@sjcrh/proteinpaint-client 2.206.0 → 2.207.0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/dist/2dmaf-5JKVMAPO.js +1367 -0
- package/dist/AggMatrixInput-254IEQYB.js +277 -0
- package/dist/AggregateMatrix-U3NZSNL6.js +41 -0
- package/dist/AppHeader-DK2GIYYT.js +830 -0
- package/dist/BoxPlot-POSL2ZLS.js +1211 -0
- package/dist/CorrelationVolcano-YZ6ACP5D.js +614 -0
- package/dist/Cuminc-SJVFK4VX.js +1219 -0
- package/dist/DE-RJMZGJ5Y.js +89 -0
- package/dist/DEinput-H25PS4QT.js +499 -0
- package/dist/DM-A3UCF7HM.js +90 -0
- package/dist/DifferentialAnalysis-4J75UMV7.js +237 -0
- package/dist/Disco-IXGGKIEI.js +3389 -0
- package/dist/Disco.UI-X3JG4ERN.js +243 -0
- package/dist/DmrPlot-SJWHTSMB.js +637 -0
- package/dist/GB-KPF7BZFQ.js +1391 -0
- package/dist/GSEA-BMVTJ6B7.js +851 -0
- package/dist/GeneExpInput-3KFGQEAY.js +42 -0
- package/dist/Geomap-R7Q3T3DZ.js +84 -0
- package/dist/HicApp-BTFHMXQE.js +2245 -0
- package/dist/IDCViewer-RVVWT7MH.js +10812 -0
- package/dist/NumBinaryEditor-V3YCDNRR.js +279 -0
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- package/dist/NumContEditor-FSHA32UV.js +105 -0
- package/dist/NumContEditor.unit.spec-5IFB4GXP.js +164 -0
- package/dist/NumCustomBinEditor-63YQZU52.js +33 -0
- package/dist/NumCustomBinEditor.unit.spec-BJLGQQ4R.js +397 -0
- package/dist/NumDiscreteEditor-K4AZ6UQF.js +170 -0
- package/dist/NumDiscreteEditor.unit.spec-AHL7QA4N.js +233 -0
- package/dist/NumRegularBinEditor-5N3PWOIQ.js +33 -0
- package/dist/NumRegularBinEditor.unit.spec-SYPTBY5A.js +278 -0
- package/dist/NumSplineEditor-ZLB5MWYK.js +210 -0
- package/dist/NumSplineEditor.unit.spec-ZLAVLV7E.js +224 -0
- package/dist/NumericDensity-K4CTMN2G.js +33 -0
- package/dist/NumericDensity.unit.spec-BLWEQHZC.js +418 -0
- package/dist/NumericHandler-3KACLCOL.js +34 -0
- package/dist/NumericHandler.unit.spec-4P7HBSCB.js +214 -0
- package/dist/ProteomeInput-JZ6MKE7L.js +388 -0
- package/dist/Regression-QBR2VYHT.js +1416 -0
- package/dist/RunChart2-UKN6M5M5.js +749 -0
- package/dist/SC-COHN7DMJ.js +1107 -0
- package/dist/Violin-SDUSKIEX.js +1082 -0
- package/dist/Volcano-KON4MOIM.js +1649 -0
- package/dist/Wsi-SJC56PRR.js +609 -0
- package/dist/Wsi-SJC56PRR.js.map +7 -0
- package/dist/adSandbox-L6ZHCJJO.js +33 -0
- package/dist/animatedBubbleChart-IQBJBHPP.js +547 -0
- package/dist/app-2NSQK3GQ.js +32 -0
- package/dist/app-GMYTOBRB.js +42 -0
- package/dist/app.js +13 -13
- package/dist/bam-B4ZPOZTX.js +876 -0
- package/dist/barchart-WF5VWDCV.js +42 -0
- package/dist/barchart2-3HGZ5Q2B.js +309 -0
- package/dist/block-A3I2INBA.js +6249 -0
- package/dist/block.init-YUHPWTMF.js +33 -0
- package/dist/block.mds.expressionrank-TGAZQTVW.js +354 -0
- package/dist/block.mds.geneboxplot-GPIQWNWB.js +823 -0
- package/dist/block.mds.junction-YREJCNYJ.js +1539 -0
- package/dist/block.mds.svcnv-2ZDNI2XE.js +6796 -0
- package/dist/block.svg-2BRKZJAO.js +159 -0
- package/dist/block.tk.aicheck-ZDTQFF7Q.js +278 -0
- package/dist/block.tk.ase-JAIOSXZO.js +360 -0
- package/dist/block.tk.bam-V27YBYQG.js +1901 -0
- package/dist/block.tk.bedgraphdot-QFJNEYKU.js +379 -0
- package/dist/block.tk.bigwig.ui-X77XUZLB.js +206 -0
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- package/dist/block.tk.menu-GL6W3MKK.js +1024 -0
- package/dist/block.tk.pgv-T3YW5EGQ.js +938 -0
- package/dist/brainImaging-6WLB6DWG.js +555 -0
- package/dist/brainImaging-6WLB6DWG.js.map +7 -0
- package/dist/brainRegions-EVHXPPL5.js +217 -0
- package/dist/bubbleHeatmap-WZX7MLQF.js +378 -0
- package/dist/cellTypeBubbleHeatmap-3XY3U7EO.js +278 -0
- package/dist/chunk-26VFFI2G.js +1278 -0
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- package/dist/chunk-2XOBD4ZZ.js +102 -0
- package/dist/chunk-5X6CDEMT.js +55 -0
- package/dist/chunk-5X6CDEMT.js.map +7 -0
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- package/dist/chunk-QJQUSRGP.js +134 -0
- package/dist/chunk-RPKZLEY7.js +170 -0
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- package/dist/chunk-UO5AU7IW.js.map +7 -0
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- package/dist/cohort-ZLQA2KPW.js +70 -0
- package/dist/condition-SFZAHMKK.js +327 -0
- package/dist/controls-US3ID2ZR.js +34 -0
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- package/dist/correlation-JD4FMZVF.js +95 -0
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- package/dist/dataDownload-4YQHUJQX.js +329 -0
- package/dist/databrowser.ui-4YE24U4B.js +425 -0
- package/dist/dictionary-LFOSXJGH.js +113 -0
- package/dist/dnaMethylation-2627GIZW.js +33 -0
- package/dist/dnaMethylation.integration.spec-HSZKXED3.js +198 -0
- package/dist/dofetch-7O5UTSGI.js +48 -0
- package/dist/e2pca-XL7F5BK3.js +344 -0
- package/dist/ep-35KADAYG.js +1249 -0
- package/dist/expclust.gdc.spec-TFJEXEAA.js +302 -0
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- package/dist/gb-UIBSH7KV.js +81 -0
