@sjcrh/proteinpaint-client 2.77.0 → 2.78.0

package/dist/app-488d9fd6.js

@@ -0,0 +1 @@
+function e(e,t){if(t===void 0)t={};var n=t.insertAt;if(!e||typeof document==="undefined"){return}var r=document.head||document.getElementsByTagName("head")[0];var o=document.createElement("style");o.type="text/css";if(n==="top"){if(r.firstChild){r.insertBefore(o,r.firstChild)}else{r.appendChild(o)}}else{r.appendChild(o)}if(o.styleSheet){o.styleSheet.cssText=e}else{o.appendChild(document.createTextNode(e))}}var t='\n/**\n * Render the `main` element consistently in IE.\n */\n\n.sja_root_holder main, .sja_menu_div main, .sja_pane main {\n  display: block;\n}\n\n/**\n * Correct the font size and margin on `h1` elements within `section` and\n * `article` contexts in Chrome, Firefox, and Safari.\n */\n\n.sja_root_holder h1, .sja_menu_div h1, .sja_pane h1 {\n  font-size: 2em;\n  margin: 0.67em 0;\n}\n\n/* Grouping content\n   ========================================================================== */\n\n/**\n * 1. Add the correct box sizing in Firefox.\n * 2. Show the overflow in Edge and IE.\n */\n\n.sja_root_holder hr, .sja_menu_div hr, .sja_pane hr {\n  box-sizing: content-box; /* 1 */\n  height: 0; /* 1 */\n  overflow: visible; /* 2 */\n}\n\n/**\n * 1. Correct the inheritance and scaling of font size in all browsers.\n * 2. Correct the odd `em` font sizing in all browsers.\n */\n\n.sja_root_holder pre, .sja_menu_div pre, .sja_pane pre {\n  font-family: monospace, monospace; /* 1 */\n  font-size: 1em; /* 2 */\n}\n\n/* Text-level semantics\n   ========================================================================== */\n\n/**\n * Remove the gray background on active links in IE 10.\n */\n\n.sja_root_holder a, .sja_menu_div a, .sja_pane a {\n  background-color: transparent;\n}\n\n/**\n * 1. Remove the bottom border in Chrome 57-\n * 2. Add the correct text decoration in Chrome, Edge, IE, Opera, and Safari.\n */\n\n.sja_root_holder abbr[title], .sja_menu_div abbr[title], .sja_pane abbr[title] {\n  border-bottom: none; /* 1 */\n  text-decoration: underline; /* 2 */\n  text-decoration: underline dotted; /* 2 */\n}\n\n/**\n * Add the correct font weight in Chrome, Edge, and Safari.\n */\n\n.sja_root_holder b, .sja_menu_div b, .sja_pane b,\n.sja_root_holder strong, .sja_menu_div strong, .sja_pane strong {\n  font-weight: bolder;\n}\n\n/**\n * 1. Correct the inheritance and scaling of font size in all browsers.\n * 2. Correct the odd `em` font sizing in all browsers.\n */\n\n.sja_root_holder code, .sja_menu_div code, .sja_pane code,\n.sja_root_holder kbd, .sja_menu_div kbd, .sja_pane kbd,\n.sja_root_holder samp, .sja_menu_div samp, .sja_pane samp {\n  font-family: monospace, monospace; /* 1 */\n  font-size: 1em; /* 2 */\n}\n\n/**\n * Add the correct font size in all browsers.\n */\n\n.sja_root_holder small, .sja_menu_div small, .sja_pane small {\n  font-size: 80%;\n}\n\n/**\n * Prevent `sub` and `sup` elements from affecting the line height in\n * all browsers.\n */\n\n.sja_root_holder sub, .sja_menu_div sub, .sja_pane sub,\n.sja_root_holder sup, .sja_menu_div sup, .sja_pane sup {\n  font-size: 75%;\n  line-height: 0;\n  position: relative;\n  vertical-align: baseline;\n}\n\n.sja_root_holder sub, .sja_menu_div sub, .sja_pane sub {\n  bottom: -0.25em;\n}\n\n.sja_root_holder sup, .sja_menu_div sup, .sja_pane sup {\n  top: -0.5em;\n}\n\n/* Embedded content\n   ========================================================================== */\n\n/**\n * Remove the border on images inside links in IE 10.\n */\n\n.sja_root_holder img, .sja_menu_div img, .sja_pane img {\n  border-style: none;\n}\n\n/* Forms\n   ========================================================================== */\n\n/**\n * 1. Change the font styles in all browsers.\n * 2. Remove the margin in Firefox and Safari.\n */\n\n.sja_root_holder button, .sja_menu_div button, .sja_pane button,\n.sja_root_holder input, .sja_menu_div input, .sja_pane input,\n.sja_root_holder optgroup, .sja_menu_div optgroup, .sja_pane optgroup,\n.sja_root_holder select, .sja_menu_div select, .sja_pane select,\n.sja_root_holder textarea, .sja_menu_div textarea, .sja_pane textarea {\n  font-family: inherit; /* 1 */\n  font-size: 100%; /* 1 */\n  line-height: 1.15; /* 1 */\n  margin: 0; /* 2 */\n}\n\n/**\n * Show the overflow in IE.\n * 1. Show the overflow in Edge.\n */\n\n.sja_root_holder button, .sja_menu_div button, .sja_pane button,\n.sja_root_holder input  /* 1 */, .sja_menu_div input  /* 1 */, .sja_pane input  /* 1 */ {\n  overflow: visible;\n}\n\n/**\n * Remove the inheritance of text transform in Edge, Firefox, and IE.\n * 1. Remove the inheritance of text transform in Firefox.\n */\n\n.sja_root_holder button, .sja_menu_div button, .sja_pane button,\n.sja_root_holder select  /* 1 */, .sja_menu_div select  /* 1 */, .sja_pane select  /* 1 */ {\n  text-transform: none;\n}\n\n/**\n * Correct the inability to style clickable types in iOS and Safari.\n */\n\n.sja_root_holder button, .sja_menu_div button, .sja_pane button,\n.sja_root_holder [type="button"], .sja_menu_div [type="button"], .sja_pane [type="button"],\n.sja_root_holder [type="reset"], .sja_menu_div [type="reset"], .sja_pane [type="reset"],\n.sja_root_holder [type="submit"], .sja_menu_div [type="submit"], .sja_pane [type="submit"] {\n  -webkit-appearance: button;\n}\n\n/**\n * Remove the inner border and padding in Firefox.\n */\n\n.sja_root_holder button::-moz-focus-inner, .sja_menu_div button::-moz-focus-inner, .sja_pane button::-moz-focus-inner,\n.sja_root_holder [type="button"]::-moz-focus-inner, .sja_menu_div [type="button"]::-moz-focus-inner, .sja_pane [type="button"]::-moz-focus-inner,\n.sja_root_holder [type="reset"]::-moz-focus-inner, .sja_menu_div [type="reset"]::-moz-focus-inner, .sja_pane [type="reset"]::-moz-focus-inner,\n.sja_root_holder [type="submit"]::-moz-focus-inner, .sja_menu_div [type="submit"]::-moz-focus-inner, .sja_pane [type="submit"]::-moz-focus-inner {\n  border-style: none;\n  padding: 0;\n}\n\n/**\n * Restore the focus styles unset by the previous rule.\n */\n\n.sja_root_holder button:-moz-focusring, .sja_menu_div button:-moz-focusring, .sja_pane button:-moz-focusring,\n.sja_root_holder [type="button"]:-moz-focusring, .sja_menu_div [type="button"]:-moz-focusring, .sja_pane [type="button"]:-moz-focusring,\n.sja_root_holder [type="reset"]:-moz-focusring, .sja_menu_div [type="reset"]:-moz-focusring, .sja_pane [type="reset"]:-moz-focusring,\n.sja_root_holder [type="submit"]:-moz-focusring, .sja_menu_div [type="submit"]:-moz-focusring, .sja_pane [type="submit"]:-moz-focusring {\n  outline: 1px dotted ButtonText;\n}\n\n/**\n * Correct the padding in Firefox.\n */\n\n.sja_root_holder fieldset, .sja_menu_div fieldset, .sja_pane fieldset {\n  padding: 0.35em 0.75em 0.625em;\n}\n\n/**\n * 1. Correct the text wrapping in Edge and IE.\n * 2. Correct the color inheritance from `fieldset` elements in IE.\n * 3. Remove the padding so developers are not caught out when they zero out\n *    `fieldset` elements in all browsers.\n */\n\n.sja_root_holder legend, .sja_menu_div legend, .sja_pane legend {\n  box-sizing: border-box; /* 1 */\n  color: inherit; /* 2 */\n  display: table; /* 1 */\n  max-width: 100%; /* 1 */\n  padding: 0; /* 3 */\n  white-space: normal; /* 1 */\n}\n\n/**\n * Add the correct vertical alignment in Chrome, Firefox, and Opera.\n */\n\n.sja_root_holder progress, .sja_menu_div progress, .sja_pane progress {\n  vertical-align: baseline;\n}\n\n/**\n * Remove the default vertical scrollbar in IE 10+.\n */\n\n.sja_root_holder textarea, .sja_menu_div textarea, .sja_pane textarea {\n  overflow: auto;\n}\n\n/**\n * 1. Add the correct box sizing in IE 10.\n * 2. Remove the padding in IE 10.\n */\n\n.sja_root_holder [type="checkbox"], .sja_menu_div [type="checkbox"], .sja_pane [type="checkbox"],\n.sja_root_holder [type="radio"], .sja_menu_div [type="radio"], .sja_pane [type="radio"] {\n  box-sizing: border-box; /* 1 */\n  padding: 0; /* 2 */\n}\n\n/**\n * Correct the cursor style of increment and decrement buttons in Chrome.\n */\n\n.sja_root_holder [type="number"]::-webkit-inner-spin-button, .sja_menu_div [type="number"]::-webkit-inner-spin-button, .sja_pane [type="number"]::-webkit-inner-spin-button,\n.sja_root_holder [type="number"]::-webkit-outer-spin-button, .sja_menu_div [type="number"]::-webkit-outer-spin-button, .sja_pane [type="number"]::-webkit-outer-spin-button {\n  height: auto;\n}\n\n/**\n * 1. Correct the odd appearance in Chrome and Safari.\n * 2. Correct the outline style in Safari.\n */\n\n.sja_root_holder [type="search"], .sja_menu_div [type="search"], .sja_pane [type="search"] {\n  -webkit-appearance: textfield; /* 1 */\n  outline-offset: -2px; /* 2 */\n}\n\n/**\n * Remove the inner padding in Chrome and Safari on macOS.\n */\n\n.sja_root_holder [type="search"]::-webkit-search-decoration, .sja_menu_div [type="search"]::-webkit-search-decoration, .sja_pane [type="search"]::-webkit-search-decoration {\n  -webkit-appearance: none;\n}\n\n/**\n * 1. Correct the inability to style clickable types in iOS and Safari.\n * 2. Change font properties to `inherit` in Safari.\n */\n\n.sja_root_holder ::-webkit-file-upload-button, .sja_menu_div ::-webkit-file-upload-button, .sja_pane ::-webkit-file-upload-button {\n  -webkit-appearance: button; /* 1 */\n  font: inherit; /* 2 */\n}\n\n/* Interactive\n   ========================================================================== */\n\n/*\n * Add the correct display in Edge, IE 10+, and Firefox.\n */\n\n.sja_root_holder details, .sja_menu_div details, .sja_pane details {\n  display: block;\n}\n\n/*\n * Add the correct display in all browsers.\n */\n\n.sja_root_holder summary, .sja_menu_div summary, .sja_pane summary {\n  display: list-item;\n}\n\n/* Misc\n   ========================================================================== */\n\n/**\n * Add the correct display in IE 10+.\n */\n\n.sja_root_holder template, .sja_menu_div template, .sja_pane template {\n  display: none;\n}\n\n/**\n * Add the correct display in IE 10.\n */\n\n.sja_root_holder [hidden], .sja_menu_div [hidden], .sja_pane [hidden] {\n  display: none;\n}';e(t);var n="pre code.hljs{display:block;overflow-x:auto;padding:1em}code.hljs{padding:3px 5px}/*!\n  Theme: GitHub\n  Description: Light theme as seen on github.com\n  Author: github.com\n  Maintainer: @Hirse\n  Updated: 2021-05-15\n\n  Outdated base version: https://github.com/primer/github-syntax-light\n  Current colors taken from GitHub's CSS\n*/.hljs{color:#24292e;background:#fff}.hljs-doctag,.hljs-keyword,.hljs-meta .hljs-keyword,.hljs-template-tag,.hljs-template-variable,.hljs-type,.hljs-variable.language_{color:#d73a49}.hljs-title,.hljs-title.class_,.hljs-title.class_.inherited__,.hljs-title.function_{color:#6f42c1}.hljs-attr,.hljs-attribute,.hljs-literal,.hljs-meta,.hljs-number,.hljs-operator,.hljs-selector-attr,.hljs-selector-class,.hljs-selector-id,.hljs-variable{color:#005cc5}.hljs-meta .hljs-string,.hljs-regexp,.hljs-string{color:#032f62}.hljs-built_in,.hljs-symbol{color:#e36209}.hljs-code,.hljs-comment,.hljs-formula{color:#6a737d}.hljs-name,.hljs-quote,.hljs-selector-pseudo,.hljs-selector-tag{color:#22863a}.hljs-subst{color:#24292e}.hljs-section{color:#005cc5;font-weight:700}.hljs-bullet{color:#735c0f}.hljs-emphasis{color:#24292e;font-style:italic}.hljs-strong{color:#24292e;font-weight:700}.hljs-addition{color:#22863a;background-color:#f0fff4}.hljs-deletion{color:#b31d28;background-color:#ffeef0}";e(n);var r="/*\n    see client/generateScopedCss.js on how to generate style-normalize-*.css\n\n    also see a TODO comment in client/src/app.js, of dynamically importing\n    style-normalize-unscoped.css only if it's known to not conflict in\n    the embedder portal\n*/\n/* directly import these in src/app.js so that they will be processed as CSSStyleSheet\n@import './style-normalize-scoped.css';\n@import 'highlight.js/styles/github.css';\n*/\n/*\nhtml {\n    height:100%;\n}\nbody {\n    min-height:100%;\n}\ntable {\n    font-size:1em;\n    border-spacing:1px;\n    border-collapse:separate;\n}\n*/\n/*\n    !!! NOTE !!!\n    FireFox does not support the @scope (selector) syntax\n    that can enclose all affected rules inside a nested block,\n    so for now, will need to prepend the .sja_root_holder scope for each selector\n*/\n/***************************************\nCSS properties that are not covered \nby normalize.css are covered here\n\n!!! make sure to scope to sja_root_holder\n****************************************/\n.sja_root_holder h2 {\n    margin-block-start: 0.83em;\n    margin-block-end: 0.83em;\n}\n/***************************************\n    tag-based styles\n\n  prevent embedder styles from overriding\n  the styles within pp-controlled divs\n****************************************/\n/* use default browser styles within pp-controlled divs */\n/* using the !important flag:\n- this flag is used to override conflicting styles\n- this flag will override both embedder styling and inline styling\n- it is not necessary to use this flag to prevent embedder styles from overriding pp styles, because specifying styles within pp-specific classes will usually prevent this issue\n- the only time when it is necessary to use this flag is when (1) the conflicting styling also has an !important flag or (2) the conflicting styling is also specified in this same file\n*/\n.sja_root_holder {\n    /*background-color: #fff;*/\n}\n.sja_root_holder,\n.sja_menu_div,\n.sja_pane {\n    all: initial;\n    /* block inheritance for all properties */\n}\n.sja_root_holder table,\n.sja_menu_div table,\n.sja_pane table {\n    border-collapse: separate;\n    border-spacing: 2px;\n}\n.sja_root_holder svg {\n    display: inline-block;\n}\n/*\n    override the thicker button border\n    that results when a button's \n    border-radius: 0 which seems to override\n    all associated styles of \n    -webkit-appearance: button;\n*/\n.sja_root_holder button,\n.sja_menu_div button,\n.sja_pane button {\n    padding: 2px 3px;\n    border-width: 1px;\n    border-style: solid;\n    border-radius: 3px;\n    box-shadow: inset 0 0 0 99999px rgba(255, 255, 255, 0.3);\n    font-family: Arial;\n    color: black;\n    background-color: buttonface;\n    border-color: buttonborder;\n}\n.sja_root_holder button:disabled,\n.sja_menu_div button:disabled,\n.sja_pane button:disabled {\n    background-color: rgba(239, 239, 239, 0.3);\n    color: rgba(16, 16, 16, 0.3);\n    border-color: rgba(118, 118, 118, 0.3);\n}\n.sja_root_holder button:hover,\n.sja_menu_div button:hover,\n.sja_pane button:hover {\n    box-shadow: none;\n}\n.sja_root_holder label,\n.sja_menu_div label,\n.sja_pane label {\n    margin-bottom: 0;\n}\n.sja_root_holder a,\n.sja_menu_div a,\n.sja_pane a,\n.linkText {\n    color: rgb(0, 0, 238);\n    cursor: pointer;\n    text-decoration: underline;\n}\n.sja_root_holder