modification>;
       }
 
       export namespace DnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -3060,20 +2804,6 @@ export namespace DesignStartResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface LigandCcdEntityResponse {
@@ -3712,14 +3442,11 @@ export namespace DesignStopResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          | DesignedProteinEntityResponse.CcdModificationResponse
-          | DesignedProteinEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<DesignedProteinEntityResponse.Modification>;
       }
 
       export namespace DesignedProteinEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -3733,20 +3460,6 @@ export namespace DesignStopResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       /**
@@ -3773,14 +3486,11 @@ export namespace DesignStopResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          | FixedProteinEntityResponse.CcdModificationResponse
-          | FixedProteinEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<FixedProteinEntityResponse.Modification>;
       }
 
       export namespace FixedProteinEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -3794,20 +3504,6 @@ export namespace DesignStopResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface FixedRnaEntityResponse {
@@ -3831,13 +3527,11 @@ export namespace DesignStopResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          FixedRnaEntityResponse.CcdModificationResponse | FixedRnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<FixedRnaEntityResponse.Modification>;
       }
 
       export namespace FixedRnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -3851,20 +3545,6 @@ export namespace DesignStopResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface FixedDnaEntityResponse {
@@ -3888,13 +3568,11 @@ export namespace DesignStopResponse {
         /**
          * Optional polymer modifications. Defaults to [] when omitted.
          */
-        modifications?: Array<
-          FixedDnaEntityResponse.CcdModificationResponse | FixedDnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<FixedDnaEntityResponse.Modification>;
       }
 
       export namespace FixedDnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -3908,20 +3586,6 @@ export namespace DesignStopResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface FixedLigandSmilesEntityResponse {
@@ -4274,13 +3938,11 @@ export namespace DesignStopResponse {
          * Post-translational modifications. Optional; defaults to an empty list when
          * omitted.
          */
-        modifications?: Array<
-          ProteinEntityResponse.CcdModificationResponse | ProteinEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<ProteinEntityResponse.Modification>;
       }
 
       export namespace ProteinEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -4294,20 +3956,6 @@ export namespace DesignStopResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface RnaEntityResponse {
@@ -4331,13 +3979,11 @@ export namespace DesignStopResponse {
         /**
          * Chemical modifications. Optional; defaults to an empty list when omitted.
          */
-        modifications?: Array<
-          RnaEntityResponse.CcdModificationResponse | RnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<RnaEntityResponse.Modification>;
       }
 
       export namespace RnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -4351,20 +3997,6 @@ export namespace DesignStopResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface DnaEntityResponse {
@@ -4388,13 +4020,11 @@ export namespace DesignStopResponse {
         /**
          * Chemical modifications. Optional; defaults to an empty list when omitted.
          */
-        modifications?: Array<
-          DnaEntityResponse.CcdModificationResponse | DnaEntityResponse.SmilesModificationResponse
-        >;
+        modifications?: Array<DnaEntityResponse.Modification>;
       }
 
       export namespace DnaEntityResponse {
-        export interface CcdModificationResponse {
+        export interface Modification {
           /**
            * 0-based index of the residue to modify
            */
@@ -4408,20 +4038,6 @@ export namespace DesignStopResponse {
            */
           value: string;
         }
-
-        export interface SmilesModificationResponse {
-          /**
-           * 0-based index of the residue to modify
-           */
-          residue_index: number;
-
-          type: 'smiles';
-
-          /**
-           * SMILES string for the modification
-           */
-          value: string;
-        }
       }
 
       export interface LigandCcdEntityResponse {
@@ -5007,11 +4623,11 @@ export namespace DesignEstimateCostParams {
       /**
        * Optional polymer modifications. Defaults to [] when omitted.
        */
-      modifications?: Array<DesignedProteinEntity.CcdModification | DesignedProteinEntity.SmilesModification>;
+      modifications?: Array<DesignedProteinEntity.Modification>;
     }
 
     export namespace DesignedProteinEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -5025,20 +4641,6 @@ export namespace DesignEstimateCostParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     /**
@@ -5065,11 +4667,11 @@ export namespace DesignEstimateCostParams {
       /**
        * Optional polymer modifications. Defaults to [] when omitted.
        */
-      modifications?: Array<FixedProteinEntity.CcdModification | FixedProteinEntity.SmilesModification>;
+      modifications?: Array<FixedProteinEntity.Modification>;
     }
 
     export namespace FixedProteinEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -5083,20 +4685,6 @@ export namespace DesignEstimateCostParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface FixedRnaEntity {
@@ -5120,11 +4708,11 @@ export namespace DesignEstimateCostParams {
       /**
        * Optional polymer modifications. Defaults to [] when omitted.
        */
-      modifications?: Array<FixedRnaEntity.CcdModification | FixedRnaEntity.SmilesModification>;
+      modifications?: Array<FixedRnaEntity.Modification>;
     }
 
     export namespace FixedRnaEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -5138,20 +4726,6 @@ export namespace DesignEstimateCostParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface FixedDnaEntity {
@@ -5175,11 +4749,11 @@ export namespace DesignEstimateCostParams {
       /**
        * Optional polymer modifications. Defaults to [] when omitted.
        */
-      modifications?: Array<FixedDnaEntity.CcdModification | FixedDnaEntity.SmilesModification>;
+      modifications?: Array<FixedDnaEntity.Modification>;
     }
 