- package/dist/geneExpClustering-VYZ5VDPL.js +244 -0
- package/dist/geneExpression-CNBSE3KW.js +33 -0
- package/dist/geneExpression-ECXW22H6.js +310 -0
- package/dist/geneExpression.unit.spec-SCBRU5BG.js +128 -0
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- package/dist/geneORA-BQZ4XYJH.js +273 -0
- package/dist/geneRanking-GXRSXHIN.js +548 -0
- package/dist/geneVariant-Y7GASAY6.js +36 -0
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- package/dist/geneset-HMADFO7Z.js +203 -0
- package/dist/genomeBrowser.spec-3U6KE3MK.js +276 -0
- package/dist/grin2-AJAXI4O4.js +1137 -0
- package/dist/grin2-CFAOAHY3.js +70 -0
- package/dist/hierCluster-JUJ7C7TQ.js +59 -0
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- package/dist/imagePlot-DSG4WJOG.js +156 -0
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- package/dist/isoformExpression-XWLMWXEK.js +35 -0
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- /package/dist/{summaryInput-4IJGKW4P.js.map → summaryInput-TYIKTBO3.js.map} +0 -0
- /package/dist/{sunburst-G7DGATWP.js.map → sunburst-4PA3CO44.js.map} +0 -0
- /package/dist/{survival-MKNABJPU.js.map → survival-GT4CSHX2.js.map} +0 -0
- /package/dist/{survival-IHM6A7LL.js.map → survival-HXJCMNCG.js.map} +0 -0
- /package/dist/{survival.integration.spec-THOKI3DL.js.map → survival.integration.spec-C7OJC4AG.js.map} +0 -0
- /package/dist/{svgraph-VB7JWWR5.js.map → svgraph-MZCOBO4J.js.map} +0 -0
- /package/dist/{svmr-VLQIO2U5.js.map → svmr-FQPAAQHB.js.map} +0 -0
- /package/dist/{table-EAXMDWOY.js.map → table-FKLXVILD.js.map} +0 -0
- /package/dist/{termCollectionFractionSelection-2XZSTDCQ.js.map → termCollection-QDGR6J36.js.map} +0 -0
- /package/dist/{termCollection-5LG7ICQY.js.map → termCollection-Y7CIC6GQ.js.map} +0 -0
- /package/dist/{termCollection.unit.spec-H5ITGTR3.js.map → termCollection.unit.spec-PQMFOWLF.js.map} +0 -0
- /package/dist/{tk-VZI5HNSX.js.map → termCollectionFractionSelection-2O32HROA.js.map} +0 -0
- /package/dist/{termCollectionFractionSelection.unit.spec-BIO7V6KA.js.map → termCollectionFractionSelection.unit.spec-WXGCO2RF.js.map} +0 -0
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- /package/dist/{tk-TRWYZLQ2.js.map → tk-QJNN6WK2.js.map} +0 -0
- /package/dist/{tp.ui-J5SNNAT3.js.map → tp.ui-RI7S54LI.js.map} +0 -0
- /package/dist/{vocabulary-6EADTHP3.js.map → tvs.dt-7CIYMLQF.js.map} +0 -0
- /package/dist/{tvs.dtcnv.categorical-WTIE63GM.js.map → tvs.dtcnv.categorical-D3W6R6BM.js.map} +0 -0
- /package/dist/{tvs.dtcnv.continuous-OCMKGTF5.js.map → tvs.dtcnv.continuous-4WS2TN3K.js.map} +0 -0
- /package/dist/{tvs.dtfusion-CA23UNM3.js.map → tvs.dtfusion-NUUFIGG4.js.map} +0 -0
- /package/dist/{tvs.dtitd-VSYMR3OD.js.map → tvs.dtitd-UCSEWRNJ.js.map} +0 -0
- /package/dist/{tvs.dtsnvindel-YBNO3CYF.js.map → tvs.dtsnvindel-J4S7KU3Y.js.map} +0 -0
- /package/dist/{tvs.dtsv-S743GBB5.js.map → tvs.dtsv-4OPYIWB6.js.map} +0 -0
- /package/dist/{tvs.samplelst-XAJO4EM6.js.map → tvs.samplelst-RUZYZ2FF.js.map} +0 -0
- /package/dist/{tvs.termCollection-QOVJGAUC.js.map → tvs.termCollection-D5X2HNWO.js.map} +0 -0
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vocabInit
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// gdc/geneExpClustering.js
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async function init(arg, holder, genomes) {
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try {
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const useGenome = arg.genome || "hg38";
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const useDslabel = arg.dslabel || "GDC";
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const genome = genomes[useGenome];
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if (!genome) throw useGenome + " missing";
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if (typeof settings != "object") throw "arg.settings{} not object";
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if (!settings.hierCluster) settings.hierCluster = {};
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if (typeof settings.hierCluster != "object") throw "arg.settings.hierCluster{} not object";
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if (!Number.isInteger(settings.hierCluster.maxGenes)) settings.hierCluster.maxGenes = 1e3;
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if (arg.filter0 && typeof arg.filter0 != "object") throw "arg.filter0 not object";
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const vocabApi = await vocabInit({
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state: { vocab: { genome: useGenome, dslabel: useDslabel } }
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});
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vocabApi.getTermdbConfig();
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const plotAppApi = await appInit({
