@sjcrh/proteinpaint-client 2.210.0 → 2.210.1

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (915) hide show
  1. package/dist/2dmaf-7VZ536T5.js +1367 -0
  2. package/dist/AggMatrixInput-UTUOXTGA.js +406 -0
  3. package/dist/AggregateMatrix-X75HUZYO.js +41 -0
  4. package/dist/AppHeader-X2DR6VSM.js +830 -0
  5. package/dist/BoxPlot-NQMPJICU.js +1211 -0
  6. package/dist/CorrelationVolcano-IDBUJH2E.js +617 -0
  7. package/dist/Cuminc-BYFIMOLO.js +1219 -0
  8. package/dist/DE-BI7DHHW4.js +89 -0
  9. package/dist/DEinput-W66CT4U2.js +501 -0
  10. package/dist/DM-62TEJA3C.js +90 -0
  11. package/dist/DifferentialAnalysis-PRTA6CYW.js +239 -0
  12. package/dist/Disco-4JQP3FRW.js +3389 -0
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  14. package/dist/DmrPlot-VYQYMTQ7.js +362 -0
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  17. package/dist/GSEA-DT3SYXOZ.js +875 -0
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  161. package/dist/databrowser.ui-L2K7VVDW.js +425 -0
  162. package/dist/dictionary-MS6R3VNY.js +113 -0
  163. package/dist/dnaMethylation-2KYSQWNE.js +33 -0
  164. package/dist/dnaMethylation.integration.spec-2BHNKOGN.js +198 -0
  165. package/dist/dofetch-BETN7HEX.js +48 -0
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  167. package/dist/ep-BTRMR4OT.js +1249 -0
  168. package/dist/expclust.gdc.spec-C5ZMBCGO.js +302 -0
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  171. package/dist/geneExpClustering-OXZJHEPD.js +244 -0
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  177. package/dist/geneVariant-NJYUEY4C.js +36 -0
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  180. package/dist/genefusion.ui-B6J7I3RA.js +303 -0
  181. package/dist/geneset-VG4SFYML.js +203 -0
  182. package/dist/genomeBrowser.spec-5IS5Y2NG.js +276 -0
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  823. /package/dist/{matrix.sort.unit.spec-BCWE4AFX.js.map → matrix.sort.unit.spec-EQEHQXTO.js.map} +0 -0
  824. /package/dist/{matrix.sorterUi-WL5I6S3K.js.map → matrix.sorterUi-GFQG4HFV.js.map} +0 -0
  825. /package/dist/{matrix.sorterUi.unit.spec-XJR5KXRL.js.map → matrix.sorterUi.unit.spec-XQHFOEYE.js.map} +0 -0
  826. /package/dist/{matrix.unit.spec-TUCKPE26.js.map → matrix.unit.spec-4ZWUGZUC.js.map} +0 -0
  827. /package/dist/{mavb-GWSNRBLM.js.map → mavb-3CL5OHWB.js.map} +0 -0
  828. /package/dist/{mds.fimo-OMAQRSMW.js.map → mds.fimo-2RFJQKJM.js.map} +0 -0
  829. /package/dist/{mds.samplescatterplot-4UW3CC45.js.map → mds.samplescatterplot-X6CXMY4C.js.map} +0 -0
  830. /package/dist/{mds.survivalplot-2CJYJBD2.js.map → mds.survivalplot-57NIKSSH.js.map} +0 -0
  831. /package/dist/{multivalue-G44MHEYI.js.map → multivalue-3TUGYL4J.js.map} +0 -0
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  833. /package/dist/{oncomatrix-ZTVO23ZH.js.map → oncomatrix-COK76MJN.js.map} +0 -0
  834. /package/dist/{oncomatrix.spec-2QVK2A3Q.js.map → oncomatrix.spec-SO3ZN5BF.js.map} +0 -0
  835. /package/dist/{plot.2dvaf-CL5YUXKH.js.map → plot.2dvaf-TETCE4VG.js.map} +0 -0
  836. /package/dist/{plot.app-4ANKPSNP.js.map → plot.app-5YUAVZA4.js.map} +0 -0
  837. /package/dist/{plot.barplot-BMGDNZRA.js.map → plot.barplot-JUGY5Z7A.js.map} +0 -0
  838. /package/dist/{plot.boxplot-GMLQCDP6.js.map → plot.boxplot-QZXICT7J.js.map} +0 -0
  839. /package/dist/{plot.brainImaging-RZXX3NUZ.js.map → plot.brainImaging-2F6E6QS4.js.map} +0 -0
  840. /package/dist/{plot.disco-3MD4J4C7.js.map → plot.disco-H4P4B6QS.js.map} +0 -0
  841. /package/dist/{plot.ssgq-ZC4UYKOT.js.map → plot.ssgq-LEQF3STZ.js.map} +0 -0
  842. /package/dist/{plot.vaf2cov-4DHFMYQV.js.map → plot.vaf2cov-UBMD2CN7.js.map} +0 -0
  843. /package/dist/{polar2-TMB5EITR.js.map → polar2-AVEZM2T5.js.map} +0 -0
  844. /package/dist/{profileForms-GD7BIOOD.js.map → profileForms-CUSUGTPC.js.map} +0 -0
  845. /package/dist/{profilePlot-CZLK5E74.js.map → profilePlot-67Z7AXQ4.js.map} +0 -0
  846. /package/dist/{proteinView-FEEEXLKT.js.map → proteinView-7K7VHGX3.js.map} +0 -0
  847. /package/dist/{proteomeCohortCompare-NVLJ2FXX.js.map → proteomeCohortCompare-MRGH6HHI.js.map} +0 -0
  848. /package/dist/{pseudbulk.unit.spec-GHQZPNAH.js.map → pseudbulk.unit.spec-ZHDL6GIM.js.map} +0 -0
  849. /package/dist/{pseudobulk-G5UQIRKL.js.map → pseudobulk-ZNXPF7QB.js.map} +0 -0
  850. /package/dist/{qualitative-EAUUCKU5.js.map → qualitative-QXMZHDWU.js.map} +0 -0
  851. /package/dist/{radar2-CJQ2L6KE.js.map → radar2-QJDGNLED.js.map} +0 -0
  852. /package/dist/{radarFacility2-BLVRZE4V.js.map → radarFacility2-LGGOOWX4.js.map} +0 -0
  853. /package/dist/{rememberedGvQ.unit.spec-DYRO2LO5.js.map → rememberedGvQ.unit.spec-YKUMMYFT.js.map} +0 -0
  854. /package/dist/{render-KKAQPH6Y.js.map → render-LSSRZJY3.js.map} +0 -0
  855. /package/dist/{report-OSOJHTSD.js.map → report-TTECPO44.js.map} +0 -0
  856. /package/dist/{sampleView-WB74RLD7.js.map → sampleView-EFS2UBRS.js.map} +0 -0
  857. /package/dist/{samplelst-ZKXV5WOD.js.map → samplelst-FXULLJBO.js.map} +0 -0
  858. /package/dist/{samplematrix-WJFYMWLT.js.map → samplematrix-MNFCXOWO.js.map} +0 -0
  859. /package/dist/{sc-RBRBUCLR.js.map → sc-2BUOXML2.js.map} +0 -0
  860. /package/dist/{scatter-SM7GQENM.js.map → scatter-AVRTALYY.js.map} +0 -0
  861. /package/dist/{scatter-5K3QTIDK.js.map → scatter-CPEIVL3K.js.map} +0 -0
  862. /package/dist/{selectGenomeWithTklst-ZZUJ7AQ7.js.map → selectGenomeWithTklst-3BG2ZPPN.js.map} +0 -0
  863. /package/dist/{singleCellCellType-LCF2JNZ2.js.map → singleCellCellType-QLAEBVN2.js.map} +0 -0
  864. /package/dist/{singleCellCellType.unit.spec-T6DYH4BC.js.map → singleCellCellType.unit.spec-P4NAWYKL.js.map} +0 -0
  865. /package/dist/{singleCellGeneExpression-2XUYTH4C.js.map → singleCellGeneExpression-IZ2PMDDL.js.map} +0 -0
  866. /package/dist/{singleCellGeneExpression.unit.spec-SMRCLOF4.js.map → singleCellGeneExpression.unit.spec-DKBZICJM.js.map} +0 -0
  867. /package/dist/{singleCellNumericValue-57I33FZT.js.map → singleCellNumericValue-NB3QFH7H.js.map} +0 -0
  868. /package/dist/{singleCellNumericValue.unit.spec-4YNB4OEV.js.map → singleCellNumericValue.unit.spec-ZKK2KWRQ.js.map} +0 -0
  869. /package/dist/{singleCellPlot-L6TKQHGD.js.map → singleCellPlot-ZU655L4Z.js.map} +0 -0
  870. /package/dist/{singlecell-UKN2VCXQ.js.map → singlecell-NKPTXVHW.js.map} +0 -0
  871. /package/dist/{singlecell-LZKR3UDV.js.map → singlecell-PEIEFXVU.js.map} +0 -0
  872. /package/dist/{snp-3LJITU5B.js.map → snp-G55JGINX.js.map} +0 -0
  873. /package/dist/{snp.unit.spec-ZQNU6XRM.js.map → snp.unit.spec-47CCZKJO.js.map} +0 -0
  874. /package/dist/{snplocus-OME7UQBW.js.map → snplocus-TRVAEAPF.js.map} +0 -0
  875. /package/dist/{spliceevent.a53ss.diagram-C32IEFMU.js.map → spliceevent.a53ss.diagram-FL2R6F22.js.map} +0 -0
