@sjcrh/proteinpaint-client 2.200.0 → 2.201.0

package/dist/chunk-YUURGVV3.js

@@ -0,0 +1,275 @@
+import {
+  SINGLECELL_CELLTYPE,
+  SINGLECELL_GENE_EXPRESSION
+} from "./chunk-GEQUQ3GG.js";
+
+// test/testdata/data.ts
+function getSamplelstTw() {
+  const values = [
+    {
+      sampleId: 42,
+      sample: "2660"
+    },
+    {
+      sampleId: 44,
+      sample: "2688"
+    },
+    {
+      sampleId: 45,
+      sample: "2702"
+    },
+    {
+      sampleId: 46,
+      sample: "2716"
+    },
+    {
+      sampleId: 59,
+      sample: "2898"
+    },
+    {
+      sampleId: 60,
+      sample: "2912"
+    },
+    {
+      sampleId: 67,
+      sample: "3010"
+    },
+    {
+      sampleId: 68,
+      sample: "3024"
+    },
+    {
+      sampleId: 69,
+      sample: "3038"
+    },
+    {
+      sampleId: 70,
+      sample: "3052"
+    },
+    {
+      sampleId: 73,
+      sample: "3094"
+    },
+    {
+      sampleId: 79,
+      sample: "3178"
+    },
+    {
+      sampleId: 80,
+      sample: "3192"
+    }
+  ];
+  return {
+    term: {
+      name: "termdbtest samplelst",
+      type: "samplelst",
+      values: {
+        "Group 1": {
+          key: "Group 1",
+          label: "Group 1",
+          list: values
+        },
+        "Not in Group 1": {
+          key: "Not in Group 1",
+          label: "Not in Group 1",
+          list: values
+        }
+      }
+    },
+    q: {
+      mode: "discrete",
+      groups: [
+        {
+          name: "Group 1",
+          in: true,
+          values
+        },
+        {
+          name: "Not in Group 1",
+          in: false,
+          values
+        }
+      ],
+      isAtomic: true
+    }
+  };
+}
+function getCategoryGroupsetting() {
+  return {
+    id: "diaggrp",
+    q: {
+      type: "custom-groupset",
+      customset: {
+        name: "A versus B",
+        groups: [
+          {
+            name: "Test A",
+            type: "values",
+            values: [{ key: "Acute lymphoblastic leukemia" }, { key: "Wilms tumor" }]
+          },
+          {
+            name: "Test B",
+            type: "values",
+            values: [
+              { key: "Central nervous system (CNS)" },
+              { key: "Acute myeloid leukemia" },
+              { key: "Non-Hodgkin lymphoma" }
+            ]
+          }
+        ]
+      }
+    }
+  };
+}
+function getGenesetMutTw() {
+  return {
+    term: {
+      genes: [
+        { kind: "gene", gene: "TP53", type: "geneVariant" },
+        { kind: "gene", gene: "KRAS", type: "geneVariant" },
+        { kind: "gene", gene: "AKT1", type: "geneVariant" },
+        { kind: "gene", gene: "BCR", type: "geneVariant" }
+      ],
+      type: "geneVariant"
+    },
+    q: { type: "predefined-groupset" }
+  };
+}
+function getGeneVariantTw(position = false) {
+  return {
+    term: {
+      genes: [
+        position ? { kind: "coord", chr: "chr12", start: 25205246, stop: 25250936, name: "KRASregion", type: "geneVariant" } : { kind: "gene", gene: "TP53", type: "geneVariant" }
+      ],
+      type: "geneVariant"
+    },
+    q: { type: "predefined-groupset", predefined_groupset_idx: 0, hiddenValues: {} }
+  };
+}
+function getSsgseaTw(isBin = false) {
+  return {
+    term: { id: "HALLMARK_ADIPOGENESIS", type: "ssGSEA", name: "HALLMARK_ADIPOGENESIS" },
+    q: isBin ? {
+      type: "regular-bin",
+      startinclusive: true,
+      bin_size: 0.2,
+      first_bin: { stop: -0.4 },
+      last_bin: { start: 0.8 },
+      mode: "discrete"
+    } : { mode: "continuous" }
+  };
+}
+function getScgeneexpTw(gene = "KRAS") {