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debug: arg.debug,
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holder: select_default(arg.holder).select(".sja_root_holder"),
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genome,
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state: {
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genome: useGenome,
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dslabel: useDslabel,
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termfilter: { filter0: arg.filter0 },
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plots: [
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// Initialize with a geneset component, in case the genes lst is empty.
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// This will be replaced with the actual matrix/hierCluster app once
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// a valid geneset is selected.
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{
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chartType: "geneset",
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toolName: "Gene Expression Clustering",
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settings: {
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maxGenes: settings.hierCluster.maxGenes
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}
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]
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},
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app: arg.opts?.app || {},
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hierCluster: copyMerge(
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{
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reactsTo(action) {
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if (action.type.startsWith("plot_")) return action.id === this.id;
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if (action.type.startsWith("filter")) return true;
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if (action.type == "app_refresh") return true;
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},
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callbacks: {
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"firstRender.gdcHierCluster": async (hierClusterApi2) => {
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hierClusterApi2.on("firstRender.gdcHierCluster", null);
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if (!genesetCompApi) return;
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plotAppApi.dispatch({
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type: "plot_delete",
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id: genesetCompApi.id
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});
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genesetCompApi = void 0;
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}
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}
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},
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arg.opts?.hierCluster || {}
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),
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matrix: arg.opts?.matrix || {},
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geneset: {
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mode: "geneExpression",
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// consistent with GeneSetEdit
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genome,
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genes: arg.genes,
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showEditUI: arg.opts?.geneset?.showEditUI,
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reactsTo(action) {
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if (action.type.startsWith("plot_")) return action.id === this.id;
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if (action.type.startsWith("filter")) return true;
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if (action.type == "app_refresh") return true;
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},
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showWaitMessage(div) {
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div.style("margin", "20px");
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div.append("div").text("Loading genes that are top variably expressed in current cohort...");
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div.append("div").style("font-size", ".8em").html(`
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Only up to 1000 cases with gene expression data will be used to select genes.<br>
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Genes are selected from all protein-coding genes, may take over 1 minute.