input,\n.sja_menu_div input,\n.sja_pane input {\n    padding: 1px 3px;\n    margin:  2px 5px;\n    border:  1px solid #ccc;\n}\n.sja_root_holder select,\n.sja_menu_div select,\n.sja_pane select {\n    padding: 1px 3px;\n    padding-right: 30px; /* padding between text and arrow */\n    background-size: auto;\n    background-position: right;\n    border: 1px solid #ccc;\n}\n.sja_root_holder textarea,\n.sja_menu_div textarea,\n.sja_pane textarea {\n    padding: 2px;\n    border: 1px solid #ccc;\n}\n.sja_root_holder input[type=\"search\"].tree_search {\n    -webkit-appearance: searchfield;\n}\n.sja_root_holder ul {\n    display: block;\n    list-style-type: disc;\n    margin-block-start: 1em;\n    margin-block-end: 1em;\n    margin-inline-start: 0px;\n    margin-inline-end: 0px;\n    padding-inline-start: 40px;\n}\n.sja_root_holder ul ul {\n    list-style-type: circle;\n}\n.sja_root_holder li {\n    display: list-item;\n    text-align: -webkit-match-parent;\n}\n/*************************\n    class-specific styles\n*************************/\n.sja_errorbar {\n    position: relative;\n    padding: 5px 50px 5px 10px;\n    background-color: rgba(200, 0, 0, .1);\n    color: rgba(190, 0, 0, .5);\n    border: solid 1px rgba(200, 0, 0, .2);\n    /*border-width: 1px 0px;*/\n}\n.sja_errorbar>:nth-child(2) {\n    position: absolute;\n    padding: 5px 10px;\n    cursor: default;\n    top: 0px;\n    right: 10px;\n}\n.sja_inset_a {\n    background-color: #ebedeb;\n    box-shadow: inset 0px 0px 14px 0px #858585;\n    padding: 5px 10px;\n}\n.sja_menu,\n.sja_menu_persist,\n.sja_tooltip {\n    position: absolute;\n    background-color: white;\n    font-family: Arial;\n    z-index: 1000;\n}\n/* /client/src/app.js start */\n.sja_menuoption {\n    color: black;\n    padding: 5px 10px;\n    cursor: default;\n    background-color: #f2f2f2;\n    margin: 1px;\n    border-radius: 5px;\n}\n.sja_menuoption_not_interactive {\n    padding: 5px 10px;\n    cursor: default;\n    margin: 1px;\n}\n.sja_sharp_border {\n    border-radius: 0px;\n}\n.sja_menuoption:hover {\n    background-color: #e6e6e6\n}\n.sja_menuoption:active {\n    color: #cc0000;\n    background-color: #FCE2E1;\n}\n/* /client/src/app.js end */\n.sja_filter_tag_btn {\n    display: inline-block;\n    color: black;\n    padding: 5px 8px;\n    background-color: #cfe2f3;\n    cursor: default;\n}\n/* .sja_filter_tag_btn:hover { opacity: 0.8; cursor:default} */\n.sja_filter_tag_btn:active {\n    color: #cc0000;\n    opacity: 0.6;\n}\n.ts_pill:hover,\n.tvs_pill:hover {\n    opacity: 0.8;\n    cursor: default\n}\n.sjpp_apply_btn {\n    background-color: #d0e0e3;\n    border-radius: 13px !important; \n    padding: 7px 15px !important;\n    border: 0px !important;\n}\n.sjpp_delete_btn,\n.remove_btn {\n    background-color: #f4cccc;\n}\n.ts_summary_btn {\n    background-color: #d9d2e9;\n}\n/* mostly for table tr */\n.sja_clb {\n    padding: 5px 10px;\n    cursor: default;\n}\n.sja_clb:hover {\n    background: #ffff99;\n}\n.sja_clb:active {\n    background: #ffcc99;\n}\n.sja_clb_selected {\n    padding: 5px 10px;\n    cursor: default;\n    background: #FAF0C8;\n    border-bottom: solid 2px #E3CA64;\n}\n.sja_clb_selected:hover {\n    background: #FCE68B\n}\n.sja_clb_selected:active {\n    background: #ffcc99\n}\n/* table tr, gray highlight */\n.sja_clb_gray {\n    padding: 5px 10px;\n    cursor: default;\n}\n.sja_clb_gray:hover {\n    background-color: #f1f1f1;\n}\n.sja_clb_gray:active {\n    background-color: #ffffcc;\n}\n.sja_hideable_legend {\n    cursor: default;\n}\n.sja_hideable_legend:hover {\n    background: #ffff99;\n}\n.sja_legend_more_btn {\n    padding: 3px;\n    text-align: center;\n    font-size: 0.7em;\n    opacity: 0.5;\n    cursor: default;\n}\n.sja_legend_more_btn:hover {\n    text-decoration: underline;\n}\n/* text only */\n.sja_clbtext2 {\n    cursor: default;\n    text-decoration: none;\n}\n.sja_clbtext2:hover {\n    text-decoration: underline;\n}\n.sja_clbtext2:active {\n    fill: #CC0000;\n    color: #CC0000;\n}\n.sja_clbtext {\n    cursor: default;\n    color: black;\n    fill: black;\n    border-bottom: solid 1px transparent;\n}\n.sja_clbtext:hover {\n    color: #631318;\n    fill: #631318;\n    border-color: black;\n}\n.sja_clbtext:active {\n    color: #CC0000;\n    border-color: #cc0000;\n    fill: #cc0000;\n}\n.sja_clbtextbold {\n    cursor: default;\n    color: black;\n    fill: black;\n    font-weight: normal;\n}\n.sja_clbtextbold:hover {\n    color: #631318;\n    fill: #631318;\n    font-weight: bold;\n}\n.sja_clbtextbold:active {\n    color: #CC0000;\n    fill: #cc0000;\n    font-weight: bold;\n}\n.sja_opaque6 {\n    opacity: .6;\n    cursor: default;\n}\n.sja_opaque6:hover {\n    opacity: .9;\n}\n.sja_opaque8 {\n    opacity: .8;\n    cursor: default;\n}\n.sja_opaque8:hover {\n    opacity: 1;\n}\n.sja_simpletable tr td {\n    border-bottom: solid 1px #ededed;\n}\n.sja_mcdot {\n    cursor: default;\n    border-radius: 8px;\n    padding: 1px 2px;\n    margin-right: 1px;\n    color: white;\n    font-size: .8em;\n}\n.sja_variantpagesnv {\n    cursor: default;\n    display: inline-block;\n    border-radius: 3px;\n    padding: 3px 10px;\n    margin-right: 2px;\n    color: white;\n    background-color: #0099FF;\n    opacity: .6;\n}\n.sja_variantpagesnv:hover {\n    opacity: 1;\n}\n.sja_variantpagesnv:active {\n    background-color: #3366FF;\n}\n.sja_selectsample {\n    cursor: default;\n    display: inline-block;\n    border-radius: 2px;\n    border: solid 1px #545454;\n    padding: 3px 10px;\n    margin-right: 2px;\n    color: #545454;\n    background-color: white;\n    font-size: .8em;\n}\n.sja_selectsample:hover {\n    background-color: #f1f1f1;\n}\n.sja_selectsample:active {\n    background-color: #F2E1E3;\n}\n.sja_pane {\n    position: absolute;\n    /*border:solid 1px #ccc;\n    */\n    box-shadow: 0px 2px 4px 1px #999;\n    background-color: white;\n}\n.sja_pane>:first-child {\n    padding-right: 10px;\n    cursor: move;\n    background-color: #f0f0f0;\n}\n.sja_pane>:nth-child(2) {\n    padding: 0px 10px 10px 10px;\n    font-family: Arial;\n}\n.sja_cursor_hmove {\n    cursor: ew-resize;\n}\n.sja_svgtext {\n    cursor: default;\n    fill-opacity: .8\n}\n.sja_svgtext2 {\n    cursor: default;\n    fill: black;\n}\n.sja_svgtext2:hover {\n    fill: #B30000\n}\n.sja_clb5 {\n    /* tree button */\n    cursor: default;\n    display: inline-block;\n    border: solid 1px #006600;\n    color: #006600;\n    background-color: white;\n    margin-left: 6px;\n    padding: 0px 4px;\n    font-size: 80%;\n}\n.sja_clb5:hover {\n    background-color: #006600;\n    color: white;\n}\n.sja_clb5:active {\n    background-color: #009900;\n}\n.sja_clb2 {\n    color: black;\n    font-family: Courier;\n    display: inline-block;\n    padding: 1px 5px;\n    cursor: default;\n}\n.sja_clb2:hover {\n    background-color: #ffff99;\n}\n.sja_clb2:active {\n    background-color: #ccff99;\n}\n.sja_clbb {\n    /* highlight border */\n    border: solid 1px transparent;\n    cursor: default;\n}\n.sja_clbb:hover {\n    border-color: #ccc;\n}\n.sja_clbbox {\n    cursor: default;\n    padding: 2px 5px;\n    color: white;\n    font-size: .7em;\n    font-weight: normal;\n}\n.sja_clbbox:hover {\n    font-weight: bold;\n}\n.sja_tr {\n    cursor: default;\n    background-color: #f1f1f1;\n}\n.sja_tr:hover {\n    background-color: white;\n}\n.sja_tr:active {\n    background-color: #ffffcc;\n}\n.sja_tr2 {\n    cursor: default;\n}\n.sja_tr2:hover {\n    background-color: #ffffcc;\n}\n.sja_tr2:active {\n    background-color: #ffff00;\n}\n.sja_aa_disclabel {\n    cursor: default;\n}\n.sja_aa_discnum {\n    cursor: default;\n    text-rendering: geometricPrecision;\n}\n.sja_aa_skkick:hover {\n    stroke: #858585;\n}\n.sja_aa_disckick:hover {\n    stroke-opacity: 1;\n}\n.sja_menuoption_y {\n    display: inline-block;\n    color: black;\n    padding: 2px 4px;\n    cursor: default;\n    background-color: #E6E5C5;\n    margin: 2px;\n}\n.sja_menuoption_y:hover {\n    background-color: #DEDCA9\n}\n.sja_menuoption_y:active {\n    background-color: #FFFF99\n}\n.sja_menuoption_r {\n    display: inline-block;\n    color: black;\n    padding: 2px 4px;\n    cursor: default;\n    background-color: #EDDDDE;\n    margin: 2px;\n}\n.sja_menuoption_r:hover {\n    background-color: #E8CFD1\n}\n.sja_menuoption_r:active {\n    background-color: #FCD9DD\n}\n.sja_error2 {\n    display: inline-block;\n    padding: 5px 50px 5px 10px;\n    margin: 10px 20px;\n    background-color: rgba(200, 0, 0, .5);\n    color: white;\n    border-radius: 6px;\n}\n.sja_paint {\n    position: relative;\n}\n.sja_paint>:first-child {}\n.sja_paint>:nth-child(2) {\n    position: absolute;\n    padding: 3px 6px;\n    cursor: default;\n    top: 10px;\n    right: 30px;\n    font-size: 80%;\n}\n.sja_tree_ul {\n    list-style-type: none;\n    padding-left: 25px;\n    line-height: 1.4;\n}\n.sja_input {\n    display: inline-block;\n    padding: 2px 6px;\n}\n.sja_bulkcell {\n    display: inline-block;\n    width: 3px;\n    height: 9px;\n    margin: 1px 1px 0px 0px;\n}\n.sja_tag {\n    display: inline-block;\n    margin-left: 10px;\n    padding: 1px 3px;\n    background-color: #858585;\n    color: white;\n    font-size: 80%;\n}\n.sja_bgbox {\n    cursor: default;\n    fill: yellow;\n    fill-opacity: 0;\n}\n.sja_bgbox:hover {\n    fill-opacity: .2;\n}\n.sja_diseasehm_search_item {\n    display: inline-block;\n    margin: 3px;\n    padding: 2px;\n}\n.sja_pulse {\n    animation: pulse .5s alternate infinite;\n}\n@keyframes pulse {\n    from {\n        opacity: .2;\n    }\n    to {\n        opacity: 1;\n    }\n}\n.sja_hm-edittool-table td {\n    padding: 0 2px;\n    cursor: pointer;\n    text-align: center;\n    font-size: 14px;\n}\n.sja_hm-edittool-table td:hover {\n    opacity: 1;\n    font-weight: 600;\n}\n.sja_tinylogo_head {\n    display: inline-block;\n    background-color: #858585;\n    color: white;\n    font-size: .6em;\n    padding: 1px 3px;\n}\n.sja_tinylogo_body {\n    display: inline-block;\n    margin-left: 10px;\n    background-color: #ededed;\n    font-size: .9em;\n    color: black;\n    padding: 1px 5px;\n}\n.sja_handle_green {\n    display: inline-block;\n    font-size: .9em;\n    padding: 3px 6px;\n    background-color: #f0f7f1;\n    color: #146E17;\n    cursor: default;\n}\n.sja_handle_green:hover {\n    background-color: #D5F0D8;\n}\n.sja_handle_green:active {\n    background-color: #BAD1BC;\n    color: black;\n}\n.sja_handle_red {\n    display: inline-block;\n    font-size: .9em;\n    padding: 3px 6px;\n    background-color: #F5EBEC;\n    color: #991F1F;\n    cursor: default;\n}\n.sja_handle_red:hover {\n    background-color: #F2D8DB;\n}\n.sja_handle_red:active {\n    background-color: #E3B1B7;\n    color: black;\n}\n.sja_btn {\n    -webkit-appearance: button;\n    -moz-appearance: button;\n    appearance: button;\n    text-decoration: none;\n    color: initial;\n}\n.sja_button {\n    display: inline-block;\n    background: white;\n    padding: 3px 5px;\n    border: solid 1px black;\n    opacity: .8;\n    cursor: default;\n}\n.sja_button:hover {\n    opacity: 1;\n}\n.sja_button_open {\n    display: inline-block;\n    background: #ddd;\n    padding: 3px 5px;\n    border: solid 1px black;\n    opacity: .8;\n    cursor: default;\n}\n.sja_button_open:hover {\n    opacity: 1;\n}\n.sja_button_fold {\n    display: inline-block;\n    background: #aaa;\n    color: white;\n    padding: 3px 5px;\n    border: solid 1px black;\n    opacity: .8;\n    cursor: default;\n}\n.sja_button_fold:hover {\n    opacity: 1;\n}\n.sja-termdb-config-row-label {\n    padding: 5px;\n    text-align: left;\n    vertical-align: middle;\n}\n.sjpp-controls-table {\n  margin-bottom: 10px;\n}\n.sjpp-controls-table > tr:hover {\n  /*font-weight: 600;*/\n  text-shadow:0px 0px 0.5px black;\n  background-color: rgba(239, 236, 149, 0.389);\n}\n.sja_edit_btn {\n    display: inline-block;\n    color: black;\n    background-color: #f2f2f2;\n    border-radius: 5px;\n    border: solid 1px #aaa;\n    padding: 5px 10px;\n    cursor: default;\n    margin: 1px;\n    font-size: 0.8em;\n    margin-left: 20px;\n}\n.sja_edit_btn:hover {\n    background-color: #e6e6e6\n}\n.sja_edit_btn:active {\n    color: #cc0000;\n    background-color: #FCE2E1;\n}\n/* App Drawer style */\n.sjpp-appdrawer-cols {\n    font-family: Verdana, Geneva, Tahoma, sans-serif;\n    font-weight: 500;\n    font-size: 17px;\n    text-align: left;\n    color: #324870;\n    margin: 10px 10px 0px 10px;\n}\n.sjpp-track, .sjpp-track li {\n    display: grid !important;\n    grid-template-columns: 2fr 4fr 40px;\n    grid-template-areas: 'image header' 'image blurb';\n    gap: 5px;\n}\n.sjpp-app-drawer-card,\n.sjpp-track {\n    background-color: white;\n    max-width: 400px;\n    /* min-width: 320px; */\n    border-radius: 5px;\n    padding: 0px;\n    align-items: center;\n    justify-items: left;\n    box-shadow: 0 1px 2px rgba(0, 0, 0, 0.1);\n    -webkit-transition: all 0.6s cubic-bezier(0.165, 0.84, 0.44, 1);\n    transition: all 0.6s cubic-bezier(0.165, 0.84, 0.44, 1);\n}\n.sjpp-app-drawer-card::after,\n.sjpp-track::after {\n    content: \"\";\n    border-radius: 8px;\n    position: absolute;\n    z-index: -1;\n    top: 0;\n    left: 0;\n    width: 100%;\n    height: 100%;\n    box-shadow: 0 5px 15px rgba(0, 0, 0, 0.3);\n    opacity: 0;\n    -webkit-transition: all 0.6s cubic-bezier(0.165, 0.84, 0.44, 1);\n    transition: all 0.6s cubic-bezier(0.165, 0.84, 0.44, 1);\n}\n.sjpp-app-drawer-card:hover,\n.sjpp-track:hover {\n    -webkit-transform: scale(1, 1);\n    transform: scale(1, 1);\n}\n.sjpp-app-drawer-card:hover::after,\n.sjpp-track:hover::after {\n    opacity: 1;\n}\n.sjpp-track-image {\n    grid-area: image;\n    width: 75px;\n    height: 75px;\n    align-self: start;\n    justify-self: start;\n}\n.sjpp-track-image img {\n    width: 100%;\n    height: 100%;\n    object-fit: cover;\n    border-radius: 5px 0px 0px 5px;\n}\n.sjpp-app-drawer-card-ribbon{\n    grid-area: image;\n    overflow: hidden;\n    width: 100%;\n    height: 100%;\n}\n.sjpp-app-drawer-card-ribbon::before,\n.sjpp-app-drawer-card-ribbon::after {\n  position: relative;\n  z-index: -1;\n  content: '';\n  display: block;\n  border-top-color: transparent;\n  border-left-color: transparent;\n}\n.sjpp-app-drawer-card-ribbon span {\n  position: relative;\n  display: block;\n  width: 100%;\n  padding: 1px 0;\n  border-color: transparent transparent transparent darkgray;\n  box-shadow: 0 2px 7.5px rgba(0, 0, 0, 0.3);\n  opacity: 1;\n  font-family: 'Lucida Sans', 'Lucida Sans Regular', 'Lucida Grande', 'Lucida Sans Unicode', Geneva, Verdana, sans-serif;\n  transform: rotate(-45deg);\n}\n.sjpp-app-drawer-card-ribbon::before {\n    top: 0;\n    right: 0;\n}\n.sjpp-app-drawer-card-ribbon::after {\n    bottom: 0;\n    left: 0;\n}\n.sjpp-track-h {\n    grid-area: header;\n    font-family: 