  876. /package/dist/{spliceevent.exonskip.diagram-CZ7MVRLK.js.map → spliceevent.exonskip.diagram-XDZWTJXR.js.map} +0 -0
  877. /package/dist/{spliceevent.noeventdiagram-ZO6R3776.js.map → spliceevent.noeventdiagram-L322N534.js.map} +0 -0
  878. /package/dist/{ssGSEA-BGPQ2PFY.js.map → ssGSEA-DZY4LFQY.js.map} +0 -0
  879. /package/dist/{ssGSEA.unit.spec-U7TBUSSK.js.map → ssGSEA.unit.spec-P6C3VTVZ.js.map} +0 -0
  880. /package/dist/{stattable-FISGQCED.js.map → stattable-R7O6OIMB.js.map} +0 -0
  881. /package/dist/{studyCatalog-UHFUT2CJ.js.map → studyCatalog-OMDE4JRD.js.map} +0 -0
  882. /package/dist/{summarizeCnvGeneexp-OVZO6KIB.js.map → summarizeCnvGeneexp-A7HW6FJI.js.map} +0 -0
  883. /package/dist/{summarizeGeneexpSurvival-KVQ4JGWK.js.map → summarizeGeneexpSurvival-ODI4HGFH.js.map} +0 -0
  884. /package/dist/{summarizeMutationCnv-RAKGHNLE.js.map → summarizeMutationCnv-C2YB73OL.js.map} +0 -0
  885. /package/dist/{summarizeMutationDiagnosis-LGCINAGG.js.map → summarizeMutationDiagnosis-4Y322NYU.js.map} +0 -0
  886. /package/dist/{summarizeMutationSurvival-J7H7L4FX.js.map → summarizeMutationSurvival-7IHNURLC.js.map} +0 -0
  887. /package/dist/{summary-2632JZXH.js.map → summary-E4L5MZTF.js.map} +0 -0
  888. /package/dist/{summary.integration.spec-5WBS2ZRP.js.map → summary.integration.spec-SDCGE6BQ.js.map} +0 -0
  889. /package/dist/{summaryInput-BH6C3ATV.js.map → summaryInput-DHIMU5DM.js.map} +0 -0
  890. /package/dist/{sunburst-AMRR2IHM.js.map → sunburst-ULNPFEAM.js.map} +0 -0
  891. /package/dist/{survival-WYCH4QOQ.js.map → survival-CU4N5KZO.js.map} +0 -0
  892. /package/dist/{survival-2RNJQVFS.js.map → survival-KWWH6REE.js.map} +0 -0
  893. /package/dist/{survival.integration.spec-7IFPY4I4.js.map → survival.integration.spec-UW6SYVLP.js.map} +0 -0
  894. /package/dist/{svgraph-YQWS52ZJ.js.map → svgraph-HFI6NNF3.js.map} +0 -0
  895. /package/dist/{svmr-NRN6LGKK.js.map → svmr-VHS7Z4SO.js.map} +0 -0
  896. /package/dist/{table-3QOMV2NN.js.map → table-GJUXHKQI.js.map} +0 -0
  897. /package/dist/{termCollection-2ZJ7TJGO.js.map → termCollection-CCZ4BFIU.js.map} +0 -0
  898. /package/dist/{termCollection-3MCVR7BA.js.map → termCollection-O5CQ472U.js.map} +0 -0
  899. /package/dist/{termCollection.unit.spec-QYOEA3X6.js.map → termCollection.unit.spec-KR5G6JFU.js.map} +0 -0
  900. /package/dist/{termCollectionFractionSelection-5AH6EF4L.js.map → termCollectionFractionSelection-IKU5MFBT.js.map} +0 -0
  901. /package/dist/{termCollectionFractionSelection.unit.spec-WPGW4WJN.js.map → termCollectionFractionSelection.unit.spec-6ZWHNGES.js.map} +0 -0
  902. /package/dist/{tk-DQ7D5UEO.js.map → tk-3DLMAFW7.js.map} +0 -0
  903. /package/dist/{tk-ONKYBG6R.js.map → tk-CAYWF7LX.js.map} +0 -0
  904. /package/dist/{tp.ui-C7BTMHEI.js.map → tp.ui-NF5ZYOHW.js.map} +0 -0
  905. /package/dist/{tvs.dt-PLRMK7OT.js.map → tvs.dt-43A4SSLG.js.map} +0 -0
  906. /package/dist/{tvs.dtcnv.categorical-IZUY2AQO.js.map → tvs.dtcnv.categorical-DYXHUNP2.js.map} +0 -0
  907. /package/dist/{tvs.dtcnv.continuous-ENV3RHHA.js.map → tvs.dtcnv.continuous-NOKNP4UG.js.map} +0 -0
  908. /package/dist/{tvs.dtfusion-2DVCV6AM.js.map → tvs.dtfusion-4NAOCC2X.js.map} +0 -0
  909. /package/dist/{tvs.dtitd-XNDIRQYU.js.map → tvs.dtitd-SZC6EITI.js.map} +0 -0
  910. /package/dist/{tvs.dtsnvindel-4D3G7XSF.js.map → tvs.dtsnvindel-EYSBCNQK.js.map} +0 -0
  911. /package/dist/{tvs.dtsv-QYMIMC4Z.js.map → tvs.dtsv-VSPWIIFO.js.map} +0 -0
  912. /package/dist/{tvs.samplelst-2KEU2ZWB.js.map → tvs.samplelst-3YQ4GKNG.js.map} +0 -0
  913. /package/dist/{tvs.termCollection-FEY746V5.js.map → tvs.termCollection-EVM4ATPW.js.map} +0 -0
  914. /package/dist/{vocabulary-BR4NJDPS.js.map → vocabulary-HCPEIO2P.js.map} +0 -0
  915. /package/dist/{wsi.direct-JWDUNHIO.js.map → wsi.direct-K2J6GGWY.js.map} +0 -0
@@ -1,1121 +0,0 @@
1
- import {
2
- getFilterName,
3
- makelabel,
4
- printCategory,
5
- rangequery_rglst
6
- } from "./chunk-QBNDPW7O.js";
7
- import {
8
- makeJunctionCustomTerm
9
- } from "./chunk-JTANDSTD.js";
10
- import {
11
- rehydrateFilter
12
- } from "./chunk-SKMFMGCD.js";
13
- import "./chunk-F47A4CVK.js";
14
- import {
15
- legend_newrow
16
- } from "./chunk-NQNVLZOA.js";
17
- import "./chunk-V2OJLJSK.js";
18
- import "./chunk-4FTH4L3A.js";
19
- import "./chunk-4XYQG3XU.js";
20
- import {
21
- axisstyle,
22
- table2col
23
- } from "./chunk-55FABQU2.js";
24
- import "./chunk-HJ6L54YS.js";
25
- import "./chunk-KV4W2ACA.js";
26
- import "./chunk-UXD6G6G4.js";
27
- import {
28
- Menu
29
- } from "./chunk-ELJX3QIQ.js";
30
- import "./chunk-3FEP6B5T.js";
31
- import "./chunk-EEB5VE2A.js";
32
- import "./chunk-6RRZRISL.js";
33
- import "./chunk-2KM4PRQM.js";
34
- import {
35
- dofetch3
36
- } from "./chunk-VA57CUC7.js";
37
- import "./chunk-BK6UDL7F.js";
38
- import "./chunk-KIAMLQ7S.js";
39
- import {
40
- JT_a3ss,
41
- JT_a5ss,
42
- JT_canonical,
43
- JT_exonaltuse,
44
- JT_exonskip,
45
- JTypes,
46
- TermTypes,
47
- bplen
48
- } from "./chunk-SB36AUG7.js";
49
- import "./chunk-WINIL2KN.js";
50
- import "./chunk-PF4DSFDR.js";
51
- import "./chunk-7X6NF7NI.js";
52
- import "./chunk-W5J3LTYS.js";
53
- import {
54
- axisRight,
55
- collide_default,
56
- simulation_default,
57
- x_default,
58
- y_default
59
- } from "./chunk-Z2ZITHT4.js";
60
- import {
61
- linear,
62
- log
63
- } from "./chunk-4OLM3KSB.js";
64
- import "./chunk-FXQXCOII.js";
65
- import "./chunk-TLT4YIG3.js";
66
- import "./chunk-5R63Q5KH.js";
67
- import {
68
- select_default
69
- } from "./chunk-I6Y4O3RR.js";
70
- import "./chunk-Q5RDQNIT.js";
71
- import "./chunk-DQC5FFGV.js";
72
- import "./chunk-HS5PO5ZQ.js";
73
-
74
- // j2/legend.js
75
- function initLegend(tk, block) {
76
- if (!block.legend) return;
77
- if (!tk.legend) tk.legend = {};
78
- tk.legend.tip = new Menu({ padding: "0px" });
79
- const [tr, td, td0] = legend_newrow(block, tk.dslabel);
80
- tk.legend.headTd = td0;
81
- tk.tr_legend = tr;
82
- const table = td.append("table").style("border-spacing", "5px").style("border-collapse", "separate");
83
- tk.legend.table = table;
84
- create_type(tk, block);
85
- }
86
- function updateLegend(data, tk, block) {
87
- if (!tk.legend) {
88
- return;
89
- }
90
- update_type(tk);
91
- }
92
- function create_type(tk, block) {
93
- if (!tk.legend.type) tk.legend.type = {};
94
- if (!tk.legend.type.hiddenvalues) tk.legend.type.hiddenvalues = /* @__PURE__ */ new Set();
95
- if (tk.hiddentypes) {
96
- for (const c of tk.hiddentypes.split(",")) tk.legend.type.hiddenvalues.add(c);
97
- delete tk.hiddentypes;
98
- }
99
- tk.legend.type.row = tk.legend.table.append("tr");
100
- tk.legend.type.row.append("td").attr("data-testid", "sjpp-j2-legend-row-type").style("text-align", "right").style("opacity", 0.7).text("Type");
101
- tk.legend.type.holder = tk.legend.type.row.append("td");