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`);
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},
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async callback(_genesetCompApi, twlst) {
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if (!_genesetCompApi) return;
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genesetCompApi = _genesetCompApi;
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if (!hierClusterApi) {
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const plotConfig = plotAppApi.getState().plots.find((p) => p.chartType == "hierCluster");
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if (plotConfig) hierClusterApi = plotAppApi.getComponents(`plots.${plotConfig.id}`);
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}
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const termgroups = [
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{
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name: "Gene Expression",
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type: "hierCluster",
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lst: twlst
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},
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...arg.termgroups || []
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];
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if (hierClusterApi) {
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plotAppApi.dispatch({
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type: "plot_edit",
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id: hierClusterApi.id,
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config: { termgroups }
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});
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} else {
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plotAppApi.dispatch({
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type: "plot_create",
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config: {
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chartType: "hierCluster",
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// avoid making a dictionary request when there is no gene data;
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// if there is gene data, then the arg.termgroups can be submitted and rehydrated on app/store.init()
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termgroups,
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divideBy: arg.divideBy || void 0,
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// moved default settings to gdc.hg38.js termdb[chartType].settings
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// but can still override in the runpp() argument
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settings,
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dataType: TermTypes.GENE_EXPRESSION
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}
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});
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}
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}
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},
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recover: {
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undoHtml: "Undo",
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redoHtml: "Redo",
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resetHtml: "Restore",
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hide(state) {
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return state.plots[0]?.chartType != "hierCluster";
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},
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adjustTrackedState: (state) => {
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const s = structuredClone(state);
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delete s.termfilter.filter0;
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if (s.plots) {
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for (const plot of s.plots) {
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if (!plot.termgroups) continue;
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for (const grp of plot.termgroups) {
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if (!grp.lst) continue;
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for (const tw of grp.lst) {
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if (!tw?.term) continue;
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delete tw.term.category2samplecount;
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delete tw.term.values;
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}
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}
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}
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}
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return s;
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}
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}
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});
