@sjcrh/proteinpaint-client 2.224.2 → 2.226.0

package/dist/chunk-CKO54XWB.js

@@ -1,54 +0,0 @@
-import {
-  addGeneSearchbox
-} from "./chunk-ZIMAIUZD.js";
-import {
-  Menu
-} from "./chunk-CNFTQSNE.js";
-
-// termdb/handlers/snp.ts
-var SearchHandler = class {
-  init(opts) {
-    this.callback = opts.callback;
-    const geneSearch = addGeneSearchbox({
-      tip: new Menu({ padding: "0px" }),
-      genome: opts.genomeObj,
-      row: opts.holder,
-      searchOnly: "snp",
-      allowVariant: true,
-      callback: () => this.selectSnp(geneSearch)
-    });
-  }
-  async selectSnp(geneSearch) {
-    const { chr, ref, alt, fromWhat } = geneSearch;
-    if (!chr || !ref || !alt || !fromWhat) throw "missing chr, ref, alt, or fromWhat of snp";
-    let start, stop;
-    if (!geneSearch.start && !geneSearch.stop) {
-      if (geneSearch.pos) {
-        start = geneSearch.pos - 1;
-        stop = geneSearch.pos;
-      } else {
-        throw "missing coordinate of snp";
-      }
-    } else {
-      start = geneSearch.start;
-      stop = geneSearch.stop;
-    }
-    const term = {
-      id: fromWhat,
-      chr,
-      start,
-      stop,
-      name: fromWhat,
-      ref,
-      alt: typeof alt == "string" ? [alt] : alt,
-      // is string if input to geneSearch was in variant or hgvs format // TODO: update genesearch.ts to parse alternative alleles from any input format into arrays
-      type: "snp"
-    };
-    this.callback(term);
-  }
-};
-
-export {
-  SearchHandler
-};
-//# sourceMappingURL=chunk-CKO54XWB.js.map

package/dist/chunk-COWLQ74R.js

@@ -1,82 +0,0 @@
-import {
-  addGeneSearchbox,
-  getGEunit,
-  getSelectedSampleTypes,
-  mayGetSampleTypeLabel,
-  renderSampleTypeSelect,
-  renderSampleTypesByTermsSelect,
-  table2col
-} from "./chunk-ZIMAIUZD.js";
-import {
-  Menu
-} from "./chunk-CNFTQSNE.js";
-import {
-  TermTypes
-} from "./chunk-R2H22S4J.js";
-
-// termdb/handlers/geneExpression.ts
-var SearchHandler = class {
-  init(opts) {
-    this.callback = opts.callback;
-    this.app = opts.app;
-    this.dom = {};
-    const holder = opts.holder.append("div").style("padding", "10px 0px");
-    this.dom.sampleTypeDiv = holder.append("div");
-    this.mayRenderSampleTypeSelect();
-    const geneSearch = addGeneSearchbox({
-      tip: new Menu({ padding: "0px" }),
-      genome: opts.genomeObj,
-      row: holder,
-      searchOnly: "gene",
-      callback: () => this.selectGene(geneSearch)
-    });
-    holder.select(".sja_genesearchinput").style("margin", "0px");
-  }
-  mayRenderSampleTypeSelect() {
-    this.dom.sampleTypeDiv.selectAll("*").remove();
-    this.querySampleTypes = this.app.vocabApi.termdbConfig?.queries.geneExpression.sampleTypes;
-    this.querySampleTypesByTerms = this.app.vocabApi.termdbConfig?.queries.geneExpression.sampleTypesByTerms;
-    if (Array.isArray(this.querySampleTypes) && this.querySampleTypes.length >= 2 || this.querySampleTypesByTerms) {
-      const table = table2col({ holder: this.dom.sampleTypeDiv, margin: "0px 0px 15px 0px" });
-      const [td1, td2] = table.addRow();
-      td1.text("Sample Type");
-      td2.style("padding-left", "10px");
-      if (this.querySampleTypesByTerms) {
-        this.sampleTypeSelect = renderSampleTypesByTermsSelect(
-          td2,
-          this.querySampleTypesByTerms,
-          this.app.vocabApi.termdbConfig
-        );
-      } else {
-        this.sampleTypeSelect = renderSampleTypeSelect(td2, this.querySampleTypes, this.app.vocabApi.termdbConfig);
-      }
-    }
-  }
-  async selectGene(geneSearch) {
-    const gene = geneSearch?.geneSymbol;
-    if (!gene) throw new Error("No gene selected");
-    const sampleTypes = getSelectedSampleTypes({
-      sampleTypeSelect: this.sampleTypeSelect,
-      querySampleTypes: this.querySampleTypes,
-      querySampleTypesByTerms: this.querySampleTypesByTerms
-    });
-    if (this.sampleTypeSelect && !sampleTypes?.length) {
-      return;
-    }
-    const unit = getGEunit(this.app.vocabApi);
-    const name = `${gene} ${unit}`;
-    const term = { gene, name, type: TermTypes.GENE_EXPRESSION, sampleTypes };