102
- }
103
- function update_type(tk) {
104
- if (tk.hardcodeCnvOnly) return;
105
- const type2count = /* @__PURE__ */ new Map();
106
- for (const j of tk.data) {
107
- for (const t of j.types) {
108
- type2count.set(t, 1 + (type2count.get(t) || 0));
109
- }
110
- }
111
- tk.legend.type.holder.selectAll("*").remove();
112
- for (const [t, c] of [...type2count].sort((i, j) => j[1] - i[1])) {
113
- printCategory({
114
- holder: tk.legend.type.holder,
115
- key: t,
116
- label: JTypes[t].name,
117
- color: JTypes[t].color,
118
- count: c,
119
- testid: "sjpp-j2-legend-row-type-item",
120
- click: (event) => {
121
- const opts = [
122
- {
123
- label: "Hide",
124
- callback: () => {
125
- tk.legend.type.hiddenvalues.add(t);
126
- }
127
- },
128
- {
129
- label: "Show only",
130
- callback: () => {
131
- for (const t2 of type2count.keys()) {
132
- tk.legend.type.hiddenvalues.add(t2);
133
- }
134
- tk.legend.type.hiddenvalues.delete(t);
135
- }
136
- },
137
- {
138
- label: "Show all",
139
- isVisible: () => tk.legend.type.hiddenvalues.size,
140
- callback: () => {
141
- tk.legend.type.hiddenvalues.clear();
142
- }
143
- }
144
- ];
145
- tk.legend.tip.clear().showunder(event.target);
146
- for (const o of opts) {
147
- if (o.isVisible && o.isVisible() == false) continue;
148
- tk.legend.tip.d.append("div").attr("class", "sja_menuoption").attr("data-testid", `sjpp-legend-option-${o.label.toLowerCase().replace(/\s/g, "-")}`).style("border-radius", "0px").text(o.label).on("click", () => {
149
- o.callback();
150
- tk.legend.tip.hide();
151
- tk.load();
152
- });
153
- }
154
- }
155
- });
156
- }
157
- for (const c of tk.legend.type.hiddenvalues) {
158
- let loading = false;
159
- tk.legend.type.holder.append("div").style("display", "inline-block").attr("class", "sja_clb").style("text-decoration", "line-through").style("opacity", 0.7).text(JTypes[c].name).on("click", async (event) => {
160
- if (loading) return;
161
- loading = true;
162
- tk.legend.type.hiddenvalues.delete(c);
163
- event.target.innerHTML = "Updating...";
164
- await tk.load();
165
- });
166
- }
167
- }
168
-
169
- // j2/render.js
170
- var minfontsize = 12;
171
- var lineopacity = 0.5;
172
- var discopacity = 0.5;
173
- function renderTk(data, tk, block) {
174
- if (data) {
175
- if (data.junctions?.length == 0) {
176
- tk.data = [];
177
- tk.leftlabels?.doms?.jug?.text("0 junctions");
178
- return;
179
- }
180
- if (!Number.isFinite(data.maxReadCount)) throw new Error("data.maxReadCount is not number");
181
- rawdata2track(data.junctions, tk, block);
182
- } else {
183
- }
184
- tk.leftlabels.doms.jug.text(`${tk.data.length} junction${tk.data.length > 1 ? "s" : ""}`);
185
- const viewpxwidth = block.width + block.subpanels.reduce((i, j) => i + j.leftpad + j.width, 0);
186
- setColor(tk);
187
- tk.sections.jug.g.selectAll("*").remove();
188
- const mg = tk.sections.jug.g;
189
- tk.data.sort((a, b) => {
190
- return a._x - b._x;
191
- });
192
- const maxsamplecount = tk.data.reduce((max, j) => Math.max(max, j.sampleCount), 0);
193
- {
194
- const radius = 5;
195
- let mrd = 0;
196
- const w = Math.pow(radius, 2) * Math.PI;
197
- if (maxsamplecount <= 10) {
198
- mrd = w * maxsamplecount * 0.9;
199
- } else if (maxsamplecount <= 100) {
200
- mrd = w * 10;
201
- } else if (maxsamplecount <= 1e3) {
202
- mrd = w * 14;
203
- } else {
204
- mrd = w * 20;
205
- }
206
- const sf_discradius = linear().domain([
207
- 1,
208
- maxsamplecount * 0.5 + 0.1,
209
- maxsamplecount * 0.6 + 0.1,
210
- maxsamplecount * 0.7 + 0.1,
211
- maxsamplecount * 0.8 + 0.1,
212
- maxsamplecount
213
- ]).range([w, w + (mrd - w) * 0.8, w + (mrd - w) * 0.85, w + (mrd - w) * 0.9, w + (mrd - w) * 0.95, mrd]);
214
- let maxradius = 0;
215
- for (const j of tk.data) {
216
- j.radius = Math.sqrt(sf_discradius(j.sampleCount) / Math.PI);
217
- if (j.sampleCount > 1) {
218
- mg.append("text").attr("font-family", "Arial").attr("font-size", Math.max(minfontsize, j.radius)).text(j.sampleCount).each(function() {
219
- const b = this.getBBox();
220
- const newrad = Math.sqrt(Math.pow(b.width, 2) + Math.pow(b.height, 2)) / 2;
221
- j.radius = Math.max(j.radius, newrad);
222
- }).remove();
223
- }
224
- j.rimwidth = j.rimcount ? Math.max(2, j.radius / 6) : 0;
225
- j.radius2 = j.radius + j.rimwidth + (j.rimwidth > 0 ? 1 : 0);
226
- maxradius = Math.max(maxradius, j.radius2);
227
- }
228
- tk.maxradius = maxradius;
229
- }
230
- const maxmedian = tk.data.reduce((c, j) => Math.max(c, j.medianReadCount), 0);
231
- tk.sections.jug.yscale = (tk.yscaleUseLog ? log() : linear()).domain([tk.readcountCutoff || 1, data.maxReadCount]).range([tk.sections.jug.axisheight, 0]);
232
- for (const j of tk.data) {
233
- if (j.axisy == void 0) {
234
- j.axisy = tk.sections.jug.axisheight - tk.sections.jug.yscale(j.medianReadCount);
235
- }
236
- }
237
- tk.sections.jug.height = tk.sections.jug.axisheight + tk.sections.jug.neckheight + tk.sections.jug.legheight;
238
- mg.attr("transform", `translate(0,${tk.sections.jug.height})`);
239
- {
240
- const topy = -tk.sections.jug.legheight - tk.sections.jug.neckheight - tk.sections.jug.axisheight;
241
- mg.append("line").attr("x1", 0).attr("y1", topy).attr("y2", topy).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("shape-rendering", "crispEdges");
242
- mg.append("line").attr("x1", 0).attr("y1", topy + tk.sections.jug.axisheight).attr("y2", topy + tk.sections.jug.axisheight).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("shape-rendering", "crispEdges");
243
- let v = 10;
244
- while (v <= data.maxReadCount) {
245
- mg.append("line").attr("x1", 0).attr("y1", topy + tk.sections.jug.yscale(v)).attr("y2", topy + tk.sections.jug.yscale(v)).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("stroke-dasharray", "4,4").attr("shape-rendering", "crispEdges");
246
- v *= 10;
247
- }
248
- }
249
- const jug = mg.selectAll().data(tk.data).enter().append("g").attr("class", "sja_jug").attr("transform", (d) => set_jug(d)).each(function(j) {
250
- j.jugg = this;
251
- });
252
- jug.append("line").attr("stroke", (d) => d.color).attr("x1", (d) => set_leg_x1(d)).attr("y2", -tk.sections.jug.legheight).attr("stroke-opacity", lineopacity).attr("class", "sja_jug_leg1").each(function(d) {
253
- d.leg1 = this;
254
- });
255
- jug.append("line").attr("stroke", (d) => d.color).attr("x2", (d) => set_leg_x2(d)).attr("y1", -tk.sections.jug.legheight).attr("stroke-opacity", lineopacity).attr("class", "sja_jug_leg2").each(function(d) {
256
- d.leg2 = this;
257
- });
258
- const jug2 = jug.append("g").attr("class", "sja_jug_jug2").attr("transform", (d) => set_jug2(d, tk));
259
- jug2.append("line").attr("stroke", (d) => d.color).attr("class", "sja_jug_stem").attr("stroke-dasharray", "2,2").attr("shape-rendering", "crispEdges").attr("y1", (d) => d.radius).attr("y2", (d) => {
