@sjcrh/proteinpaint-client 2.223.0 → 2.224.0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/dist/2dmaf-AHG6N6GX.js +1362 -0
- package/dist/AggMatrixInput-A4EATVXG.js +402 -0
- package/dist/AggregateMatrix-3D36XP7Q.js +37 -0
- package/dist/AppHeader-LBFNK6BI.js +826 -0
- package/dist/BoxPlot-JNISSUMV.js +1229 -0
- package/dist/CorrelationVolcano-BXXFXVHQ.js +613 -0
- package/dist/Cuminc-PYG3TJSE.js +1217 -0
- package/dist/DE-QGNB5JKB.js +85 -0
- package/dist/DEinput-YVXCVTCX.js +479 -0
- package/dist/DM-D37YHRJL.js +86 -0
- package/dist/DifferentialAnalysis-TFWK7UE7.js +236 -0
- package/dist/Disco-PXBROYMP.js +3384 -0
- package/dist/Disco.UI-XERJSEDE.js +239 -0
- package/dist/DmrPlot-G3QAPQ5I.js +361 -0
- package/dist/GB-BLGXVCL2.js +1388 -0
- package/dist/GSEA-ZQNLH62K.js +870 -0
- package/dist/GeneExpInput-EYNET6LR.js +38 -0
- package/dist/Geomap-OTF5DRZT.js +80 -0
- package/dist/HicApp-APZFHM2A.js +2240 -0
- package/dist/IDCViewer-Q5PM7G5F.js +10808 -0
- package/dist/NumBinaryEditor-DSQDMP4L.js +274 -0
- package/dist/NumBinaryEditor.unit.spec-DXKUI7ZJ.js +308 -0
- package/dist/NumContEditor-7EYKJTAM.js +100 -0
- package/dist/NumContEditor.unit.spec-3TGAJSIH.js +160 -0
- package/dist/NumCustomBinEditor-7YK4DHNY.js +29 -0
- package/dist/NumCustomBinEditor.unit.spec-UG4QP4SJ.js +393 -0
- package/dist/NumDiscreteEditor-J2U7HNKJ.js +165 -0
- package/dist/NumDiscreteEditor.unit.spec-4GJMCLZB.js +229 -0
- package/dist/NumRegularBinEditor-R7KDRY3C.js +29 -0
- package/dist/NumRegularBinEditor.unit.spec-7QORM76Z.js +274 -0
- package/dist/NumSplineEditor-TY7QSYBC.js +205 -0
- package/dist/NumSplineEditor.unit.spec-NRP4XDUK.js +220 -0
- package/dist/NumericDensity-X3WDJHHT.js +29 -0
- package/dist/NumericDensity.unit.spec-LPW5M4MB.js +414 -0
- package/dist/NumericHandler-E7H7WJHR.js +30 -0
- package/dist/NumericHandler.unit.spec-FE2LOGCS.js +225 -0
- package/dist/ProteomeInput-4M2SXSJG.js +610 -0
- package/dist/Regression-GXAACUGA.js +1412 -0
- package/dist/RunChart2-ZE7RGJEJ.js +744 -0
- package/dist/SC-4O73EKKZ.js +1290 -0
- package/dist/Violin-AR74D2S5.js +1092 -0
- package/dist/Volcano-NC6CM3FY.js +2657 -0
- package/dist/Volcano-NC6CM3FY.js.map +7 -0
- package/dist/Wsi-AR2WRIQO.js +636 -0
- package/dist/aboutSunburst-3KM2UULF.js +93 -0
- package/dist/adSandbox-WJ4KBWMU.js +29 -0
- package/dist/animatedBubbleChart-ASVK3MS5.js +542 -0
- package/dist/app-V2TCAQ4U.js +28 -0
- package/dist/app-X4AN7T54.js +38 -0
- package/dist/app.js +10 -10
- package/dist/bam-5PYKCF2J.js +872 -0
- package/dist/barchart-CM3XHZTA.js +38 -0
- package/dist/barchart2-SC63JKN5.js +305 -0
- package/dist/block-LYSTIZKO.js +6203 -0
- package/dist/block.init-PCK3GPSX.js +29 -0
- package/dist/block.mds.expressionrank-C66QPAGB.js +350 -0
- package/dist/block.mds.geneboxplot-MNER4EZ5.js +819 -0
- package/dist/block.mds.junction-2R4UBHO7.js +1534 -0
- package/dist/block.mds.svcnv-FHGLK36W.js +6325 -0
- package/dist/block.svg-CNO5DO4Y.js +155 -0
- package/dist/block.tk.aicheck-6A3JDKF2.js +274 -0
- package/dist/block.tk.bam-RBTLQF4P.js +1906 -0
- package/dist/block.tk.bigwig.ui-E7KNTBTB.js +202 -0
- package/dist/block.tk.hicstraw-C6FTURLI.js +814 -0
- package/dist/block.tk.junction-B4ZMCASB.js +2353 -0
- package/dist/block.tk.junction.textmatrixui-OAQVVD7S.js +190 -0
- package/dist/block.tk.ld-QFZA5KX3.js +90 -0
- package/dist/block.tk.menu-XORKRT37.js +1050 -0
- package/dist/block.tk.pgv-WI7IV5X2.js +934 -0
- package/dist/brainImaging-WNEQQ3RS.js +550 -0
- package/dist/brainRegions-WKCAU4NE.js +213 -0
- package/dist/bubbleHeatmap-CYHNKNYP.js +374 -0
- package/dist/cellTypeBubbleHeatmap-N6JWAUWC.js +274 -0
- package/dist/chunk-2GWAEK4R.js +276 -0
- package/dist/chunk-2Q3ETPV2.js +296 -0
- package/dist/chunk-3FRAKLFY.js +2102 -0
- package/dist/chunk-4XFL2PXO.js +257 -0
- package/dist/chunk-5MBKRZWI.js +96 -0
- package/dist/chunk-5NQXKUJ3.js +243 -0
- package/dist/chunk-5WZ3ZWZC.js +6375 -0
- package/dist/chunk-64RXHMGN.js +2922 -0
- package/dist/chunk-64RXHMGN.js.map +7 -0
- package/dist/chunk-6PBTY7CY.js +255 -0
- package/dist/chunk-7T42GBVS.js +379 -0
- package/dist/chunk-7WGPCIRT.js +2685 -0
- package/dist/chunk-CCCJPKPR.js +652 -0
- package/dist/chunk-CIF2HSFF.js +848 -0
- package/dist/chunk-CLCHYFFY.js +82 -0
- package/dist/chunk-CMLHNNB2.js +1339 -0
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- package/dist/chunk-GSKQNIHP.js +626 -0
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- package/dist/chunk-LOCZDGJO.js +480 -0
- package/dist/chunk-LP54W3BC.js +56 -0
- package/dist/chunk-M7L34WTV.js +240 -0
- package/dist/chunk-MPYLBO7E.js +54 -0
- package/dist/chunk-MVZWVLLA.js +1253 -0
- package/dist/chunk-N3XBGDFY.js +159 -0
- package/dist/chunk-NYJR4ELG.js +4389 -0
- package/dist/chunk-O3XTTT4K.js +217 -0
- package/dist/chunk-OJH2LKPN.js +299 -0
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- package/dist/chunk-RQPXQOAX.js +692 -0
- package/dist/chunk-RXJTJDPZ.js +54 -0
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- package/dist/chunk-SAYYZU35.js +5214 -0
- package/dist/chunk-SMVZ6AN5.js +123 -0
- package/dist/chunk-T3VFO5NA.js +550 -0
- package/dist/chunk-U45YALDI.js +26716 -0
- package/dist/chunk-U45YALDI.js.map +7 -0
- package/dist/chunk-UP2ZRNZD.js +340 -0
- package/dist/chunk-VBRCIPFK.js +182 -0
- package/dist/chunk-VDXHBYZS.js +35 -0
- package/dist/chunk-VFLGHCUO.js +194 -0
- package/dist/chunk-VJALVBYH.js +102 -0
- package/dist/chunk-W3DJIU4H.js +102 -0
- package/dist/chunk-W46Q37IZ.js +141 -0
- package/dist/chunk-WHF2BXCF.js +56 -0
- package/dist/chunk-XAA5QWS3.js +466 -0
- package/dist/chunk-XF67G5YB.js +237 -0
- package/dist/chunk-XPQV3UZJ.js +176 -0
- package/dist/chunk-Y3GKZVCQ.js +468 -0
- package/dist/cohort-XASFFGZP.js +66 -0
- package/dist/cohortSunburst-HEXOA7M4.js +402 -0
- package/dist/condition-ZDF5SRLZ.js +323 -0
- package/dist/controls-Z4URI2HB.js +30 -0
- package/dist/controls.config-353QCQTZ.js +30 -0
- package/dist/correlation-4LIZRR2U.js +91 -0
- package/dist/customdata.inputui-AECESQA6.js +280 -0
- package/dist/dataDownload-LJPBW5RL.js +326 -0
- package/dist/databrowser.ui-IJ75U47I.js +421 -0
- package/dist/dictionary-S4MSWVZV.js +109 -0
- package/dist/dnaMethylation-QMKO3DXK.js +29 -0
- package/dist/dnaMethylation.integration.spec-XGMDB2IK.js +194 -0
- package/dist/dofetch-4P5F5ZGU.js +49 -0
- package/dist/e2pca-TS6JJLVI.js +340 -0
- package/dist/ep-S76L4MUE.js +1247 -0
- package/dist/expclust.gdc.spec-S75GMZYG.js +298 -0
- package/dist/facet-YFLHDE77.js +556 -0
- package/dist/gb-KP2WZN6P.js +77 -0
- package/dist/geneExpClustering-QTUBMZ6X.js +240 -0
- package/dist/geneExpression-6JNMJMWW.js +309 -0
- package/dist/geneExpression-JVVUKN4A.js +29 -0
- package/dist/geneExpression.unit.spec-2SANMIWR.js +151 -0
- package/dist/geneORA-NWJCROO7.js +269 -0
- package/dist/geneRanking-K6E7MT33.js +544 -0
- package/dist/geneVariant-3KV4PCMU.js +289 -0
- package/dist/geneVariant-FICL4MXY.js +32 -0
- package/dist/geneVariant.integration.spec-ANHTHANE.js +672 -0
- package/dist/genefusion.ui-3RYS5UPO.js +299 -0
- package/dist/geneset-UODQ45RY.js +199 -0
- package/dist/genomeBrowser.spec-6YCQISMJ.js +272 -0
- package/dist/grin2-WN32DXUL.js +945 -0
- package/dist/grin2-ZLU7NL6L.js +66 -0
- package/dist/hierCluster-36UVKTYM.js +51 -0
- package/dist/hierCluster-W5GMLGYX.js +55 -0
- package/dist/hierCluster.config-R5TSOJXJ.js +32 -0
- package/dist/hierCluster.integration.spec-DWKVGISB.js +479 -0
- package/dist/hierCluster.interactivity-5EFMAIWI.js +45 -0
- package/dist/imagePlot-BJAQGEBF.js +152 -0
- package/dist/importPlot-CEK76RBM.js +8 -0
- package/dist/isoformExpression-QOJ5RAB6.js +31 -0
- package/dist/isoformExpression.unit.spec-73Z5IT2B.js +233 -0
- package/dist/junction-6GSHMBTA.js +32 -0
- package/dist/junction.unit.spec-N45VJHZC.js +178 -0
- package/dist/launch.adhoc-QTDSBMG2.js +33 -0
- package/dist/leftlabel.sample-4ZY2RAXT.js +253 -0
- package/dist/lollipop-TNBUY55O.js +162 -0
- package/dist/maf-O5DQLUM6.js +451 -0
- package/dist/maftimeline-77RLW7FI.js +583 -0
- package/dist/matrix-KWYUKXMK.js +55 -0
- package/dist/matrix-TFFEEDIA.js +50 -0
- package/dist/matrix.config-RO3SVOXR.js +33 -0
- package/dist/matrix.integration.spec-SVRHEE3X.js +3156 -0
- package/dist/matrix.interactivity-IFAZAA5Z.js +33 -0
- package/dist/matrix.layout-YBOMANSO.js +35 -0
- package/dist/matrix.renderers-GMFIA6FN.js +30 -0
- package/dist/matrix.sort.unit.spec-OTC5SKDW.js +464 -0
- package/dist/matrix.sorterUi.unit.spec-2AJSZUK3.js +334 -0
- package/dist/matrix.unit.spec-BHFL7H6D.js +146 -0
- package/dist/mavb-6SHMALCY.js +726 -0
- package/dist/mds.samplescatterplot-3JODEENU.js +1545 -0
- package/dist/mds.survivalplot-ULRIJGIS.js +472 -0
- package/dist/multivalue-G2AILJHU.js +79 -0
- package/dist/oncomatrix-X5BFAMYH.js +286 -0
- package/dist/oncomatrix.spec-MLIE6VVA.js +439 -0
- package/dist/plot.2dvaf-FG3LJGP5.js +368 -0
- package/dist/plot.app-VLWWYTVJ.js +32 -0
- package/dist/plot.barplot-CXO6EEMZ.js +93 -0
- package/dist/plot.boxplot-FOXP2N7H.js +142 -0
- package/dist/plot.brainImaging-Y36M3BBW.js +51 -0
- package/dist/plot.disco-YY3ITSSS.js +98 -0
- package/dist/plot.ssgq-3UGJTTCN.js +130 -0
- package/dist/plot.vaf2cov-4FD5IA7A.js +249 -0
- package/dist/polar2-VK4MADEW.js +228 -0