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let hierClusterApi, genesetCompApi;
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const api = {
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type: "hierCluster",
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update: async (_arg) => {
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const plotConfig = plotAppApi.getState().plots.find((p) => p.chartType == "hierCluster");
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if (!hierClusterApi) {
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if (plotConfig) hierClusterApi = plotAppApi.getComponents(`plots.${plotConfig.id}`);
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}
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if (_arg.genes) {
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const t0 = plotConfig.termgroups.find((g) => g.type == "hierCluster");
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plotAppApi.dispatch({
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type: "plot_edit",
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id: hierClusterApi.id,
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config: {
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termgroups: [
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{
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name: t0.name,
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type: "hierCluster",
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lst: await Promise.all(
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_arg.genes.map(async (g) => {
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return await fillTermWrapper(
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{
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term: { gene: g.gene, type: "geneExpression", name: g.gene }
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},
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vocabApi
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);
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})
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)
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}
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]
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}
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});
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} else if ("filter0" in _arg) {
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plotAppApi.dispatch({
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type: "filter_replace",
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filter0: _arg.filter0
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});
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} else if (hierClusterApi) {
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plotAppApi.dispatch({
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id: hierClusterApi.id,
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config: _arg
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});
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}
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},
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triggerAbort: (_) => plotAppApi.triggerAbort(_)
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};
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return api;
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} catch (e) {
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throw e;
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}
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}
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export {
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init
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};
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//# sourceMappingURL=geneExpClustering-3NU2U422.js.map
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import {
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dofetch3
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} from "./chunk-RPDVFM7E.js";
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import "./chunk-M4XXKTH2.js";
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import "./chunk-5ILEFNXJ.js";
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import "./chunk-IZUYLFOX.js";
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import {
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copyMerge,
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getCompInit
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} from "./chunk-WINIL2KN.js";
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import "./chunk-PF4DSFDR.js";
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import "./chunk-W5J3LTYS.js";
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import "./chunk-Z2ZITHT4.js";
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import "./chunk-4OLM3KSB.js";
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import "./chunk-TLT4YIG3.js";
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import "./chunk-5R63Q5KH.js";