260
- return tk.sections.jug.neckheight + d.axisy;
261
- }).attr("stroke-opacity", lineopacity).each(function(d) {
262
- d.stem = this;
263
- });
264
- jug2.append("circle").each(function(d) {
265
- d.disc = this;
266
- }).attr("r", (d) => d.radius).attr("fill", (d) => d.color).attr("stroke", "white").attr("fill-opacity", discopacity);
267
- jug2.filter((d) => d.sampleCount > 1).append("text").text((d) => d.sampleCount).attr("font-size", (d) => Math.max(minfontsize, d.radius)).attr("class", "sja_jug_discnum").attr("fill", "white").attr("font-family", "Arial").attr("text-anchor", "middle").attr("dominant-baseline", "central");
268
- jug2.append("circle").attr("r", (d) => d.radius).attr("stroke", (d) => d.color).attr("fill", "white").attr("fill-opacity", 0).attr("stroke-opacity", 0).on("mouseover", (event, d) => {
269
- event.stopPropagation();
270
- select_default(d.disc).attr("fill-opacity", 0.8);
271
- select_default(d.stem).attr("stroke-opacity", 1);
272
- select_default(d.leg1).attr("stroke-opacity", 1);
273
- select_default(d.leg2).attr("stroke-opacity", 1);
274
- mouseoverSpanBackground(d, tk, block, viewpxwidth);
275
- mouseoverBoxplot(d, tk);
276
- const p = event.target.getBoundingClientRect();
277
- tk.hovertip.clear().show(p.left + p.width, p.top - 50);
278
- showOneJunction(d, tk, tk.hovertip.d, block);
279
- }).on("mouseout", (event, d) => {
280
- tk.hovertip.hide();
281
- tk.pica.g.selectAll("*").remove();
282
- block.cursorhlbar.attr("fill", block.cursorhlbarFillColor);
283
- select_default(d.disc).attr("fill-opacity", discopacity);
284
- select_default(d.stem).attr("stroke-opacity", lineopacity);
285
- select_default(d.leg1).attr("stroke-opacity", lineopacity);
286
- select_default(d.leg2).attr("stroke-opacity", lineopacity);
287
- }).on("mousedown", (event) => {
288
- event.stopPropagation();
289
- }).on("mousemove", (event) => {
290
- event.stopPropagation();
291
- }).on("click", (event, d) => {
292
- tk.hovertip.hide();
293
- const p = event.target.getBoundingClientRect();
294
- tk.itemtip.clear().show(p.left + p.width, p.top - 50);
295
- showOneJunction(d, tk, tk.itemtip.d.append("div"), block, true);
296
- });
297
- doForceLayout(tk, block, viewpxwidth).then(() => {
298
- set_all(tk);
299
- axisstyle({
300
- axis: tk.sections.jug.axis.transition().call(
301
- axisRight().scale(tk.sections.jug.yscale).ticks(Math.floor(tk.sections.jug.axisheight / 20), ".0f")
302
- ),
303
- color: "black",
304
- showline: true
305
- });
306
- });
307
- }
308
- function rawdata2track(raw, tk, block) {
309
- const viewpxwidth = block.width + block.subpanels.reduce((i, j) => i + j.leftpad + j.width, 0);
310
- const junctions = [];
311
- for (const j of raw) {
312
- if (j.sv && j.chr == j.sv.mate.chr) {
313
- if (j.start > j.sv.mate.start) {
314
- const p = j.start;
315
- j.start = j.stop = j.sv.mate.start;
316
- j.sv.mate.start = j.sv.mate.stop = p;
317
- const q = j.strand;
318
- j.strand = j.sv.mate.strand;
319
- j.sv.mate.strand = q;
320
- }
321
- }
322
- const e = j2block(j, block, viewpxwidth);
323
- if (e) {
324
- console.log(
325
- "junction not in view range: " + j.chr + ":" + j.start + "-" + (j.sv ? j.sv.mate.chr + ":" + j.sv.mate.start : j.stop)
326
- );
327
- continue;
328
- }
329
- junctions.push(j);
330
- }
331
- if (tk.data) {
332
- const map = /* @__PURE__ */ new Map();
333
- tk.data.forEach((j) => map.set(j.chr + "." + j.start + "." + j.stop + "." + j.strand, j));
334
- const pannedpx = Number.isInteger(block.pannedpx) ? block.pannedpx : 0;
335
- for (const i of junctions) {
336
- const j = map.get(i.chr + "." + i.start + "." + i.stop + "." + i.strand);
337
- if (j) {
338
- i.x = j.x + pannedpx;
339
- i.axisy = j.axisy;
340
- }
341
- }
342
- }
343
- if (junctions.length == 0) {
344
- return "no junctions in view range";
345
- }
346
- tk.data = junctions;
347
- }
348
- function j2block(j, block, viewpxwidth) {
349
- let starthit;
350
- let stophit;
351
- {
352
- const l = block.seekcoord(j.chr, j.start);
353
- for (const hit of l) {
354
- if (hit.ridx != void 0 && block.subpanels) {
355
- if (hit.x < 0 || hit.x > block.width) {
356
- continue;
357
- }
358
- }
359
- starthit = hit;
360
- }
361
- }
362
- {
363
- const l = block.seekcoord(j.sv ? j.sv.mate.chr : j.chr, j.sv ? j.sv.mate.start : j.stop);
364
- for (const hit of l) {
365
- if (hit.ridx != void 0 && block.subpanels) {
366
- if (hit.x < 0 || hit.x > block.width) {
367
- continue;
368
- }
369
- }
370
- stophit = hit;
371
- }
372
- }
373
- if (starthit) {
374
- if (!stophit) {
375
- stophit = starthit;
376
- }
377
- } else {
378
- if (stophit) {
379
- starthit = stophit;
380
- } else {
381
- return true;
382
- }
383
- }
384
- let startout = starthit.x < 0 || starthit.x > viewpxwidth;
385
- let stopout = stophit.x < 0 || stophit.x > viewpxwidth;
386
- if (startout && stopout) {
387
- return true;
388
- }
389
- j.x0 = starthit.x;
390
- j.x1 = stophit.x;
391
- j.x = (j.x0 + j.x1) / 2;
392
- j._x = j.x;
393
- return false;
394
- }
395
- function setColor(tk) {
396
- for (const j of tk.data) {
397
- delete j.color;
398
- j.color = JTypes[j.types[0]]?.color;
399
- if (j.color == void 0) throw new Error("unknown j.type");
400
- }
401
- }
402
- function set_jug(d) {
403
- return "translate(" + d.x + ",0)";
404
- }
405
- function set_leg_x1(d) {
406
- return d.x0 - d.x;
407
- }
408
- function set_leg_x2(d) {
409
- return d.x1 - d.x;
410
- }
411
- function set_jug2(d, tk) {
412
- return "translate(0,-" + (tk.sections.jug.legheight + tk.sections.jug.neckheight + d.axisy) + ")";
413
- }
414
- function set_all(tk) {
415
- const mg = tk.sections.jug;
416
- tk.data.forEach((j) => j.axisy = mg.axisheight - mg.yscale(j.medianReadCount));
417
- const dur = 500;
418
- mg.g.selectAll(".sja_jug_leg1").transition().duration(dur).attr("y2", -mg.legheight).attr("x1", (d) => set_leg_x1(d));
419
- mg.g.selectAll(".sja_jug_leg2").transition().duration(dur).attr("y1", -mg.legheight).attr("x2", (d) => set_leg_x2(d));
420
- mg.g.selectAll(".sja_jug_jug2").transition().duration(dur).attr("transform", (d) => set_jug2(d, tk));
421
- mg.g.selectAll(".sja_jug").transition().duration(dur).attr("transform", (d) => set_jug(d));
422
- mg.g.selectAll(".sja_jug_stem").transition().duration(dur).attr("y2", (d) => mg.neckheight + d.axisy);
423
- }
424
- function doForceLayout(tk, block, viewpxwidth) {
425
- const nodes = [];
426
- let sumdiscwidth = 0;
427
- tk.data.map((j) => {
428
- let tox;
429
- if (j.x0 < 0) {
430
- tox = j.x1 - j.radius2 * 2;
431
- } else if (j.x1 > viewpxwidth) {
432
- tox = j.x0 + j.radius2 * 2;
433
- } else {
434
- tox = j._x;
435
- }
436
- nodes.push({
437
- junction: j,
438
- tox,
439
- x: tox,
440