-    term.sampleTypeLabel = mayGetSampleTypeLabel({
-      sampleTypeSelect: this.sampleTypeSelect,
-      querySampleTypes: this.querySampleTypes,
-      querySampleTypesByTerms: this.querySampleTypesByTerms,
-      termdbConfig: this.app.vocabApi.termdbConfig
-    });
-    this.callback(term);
-  }
-};
-
-export {
-  SearchHandler
-};
-//# sourceMappingURL=chunk-COWLQ74R.js.map

package/dist/chunk-COWLQ74R.js.map

@@ -1,7 +0,0 @@
-{
-  "version": 3,
-  "sources": ["../termdb/handlers/geneExpression.ts"],
-  "sourcesContent": ["import {\n\tMenu,\n\taddGeneSearchbox,\n\trenderSampleTypeSelect,\n\trenderSampleTypesByTermsSelect,\n\tgetSelectedSampleTypes,\n\tmayGetSampleTypeLabel,\n\ttable2col\n} from '#dom'\nimport { TermTypes } from '#types'\nimport { getGEunit } from '#tw/geneExpression'\n\nexport class SearchHandler {\n\tcallback: any\n\tapp: any\n\tdom: any\n\tquerySampleTypes?: any[]\n\tquerySampleTypesByTerms?: any\n\tsampleTypeSelect?: any\n\tinit(opts) {\n\t\tthis.callback = opts.callback\n\t\tthis.app = opts.app\n\t\tthis.dom = {}\n\t\tconst holder = opts.holder.append('div').style('padding', '10px 0px')\n\t\tthis.dom.sampleTypeDiv = holder.append('div')\n\t\tthis.mayRenderSampleTypeSelect()\n\t\tconst geneSearch = addGeneSearchbox({\n\t\t\ttip: new Menu({ padding: '0px' }),\n\t\t\tgenome: opts.genomeObj,\n\t\t\trow: holder,\n\t\t\tsearchOnly: 'gene',\n\t\t\tcallback: () => this.selectGene(geneSearch)\n\t\t})\n\t\tholder.select('.sja_genesearchinput').style('margin', '0px')\n\t}\n\n\tmayRenderSampleTypeSelect() {\n\t\tthis.dom.sampleTypeDiv.selectAll('*').remove()\n\t\tthis.querySampleTypes = this.app.vocabApi.termdbConfig?.queries.geneExpression.sampleTypes\n\t\tthis.querySampleTypesByTerms = this.app.vocabApi.termdbConfig?.queries.geneExpression.sampleTypesByTerms\n\t\tif ((Array.isArray(this.querySampleTypes) && this.querySampleTypes.length >= 2) || this.querySampleTypesByTerms) {\n\t\t\t// render sample type select\n\t\t\tconst table = table2col({ holder: this.dom.sampleTypeDiv, margin: '0px 0px 15px 0px' })\n\t\t\tconst [td1, td2] = table.addRow()\n\t\t\ttd1.text('Sample Type')\n\t\t\ttd2.style('padding-left', '10px')\n\t\t\tif (this.querySampleTypesByTerms) {\n\t\t\t\tthis.sampleTypeSelect = renderSampleTypesByTermsSelect(\n\t\t\t\t\ttd2,\n\t\t\t\t\tthis.querySampleTypesByTerms,\n\t\t\t\t\tthis.app.vocabApi.termdbConfig\n\t\t\t\t)\n\t\t\t} else {\n\t\t\t\tthis.sampleTypeSelect = renderSampleTypeSelect(td2, this.querySampleTypes, this.app.vocabApi.termdbConfig)\n\t\t\t}\n\t\t}\n\t}\n\n\tasync selectGene(geneSearch) {\n\t\tconst gene = geneSearch?.geneSymbol\n\t\tif (!gene) throw new Error('No gene selected')\n\t\tconst sampleTypes = getSelectedSampleTypes({\n\t\t\tsampleTypeSelect: this.sampleTypeSelect,\n\t\t\tquerySampleTypes: this.querySampleTypes,\n\t\t\tquerySampleTypesByTerms: this.querySampleTypesByTerms\n\t\t})\n\t\tif (this.sampleTypeSelect && !sampleTypes?.length) {\n\t\t\treturn\n\t\t}\n\t\tconst unit = getGEunit(this.app.vocabApi)\n\t\tconst name = `${gene} ${unit}`\n\t\tconst term: any = { gene, name, type: TermTypes.GENE_EXPRESSION, sampleTypes }\n\t\tterm.sampleTypeLabel = mayGetSampleTypeLabel({\n\t\t\tsampleTypeSelect: this.sampleTypeSelect,\n\t\t\tquerySampleTypes: this.querySampleTypes,\n\t\t\tquerySampleTypesByTerms: this.querySampleTypesByTerms,\n\t\t\ttermdbConfig: this.app.vocabApi.termdbConfig\n\t\t})\n\t\tthis.callback(term)\n\t}\n}\n"],
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-  "names": []
-}

package/dist/chunk-CU434U4N.js

@@ -1,35 +0,0 @@
-import {
-  appInit
-} from "./chunk-ZIMAIUZD.js";
-import {
-  TermTypes
-} from "./chunk-R2H22S4J.js";
-
-// termdb/handlers/ssGSEA.ts
-var SearchHandler = class {
-  async init(opts) {
-    this.callback = opts.callback;
-    this.app = opts.app;
-    const genesetDbName = Object.keys(opts.genomeObj.termdbs || {})[0];
-    if (!genesetDbName) throw "genesetDbName missing";
-    await appInit({
-      holder: opts.holder,
-      state: {
-        dslabel: genesetDbName,
-        genome: opts.genomeObj.name,
-        nav: { header_mode: "search_only" }
-      },
-      tree: {