'Lucida Sans', 'Lucida Sans Regular', 'Lucida Grande', 'Lucida Sans Unicode', Geneva, Verdana, sans-serif;\n    margin-left: 5px;\n    padding: 0px;\n}\n.sjpp-track-blurb {\n    grid-area: blurb;\n    font-size: 13px;\n    font-weight: 300;\n    margin-left: 5px;\n    justify-content: center;\n    font-style: oblique;\n    color: #403f3f;\n}\n/* client/src/block.js start */\n.sjpp-active-tiny-button {\n\tdisplay: inline-block;\n\tbackground-color: #1C5E86;\n\tfont-size: .8em;\n\tcolor: white;\n\tpadding: 1px 5px;\n\tmargin-right: 5px;\n\tborder-radius: 4px;\n}\n.sjpp-plus-button\n{\n    display: inline-block;\n    margin: 1px;\n    border: solid 1px #545454;\n    font-size: .9em;\n    cursor: default;\n    padding: 2px 5px;\n}\n.sjpp-dshandleholder\n{\n    display: inline-block;\n    margin: 1px;\n    border: solid 1px #545454;\n    font-size: .9em;\n    cursor: default;\n}\n.sjpp-dslabel\n{\n    display: inline-block;\n    color: black;\n    padding: 2px 4px;\n\n}\n/* client/src/block.js end */\n/* client/src/app.js start */\n.sjpp-input-div-gene-pos\n{\n    display: inline-block;\n    padding-right: 5px;\n}\n.sjpp-input-gene-pos\n{\n    border: solid 1px #545454;\n    padding: 6px 10px;\n    border-radius: 5px;\n}\n.sjpp-genome-select-div\n{\n    display: inline-block;\n    padding-left: 5px;\n}\n.sjpp-genome-select\n{\n    border-radius: 5px;\n    margin: 1px 20px 1px 10px;\n}\n.sjpp-output-sandbox-title\n{\n    border-radius:4px; \n    color:white; \n    background-color: #969696; \n    padding: 1px 5px; \n    display:inline-block; \n    font-size:0.8em; \n    margin-left:4px;\n}\n/* client/src/app.js end */\n/* client/dom/sandbox.ts start */\n.sjpp-output-sandbox-header\n{\n    display: inline-block;\n    margin: 5px 10px;\n    padding-right: 8px;\n    margin-bottom: 0px;\n    /* box-shadow:2px 0px 2px #f2f2f2; */\n    border-radius: 5px 5px 0 0;\n    /* background-color: #f2f2f2; */\n    z-index: 99;\n}\n.sjpp-output-sandbox-content\n{\n    margin: 5px 10px;\n    margin-top: 0px;\n    padding-right: 8px;\n    display: inline-block;\n    /* box-shadow: 2px 2px 10px #f2f2f2; */\n    border: solid 1px #ccc;\n    border-top: solid 1px white;\n    border-radius: 0  0 5px 5px;\n}\n.sjpp-output-sandbox-collapse-btn,\n.sjpp-output-sandbox-expand-btn,\n.sjpp-output-sandbox-close-bt\n{\n    /* display: inline-block; */\n    /* margin: 0px; */\n    /* border-right: solid 2px white; */\n    font-size: 16px;\n    cursor: default;\n}\n.sjpp-output-sandbox-close-bt {\n    border-radius: 5px 0 0 0;\n}\n/* \nSeparated padding for sandbox buttons to fix close button's\nright, white border not extending to total height of\nsandbox header\n*/\n.sjpp-output-sandbox-collapse-btn,\n.sjpp-output-sandbox-expand-btn {\n    padding: 4px 10px;\n}\n.sjpp-output-sandbox-close-bt {\n    padding: 8px 10px;\n}\n/* client/dom/sandbox.ts end */\n.sjpp_row_wrapper:hover {\n    background: #fcfcca !important; \n}\n/*.sjpp_row_wrapper:nth-child(odd) {background: rgb(237, 237, 237)}*/\n.sjpp_table_header {\n    font-family: 'Arial';\n    font-size: 1em;\n    text-align: left;\n    position: sticky;\n    top: 0;\n    opacity: 0.7;\n    font-weight: normal;\n}\n.sjpp_table_item {\n    padding: 3px 5px;\n    font-size: 1em;\n    text-align: left;\n}\n.sjpp_show_scrollbar{\n\t/* set to \"auto\" to avoid showing a gray track as non-functional scrollbar when contents don't scroll at all, since scrollbar track is now gray and no longer white */\n    overflow-y: auto;\n    overflow-x: auto;\n}\n.sjpp_show_scrollbar::-webkit-scrollbar{\n    background-color: #f1f1f1; /* use non-white track color so the presence of scrollbar is apparent (gdc requirement) */\n    border-radius: 7px;\n    width: 14px;\n}\n/* This will handle the thumb (scrolling part) */\n.sjpp_show_scrollbar::-webkit-scrollbar-thumb{\n    background-color: #858585;\n    border-radius: 7px;\n    border: 1px solid white;\n}\n.sjpp_show_scrollbar::-webkit-scrollbar-thumb:vertical{\n    height: 14px!important;\n    width: 14px;\n}\n.sjpp-matrix-series-group-label-g text,\n.sjpp-matrix-series-label-g text,\n.sjpp-matrix-term-group-label-g text,\n.sjpp-matrix-term-label-g text,\n.sjpp-matrix-label text {\n    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6px solid rgba(0, 174, 239, .8);\n    border-radius: 100%;\n}\n@-webkit-keyframes rotation {\n    from {-webkit-transform: rotate(0deg);}\n    to {-webkit-transform: rotate(359deg);}\n }\n@-moz-keyframes rotation {\n    from {-moz-transform: rotate(0deg);}\n    to {-moz-transform: rotate(359deg);}\n }\n@-o-keyframes rotation {\n    from {-o-transform: rotate(0deg);}\n    to {-o-transform: rotate(359deg);}\n }\n@keyframes rotation {\n    from {transform: rotate(0deg);}\n    to {transform: rotate(359deg);}\n }\n.sja_root_holder [aria-label], .sja_menu_div [aria-label], .sja_pane [aria-label] {\n    position: relative;\n    cursor: default;\n  }\n.sja_root_holder [aria-label]:after, .sja_menu_div [aria-label]:after, .sja_pane [aria-label]:after {\n    content: attr(aria-label);\n    position: absolute;\n    left: 1em;\n    top: 1.75em; /* put it on the top */\n    /*bottom: 50%;*/\n    background-color: white;\n    font-size: 15px;\n    padding: 5px;\n    opacity: 0;\n    z-index: 10000;\n    width: max-content;\n    max-width: 300px;\n    white-space: wrap;\n    pointer-events: none;\n    box-shadow: 0px 2px 4px 1px #999;\n    text-align: left;\n\n}\n.sja_root_holder [aria-label]:hover:after, .sja_menu_div [aria-label]:hover:after, .sja_pane [aria-label]:hover:after {\n    animation-name: fadeOut;\n    animation-duration: 5s;\n  }\n@keyframes fadeOut {\n    0% {\n      opacity: 1;\n    }\n    70% {\n      opacity: 1;\n    }\n    100% {\n      opacity: 0;\n    }\n  }";e(r);var o=".sja_root_holder .map, .sja_menu_div .map, .sja_pane .map {\n  width: 100%;\n  height: 400px;\n}\n\n.sja_root_holder .map .ol-custom-overviewmap, .sja_menu_div .map .ol-custom-overviewmap, .sja_pane .map .ol-custom-overviewmap,\n.sja_root_holder .map .ol-custom-overviewmap.ol-uncollapsible, .sja_menu_div .map .ol-custom-overviewmap.ol-uncollapsible, .sja_pane .map .ol-custom-overviewmap.ol-uncollapsible {\n  bottom: auto;\n  left: auto;\n  right: 6pt;\n  top: 6pt;\n}\n\n.sja_root_holder 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ua="CNV_loh";Ks[ua]={label:"LOH",color:"#12EDFC",dt:Gs,desc:"Loss of heterozygosity",key:ua};const pa="snv";Ks[pa]={label:"SNV",color:"#92a2d4",dt:Ps,desc:"Single nucleotide variation",key:pa};const ha="mnv";Ks[ha]={label:"MNV",color:"#92a2d4",dt:Ps,desc:"Multiple nucleotide variation",key:ha};const ma="insertion";Ks[ma]={label:"Sequence insertion",color:"#bd8e91",dt:Ps,desc:"Sequence insertion",key:ma};const ga="deletion";Ks[ga]={label:"Sequence deletion",color:"#b5a174",dt:Ps,desc:"Sequence deletion",key:ga};const ba={[Ps]:Ks.M.color};function ya(e={}){if(e.mclass){for(const t in e.mclass){if(!Ks[t])Ks[t]={};for(const n in e.mclass[t]){Ks[t][n]=e.mclass[t][n]}}}}const va=function(e){const t=e.toLowerCase().split(",");let n=1;if(t.indexOf("transcript_ablation")!=-1){return[Hs,ea,n]}n++;if(t.indexOf("splice_acceptor_variant")!=-1)return[Ps,"L",n];n++;if(t.indexOf("splice_donor_variant")!=-1)return[Ps,"L",n];n++;if(t.indexOf("stop_gained")!=-1)return[Ps,"N",n];n++;if(t.indexOf("frameshift_variant")!=-1)return[Ps,"F",n];n++;if(t.indexOf("stop_lost")!=-1)return[Ps,"N",n];n++;if(t.indexOf("start_lost")!=-1)return[Ps,"N",n];n++;if(t.indexOf("transcript_amplification")!=-1){return[Ps,ia,n]}n++;if(t.indexOf("inframe_insertion")!=-1||t.indexOf("conservative_inframe_insertion")!=-1||t.indexOf("disruptive_inframe_insertion")!=-1)return[Ps,"I",n];n++;if(t.indexOf("inframe_deletion")!=-1||t.indexOf("conservative_inframe_deletion")!=-1||t.indexOf("disruptive_inframe_deletion")!=-1)return[Ps,"D",n];n++;if(t.indexOf("missense_variant")!=-1)return[Ps,"M",n];n++;if(t.indexOf("protein_altering_variant")!=-1)return[Ps,"ProteinAltering",n];n++;if(t.indexOf("splice_region_variant")!=-1)return[Ps,"P",n];n++;if(t.indexOf("incomplete_terminal_codon_variant")!=-1)return[Ps,"N",n];n++;if(t.indexOf("stop_retained_variant")!=-1)return[Ps,"S",n];n++;if(t.indexOf("synonymous_variant")!=-1)return[Ps,"S",n];n++;if(t.indexOf("coding_sequence_variant")!=-1)return[Ps,ia,n];n++;if(t.indexOf("mature_mirna_variant")!=-1)return[Ps,"E",n];n++;if(t.indexOf("5_prime_utr_variant")!=-1)return[Ps,oa,n];n++;if(t.indexOf("3_prime_utr_variant")!=-1)return[Ps,ra,n];n++;if(t.indexOf("non_coding_transcript_exon_variant")!=-1)return[Ps,"E",n];n++;if(t.indexOf("intron_variant")!=-1)return[Ps,"Intron",n];n++;if(t.indexOf("nmd_transcript_variant")!=-1)return[Ps,"S",n];n++;if(t.indexOf("non_coding_transcript_variant")!=-1)return[Ps,"E",n];n++;if(t.indexOf("upstream_gene_variant")!=-1)return[Ps,sa,n];n++;if(t.indexOf("downstream_gene_variant")!=-1)return[Ps,sa,n];n++;if(t.indexOf("tfbs_ablation")!=-1)return[Ps,sa,n];n++;if(t.indexOf("tfbs_amplification")!=-1)return[Ps,sa,n];n++;if(t.indexOf("tf_binding_site_variant")!=-1)return[Ps,sa,n];n++;if(t.indexOf("regulatory_region_ablation")!=-1)return[Ps,sa,n];n++;if(t.indexOf("regulatory_region_amplification")!=-1)return[Ps,sa,n];n++;if(t.indexOf("feature_elongation")!=-1)return[Ps,sa,n];n++;if(t.indexOf("regulatory_region_variant")!=-1)return[Ps,sa,n];n++;if(t.indexOf("feature_truncation")!=-1)return[Ps,sa,n];n++;if(t.indexOf("intergenic_variant")!=-1)return[Ps,sa,n];n++;return[Ps,ia,n]};const wa='<circle cx="7" cy="12" r="7" fill="#b1b1b1"></circle><path d="M6.735557395310443e-16,-11A11,11 0 0,1 11,0L9,0A9,9 0 0,0 5.51091059616309e-16,-9Z" transform="translate(7,12)" fill="#858585" stroke="none"></path>';const _a={};const xa="S";_a[xa]={label:"Somatic",desc:"A variant found only in a tumor sample. The proportion is indicated by lack of any arc.",legend:'<circle cx="7" cy="12" r="7" fill="#b1b1b1"></circle>'};const ka="G";_a[ka]={label:"Germline",desc:"A constitutional variant found in a normal sample. The proportion is indicated by the span of the solid arc within the whole circle.",legend:wa};_a.germline=_a[ka];_a.somatic=_a[xa];const ja="R";_a[ja]={label:"Relapse",desc:"A somatic variant found only in a relapse sample. The proportion is indicated by the span of the hollow arc within the whole circle.",legend:'<circle cx="7" cy="12" r="7" fill="#b1b1b1"></circle><path d="M6.735557395310443e-16,-11A11,11 0 0,1 11,0L9,0A9,9 0 0,0 5.51091059616309e-16,-9Z" transform="translate(7,12)" fill="none" stroke="#858585"></path>'};const Na="GP";_a[Na]={label:"Germline pathogenic",desc:"A constitutional variant with pathogenic allele.",legend:wa};const Ca="GNP";_a[Ca]={label:"Germline non-pathogenic",desc:"A constitutional variant with non-pathogenic allele.",legend:wa,hidden:true};const Aa={usegm:"usegm",ds:"dataset",bigwig:"bigwig",bigwigstranded:"bigwigstranded",junction:"junction",mdsjunction:"mdsjunction",mdscnv:"mdscnv",mdssvcnv:"mdssvcnv",mdsexpressionrank:"mdsexpressionrank",mdsvcf:"mdsvcf",bedj:"bedj",pgv:"profilegenevalue",bampile:"bampile",hicstraw:"hicstraw",expressionrank:"expressionrank",aicheck:"aicheck",ase:"ase",mds2:"mds2",mds3:"mds3",bedgraphdot:"bedgraphdot",bam:"bam",ld:"ld"};function Sa(e){for(const t in Aa){if(e==Aa[t]){return true}}return false}const Ma={vcf:"vcf"};const Oa={vcf:"vcf",svcnvitd:"svcnvitd",geneexpression:"geneexpression"};const Ia={GCT:"A",GCC:"A",GCA:"A",GCG:"A",CGT:"R",CGC:"R",CGA:"R",CGG:"R",AGA:"R",AGG:"R",AAT:"N",AAC:"N",GAT:"D",GAC:"D",TGT:"C",TGC:"C",CAA:"Q",CAG:"Q",GAA:"E",GAG:"E",GGT:"G",GGC:"G",GGA:"G",GGG:"G",CAT:"H",CAC:"H",ATT:"I",ATC:"I",ATA:"I",TTA:"L",TTG:"L",CTT:"L",CTC:"L",CTA:"L",CTG:"L",AAA:"K",AAG:"K",ATG:"M",TTT:"F",TTC:"F",CCT:"P",CCC:"P",CCA:"P",CCG:"P",TCT:"S",TCC:"S",TCA:"S",TCG:"S",AGT:"S",AGC:"S",ACT:"T",ACC:"T",ACA:"T",ACG:"T",TGG:"W",TAT:"Y",TAC:"Y",GTT:"V",GTC:"V",GTA:"V",GTG:"V"};const Ea="*";function Ta(e){if(!e.genomicseq)return undefined;const t=[];if(e.coding){for(const[n,r]of e.coding.entries()){const n=e.genomicseq.substr(r[0]-e.start,r[1]-r[0]);if(e.strand=="-"){t.push(Ua(n))}else{t.push(n)}}}const n=t.join("");const r=[];const o=e.startCodonFrame?3-e.startCodonFrame:0;for(let e=o;e<n.length;e+=3){const t=Ia[n.substr(e,3)];r.push(t||Ea)}e.cdseq=n;return r.join("")}function La(e,t){if(e>=1e9)return(e/1e9).toFixed(1)+" Gb";if(e>=1e7)return Math.ceil(e/1e6)+" Mb";if(e>=1e6)return(e/1e6).toFixed(1)+" Mb";if(e>=1e4)return Math.ceil(e/1e3)+" Kb";if(e>=1e3)return(e/1e3).toFixed(1)+" Kb";return e+(t?"bytes":" bp")}const za={A:"#ca0020",T:"#f4a582",C:"#92c5de",G:"#0571b0"};function Ra(e){switch(e){case"A":return"T";case"T":return"A";case"C":return"G";case"G":return"C";case"a":return"t";case"t":return"a";case"c":return"g";case"g":return"c";default:return e}}function Ua(e){const t=[];for(let n=e.length-1;n>=0;n--){t.push(Ra(e[n]))}return t.join("")}function $a(e,t){const n={chr:e.chr,start:e.start,stop:e.stop,strand:e.strand,coding:[]};if(t.isskipexon||t.isaltexon){for(let r=0;r<e.exon.length;r++){const o=Math.max(e.codingstart,e.exon[r][0]);const i=Math.min(e.codingstop,e.exon[r][1]);if(o>i){continue}if(t.skippedexon.indexOf(r)==-1){n.coding.push([o,i])}}}else if(t.a5ss||t.a3ss){const 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t.categoryhidden){if(!t.categories[e])return"unknown hidden-by-default category "+e+" from set "+t.name}}else{t.categoryhidden={}}}else if(t.numericfilter){const e=[];for(const n of t.numericfilter){if(typeof n=="number"){e.push({side:"<",value:n})}else{e.push({side:n.side||"<",value:n.value})}}t.numericfilter=e}if(t.altalleleinfo){if(!t.altalleleinfo.key){return".key missing from .altalleleinfo from set "+t.name}}else if(t.locusinfo){if(!t.locusinfo.key){return".key missing from .locusinfo from set "+t.name}}else{return"neither .altalleleinfo or .locusinfo is available from set "+t.name}}}function qa(e,t){for(const n in e.majorchr){if(t.indexOf(n.replace("chr",""))!=-1){return true}}if(e.minorchr){for(const n in e.minorchr){if(t.indexOf(n.replace("chr",""))!=-1){return true}}}return false}function Da(e,t){let n=0,r=0;for(const o in e.majorchr){if(t.includes(o)){r++}else if(t.includes(o.replace("chr",""))){n++}}if(e.minorchr){for(const o in e.minorchr){if(t.includes(o)){r++}else if(t.includes(o.replace("chr",""))){n++}}}return[n,r]}function Ga(e,t){if(e.length==0)return t;e.sort(((e,t)=>e-t));const n=e[e.length-1];if(e.length<=5)return n;const r=e[Math.floor(e.length/4)];const o=e[Math.floor(e.length*3/4)];return Math.min(o+(o-r)*1.5,n)}function Ba(e,t){if(!e)return false;if(e.indexOf("/")!=-1){return e.split("/").indexOf(t)!=-1}return e.split("|").indexOf(t)!