- y: tk.sections.jug.axisheight - tk.sections.jug.yscale(j.medianReadCount)
441
- });
442
- sumdiscwidth += j.radius2 * 2;
443
- });
444
- nodes.sort((i, j) => i.tox - j.tox);
445
- nodes.forEach((n, i) => n.index = i);
446
- const collidestrength = sumdiscwidth <= viewpxwidth ? 1 : viewpxwidth / sumdiscwidth;
447
- return new Promise((resolve, reject) => {
448
- simulation_default(nodes).force(
449
- "y",
450
- y_default((d) => {
451
- return tk.sections.jug.axisheight - tk.sections.jug.yscale(d.junction.medianReadCount);
452
- }).strength(1)
453
- ).force("x", x_default((d) => d.tox).strength(0.1)).force(
454
- "collide",
455
- collide_default((d) => {
456
- return d.junction.radius2 + 2;
457
- }).strength(collidestrength)
458
- ).alphaMin(0.5).on("end", () => {
459
- nodes.forEach((n) => {
460
- n.junction.x = n.x;
461
- });
462
- resolve();
463
- });
464
- });
465
- }
466
- function mouseoverSpanBackground(j, tk, block, viewpxwidth) {
467
- let xleft = Math.min(j.x0, j.x1);
468
- let xright = Math.max(j.x0, j.x1);
469
- if (block.usegm && block.usegm.strand == "-") {
470
- xleft = j.x1;
471
- xright = j.x0;
472
- }
473
- if (xleft >= 0 && xright <= viewpxwidth) {
474
- block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xleft).attr("y", 0).attr("width", xright - xleft).attr("height", block.totalheight()).attr("fill", "url(#" + tk.gradient4spanBackground.mid.id + ")");
475
- return;
476
- }
477
- const boxwidth = 50;
478
- if (xleft >= 0) {
479
- block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xleft).attr("fill", "url(#" + tk.gradient4spanBackground.left.id + ")");
480
- } else {
481
- block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xright - boxwidth).attr("fill", "url(#" + tk.gradient4spanBackground.right.id + ")");
482
- }
483
- block.cursorhlbar.attr("y", 0).attr("width", boxwidth).attr("height", block.totalheight());
484
- }
485
- function mouseoverBoxplot(j, tk) {
486
- if (!j.readcountBoxplot) return;
487
- const color = "black";
488
- const p5 = tk.sections.jug.yscale(j.readcountBoxplot[0]);
489
- const p25 = tk.sections.jug.yscale(j.readcountBoxplot[1]);
490
- const p50 = tk.sections.jug.yscale(j.readcountBoxplot[2]);
491
- const p75 = tk.sections.jug.yscale(j.readcountBoxplot[3]);
492
- const p95 = tk.sections.jug.yscale(j.readcountBoxplot[4]);
493
- const w = 10;
494
- tk.pica.g.selectAll("*").remove();
495
- tk.pica.g.attr("transform", "translate(" + j.x + "," + p50 + ")");
496
- const g = tk.pica.g.append("g").attr("transform", "translate(" + (-5 - w - j.radius2) + ",0)");
497
- g.append("line").attr("x1", w / 2).attr("x2", w / 2).attr("y1", p95 - p50).attr("y2", p5 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
498
- g.append("line").attr("x1", 0).attr("x2", w).attr("y1", p5 - p50).attr("y2", p5 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
499
- g.append("line").attr("x1", 0).attr("x2", w).attr("y1", p95 - p50).attr("y2", p95 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
500
- g.append("rect").attr("y", p75 - p50).attr("width", w).attr("height", p25 - p75).attr("stroke", color).attr("fill", "white").attr("shape-rendering", "crispEdges");
501
- if (p25 - p75 > 3) {
502
- g.append("line").attr("x2", w).attr("stroke", color).attr("shape-rendering", "crispEdges");
503
- }
504
- }
505
- function showOneJunction(j, tk, holder, block, isClickMenu = false) {
506
- const table = table2col({ holder, margin: "0px" });
507
- {
508
- const [t12, t22] = table.addRow();
509
- t12.text("Junction");
510
- const div = t22.append("div");
511
- if (!j.sv || j.chr == j.sv.mate.chr) {
512
- div.html(
513
- bplen(Math.abs(j.start - (j.sv ? j.sv.mate.start : j.stop))) + ' <span style="font-size:.8em;">' + j.chr + ":" + (j.start + 1) + "-" + ((j.sv ? j.sv.mate.start : j.stop) + 1) + "</span>"
514
- );
515
- } else {
516
- div.html(
517
- '<span style="font-size:.8em;">' + j.chr + ":" + (j.start + 1) + "-" + j.sv.mate.chr + ":" + (j.sv.mate.start + 1) + "</span>"
518
- );
519
- }
520
- const d2 = t22.append("div");
521
- d2.append("span").attr("class", "sja_mcdot").style("padding", "1px 5px").style("background-color", "#555").style("margin-right", "5px").text(j.strand);
522
- if (j.info.site) {
523
- d2.append("span").style("font-size", ".7em").style("margin-right", "5px").text(j.info.site);
524
- }
525
- for (const t of j.types) {
526
- d2.append("span").attr("class", "sja_mcdot").style("padding", "1px 5px").style("background-color", JTypes[t]?.color || "black").style("margin-right", "5px").text(JTypes[t]?.name || "?");
527
- }
528
- }
529
- const [t1, t2] = table.addRow();
530
- if (j.sampleCount == 1) {
531
- t1.text("Sample");
532
- const sndiv = t2.append("div");
533
- sndiv.text(j.sampleName || "single sample");
534
- t2.append("div").html(j.medianReadCount + ' <span style="font-size:.7em">read count</span>');
535
- } else {
536
- t1.text("Samples");
537
- t2.append("div").html(`${j.sampleCount} <span style="font-size:.7em">samples</span>
538
- <br>${j.medianReadCount} <span style="font-size:.7em">median read count</span>`);
539
- }
540
- if (isClickMenu && tk.massApp) {
541
- const [, buttonCell] = table.addRow();
542
- buttonCell.append("button").attr("data-testid", "sjpp-junction-details").text("Details").on("click", async () => {
543
- tk.itemtip.hide();
544
- await tk.massApp.dispatch({
545
- type: "plot_create",
546
- config: {
547
- chartType: "summary",
548
- term: { term: makeJunctionTerm(j), q: { mode: "continuous" } }
549
- }
550
- });
551
- });
552
- buttonCell.append("button").attr("data-testid", "sjpp-junction-select").text("Select").on("click", async (event) => {
553
- await addJunctionCustomTerm(tk, [makeJunctionTerm(j)], event.currentTarget, msgDiv);
554
- });
555
- const msgDiv = buttonCell.append("div").style("font-size", ".7em");
556
- }
557
- const type2elst = /* @__PURE__ */ new Map();
558
- for (const e of j.info?.events || []) {
559
- if (!type2elst.has(e.type)) type2elst.set(e.type, []);
560
- type2elst.get(e.type).push(e);
561
- }
562
- for (const [type, elst] of type2elst) {
563
- listAllEvents(elst, table, j, tk, block, isClickMenu);
564
- }
565
- if (type2elst.size == 0) {
566
- const [t12, t22] = table.addRow();
567
- t12.text("Diagram");
568
- showJunctionDiagram(j, tk, t22);
569
- }
570
- }
571
- function makeJunctionTerm(j) {
572
- const position = `${j.chr}:${j.start + 1}-${j.stop + 1}`;
573
- return {
574
- type: TermTypes.JUNCTION,
575
- id: `${j.chr}:${j.start}-${j.stop}:${j.strand}`,
576
- name: j.name || `${position} (${j.strand})`,
577
- chr: j.chr,
578
- start: j.start,
579
- stop: j.stop,
580
- strand: j.strand,
581
- info: j.info || {}
582
- };
583
- }
584
- function showJunctionDiagram(j, tk, holder) {
585
- if (typeof j.info != "object" || Object.keys(j.info).length == 0) {