- package/dist/profileForms-53MNCKET.js +937 -0
- package/dist/profilePlot-SPLM6VD4.js +45 -0
- package/dist/proteinView-ZHNMVSLF.js +1346 -0
- package/dist/proteomeCohortCompare-WGUPOLE3.js +866 -0
- package/dist/pseudbulk.unit.spec-Y4CRM6VQ.js +82 -0
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- package/dist/render-O244ZE5A.js +29 -0
- package/dist/report-47ASX5AT.js +213 -0
- package/dist/sampleView-SS5PCWRL.js +39 -0
- package/dist/samplelst-CZV77Z7N.js +114 -0
- package/dist/samplematrix-TXGERKS2.js +2188 -0
- package/dist/sc-XN44V5EK.js +77 -0
- package/dist/scatter-4B7LPX6B.js +84 -0
- package/dist/scatter-DXGINZED.js +919 -0
- package/dist/selectGenomeWithTklst-YQMYWVXF.js +125 -0
- package/dist/singleCellCellType-AJEAQL4Y.js +29 -0
- package/dist/singleCellCellType.unit.spec-7YCO4VV7.js +150 -0
- package/dist/singleCellGeneExpression-LPDACSPJ.js +29 -0
- package/dist/singleCellGeneExpression.unit.spec-JZHG5OAH.js +144 -0
- package/dist/singleCellNumericValue-SDUSPCBR.js +29 -0
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- package/dist/singleCellPlot-5AAE5QGD.js +44 -0
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- package/dist/studyCatalog-TOGQ24WQ.js +457 -0
- package/dist/summarizeCnvGeneexp-6Z3VVSMQ.js +154 -0
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- package/dist/summarizeMutationDiagnosis-PVOTM3DF.js +31 -0
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- package/dist/summary-RNNIEEHQ.js +40 -0
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- package/dist/sunburst-MYKDYBVD.js +34 -0
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- /package/dist/{tk-UHDGIDTK.js.map → tk-7OE7QMYG.js.map} +0 -0
- /package/dist/{tk-JBLKYKKI.js.map → tk-R6IBTAYE.js.map} +0 -0
- /package/dist/{tp.ui-X2BJWXKN.js.map → tp.ui-BGSBCIR7.js.map} +0 -0
- /package/dist/{tvs.categorical-ZTFJDJQU.js.map → tvs.categorical-RTSI5L6T.js.map} +0 -0
- /package/dist/{tvs.condition-DCDNI627.js.map → tvs.condition-VBDUN33K.js.map} +0 -0
- /package/dist/{tvs.dt-X6DES76X.js.map → tvs.dt-NP6556P7.js.map} +0 -0
- /package/dist/{tvs.dtcnv.categorical-UPRTUO7A.js.map → tvs.dtcnv.categorical-RERJRI5J.js.map} +0 -0
- /package/dist/{tvs.dtcnv.continuous-K3J5KKZD.js.map → tvs.dtcnv.continuous-UEVWYT3H.js.map} +0 -0
- /package/dist/{tvs.dtfusion-XV3UM2QG.js.map → tvs.dtfusion-CRJ77JUK.js.map} +0 -0
- /package/dist/{tvs.dtitd-LKYJG4XK.js.map → tvs.dtitd-ZOCNVICE.js.map} +0 -0
- /package/dist/{tvs.dtsnvindel-KFAQGI4H.js.map → tvs.dtsnvindel-LFWG54AQ.js.map} +0 -0
- /package/dist/{tvs.dtsv-4NV4DRWC.js.map → tvs.dtsv-SNIZC3C6.js.map} +0 -0
- /package/dist/{tvs.multivalue-WSSBQ7K4.js.map → tvs.multivalue-UJS4743S.js.map} +0 -0
- /package/dist/{tvs.numeric-OFA6L2TA.js.map → tvs.numeric-KKMUTKSJ.js.map} +0 -0
- /package/dist/{tvs.samplelst-W6QKXHGF.js.map → tvs.samplelst-AW3IY3CB.js.map} +0 -0
- /package/dist/{tvs.survival-ESWYE4QM.js.map → tvs.survival-LH2Z3WTM.js.map} +0 -0
- /package/dist/{tvs.termCollection-3GOKKMKB.js.map → tvs.termCollection-OQNMYVX5.js.map} +0 -0
- /package/dist/{vocabulary-6S6F2UAA.js.map → vocabulary-6XMG22NZ.js.map} +0 -0
- /package/dist/{wsi.direct-ZAOVMG5X.js.map → wsi.direct-EJ2ENH64.js.map} +0 -0
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getFilterName,
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makelabel,
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printCategory,
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rangequery_rglst,
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setLeftlabelsMaxWidth
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axisstyle,
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table2col
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simulation_default,
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y_default
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// j2/legend.js
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function initLegend(tk, block) {
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if (!block.legend) return;
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if (!tk.legend) tk.legend = {};
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tk.legend.tip = new Menu({ padding: "0px" });
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const [tr, td, td0] = legend_newrow(block, tk.custom_data ? tk.name : tk.dslabel);
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tk.legend.headTd = td0;
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tk.tr_legend = tr;
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const table = td.append("table").style("border-spacing", "5px").style("border-collapse", "separate");
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tk.legend.table = table;
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create_type(tk, block);
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update_type(tk);
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function create_type(tk, block) {
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if (!tk.legend.type.hiddenvalues) tk.legend.type.hiddenvalues = /* @__PURE__ */ new Set();
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if (tk.hiddentypes) {
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for (const c of tk.hiddentypes.split(",")) tk.legend.type.hiddenvalues.add(c);
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}
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tk.legend.type.row = tk.legend.table.append("tr");
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tk.legend.type.row.append("td").attr("data-testid", "sjpp-j2-legend-row-type").style("text-align", "right").style("opacity", 0.7).text(tk.deltaPsiGroups ? "PSI" : "Type");
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tk.legend.type.holder = tk.legend.type.row.append("td");
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function update_type(tk) {
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const type2count = /* @__PURE__ */ new Map();
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for (const j of tk.data) {
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}
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label: JTypes[t].name,
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color: JTypes[t].color,
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count: c,
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testid: "sjpp-j2-legend-row-type-item",
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click: (event) => {
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const opts = [
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{
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label: "Hide",
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callback: () => {
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tk.legend.type.hiddenvalues.add(t);
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}
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},
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{
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label: "Show only",
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callback: () => {
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for (const t2 of type2count.keys()) {
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tk.legend.type.hiddenvalues.add(t2);
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}
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tk.legend.type.hiddenvalues.delete(t);
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}
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},
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{
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label: "Show all",
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isVisible: () => tk.legend.type.hiddenvalues.size,
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callback: () => {
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}
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}
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];
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tk.legend.tip.clear().showunder(event.target);
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for (const o of opts) {
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if (o.isVisible && o.isVisible() == false) continue;
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tk.legend.tip.d.append("div").attr("class", "sja_menuoption").attr("data-testid", `sjpp-legend-option-${o.label.toLowerCase().replace(/\s/g, "-")}`).style("border-radius", "0px").text(o.label).on("click", () => {
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o.callback();
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tk.legend.tip.hide();
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tk.load();
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});
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}
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}
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});
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}
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for (const c of tk.legend.type.hiddenvalues) {
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let loading = false;