=-1}const Va={genomic:"genomic",splicingrna:"splicing RNA",exononly:"exon only",protein:"protein",gmsum:"aggregated exons"};function Ha(e,t){if(e.csq){let n;if(t.usegm){n=e.csq.find((e=>e._isoform==t.usegm.isoform))}if(!n){n=e.csq.find((e=>e.CANONICAL));if(!n){n=e.csq[0];for(const t of e.csq){if(t._csqrank<n._csqrank){n=t}}}}if(n){e.gene=n._gene;e.isoform=n._isoform;e.class=n._class;e.dt=n._dt;e.mname=n._mname;if(e.class==sa){delete e.class}}}else if(e.ann){let n=null;if(t.usegm){for(const r of 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Kc(e,t){t.append("a").text(e.name).attr("href","https://www.ncbi.nlm.nih.gov/snp/"+e.name).attr("target","_blank");t.append("div").attr("class","sja_tinylogo_body").text(e.observed);t.append("div").attr("class","sja_tinylogo_head").text("ALLELE")}function Qc(e,t){t.append("div").style("display","inline-block").style("background",e.bg).style("padding","3px").append("a").attr("href","https://www.ncbi.nlm.nih.gov/clinvar/variation/"+e.id).attr("target","_blank").style("color",e.textcolor).text(e.value).style("font-size",".9em").style("text-decoration","none")}function ef(e){const t=[];for(const n of e){let e=true;for(const r of t){if(n.chr==r.chr&&Math.max(n.start,r.start)<Math.min(n.stop,r.stop)){r.start=Math.min(r.start,n.start);r.stop=Math.max(r.stop,n.stop);e=false}}if(e){t.push({name:n.isoform,chr:n.chr,start:n.start,stop:n.stop})}}return t}function tf(e,t,n,r){const o=e.append("table").style("border-spacing","0px").style("border-collapse","separate").append("tr");const i=o.append("td").style("vertical-align","top").style("padding","10px 0px 10px 10px");const s=o.append("td").style("vertical-align","top").style("border-left","solid 1px #aaa").style("padding","10px");const a=t.findIndex((e=>e.active))==-1?false:true;if(r){i.append("div").style("padding","5px 10px").style("margin","5px 5px 10px 5px").style("font-weight","550").text(r)}for(let e=0;e<t.length;e++){const r=t[e];r.tab=i.append("div").style("padding","5px 10px").style("margin","0px").style("border-top","solid 1px #ddd").style("border-radius","0px").classed("sja_menuoption",!a&&e!=0).html(r.label);r.box=s.append("div").style("padding","3px").style("display",!a&&e==0||r.active?"block":"none");if(n&&r.callback||!a&&e==0&&r.callback||r.active){r.callback(r.box);delete 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yc},tkt:vc,gmmode:wc,domaincolorlst:_c,appear:xc,disappear:kc,tip:jc,sayerror:Nc,axisstyle:Cc,newpane:Ac,getdomaintypes:Sc,sketchSplicerna:Mc,sketchGmsum:Oc,sketchRna:Ic,sketchProtein2:Ec,sketchGene:Tc,sketchProtein:Lc,newpane3:zc,to_svg:Rc,filetypeselect:Uc,export_data:$c,flyindi:Fc,labelbox:Pc,category2legend:qc,bulk_badline:Dc,ensureisblock:Gc,mclasscolorchangeui:Bc,mclasscolor2table:Vc,bwSetting:Hc,tkexists:Jc,ranksays:Yc,rgb2hex:Xc,keyupEnter:Wc,may_findmatchingsnp:Zc,snp_printhtml:Kc,clinvar_printhtml:Qc,gmlst2loci:ef,tab2box:tf,tab_wait:nf});function of(e,t,n){var r,o,i,s,a;if(null==t)t=100;function l(){var c=Date.now()-s;if(c<t&&c>=0){r=setTimeout(l,t-c)}else{r=null;if(!n){a=e.apply(i,o);i=o=null}}}var c=function(){i=this;o=arguments;s=Date.now();var c=n&&!r;if(!r)r=setTimeout(l,t);if(c){a=e.apply(i,o);i=o=null}return a};c.clear=function(){if(r){clearTimeout(r);r=null}};c.flush=function(){if(r){a=e.apply(i,o);i=o=null;clearTimeout(r);r=null}};return c}of.debounce=of;var sf=of;function af(e){const t=e.div.append("input").attr("placeholder","Search gene").style("width",e.width||"100px");const n=e.resultdiv||(e.tip?e.tip.d:jc.d);function r(){if(e.resultdiv){e.resultdiv.selectAll("*").remove()}else if(e.tip){e.tip.hide()}else{jc.hide()}}t.on("keyup",(t=>{const o=t.target.value;if(o.length<=1){r();return}if(Wc(t)){const t=n.select(".sja_menuoption");if(t.size()>0){e.callback(t.text());r()}return}i()}));t.node().focus();function o(){Fl("genelookup",{genome:e.genome,input:t.property("value")}).then((o=>{if(o.error)throw o.error;if(!o.hits)throw".hits[] missing";if(e.resultdiv){e.resultdiv.selectAll("*").remove()}else if(e.tip){e.tip.clear().showunder(t.node())}else{jc.clear().showunder(t.node())}for(const t of o.hits){n.append("div").attr("class","sja_menuoption").text(t).on("click",(()=>{e.callback(t);r()}))}})).catch((e=>{n.append("div").text(e.message||e);if(e.stack)console.log(e.stack)}))}const i=sf.debounce(o,300)}function lf(e,t){return Vl("genelookup",{body:{deep:1,input:t,genome:e}}).then((e=>{if(e.error)throw e.error;if(!e.gmlst||e.gmlst.length==0)return null;return e.gmlst})).catch((e=>{throw e}))}function cf(e){if(!e){return null}const t={};for(const e in Ks){t[Ks[e].label.toUpperCase()]=e}return{genome:e,mclasslabel2key:t,data:{},sample2disease:{},patient2st:{},good:0,geneToUpper:true,snv:{loaded:false,header:null,badlines:[],missense:0,silent:0},svjson:{loaded:false,header:null,badlines:[]},fusion:{loaded:false,header:null,badlines:[],original:[]},sv:{loaded:false,header:null,badlines:[],original:[]},cnv:{loaded:false,header:null,badlines:[]},itd:{loaded:false,header:null,badlines:[]},del:{loaded:false,header:null,badlines:[]},truncation:{loaded:false,header:null,badlines:[]}}}function ff(e,t,n,r,o){let i=xa;if(e.sampletype){const t=e.sampletype.toLowerCase();switch(t){case"relapse":i=ja;break;case"germline":i=ka;break}if(e.sample){if(e.patient);else{e.patient=e.sample+" "+e.sampletype}}else{if(e.patient){e.sample=e.patient+" "+e.sampletype}}}else{if(e.patient){if(e.sample){e.sampletype=e.sample}else{e.sample=e.sampletype=e.patient}}else{if(e.sample){e.sampletype=e.sample}}}if(e.origin){const t=e.origin.toLowerCase();switch(t){case"r":case"relapse":i=ja;e.isrim2=true;break;case"g":case"germline":i=ka;e.isrim1=true;break;case"gp":case"germline pathogenic":i=Na;e.isrim1=true;break;case"gnp":case"germline nonpathogenic":case"germline non-pathogenic":i=Ca;e.isrim1=true;break;case"s":case"somatic":case"diagnosis":i=xa;break}}e.origin=i;if(!e.sample&&!e.patient){return}const s="no patient/individual name";if(e.patient){if(!t.patient2st[e.patient]){t.patient2st[e.patient]={}}t.patient2st[e.patient][e.sampletype]=e.sample}else{if(!t.patient2st[s]){t.patient2st[s]={}}t.patient2st[s][e.sampletype]=e.sample}if(e.sample){if(e.disease){if(e.sample in t.sample2disease){if(e.disease!=t.sample2disease[e.sample]){t.snv.badlines.push([n,'conflict of disease types for sample "'+e.sample+'": '+e.disease+", "+t.sample2disease[e.sample],r]);return true}}else{t.sample2disease[e.sample]=e.disease}}}return false}function df(e,t){const n=e.toLowerCase().split("\t");if(n.length<=1)return"invalid file header for snv/indel";const r=(...e)=>{for(const t of e){const e=n.indexOf(t);if(e!=-1)return e}return-1};let o=r("annovar_gene","annovar_sj_gene","gene","genename","gene_symbol","hugo_symbol");if(o==-1)return"gene missing from header";n[o]="gene";o=r("annovar_aachange","amino_acid_change","annovar_sj_aachange","aachange","protein_change","variant");if(o==-1)return"amino_acid_change missing from header";n[o]="mname";o=r("annovar_class","class","mclass","variant_class","variant_classification","annovar_sj_class");if(o==-1)return"variant_class missing from header";n[o]="class";o=r("chromosome","chr");if(o==-1)return"chromosome missing from header";n[o]="chr";o=r("wu_hg19_pos","start","start_position","chr_position","position");if(o==-1)return"start missing from header";n[o]="pos";o=r("annovar_isoform","mrna_accession","mrna accession","refseq_mrna_id","annovar_sj_filter_isoform","refseq","isoform");if(o==-1)return"isoform missing from header";n[o]="isoform";o=r("sample","sample_name","tumor_sample_barcode");if(o!=-1)n[o]="sample";o=r("patient","donor","target_case_id");if(o!=-1)n[o]="patient";o=r("quantitative_measurements");if(o!=-1)n[o]="qmset";o=r("mutant_reads_in_case","mutant_in_tumor","tumor_readcount_alt");if(o!=-1)n[o]="maf_tumor_v1";o=r("total_reads_in_case","total_in_tumor","tumor_readcount_total");if(o!=-1)n[o]="maf_tumor_v2";o=r("mutant_reads_in_control","mutant_in_normal","normal_readcount_alt");if(o!=-1)n[o]="maf_normal_v1";o=r("total_reads_in_control","total_in_normal","normal_readcount_total");if(o!=-1)n[o]="maf_normal_v2";o=r("cdna_change");if(o!=-1)n[o]="cdna_change";o=r("sampletype","sample type","sample_type");if(o!=-1)n[o]="sampletype";o=r("origin");if(o!=-1)n[o]="origin";o=r("cancer","disease","diagnosis");if(o!=-1)n[o]="disease";t.snv.header=n;t.snv.loaded=true;return false}function uf(e,t,n){if(t==""||t[0]=="#")return;const r=t.split("\t");const o={};for(let e=0;e<n.snv.header.length;e++){if(r[e]==undefined)break;o[n.snv.header[e]]=r[e]}if(!o.gene){n.snv.badlines.push([e,"missing gene",r]);return}if(o.gene.toUpperCase()=="UNKNOWN"){n.snv.badlines.push([e,"gene name is UNKNOWN",r]);return}if(!o.isoform){n.snv.badlines.push([e,"missing isoform",r]);return}if(!o.mname){o.mname=o.cdna_change;if(!o.mname){n.snv.badlines.push([e,"missing amino acid change",r]);return}}else{if(o.mname.indexOf("p.")==0){o.mname=o.mname.replace(/^p\./,"")}}if(!o.class){n.snv.badlines.push([e,"missing mutation class",r]);return}let i=n.mclasslabel2key[o.class.toUpperCase()];if(i){o.class=i}else{i=aa(o.class);if(i){o.class=i}else{n.snv.badlines.push([e,"wrong mutation class: "+o.class,r]);return}}if(ff(o,n,e,r,n.snv.badlines)){return}if(!o.chr){n.snv.badlines.push([e,"missing chromosome",r]);return}if(o.chr.toLowerCase().indexOf("chr")!=0){o.chr="chr"+o.chr}if(!o.pos){n.snv.badlines.push([e,"missing chromosome position",r]);return}const s=Number.parseInt(o.pos);if(Number.isNaN(s)){n.snv.badlines.push([e,"invalid chromosome position",r]);return}o.pos=s-1;if(o.maf_tumor_v2!=undefined&&o.maf_tumor_v1!=undefined){if(o.maf_tumor_v2=="");else{let t=Number.parseInt(o.maf_tumor_v1),i=Number.parseInt(o.maf_tumor_v2);if(Number.isNaN(t)||Number.isNaN(i)){n.snv.badlines.push([e,"invalid maf_tumor mutant and/or total read count",r]);return}o.maf_tumor={f:t/i,v1:t,v2:i}}delete o.maf_tumor_v1;delete o.maf_tumor_v2}if(o.maf_normal_v1!=undefined&&o.maf_normal_v2!=undefined){if(o.maf_normal_v2=="");else{let t=Number.parseInt(o.maf_normal_v1),i=Number.parseInt(o.maf_normal_v2);if(Number.isNaN(t)||Number.isNaN(i)){n.snv.badlines.push([e,"invalid maf_normal mutant and/or total read count",r]);return}o.maf_normal={f:t/i,v1:t,v2:i}}delete o.maf_normal_v1;delete o.maf_normal_v2}n.good++;if(o.class=="M"){n.snv.missense++}else if(o.class=="S"){n.snv.silent++}const a=n.geneToUpper?o.gene.toUpperCase():o.gene;if(!n.data[a]){n.data[a]=[]}o.dt=Ps;n.data[a].push(o)}function pf(e,t,n){const r=e.toLowerCase().split("\t");if(r.length<=1)return"invalid file header for fusions";const o=(...e)=>{for(const t of e){const e=r.indexOf(t);if(e!=-1)return e}return-1};let i=o("gene_a","gene1","genea");if(i==-1)return"gene_a missing from header";r[i]="gene1";i=o("gene_b","gene2","geneb");if(i==-1)return"gene_b missing from header";r[i]="gene2";i=o("chr_a","chr1","chra");if(i==-1)return"chr_a missing from header";r[i]="chr1";i=o("chr_b","chr2","chrb");if(i==-1)return"chr_b missing from header";r[i]="chr2";i=o("pos_a","position_a","position1","posa");if(i==-1)return"pos_a missing from header";r[i]="position1";i=o("pos_b","position_b","position2","posb");if(i==-1)return"pos_b missing from header";r[i]="position2";i=o("isoform_a","refseq_a","refseq1","isoform1","sv_refseqa");if(i==-1)return"isoform_a missing from header";r[i]="isoform1";i=o("isoform_b","refseq_b","refseq2","isoform2","sv_refseqb");if(i==-1)return"isoform_b missing from header";r[i]="isoform2";i=o("strand_a","orta");if(i==-1)return"strand_a missing from header";r[i]="strand1";i=o("strand_b","ortb");if(i==-1)return"strand_b missing from header";r[i]="strand2";i=o("sample","sample_name","tumor_sample_barcode");if(i!=-1)r[i]="sample";i=o("patient","donor","target_case_id");if(i!=-1)r[i]="patient";i=o("sampletype","sample type","sample_type");if(i!=-1)r[i]="sampletype";i=o("disease");if(i!=-1)r[i]="disease";i=o("origin");if(i!=-1)r[i]="origin";if(n){t.sv.loaded=true;t.sv.header=r}else{t.fusion.loaded=true;t.fusion.header=r}return false}function hf(e,t,n,r){if(t==""||t[0]=="#")return;const o=t.split("\t");const i={};const s=r?n.sv.header:n.fusion.header;const a=r?n.sv.badlines:n.fusion.badlines;for(let e=0;e<s.length;e++){i[s[e]]=o[e]}if(!i.chr1){a.push([e,"missing chr1",o]);return}if(i.chr1.toLowerCase().indexOf("chr")!=0){i.chr1="chr"+i.chr1}if(!i.chr2){a.push([e,"missing chr2",o]);return}if(i.chr2.toLowerCase().indexOf("chr")!=0){i.chr2="chr"+i.chr2}let l=i.position1;if(!l){a.push([e,"missing position1",o]);return}let c=Number.parseInt(l);if(Number.isNaN(c)||c<=0){a.push([e,"invalid value for position1",o]);return}i.position1=c;l=i.position2;if(!l){a.push([e,"missing position2",o]);return}c=Number.parseInt(l);if(Number.isNaN(c)||c<=0){a.push([e,"invalid value for position2",o]);return}i.position2=c;if(ff(i,n,e,o)){return}if(i.isoform1&&i.isoform1.indexOf(",")!=-1){const e=i.isoform1.split(",");i.isoform1=undefined;for(const t of e){if(t!="")i.isoform1=t}}if(i.isoform2&&i.isoform2.indexOf(",")!=-1){const e=i.isoform2.split(",");i.isoform2=undefined;for(const t of e){if(t!="")i.isoform2=t}}if(!i.gene1){i.isoform1=undefined}if(!i.gene2){i.isoform2=undefined}if(i.gene1){n.good++;const e={dt:r?Bs:qs,class:r?ca:la,isoform:i.isoform1,mname:i.gene2||i.chr2,sample:i.sample,patient:i.patient,sampletype:i.sampletype,origin:i.origin,disease:i.disease,pairlst:[{a:{name:i.gene1,isoform:i.isoform1,strand:i.strand1,chr:i.chr1,position:i.position1},b:{name:i.gene2,isoform:i.isoform2,strand:i.strand2,chr:i.chr2,position:i.position2}}]};const t=n.geneToUpper?i.gene1.toUpperCase():i.gene1;if(!n.data[t]){n.data[t]=[]}n.data[t].push(e)}if(i.gene2&&i.gene2!=i.gene1){n.good++;const e={dt:r?Bs:qs,class:r?ca:la,isoform:i.isoform2,mname:i.gene1||i.chr1,sample:i.sample,patient:i.patient,sampletype:i.sampletype,origin:i.origin,disease:i.disease,pairlst:[{a:{name:i.gene1,isoform:i.isoform1,strand:i.strand1,chr:i.chr1,position:i.position1},b:{name:i.gene2,isoform:i.isoform2,strand:i.strand2,chr:i.chr2,position:i.position2}}]};const t=n.geneToUpper?i.gene2.toUpperCase():i.gene2;if(!n.data[t]){n.data[t]=[]}n.data[t].push(e)}}function mf(e){const t={};for(const n in e){if(n=="pairlst")continue;const r=e[n];const o=typeof r;if(o=="object"){continue}t[n]=r}if(e.pairlst){t.pairlst=[];for(const n of e.pairlst){const e={};for(const t in n){if(t=="a"||t=="b"||t=="interstitial"){continue}e[t]=n[t]}if(n.a){e.a={};for(const t in n.a){const r=n.a[t];if(typeof r=="object"){continue}e.a[t]=r}}if(n.b){e.b={};for(const t in n.b){const r=n.b[t];if(typeof r=="object"){continue}e.b[t]=r}}if(n.interstitial){e.interstitial={};for(const t in n.interstitial){const r=n.interstitial[t];if(typeof r=="object"){continue}e.interstitial[t]=r}}t.pairlst.push(e)}}return t}function gf(e,t){const n=e.toLowerCase().split("\t");if(n.length<=1)return"invalid file header for svjson";const r=(...e)=>{for(const t of e){const e=n.indexOf(t);if(e!=-1)return e}return-1};let o=r("sample");if(o!=-1)n[o]="sample";o=r("sampletype");if(o!=-1)n[o]="sampletype";o=r("patient");if(o!=-1)n[o]="patient";o=r("json","jsontext");if(o==-1)return["json missing from 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n.data)){n.data[s]=[]}n.data[s].push(o)}function _f(e,t){const n=e.toLowerCase().split("\t");if(n.length<=1)return"invalid header line for ITD";const r=(...e)=>{for(const t of e){const e=n.indexOf(t);if(e!