-        click_term: (term) => {
-          this.callback({ id: term.id, type: TermTypes.SSGSEA, name: term.name });
-        }
-      }
-    });
-    opts.holder.select("input.tree_search").attr("data-testid", "sjpp-ssgsea-search");
-  }
-};
-
-export {
-  SearchHandler
-};
-//# sourceMappingURL=chunk-CU434U4N.js.map

package/dist/chunk-CZOJUH3C.js

@@ -1,30 +0,0 @@
-import {
-  defaultMaxPairwiseTestGroups
-} from "./chunk-ZUXXBQ7D.js";
-import {
-  plotColor
-} from "./chunk-R2H22S4J.js";
-
-// plots/boxplot/defaults.ts
-function getDefaultBoxplotSettings(app, overrides = {}) {
-  const defaults = {
-    plotLength: 550,
-    color: plotColor,
-    displayMode: "default",
-    labelPad: 10,
-    isLogScale: false,
-    isVertical: false,
-    orderByMedian: false,
-    rowHeight: 50,
-    rowSpace: 15,
-    removeOutliers: false,
-    showAssocTests: true,
-    maxPairwiseTestGroups: defaultMaxPairwiseTestGroups
-  };
-  return Object.assign(defaults, overrides);
-}
-
-export {
-  getDefaultBoxplotSettings
-};
-//# sourceMappingURL=chunk-CZOJUH3C.js.map

package/dist/chunk-D22DJFFZ.js

@@ -1,254 +0,0 @@
-import {
-  first_genetrack_tolist
-} from "./chunk-ZIMAIUZD.js";
-import {
-  HYPER_COLOR,
-  HYPO_COLOR
-} from "./chunk-ZUXXBQ7D.js";
-
-// plots/dmr/settings/defaults.ts
-function getDefaultDMRSettings(opts) {
-  const overrides = opts.settings || {};
-  const dm = opts?.app?.vocabApi?.termdbConfig?.queries?.dnaMethylation;
-  const chr = opts?.coordinateOverride?.chr;
-  const elementScale = dm?.regionAnalysis == "element" || Array.isArray(dm?.cpgChroms) && !!chr && !dm.cpgChroms.includes(chr);
-  const defaults = {
-    blockWidth: 800,
-    pad: elementScale ? 1e5 : 2e3,
-    lambda: elementScale ? 5e4 : 1e3,
-    C: 2,
-    fdr_cutoff: 0.05,
-    colors: {
-      group1: "#3b5ee6",
-      group2: "#c04e00",
-      hyper: HYPER_COLOR,
-      hypo: HYPO_COLOR
-    },
-    maxLoessRegion: 25e4,
-    minProbesForCi: 10,
-    maxRegionSize: 5e6
-  };
-  if (overrides.colors) {
-    Object.assign(defaults.colors, overrides.colors);
-    delete overrides.colors;
-  }
-  return Object.assign(defaults, overrides);
-}
-
-// plots/dmr/viewModel/DmrViewModel.ts
-var CCRE_TRACK_NAME = "ENCODE cCREs";
-var DmrViewModel = class {
-  constructor(dmrResult, config, genomeObj, queryChr, queryStart, queryStop) {
-    const { settings } = config;
-    const dmrBedItems = this.makeDmrBedItems(dmrResult, settings);
-    const sigCpgBedItems = this.makeSigCpgBedItems(dmrResult, settings, queryChr, queryStart, queryStop);
-    const xRange = (queryStop ?? 0) - (queryStart ?? 0);
-    const loess = dmrResult.diagnostic?.loess;
-    const showLoess = !!(loess && loess.group1_fitted.length > 0 && loess.group2_fitted.length > 0);
-    const showDots = xRange <= settings.dmr.maxLoessRegion;
-    const betaTrackResult = dmrResult.diagnostic ? this.renderBetaTrack(
-      dmrResult.diagnostic,
-      config,
-      settings.dmr.blockWidth,
-      showLoess,
-      showDots,
-      queryStart,
-      queryStop
-    ) : void 0;
-    this.viewData = {
-      tklst: this.buildTrackList(dmrBedItems, sigCpgBedItems, genomeObj, betaTrackResult?.img),
-      legendRows: this.buildLegendData(
-        config,
-        dmrResult.dmrs,
-        sigCpgBedItems,
-        showLoess,
-        showDots,
-        betaTrackResult?.showCi ?? false
-      ),
-      diagnostic: dmrResult.diagnostic,
-      dmrs: dmrResult.dmrs,
-      dmrBedItems,
-      showLoess,
-      showDots
-    };
-  }
-  buildTrackList(dmrBedItems, sigCpgBedItems, genomeObj, betaTrackImg) {
-    const tklst = [];
-    first_genetrack_tolist(genomeObj, tklst);
-    const ccre = (genomeObj?.tracks || []).find((t) => t.name == CCRE_TRACK_NAME);
-    if (ccre) tklst.push(structuredClone(ccre));
-    tklst.push({ type: "bedj", name: "DMRs", bedItems: dmrBedItems });
-    tklst.push({ type: "bedj", name: "Sig. CpGs", bedItems: sigCpgBedItems });
-    if (betaTrackImg) {
-      tklst.push({
-        type: "bigwig",
-        name: "Per-CpG Means",
-        height: 150,
-        imgData: betaTrackImg
-      });
-    }