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tk.legend.type.holder.append("div").style("display", "inline-block").attr("class", "sja_clb").style("text-decoration", "line-through").style("opacity", 0.7).text(JTypes[c].name).on("click", async (event) => {
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if (loading) return;
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loading = true;
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tk.legend.type.hiddenvalues.delete(c);
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event.target.innerHTML = "Updating...";
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await tk.load();
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});
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}
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}
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function update_deltaPsi(tk) {
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tk.legend.type.holder.selectAll("*").remove();
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const { case: _case, control } = tk.deltaPsiGroups;
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const categories = [
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{ key: "case", label: `${_case.name} > ${control.name}`, color: _case.color },
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{ key: "control", label: `${control.name} > ${_case.name}`, color: control.color },
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{ key: void 0, label: "Equal or missing", color: "#858585" }
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];
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for (const c of categories) {
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const count = tk.data.filter((j) => j.higherPsiIn == c.key).length;
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if (!count && !c.key) continue;
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printCategory({
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holder: tk.legend.type.holder,
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key: c.key || "none",
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label: c.label,
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color: c.color,
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count,
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testid: "sjpp-j2-legend-row-type-item"
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});
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}
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186
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}
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// j2/render.js
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189
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var minfontsize = 12;
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190
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var lineopacity = 0.5;
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191
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var discopacity = 0.5;
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function renderTk(data, tk, block) {
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if (data) {
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tk.sections.jug.yAxisKey = tk.custom_data && data.junctions.every((j) => Number.isFinite(j.negLog10p)) ? "negLog10p" : !tk.custom_data || Number.isFinite(data.maxReadCount) ? "medianReadCount" : void 0;
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if (data.junctions?.length == 0) {
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tk.data = [];
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tk.leftlabels?.doms?.jug?.text("0 junctions");
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return;
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}
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if (tk.sections.jug.yAxisKey == "medianReadCount" && !Number.isFinite(data.maxReadCount))
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throw new Error("data.maxReadCount is not number");
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tk.maxReadCount = data.maxReadCount;
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if (rawdata2track(data.junctions, tk, block)) {
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tk.data = [];
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data.junctions = [];
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tk.leftlabels.doms.jug.text("0 junctions");
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return;
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}
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} else {
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}
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211
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tk.leftlabels.doms.jug.text(`${tk.data.length} junction${tk.data.length > 1 ? "s" : ""}`);
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const viewpxwidth = block.width + block.subpanels.reduce((i, j) => i + j.leftpad + j.width, 0);
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setColor(tk);
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tk.sections.jug.g.selectAll("*").remove();
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const mg = tk.sections.jug.g;
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216
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tk.data.sort((a, b) => {
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return a._x - b._x;
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});
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{
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const maxsamplecount = tk.data.reduce((max, j) => Math.max(max, j.sampleCount ?? 1), 0);
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const radius = 5;
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222
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let mrd = 0;
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223
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const w = Math.pow(radius, 2) * Math.PI;
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224
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if (maxsamplecount <= 10) {
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225
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mrd = w * maxsamplecount * 0.9;
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} else if (maxsamplecount <= 100) {
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mrd = w * 10;
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} else if (maxsamplecount <= 1e3) {
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mrd = w * 14;
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} else {
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mrd = w * 20;
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}
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const sf_discradius = linear().domain([
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1,
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maxsamplecount * 0.5 + 0.1,
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maxsamplecount * 0.6 + 0.1,
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maxsamplecount * 0.7 + 0.1,
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maxsamplecount * 0.8 + 0.1,
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maxsamplecount
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]).range([w, w + (mrd - w) * 0.8, w + (mrd - w) * 0.85, w + (mrd - w) * 0.9, w + (mrd - w) * 0.95, mrd]);
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let maxradius = 0;
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242
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for (const j of tk.data) {
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j.radius = Math.sqrt(sf_discradius(j.sampleCount ?? 1) / Math.PI);
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if (j.sampleCount > 1) {
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mg.append("text").attr("font-family", "Arial").attr("font-size", Math.max(minfontsize, j.radius)).text(j.sampleCount).each(function() {
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246
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const b = this.getBBox();
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const newrad = Math.sqrt(Math.pow(b.width, 2) + Math.pow(b.height, 2)) / 2;
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j.radius = Math.max(j.radius, newrad);
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}).remove();
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}
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j.rimwidth = j.rimcount ? Math.max(2, j.radius / 6) : 0;
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j.radius2 = j.radius + j.rimwidth + (j.rimwidth > 0 ? 1 : 0);
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maxradius = Math.max(maxradius, j.radius2);
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}
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tk.maxradius = maxradius;
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256