     export namespace FixedDnaEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -5193,20 +4767,6 @@ export namespace DesignEstimateCostParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface FixedLigandSmilesEntity {
@@ -5569,11 +5129,11 @@ export namespace DesignEstimateCostParams {
        * Post-translational modifications. Optional; defaults to an empty list when
        * omitted.
        */
-      modifications?: Array<ProteinEntity.CcdModification | ProteinEntity.SmilesModification>;
+      modifications?: Array<ProteinEntity.Modification>;
     }
 
     export namespace ProteinEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -5587,20 +5147,6 @@ export namespace DesignEstimateCostParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface RnaEntity {
@@ -5624,11 +5170,11 @@ export namespace DesignEstimateCostParams {
       /**
        * Chemical modifications. Optional; defaults to an empty list when omitted.
        */
-      modifications?: Array<RnaEntity.CcdModification | RnaEntity.SmilesModification>;
+      modifications?: Array<RnaEntity.Modification>;
     }
 
     export namespace RnaEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -5642,20 +5188,6 @@ export namespace DesignEstimateCostParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface DnaEntity {
@@ -5679,11 +5211,11 @@ export namespace DesignEstimateCostParams {
       /**
        * Chemical modifications. Optional; defaults to an empty list when omitted.
        */
-      modifications?: Array<DnaEntity.CcdModification | DnaEntity.SmilesModification>;
+      modifications?: Array<DnaEntity.Modification>;
     }
 
     export namespace DnaEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -5697,20 +5229,6 @@ export namespace DesignEstimateCostParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface LigandCcdEntity {
@@ -6265,11 +5783,11 @@ export namespace DesignStartParams {
       /**
        * Optional polymer modifications. Defaults to [] when omitted.
        */
-      modifications?: Array<DesignedProteinEntity.CcdModification | DesignedProteinEntity.SmilesModification>;
+      modifications?: Array<DesignedProteinEntity.Modification>;
     }
 
     export namespace DesignedProteinEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -6283,20 +5801,6 @@ export namespace DesignStartParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     /**
@@ -6323,11 +5827,11 @@ export namespace DesignStartParams {
       /**
        * Optional polymer modifications. Defaults to [] when omitted.
        */
-      modifications?: Array<FixedProteinEntity.CcdModification | FixedProteinEntity.SmilesModification>;
+      modifications?: Array<FixedProteinEntity.Modification>;
     }
 
     export namespace FixedProteinEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -6341,20 +5845,6 @@ export namespace DesignStartParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface FixedRnaEntity {
@@ -6378,11 +5868,11 @@ export namespace DesignStartParams {
       /**
        * Optional polymer modifications. Defaults to [] when omitted.
        */
-      modifications?: Array<FixedRnaEntity.CcdModification | FixedRnaEntity.SmilesModification>;
+      modifications?: Array<FixedRnaEntity.Modification>;
     }
 
     export namespace FixedRnaEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -6396,20 +5886,6 @@ export namespace DesignStartParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface FixedDnaEntity {
@@ -6433,11 +5909,11 @@ export namespace DesignStartParams {
       /**
        * Optional polymer modifications. Defaults to [] when omitted.
        */
-      modifications?: Array<FixedDnaEntity.CcdModification | FixedDnaEntity.SmilesModification>;
+      modifications?: Array<FixedDnaEntity.Modification>;
     }
 
     export namespace FixedDnaEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -6451,20 +5927,6 @@ export namespace DesignStartParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface FixedLigandSmilesEntity {
@@ -6827,11 +6289,11 @@ export namespace DesignStartParams {
        * Post-translational modifications. Optional; defaults to an empty list when
        * omitted.
        */
-      modifications?: Array<ProteinEntity.CcdModification | ProteinEntity.SmilesModification>;
+      modifications?: Array<ProteinEntity.Modification>;
     }
 
     export namespace ProteinEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -6845,20 +6307,6 @@ export namespace DesignStartParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface RnaEntity {
@@ -6882,11 +6330,11 @@ export namespace DesignStartParams {
       /**
        * Chemical modifications. Optional; defaults to an empty list when omitted.
        */
-      modifications?: Array<RnaEntity.CcdModification | RnaEntity.SmilesModification>;
+      modifications?: Array<RnaEntity.Modification>;
     }
 
     export namespace RnaEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -6900,20 +6348,6 @@ export namespace DesignStartParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface DnaEntity {
@@ -6937,11 +6371,11 @@ export namespace DesignStartParams {
       /**
        * Chemical modifications. Optional; defaults to an empty list when omitted.
        */
-      modifications?: Array<DnaEntity.CcdModification | DnaEntity.SmilesModification>;
+      modifications?: Array<DnaEntity.Modification>;
     }
 
     export namespace DnaEntity {
-      export interface CcdModification {
+      export interface Modification {
         /**
          * 0-based index of the residue to modify
          */
@@ -6955,20 +6389,6 @@ export namespace DesignStartParams {
          */
         value: string;
       }
-
-      export interface SmilesModification {
-        /**
-         * 0-based index of the residue to modify
-         */
-        residue_index: number;
-
-        type: 'smiles';
-
-        /**
-         * SMILES string for the modification
-         */
-        value: string;
-      }
     }
 
     export interface LigandCcdEntity {