-    return tklst;
-  }
-  buildLegendData(config, dmrs, sigCpgBedItems, showLoess, showDots, showCi) {
-    const { colors } = config.settings.dmr;
-    const g1 = config.group1Name || "Group 1";
-    const g2 = config.group2Name || "Group 2";
-    const meansItems = [];
-    if (showDots) {
-      meansItems.push({ text: `${g1} (control)`, color: colors.group1 }, { text: `${g2} (case)`, color: colors.group2 });
-    }
-    if (showLoess) {
-      const ciLabel = showCi ? " + 95% CI" : "";
-      meansItems.push(
-        { text: `${g1} LOESS trend${ciLabel}`, color: colors.group1, style: showCi ? "shaded" : "dashed" },
-        { text: `${g2} LOESS trend${ciLabel}`, color: colors.group2, style: showCi ? "shaded" : "dashed" }
-      );
-    }
-    const rows = [{ label: "Per-CpG Means", items: meansItems }];
-    const hasHyper = dmrs.some((d) => d.direction === "hyper");
-    const hasHypo = dmrs.some((d) => d.direction === "hypo");
-    if (hasHyper || hasHypo) {
-      const items = [];
-      if (hasHyper) items.push({ text: "Hypermethylated", color: colors.hyper });
-      if (hasHypo) items.push({ text: "Hypomethylated", color: colors.hypo });
-      rows.push({ label: "DMR", items });
-    }
-    if (sigCpgBedItems.length) {
-      const items = [];
-      const hasHyperCpg = sigCpgBedItems.some((b) => b.color === colors.hyper);
-      const hasHypoCpg = sigCpgBedItems.some((b) => b.color === colors.hypo);
-      if (hasHyperCpg) items.push({ text: "Hyper (FDR sig.)", color: colors.hyper });
-      if (hasHypoCpg) items.push({ text: "Hypo (FDR sig.)", color: colors.hypo });
-      rows.push({ label: "Sig. CpGs", items });
-    }
-    return rows;
-  }
-  /**
-   * Render the per-CpG means scatter plot to an offscreen canvas and return
-   * a data URI suitable for the bigwig imgData track.
-   */
-  renderBetaTrack(diagnostic, config, blockWidth, showLoess, showDots, queryStart, queryStop) {
-    const { probes } = diagnostic;
-    if (!probes.positions.length) return void 0;
-    const { colors, fdr_cutoff, minProbesForCi } = config.settings.dmr;
-    const dpr = typeof window !== "undefined" && window.devicePixelRatio > 1 ? window.devicePixelRatio : 1;
-    const width = blockWidth;
-    const height = 150;
-    const canvas = document.createElement("canvas");
-    canvas.width = width * dpr;
-    canvas.height = height * dpr;
-    const ctx = canvas.getContext("2d");
-    if (!ctx) return void 0;
-    ctx.scale(dpr, dpr);
-    const xMin = queryStart ?? probes.positions[0];
-    const xMax = queryStop ?? probes.positions[probes.positions.length - 1];
-    const xRange = xMax - xMin || 1;
-    const scaleX = (val) => (val - xMin) / xRange * width;
-    const scaleY = (val) => height - val * height;
-    ctx.clearRect(0, 0, width, height);
-    let showCi = false;
-    if (showLoess && diagnostic.loess) {
-      const { loess } = diagnostic;
-      const firstProbePos = probes.positions[0];
-      const lastProbePos = probes.positions[probes.positions.length - 1];
-      showCi = probes.positions.length >= minProbesForCi;
-      for (const [fitted, ciLower, ciUpper, color] of [
-        [loess.group1_fitted, loess.group1_ci_lower, loess.group1_ci_upper, colors.group1],
-        [loess.group2_fitted, loess.group2_ci_lower, loess.group2_ci_upper, colors.group2]
-      ]) {
-        if (!fitted.length) continue;
-        const lPos = loess.positions;
-        let iStart = 0;
-        let iEnd = lPos.length - 1;
-        while (iStart < lPos.length && lPos[iStart] < firstProbePos) iStart++;
-        while (iEnd >= 0 && lPos[iEnd] > lastProbePos) iEnd--;
-        if (iStart > iEnd) continue;
-        if (showCi) {
-          ctx.globalAlpha = 0.12;
-          ctx.fillStyle = color;
-          ctx.beginPath();
-          for (let i = iStart; i <= iEnd; i++) {
-            ctx.lineTo(scaleX(lPos[i]), scaleY(Math.max(0, Math.min(1, ciUpper[i]))));
-          }
-          for (let i = iEnd; i >= iStart; i--) {
-            ctx.lineTo(scaleX(lPos[i]), scaleY(Math.max(0, Math.min(1, ciLower[i]))));
-          }
-          ctx.closePath();
-          ctx.fill();