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}
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const maxmedian = tk.data.reduce((c, j) => Math.max(c, j.medianReadCount), 0);
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258
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tk.sections.jug.yscale = tk.sections.jug.yAxisKey == "medianReadCount" ? (tk.yscaleUseLog ? log() : linear()).domain([tk.readcountCutoff || 1, tk.maxReadCount]).range([tk.sections.jug.axisheight, 0]) : linear().domain([0, Math.max(1, ...tk.data.map((j) => yValue(j, tk)))]).nice().range([tk.sections.jug.axisheight, 0]);
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for (const j of tk.data) {
|
|
260
|
+
if (j.axisy == void 0) {
|
|
261
|
+
j.axisy = tk.sections.jug.axisheight - tk.sections.jug.yscale(yValue(j, tk));
|
|
262
|
+
}
|
|
263
|
+
}
|
|
264
|
+
tk.sections.jug.height = tk.sections.jug.axisheight + tk.sections.jug.neckheight + tk.sections.jug.legheight;
|
|
265
|
+
mg.attr("transform", `translate(0,${tk.sections.jug.height})`);
|
|
266
|
+
{
|
|
267
|
+
const topy = -tk.sections.jug.legheight - tk.sections.jug.neckheight - tk.sections.jug.axisheight;
|
|
268
|
+
mg.append("line").attr("x1", 0).attr("y1", topy).attr("y2", topy).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("shape-rendering", "crispEdges");
|
|
269
|
+
mg.append("line").attr("x1", 0).attr("y1", topy + tk.sections.jug.axisheight).attr("y2", topy + tk.sections.jug.axisheight).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("shape-rendering", "crispEdges");
|
|
270
|
+
let v = 10;
|
|
271
|
+
while (tk.sections.jug.yAxisKey == "medianReadCount" && v <= tk.maxReadCount) {
|
|
272
|
+
mg.append("line").attr("x1", 0).attr("y1", topy + tk.sections.jug.yscale(v)).attr("y2", topy + tk.sections.jug.yscale(v)).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("stroke-dasharray", "4,4").attr("shape-rendering", "crispEdges");
|
|
273
|
+
v *= 10;
|
|
274
|
+
}
|
|
275
|
+
}
|
|
276
|
+
const jug = mg.selectAll().data(tk.data).enter().append("g").attr("class", "sja_jug").attr("transform", (d) => set_jug(d)).each(function(j) {
|
|
277
|
+
j.jugg = this;
|
|
278
|
+
});
|
|
279
|
+
jug.append("line").attr("stroke", (d) => d.color).attr("x1", (d) => set_leg_x1(d)).attr("y2", -tk.sections.jug.legheight).attr("stroke-opacity", lineopacity).attr("class", "sja_jug_leg1").each(function(d) {
|
|
280
|
+
d.leg1 = this;
|
|
281
|
+
});
|
|
282
|
+
jug.append("line").attr("stroke", (d) => d.color).attr("x2", (d) => set_leg_x2(d)).attr("y1", -tk.sections.jug.legheight).attr("stroke-opacity", lineopacity).attr("class", "sja_jug_leg2").each(function(d) {
|
|
283
|
+
d.leg2 = this;
|
|
284
|
+
});
|
|
285
|
+
const jug2 = jug.append("g").attr("class", "sja_jug_jug2").attr("transform", (d) => set_jug2(d, tk));
|
|
286
|
+
jug2.append("line").attr("stroke", (d) => d.color).attr("class", "sja_jug_stem").attr("stroke-dasharray", "2,2").attr("shape-rendering", "crispEdges").attr("y1", (d) => d.radius).attr("y2", (d) => {
|
|
287
|
+
return tk.sections.jug.neckheight + d.axisy;
|
|
288
|
+
}).attr("stroke-opacity", lineopacity).each(function(d) {
|
|
289
|
+
d.stem = this;
|
|
290
|
+
});
|
|
291
|
+
jug2.append("circle").each(function(d) {
|
|
292
|
+
d.disc = this;
|
|
293
|
+
}).attr("r", (d) => d.radius).attr("fill", (d) => d.color).attr("stroke", "white").attr("fill-opacity", discopacity);
|
|
294
|
+
jug2.filter((d) => d.sampleCount > 1).append("text").text((d) => d.sampleCount).attr("font-size", (d) => Math.max(minfontsize, d.radius)).attr("class", "sja_jug_discnum").attr("fill", "white").attr("font-family", "Arial").attr("text-anchor", "middle").attr("dominant-baseline", "central");
|
|
295
|
+
jug2.append("circle").attr("r", (d) => d.radius).attr("stroke", (d) => d.color).attr("fill", "white").attr("fill-opacity", 0).attr("stroke-opacity", 0).on("mouseover", (event, d) => {
|
|
296
|
+
event.stopPropagation();
|
|
297
|
+
select_default(d.disc).attr("fill-opacity", 0.8);
|
|
298
|
+
select_default(d.stem).attr("stroke-opacity", 1);
|
|
299
|
+
select_default(d.leg1).attr("stroke-opacity", 1);
|
|
300
|
+
select_default(d.leg2).attr("stroke-opacity", 1);
|
|
301
|
+
mouseoverSpanBackground(d, tk, block, viewpxwidth);
|
|
302
|
+
mouseoverBoxplot(d, tk);
|
|
303
|
+
const p = event.target.getBoundingClientRect();
|
|
304
|
+
tk.hovertip.clear().show(p.left + p.width, p.top - 50);
|
|
305
|
+
showOneJunction(d, tk, tk.hovertip.d, block);
|
|
306
|
+
}).on("mouseout", (event, d) => {
|
|
307
|
+
tk.hovertip.hide();
|
|
308
|
+
tk.pica.g.selectAll("*").remove();
|
|
309
|
+
block.cursorhlbar.attr("fill", block.cursorhlbarFillColor);
|
|
310
|
+
select_default(d.disc).attr("fill-opacity", discopacity);
|
|
311
|
+
select_default(d.stem).attr("stroke-opacity", lineopacity);
|
|
312
|
+
select_default(d.leg1).attr("stroke-opacity", lineopacity);
|
|
313
|
+
select_default(d.leg2).attr("stroke-opacity", lineopacity);
|
|
314
|
+
}).on("mousedown", (event) => {
|
|
315
|
+
event.stopPropagation();
|
|
316
|
+
}).on("mousemove", (event) => {
|
|
317
|
+
event.stopPropagation();
|
|
318
|
+
}).on("click", (event, d) => {
|
|
319
|
+
tk.hovertip.hide();
|
|
320
|
+
const p = event.target.getBoundingClientRect();
|
|
321
|
+
tk.itemtip.clear().show(p.left + p.width, p.top - 50);
|
|
322
|
+
showOneJunction(d, tk, tk.itemtip.d.append("div"), block, true);
|
|
323
|
+
});
|
|
324
|
+
doForceLayout(tk, block, viewpxwidth).then(() => {
|
|
325
|
+
set_all(tk);
|
|
326
|
+
axisstyle({
|
|
327
|
+
axis: tk.sections.jug.axis.transition().call(
|
|
328
|
+
axisRight().scale(tk.sections.jug.yscale).ticks(
|
|
329
|
+
tk.sections.jug.yAxisKey ? Math.floor(tk.sections.jug.axisheight / 20) : 0,
|
|
330
|
+
tk.sections.jug.yAxisKey == "medianReadCount" ? ".0f" : void 0
|
|
331
|
+
)
|
|
332
|
+
),
|
|
333
|
+
color: "black",
|
|
334
|
+
showline: true
|
|
335
|
+
});
|
|
336
|
+
});
|
|
337
|
+
}
|
|
338
|
+
function rawdata2track(raw, tk, block) {
|
|
339
|
+
const viewpxwidth = block.width + block.subpanels.reduce((i, j) => i + j.leftpad + j.width, 0);
|
|
340
|
+
const junctions = [];
|
|
341
|
+
for (const j of raw) {
|
|
342
|
+
if (j.sv && j.chr == j.sv.mate.chr) {
|
|
343
|
+
if (j.start > j.sv.mate.start) {
|
|
344
|
+
const p = j.start;
|
|
345
|
+
j.start = j.stop = j.sv.mate.start;
|
|
346
|
+
j.sv.mate.start = j.sv.mate.stop = p;
|
|
347
|
+
const q = j.strand;
|
|
348
|
+
j.strand = j.sv.mate.strand;
|
|
349
|
+
j.sv.mate.strand = q;
|
|
350
|
+
}
|
|
351
|
+
}
|
|
352
|
+
const e = j2block(j, block, viewpxwidth);
|
|
353
|
+
if (e) {
|
|
354
|
+
console.log(
|
|
355
|
+
"junction not in view range: " + j.chr + ":" + j.start + "-" + (j.sv ? j.sv.mate.chr + ":" + j.sv.mate.start : j.stop)
|
|
356
|
+
);
|
|
357
|
+
continue;
|
|
358
|
+
}
|
|
359
|
+
junctions.push(j);
|
|
360
|
+
}
|
|
361
|
+
if (tk.data) {
|
|
362
|
+
const map = /* @__PURE__ */ new Map();
|
|
363
|
+
tk.data.forEach((j) => map.set(j.chr + "." + j.start + "." + j.stop + "." + j.strand, j));
|
|
364
|
+
const pannedpx = Number.isInteger(block.pannedpx) ? block.pannedpx : 0;
|
|
365
|
+
for (const i of junctions) {
|
|
366
|
+
const j = map.get(i.chr + "." + i.start + "." + i.stop + "." + i.strand);
|
|
367
|
+
if (j) {
|
|
368
|
+
i.x = j.x + pannedpx;
|
|
369
|
+
i.axisy = j.axisy;
|
|
370
|
+
}
|
|
371
|
+
}
|
|
372
|
+
}
|
|
373
|
+
if (junctions.length == 0) {
|
|
374
|
+
return "no junctions in view range";
|
|
375
|
+
}
|
|
376
|
+
tk.data = junctions;
|
|
377
|
+
}
|
|
378
|
+
function j2block(j, block, viewpxwidth) {
|
|
379
|
+
let starthit;
|
|
380
|
+
let stophit;
|
|
381
|
+
{
|
|
382
|
+
const l = block.seekcoord(j.chr, j.start);
|
|
383
|
+
for (const hit of l) {
|
|
384
|
+
if (hit.ridx != void 0 && block.subpanels) {
|
|
385
|
+
if (hit.x < 0 || hit.x > block.width) {
|
|
386
|
+
continue;
|
|
387
|
+
}
|
|
388
|
+
}
|
|
389
|
+
starthit = hit;
|
|
390
|
+
}
|
|
391
|
+
}
|
|
392
|
+
{
|
|
393
|
+
const l = block.seekcoord(j.sv ? j.sv.mate.chr : j.chr, j.sv ? j.sv.mate.start : j.stop);
|
|
394
|
+
for (const hit of l) {
|
|
395
|
+
if (hit.ridx != void 0 && block.subpanels) {
|
|
396
|
+
if (hit.x < 0 || hit.x > block.width) {
|
|
397
|
+
continue;
|
|
398
|
+
}
|
|
399
|
+
}
|
|
400
|
+
stophit = hit;
|
|
401
|
+
}
|
|
402
|
+
}
|
|
403
|
+
if (starthit) {
|
|
404
|
+
if (!stophit) {
|
|
405
|
+
stophit = starthit;
|
|
406
|
+
}
|
|
407
|
+
} else {
|
|
408
|
+
if (stophit) {
|
|
409
|
+
starthit = stophit;
|
|
410
|
+
} else {
|
|
411
|
+
return true;
|
|
412
|
+
}
|
|
413
|
+
}
|
|
414
|
+
let startout = starthit.x < 0 || starthit.x > viewpxwidth;
|
|
415
|
+
let stopout = stophit.x < 0 || stophit.x > viewpxwidth;
|
|
416
|
+
if (startout && stopout) {
|
|
417
|
+
return true;
|
|
418
|
+
}
|
|
419
|
+
j.x0 = starthit.x;
|
|
420
|
+
j.x1 = stophit.x;
|
|
421
|
+
j.x = (j.x0 + j.x1) / 2;
|
|
422
|
+
j._x = j.x;
|
|
423
|
+
return false;
|
|
424
|
+
}
|
|
425
|
+
function yValue(j, tk) {
|
|
426
|
+
return tk.sections.jug.yAxisKey ? j[tk.sections.jug.yAxisKey] : 0;
|
|
427
|
+
}
|
|
428
|
+
function setColor(tk) {
|
|
429
|
+
for (const j of tk.data) {
|
|
430
|
+
delete j.color;
|
|
431
|
+