=-1)return e}return-1};let o=r("gene");if(o==-1)return"gene missing from header";n[o]="gene";o=r("annovar_isoform","mrna_accession","mrna accession","refseq_mrna_id","annovar_sj_filter_isoform","refseq","isoform");if(o==-1)return"isoform missing from header";n[o]="isoform";o=r("rnaposition");if(o!=-1){n[o]="rnaposition";o=r("rnaduplength");if(o==-1)return"rnaduplength is required when rnaposition is present";n[o]="rnaduplength"}o=r("chromosome","chr");if(o!=-1){n[o]="chr";o=r("chr_start");if(o==-1)return"chr_start is required when chr is present";n[o]="chrpos1";o=r("chr_stop");if(o==-1)return"chr_stop is required when chr is 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t=Number.parseInt(o.chrpos1);if(Number.isNaN(t)||t<0){n.itd.badlines.push([e,"invalid chr_start value",r]);return}o.chrpos1=t;t=Number.parseInt(o.chrpos2);if(Number.isNaN(t)||t<0){n.itd.badlines.push([e,"invalid chr_stop value",r]);return}o.chrpos2=t}if(ff(o,n,e,r,n.itd.badlines)){return}o.dt=Vs;o.class=Qs;o.mname="ITD";n.good++;var i=n.geneToUpper?o.gene.toUpperCase():o.gene;if(!(i in n.data)){n.data[i]=[]}n.data[i].push(o)}function kf(e,t){const n=e.toLowerCase().split("\t");if(n.length<=1)return"invalid header line for intragenic deletion";const r=(...e)=>{for(const t of e){const e=n.indexOf(t);if(e!=-1)return e}return-1};let o=r("gene");if(o==-1)return"gene missing from header";n[o]="gene";o=r("annovar_isoform","mrna_accession","mrna accession","refseq_mrna_id","annovar_sj_filter_isoform","refseq","isoform");if(o==-1)return"isoform missing from header";n[o]="isoform";o=r("rnaposition");if(o!=-1){n[o]="rnaposition";o=r("rnadellength");if(o==-1)return"rnadellength is required when 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r=e.browserview.assays[n];if(r.combined&&r.combinetk){t.push(r.combinetk)}}}if(!e.genome.tkset){e.genome.tkset=[]}const n={name:e.name,tklst:t};if(e.trackfacets){if(!Array.isArray(e.trackfacets)){return".trackfacets is not an array"}const t=[];for(const n of e.trackfacets){if(!n.samples){return"trackfacets: .samples missing from facet "+n.name}if(!Array.isArray(n.samples)){return"trackfacets: .samples is not array from facet "+n.name}if(!n.assays){return"trackfacets: .assays missing from a facet "+n.name}if(!Array.isArray(n.assays)){return"trackfacets: .assays is not array from a facet "+n.name}t.push(n)}if(t.length){n.facetlst=t}}e.genome.tkset.push(n);return null}function Wf(e){if(e.browserview.position){let t;if(typeof e.browserview.position=="string"){t=Pf(e.browserview.position,e.genome);if(!t){return".browserview.position invalid value"}}else{t=e.browserview.position}const n=Ff(e.genome,t.chr,t.start,t.stop);if(n){return".browserview.position error: 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g(){m=!m;d.style("display",m==true?"inline-block":"none");u.style("display",m==true?"none":"inline-block");h.style("display",m==true?"block":"none")}return{header_row:a,header:p,body:h,app_div:i,id:s}}function sd(e,t,n,r,o,i){let s,a,l,c,f,d;if(o!==undefined)[a,l,c,f,d]=td(o,n);else{[s,a,l,c,f,d]=zc(e,t,n);s.header.text("Load mutation from text files")}a.append("div").style("margin","20px 0px").style("color","#858585").html(`\n\t<p>Choose one file and upload to initiate the display panel.<br>From there you can add additional files.</p>\n\t<div>Supported data types:</div>\n\t<ul>\n\t  <li>SNV and indel</li>\n\t  <ul>\n\t    <li><a href=https://drive.google.com/open?id=1OJ9aXq2_-a3BfIQdKLYCYzrJRTpu4_9i3gephTY-Z38 target=_blank>Format</a>,\n\t        <a href=https://proteinpaint.stjude.org/ppdemo/hg19/heatmap/exampleFiles/example.snvindel.txt target=_blank>example file</a></li>\n\t  </ul>\n\t  <li>SV or fusion transcript</li>\n\t  <ul>\n\t    <li><a href=https://drive.google.com/open?id=1klDZ0MHVkQTW2-lCu_AvpRE4_FcbhdB-yI17wNdPaOM target=_blank>Tabular format</a>,\n\t        <a href=https://proteinpaint.stjude.org/ppdemo/hg19/heatmap/exampleFiles/example.svfusion.txt target=_blank>example file</a>\n\t\t</li>\n\t\t<li>JSON-format, to come</li>\n\t  </ul>\n\t  <li>CNV, gene-level</li>\n\t  <ul>\n\t    <li><a href=https://drive.google.com/open?id=1WHptqOWNf96V0bYEDpj-EsKZGYnbBNc9aQIrhzdEJaU target=_blank>Format</a>, \n\t        <a href=https://proteinpaint.stjude.org/ppdemo/hg19/heatmap/exampleFiles/example.cnv.txt target=_blank>example file</a>\n\t\t</li>\n\t  </ul>\n\t  <li>ITD</li>\n\t  <ul>\n\t  \t<li>Internal tandem duplication, in-frame</li>\n\t    <li><a href=https://drive.google.com/open?id=1Bh9awBsraoHbV8iWXv_3oDeXMsjIAHaOKHr973IJyZc target=_blank>Format</a>, \n\t        <a href=https://proteinpaint.stjude.org/ppdemo/hg19/heatmap/exampleFiles/example.itd.txt target=_blank>example file</a>\n\t\t</li>\n\t  </ul>\n\t  <li>Intragenic deletion, in-frame</li>\n\t  <ul>\n\t    <li><a href=https://drive.google.com/open?id=1tWbf3rg3BmVIZPGGPk023P0aBkDw_ry5XuZLGyGodyg target=_blank>Format</a>, \n\t        <a href=https://proteinpaint.stjude.org/ppdemo/hg19/heatmap/exampleFiles/example.deletion.txt target=_blank>example file</a>\n\t\t</li>\n\t  </ul>\n\t  <li>Truncation</li>\n\t  <ul>\n\t  \t<li>Either N-terminus loss or C-terminus loss</li>\n\t    <li><a href=https://drive.google.com/open?id=1P1g-Y8r30pSKfan1BhYZcsUtSk7wRb4plaO1S-JCJr4 target=_blank>Format</a>, \n\t        <a href=https://proteinpaint.stjude.org/ppdemo/hg19/heatmap/exampleFiles/example.truncation.txt target=_blank>example file</a>\n\t\t</li>\n\t  </ul>\n\t</ul>`);const u=()=>{c.selectAll("*").remove();new Of({bulkin:ld,genomes:n,gselect:l,content2flag:ad,flag2tp:h,filediv:c,init_bulk_flag:cf});c.append("span").html("Select data type&nbsp;");const e=Uc(c).style("margin-right","20px");const t=c.append("input").attr("type","file").on("change",(t=>{const r=cf(n[l.options[l.selectedIndex].innerHTML]);r.geneToUpper=p.property("checked");f.text("");const o=t.target.files[0];if(!o){u();return}if(o.size==0){f.text("Wrong file: "+o.name);u();return}const i=new FileReader;i.onload=t=>{const n=ad(t.target.result,e.node().selectedIndex,r);if(n){f.text("Error: "+n);u();return}h(r,o)};i.onerror=function(){f.text("Error reading file "+o.name);u();return};f.text("Parsing file "+o.name+" ...");i.readAsText(o,"utf8")}));setTimeout((()=>t.node().focus()),1100)};u();c.append("span").html("<br/>Convert gene name to uppercase &nbsp;");const p=c.append("span").append("input").attr("type","checkbox").property("checked",true);function h(e,t,n=null,i=null){if(typeof e=="string"){f.text(e);u();return}f.text("");u();const l=n?n:Object.assign({genome:e.genome,name:t.name});const c=ld({flag:e,filename:t.name,cohort:l,flag2thisds:i});if(c){f.text("Error with "+t.name+": "+c);return}if(e.good==0){f.text("No mutations can be loaded");return}let p;if(s){kc(s.pane);const e=Ac({x:100,y:100,toshrink:true});e.header.html('<span style="opacity:.5">FILE</span> '+t.name);p=e.body}if(o!==undefined){p=d.append("div").html('<span style="opacity:.5">FILE</span> '+t.name)}a.selectAll("*").remove();import("./tp.ui-f01b186b.js").then((function(e){return e.t})).then((e=>{e.default(l,p,r)}));return l}return function e(t,n){const r=ad(t.content,n,flag);if(r){f.text("Error: "+r);u();return}h(flag,t)}}function ad(e,t,n){if(!n)return"should not happen!";let r;switch(t){case 0:r=fd(e,n);if(r)return r;break;case 1:r=gd(e,n,true);if(r)return r;break;case 2:r=gd(e,n,false);if(r)return r;break;case 3:r=pd(e,n);if(r)return r;break;case 4:r=hd(e,n);if(r)return r;break;case 5:r=md(e,n);if(r)return r;break;case 6:r=ud(e,n);if(r)return r;break;default:return"unknown option array index from file type <select>: "+t}}function ld(e,t=null){const n=e.flag;const r=e.cohort;if(!r.p2st){r.p2st={}}if(!r.dsset){r.dsset={}}if(!r.assaylst){r.assaylst=[]}if(n.variantgene){if(r.variantgene){return"variantgene already set for this cohort"}r.variantgene=n.variantgene}if(n.snv.badlines.length>0){Dc(n.snv.header,n.snv.badlines)}if(n.fusion.badlines.length>0){Dc(n.fusion.header,n.fusion.badlines)}if(n.sv.badlines.length>0){Dc(n.sv.header,n.sv.badlines)}if(n.cnv.badlines.length>0){Dc(n.cnv.header,n.cnv.badlines)}if(n.itd.badlines.length>0){Dc(n.itd.header,n.itd.badlines)}if(n.del.badlines.length>0){Dc(n.del.header,n.del.badlines)}if(n.truncation.badlines.length>0){Dc(n.truncation.header,n.truncation.badlines)}if(n.good==0){return false}const o={};let i=false;if(n.snv.loaded){for(const e of n.snv.header){o[e]=1}if("maf_tumor_v1"in o&&"maf_tumor_v2"in o){i=true}}if(n.cnv.loaded){for(const e of n.cnv.header){o[e]=1}}if(n.fusion.loaded){for(const e of n.fusion.header){o[e]=1}}if(n.sv.loaded){for(const e of n.sv.header){o[e]=1}}if(n.itd.loaded){for(const e of n.itd.header){o[e]=1}}if(n.del.loaded){for(const e of n.del.header){o[e]=1}}if(n.truncation.loaded){for(const e of n.truncation.header){o[e]=1}}const s="sample"in o||"patient"in o;const a="disease"in o;const l="sampletype"in o;let c;if(e.flag2thisds){c=e.flag2thisds;if(s&&!c.hassample){return'"sample" column found in new data but not in existing data'}if(!s&&c.hassample){return'"sample" column found in existing data but not in new data'}if(a&&!c.hasdisease){return'"disease" column found in new data but not in existing data'}if(!a&&c.hasdisease){return'"disease" column found in existing data but not in new data'}if(l&&!c.hasst){return'"sampletype" column found in new data but not in existing data'}if(!l&&c.hasst){return'"sampletype" column found in existing data but not in new data'}for(const e in n.data){const t=c.bulkdata[e];if(t){c.bulkdata[e]=t.concat(n.data[e])}else{c.bulkdata[e]=n.data[e]}}}else{let t=e.filename+(n.tpsetname?"_"+n.tpsetname:"");if(t in n.genome.datasets){let e=1;let r=t+" "+e;while(r in n.genome.datasets){e++;r=t+" "+e}t=r}c={label:t,bulkdata:n.data,hassample:s,hasdisease:a,hastumormaf:i,hasst:l,genome:r.genome,import:{},imported:{},importsilent:n.snv.silent==0?false:n.snv.missense/n.snv.silent>=5?false:true};n.genome.datasets[t]=c;r.dsset[t]=c;if(r.dbexpression){if(r.dbexpression.tidy){try{r.dbexpression.tidy=new Function(...r.dbexpression.tidy)}catch(e){err("invalid JavaScript for dbexpression.tidy");delete r.dbexpression}}c.dbexpression=r.dbexpression}if(a){c.stratify=[{label:"disease",attr1:{k:"disease",label:"disease"}}]}}if(s){for(const e in n.data){for(const t of n.data[e]){let e=t.patient;if(!e){e=t.sample;if(!e){continue}}if(!r.p2st[e]){r.p2st[e]={}}let n=t.sampletype;if(!n){n=e}if(!r.p2st[e][n]){r.p2st[e][n]={dsset:{},tktemplate:[]}}if(!r.p2st[e][n].dsset[c.label]){r.p2st[e][n].dsset[c.label]=[]}r.p2st[e][n].dsset[c.label].push(t)}}}if(t)t();return false}function cd(e){if(!e.name)e.name="Unnamed dataset";let t=e.holder;if(!t){const e=Ac({x:100,y:100});t=e.body}const n=t.append("div");new Promise(((t,n)=>{const r={dsset:{}};for(const t in e){if(t=="snvindel"||t=="svjson"||t=="cnv"||t=="sv"||t=="mutationset"){continue}r[t]=e[t]}t(r)})).then((t=>{if(!e.snvindel&&!e.svjson&&!e.cnv&&!e.sv)return t;const n=cf(t.genome);if(e.snvindel){const t=fd(e.snvindel,n);if(t)throw{message:"error in snvindel data: "+t};delete e.snvindel}if(e.svjson){const t=dd(e.svjson,n);if(t)throw{message:"error in svjson data: "+t};delete e.svjson}if(e.sv){const t=gd(e.sv,n);if(t)throw{message:"error in svjson data: "+t};delete e.sv}if(e.cnv){const t=ud(e.cnv,n);if(t)throw{message:"error in cnv data: "+t};delete e.cnv}const r=ld({flag:n,filename:e.name,cohort:t});if(r)throw{message:"Error parsing data: "+r};return t})).then((t=>{if(!e.mutationset)return t;if(!Array.isArray(e.mutationset))throw{message:"mutationset is not an array"};const n=[];for(const r of e.mutationset){const o=cf(t.genome);const 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n=e.split(/\r?\n/);let r=n[0];let o=0;while(r[0]=="#"){o++;r=n[o]}if(!r)return"no header line";const i=_f(r,t);if(i)return"header error: "+i;for(let e=o+1;e<n.length;e++){if(n[e]=="")continue;if(n[e][0]=="#")continue;xf(e,n[e],t)}}function hd(e,t){const n=e.split(/\r?\n/);let r=n[0];let o=0;while(r[0]=="#"){o++;r=n[o]}if(!r)return"no header line";const i=kf(r,t);if(i)return"header error: "+i;for(let e=o+1;e<n.length;e++){if(n[e]=="")continue;if(n[e][0]=="#")continue;jf(e,n[e],t)}}function md(e,t){const n=e.split(/\r?\n/);let r=n[0];let o=0;while(r[0]=="#"){o++;r=n[o]}if(!r)return"no header line";const i=Nf(r,t);if(i)return"header error: "+i;for(let e=o+1;e<n.length;e++){if(n[e]=="")continue;if(n[e][0]=="#")continue;Cf(e,n[e],t)}}function gd(e,t,n){const r=e.split(/\r?\n/);let o=r[0];let i=0;while(o[0]=="#"){i++;o=r[i]}if(!o)return"no header line";const s=pf(o,t,n);if(s)return"header error: "+s;for(let e=i+1;e<r.length;e++){if(r[e]=="")continue;if(r[e][0]=="#")continue;hf(e,r[e],t,n)}}function bd(e,t){e.style("opacity",0).style("display",t||"block").transition().style("opacity",1)}function yd(e,t){e.style("opacity",1).transition().style("opacity",0).call((()=>{if(t){e.remove()}else{e.style("display","none").style("opacity",1)}}))}function vd(e,t){let n;if(typeof t=="string"){n=t}else{n=t.message||t.error;if(t.stack)console.log(t.stack)}const r=e.append("div").attr("class","sja_errorbar");r.append("div").text(n);r.append("div").html("&#10005;").on("click",(()=>{yd(r,true)}))}function wd(e){try{throw new Error}catch(t){const n=t.stack.split("\n");const r=n[2].trim();const o=/\s*at\s+(.*)\s+\((.*).proteinpaint.js:(\d+):(\d+)\)/;const i=r.match(o);if(i){const t=i[1];const n=i[2].replace(/^.*\/bin\//,"").replace(/_([^_]+)$/,".