-        }
-        ctx.globalAlpha = 0.8;
-        ctx.strokeStyle = color;
-        ctx.lineWidth = 2;
-        ctx.setLineDash(showCi ? [] : [6, 4]);
-        ctx.beginPath();
-        for (let i = iStart; i <= iEnd; i++) {
-          ctx.lineTo(scaleX(lPos[i]), scaleY(Math.max(0, Math.min(1, fitted[i]))));
-        }
-        ctx.stroke();
-        ctx.setLineDash([]);
-      }
-    }
-    if (!showDots) {
-      ctx.globalAlpha = 1;
-      return { img: { minv: 0, maxv: 1, src: canvas.toDataURL("image/png") }, showCi };
-    }
-    for (let i = 0; i < probes.positions.length; i++) {
-      const x = scaleX(probes.positions[i]);
-      const isSig = probes.fdr[i] < fdr_cutoff;
-      const alpha = isSig ? 0.85 : 0.3;
-      ctx.globalAlpha = alpha;
-      ctx.fillStyle = colors.group1;
-      const m1 = probes.mean_group1[i];
-      if (m1 != null) {
-        ctx.beginPath();
-        ctx.arc(x, scaleY(m1), 4, 0, Math.PI * 2);
-        ctx.fill();
-      }
-      ctx.fillStyle = colors.group2;
-      const m2 = probes.mean_group2[i];
-      if (m2 != null) {
-        ctx.beginPath();
-        ctx.arc(x, scaleY(m2), 4, 0, Math.PI * 2);
-        ctx.fill();
-      }
-    }
-    ctx.globalAlpha = 1;
-    return { img: { minv: 0, maxv: 1, src: canvas.toDataURL("image/png") }, showCi };
-  }
-  makeDmrBedItems(dmrResult, settings) {
-    return dmrResult.dmrs.map((dmr) => {
-      const negLog = -Math.log10(Math.max(dmr.min_smoothed_fdr, 1e-300));
-      const alpha = Math.round(Math.min(255, Math.max(50, negLog / 10 * 255)));
-      const hex = alpha.toString(16).padStart(2, "0");
-      const base = dmr.direction === "hyper" ? settings.dmr.colors.hyper : settings.dmr.colors.hypo;
-      return { chr: dmr.chr, start: dmr.start, stop: dmr.stop, color: base + hex };
-    });
-  }
-  makeSigCpgBedItems(dmrResult, settings, chr, queryStart, queryStop) {
-    const diag = dmrResult.diagnostic;
-    if (!diag) return [];
-    const { probes } = diag;
-    const items = [];
-    const minDeltaBeta = 0.05;
-    for (let i = 0; i < probes.positions.length; i++) {
-      if (probes.fdr[i] >= settings.dmr.fdr_cutoff) continue;
-      const pos = probes.positions[i];
-      if (queryStart != null && queryStop != null && (pos < queryStart || pos > queryStop)) continue;
-      const mg1 = probes.mean_group1[i];
-      const mg2 = probes.mean_group2[i];
-      if (mg1 == null || mg2 == null) continue;
-      const deltaBeta = mg2 - mg1;
-      if (Math.abs(deltaBeta) < minDeltaBeta) continue;
-      const color = deltaBeta >= 0 ? settings.dmr.colors.hyper : settings.dmr.colors.hypo;
-      items.push({ chr, start: pos, stop: pos + 1, color });
-    }
-    return items;
-  }
-};
-
-export {
-  getDefaultDMRSettings,
-  CCRE_TRACK_NAME,
-  DmrViewModel
-};
-//# sourceMappingURL=chunk-D22DJFFZ.js.map

package/dist/chunk-D22DJFFZ.js.map

@@ -1,7 +0,0 @@
-{
-  "version": 3,
-  "sources": ["../plots/dmr/settings/defaults.ts", "../plots/dmr/viewModel/DmrViewModel.ts"],
-  "sourcesContent": ["import type { DMRSettings } from './Settings.ts'\n\n// direction colours are shared with the server-rendered scan Manhattan\nexport { HYPER_COLOR, HYPO_COLOR } from '#shared/dmrColors.js'\nimport { HYPER_COLOR, HYPO_COLOR } from '#shared/dmrColors.js'\n\nexport function getDefaultDMRSettings(opts: any): DMRSettings {\n\tconst overrides = opts.settings || {}\n\t/* A dataset with no CpG-level matrix runs the region analysis on its element matrix, where one\n\trow is a cCRE, not a CpG. Those sit ~10kb apart against a CpG's ~100bp, so the CpG-scale window\n\tand kernel below would frame one element and smooth nothing. Scaled to element spacing instead.\n\tponytail: fixed values, not derived from the matrix's actual spacing \u2014 worth deriving only if a\n\tdataset shows up whose element density is far off this one's. The user can pan/zoom either way. */\n\tconst dm = opts?.app?.vocabApi?.termdbConfig?.queries?.dnaMethylation\n\t/* Per chromosome, not per dataset: a cohort with some shards built runs CpG resolution where one\n\texists and elements everywhere else (server resolveMethylationMatrix), so a dataset-wide flag gave\n\tthe fallback chromosomes a CpG-scale window over rows ~10 kb apart. cpgChroms is sent only for a\n\tshard-backed dataset without a genome-wide file. */\n\tconst chr = opts?.coordinateOverride?.chr\n\tconst elementScale =\n\t\tdm?.regionAnalysis == 'element' || (Array.isArray(dm?.cpgChroms) && !!chr && !dm.cpgChroms.includes(chr))\n\tconst defaults = {\n\t\tblockWidth: 800,\n\t\tpad: elementScale ? 