const d = tk.deltaPsiGroups && j.psi_case != null && j.psi_control != null ? j.psi_case - j.psi_control : 0;
|
|
432
|
+
j.higherPsiIn = d > 0 ? "case" : d < 0 ? "control" : void 0;
|
|
433
|
+
if (j.higherPsiIn) {
|
|
434
|
+
j.color = tk.deltaPsiGroups[j.higherPsiIn].color;
|
|
435
|
+
} else if (tk.deltaPsiGroups || tk.custom_data && !j.types.length) {
|
|
436
|
+
j.color = "#858585";
|
|
437
|
+
} else {
|
|
438
|
+
j.color = JTypes[j.types[0]]?.color;
|
|
439
|
+
if (j.color == void 0) throw new Error("unknown j.type");
|
|
440
|
+
}
|
|
441
|
+
}
|
|
442
|
+
}
|
|
443
|
+
function set_jug(d) {
|
|
444
|
+
return "translate(" + d.x + ",0)";
|
|
445
|
+
}
|
|
446
|
+
function set_leg_x1(d) {
|
|
447
|
+
return d.x0 - d.x;
|
|
448
|
+
}
|
|
449
|
+
function set_leg_x2(d) {
|
|
450
|
+
return d.x1 - d.x;
|
|
451
|
+
}
|
|
452
|
+
function set_jug2(d, tk) {
|
|
453
|
+
return "translate(0,-" + (tk.sections.jug.legheight + tk.sections.jug.neckheight + d.axisy) + ")";
|
|
454
|
+
}
|
|
455
|
+
function set_all(tk) {
|
|
456
|
+
const mg = tk.sections.jug;
|
|
457
|
+
tk.data.forEach((j) => j.axisy = mg.axisheight - mg.yscale(yValue(j, tk)));
|
|
458
|
+
const dur = 500;
|
|
459
|
+
mg.g.selectAll(".sja_jug_leg1").transition().duration(dur).attr("y2", -mg.legheight).attr("x1", (d) => set_leg_x1(d));
|
|
460
|
+
mg.g.selectAll(".sja_jug_leg2").transition().duration(dur).attr("y1", -mg.legheight).attr("x2", (d) => set_leg_x2(d));
|
|
461
|
+
mg.g.selectAll(".sja_jug_jug2").transition().duration(dur).attr("transform", (d) => set_jug2(d, tk));
|
|
462
|
+
mg.g.selectAll(".sja_jug").transition().duration(dur).attr("transform", (d) => set_jug(d));
|
|
463
|
+
mg.g.selectAll(".sja_jug_stem").transition().duration(dur).attr("y2", (d) => mg.neckheight + d.axisy);
|
|
464
|
+
}
|
|
465
|
+
function doForceLayout(tk, block, viewpxwidth) {
|
|
466
|
+
const nodes = [];
|
|
467
|
+
let sumdiscwidth = 0;
|
|
468
|
+
tk.data.map((j) => {
|
|
469
|
+
let tox;
|
|
470
|
+
if (j.x0 < 0) {
|
|
471
|
+
tox = j.x1 - j.radius2 * 2;
|
|
472
|
+
} else if (j.x1 > viewpxwidth) {
|
|
473
|
+
tox = j.x0 + j.radius2 * 2;
|
|
474
|
+
} else {
|
|
475
|
+
tox = j._x;
|
|
476
|
+
}
|
|
477
|
+
nodes.push({
|
|
478
|
+
junction: j,
|
|
479
|
+
tox,
|
|
480
|
+
x: tox,
|
|
481
|
+
y: tk.sections.jug.axisheight - tk.sections.jug.yscale(yValue(j, tk))
|
|
482
|
+
});
|
|
483
|
+
sumdiscwidth += j.radius2 * 2;
|
|
484
|
+
});
|
|
485
|
+
nodes.sort((i, j) => i.tox - j.tox);
|
|
486
|
+
nodes.forEach((n, i) => n.index = i);
|
|
487
|
+
const collidestrength = sumdiscwidth <= viewpxwidth ? 1 : viewpxwidth / sumdiscwidth;
|
|
488
|
+
return new Promise((resolve, reject) => {
|
|
489
|
+
simulation_default(nodes).force(
|
|
490
|
+
"y",
|
|
491
|
+
y_default((d) => {
|
|
492
|
+
return tk.sections.jug.axisheight - tk.sections.jug.yscale(yValue(d.junction, tk));
|
|
493
|
+
}).strength(1)
|
|
494
|
+
).force("x", x_default((d) => d.tox).strength(0.1)).force(
|
|
495
|
+
"collide",
|
|
496
|
+
collide_default((d) => {
|
|
497
|
+
return d.junction.radius2 + 2;
|
|
498
|
+
}).strength(collidestrength)
|
|
499
|
+
).alphaMin(0.5).on("end", () => {
|
|
500
|
+
nodes.forEach((n) => {
|
|
501
|
+
n.junction.x = n.x;
|
|
502
|
+
});
|
|
503
|
+
resolve();
|
|
504
|
+
});
|
|
505
|
+
});
|
|
506
|
+
}
|
|
507
|
+
function mouseoverSpanBackground(j, tk, block, viewpxwidth) {
|
|
508
|
+
let xleft = Math.min(j.x0, j.x1);
|
|
509
|
+
let xright = Math.max(j.x0, j.x1);
|
|
510
|
+
if (block.usegm && block.usegm.strand == "-") {
|
|
511
|
+
xleft = j.x1;
|
|
512
|
+
xright = j.x0;
|
|
513
|
+
}
|
|
514
|
+
if (xleft >= 0 && xright <= viewpxwidth) {
|
|
515
|
+
block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xleft).attr("y", 0).attr("width", xright - xleft).attr("height", block.totalheight()).attr("fill", "url(#" + tk.gradient4spanBackground.mid.id + ")");
|
|
516
|
+
return;
|
|
517
|
+
}
|
|
518
|
+
const boxwidth = 50;
|
|
519
|
+
if (xleft >= 0) {
|
|
520
|
+
block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xleft).attr("fill", "url(#" + tk.gradient4spanBackground.left.id + ")");
|
|
521
|
+
} else {
|
|
522
|
+
block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xright - boxwidth).attr("fill", "url(#" + tk.gradient4spanBackground.right.id + ")");
|
|
523
|
+
}
|
|
524
|
+
block.cursorhlbar.attr("y", 0).attr("width", boxwidth).attr("height", block.totalheight());
|
|
525
|
+
}
|
|
526
|
+
function mouseoverBoxplot(j, tk) {
|
|
527
|
+
if (!j.readcountBoxplot) return;
|
|
528
|
+
const color = "black";
|
|
529
|
+
const p5 = tk.sections.jug.yscale(j.readcountBoxplot[0]);
|
|
530
|
+
const p25 = tk.sections.jug.yscale(j.readcountBoxplot[1]);
|
|
531
|
+
const p50 = tk.sections.jug.yscale(j.readcountBoxplot[2]);
|
|
532
|
+
const p75 = tk.sections.jug.yscale(j.readcountBoxplot[3]);
|
|
533
|
+
const p95 = tk.sections.jug.yscale(j.readcountBoxplot[4]);
|
|
534
|
+
const w = 10;
|
|
535
|
+
tk.pica.g.selectAll("*").remove();
|
|
536
|
+
tk.pica.g.attr("transform", "translate(" + j.x + "," + p50 + ")");
|
|
537
|
+
const g = tk.pica.g.append("g").attr("transform", "translate(" + (-5 - w - j.radius2) + ",0)");
|
|
538
|
+
g.append("line").attr("x1", w / 2).attr("x2", w / 2).attr("y1", p95 - p50).attr("y2", p5 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
|
|
539
|
+
g.append("line").attr("x1", 0).attr("x2", w).attr("y1", p5 - p50).attr("y2", p5 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
|
|
540
|
+
g.append("line").attr("x1", 0).attr("x2", w).attr("y1", p95 - p50).attr("y2", p95 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
|
|
541
|
+
g.append("rect").attr("y", p75 - p50).attr("width", w).attr("height", p25 - p75).attr("stroke", color).attr("fill", "white").attr("shape-rendering", "crispEdges");
|
|
542
|
+
if (p25 - p75 > 3) {
|
|
543
|
+
g.append("line").attr("x2", w).attr("stroke", color).attr("shape-rendering", "crispEdges");
|
|
544
|
+
}
|
|
545
|
+
}
|
|
546
|
+
function showOneJunction(j, tk, holder, block, isClickMenu = false) {
|
|
547
|
+
const table = table2col({ holder, margin: "0px" });
|
|
548
|
+
{
|
|
549
|
+
const [t1, t2] = table.addRow();
|
|
550
|
+
t1.text("Junction");
|
|
551
|
+
const div = t2.append("div");
|
|
552
|
+
if (!j.sv || j.chr == j.sv.mate.chr) {
|
|
553
|
+
div.html(
|
|
554
|
+
bplen(Math.abs(j.start - (j.sv ? j.sv.mate.start : j.stop))) + ' <span style="font-size:.8em;">' + j.chr + ":" + (j.start + 1) + "-" + ((j.sv ? j.sv.mate.start : j.stop) + 1) + "</span>"
|
|
555
|
+
);
|
|
556
|
+
} else {
|
|
557
|
+
div.html(
|
|
558
|
+
'<span style="font-size:.8em;">' + j.chr + ":" + (j.start + 1) + "-" + j.sv.mate.chr + ":" + (j.sv.mate.start + 1) + "</span>"
|
|
559
|
+
);
|
|
560
|
+
}
|
|
561
|
+
const d2 = t2.append("div");
|
|
562
|
+
if (j.strand) {
|
|
563
|
+
d2.append("span").attr("class", "sja_mcdot").style("padding", "1px 5px").style("background-color", "#555").style("margin-right", "5px").text(j.strand);
|
|
564
|
+
}
|
|
565
|
+
if (j.info.site) {
|
|
566
|
+
d2.append("span").style("font-size", ".7em").style("margin-right", "5px").text(j.info.site);
|
|
567
|
+
}
|
|
568
|
+
for (const t of j.types) {
|
|
569
|
+
d2.append("span").attr("class", "sja_mcdot").style("padding", "1px 5px").style("background-color", JTypes[t]?.color || "black").style("margin-right", "5px").text(JTypes[t]?.name || "?");
|
|
570
|
+
}
|
|
571
|
+
}
|
|
572
|
+
if (Number.isFinite(j.p)) table.addRow("p-value", roundValueAuto(j.p));
|
|
573
|
+
if ("psi_control" in j || "psi_case" in j) {
|
|
574
|
+
const psi = (v) => v == null ? "NA" : roundValueAuto(v);
|
|
575
|
+
table.addRow(`PSI, ${tk.deltaPsiGroups?.control.name || "control"}`, psi(j.psi_control));
|
|
576
|
+
table.addRow(`PSI, ${tk.deltaPsiGroups?.case.name || "case"}`, psi(j.psi_case));
|
|
577
|
+
if (j.psi_control != null && j.psi_case != null) table.addRow("\u0394PSI", roundValueAuto(j.psi_case - j.psi_control));
|
|
578
|
+
}
|
|
579
|
+
if (Number.isFinite(j.medianReadCount)) {
|
|
580
|
+
const [t1, t2] = table.addRow();
|
|
581
|
+
if (!(j.sampleCount > 1)) {
|
|
582
|
+
t1.text("Sample");
|
|
583
|
+
const sndiv = t2.append("div");
|
|
584
|
+
sndiv.text(j.sampleName || "single sample");
|
|
585
|
+
t2.append("div").html(j.medianReadCount + ' <span style="font-size:.7em">read count</span>');
|
|
586
|
+
} else {
|
|
587
|
+
t1.text("Samples");
|
|
588
|
+
t2.append("div").html(`${j.sampleCount} <span style="font-size:.7em">samples</span>
|
|
589
|
+
<br>${j.medianReadCount} <span style="font-size:.7em">median read count</span>`);
|
|
590
|
+
}
|
|
591
|
+
}
|
|
592
|
+
if (isClickMenu && tk.massApp) {
|
|
593
|
+
const [, buttonCell] = table.addRow();
|
|
594
|
+
buttonCell.append("button").attr("data-testid", "sjpp-junction-details").text("Details").on("click", async () => {
|
|
595
|
+
tk.itemtip.hide();
|
|
596
|
+
await tk.massApp.dispatch({
|
|
597
|
+
type: "plot_create",
|
|
598
|
+
config: {
|
|
599
|
+
chartType: "summary",
|
|
600
|
+
term: { term: makeJunctionTerm(j), q: { mode: "continuous" } }
|
|
601
|
+
}
|
|
602
|
+
});
|
|
603
|
+
});
|
|
604
|
+
buttonCell.append("button").attr("data-testid", "sjpp-junction-select").text("Select").on("click", async (event) => {
|
|
605
|
+
await addJunctionCustomTerm(tk, [makeJunctionTerm(j)], event.currentTarget, msgDiv);