$1").replaceAll(/_/g,"/");const r=`${e} [${n} ${t}()]`;throw new Error(r)}else{throw new Error(e)}}}function _d(e,t){if(typeof e=="string")return vd(t,e);if(e.length===0)return;if(e.length===1)return vd(t,e[0]);let n=false;const r=t.append("div").attr("class","sja_errorbar").on("click",(()=>{n=!n;i.style("display",n?"block":"none")}));const o=r.append("div").style("display","inline-block");o.append("div").style("display","inline-block").style("color","white").style("background-color","red").style("border-radius","100px").style("padding","1px 4px").text(e.length);o.append("div").text("errors found.").style("padding","3px").style("display","inline-block");r.append("div").style("display","inline-block").style("float","right").html("&#10005;").on("click",(()=>{yd(r,true)}));const i=r.append("div").style("display","none").style("margin-left","10px");for(const t of e){i.append("div").text(t)}}async function xd(e,t){const n=await Vl("snp",{method:"POST",body:JSON.stringify({byName:true,genome:e.name,lst:[t]})});if(n.error)throw n.error;if(!n.results||n.results.length==0)throw t+": not a SNP";for(const t of n.results){const n=e.chrlookup[t.chrom.toUpperCase()];if(n&&n.major){return{chr:t.chrom,start:t.chromStart,stop:t.chromEnd}}}const r=n.results[0];return{chr:r.chrom,start:r.chromStart,stop:r.chromEnd}}async function kd(e){if(!e.holder)throw"No holder for block.init";if(!e.genome)throw"no genome";if(e.holder instanceof Element)e.holder=ot(e.holder);if(!e.tklst)e.tklst=[];if(e.query){await jd(e);return}if(e.model&&e.allmodels){await Nd(e);return}}async function jd(e){const t=e.holder.append("p").style("font-size","2em").style("color","#858585").text("Searching for "+e.query+" ...");const n=await Vl("genelookup",{body:{deep:1,input:e.query,genome:e.genome.name}});if(!n)throw"querying genes: server error";if(n.error)throw"error querying genes: "+n.error;if(!n.gmlst||n.gmlst.length==0){if(e.genome.hasSNP){try{const n=await xd(e.genome,e.query);t.remove();const r={genome:e.genome,holder:e.holder,chr:n.chr,start:Math.max(0,n.start-300),stop:n.start+300,nobox:true,tklst:e.tklst,debugmode:e.debugmode};ic(e.genome,r.tklst);const o=await import("./block-2f22e7fd.js").then((function(e){return e.c}));const i=new o.Block(r);i.addhlregion(n.chr,n.start,n.stop-1)}catch(n){t.text("Not a gene or SNP: "+e.query)}}else{t.text("No match to gene: "+e.query)}return}t.remove();e.allmodels=n.gmlst;for(const t of e.allmodels){if(t.isoform.toUpperCase()==(n.found_isoform?n.found_isoform.toUpperCase():e.query.toUpperCase())){e.model=t;await Nd(e);return}}const r=[];for(const t of e.allmodels){if(!t.isoform)throw"isoform missing from one gene model: "+JSON.stringify(t);const n=t.isoform.toUpperCase();if(e.genome.isoformcache.has(n)){let r=true;for(const o of e.genome.isoformcache.get(n)){if(o.chr==t.chr&&o.start==t.start&&o.stop==t.stop&&o.strand==t.strand){r=false;break}}if(r){e.genome.isoformcache.get(n).push(t)}}else{e.genome.isoformcache.set(n,[t])}if(t.isoform.toUpperCase()==e.query.toUpperCase()){r.push(t);break}if(t.isdefault){r.push(t)}}if(r.length==1){e.model=r[0]}else if(r.length>1){for(const t of r){if(t.chr=="chrY"){continue}const n=e.genome.chrlookup[t.chr.toUpperCase()];if(!n){continue}if(!n.major){continue}e.model=t;break}if(!e.model){e.model=r[0]}}if(!e.model){e.model=e.allmodels[0]}await Nd(e)}async function Nd(e){if(e.model.genomicseq){r();Cd(e);return}const t={genome:e.genome.name,coord:e.model.chr+":"+(e.model.start+1)+"-"+e.model.stop};const n=await Vl("ntseq",{method:"POST",body:JSON.stringify(t)});if(!n)throw"getting sequence: server error";if(n.error)throw"getting sequence: "+n.error;if(!n.seq)throw"no nt seq???";e.model.genomicseq=n.seq.toUpperCase();e.model.aaseq=Ta(e.model);r();await Cd(e);function r(){if(e.model.aaseq){const t=e.model.aaseq.indexOf(Ea);const n=e.model.cdslen-(e.model.startCodonFrame?3-e.model.startCodonFrame:0);if(t!=-1&&t<n/3-1){vd(e.holder,"Translating "+e.model.isoform+" ends at "+t+" AA, expecting "+n/3)}}}}async function Cd(e){const t=new Map;for(const n of e.allmodels){if(!n.pdomains){n.pdomains=[];n.domain_hidden={};if(!t.has(n.isoform))t.set(n.isoform,[]);t.get(n.isoform).push(n)}}if(t.size==0){await Ad(e);return}const n=await Vl("pdomain",{method:"POST",body:JSON.stringify({genome:e.genome.name,isoforms:[...t.keys()]})});if(n.error)throw"error getting protein domain: "+n.error;if(n.lst){const e=St().range(_c);for(const r of n.lst){for(const e of t.get(r.name)){e.pdomains=r.pdomains}for(const t of r.pdomains){if(!t.color){t.color=e(t.name+t.description)}}}}await Ad(e)}async function Ad(e){let t=e.gmmode;if(!t){if(e.model.cdslen){t=wc.protein}else{t=wc.exononly}}if(e.dataset){if(!Array.isArray(e.dataset))throw"dataset is not array";for(const t of e.dataset){if(e.genome.datasets[t]&&!e.genome.datasets[t].legacyDsIsUninitiated)continue;const n=await Vl(`getDataset?genome=${e.genome.name}&dsname=${t}`);if(n.error)throw`invalid name from dataset[]: ${n.error}`;if(!n.ds)throw".ds missing";const r=e.genome.datasets[n.ds.label];Object.assign(r,n.ds);const o=await import("./legacyDataset-354f1a29.js");o.validate_oldds(r);delete r.legacyDsIsUninitiated}}const n=await import("./block-2f22e7fd.js").then((function(e){return e.c}));e.__blockInstance=new n.Block({genome:e.genome,holder:e.holder,nobox:true,usegm:e.model,gmstackheight:37,allgm:e.allmodels,datasetlst:e.dataset,legacyDsFilter:e.legacyDsFilter,mset:e.mset,hlaachange:e.hlaachange,hlvariants:e.hlvariants,hlregions:e.hlregions,gmmode:t,hidedatasetexpression:e.hidedatasetexpression,hidegenecontrol:e.hidegenecontrol,hidegenelegend:e.hidegenelegend,variantPageCall_snv:e.variantPageCall_snv,datasetqueries:e.datasetqueries,samplecart:e.samplecart,debugmode:e.debugmode,tklst:e.tklst,mclassOverride:e.mclassOverride,hide_dsHandles:e.hide_dsHandles,onloadalltk_always:e.onloadalltk_always})}var Sd=Object.freeze({__proto__:null,default:kd});async function Md(e,t){let n=[],r=[];if(e&&e.includes(","))n=e.split(",");else if(e)n.push(e);else if(t&&t.includes(","))r=t.split(",");else if(t)r.push(t);const o=[];if(n.length){const e=undefined;for(const t of n){o.push(await Od(t,e))}}else if(r.length){const e=undefined;for(const t of r){o.push(await Od(e,t))}}return o}async function Od(e,t){const n=await Id(e,t);Ed(n);const r=Td(n);return r}async function Id(e,t){if(e!==undefined&&e=="")throw".jsonfile missing";if(t!==undefined&&t=="")throw".jsonurl missing";let n;if(e!==undefined)n=await Fl("textfile",{file:e});else if(t!==undefined)n=await Fl("urltextfile",{url:t});if(n.error){throw n.error}return JSON.parse(n.text)}function Ed(e){if(!e)throw"file is missing";if(!e.type)throw"dataset type is missing";const t=e.svcnvfile||e.svcnvurl;const n=e.vcffile||e.vcfurl;if(!t&&!n)throw"vcf or cnv file/url is required";if(Object.keys(e).filter((e=>e.includes("expression"))).length){if(!e.expressionfile&&!e.expressionurl)throw"expression file/url is missing"}if(Object.keys(e).filter((e=>e.includes("rnabam"))).length){if(!e.rnabamfile&&!e.rnabamurl)throw"rnabam file/url is missing"}if(e.sampleset){for(const t of e.sampleset){if(e.sampleset.length!=1&&!t.name)throw"sampleset name is missing";if(!t.samples)throw"sampleset samples[] is missing"}}if(e.sample2assaytrack){for(const[t,n]of 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if(e.svcnvurl)t.url=e.svcnvurl;if(Object.keys(e).filter((e=>e.includes("expression"))).length){t.checkexpressionrank={file:e.expressionfile,url:e.expressionurl}}if(Object.keys(e).filter((e=>e.includes("vcf"))).length){t.checkvcf={file:e.vcffile,url:e.vcfurl}}if(e.vcf){if(e.vcf.hiddenclass){t.vcf=[];t.vcf.hiddenclass=e.vcf.hiddenclass}}if(Object.keys(e).filter((e=>e.includes("rnabam"))).length){t.checkrnabam={file:e.rnabamfile,url:e.rnabamurl}}if(e.sampleset){t.sampleset=e.sampleset}if(e.sample2assaytrack){t.sample2assaytrack=e.sample2assaytrack}if(e.groupsamplebyattr){t.groupsamplebyattr=e.groupsamplebyattr}t.fixedgeneexpression=e.fixedgeneexpression;t.getallsamples=e.getallsamples;t.valueCutoff=e.cnvValueCutoff!==undefined?e.cnvValueCutoff:undefined;t.bplengthUpperLimit=e.cnvLengthUpperLimit!==undefined?e.cnvLengthUpperLimit:undefined;t.segmeanValueCutoff=e.segmeanValueCutoff!==undefined?e.segmeanValueCutoff:undefined;t.lohLengthUpperLimit=e.lohLengthUpperLimit!==undefined?e.lohLengthUpperLimit:undefined;t.multihidelabel_vcf=e.multihidelabel_vcf!==undefined?e.multihidelabel_vcf:undefined;t.multihidelabel_fusion=e.multihidelabel_fusion!==undefined?e.multihidelabel_fusion:undefined;t.multihidelabel_sv=e.multihidelabel_sv!==undefined?e.multihidelabel_sv:undefined;t.legend_vorigin=e.legend_vorigin;return t}async function Ld(e,t){let n={};const r=await Id(e,t);n.mdssamplescatterplot=r;return n}function zd(e){return Number.isFinite(e)||!isNaN(parseFloat(e))}function Rd(e,t,n,r,o){if(r>=1){const t=Math.floor(e*r);if(o)return`${t}${n.charAt(0)}`;return`${t} ${t>1?n+"s":""}`}const i=Math.floor(e*r);const s=Math.ceil(e%(1/r));if(s==0){if(o)return`${i}${n.charAt(0)}`;return`${i} ${i>1?n+"s":""}`}if(o)return`${i}${n.charAt(0)}${s}${t.charAt(0)}`;return`${i} ${i>1?n+"s":n} ${s} ${s>1?t+"s":t}`}function Ud(e="",t=console.warn){const n=e?{search:e}:window.location;const r=new Map;for(const e of n.search.substr(1).split("&")){if(!e)continue;const n=e.split("=");if(n.length==2&&n[0]!=""&&n[1]!=""){let e=decodeURIComponent(n[1]);if(e.startsWith('"')&&e.endsWith('"')||e.startsWith("{")&&e.endsWith("}")||e.startsWith("[")&&e.endsWith("]")){try{e=JSON.parse(e)}catch(e){t(e)}}else if(zd(e)){e=Number(e)}r.set(n[0].toLowerCase(),e)}else if(n.length>2){t(`unexpected '=' character in the URL parameter value for '${n[0]}'`)}else{t(`Invalid url parameter: '${e}'`)}}return r}function $d(e,t=""){const n=e.state?.embedder;const r=t=>{if(t.origin!==n.origin)return;if(t.data=="getActiveMassSession"){window.removeEventListener("message",r);o.postMessage({state:e.state},n.origin);if(n.origin!=window.location.origin){setTimeout((()=>{try{window.close()}catch(e){console.log(e);window.open(window.location,"_self").close()}}),500)}}};window.addEventListener("message",r,false);setTimeout((()=>window.removeEventListener("message",r)),8e3);if(n.origin!=window.location.origin){confirm(`Another window will open to recover the saved session. When the next window opens,`+`\n- You may need to allow popups.`+`\n- You may have to refresh it.`+`\n- After the session is recovered, this browser window should automatically close.`);document.body.innerHTML=`\n\t\t\t<div style='margin: 20px; padding: 20px; font-size: 24px'>\n\t\t\t\tPlease close this browser tab. The recovered session should visible in another browser tab.\n\t\t\t</div>\n\t\t`}const o=window.open(n.href,"_blank")}async function Fd(e){const t=Ud();if(t.has("appcard")){const n=await import("./adSandbox-5753745b.js").then((function(e){return e.a}));const r=t.get("appcard");const o=t.get("example");const i=await Dl("/cards/index.json");e.app.drawer.opts.genomes=e.genomes;e.app.drawer.opts.fromApp=true;e.app.drawer.opts.app={cardsPath:"cards"};const s=i.elements.findIndex((e=>e.sandboxJson==r||e.sandboxHtml==r||e.name.toUpperCase().includes(r.toUpperCase())));if(i.elements[s]?.configFeature){const t=JSON.parse(sessionStorage.getItem("optionalFeatures"));if(!t[i.elements[s].configFeature]){vd(e.holder,`This track or app is not enabled on this site.`);return}}if(o){e.app.drawer.opts.example=o}if(s<=0){const t=[...i.elements.filter((e=>e.type=="nestedCard"))];let o,s;t.findIndex((e=>{for(const[t,n]of e.children.entries()){if(n.sandboxJson==r||n.sandboxHtml==r||n.name.toUpperCase().includes(r.toUpperCase())){o=e;s=t}}}));if(!o){vd(e.holder,`Invalid app card.`);return}n.openSandbox(o.children[s],e.app.drawer.opts)}else{n.openSandbox(i.elements[s],e.app.drawer.opts)}return}if(t.has("gdcbamslice")){const n=await import("./bam-4e0df8b6.js");n.bamsliceui({genomes:e.genomes,holder:e.holder,debugmode:e.debugmode,stream2download:t.has("stream2download")});return}if(t.has("gdcmaf")){const t=await import("./maf-10526648.js");t.gdcMAFui({holder:e.holder,debugmode:e.debugmode});return}if(t.has("gdcsinglecell")){const t=await import("./singlecell-281a74a6.js");t.gdcSinglecellUi({holder:e.holder,debugmode:e.debugmode});return}if(t.has("termdb")){const n=t.get("termdb");const r=typeof n==="string"?JSON.parse(n):n;const o={holder:e.holder,state:r};const i=await import("./app-5aa892cb.js");i.appInit(o);return}if(t.has("massnative")){const n=t.get("massnative");const[r,o]=n.split(",");if(!r||!o)throw'value is not "genome,dslabel"';const i={holder:e.holder,genome:e.genomes[r],state:{genome:r,dslabel:o}};if(!i.genome)throw"invalid genome";const s=await import("./app-d9433820.js");s.appInit(i);return}if(t.has("mass")){const n=t.get("mass");const r=typeof n==="string"?JSON.parse(n):n;const o={debug:e.app.debugmode,holder:e.holder,state:r};if(r.genome){o.genome=e.genomes[r.genome]}else if(r?.vocab?.genome){o.genome=e.genomes[r.vocab.genome]}const i=await import("./app-d9433820.js");i.appInit(o);return}if(t.has("mass-session-file")||t.has("mass-session-url")){let n;if(t.has("mass-session-file")){const r=t.get("mass-session-file");const o=await Vl(`/textfile`,{method:"POST",body:JSON.stringify({file:r})});const i=JSON.parse(o.text);n={debug:e.app.debugmode,holder:e.holder,state:i,genome:e.genomes[i.vocab.genome]}}if(t.has("mass-session-url")){const r=t.get("mass-session-url");const o=await Vl("/urltextfile",{method:"POST",body:JSON.stringify({url:r})});const i=JSON.parse(o.text);n={debug:e.app.debugmode,holder:e.holder,state:i,genome:e.genomes[i.vocab.genome]}}const r=await import("./app-d9433820.js");r.appInit(n);return}if(t.has("mass-session-id")){const n=t.get("mass-session-id");const r=t.get("src");let o;if(r=="browser"){const e=localStorage.getItem("savedMassSessions");const t=JSON.parse(e);o={state:t[n]}}else{const e={headers:{},body:{id:n}};if(r=="cred"){const n=t.get("dslabel");const r=t.get("route");e.body.dslabel=n;e.body.route=r;e.body.route=r;const o=localStorage.getItem("jwtByDsRoute")||`{}`;this.jwtByDsRoute=JSON.parse(o);const i=this.jwtByDsRoute[n][r];e.headers.authorization=`Bearer ${btoa(i)}`}o=await Vl(`/massSession`,e);if(o.error)throw o.error}const i=o.state?.embedder;if(i&&i.origin!=window.location.origin){$d(o);return}const s={debug:e.app.debugmode,holder:e.holder,state:o.state,genome:e.genomes[o.state.vocab.genome],sessionDaysLeft:o.sessionDaysLeft,sessionId:n};const a=await import("./app-d9433820.js");a.appInit(s);return}if(t.has("genome")&&e.selectgenome){const n=t.get("genome");const r=[...e.selectgenome.node().childNodes];const o=r.findIndex((e=>e.value==n));if(o==-1){vd(e.holder,`Invalid genome: ${n}. Please provide an available genome from this list: ${r.map((e=>e.value)).join(", ").replace(/,(?