100_000 : 2000,\n\t\tlambda: elementScale ? 50_000 : 1000,\n\t\tC: 2,\n\t\tfdr_cutoff: 0.05,\n\t\tcolors: {\n\t\t\tgroup1: '#3b5ee6',\n\t\t\tgroup2: '#c04e00',\n\t\t\thyper: HYPER_COLOR,\n\t\t\thypo: HYPO_COLOR\n\t\t},\n\t\tmaxLoessRegion: 250_000,\n\t\tminProbesForCi: 10,\n\t\tmaxRegionSize: 5_000_000\n\t}\n\n\t// Deep-merge colors so hyper/hypo defaults are preserved\n\t// when only group colors are overridden\n\tif (overrides.colors) {\n\t\tObject.assign(defaults.colors, overrides.colors)\n\t\tdelete overrides.colors\n\t}\n\n\treturn Object.assign(defaults, overrides)\n}\n", "import { first_genetrack_tolist } from '#common/1stGenetk'\n\n/** Name of the regulatory-element track in the genome config, if it declares one. */\nexport const CCRE_TRACK_NAME = 'ENCODE cCREs'\nimport type { TermdbDmrSuccessResponse, DmrDiagnostic } from '#types'\nimport type { DmrConfig, BedItem, LegendRow, DmrViewData } from '../DmrTypes.ts'\n\nexport class DmrViewModel {\n\tviewData: DmrViewData\n\n\tconstructor(\n\t\tdmrResult: TermdbDmrSuccessResponse,\n\t\tconfig: DmrConfig,\n\t\tgenomeObj: any,\n\t\tqueryChr: string,\n\t\tqueryStart?: number,\n\t\tqueryStop?: number\n\t) {\n\t\tconst { settings } = config\n\t\tconst dmrBedItems = this.makeDmrBedItems(dmrResult, settings)\n\t\tconst sigCpgBedItems = this.makeSigCpgBedItems(dmrResult, settings, queryChr, queryStart, queryStop)\n\n\t\tconst xRange = (queryStop ?? 0) - (queryStart ?? 0)\n\t\tconst loess = dmrResult.diagnostic?.loess\n\t\tconst showLoess = !!(loess && loess.group1_fitted.length > 0 && loess.group2_fitted.length > 0)\n\t\tconst showDots = xRange <= settings.dmr.maxLoessRegion\n\n\t\tconst betaTrackResult = dmrResult.diagnostic\n\t\t\t? this.renderBetaTrack(\n\t\t\t\t\tdmrResult.diagnostic,\n\t\t\t\t\tconfig,\n\t\t\t\t\tsettings.dmr.blockWidth,\n\t\t\t\t\tshowLoess,\n\t\t\t\t\tshowDots,\n\t\t\t\t\tqueryStart,\n\t\t\t\t\tqueryStop\n\t\t\t  )\n\t\t\t: undefined\n\n\t\tthis.viewData = {\n\t\t\ttklst: this.buildTrackList(dmrBedItems, sigCpgBedItems, genomeObj, betaTrackResult?.img),\n\t\t\tlegendRows: this.buildLegendData(\n\t\t\t\tconfig,\n\t\t\t\tdmrResult.dmrs,\n\t\t\t\tsigCpgBedItems,\n\t\t\t\tshowLoess,\n\t\t\t\tshowDots,\n\t\t\t\tbetaTrackResult?.showCi ?? false\n\t\t\t),\n\t\t\tdiagnostic: dmrResult.diagnostic,\n\t\t\tdmrs: dmrResult.dmrs,\n\t\t\tdmrBedItems,\n\t\t\tshowLoess,\n\t\t\tshowDots\n\t\t}\n\t}\n\n\tprivate buildTrackList(\n\t\tdmrBedItems: BedItem[],\n\t\tsigCpgBedItems: BedItem[],\n\t\tgenomeObj: any,\n\t\tbetaTrackImg?: { minv: number; maxv: number; src: string }\n\t): any[] {\n\t\tconst tklst: any[] = []\n\t\tfirst_genetrack_tolist(genomeObj, tklst)\n\t\t/* Regulatory context, switched on here rather than left in the Tracks menu. A DMR next to a\n\t\tgene model says where it is; a DMR next to the cCREs says what it is sitting on, which is the\n\t\tquestion the element-level view was answering. Taken from the genome's own declaration by\n\t\tname, so a genome that does not declare it simply renders without the row. */\n\t\tconst ccre = (genomeObj?.tracks || []).find((t: any) => t.name == CCRE_TRACK_NAME)\n\t\tif (ccre) tklst.push(structuredClone(ccre))\n\t\ttklst.push({ type: 'bedj', name: 'DMRs', bedItems: dmrBedItems })\n\t\ttklst.push({ type: 'bedj', name: 'Sig. CpGs', bedItems: sigCpgBedItems })\n\t\tif (betaTrackImg) {\n\t\t\ttklst.push({\n\t\t\t\ttype: 'bigwig',\n\t\t\t\tname: 'Per-CpG Means',\n\t\t\t\theight: 150,\n\t\t\t\timgData: betaTrackImg\n\t\t\t})\n\t\t}\n\t\treturn tklst\n\t}\n\n\tprivate buildLegendData(\n\t\tconfig: DmrConfig,\n\t\tdmrs: TermdbDmrSuccessResponse['dmrs'],\n\t\tsigCpgBedItems: BedItem[],\n\t\tshowLoess: boolean,\n\t\tshowDots: boolean,\n\t\tshowCi: boolean\n\t): LegendRow[] {\n\t\tconst { colors } = config.settings.dmr\n\t\tconst g1 = config.group1Name || 'Group 1'\n\t\tconst g2 = config.group2Name || 'Group 2'\n\t\tconst meansItems: LegendRow['items'] = []\n\t\tif (showDots) {\n\t\t\tmeansItems.push({ text: `${g1} (control)`, color: colors.group1 }, { text: `${g2} (case)`, color: colors.group2 })\n\t\t}\n\t\tif (showLoess) {\n\t\t\tconst ciLabel = showCi ? ' + 95% CI' : ''\n\t\t\tmeansItems.push(\n\t\t\t\t{ text: `${g1} LOESS trend${ciLabel}`, color: colors.group1, style: showCi ? 