|
|
606
|
+
});
|
|
607
|
+
const msgDiv = buttonCell.append("div").style("font-size", ".7em");
|
|
608
|
+
}
|
|
609
|
+
const type2elst = /* @__PURE__ */ new Map();
|
|
610
|
+
for (const e of j.info?.events || []) {
|
|
611
|
+
if (!type2elst.has(e.type)) type2elst.set(e.type, []);
|
|
612
|
+
type2elst.get(e.type).push(e);
|
|
613
|
+
}
|
|
614
|
+
for (const [type, elst] of type2elst) {
|
|
615
|
+
listAllEvents(elst, table, j, tk, block, isClickMenu);
|
|
616
|
+
}
|
|
617
|
+
if (type2elst.size == 0 && Object.keys(j.info).length) {
|
|
618
|
+
const [t1, t2] = table.addRow();
|
|
619
|
+
t1.text("Diagram");
|
|
620
|
+
showJunctionDiagram(j, tk, t2);
|
|
621
|
+
}
|
|
622
|
+
}
|
|
623
|
+
function makeJunctionTerm(j) {
|
|
624
|
+
const position = `${j.chr}:${j.start + 1}-${j.stop + 1}`;
|
|
625
|
+
return {
|
|
626
|
+
type: TermTypes.JUNCTION,
|
|
627
|
+
id: `${j.chr}:${j.start}-${j.stop}:${j.strand}`,
|
|
628
|
+
name: j.name || `${position} (${j.strand})`,
|
|
629
|
+
chr: j.chr,
|
|
630
|
+
start: j.start,
|
|
631
|
+
stop: j.stop,
|
|
632
|
+
strand: j.strand,
|
|
633
|
+
info: j.info || {}
|
|
634
|
+
};
|
|
635
|
+
}
|
|
636
|
+
function showJunctionDiagram(j, tk, holder) {
|
|
637
|
+
if (typeof j.info != "object" || Object.keys(j.info).length == 0) {
|
|
638
|
+
return;
|
|
639
|
+
}
|
|
640
|
+
const leftgenes = /* @__PURE__ */ new Map();
|
|
641
|
+
if (j.info.exonleft) j.info.exonleft.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
642
|
+
if (j.info.exonleftin) j.info.exonleftin.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
643
|
+
if (j.info.intronleft) j.info.intronleft.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
644
|
+
const rightgenes = /* @__PURE__ */ new Map();
|
|
645
|
+
if (j.info.exonright) j.info.exonright.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
646
|
+
if (j.info.exonrightin) j.info.exonrightin.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
647
|
+
if (j.info.intronright) j.info.intronright.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
|
|
648
|
+
let isoform;
|
|
649
|
+
let strand;
|
|
650
|
+
if (leftgenes.size) {
|
|
651
|
+
if (rightgenes.size) {
|
|
652
|
+
for (const [n, a] of leftgenes) {
|
|
653
|
+
if (rightgenes.has(n)) {
|
|
654
|
+
isoform = n;
|
|
655
|
+
strand = a.strand;
|
|
656
|
+
break;
|
|
657
|
+
}
|
|
658
|
+
}
|
|
659
|
+
} else {
|
|
660
|
+
const a = [...leftgenes][0];
|
|
661
|
+
isoform = a[0];
|
|
662
|
+
strand = a[1].strand;
|
|
663
|
+
}
|
|
664
|
+
} else if (rightgenes.size) {
|
|
665
|
+
const a = [...rightgenes][0];
|
|
666
|
+
isoform = a[0];
|
|
667
|
+
strand = a[1].strand;
|
|
668
|
+
}
|
|
669
|
+
if (isoform) {
|
|
670
|
+
if (strand != "+" && strand != "-") {
|
|
671
|
+
holder.text("unknown strand for " + isoform);
|
|
672
|
+
return;
|
|
673
|
+
}
|
|
674
|
+
import("./spliceevent.noeventdiagram-SUBU5BLZ.js").then((p) => {
|
|
675
|
+
p.samegene({
|
|
676
|
+
isoform,
|
|
677
|
+
reverse: strand == "-",
|
|
678
|
+
ongene: j.info,
|
|
679
|
+
holder
|
|
680
|
+
});
|
|
681
|
+
});
|
|
682
|
+
return;
|
|
683
|
+
}
|
|
684
|
+
import("./spliceevent.noeventdiagram-SUBU5BLZ.js").then((p) => {
|
|
685
|
+
p.differentgenes({
|
|
686
|
+
ongene: j.info,
|
|
687
|
+
holder
|
|
688
|
+
});
|
|
689
|
+
});
|
|
690
|
+
}
|
|
691
|
+
function showEventdiagram_a53ss(j, e, tk, holder, block, isClickMenu) {
|
|
692
|
+
const e2 = {
|
|
693
|
+
junctionB: {
|
|
694
|
+
start: j.start,
|
|
695
|
+
stop: j.stop,
|
|
696
|
+
strand: j.strand,
|
|
697
|
+
v: j.medianReadCount
|
|
698
|
+
},
|
|
699
|
+
a5ss: e.type == JT_a5ss,
|
|
700
|
+
a3ss: e.type == JT_a3ss,
|
|
701
|
+
altinintron: e.altinintron,
|
|
702
|
+
altinexon: e.altinexon,
|
|
703
|
+
frame: e.frame,
|
|
704
|
+
exon5idx: e.exon5idx,
|
|
705
|
+
strand: e.strand,
|
|
706
|
+
sitedist: e.sitedist
|
|
707
|
+
};
|
|
708
|
+
const otherJs = [];
|
|
709
|
+
if (e.junctionA) {
|
|
710
|
+
e2.junctionA = { start: e.junctionA.start, stop: e.junctionA.stop, strand: e.junctionA.strand, v: "..." };
|
|
711
|
+
const aj = structuredClone(e.junctionA);
|
|
712
|
+
aj.name = `E${e.exon5idx + 1}-E${e.exon5idx + 1 + 1}`;
|
|
713
|
+
otherJs.push(aj);
|
|
714
|
+
}
|
|
715
|
+
if (isClickMenu) {
|
|
716
|
+
mayGroupSelect(tk, block, j, otherJs, `${e.gene} ${e.isoform} E${e.exon5idx + 1} ${e.type}`, holder);
|
|
717
|
+
}
|
|
718
|
+
import("./spliceevent.a53ss.diagram-WUHKYRWG.js").then((p) => {
|
|
719
|
+
const text = p.default({
|
|
720
|
+
event: e2,
|
|
721
|
+
holder
|
|
722
|
+
});
|
|
723
|
+
if (!text) return;
|
|
724
|
+
setTimeout(() => {
|
|
725
|
+
if (text.node().getBoundingClientRect().top == 0) return;
|
|
726
|
+
const strandA = e.junctionA.strand;
|
|
727
|
+
fetchReadcount4junctionAbyjunctionBsamples(
|
|
728
|
+
tk,
|
|
729
|
+
block,
|
|
730
|
+
j,
|
|
731
|
+
/* @__PURE__ */ new Map([[e.junctionA.start + "." + e.junctionA.stop + "." + strandA, text]]),
|
|
732
|
+
[[e.junctionA.start, e.junctionA.stop, strandA]]
|
|
733
|
+
);
|
|
734
|
+
}, 1e3);
|
|
735
|
+
});
|
|
736
|
+
}
|
|
737
|
+
function showEventdiagram_skipalt_fetchreadcount(j, e, tk, holder, block, isClickMenu) {
|
|
738
|
+
const e2 = {
|
|
739
|
+
gm: {
|
|
740
|
+
// confirm if can delete
|
|
741
|
+
name: e.gene,
|
|
742
|
+
isoform: e.isoform
|
|
743
|
+
},
|
|
744
|
+
junctionB: {
|
|
745
|
+
data: [{ v: j.medianReadCount }]
|
|
746
|
+
},
|
|
747
|
+
skippedexon: e.skippedexon,
|
|
748
|
+
isskipexon: e.type == JT_exonskip,
|
|
749
|
+
isaltexon: e.type == JT_exonaltuse,
|
|
750
|
+
frame: e.frame,
|
|
751
|
+
junctionAlst: [],
|
|
752
|
+
color: "#99004d"
|
|
753
|
+
};
|
|
754
|
+
const otherJs = [];
|
|
755
|
+
const firstSkipped = Math.min(...e.skippedexon) + 1;
|
|
756
|
+
const lastSkipped = Math.max(...e.skippedexon) + 1;
|
|
757
|
+
if (e.junctionAlst) {
|
|
758
|
+
for (const [i, jA] of e.junctionAlst.entries()) {
|
|
759
|
+
if (jA) {
|
|
760
|
+
const aj = structuredClone(jA);
|
|
761
|
+
aj.name = `E${firstSkipped - 1 + i}-E${firstSkipped + i}`;
|
|
762
|
+
otherJs.push(aj);
|
|
763
|
+
jA.data = [{ v: "..." }];
|
|
764
|
+
e2.junctionAlst.push(jA);
|
|
765
|
+
continue;
|
|
766
|
+
}
|
|
767
|
+
e2.junctionAlst.push(null);
|
|
768
|
+
}
|
|
769
|
+
}
|
|
770
|
+
if (e.up1junction) {
|
|
771
|
+
const uj = structuredClone(e.up1junction);
|
|
772
|
+
uj.name = `E${firstSkipped - 2}-E${firstSkipped - 1}`;
|
|
773
|
+
otherJs.push(uj);
|
|
774
|
+
e.up1junction.data = [{ v: "..." }];
|
|
775
|
+
e2.up1junction = e.up1junction;
|
|
776
|
+
}
|
|
777
|
+
if (e.down1junction) {
|
|
778
|
+
const dj = structuredClone(e.down1junction);
|
|
779
|
+
dj.name = `E${lastSkipped + 1}-E${lastSkipped + 2}`;
|
|
780
|
+
otherJs.push(dj);
|
|
781
|
+
e.down1junction.data = [{ v: "..." }];
|
|
782
|
+
e2.down1junction = e.down1junction;
|
|
783
|
+
}
|
|
784
|
+
if (isClickMenu) {
|
|
785
|
+
const jc = structuredClone({
|
|
786
|
+
// duplicate j.info{} just in case
|
|
787
|
+
chr: j.chr,
|
|
788
|
+
start: j.start,
|
|
789
|
+
stop: j.stop,
|
|
790
|
+
strand: j.strand,
|
|
791
|
+
info: j.info
|
|
792
|
+
});
|
|
793
|
+
jc.name = `E${firstSkipped - 1}-E${lastSkipped + 1}`;
|
|
794
|
+
mayGroupSelect(
|
|
795
|
+
tk,
|
|
796
|
+
block,
|
|
797
|
+
jc,
|
|
798
|
+
otherJs,
|
|
799
|
+
`${e.gene} ${e.isoform} ${e.skippedexon.map((i) => "E" + (i + 1)).join(",")} ${e.type}`,
|
|
800
|
+
holder
|
|
801
|
+
);
|
|
802
|
+
}
|
|
803
|
+
import("./spliceevent.exonskip.diagram-KAFGBL2I.js").then((p) => {
|
|
804
|
+
const [junction2readcounttext, junctionlst] = p.default({
|
|
805
|
+
event: e2,
|
|
806
|
+
holder,
|
|
807
|
+
nophrase: true
|
|
808
|
+
});
|
|
809
|
+
setTimeout(() => {
|
|
810
|
+
for (const [k, text] of junction2readcounttext) {
|
|
811
|
+
if (text.node().getBoundingClientRect().top == 0) {
|
|
812
|
+
return;
|
|
813
|
+
}
|
|
814
|
+
}
|
|
815
|
+
fetchReadcount4junctionAbyjunctionBsamples(tk, block, j, junction2readcounttext, junctionlst);
|
|
816
|
+
}, 1e3);
|
|
817
|
+
});
|
|
818
|
+
}
|
|
819
|
+
function mayGroupSelect(tk, block, mainJ, otherJs, eventlabel, holder) {
|
|
820
|
+
if (!tk.massApp) return;
|
|
821
|
+
for (const j of otherJs) {
|
|
822
|
+
j.chr = mainJ.chr;
|
|
823
|
+
j.info = {
|
|
824
|
+
type: JT_canonical
|
|
825
|
+
};
|
|
826
|
+
}
|
|
827
|
+
holder.append("button").attr("data-testid", "sjpp-junction-select").text(`Select ${otherJs.length + 1} junctions`).on("click", async (event) => {
|
|
828
|
+
await addJunctionCustomTerm(
|
|
829
|
+
tk,
|
|
830
|
+
[makeJunctionTerm(mainJ), ...otherJs.map(makeJunctionTerm)],
|
|
831
|
+
event.currentTarget,
|
|
832
|
+
msgDiv,
|
|
833
|
+
eventlabel
|
|
834
|
+
);
|
|
835
|
+
});
|
|
836
|
+
const msgDiv = holder.append("div").style("font-size", ".7em");
|
|
837
|
+
}
|
|
838
|
+
async function addJunctionCustomTerm(tk, junctions, button, msgDiv, eventlabel) {
|
|
839
|
+
await tk.massApp.dispatch({
|
|
840
|
+
type: "add_customTerm",
|
|
841
|
+
obj: makeJunctionCustomTerm(junctions, eventlabel)
|
|
842
|
+
});
|
|
843
|
+
button.remove();
|
|
844
|
+
msgDiv.text(
|
|
845
|
+
eventlabel ? `${junctions.length} junctions can now be found through variable selection under ${eventlabel}.` : "This junction can now be found through variable selection."