=[^,]*$)/,", or")}`);return}e.selectgenome.node().selectedIndex=o;e.selectgenome.node().dispatchEvent(new Event("change"))}if(t.has("hicfile")||t.has("hicurl")){let n,r,o;if(t.has("hicfile")){n=t.get("hicfile");o=n.split("/").pop()}else{r=t.get("hicurl");o=r.split("/").pop()}const i=t.get("genome");if(!i)throw"genome is required for hic";const s=e.genomes[i];if(!s)throw"invalid genome";const a={genome:s,file:n,url:r,name:o,hostURL:e.hostURL,enzyme:t.get("enzyme"),holder:e.holder};const l=await import("./HicApp-fe8682af.js");await l.hicInit(a);return}if(t.has("singlecell")){if(!t.has("genome"))throw'"genome" is required for "singlecell"';const n=t.get("genome");const r=e.genomes[n];if(!r)throw"invalid genome: "+n;const o=await import("./singlecell-1c3bee25.js");o.init({genome:r,jsonfile:t.get("singlecell")},e.holder);return}if(t.has("mavbfile")){if(!t.has("genome"))throw'"genome" is required for "mavb"';const n=t.get("genome");const r=e.genomes[n];if(!r)throw"invalid genome: "+n;const o=await import("./mavb-0d28dd97.js");o.mavbparseinput({genome:r,hostURL:e.hostURL,file:t.get("mavbfile")},(()=>{}),e.holder,e.jwt);return}if(t.has("mavburl")){if(!t.has("genome"))throw'"genome" is required for "mavb"';const n=t.get("genome");const r=e.genomes[n];if(!r)throw"invalid genome: "+n;const o=await import("./mavb-0d28dd97.js");o.mavbparseinput({genome:r,hostURL:e.hostURL,url:t.get("mavburl")},(()=>{}),e.holder,e.jwt);return}if(t.has("scatterplot")){if(!t.has("genome"))throw'"genome" is required for "scatterplot"';const n=t.get("genome");const r=e.genomes[n];if(!r)throw"invalid genome: "+n;let o;if(t.has("mdsjson")||t.has("mdsjsonurl")){const e=t.get("mdsjsonurl");const n=t.get("mdsjson");o=await Ld(n,e)}if(t.has("tsnejson")){const e=t.get("tsnejson");const n=await Fl("textfile",{file:e});if(n.error)throw n.error;else if(n.text){o={mdssamplescatterplot:{analysisdata:JSON.parse(n.text)}}}}o.mdssamplescatterplot.genome=r;const i=await import("./mds.samplescatterplot-5a4ee6b6.js");i.init(o.mdssamplescatterplot,e.holder,false);return}if(t.has("block")){if(!t.has("genome"))throw"missing genome for block";const n=t.get("genome");const r=e.genomes[n];if(!r)throw"invalid genome: "+n;const o={nobox:1,hostURL:e.hostURL,jwt:e.jwt,holder:e.holder,genome:r,dogtag:n,debugmode:e.debugmode};let i=null;let s=null;if(t.has("position")){const e=t.get("position").split(";");if(e[0]){const t=e[0].split(/[:-]/);const n=t[0];const r=Number.parseInt(t[1]);const o=Number.parseInt(t[2]);if(!n)throw"chr missing";if(Number.isNaN(r)||Number.isNaN(o))throw"Invalid start/stop value in position";i={chr:n,start:r,stop:o}}const n=[];for(let t=1;t<e.length;t++){if(!e[t])continue;const r=e[t].split(/[:-]/);const o=r[0];const i=Number.parseInt(r[1]);const s=Number.parseInt(r[2]);if(!o)throw"subpanel chr missing";if(Number.isNaN(i)||Number.isNaN(s))throw"Invalid start/stop value in subpanel position";n.push({chr:o,start:i,stop:s,width:600,leftborder:"rgba(200,0,0,.1)",leftpad:5})}if(n.length){o.subpanels=n}}if(t.has("regions")){s=[];for(const e of t.get("regions").split(",")){const t=e.split(/[:-]/);t[0];const n=Number.parseInt(t[1]);const r=Number.parseInt(t[2]);if(Number.isNaN(n)||Number.isNaN(r))throw"Invalid start/stop value in regions";s.push({chr:t[0],start:n,stop:r})}}if(!i&&!s){if(r.defaultcoord){i={chr:r.defaultcoord.chr,start:r.defaultcoord.start,stop:r.defaultcoord.stop}}}if(i){o.chr=i.chr;o.start=i.start;o.stop=i.stop}else if(s){o.rglst=s}if(t.has("hlregion")){const e=[];for(const n of t.get("hlregion").split(",")){const t=Pf(n,r,true);if(t)e.push(t)}if(e.length)o.hlregions=e}o.datasetqueries=Pd(t);o.tklst=await qd(t,r);ic(e.genomes[n],o.tklst);Dd(t,o.tklst);const a=await import("./block-2f22e7fd.js").then((function(e){return e.c}));new a.Block(o);return}if(t.has("gene")){const n=t.get("gene");if(n.length==0)throw"zero length query string";const r={hostURL:e.hostURL,query:n,holder:e.holder,variantPageCall_snv:e.variantPageCall_snv,samplecart:e.samplecart,debugmode:e.debugmode};{let n;for(let t in e.genomes){if(e.genomes[t].isdefault){n=t;break}}if(t.has("genome")){n=t.get("genome")}if(!n)throw"No genome, and none set as default";r.genome=e.genomes[n];if(!r.genome)throw"invalid genome: "+n}if(t.has("dataset")){r.dataset=t.get("dataset").split(",")}if(t.has("hlaachange")){r.hlaachange=new Map;for(const e of t.get("hlaachange").split(",")){r.hlaachange.set(e,false)}}if(t.has("hlregion")){const e=[];for(const n of t.get("hlregion").split(",")){const t=Pf(n,r.genome,true);if(t)e.push(t)}if(e.length)r.hlregions=e}r.tklst=await qd(t,r.genome);Dd(t,r.tklst);r.datasetqueries=Pd(t);await kd(r);return}if(t.has("disco")){const n=t.get("genome");const r=e.genomes[n];if(!r)throw"genome missing";const o=t.get("dslabel");if(!o)throw"dslabel missing";const i=t.get("sample");if(!i)throw"sample_id missing";const s=(await import("./FilterRxComp-cb149666.js").then((function(e){return e.k}))).vocabInit({state:{genome:n,dslabel:o}});const a=await s.getTermdbConfig();await(await import("./plot.disco-ccdf741c.js")).default(a,o,{sample_id:i},e.holder,r);return}if(t.has("study")){const n=t.get("study");if(n!=""){Jf(e.genomes,n,e.holder,e.hostURL,undefined,false,e.app||{debugmode:e.debugmode,instanceTracker:e.instanceTracker||{},callbacks:e.callbacks||{}})}}}function Pd(e){if(!e.has("mds"))return;const t=e.get("mds").split(",");if(t[0]&&t[1]){const n={dataset:t[0],querykey:t[1]};if(e.has("sample")){n.singlesample={name:e.get("sample")};n.getsampletrackquickfix=true}return[n]}return}async function qd(e,t){const n=[];if(e.has("mds3")){const t=e.get("mds3").split(",");for(const r of t){const t={type:vc.mds3,dslabel:r};if(e.has("token"))t.token=e.get("token");if(e.has("filterobj"))t.filterObj=e.get("filterobj");n.push(t)}}if(e.has("mds3bcffile")){const[t,r]=e.get("mds3bcffile").split(",");if(t&&r){n.push({type:vc.mds3,name:t,bcf:{file:r}})}}if(e.has("mds3bcfurl")){const[t,r,o]=e.get("mds3bcfurl").split(",");if(t&&r){n.push({type:vc.mds3,name:t,bcf:{url:r,indexURL:o}})}}if(e.has("arcfile")){const t=e.get("arcfile").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:vc.hicstraw,name:t[e],bedfile:t[e+1],mode_hm:false,mode_arc:true})}}}if(e.has("mdsjson")||e.has("mdsjsonurl")){const t=e.get("mdsjsonurl");const r=e.get("mdsjson");const o=await Md(r,t);n.push(...o)}if(e.has("tkjsonfile")){const r=await Fl("textfile",{file:e.get("tkjsonfile")});if(r.error)throw r.error;if(!r.text)throw".text missing";const o=JSON.parse(r.text);for(const e of o){if(e.isfacet){if(!t.tkset)t.tkset=[];if(!e.tracks)throw".tracks[] missing from a facet table";if(!Array.isArray(e.tracks))throw".tracks[] not an array from a facet table";e.tklst=e.tracks;delete e.tracks;for(const t of e.tklst){if(!t.assay)throw".assay missing from a facet track";if(!t.sample)throw".sample missing from a facet track";t.tkid=Math.random().toString()}t.tkset.push(e)}else{n.push(e)}}}if(e.has("bamfile")){const t=e.get("bamfile").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:vc.bam,name:t[e],file:t[e+1]})}}}if(e.has("bamurl")){const t=e.get("bamurl").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:vc.bam,name:t[e],url:t[e+1]})}}}if(e.has("bedjfile")){const t=e.get("bedjfile").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:vc.bedj,name:t[e],file:t[e+1]})}}}if(e.has("bedjurl")){const t=e.get("bedjurl").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:vc.bedj,name:t[e],url:t[e+1]})}}}if(e.has("hictkfile")||e.has("hictkurl")){const t=e.has("hictkfile");const r=e.get(t?"hictkfile":"hictkurl").split(",");const o=e.has("hictknorm")?e.get("hictknorm").split(","):null;for(let e=0;e<r.length;e+=3){if(r[e]&&r[e+1]&&r[e+2]){const i={type:vc.hicstraw,name:r[e],enzyme:r[e+1],normalizationmethod:o?o[e/3]:null};if(t){i.file=r[e+2]}else{i.url=r[e+2]}n.push(i)}}}if(e.has("ldfile")){const t=e.get("ldfile").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:vc.ld,name:t[e],file:t[e+1]})}}}if(e.has("bigwigfile")){const t=e.get("bigwigfile").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:vc.bigwig,name:t[e],file:t[e+1],scale:{auto:1}})}}}if(e.has("bigwigurl")){const t=e.get("bigwigurl").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:vc.bigwig,name:t[e],url:t[e+1],scale:{auto:1}})}}}if(e.has("junctionfile")){const t=e.get("junctionfile").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:vc.junction,name:t[e],tracks:[{file:t[e+1]}]})}}}if(e.has("junctionurl")){const t=e.get("junctionurl").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:vc.junction,name:t[e],tracks:[{url:t[e+1]}]})}}}if(e.has("vcffile")){const t=e.get("vcffile").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:"vcf",name:t[e],file:t[e+1]})}}}if(e.has("vcfurl")){const t=e.get("vcfurl").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:"vcf",name:t[e],url:t[e+1]})}}}if(e.has("aicheckfile")){const t=e.get("aicheckfile").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:"aicheck",name:t[e],file:t[e+1]})}}}if(e.has("bampilefile")){const t=e.get("bampilefile").split(",");let r=null;if(e.has("bampilelink")){r=e.get("bampilelink").split(",").map(decodeURIComponent)}for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){const o={type:vc.bampile,name:t[e],file:t[e+1]};if(r&&r[e/2]){o.link=r[e/2]}n.push(o)}}}if(e.has("svcnvfpkmurl")){const t=e.get("svcnvfpkmurl").split(",");const r=t[0];const o={};for(let e=1;e<t.length;e+=2){o[t[e]]=t[e+1]}if(o.svcnv||o.vcf){const e={type:vc.mdssvcnv,name:r};if(o.svcnv){e.url=o.svcnv}if(o.vcf){e.checkvcf={url:o.vcf,indexURL:o.vcfindex}}if(o.fpkm){e.checkexpressionrank={datatype:"FPKM",url:o.fpkm,indexURL:o.fpkmindex}}n.push(e)}}if(e.has("svcnvfpkmfile")){const t=e.get("svcnvfpkmfile").split(",");const r=t[0];const o={};for(let e=1;e<t.length;e+=2){o[t[e]]=t[e+1]}if(o.svcnv||o.vcf){const e={type:vc.mdssvcnv,name:r};if(o.svcnv){e.file=o.svcnv}if(o.vcf){e.checkvcf={file:o.vcf}}if(o.fpkm){e.checkexpressionrank={datatype:"FPKM",file:o.fpkm}}n.push(e)}}if(e.has("mdsjunctionfile")){const t=e.get("mdsjunctionfile").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:"mdsjunction",name:t[e],file:t[e+1]})}}}if(e.has("junctionmatrix")){const t=e.get("junctionmatrix").split(",");for(let e=0;e<t.length;e+=2){if(t[e]&&t[e+1]){n.push({type:"mdsjunction",name:t[e],file2:t[e+1]})}}}if(e.has("junctionrnapeg")){const 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t={error0(e){Nc(t.holder0,e)},debugmode:false,callbacks:e.callbacks||{sjcharts:{}},instanceTracker:e.instanceTracker||{sjcharts:{}}};Hd(e,t);if(!t.instanceTracker.sjcharts){t.instanceTracker.sjcharts={}}if(!t.callbacks.sjcharts){t.callbacks.sjcharts={}}if(e.clear){it(".sja_pane").remove();return}t.holder=ot(e.holder?e.holder:document.body).append("div").attr("class","sja_root_holder").attr("data-ppclientversion",`2.78.0`).style("font","1em Arial, sans-serif").style("color","black");t.sandbox_header=e.sandbox_header||undefined;if(e.jwt){sessionStorage.setItem("jwt",e.jwt)}sessionStorage.setItem("suppressErrors",JSON.stringify(e.suppressErrors));if(e.variantPageCall_snv){t.variantPageCall_snv=e.variantPageCall_snv}if(e.samplecart){t.samplecart=e.samplecart}if(e.base_zindex){Ac({setzindex:e.base_zindex})}const n=e.serverData||e.termdb&&e.termdb.serverData;const r=Vl("genomes",{},{serverData:n});return r.then((async n=>{if(n.error)throw{message:"Cannot get genomes: 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import("./AppHeader-67cea623.js");const o=new r.AppHeader({headtip:Gd,app:t,data:n,jwt:e.jwt});await o.makeheader()}t.holder0=t.holder.append("div").style("margin","20px");const r=await Jd(e,t);return r||t})).catch((e=>{t.holder.text(e.message||e);if(e.stack)console.log(e.stack)}))}Bd.getStatus=async function e(t=""){return await fetch("/healthcheck").then((e=>e.json())).then((e=>{const n={clientVersion:document.querySelector(".sja_root_holder")?.dataset.ppclientversion,versionInfo:e.versionInfo};if(t=="log")console.info(n);else if(t=="json")return JSON.stringify(n);else return n})).catch(console.error)};const Vd=document&&document.currentScript&&document.currentScript.src||"";function Hd(e,t){if(e.host){t.hostURL=e.host}else if(window.location.hostname=="localhost"){const e=Ud();if(e.has("hosturl"))t.hostURL=e.get("hosturl");else if(window.testHost){t.hostURL=window.testHost}else{const n=e.get("hostname");const r=e.get("hostport");const o=window.location.protocol+"//";if(n&&r)t.hostURL=o+n+":"+r;else if(n)t.hostURL=o+n;else if(r)t.hostURL=o+window.location.hostname+":"+r}}if(!t.hostURL){if(Vd.includes("://")){t.hostURL=Vd.split("://")[0]+"://"+Vd.split("://")[1].split("/")[0]}else{t.hostURL=""}}if(t.hostURL.endsWith("/"))t.hostURL=t.hostURL.slice(0,-1);sessionStorage.setItem("hostURL",t.hostURL)}async function Jd(e,t){if(e.genome&&t.selectgenome){for(let n=0;n<t.selectgenome.node().childNodes.length;n++){if(t.selectgenome.node().childNodes[n].value==e.genome){t.selectgenome.property("selectedIndex",n);break}}}if(e.mclassOverride){if(!e.mclassOverride.mclassName)e.mclassOverride.mclassName="Class";for(const t in e.mclassOverride.classes){const n=Ks[t];if(n){Object.assign(n,e.mclassOverride.classes[t])}}}if(e.singlecell){hu(e.singlecell,t);return t}if(e.fimo){Zd(e.fimo,t);return t}if(e.mdssurvivalplot){if(e.genome)e.mdssurvivalplot.genome=e.genome;Wd(e.mdssurvivalplot,t);return t}if(e.mdssamplescatterplot){if(e.genome)e.mdssamplescatterplot.genome=e.genome;Xd(e.mdssamplescatterplot,t);return t}if(e.samplematrix){e.samplematrix.jwt=e.jwt;Qd(e.samplematrix,t);return t}if(e.hic){e.hic.jwt=e.jwt;Kd(e.hic,t);return t}if(e.block){return tu(e,t)}if(e.study){Jf(t.genomes,e.study,t.holder0,t.hostURL,e.jwt,false,t);return t}if(e.studyview){const n=e.studyview;n.hostURL=e.host;const r=n.genome||e.genome;n.genome=t.genomes[r];n.hostURL=t.hostURL;n.jwt=e.jwt;n.holder=t.holder0;cd(n);return t}if(await Yd(e,t)){return t}if(e.fusioneditor){nu(e,t);return t}if(e.genefusion){bu(e,t);return t}if(e.mavolcanoplot){fu(e,t);return t}if(e.twodmaf){du(e,t);return t}if(e.junctionbymatrix){pu(e,t);return}if(e.selectGenomeWithTklst){await ru(e,t);return}if(e.disco){return await _u(e,t)}if(e.geneSearch4GDCmds3){return await ou(e,t)}if(e.launchGdcMatrix){return await iu(e,t)}if(e.launchGdcHierCluster){return await su(e,t)}if(e.launchGdcMaf){return await lu(e,t)}if(e.launchGdcScRNAseq){return await au(e,t)}if(e.parseurl&&location.search.length){try{await Fd({app:t,genomes:t.genomes,hostURL:t.hostURL,variantPageCall_snv:t.variantPageCall_snv,samplecart:t.samplecart,holder:t.holder,selectgenome:t.selectgenome,genome_browser_btn:t.genome_browser_btn,debugmode:t.debugmode})}catch(e){t.error0(e);console.error(e.stack||e)}}if(e.project){let n=undefined;if(e.project.uionly)n=t.holder0;sd(0,0,t.genomes,t.hostURL,n,t.sandbox_header)}if(e.termdb){await gu(e.termdb,t)}if(e.maftimeline){uu(e,t)}if(e.gdcbamslice){return await cu(e,t)}if(e.mass){return await vu(e,t)}if(e.tkui){mu(e,t)}if(e.massSessionId){const n=await Vl(`/massSession?id=${e.massSessionId}`);if(n.error)throw n.error;const r={debug:t.debugmode,holder:t.holder0,state:n.state,genome:t.genomes[n.state.vocab.genome],massSessionDuration:n.massSessionDuration,getDatasetAccessToken:e.getDatasetAccessToken,addLoginCallback:e.addLoginCallback};const o=await import("./app-d9433820.js");o.appInit(r);return}if(e.massSessionFile||e.massSessionURL){let n;if(e.massSessionFile){const t=e.massSessionFile;const r=await Vl(`/textfile`,{method:"POST",body:JSON.stringify({file:t})});if(r.error)throw r.error;n=JSON.parse(r.text)}else{const t=e.massSessionURL;const r=await Vl(`/urltextfile`,{method:"POST",body:JSON.stringify({url:t})});if(r.error)throw r.error;n=JSON.parse(r.text)}const r={debug:t.debugmode,holder:t.holder0,state:n,genome:t.genomes[n.vocab.genome]};const o=await import("./app-d9433820.js");o.appInit(r);return}if(e.profileHome){const t=await import("./profileHome-121aaddb.js");t.init(e);return}}async function Yd(e,t){if(e.p){e.gene=e.p;delete e.p}if(e.gene2canonicalisoform){if(!e.genome)throw".genome missing for gene2canonicalisoform";const t=await Dl("gene2canonicalisoform?genome="+e.genome+"&gene="+e.gene2canonicalisoform);if(t.error)throw t.error;if(!t.isoform)throw"no canonical isoform for given gene accession";e.gene=t.isoform}if(e.mds3_ssm2canonicalisoform){if(!e.genome)throw".genome missing";if(!e.mds3_ssm2canonicalisoform.ssm_id)throw".ssm_id missing from mds3_ssm2canonicalisoform";if(!e.mds3_ssm2canonicalisoform.dslabel)throw".dslabel missing from mds3_ssm2canonicalisoform";const t=await Dl("mds3?"