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import "./chunk-I6Y4O3RR.js";
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import {
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rgb_default
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import "./chunk-HS5PO5ZQ.js";
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// plots/geneExpression.js
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var defaultConfig = {
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clusterMethod: "average",
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distanceMethod: "euclidean"
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};
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var clusterMethodLst = [
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"average",
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"complete",
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"mcquitty"
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//'single', very slow
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//'median', 'centroid', crashes R with "No connections found!"
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//'ward.D','ward.D2', crashes client
|
|
35
|
-
];
|
|
36
|
-
var distanceMethodLst = ["euclidean", "maximum", "manhattan", "canberra"];
|
|
37
|
-
var GeneExpression = class _GeneExpression {
|
|
38
|
-
static type = "geneExpression";
|
|
39
|
-
constructor() {
|
|
40
|
-
this.type = _GeneExpression.type;
|
|
41
|
-
}
|
|
42
|
-
async init(opts) {
|
|
43
|
-
const holder = this.opts.holder.append("div");
|
|
44
|
-
this.dom = {
|
|
45
|
-
holder,
|
|
46
|
-
controlsDiv: holder.append("div"),
|
|
47
|
-
canvas: holder.append("canvas"),
|
|
48
|
-
colorScaleDiv: holder.append("div")
|
|
49
|
-
};
|
|
50
|
-
this.makeControls();
|
|
51
|
-
this.components = {};
|
|
52
|
-
}
|
|
53
|
-
getState(appState) {
|
|
54
|
-
const config = appState.plots.find((p) => p.id === this.id);
|
|
55
|
-
if (!config) {
|
|
56
|
-
throw `No plot with id='${this.id}' found`;
|
|
57
|
-
}
|
|
58
|
-
return {
|
|
59
|
-
config
|
|
60
|
-
};
|
|
61
|
-
}
|
|
62
|
-
async main() {
|
|
63
|
-
const body = this.getParam();
|
|
64
|
-
const data = await dofetch3("mds3", { body });
|
|
65
|
-
plotHeatmap_R(data, this);
|
|
66
|
-
}
|
|
67
|
-
getParam() {
|
|
68
|
-
console.log(this.state.config.genes);
|
|
69
|
-
const body = {
|
|
70
|
-
genome: this.app.opts.state.vocab.genome,
|
|
71
|
-
dslabel: this.app.opts.state.vocab.dslabel,
|
|
72
|
-
geneExpression: 1,
|
|
73
|
-
genes: this.state.config.genes,
|
|
74
|
-
clusterMethod: this.state.config.clusterMethod
|
|
75
|
-
};
|
|
76
|
-
return body;
|
|
77
|
-
}
|
|
78
|
-
makeControls() {
|
|
79
|
-
const s = this.dom.controlsDiv.append("select");
|
|
80
|
-
for (const n of clusterMethodLst) s.append("option").text(n);
|
|
81
|
-
this.dom.clusterMethodSelect = s;
|
|
82
|
-
s.on("change", () => {
|
|
83
|
-
this.app.dispatch({
|
|
84
|
-
type: "plot_edit",
|
|
85
|
-
id: this.id,
|
|
86
|
-
config: { clusterMethod: clusterMethodLst[s.property("selectedIndex")] }
|
|
87
|
-
});
|
|
88
|
-
});
|
|
89
|
-
}
|
|
90
|
-
};
|
|
91
|
-
async function getPlotConfig(opts, app) {
|
|
92
|
-
try {
|
|
93
|
-
const config = structuredClone(defaultConfig);
|
|
94
|
-
return copyMerge(config, opts);
|
|
95
|
-
} catch (e) {
|
|
96
|
-
throw `${e} [geneExpression getPlotConfig()]`;
|
|
97
|
-
}
|
|
98
|
-
}
|
|
99
|
-
var geneExpressionInit = getCompInit(GeneExpression);
|
|
100
|
-
var componentInit = geneExpressionInit;
|
|
101
|
-
function makeChartBtnMenu(holder, chartsInstance) {
|
|
102
|
-
holder.append("div").attr("class", "sja_menuoption sja_sharp_border").text("Clustering analysis").on("click", () => {
|
|
103
|
-
chartsInstance.dom.tip.hide();
|
|
104
|
-
chartsInstance.prepPlot({
|
|
105
|
-
config: {
|
|
106
|
-
chartType: "geneExpression"
|
|
107
|
-
}
|
|
108
|
-
});
|
|
109
|
-
});
|
|
110
|
-
}
|
|
111
|
-
function plotHeatmap_R(data, self) {
|
|
112
|
-
self.dom.clusterMethodSelect.property("selectedIndex", clusterMethodLst.indexOf(self.state.config.clusterMethod));
|
|
113
|
-
self.dom.distanceMethodSelect.property("selectedIndex", distanceMethodLst.indexOf(self.state.config.distanceMethod));
|
|
114
|
-
const obj = data.clustering;
|
|
115
|
-
console.log(obj);
|
|
116
|
-
obj.d = {
|
|
117
|
-
minColor: "#0c306b",
|
|
118
|
-
maxColor: "#ffcc00",
|
|
119
|
-
xDendrogramHeight: 150,
|
|
120
|
-
yDendrogramHeight: 150
|
|
121
|
-
};
|
|
122
|
-
obj.d.colorScale = rgb_default(obj.d.minColor, obj.d.maxColor);
|
|
123
|
-
const ctx = self.dom.canvas.node().getContext("2d");
|
|
124
|
-
obj.d.rowHeight = getRowHeight(obj);
|
|
125
|
-
obj.d.colWidth = getColWidth(obj);
|
|
126
|
-
getLabHeight(ctx, obj);
|
|
127
|
-
self.dom.canvas.attr("width", obj.d.xDendrogramHeight + obj.d.xLabHeight + obj.d.colWidth * obj.matrix[0].length).attr("height", obj.d.yDendrogramHeight + obj.d.yLabHeight + obj.d.rowHeight * obj.matrix.length);
|
|
128
|
-
plotNames(obj, ctx);
|
|
129
|
-
drawHeatmap(obj, ctx);
|
|
130
|
-
plotDendrogram_R(ctx, obj);
|
|
131
|
-
plotHmColorScale(self, obj);
|
|
132
|
-
}