|
|
846
|
+
);
|
|
847
|
+
}
|
|
848
|
+
function listAllEvents(lst, table, j, tk, block, isClickMenu) {
|
|
849
|
+
if (lst.length == 1) {
|
|
850
|
+
const [t1, t2] = table.addRow();
|
|
851
|
+
const e = lst[0];
|
|
852
|
+
t1.append("div").text(e.gene);
|
|
853
|
+
t1.append("div").text(e.isoform).style("font-size", ".8em");
|
|
854
|
+
if (e.type == JT_exonskip || e.type == JT_exonaltuse) {
|
|
855
|
+
showEventdiagram_skipalt_fetchreadcount(j, e, tk, t2, block, isClickMenu);
|
|
856
|
+
} else if (e.type == JT_a5ss || e.type == JT_a3ss) {
|
|
857
|
+
showEventdiagram_a53ss(j, e, tk, t2, block, isClickMenu);
|
|
858
|
+
}
|
|
859
|
+
return;
|
|
860
|
+
}
|
|
861
|
+
const map = /* @__PURE__ */ new Map();
|
|
862
|
+
for (const e of lst) {
|
|
863
|
+
const f = structuredClone(e);
|
|
864
|
+
const v = e.isoform;
|
|
865
|
+
delete f.isoform;
|
|
866
|
+
const key = JSON.stringify(f);
|
|
867
|
+
if (map.has(key)) map.get(key).push(e.isoform);
|
|
868
|
+
else map.set(key, [e.isoform]);
|
|
869
|
+
}
|
|
870
|
+
for (const [key, isolst] of map) {
|
|
871
|
+
const eo = JSON.parse(key);
|
|
872
|
+
eo.isoform = isolst[0];
|
|
873
|
+
const [t1, t2] = table.addRow();
|
|
874
|
+
t1.append("div").text(eo.gene);
|
|
875
|
+
{
|
|
876
|
+
const s = isolst.length >= 5 ? 0.7 : 0.8;
|
|
877
|
+
for (const i of isolst)
|
|
878
|
+
t1.append("div").text(i).style("font-size", s + "em");
|
|
879
|
+
}
|
|
880
|
+
if (eo.type == JT_exonskip || eo.type == JT_exonaltuse) {
|
|
881
|
+
showEventdiagram_skipalt_fetchreadcount(j, eo, tk, t2, block, isClickMenu);
|
|
882
|
+
} else if (eo.type == JT_a5ss || eo.type == JT_a3ss) {
|
|
883
|
+
showEventdiagram_a53ss(j, eo, tk, t2, block, isClickMenu);
|
|
884
|
+
}
|
|
885
|
+
}
|
|
886
|
+
}
|
|
887
|
+
async function fetchReadcount4junctionAbyjunctionBsamples(tk, block, jB, junction2readcounttext, jAlst) {
|
|
888
|
+
const [body, headers] = getParameter(tk, block);
|
|
889
|
+
delete body.rglst;
|
|
890
|
+
delete body.hiddenTypes;
|
|
891
|
+
body.junctionB = { chr: jB.chr, start: jB.start, stop: jB.stop, strand: jB.strand };
|
|
892
|
+
body.junctionAposlst = jAlst;
|
|
893
|
+
try {
|
|
894
|
+
const data = await dofetch3("termdb/junctions/AbyB", { body, headers });
|
|
895
|
+
if (data.error) throw new Error(data.error);
|
|
896
|
+
if (!Array.isArray(data.lst)) throw new Error(".lst[] missing");
|
|
897
|
+
for (const j of data.lst) {
|
|
898
|
+
const key = j.start + "." + j.stop + "." + j.strand;
|
|
899
|
+
if (junction2readcounttext.has(key)) {
|
|
900
|
+
junction2readcounttext.get(key).text(j.v);
|
|
901
|
+
}
|
|
902
|
+
}
|
|
903
|
+
} catch (e) {
|
|
904
|
+
console.error(e.message || e);
|
|
905
|
+
}
|
|
906
|
+
}
|
|
907
|
+
|
|
908
|
+
// j2/makeTk.js
|
|
909
|
+
async function makeTk(tk, block) {
|
|
910
|
+
if ("yscaleUseLog" in tk) {
|
|
911
|
+
if (typeof tk.yscaleUseLog != "boolean") throw new Error("tk.yscaleUseLog not boolean");
|
|
912
|
+
} else {
|
|
913
|
+
tk.yscaleUseLog = true;
|
|
914
|
+
}
|
|
915
|
+
if (tk.hiddentypes) {
|
|
916
|
+
if (typeof tk.hiddentypes != "string") throw new Error("tk.hiddentypes not string");
|
|
917
|
+
}
|
|
918
|
+
if (tk.readcountCutoff) {
|
|
919
|
+
if (!Number.isInteger(tk.readcountCutoff) || tk.readcountCutoff < 0)
|
|
920
|
+
throw new Error("tk.readcountCutoff is not positive integer");
|
|
921
|
+
} else {
|
|
922
|
+
tk.readcountCutoff = 0;
|
|
923
|
+
}
|
|
924
|
+
{
|
|
925
|
+
const pale = "#FFFEAB";
|
|
926
|
+
const dark = "#F7F69E";
|
|
927
|
+
const id1 = Math.random().toString();
|
|
928
|
+
const id2 = Math.random().toString();
|
|
929
|
+
const id3 = Math.random().toString();
|
|
930
|
+
const defs = tk.gleft.append("defs");
|
|
931
|
+
const left = defs.append("linearGradient").attr("id", id1);
|
|
932
|
+
left.append("stop").attr("offset", 0).attr("stop-color", dark);
|
|
933
|
+
left.append("stop").attr("offset", 1).attr("stop-color", "white");
|
|
934
|
+
const mid = defs.append("linearGradient").attr("id", id2);
|
|
935
|
+
mid.append("stop").attr("offset", 0).attr("stop-color", pale);
|
|
936
|
+
mid.append("stop").attr("offset", 0.5).attr("stop-color", "white");
|
|
937
|
+
mid.append("stop").attr("offset", 1).attr("stop-color", pale);
|
|
938
|
+
const right = defs.append("linearGradient").attr("id", id3);
|
|
939
|
+
right.append("stop").attr("offset", 0).attr("stop-color", "white");
|
|
940
|
+
right.append("stop").attr("offset", 1).attr("stop-color", dark);
|
|
941
|
+
tk.gradient4spanBackground = {
|
|
942
|
+
left: { id: id1, gradient: left },
|
|
943
|
+
mid: { id: id2, gradient: mid },
|
|
944
|
+
right: { id: id3, gradient: right }
|
|
945
|
+
};
|
|
946
|
+
}
|
|
947
|
+
tk.leftlabels = {
|
|
948
|
+
// all labels are rendered here, except track label
|
|
949
|
+
g: tk.gleft.append("g").attr("transform", "translate(0,17)"),
|
|
950
|
+
doms: {},
|
|
951
|
+
// keys: label name, value: label dom
|
|
952
|
+
// to avoid having to delete all labels upon tk rendering
|
|
953
|
+
laby: 0,
|
|
954
|
+
// cumulative height, 0 for no labels
|
|
955
|
+
xoff: 0,
|
|
956
|
+
maxwidth: 0
|
|
957
|
+
// set default 0 in case track runs into err, can still render tk
|
|
958
|
+
};
|
|
959
|
+
tk.leftlabels.doms.jug = makelabel(tk, block, 0);
|
|
960
|
+
{
|
|
961
|
+
const g = tk.glider.append("g");
|
|
962
|
+
tk.sections = {
|
|
963
|
+
// sections from top to bottom.
|
|
964
|
+
jug: {
|
|
965
|
+
height: 0,
|
|
966
|
+
// total height of the jug section
|
|
967
|
+
g: g.append("g"),
|
|
968
|
+
axis: g.append("g"),
|
|
969
|
+
yAxisKey: void 0
|
|
970
|
+
// key of the junction attribute for y axis, set in renderTk()
|
|
971
|
+
}
|
|
972
|
+
};
|
|
973
|
+
}
|
|
974
|
+
setH(tk, "axisheight", 200);
|
|
975
|
+
setH(tk, "legheight", 50);
|
|
976
|
+
setH(tk, "neckheight", 50);
|
|
977
|
+
tk._finish = loadTk_finish_closure(tk, block);
|
|
978
|
+
tk.hovertip = new Menu();
|
|
979
|
+
tk.itemtip = new Menu();
|
|
980
|
+
tk.menutip = new Menu({ padding: "" });
|
|
981
|
+
tk.load = _load(tk, block);
|
|
982
|
+
if (!tk.custom_data) await initTermdb(tk, block);
|
|
983
|
+
if (tk.filter) await Promise.all(rehydrateFilter(tk.filter, tk.vocabApi));
|
|
984
|
+
tk.tklabel.text(tk.dslabel || tk.name);
|
|
985
|
+
tk.clear = () => {
|
|
986
|
+
tk.sections.jug.g.selectAll("*").remove();
|
|
987
|
+
};
|
|
988
|
+
tk.config_handle = block.maketkconfighandle(tk).on("click", () => {
|
|
989
|
+
configPanel(tk, block);
|
|
990
|
+
});
|
|
991
|
+
initLegend(tk, block);
|
|
992
|
+
}
|
|
993
|
+
function setH(tk, prop, v) {
|
|
994
|
+
const customv = tk[prop];
|
|
995
|
+
if (customv != void 0) {
|
|
996
|
+
if (!Number.isFinite(customv) || customv <= 0) throw new Error("invalid tk." + prop);
|
|
997
|
+
tk.sections.jug[prop] = customv;
|
|
998
|
+
delete tk[prop];
|
|
999
|
+
return;
|
|
1000
|
+
}
|
|
1001
|
+
tk.sections.jug[prop] = v;
|
|
1002
|
+
}
|
|
1003
|
+
function loadTk_finish_closure(tk, block) {
|
|
1004
|
+
return (data) => {
|
|
1005
|
+
tk.legend?.headTd.text(tk.custom_data ? tk.name : tk.dslabel + (tk.filter ? " - " + getFilterName(tk.filter) : ""));
|
|
1006
|
+
if (data) {
|
|
1007
|
+
if (data.error) {
|
|
1008
|
+
tk.sections.jug.height = 40;
|
|
1009
|
+
} else {
|
|
1010
|
+
if (data.junctions?.length == 0) {
|
|
1011
|
+
tk.sections.jug.g.selectAll("*").remove();
|
|
1012
|
+
tk.sections.jug.axis.selectAll("*").remove();
|
|
1013
|
+
tk.sections.jug.g.transition().attr("transform", "translate(0,0)");
|
|
1014
|
+
tk.sections.jug.g.append("text").text("No splice junctions").attr("y", 25).attr("x", block.width / 2).attr("text-anchor", "middle").attr("dominant-baseline", "center");