586
- return;
587
- }
588
- const leftgenes = /* @__PURE__ */ new Map();
589
- if (j.info.exonleft) j.info.exonleft.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
590
- if (j.info.exonleftin) j.info.exonleftin.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
591
- if (j.info.intronleft) j.info.intronleft.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
592
- const rightgenes = /* @__PURE__ */ new Map();
593
- if (j.info.exonright) j.info.exonright.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
594
- if (j.info.exonrightin) j.info.exonrightin.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
595
- if (j.info.intronright) j.info.intronright.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
596
- let isoform;
597
- let strand;
598
- if (leftgenes.size) {
599
- if (rightgenes.size) {
600
- for (const [n, a] of leftgenes) {
601
- if (rightgenes.has(n)) {
602
- isoform = n;
603
- strand = a.strand;
604
- break;
605
- }
606
- }
607
- } else {
608
- const a = [...leftgenes][0];
609
- isoform = a[0];
610
- strand = a[1].strand;
611
- }
612
- } else if (rightgenes.size) {
613
- const a = [...rightgenes][0];
614
- isoform = a[0];
615
- strand = a[1].strand;
616
- }
617
- if (isoform) {
618
- if (strand != "+" && strand != "-") {
619
- holder.text("unknown strand for " + isoform);
620
- return;
621
- }
622
- import("./spliceevent.noeventdiagram-ZO6R3776.js").then((p) => {
623
- p.samegene({
624
- isoform,
625
- reverse: strand == "-",
626
- ongene: j.info,
627
- holder
628
- });
629
- });
630
- return;
631
- }
632
- import("./spliceevent.noeventdiagram-ZO6R3776.js").then((p) => {
633
- p.differentgenes({
634
- ongene: j.info,
635
- holder
636
- });
637
- });
638
- }
639
- function showEventdiagram_a53ss(j, e, tk, holder, block, isClickMenu) {
640
- const e2 = {
641
- junctionB: {
642
- start: j.start,
643
- stop: j.stop,
644
- strand: j.strand,
645
- v: j.medianReadCount
646
- },
647
- a5ss: e.type == JT_a5ss,
648
- a3ss: e.type == JT_a3ss,
649
- altinintron: e.altinintron,
650
- altinexon: e.altinexon,
651
- frame: e.frame,
652
- exon5idx: e.exon5idx,
653
- strand: e.strand,
654
- sitedist: e.sitedist
655
- };
656
- const otherJs = [];
657
- if (e.junctionA) {
658
- e2.junctionA = { start: e.junctionA.start, stop: e.junctionA.stop, strand: e.junctionA.strand, v: "..." };
659
- const aj = structuredClone(e.junctionA);
660
- aj.name = `E${e.exon5idx + 1}-E${e.exon5idx + 1 + 1}`;
661
- otherJs.push(aj);
662
- }
663
- if (isClickMenu) {
664
- mayGroupSelect(tk, block, j, otherJs, `${e.gene} ${e.isoform} E${e.exon5idx + 1} ${e.type}`, holder);
665
- }
666
- import("./spliceevent.a53ss.diagram-C32IEFMU.js").then((p) => {
667
- const text = p.default({
668
- event: e2,
669
- holder
670
- });
671
- if (!text) return;
672
- setTimeout(() => {
673
- if (text.node().getBoundingClientRect().top == 0) return;
674
- const strandA = e.junctionA.strand;
675
- fetchReadcount4junctionAbyjunctionBsamples(
676
- tk,
677
- block,
678
- j,
679
- /* @__PURE__ */ new Map([[e.junctionA.start + "." + e.junctionA.stop + "." + strandA, text]]),
680
- [[e.junctionA.start, e.junctionA.stop, strandA]]
681
- );
682
- }, 1e3);
683
- });
684
- }
685
- function showEventdiagram_skipalt_fetchreadcount(j, e, tk, holder, block, isClickMenu) {
686
- const e2 = {
687
- gm: {
688
- // confirm if can delete
689
- name: e.gene,
690
- isoform: e.isoform
691
- },
692
- junctionB: {
693
- data: [{ v: j.medianReadCount }]
694
- },
695
- skippedexon: e.skippedexon,
696
- isskipexon: e.type == JT_exonskip,
697
- isaltexon: e.type == JT_exonaltuse,
698
- frame: e.frame,
699
- junctionAlst: [],
700
- color: "#99004d"
701
- };
702
- const otherJs = [];
703
- const firstSkipped = Math.min(...e.skippedexon) + 1;
704
- const lastSkipped = Math.max(...e.skippedexon) + 1;
705
- if (e.junctionAlst) {
706
- for (const [i, jA] of e.junctionAlst.entries()) {
707
- if (jA) {
708
- const aj = structuredClone(jA);
709
- aj.name = `E${firstSkipped - 1 + i}-E${firstSkipped + i}`;
710
- otherJs.push(aj);
711
- jA.data = [{ v: "..." }];
712
- e2.junctionAlst.push(jA);
713
- continue;
714
- }
715
- e2.junctionAlst.push(null);
716
- }
717
- }
718
- if (e.up1junction) {
719
- const uj = structuredClone(e.up1junction);
720
- uj.name = `E${firstSkipped - 2}-E${firstSkipped - 1}`;
721
- otherJs.push(uj);
722
- e.up1junction.data = [{ v: "..." }];
723
- e2.up1junction = e.up1junction;
724
- }
725
- if (e.down1junction) {
726
- const dj = structuredClone(e.down1junction);
727
- dj.name = `E${lastSkipped + 1}-E${lastSkipped + 2}`;
728
- otherJs.push(dj);
729
- e.down1junction.data = [{ v: "..." }];
730
- e2.down1junction = e.down1junction;
731
- }
732
- if (isClickMenu) {
733
- const jc = structuredClone({
734
- // duplicate j.info{} just in case
735
- chr: j.chr,
736
- start: j.start,
737
- stop: j.stop,
738
- strand: j.strand,
739
- info: j.info
740
- });
741
- jc.name = `E${firstSkipped - 1}-E${lastSkipped + 1}`;
742
- mayGroupSelect(
743
- tk,
744
- block,
745
- jc,
746
- otherJs,
747
- `${e.gene} ${e.isoform} ${e.skippedexon.map((i) => "E" + (i + 1)).join(",")} ${e.type}`,
748
- holder
749
- );
750
- }
751
- import("./spliceevent.exonskip.diagram-CZ7MVRLK.js").then((p) => {
752
- const [junction2readcounttext, junctionlst] = p.default({
753
- event: e2,
754
- holder,
755
- nophrase: true
756
- });
757
- setTimeout(() => {
758
- for (const [k, text] of junction2readcounttext) {
759
- if (text.node().getBoundingClientRect().top == 0) {
760
- return;
761
- }
762
- }
763
- fetchReadcount4junctionAbyjunctionBsamples(tk, block, j, junction2readcounttext, junctionlst);
764
- }, 1e3);
765
- });
766
- }
767
- function mayGroupSelect(tk, block, mainJ, otherJs, eventlabel, holder) {
768
- if (!tk.massApp) return;
769
- for (const j of otherJs) {
770
- j.chr = mainJ.chr;
771
- j.info = {
772
- type: JT_canonical
773
- };
774
- }
775
- holder.append("button").attr("data-testid", "sjpp-junction-select").text(`Select ${otherJs.length + 1} junctions`).on("click", async (event) => {
776
- await addJunctionCustomTerm(
777
- tk,
778
- [makeJunctionTerm(mainJ), ...otherJs.map(makeJunctionTerm)],
779
- event.currentTarget,
780
- msgDiv,
781
- eventlabel
782
- );
783
- });
784
- const msgDiv = holder.append("div").style("font-size", ".7em");
785
- }
786
- async function addJunctionCustomTerm(tk, junctions, button, msgDiv, eventlabel) {
787
- await tk.massApp.dispatch({
788
- type: "add_customTerm",
789
- obj: makeJunctionCustomTerm(junctions, eventlabel)
790
- });
791
- button.remove();
792
- msgDiv.text(
793
- eventlabel ? `${junctions.length} junctions can now be found through variable selection under ${eventlabel}.` : "This junction can now be found through variable selection."