'shaded' : 'dashed' },\n\t\t\t\t{ text: `${g2} LOESS trend${ciLabel}`, color: colors.group2, style: showCi ? 'shaded' : 'dashed' }\n\t\t\t)\n\t\t}\n\t\tconst rows: LegendRow[] = [{ label: 'Per-CpG Means', items: meansItems }]\n\t\t// Only show DMR legend entries for directions present in the results\n\t\tconst hasHyper = dmrs.some(d => d.direction === 'hyper')\n\t\tconst hasHypo = dmrs.some(d => d.direction === 'hypo')\n\t\tif (hasHyper || hasHypo) {\n\t\t\tconst items: LegendRow['items'] = []\n\t\t\tif (hasHyper) items.push({ text: 'Hypermethylated', color: colors.hyper })\n\t\t\tif (hasHypo) items.push({ text: 'Hypomethylated', color: colors.hypo })\n\t\t\trows.push({ label: 'DMR', items })\n\t\t}\n\t\tif (sigCpgBedItems.length) {\n\t\t\tconst items: LegendRow['items'] = []\n\t\t\tconst hasHyperCpg = sigCpgBedItems.some(b => b.color === colors.hyper)\n\t\t\tconst hasHypoCpg = sigCpgBedItems.some(b => b.color === colors.hypo)\n\t\t\tif (hasHyperCpg) items.push({ text: 'Hyper (FDR sig.)', color: colors.hyper })\n\t\t\tif (hasHypoCpg) items.push({ text: 'Hypo (FDR sig.)', color: colors.hypo })\n\t\t\trows.push({ label: 'Sig. CpGs', items })\n\t\t}\n\t\treturn rows\n\t}\n\n\t/**\n\t * Render the per-CpG means scatter plot to an offscreen canvas and return\n\t * a data URI suitable for the bigwig imgData track.\n\t */\n\tprivate renderBetaTrack(\n\t\tdiagnostic: DmrDiagnostic,\n\t\tconfig: DmrConfig,\n\t\tblockWidth: number,\n\t\tshowLoess: boolean,\n\t\tshowDots: boolean,\n\t\tqueryStart?: number,\n\t\tqueryStop?: number\n\t): { img: { minv: number; maxv: number; src: string }; showCi: boolean } | undefined {\n\t\tconst { probes } = diagnostic\n\t\tif (!probes.positions.length) return undefined\n\n\t\tconst { colors, fdr_cutoff, minProbesForCi } = config.settings.dmr\n\t\tconst dpr = typeof window !== 'undefined' && window.devicePixelRatio > 1 ? window.devicePixelRatio : 1\n\t\tconst width = blockWidth\n\t\tconst height = 150\n\n\t\tconst canvas = document.createElement('canvas')\n\t\tcanvas.width = width * dpr\n\t\tcanvas.height = height * dpr\n\t\tconst ctx = canvas.getContext('2d')\n\t\tif (!ctx) return undefined\n\t\tctx.scale(dpr, dpr)\n\n\t\t// Use the full block view range so dots align with bedj tracks above.\n\t\t// The block stretches the image to fill the view from queryStart to queryStop.\n\t\tconst xMin = queryStart ?? probes.positions[0]\n\t\tconst xMax = queryStop ?? probes.positions[probes.positions.length - 1]\n\t\tconst xRange = xMax - xMin || 1\n\t\tconst scaleX = (val: number) => ((val - xMin) / xRange) * width\n\t\tconst scaleY = (val: number) => height - val * height // beta 0-1\n\n\t\t// Transparent background so block mouse events (yellow line) show through\n\t\tctx.clearRect(0, 0, width, height)\n\n\t\t// DMR region shading omitted \u2014 already shown as a bedj track above\n\n\t\t// Draw LOESS curves with shaded CI regions, clipped to probe data range.\n\t\t// Only show CIs when there are enough probes for a reliable estimate.