|
|
1015
|
+
tk.sections.jug.height = 40;
|
|
1016
|
+
}
|
|
1017
|
+
if (data.alert) {
|
|
1018
|
+
console.log("TODO print this alert in tk", data.alert);
|
|
1019
|
+
}
|
|
1020
|
+
}
|
|
1021
|
+
}
|
|
1022
|
+
tk.height_main = tk.sections.jug.height + tk.toppad + tk.bottompad;
|
|
1023
|
+
if (data) {
|
|
1024
|
+
updateLegend(data, tk, block);
|
|
1025
|
+
}
|
|
1026
|
+
setLeftlabelsMaxWidth(tk);
|
|
1027
|
+
tk.leftLabelMaxwidth = tk.leftlabels.maxwidth + tk.leftlabels.xoff, block.tkcloakoff(tk, { error: data ? data.error : null });
|
|
1028
|
+
block.block_setheight();
|
|
1029
|
+
block.setllabel();
|
|
1030
|
+
tk.callbackOnRender?.(tk, block);
|
|
1031
|
+
};
|
|
1032
|
+
}
|
|
1033
|
+
async function initTermdb(tk, block) {
|
|
1034
|
+
if (!tk.dslabel) {
|
|
1035
|
+
throw new Error("tk.dslabel missing");
|
|
1036
|
+
}
|
|
1037
|
+
if (!tk.vocabApi) {
|
|
1038
|
+
const arg = {
|
|
1039
|
+
vocab: {
|
|
1040
|
+
genome: block.genome.name,
|
|
1041
|
+
dslabel: tk.dslabel
|
|
1042
|
+
}
|
|
1043
|
+
};
|
|
1044
|
+
const _ = await import("./vocabulary-6XMG22NZ.js");
|
|
1045
|
+
tk.vocabApi = _.vocabInit(arg);
|
|
1046
|
+
if (!tk.vocabApi.app) {
|
|
1047
|
+
tk.vocabApi.app = { opts: { genome: block.genome } };
|
|
1048
|
+
}
|
|
1049
|
+
}
|
|
1050
|
+
if (!tk.termdbConfig) {
|
|
1051
|
+
tk.termdbConfig = await tk.vocabApi.getTermdbConfig();
|
|
1052
|
+
}
|
|
1053
|
+
if (!tk.termdbConfig.queries?.junction) throw new Error("queries.junction missing");
|
|
1054
|
+
}
|
|
1055
|
+
function _load(tk, block) {
|
|
1056
|
+
return async () => {
|
|
1057
|
+
return await loadTk(tk, block);
|
|
1058
|
+
};
|
|
1059
|
+
}
|
|
1060
|
+
function configPanel(tk, block) {
|
|
1061
|
+
tk.tkconfigtip.clear().showunder(tk.config_handle.node());
|
|
1062
|
+
const holder = tk.tkconfigtip.d;
|
|
1063
|
+
if (!tk.custom_data) {
|
|
1064
|
+
const row = holder.append("div").style("margin-bottom", "15px");
|
|
1065
|
+
row.append("span").html("Read count cutoff ");
|
|
1066
|
+
row.append("input").property("value", tk.readcountCutoff || 0).attr("type", "number").style("width", "50px").on("keyup", (event) => {
|
|
1067
|
+
if (event.code != "Enter" && event.code != "NumpadEnter") return;
|
|
1068
|
+
let v = Number(event.target.value);
|
|
1069
|
+
if (!v || v < 0) {
|
|
1070
|
+
v = 0;
|
|
1071
|
+
}
|
|
1072
|
+
if (v == 0) {
|
|
1073
|
+
if (tk.readcountCutoff) {
|
|
1074
|
+
tk.readcountCutoff = 0;
|
|
1075
|
+
loadTk(tk, block, true);
|
|
1076
|
+
} else {
|
|
1077
|
+
}
|
|
1078
|
+
return;
|
|
1079
|
+
}
|
|
1080
|
+
if (tk.readcountCutoff) {
|
|
1081
|
+
if (tk.readcountCutoff == v) {
|
|
1082
|
+
} else {
|
|
1083
|
+
tk.readcountCutoff = v;
|
|
1084
|
+
loadTk(tk, block, true);
|
|
1085
|
+
}
|
|
1086
|
+
} else {
|
|
1087
|
+
tk.readcountCutoff = v;
|
|
1088
|
+
loadTk(tk, block, true);
|
|
1089
|
+
}
|
|
1090
|
+
});
|
|
1091
|
+
row.append("div").style("font-size", ".7em").style("color", "#858585").text("For a junction, samples with read count lower than cutoff will not be shown.");
|
|
1092
|
+
}
|
|
1093
|
+
{
|
|
1094
|
+
const k = tk.sections.jug;
|
|
1095
|
+
const row = holder.append("div").style("margin-bottom", "15px");
|
|
1096
|
+
row.append("span").text("Track height");
|
|
1097
|
+
row.append("button").html(" + ").style("margin-left", "10px").on("click", () => {
|
|
1098
|
+
k.axisheight += 30;
|
|
1099
|
+
k.legheight = k.axisheight / 4;
|
|
1100
|
+
renderTk(null, tk, block);
|
|
1101
|
+
block.block_setheight();
|
|
1102
|
+
});
|
|
1103
|
+
row.append("button").html(" - ").style("margin-left", "5px").on("click", () => {
|
|
1104
|
+
if (k.axisheight <= 90) return;
|
|
1105
|
+
k.axisheight -= 30;
|
|
1106
|
+
k.legheight = k.axisheight / 4;
|
|
1107
|
+
renderTk(null, tk, block);
|
|
1108
|
+
block.block_setheight();
|
|
1109
|
+
});
|
|
1110
|
+
}
|
|
1111
|
+
if (tk.sections.jug.yAxisKey == "medianReadCount") {
|
|
1112
|
+
const row = holder.append("div").style("margin-bottom", "1px");
|
|
1113
|
+
const id = Math.random();
|
|
1114
|
+
const input = row.append("input").attr("type", "checkbox").style("margin-right", "10px").attr("id", id).on("change", () => {
|
|
1115
|
+
tk.yscaleUseLog = !tk.yscaleUseLog;
|
|
1116
|
+
renderTk(null, tk, block);
|
|
1117
|
+
});
|
|
1118
|
+
if (tk.yscaleUseLog) {
|
|
1119
|
+
input.property("checked", 1);
|
|
1120
|
+
}
|
|
1121
|
+
row.append("label").text("Use log10 for Y scale read count").attr("for", id);
|
|
1122
|
+
}
|
|
1123
|
+
}
|
|
1124
|
+
|
|
1125
|
+
// j2/tk.js
|
|
1126
|
+
async function loadTk(tk, block) {
|
|
1127
|
+
block.tkcloakon(tk);
|
|
1128
|
+
block.block_setheight();
|
|
1129
|
+
try {
|
|
1130
|
+
if (tk.uninitialized) {
|
|
1131
|
+
await makeTk(tk, block);
|
|
1132
|
+
delete tk.uninitialized;
|
|
1133
|
+
}
|
|
1134
|
+
const data = await getTkData(tk, block);
|
|
1135
|
+
renderTk(data, tk, block);
|
|
1136
|
+
tk._finish(data);
|
|
1137
|
+
} catch (e) {
|
|
1138
|
+
if (tk.clear) tk.clear();
|
|
1139
|
+
if (tk._finish) tk._finish({ error: e.message || e });
|
|
1140
|
+
if (e.stack) console.log(e.stack);
|
|
1141
|
+
}
|
|
1142
|
+
}
|
|
1143
|
+
function getParameter(tk, block) {
|
|
1144
|
+
const par = {
|
|
1145
|
+
genome: block.genome.name,
|
|
1146
|
+
dslabel: tk.dslabel,
|
|
1147
|
+
filter0: tk.filter0,
|
|
1148
|
+
filter: tk.filter,
|
|
1149
|
+
readcountCutoff: tk.readcountCutoff
|
|
1150
|
+
};
|
|
1151
|
+
const headers = { "Content-Type": "application/json", Accept: "application/json" };
|
|
1152
|
+
rangequery_rglst(tk, block, par);
|
|
1153
|
+
if (tk.legend?.type?.hiddenvalues?.size) par.hiddenTypes = [...tk.legend.type.hiddenvalues].join(",");
|
|
1154
|
+
return [par, headers];
|
|
1155
|
+
}
|
|
1156
|
+
async function getTkData(tk, block) {
|
|
1157
|
+
let data;
|
|
1158
|
+
if (tk.custom_data) {
|
|
1159
|
+
data = await dataFromCustomData(tk, block);
|
|
1160
|
+
} else {
|
|
1161
|
+
const [body, headers] = getParameter(tk, block);
|
|
1162
|
+
data = await dofetch3("termdb/junctions", { body, headers });
|
|
1163
|
+
}
|
|
1164
|
+
if (data.error) throw new Error(data.error);
|
|
1165
|
+
return data;
|
|
1166
|
+
}
|
|
1167
|
+
async function dataFromCustomData(tk, block) {
|
|
1168
|
+
const hidden = tk.legend?.type?.hiddenvalues;
|
|
1169
|
+
const junctions = tk.custom_data.flatMap((j) => {
|
|
1170
|
+
if (typeof j.chr != "string" || !Number.isInteger(j.start) || !Number.isInteger(j.stop))
|
|
1171
|
+
throw new Error("custom junction requires chr, start and stop");
|
|
1172
|
+
const types = (j.types || []).filter((t) => !hidden?.has(t));
|
|
1173
|
+
if (j.types?.length && !types.length) return [];
|
|
1174
|
+
const info = { ...j.info };
|
|
1175
|
+
if (info.events) {
|
|
1176
|
+
info.events = info.events.filter((e) => !hidden?.has(e.type));
|
|
1177
|
+
if (!info.events.length) delete info.events;
|
|
1178
|
+
}
|
|
1179
|
+
const j2 = { ...j, types, info };
|
|
1180
|
+
if (j.sv) j2.sv = { ...j.sv, mate: { ...j.sv.mate } };
|
|
1181
|
+
if (Number.isFinite(j.p)) j2.negLog10p = -Math.log10(Math.max(j.p, Number.MIN_VALUE));
|
|
1182
|
+
return [j2];
|
|
1183
|
+
});
|
|
1184
|
+
const data = { junctions };
|
|
1185
|
+
if (junctions.every((j) => Number.isFinite(j.medianReadCount)))
|
|
1186
|
+
data.maxReadCount = Math.max(...junctions.map((j) => j.medianReadCount));
|
|
1187
|
+
return data;
|
|
1188
|
+
}
|
|
1189
|
+
export {
|
|
1190
|
+
getParameter,
|
|
1191
|
+
loadTk
|
|
1192
|
+
};
|
|
1193
|
+
//# sourceMappingURL=tk-7OE7QMYG.js.map
|