|
|
133
|
-
function plotDendrogram_R(ctx, obj) {
|
|
134
|
-
try {
|
|
135
|
-
obj.row_dendro.map(validateRline);
|
|
136
|
-
} catch (e) {
|
|
137
|
-
throw "row_dendro error: " + e;
|
|
138
|
-
}
|
|
139
|
-
try {
|
|
140
|
-
obj.col_dendro.map(validateRline);
|
|
141
|
-
} catch (e) {
|
|
142
|
-
throw "col_dendro error: " + e;
|
|
143
|
-
}
|
|
144
|
-
for (const r of obj.row_dendro) {
|
|
145
|
-
let t = r.x1;
|
|
146
|
-
r.x1 = r.y1;
|
|
147
|
-
r.y1 = t;
|
|
148
|
-
t = r.x2;
|
|
149
|
-
r.x2 = r.y2;
|
|
150
|
-
r.y2 = t;
|
|
151
|
-
}
|
|
152
|
-
{
|
|
153
|
-
let max = 0;
|
|
154
|
-
for (const r of obj.row_dendro) max = Math.max(max, r.x1, r.x2);
|
|
155
|
-
const sf = obj.d.xDendrogramHeight / max;
|
|
156
|
-
for (const r of obj.row_dendro) {
|
|
157
|
-
r.x1 = sf * (max - r.x1);
|
|
158
|
-
r.x2 = sf * (max - r.x2);
|
|
159
|
-
r.y1 *= obj.d.rowHeight;
|
|
160
|
-
r.y2 *= obj.d.rowHeight;
|
|
161
|
-
}
|
|
162
|
-
}
|
|
163
|
-
{
|
|
164
|
-
let max = 0;
|
|
165
|
-
for (const r of obj.col_dendro) max = Math.max(max, r.y1, r.y2);
|
|
166
|
-
const sf = obj.d.yDendrogramHeight / max;
|
|
167
|
-
for (const r of obj.col_dendro) {
|
|
168
|
-
r.y1 = sf * (max - r.y1);
|
|
169
|
-
r.y2 = sf * (max - r.y2);
|
|
170
|
-
r.x1 *= obj.d.colWidth;
|
|
171
|
-
r.x2 *= obj.d.colWidth;
|
|
172
|
-
}
|
|
173
|
-
}
|
|
174
|
-
ctx.strokeStyle = "black";
|
|
175
|
-
let F = obj.d.yDendrogramHeight + obj.d.yLabHeight;
|
|
176
|
-
for (const r of obj.row_dendro) {
|
|
177
|
-
ctx.beginPath();
|
|
178
|
-
const x1 = Math.min(r.x1, r.x2), x2 = Math.max(r.x1, r.x2), y1 = Math.min(r.y1, r.y2), y2 = Math.max(r.y1, r.y2);
|
|
179
|
-
ctx.moveTo(x1, y1 + F);
|
|
180
|
-
ctx.lineTo(x1, y2 + F);
|
|
181
|
-
if (r.x1 > r.x2 && r.y1 > r.y2 || r.x1 < r.x2 && r.y1 < r.y2) {
|
|
182
|
-
ctx.lineTo(x2, y2 + F);
|
|
183
|
-
} else {
|
|
184
|
-
ctx.moveTo(x1, y1 + F);
|
|
185
|
-
ctx.lineTo(x2, y1 + F);
|
|
186
|
-
}
|
|
187
|
-
ctx.stroke();
|
|
188
|
-
ctx.closePath();
|
|
189
|
-
}
|
|
190
|
-
F = obj.d.xDendrogramHeight + obj.d.xLabHeight;
|
|
191
|
-
for (const r of obj.col_dendro) {
|
|
192
|
-
ctx.beginPath();
|
|
193
|
-
const x1 = Math.min(r.x1, r.x2), x2 = Math.max(r.x1, r.x2), y1 = Math.min(r.y1, r.y2), y2 = Math.max(r.y1, r.y2);
|
|
194
|
-
ctx.moveTo(F + x1, y1);
|
|
195
|
-
ctx.lineTo(F + x2, y1);
|
|
196
|
-
if (r.x1 > r.x2 && r.y1 > r.y2 || r.x1 < r.x2 && r.y1 < r.y2) {
|
|
197
|
-
ctx.lineTo(F + x2, y2);
|
|
198
|
-
} else {
|
|
199
|
-
ctx.moveTo(F + x1, y1);
|
|
200
|
-
ctx.lineTo(F + x1, y2);
|
|
201
|
-
}
|
|
202
|
-
ctx.stroke();
|
|
203
|
-
ctx.closePath();
|
|
204
|
-
}
|
|
205
|
-
}
|
|
206
|
-
function validateRline(r) {
|
|
207
|
-
if (r.r1 < 0) throw `r.r1<0 ${r.r1}`;
|
|
208
|
-
if (r.r2 < 0) throw `r.r2<0 ${r.r2}`;
|
|
209
|
-
if (r.x1 < 1) throw `r.x1<1 ${r.x1}`;
|
|
210
|
-
if (r.x2 < 1) throw `r.x2<1 ${r.x2}`;
|
|
211
|
-
r.x1 -= 0.5;
|
|
212
|
-
r.x2 -= 0.5;
|
|
213
|
-
if (r.y1 < 0) throw `r.y1<0 ${r.y1}`;
|
|
214
|
-
if (r.y2 < 0) throw `r.y2<0 ${r.y2}`;
|
|
215
|
-
}
|
|
216
|
-
function plotNames(obj, ctx) {
|
|
217
|
-
if (obj.d.xLabHeight) {
|
|
218
|
-
ctx.font = obj.d.rowHeight + "px Arial";
|
|
219
|
-
ctx.textAlign = "end";
|
|
220
|
-
ctx.fillStyle = "black";
|
|
221
|
-
for (const [rowIdx, geneIdx] of obj.row_names_index.entries()) {
|
|
222
|
-
ctx.fillText(
|
|
223
|
-
obj.geneNameLst[geneIdx - 1],
|
|
224
|
-
obj.d.xDendrogramHeight + obj.d.xLabHeight,
|
|
225
|
-
obj.d.yDendrogramHeight + obj.d.yLabHeight + obj.d.rowHeight * (rowIdx + 1)
|
|
226
|
-
);
|
|
227
|
-
}
|
|
228
|
-
}
|
|
229
|
-
}
|
|
230
|
-
function drawHeatmap(obj, ctx) {
|
|
231
|
-
for (let i = 0; i < obj.row_names_index.length; i++) {
|
|
232
|
-
const sampleValues = obj.matrix[obj.row_names_index[i] - 1];
|
|
233
|
-
const [min, max] = getMinMax(sampleValues);
|
|
234
|
-
for (let j = 0; j < obj.col_names_index.length; j++) {
|
|
235
|
-
const v = sampleValues[obj.col_names_index[j] - 1];
|
|
236
|
-
ctx.fillStyle = obj.d.colorScale((v - min) / (max - min));
|
|
237
|
-
ctx.fillRect(
|
|
238
|
-
obj.d.xDendrogramHeight + obj.d.xLabHeight + obj.d.colWidth * j,
|
|
239
|
-
obj.d.yDendrogramHeight + obj.d.yLabHeight + obj.d.rowHeight * i,
|
|
240
|
-
obj.d.colWidth,
|
|
241
|
-
obj.d.rowHeight
|
|
242
|
-
);
|
|
243
|
-
}
|
|
244
|
-
}
|
|
245
|
-
}
|
|
246
|
-
function getRowHeight(obj) {
|
|
247
|
-
const h = 500 / obj.matrix.length;
|
|
248
|
-
if (h > 20) return 20;
|
|
249
|
-
if (h < 10) return 10;
|
|
250
|
-
return Math.ceil(h);
|
|
251
|
-
}
|
|
252
|
-
function getColWidth(obj) {
|
|
253
|
-
const w = 2e3 / obj.matrix[0].length;
|
|
254
|
-
if (w > 10) return 10;
|
|
255
|
-
return Math.ceil(w);
|
|
256
|
-
}
|
|
257
|
-
function getLabHeight(ctx, obj) {
|
|
258
|
-
if (obj.geneNameLst && obj.d.rowHeight >= 7) {
|
|
259
|
-
ctx.font = obj.d.rowHeight + "px Arial";
|
|
260
|
-
let max = 0;
|
|
261
|
-
for (const n of obj.geneNameLst) {
|
|
262
|
-
max = Math.max(max, ctx.measureText(n).width);
|
|
263
|
-
}
|
|
264
|
-
obj.d.xLabHeight = max;
|
|
265
|
-
} else {
|
|
266
|
-
obj.d.xLabHeight = 0;
|
|
267
|
-
}
|
|
268
|
-
if (obj.sampleNameLst && obj.d.colWidth >= 7) {