\n\t\tlet showCi = false\n\t\tif (showLoess && diagnostic.loess) {\n\t\t\tconst { loess } = diagnostic\n\t\t\tconst firstProbePos = probes.positions[0]\n\t\t\tconst lastProbePos = probes.positions[probes.positions.length - 1]\n\t\t\tshowCi = probes.positions.length >= minProbesForCi\n\n\t\t\tfor (const [fitted, ciLower, ciUpper, color] of [\n\t\t\t\t[loess.group1_fitted, loess.group1_ci_lower, loess.group1_ci_upper, colors.group1],\n\t\t\t\t[loess.group2_fitted, loess.group2_ci_lower, loess.group2_ci_upper, colors.group2]\n\t\t\t] as [number[], number[], number[], string][]) {\n\t\t\t\tif (!fitted.length) continue\n\t\t\t\tconst lPos = loess.positions\n\n\t\t\t\t// Find LOESS indices within the range of actual probe positions\n\t\t\t\tlet iStart = 0\n\t\t\t\tlet iEnd = lPos.length - 1\n\t\t\t\twhile (iStart < lPos.length && lPos[iStart] < firstProbePos) iStart++\n\t\t\t\twhile (iEnd >= 0 && lPos[iEnd] > lastProbePos) iEnd--\n\t\t\t\tif (iStart > iEnd) continue\n\n\t\t\t\tif (showCi) {\n\t\t\t\t\t// Draw CI as shaded region\n\t\t\t\t\tctx.globalAlpha = 0.12\n\t\t\t\t\tctx.fillStyle = color\n\t\t\t\t\tctx.beginPath()\n\t\t\t\t\tfor (let i = iStart; i <= iEnd; i++) {\n\t\t\t\t\t\tctx.lineTo(scaleX(lPos[i]), scaleY(Math.max(0, Math.min(1, ciUpper[i]))))\n\t\t\t\t\t}\n\t\t\t\t\tfor (let i = iEnd; i >= iStart; i--) {\n\t\t\t\t\t\tctx.lineTo(scaleX(lPos[i]), scaleY(Math.max(0, Math.min(1, ciLower[i]))))\n\t\t\t\t\t}\n\t\t\t\t\tctx.closePath()\n\t\t\t\t\tctx.fill()\n\t\t\t\t}\n\n\t\t\t\t// Draw LOESS fitted curve (dashed when no CI, solid otherwise)\n\t\t\t\tctx.globalAlpha = 0.8\n\t\t\t\tctx.strokeStyle = color\n\t\t\t\tctx.lineWidth = 2\n\t\t\t\tctx.setLineDash(showCi ? [] : [6, 4])\n\t\t\t\tctx.beginPath()\n\t\t\t\tfor (let i = iStart; i <= iEnd; i++) {\n\t\t\t\t\tctx.lineTo(scaleX(lPos[i]), scaleY(Math.max(0, Math.min(1, fitted[i]))))\n\t\t\t\t}\n\t\t\t\tctx.stroke()\n\t\t\t\tctx.setLineDash([])\n\t\t\t}\n\t\t}\n\n\t\t// Draw dots (hidden for large regions where only LOESS is shown)\n\t\tif (!showDots) {\n\t\t\tctx.globalAlpha = 1\n\t\t\treturn { img: { minv: 0, maxv: 1, src: canvas.toDataURL('image/png') }, showCi }\n\t\t}\n\t\tfor (let i = 0; i < probes.positions.length; i++) {\n\t\t\tconst x = scaleX(probes.positions[i])\n\t\t\tconst isSig = probes.fdr[i] < fdr_cutoff\n\t\t\tconst alpha = isSig ? 0.85 : 0.3\n\n\t\t\t// Group 1 (control)\n\t\t\tctx.globalAlpha = alpha\n\t\t\tctx.fillStyle = colors.group1\n\t\t\tconst m1 = probes.mean_group1[i]\n\t\t\tif (m1 != null) {\n\t\t\t\tctx.beginPath()\n\t\t\t\tctx.arc(x, scaleY(m1), 4, 0, Math.PI * 2)\n\t\t\t\tctx.fill()\n\t\t\t}\n\n\t\t\t// Group 2 (case)\n\t\t\tctx.fillStyle = colors.group2\n\t\t\tconst m2 = probes.mean_group2[i]\n\t\t\tif (m2 != null) {\n\t\t\t\tctx.beginPath()\n\t\t\t\tctx.arc(x, scaleY(m2), 4, 0, Math.PI * 2)\n\t\t\t\tctx.fill()\n\t\t\t}\n\t\t}\n\t\tctx.globalAlpha = 1\n\n\t\treturn { img: { minv: 0, maxv: 1, src: canvas.toDataURL('image/png') }, showCi }\n\t}\n\n\tprivate makeDmrBedItems(dmrResult: TermdbDmrSuccessResponse, settings: DmrConfig['settings']): BedItem[] {\n\t\treturn dmrResult.dmrs.map(dmr => {\n\t\t\t// Map -log10(min_smoothed_fdr) to alpha: more significant = more opaque\n\t\t\tconst negLog = -Math.log10(Math.max(dmr.min_smoothed_fdr, 1e-300))\n\t\t\tconst alpha = Math.round(Math.min(255, Math.max(50, (negLog / 10) * 255)))\n\t\t\tconst hex = alpha.toString(16).padStart(2, '0')\n\t\t\tconst base = dmr.direction === 'hyper' ? settings.dmr.colors.hyper : settings.dmr.colors.hypo\n\t\t\treturn { chr: dmr.chr, start: dmr.start, stop: dmr.stop, color: base + hex }\n\t\t})\n\t}\n\n\tprivate makeSigCpgBedItems(\n\t\tdmrResult: TermdbDmrSuccessResponse,\n\t\tsettings: DmrConfig['settings'],\n\t\tchr: string,\n\t\tqueryStart?: number,\n\t\tqueryStop?: number\n\t): BedItem[] {\n\t\tconst diag = dmrResult.diagnostic\n\t\tif (!diag) return []\n\t\tconst { probes } = diag\n\t\tconst items: BedItem[] = []\n\t\tconst minDeltaBeta = 0.05\n\t\tfor (let i = 0; i < probes.positions.length; i++) {\n\t\t\tif (probes.fdr[i] >= settings.dmr.fdr_cutoff) continue\n\t\t\tconst pos = probes.positions[i]\n\t\t\tif (queryStart != null && queryStop != null && (pos < queryStart || pos > queryStop)) continue\n\t\t\tconst mg1 = probes.mean_group1[i]\n\t\t\tconst mg2 = probes.mean_group2[i]\n\t\t\tif (mg1 == null || mg2 == null) continue\n\t\t\tconst deltaBeta = mg2 - mg1\n\t\t\tif (Math.abs(deltaBeta) < minDeltaBeta) continue\n\t\t\tconst color = deltaBeta >= 0 ? settings.dmr.colors.hyper : settings.dmr.colors.hypo\n\t\t\titems.push({ chr, start: pos, stop: pos + 1, color })\n\t\t}\n\t\treturn items\n\t}\n}\n"],
-  "mappings": 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