794
- );
795
- }
796
- function listAllEvents(lst, table, j, tk, block, isClickMenu) {
797
- if (lst.length == 1) {
798
- const [t1, t2] = table.addRow();
799
- const e = lst[0];
800
- t1.append("div").text(e.gene);
801
- t1.append("div").text(e.isoform).style("font-size", ".8em");
802
- if (e.type == JT_exonskip || e.type == JT_exonaltuse) {
803
- showEventdiagram_skipalt_fetchreadcount(j, e, tk, t2, block, isClickMenu);
804
- } else if (e.type == JT_a5ss || e.type == JT_a3ss) {
805
- showEventdiagram_a53ss(j, e, tk, t2, block, isClickMenu);
806
- }
807
- return;
808
- }
809
- const map = /* @__PURE__ */ new Map();
810
- for (const e of lst) {
811
- const f = structuredClone(e);
812
- const v = e.isoform;
813
- delete f.isoform;
814
- const key = JSON.stringify(f);
815
- if (map.has(key)) map.get(key).push(e.isoform);
816
- else map.set(key, [e.isoform]);
817
- }
818
- for (const [key, isolst] of map) {
819
- const eo = JSON.parse(key);
820
- eo.isoform = isolst[0];
821
- const [t1, t2] = table.addRow();
822
- t1.append("div").text(eo.gene);
823
- {
824
- const s = isolst.length >= 5 ? 0.7 : 0.8;
825
- for (const i of isolst)
826
- t1.append("div").text(i).style("font-size", s + "em");
827
- }
828
- if (eo.type == JT_exonskip || eo.type == JT_exonaltuse) {
829
- showEventdiagram_skipalt_fetchreadcount(j, eo, tk, t2, block, isClickMenu);
830
- } else if (eo.type == JT_a5ss || eo.type == JT_a3ss) {
831
- showEventdiagram_a53ss(j, eo, tk, t2, block, isClickMenu);
832
- }
833
- }
834
- }
835
- async function fetchReadcount4junctionAbyjunctionBsamples(tk, block, jB, junction2readcounttext, jAlst) {
836
- const [body, headers] = getParameter(tk, block);
837
- delete body.rglst;
838
- delete body.hiddenTypes;
839
- body.junctionB = { chr: jB.chr, start: jB.start, stop: jB.stop, strand: jB.strand };
840
- body.junctionAposlst = jAlst;
841
- try {
842
- const data = await dofetch3("termdb/junctions/AbyB", { body, headers });
843
- if (data.error) throw new Error(data.error);
844
- if (!Array.isArray(data.lst)) throw new Error(".lst[] missing");
845
- for (const j of data.lst) {
846
- const key = j.start + "." + j.stop + "." + j.strand;
847
- if (junction2readcounttext.has(key)) {
848
- junction2readcounttext.get(key).text(j.v);
849
- }
850
- }
851
- } catch (e) {
852
- console.error(e.message || e);
853
- }
854
- }
855
-
856
- // j2/makeTk.js
857
- async function makeTk(tk, block) {
858
- if ("yscaleUseLog" in tk) {
859
- if (typeof tk.yscaleUseLog != "boolean") throw new Error("tk.yscaleUseLog not boolean");
860
- } else {
861
- tk.yscaleUseLog = true;
862
- }
863
- if (tk.hiddentypes) {
864
- if (typeof tk.hiddentypes != "string") throw new Error("tk.hiddentypes not string");
865
- }
866
- if (tk.readcountCutoff) {
867
- if (!Number.isInteger(tk.readcountCutoff) || tk.readcountCutoff < 0)
868
- throw new Error("tk.readcountCutoff is not positive integer");
869
- } else {
870
- tk.readcountCutoff = 0;
871
- }
872
- {
873
- const pale = "#FFFEAB";
874
- const dark = "#F7F69E";
875
- const id1 = Math.random().toString();
876
- const id2 = Math.random().toString();
877
- const id3 = Math.random().toString();
878
- const defs = tk.gleft.append("defs");
879
- const left = defs.append("linearGradient").attr("id", id1);
880
- left.append("stop").attr("offset", 0).attr("stop-color", dark);
881
- left.append("stop").attr("offset", 1).attr("stop-color", "white");
882
- const mid = defs.append("linearGradient").attr("id", id2);
883
- mid.append("stop").attr("offset", 0).attr("stop-color", pale);
884
- mid.append("stop").attr("offset", 0.5).attr("stop-color", "white");
885
- mid.append("stop").attr("offset", 1).attr("stop-color", pale);
886
- const right = defs.append("linearGradient").attr("id", id3);
887
- right.append("stop").attr("offset", 0).attr("stop-color", "white");
888
- right.append("stop").attr("offset", 1).attr("stop-color", dark);
889
- tk.gradient4spanBackground = {
890
- left: { id: id1, gradient: left },
891
- mid: { id: id2, gradient: mid },
892
- right: { id: id3, gradient: right }
893
- };
894
- }
895
- tk.leftlabels = {
896
- // all labels are rendered here, except track label
897
- g: tk.gleft.append("g").attr("transform", "translate(0,17)"),
898
- doms: {},
899
- // keys: label name, value: label dom
900
- // to avoid having to delete all labels upon tk rendering
901
- laby: 0,
902
- // cumulative height, 0 for no labels
903
- xoff: 0,
904
- maxwidth: 0
905
- // set default 0 in case track runs into err, can still render tk
906
- };
907
- tk.leftlabels.doms.jug = makelabel(tk, block, 0);
908
- {
909
- const g = tk.glider.append("g");
910
- tk.sections = {
911
- // sections from top to bottom.