+"genome="+e.genome+"&dslabel="+e.mds3_ssm2canonicalisoform.dslabel+"&ssm2canonicalisoform=1"+"&ssm_id="+e.mds3_ssm2canonicalisoform.ssm_id);if(t.error)throw t.error;if(!t.isoform)throw"no isoform found for given ssm_id";e.gene=t.isoform;if(e.tracks){const t=e.tracks.find((t=>t.dslabel==e.mds3_ssm2canonicalisoform.dslabel));if(t){t.hlssmid=e.mds3_ssm2canonicalisoform.ssm_id}}}if(e.gene){eu(e,t);return true}return false}async function Xd(e,t){if(!e.genome){t.error0("missing genome for mdssamplescatterplot");return}const n=t.genomes[e.genome];if(!n){t.error0("invalid genome for mdssamplescatterplot");return}e.genome=n;if(e.dataset){e.mds=n.datasets[e.dataset];if(!e.mds){t.error0("invalid dataset for mdssamplescatterplot");return}e.dslabel=e.dataset;delete e.dataset;if(e.mds.mdsIsUninitiated){const t=await Vl(`getDataset?genome=${e.genome.name}&dsname=${e.dslabel}`);if(t.error)throw t.error;if(!t.ds)throw"ds missing";Object.assign(e.mds,t.ds);delete e.mds.mdsIsUninitiated}}else if(e.analysisdata);else if(e.analysisdata_file){try{const t=await Fl("textfile",{file:e.analysisdata_file});if(t.error)throw tmp.error;else if(t.text)e.analysisdata=JSON.parse(t.text)}catch(e){t.error0(e);return}}else{t.error0("neither .dataset or .analysisdata is given");return}import("./mds.samplescatterplot-5a4ee6b6.js").then((n=>{n.init(e,t.holder0,t.debugmode)}))}function Wd(e,t){if(!e.genome){t.error0("missing genome for mdssurvivalplot");return}const n=t.genomes[e.genome];if(!n){t.error0("invalid genome for mdssurvivalplot");return}e.genome=n;if(!e.dataset){t.error0("missing dataset for mdssurvivalplot");return}e.mds=n.datasets[e.dataset];if(!e.mds){t.error0("invalid dataset for mdssurvivalplot");return}delete e.dataset;if(e.plotlist){for(const t of e.plotlist){t.renderplot=1}}import("./mds.survivalplot-b04947ee.js").then((n=>{n.init(e,t.holder0,t.debugmode)}))}function Zd(e,t){if(!e.genome){t.error0("missing genome for fimo");return}const n=t.genomes[e.genome];if(!n){t.error0("invalid genome for fimo");return}e.genome=n;e.div=t.holder0;import("./mds.fimo-929b9e65.js").then((t=>{t.init(e)}))}function Kd(e,t){if(!e.genome){t.error0("missing genome for hic");return}e.genome=t.genomes[e.genome];if(!e.genome){t.error0("invalid genome for hic");return}if(!e.file){t.error0("missing file for hic");return}e.hostURL=t.hostURL;e.holder=t.holder0;import("./HicApp-fe8682af.js").then((async n=>{await n.hicInit(e,t.debugmode)}))}function Qd(e,t){if(!e.genome){t.error0("missing genome for launching samplematrix");return}e.genome=t.genomes[e.genome];if(!e.genome){t.error0("invalid genome for samplematrix");return}e.hostURL=t.hostURL;e.holder=t.holder0;e.debugmode=t.debugmode;import("./samplematrix-2bb2480b.js").then((t=>{new t.Samplematrix(e)}))}async function eu(e,t){if(!e.genome){t.error0("Cannot embed: must specify reference genome");return}if(e.tracks){for(const t of e.tracks){if(t.type=="mds3"&&t.dslabel)continue;t.iscustom=true}}if(e.tkjsonfile){if(!e.tracks)e.tracks=[];const t=new Map([["tkjsonfile",e.tkjsonfile]]);const n=await qd(t,genomeobj);for(const t of n){e.tracks.push(t)}}const n={jwt:e.jwt,hostURL:t.hostURL,query:e.gene,genome:t.genomes[e.genome],holder:t.holder0,variantPageCall_snv:t.variantPageCall_snv,samplecart:t.samplecart,debugmode:t.debugmode,datasetqueries:e.datasetqueries,mset:e.mset,tklst:e.tracks,gmmode:e.gmmode,mclassOverride:e.mclassOverride,hide_dsHandles:e.hide_dsHandles,onloadalltk_always:e.onloadalltk_always};if(e.dataset){n.dataset=e.dataset.split(",");n.legacyDsFilter=e.legacyDsFilter;if(e.hidedatasetexpression){n.hidedatasetexpression=true}}if(e.hidegenecontrol){n.hidegenecontrol=true}if(e.hidegenelegend){n.hidegenelegend=true}let r=null;if(e.hlaachange){r=new Map;if(Array.isArray(e.hlaachange)){for(const t of e.hlaachange){if(t.name){r.set(t.name,t)}}}else{for(const t of e.hlaachange.split(",")){r.set(t,false)}}if(r.size){n.hlaachange=r}}if(e.hlvariants){n.hlvariants=e.hlvariants}await kd(n)}async function tu(e,t){if(!e.genome){t.error0("Cannot embed: must specify reference genome");return}const n=t.genomes[e.genome];if(!n){t.error0("Invalid genome: "+e.genome);return}if(e.study){Jf(t.genomes,e.study,t.holder0,t.hostURL,e.jwt,true,t)}if(e.studyview);if(e.tracks){for(const n of e.tracks){if(n.type==vc.mds3&&n.dslabel)continue;if(n.mdsjsonfile||n.mdsjsonurl){try{const t=await Md(n.mdsjsonfile,n.mdsjsonurl);e.tracks=e.tracks.filter((e=>e!=n));e.tracks.push(...t)}catch(e){vd(t.holder0,e)}}n.iscustom=true}}if(e.tkjsonfile){if(!e.tracks)e.tracks=[];const t=new Map([["tkjsonfile",e.tkjsonfile]]);const r=await qd(t,n);for(const t of r){e.tracks.push(t)}}const r={genome:n,hostURL:t.hostURL,jwt:e.jwt,holder:t.holder0,nativetracks:e.nativetracks,tklst:e.tracks,debugmode:t.debugmode,legendimg:e.legendimg};if(e.width){const n=Number.parseInt(e.width);if(Number.isNaN(n))return t.error0("browser width must be integer");r.width=n}if(e.subpanels){if(!Array.isArray(e.subpanels))return t.error0("subpanels is not array");const n=[];for(const r of e.subpanels){if(!r.chr){t.error0("missing chr in one subpanel");continue}if(!r.start||!r.stop){t.error0("missing start or stop in one subpanel");continue}if(!r.width){r.width=400}if(!r.leftpad){r.leftpad=5}n.push(r)}if(n.length){r.subpanels=n}}if(e.nobox){r.nobox=true}else{r.dogtag=e.dogtag||e.genome}if(e.chr&&Number.isInteger(e.start)){r.chr=e.chr;r.start=e.start;r.stop=Number.isInteger(e.stop)?e.stop:e.start+1}else if(e.position){const t=Pf(e.position,n);if(t){r.chr=t.chr;r.start=t.start;r.stop=t.stop}}else if(e.positionbygene){try{const t=await lf(e.genome,e.positionbygene);if(t&&t[0]){const e=t[0];r.chr=e.chr;r.start=e.start;r.stop=e.stop}}catch(e){t.error0(e)}}if(!r.chr){r.chr=n.defaultcoord.chr;r.start=n.defaultcoord.start;r.stop=n.defaultcoord.stop}if(e.datasetqueries){r.datasetqueries=e.datasetqueries}if(e.hlregions){const t=[];for(const r of e.hlregions){const e=Pf(r,n,true);if(e)t.push(e)}if(t.length)r.hlregions=t}const o=Ud();if(o){if(o.has("position")){const e=Pf(o.get("position"),n);if(e){r.chr=e.chr;r.start=e.start;r.stop=e.stop}}if(o.has("hlregion")){const e=[];for(const t of o.get("hlregion").split(",")){const r=Pf(t,n,true);if(r){e.push(r)}}if(e.length){r.hlregions=e}}if(o.has("bedgraphdotfile")){if(!r.tklst)r.tklst=[];const e=o.get("bedgraphdotfile").split(",");for(let t=0;t<e.length;t+=2){if(e[t]&&e[t+1]){r.tklst.push({type:vc.bedgraphdot,name:e[t],file:e[t+1]})}}}}return import("./block-2f22e7fd.js").then((function(e){return e.c})).then((e=>{t.block=new e.Block(r);return t}))}function nu(e,t){if(e.fusioneditor.uionly){const[n,r,o,i,s]=td(t.holder0,t.genomes);import("./svmr-89b80ea2.js").then((a=>{a.svmrui([null,n,r,o,i,s],t.genomes,t.hostURL,e.jwt)}));return}const n=t.genomes[e.genome];if(!n){t.error0("Invalid genome: "+e.genome);return}import("./svmr-89b80ea2.js").then((r=>{r.svmrparseinput(e.fusioneditor,t.error0,n,t.holder0,t.hostURL,e.jwt)}))}async function ru(e,t){const n=await import("./selectGenomeWithTklst-71344af2.js");await n.init(e,t.holder0,t.genomes)}async function ou(e,t){const n=await import("./lollipop-40c4c5cb.js");return await n.init(e,t.holder0,t.genomes)}async function iu(e,t){const n=await import("./oncomatrix-c29e6de9.js");return await n.init(e,t.holder0,t.genomes)}async function su(e,t){const n=await import("./geneExpClustering-a2cf1bb9.js");return await n.init(e,t.holder0,t.genomes)}async function au(e,t){const n=await import("./singlecell-281a74a6.js");return await n.init(e,t.holder0,t.genomes)}async function lu(e,t){const n=await import("./maf-10526648.js");return await n.gdcMAFui({holder:t.holder0,filter0:e.filter0,callbacks:e.callbacks||{},debugmode:e.debugmode})}function cu(e,t){return import("./bam-4e0df8b6.js").then((n=>n.bamsliceui({genomes:t.genomes,holder:t.holder0,hideTokenInput:e.gdcbamslice.hideTokenInput,callbacks:e.gdcbamslice.callbacks||{},filter0:e.filter0,stream2download:e.gdcbamslice.stream2download,inputValue:e.gdcbamslice.inputValue})))}function fu(e,t){if(e.mavolcanoplot.uionly){import("./mavb-0d28dd97.js").then((n=>{n.mavbui(t.genomes,t.hostURL,e.jwt,t.holder0,t.sandbox_header)}));return}const n=t.genomes[e.genome];if(!n){t.error0("Invalid genome: "+e.genome);return}e.mavolcanoplot.hostURL=t.hostURL;e.mavolcanoplot.genome=n;import("./mavb-0d28dd97.js").then((n=>{n.mavbparseinput(e.mavolcanoplot,t.error0,t.holder0,e.jwt)}))}function du(e,t){if(e.twodmaf.uionly){import("./2dmaf-7dddba15.js").then((e=>{e.d2mafui(t.genomes,t.holder0)}));return}const n=t.genomes[e.genome];if(!n){t.error0("Invalid genome: "+e.genome);return}e.twodmaf.hostURL=t.hostURL;e.twodmaf.genome=n;import("./2dmaf-7dddba15.js").then((n=>{n.d2mafparseinput(e.twodmaf,t.holder0)}))}function uu(e,t){if(e.maftimeline.uionly){import("./maftimeline-a77349ad.js").then((e=>{e.default(t.genomes,t.holder0,t.sandbox_header)}))}}function pu(e,t){if(e.junctionbymatrix.uionly){import("./block.tk.junction.textmatrixui-15bd752c.js").then((n=>{n.default(t.genomes,t.hostURL,e.jwt,t.holder0)}))}}async function hu(e,t){try{const n=t.genomes[e.genome];if(!n)throw"Invalid genome: "+e.genome;e.genome=n;const r=await import("./singlecell-1c3bee25.js");await r.init(e,t.holder0)}catch(e){t.error0("Error launching single cell viewer: "+e);if(e.stack)console.log(e.stack)}}async function mu(e,t){if(e.tkui=="bigwig"){const e=await import("./block.tk.bigwig.ui-fb6401ee.js");e.bigwigUI(t.genomes,t.holder)}if(e.tkui=="databrowser"){const e=await import("./databrowser.ui-8ace51c3.js");e.init_databrowserUI(t.holder,t.debugmode)}if(e.tkui=="genefusion"){const e=await import("./genefusion.ui-e219424a.js");e.init_geneFusionUI(t.holder,t.genomes,t.debugmode)}if(e.tkui=="disco"){const e=await import("./Disco.UI-ea58ee03.js");e.init_discoplotUI(t.holder,t.genomes,t.debugmode)}}async function gu(e,t){if(!e.holder)e.holder=t.holder0;import("./app-5aa892cb.js").then((t=>{t.appInit(e)}))}async function bu(e,t){try{const n=t.genomes[e.genome];if(!n)throw"Invalid genome: "+e.genome;const r=await import("./fusion.parse-7e3a6071.js");const o=await r.parseFusion({line:e.genefusion.text,genome:n,positionType:e.genefusion.positionType});await yu(o.pairlst[0].a,n);await yu(o.pairlst[0].b,n);const i=await import("./svgraph-76e34d5e.js");i.default({pairlst:o.pairlst,genome:n,holder:t.holder})}catch(e){t.error0(e)}}async function yu(e,t){const n=await Vl("genelookup",{body:{genome:t.name,input:e.isoform,deep:1}});if(n.error)throw n.error;if(!Array.isArray(n.gmlst))throw"gmlst not array";const r=n.gmlst.find((t=>t.isoform==e.isoform));if(!r)throw"no match to isoform";e.chr=r.chr;e.name=r.name;e.gm={isoform:r.isoform}}async function vu(e,t){const n=e.mass;if("debugmode"in t)n.debug=t.debugmode;if(!n.holder)n.holder=t.holder0;if(n.state){if(n.state.genome){n.genome=t.genomes[n.state.genome]}else if(n.state?.vocab?.genome){n.genome=t.genomes[n.state.vocab.genome]}}n.getDatasetAccessToken=e.getDatasetAccessToken;n.addLoginCallback=e.addLoginCallback;const r=sessionStorage.getItem("hostURL");if(window.opener&&r!=window.location.origin){n.embeddedSessionState=JSON.parse(sessionStorage.getItem("embeddedSessionState")||`{}`);const e=t=>{if(t.origin!=window.location.origin&&t.origin!==r)return;if(t.data.state){window.removeEventListener("message",e);Object.assign(n.embeddedSessionState,t.data.state);sessionStorage.setItem("embeddedSessionState",JSON.stringify(n.embeddedSessionState))}};window.addEventListener("message",e,false);setTimeout((()=>window.removeEventListener("message",e)),1e3);let t;try{if(window.opener.origin){t=window.opener.origin}else{t=r}}catch(e){t=r}try{window.opener.postMessage("getActiveMassSession",t)}catch(e){console.log(e)}}const o=await import("./app-d9433820.js");return await o.appInit(n)}function wu(e){e.tkset=[];e.isoformcache=new Map;e.junctionframecache=new Map;e.isoformmatch=(t,n,r)=>{if(!t)return null;const o=t.toUpperCase();if(!e.isoformcache.has(o))return null;const i=e.isoformcache.get(o);if(i.length==1)return i[0];if(!n){console.log("no chr provided for matching with "+o);return i[0]}let s=null;for(const e of i){if(e.chr.toUpperCase()==n.toUpperCase()&&e.start<=r&&e.stop>=r){s=e}}if(s)return s;for(const e of i){if(e.chr.toUpperCase()==n.toUpperCase())return e}return null};e.chrlookup={};for(const t in e.majorchr){e.chrlookup[t.toUpperCase()]={name:t,len:e.majorchr[t],major:true}}if(e.minorchr){for(const t in e.minorchr){e.chrlookup[t.toUpperCase()]={name:t,len:e.minorchr[t]}}}if(!e.tracks){e.tracks=[]}for(const t of e.tracks){t.tkid=Math.random().toString()}for(const t in e.datasets){const n=e.datasets[t];if(n.isMds);else if(n.isMds3){if(!n.label)return"ds.label missing"}}return null}async function _u(e,t){if(!e.genome)throw'"genome" parameter missing';const n=t.genomes[e.genome];if(!n)throw"unknown genome";if(e.disco.sample_id){const r=(await import("./FilterRxComp-cb149666.js").then((function(e){return e.k}))).vocabInit({state:{genome:n.name,dslabel:e.disco.dslabel}});const o=await r.getTermdbConfig();await(await import("./plot.disco-ccdf741c.js")).default(o,e.disco.dslabel,{sample_id:e.disco.sample_id},t.holder,n);return}else{const r=await import("./launch.adhoc-98dc0421.js");return await r.launch(e.disco,n,t.holder0)}}export{Wn as $,ba as A,Zs as B,Qa as C,sc as D,Il as E,El as F,ec as G,zd as H,Hr as I,$d as J,bl as K,Qf as L,oc as M,Es as N,_a as O,Sl as P,Us as Q,Ds as R,Ws as S,Ts as T,Rc as U,Rd as V,$r as W,Nl as X,yl as Y,Ac as Z,Yr as _,sf as a,Mc as a$,zo as a0,yr as a1,br as a2,Nt as a3,xt as a4,Cr as a5,Is as a6,Dl as a7,St as a8,ac as a9,za as aA,Hc as aB,Xc as aC,Pc as aD,qc as aE,wc as aF,qf as aG,Sc as aH,zs as aI,Gf as aJ,Ra as aK,_s as aL,Lf as aM,lc as aN,Pa as aO,Hs as aP,Ys as aQ,Js as aR,yd as aS,bd as aT,Rf as aU,Jc as aV,bc as aW,xd as aX,it as aY,Tc as aZ,Rs as a_,Vf as aa,$c as ab,kc as ac,vc as ad,La as ae,Cs as af,Cc as ag,cc as ah,_d as ai,Da as aj,Ps as ak,Sa as al,Aa as am,Qs as an,Ga as ao,Gs as ap,Xs as aq,Vs as ar,Bs as as,qs as at,va as au,ga as av,pa as aw,ha as ax,ma as ay,ia as az,Vl as b,tf as b$,Ic as b0,Ec as b1,Ta as b2,Oc as b3,Lc as b4,Bc as b5,Zc as b6,Kc as b7,qa as b8,uc as b9,mc as bA,ho as bB,ca as bC,da as bD,fa as bE,ra as bF,oa as bG,Uc as bH,cf as bI,ad as bJ,ld as bK,Rn as bL,sl as bM,$n as bN,el as bO,tl as bP,nl as bQ,rl as bR,ol as bS,il as bT,Vc as bU,$s as bV,$a as bW,Fs as bX,Fc as bY,rf as bZ,al as b_,dc as ba,Ha as bb,Df as bc,mf as bd,Va as be,Ba as bf,ta as bg,na as bh,la as bi,pc as bj,hc as bk,gc as bl,Dc as bm,td as bn,zc as bo,lt as bp,jt as bq,vr as br,Vr as bs,ur as bt,Ct as bu,Zn as bv,af as bw,lf as bx,Ns as by,_c as bz,Pf as c,Yc as c0,as as c1,Bd as c2,Sd as c3,ot as d,kd as e,ic as f,qd as g,hl as h,dl as i,Nc as j,Wc as k,Ls as l,pl as m,id as n,ul as o,xc as p,Fl as q,Qt as r,e as s,wd as t,Ud as u,nf as v,ef as w,Ff as x,vd as y,Ks as z};