|
|
269
|
-
ctx.font = obj.d.colWidth + "px Arial";
|
|
270
|
-
let max = 0;
|
|
271
|
-
for (const n of obj.sampleNameLst) {
|
|
272
|
-
max = Math.max(max, ctx.measureText(n).width);
|
|
273
|
-
}
|
|
274
|
-
obj.d.yLabHeight = max;
|
|
275
|
-
} else {
|
|
276
|
-
obj.d.yLabHeight = 0;
|
|
277
|
-
}
|
|
278
|
-
}
|
|
279
|
-
function getMinMax(row) {
|
|
280
|
-
let min = null, max;
|
|
281
|
-
for (const v of row) {
|
|
282
|
-
if (min == null) {
|
|
283
|
-
min = v;
|
|
284
|
-
max = v;
|
|
285
|
-
} else {
|
|
286
|
-
min = Math.min(min, v);
|
|
287
|
-
max = Math.max(max, v);
|
|
288
|
-
}
|
|
289
|
-
}
|
|
290
|
-
return [min, max];
|
|
291
|
-
}
|
|
292
|
-
function plotHmColorScale(self, obj) {
|
|
293
|
-
self.dom.colorScaleDiv.selectAll("*").remove();
|
|
294
|
-
const width = 100, height = 20;
|
|
295
|
-
self.dom.colorScaleDiv.append("span").text("Min");
|
|
296
|
-
const svg = self.dom.colorScaleDiv.append("svg");
|
|
297
|
-
self.dom.colorScaleDiv.append("span").text("Max");
|
|
298
|
-
const grad = svg.append("defs").append("linearGradient").attr("id", "grad");
|
|
299
|
-
grad.append("stop").attr("offset", "0%").attr("stop-color", obj.d.minColor);
|
|
300
|
-
grad.append("stop").attr("offset", "100%").attr("stop-color", obj.d.maxColor);
|
|
301
|
-
svg.append("rect").attr("width", width).attr("height", height).attr("fill", "url(#grad)");
|
|
302
|
-
svg.attr("width", width).attr("height", height);
|
|
303
|
-
}
|
|
304
|
-
export {
|
|
305
|
-
componentInit,
|
|
306
|
-
geneExpressionInit,
|
|
307
|
-
getPlotConfig,
|
|
308
|
-
makeChartBtnMenu
|
|
309
|
-
};
|
|
310
|
-
//# sourceMappingURL=geneExpression-FXQ4L2J2.js.map
|
|
@@ -1,33 +0,0 @@
|
|
|
1
|
-
import {
|
|
2
|
-
SearchHandler
|
|
3
|
-
} from "./chunk-DHNET3P4.js";
|
|
4
|
-
import "./chunk-Q5SK3U2T.js";
|
|
5
|
-
import "./chunk-HJ6L54YS.js";
|
|
6
|
-
import "./chunk-KV4W2ACA.js";
|
|
7
|
-
import "./chunk-54KC7DAB.js";
|
|
8
|
-
import "./chunk-N7DVQTPC.js";
|
|
9
|
-
import "./chunk-ELJX3QIQ.js";
|
|
10
|
-
import "./chunk-EEB5VE2A.js";
|
|
11
|
-
import "./chunk-6RRZRISL.js";
|
|
12
|
-
import "./chunk-2KM4PRQM.js";
|
|
13
|
-
import "./chunk-RPDVFM7E.js";
|
|
14
|
-
import "./chunk-M4XXKTH2.js";
|
|
15
|
-
import "./chunk-5ILEFNXJ.js";
|
|
16
|
-
import "./chunk-IZUYLFOX.js";
|
|
17
|
-
import "./chunk-WINIL2KN.js";
|
|
18
|
-
import "./chunk-PF4DSFDR.js";
|
|
19
|
-
import "./chunk-7X6NF7NI.js";
|
|
20
|
-
import "./chunk-W5J3LTYS.js";
|
|
21
|
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import "./chunk-Z2ZITHT4.js";
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{
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"sourcesContent": ["import tape from 'tape'\nimport { SearchHandler } from '../geneExpression.ts'\nimport { TermTypes } from '#types'\n\n/**************\n test sections\n***************/\n\ntape('\\n', function (test) {\n\ttest.comment('-***- termdb/handlers/geneExpression -***-')\n\ttest.end()\n})\n\ntape('selectGene() should throw when no gene is selected', async test => {\n\tconst handler = new SearchHandler()\n\thandler.app = { vocabApi: { termdbConfig: { queries: { geneExpression: {} } } } } as any\n\thandler.callback = () => {}\n\n\ttry {\n\t\tawait handler.selectGene(undefined)\n\t\ttest.fail('Should throw when no gene is selected')\n\t} catch (e) {\n\t\ttest.match(String(e), /No gene selected/, 'Should throw expected message when gene is missing')\n\t}\n\n\ttest.end()\n})\n\ntape('selectGene() should call callback with configured unit from termdbConfig', async test => {\n\tconst handler = new SearchHandler()\n\tlet selected: any\n\n\thandler.callback = t => {\n\t\tselected = t\n\t}\n\thandler.app = {\n\t\tvocabApi: {\n\t\t\ttermdbConfig: {\n\t\t\t\tqueries: {\n\t\t\t\t\tgeneExpression: { unit: 'log2 TPM' }\n\t\t\t\t}\n\t\t\t}\n\t\t}\n\t} as any\n\n\tawait handler.selectGene({ geneSymbol: 'TP53', sampleType: 'tumor' })\n\ttest.equal(selected?.q?.sampleType, 'tumor', 'Should pass selected sampleType in q payload')\n\ttest.equal(selected?.term.gene, 'TP53', 'Should pass selected gene')\n\ttest.equal(selected?.term.name, 'TP53 log2 TPM', 'Should include configured unit in term name')\n\ttest.equal(selected?.term.type, TermTypes.GENE_EXPRESSION, 'Should set type to geneExpression')\n\n\ttest.end()\n})\n\ntape('selectGene() should use default unit when not configured', async test => {\n\tconst handler = new SearchHandler()\n\tlet selected: any\n\n\thandler.callback = t => {\n\t\tselected = t\n\t}\n\thandler.app = {\n\t\tvocabApi: {\n\t\t\ttermdbConfig: {\n\t\t\t\tqueries: {}\n\t\t\t}\n\t\t}\n\t} as any\n\n\tawait handler.selectGene({ geneSymbol: 'BRCA1' })\n\ttest.equal(selected?.q?.sampleType, undefined, 'Should include sampleType key with undefined value when not provided')\n\ttest.equal(selected?.term.gene, 'BRCA1', 'Should pass selected gene')\n\ttest.equal(selected?.term.name, 'BRCA1 Gene Expression', 'Should use default unit when config unit is not provided')\n\ttest.equal(selected?.term.type, TermTypes.GENE_EXPRESSION, 'Should set type to geneExpression')\n\n\ttest.end()\n})\n"],
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