912
- jug: {
913
- height: 0,
914
- // total height of the jug section
915
- g: g.append("g"),
916
- axis: g.append("g")
917
- }
918
- };
919
- }
920
- setH(tk, "axisheight", 200);
921
- setH(tk, "legheight", 50);
922
- setH(tk, "neckheight", 50);
923
- tk._finish = loadTk_finish_closure(tk, block);
924
- tk.hovertip = new Menu();
925
- tk.itemtip = new Menu();
926
- tk.menutip = new Menu({ padding: "" });
927
- tk.load = _load(tk, block);
928
- await initTermdb(tk, block);
929
- if (tk.filter) await Promise.all(rehydrateFilter(tk.filter, tk.vocabApi));
930
- tk.tklabel.text(tk.dslabel || tk.name);
931
- tk.clear = () => {
932
- tk.sections.jug.g.selectAll("*").remove();
933
- };
934
- tk.config_handle = block.maketkconfighandle(tk).on("click", () => {
935
- configPanel(tk, block);
936
- });
937
- initLegend(tk, block);
938
- }
939
- function setH(tk, prop, v) {
940
- const customv = tk[prop];
941
- if (customv != void 0) {
942
- if (!Number.isFinite(customv) || customv <= 0) throw new Error("invalid tk." + prop);
943
- tk.sections.jug[prop] = customv;
944
- delete tk[prop];
945
- return;
946
- }
947
- tk.sections.jug[prop] = v;
948
- }
949
- function loadTk_finish_closure(tk, block) {
950
- return (data) => {
951
- tk.legend?.headTd.text(tk.dslabel + (tk.filter ? " - " + getFilterName(tk.filter) : ""));
952
- if (data) {
953
- if (data.error) {
954
- tk.sections.jug.height = 40;
955
- } else {
956
- if (data.junctions?.length == 0) {
957
- tk.sections.jug.g.selectAll("*").remove();
958
- tk.sections.jug.axis.selectAll("*").remove();
959
- tk.sections.jug.g.transition().attr("transform", "translate(0,0)");
960
- tk.sections.jug.g.append("text").text("No splice junctions").attr("y", 25).attr("x", block.width / 2).attr("text-anchor", "middle").attr("dominant-baseline", "center");
961
- tk.sections.jug.height = 40;
962
- }
963
- if (data.alert) {
964
- console.log("TODO print this alert in tk", data.alert);
965
- }
966
- }
967
- }
968
- tk.height_main = tk.sections.jug.height + tk.toppad + tk.bottompad;
969
- if (data) {
970
- updateLegend(data, tk, block);
971
- }
972
- ;
973
- tk.leftLabelMaxwidth = tk.leftlabels.maxwidth + tk.leftlabels.xoff, block.tkcloakoff(tk, { error: data ? data.error : null });
974
- block.block_setheight();
975
- block.setllabel();
976
- tk.callbackOnRender?.(tk, block);
977
- };
978
- }
979
- async function initTermdb(tk, block) {
980
- if (!tk.dslabel) {
981
- throw new Error("tk.dslabel missing");
982
- }
983
- if (!tk.vocabApi) {
984
- const arg = {
985
- vocab: {
986
- genome: block.genome.name,
987
- dslabel: tk.dslabel
988
- }
989
- };
990
- const _ = await import("./vocabulary-BR4NJDPS.js");
991
- tk.vocabApi = _.vocabInit(arg);
992
- if (!tk.vocabApi.app) {
993
- tk.vocabApi.app = { opts: { genome: block.genome } };
994
- }
995
- }
996
- if (!tk.termdbConfig) {
997
- tk.termdbConfig = await tk.vocabApi.getTermdbConfig();
998
- }
999
- if (!tk.termdbConfig.queries?.junction) throw new Error("queries.junction missing");
1000
- }
1001
- function _load(tk, block) {
1002
- return async () => {
1003
- return await loadTk(tk, block);
1004
- };
1005
- }
1006
- function configPanel(tk, block) {
1007
- tk.tkconfigtip.clear().showunder(tk.config_handle.node());
1008
- const holder = tk.tkconfigtip.d;
1009
- {
1010
- const row = holder.append("div").style("margin-bottom", "15px");
1011
- row.append("span").html("Read count cutoff&nbsp;");
1012
- row.append("input").property("value", tk.readcountCutoff || 0).attr("type", "number").style("width", "50px").on("keyup", (event) => {
1013
- if (event.code != "Enter" && event.code != "NumpadEnter") return;
1014
- let v = Number(event.target.value);
1015
- if (!v || v < 0) {
1016
- v = 0;
1017
- }
1018
- if (v == 0) {
1019
- if (tk.readcountCutoff) {
1020
- tk.readcountCutoff = 0;
1021
- loadTk(tk, block, true);
1022
- } else {
1023
- }
1024
- return;
1025
- }
1026
- if (tk.readcountCutoff) {
1027
- if (tk.readcountCutoff == v) {
1028
- } else {
1029
- tk.readcountCutoff = v;
1030
- loadTk(tk, block, true);
1031
- }
1032
- } else {
1033
- tk.readcountCutoff = v;
1034
- loadTk(tk, block, true);
1035
- }
1036
- });
1037
- row.append("div").style("font-size", ".7em").style("color", "#858585").text("For a junction, samples with read count lower than cutoff will not be shown.");
1038
- }
1039
- {
1040
- const k = tk.sections.jug;
1041
- const row = holder.append("div").style("margin-bottom", "15px");
1042
- row.append("span").text("Track height");
1043
- row.append("button").html("&nbsp;&nbsp;+&nbsp;&nbsp;").style("margin-left", "10px").on("click", () => {
1044
- k.axisheight += 30;
1045
- k.legheight = k.axisheight / 4;
1046
- renderTk(null, tk, block);
1047
- block.block_setheight();
1048
- });
1049
- row.append("button").html("&nbsp;&nbsp;-&nbsp;&nbsp;").style("margin-left", "5px").on("click", () => {
1050
- if (k.axisheight <= 90) return;
1051
- k.axisheight -= 30;
1052
- k.legheight = k.axisheight / 4;
1053
- renderTk(null, tk, block);
1054
- block.block_setheight();
1055
- });
1056
- }
1057
- {
1058
- const row = holder.append("div").style("margin-bottom", "1px");
1059
- const id = Math.random();
1060
- const input = row.append("input").attr("type", "checkbox").style("margin-right", "10px").attr("id", id).on("change", () => {
1061
- tk.yscaleUseLog = !tk.yscaleUseLog;
1062
- renderTk(null, tk, block);
1063
- });
1064
- if (tk.yscaleUseLog) {
1065
- input.property("checked", 1);
1066
- }
1067
- row.append("label").text("Use log10 for Y scale read count").attr("for", id);
1068
- }
1069
- }
1070
-
1071
- // j2/tk.js
1072
- async function loadTk(tk, block) {
1073
- block.tkcloakon(tk);
1074
- block.block_setheight();
1075
- try {
1076
- if (tk.uninitialized) {
1077
- await makeTk(tk, block);
1078
- delete tk.uninitialized;
1079
- }
1080
- const data = await getTkData(tk, block);
1081
- renderTk(data, tk, block);
1082
- tk._finish(data);
1083
- } catch (e) {
1084
- if (tk.clear) tk.clear();
1085
- if (tk._finish) tk._finish({ error: e.message || e });
1086
- if (e.stack) console.log(e.stack);
1087
- }
1088
- }
1089
- function getParameter(tk, block) {
1090
- const par = {
1091
- genome: block.genome.name,
1092
- dslabel: tk.dslabel,
1093
- filter0: tk.filter0,
1094
- filter: tk.filter,
1095
- readcountCutoff: tk.readcountCutoff
1096
- };
1097
- const headers = { "Content-Type": "application/json", Accept: "application/json" };
1098
- rangequery_rglst(tk, block, par);
1099
- if (tk.legend?.type?.hiddenvalues?.size) par.hiddenTypes = [...tk.legend.type.hiddenvalues].join(",");
1100
- return [par, headers];
1101
- }
1102
- async function getTkData(tk, block) {
1103
- let data;
1104
- if (tk.custom_data) {
1105
- data = await dataFromCustomData(tk, block);
1106
- } else {
1107
- const [body, headers] = getParameter(tk, block);
1108
- data = await dofetch3("termdb/junctions", { body, headers });
1109
- }
1110
- if (data.error) throw new Error(data.error);
1111
- return data;
1112
- }
1113
- async function dataFromCustomData(tk, block) {
1114
- const data = [];
1115
- return data;
1116
- }
1117
- export {
1118
- getParameter,
1119
- loadTk
1120
- };
1121
- //# sourceMappingURL=tk-ONKYBG6R.js.map