+  return {
+    term: {
+      type: SINGLECELL_GENE_EXPRESSION,
+      id: gene,
+      gene,
+      name: gene,
+      sample: {
+        sID: "1_patient"
+      }
+    },
+    q: {
+      mode: "continuous"
+    }
+  };
+}
+function getScctTw() {
+  return {
+    term: {
+      type: SINGLECELL_CELLTYPE,
+      id: "CellType",
+      name: "Cell Type",
+      sample: {
+        sID: "1_patient"
+      },
+      plot: "UMAP",
+      colorBy: "CellType",
+      values: {
+        T_NK: {
+          key: "T_NK",
+          value: "T_NK"
+        },
+        Blast: {
+          key: "Blast",
+          value: "Blast"
+        },
+        Monocyte: {
+          key: "Monocyte",
+          value: "Monocyte"
+        }
+      },
+      groupsetting: {
+        disabled: false
+      }
+    }
+  };
+}
+function getCategoricalTermcollectionTw() {
+  return {
+    type: "TermCollectionTWQual",
+    term: { type: "termCollection", name: "Assay Availability" }
+  };
+}
+function getAgeCollectionFractionTw() {
+  return {
+    type: "TermCollectionTWFraction",
+    term: {
+      type: "termCollection",
+      termIds: ["agedx", "a_death", "a_ndi", "agelastvisit"],
+      name: "Fake Collection 1",
+      // NOTE this name must match with the termCollection entry in termdbtest
+      memberType: "numeric"
+    },
+    q: {
+      mode: "discrete",
+      numerators: ["a_death"],
+      denominators: ["agedx", "a_death"],
+      type: "custom-bin",
+      lst: [
+        { startunbounded: true, stop: 0.8, label: "<0.8" },
+        { stopunbounded: true, start: 0.8, label: ">0.8" }
+      ]
+    }
+  };
+}
+function getIsoformExpCollectionFractionTw() {
+  return {
+    type: "TermCollectionTWFraction",
+    term: {
+      type: "termCollection",
+      isCustom: true,
+      memberType: "numeric",
+      name: "KRAS Isoforms (TPM)",
+      termlst: [
+        { id: "ENST00000256078", name: "ENST00000256078", type: "isoformExpression", isoform: "ENST00000256078" },
+        { id: "ENST00000311936", name: "ENST00000311936", type: "isoformExpression", isoform: "ENST00000311936" }
+      ]
+    },
+    q: {
+      mode: "discrete",
+      type: "custom-bin",
+      lst: [
+        { startunbounded: true, stop: 0.1, startinclusive: false, stopinclusive: true, label: "low0.1" },
+        { start: 0.1, startinclusive: false, stopinclusive: false, stopunbounded: true, label: "high0.1" }
+      ],
+      denominators: ["ENST00000256078", "ENST00000311936"],
+      numerators: ["ENST00000256078"]
+    }
+  };
+}
+
+export {
+  getSamplelstTw,
+  getCategoryGroupsetting,
+  getGenesetMutTw,
+  getGeneVariantTw,
+  getSsgseaTw,
+  getScgeneexpTw,
+  getScctTw,
+  getCategoricalTermcollectionTw,
+  getAgeCollectionFractionTw,
+  getIsoformExpCollectionFractionTw
+};
+//# sourceMappingURL=chunk-YUURGVV3.js.map

package/dist/chunk-Z7VK2AMA.js

@@ -0,0 +1,292 @@
+import {
+  getSortOptions
+} from "./chunk-UO7MD3XA.js";
+import {
+  defaultUiLabels,
+  fillTermWrapper
+} from "./chunk-K6OVOHIZ.js";
+import {
+  isDictionaryType
+} from "./chunk-X6VTVZY7.js";
+import {
+  copyMerge
+} from "./chunk-M3J4MINX.js";
+import {
+  CNVClasses,
+  dtcnv,
+  mclass,
+  mutationClasses,
+  proteinChangingMutations,
+  synonymousMutations,
+  truncatingMutations
+} from "./chunk-GEQUQ3GG.js";
+
+// plots/matrix/matrix.config.js
+async function getPlotConfig(opts = {}, app) {
+  const controlLabels = structuredClone(defaultUiLabels);
+  const devicePixelRatio = opts.devicePixelRatio || window.devicePixelRatio;
+  const config = {
+    // data configuration
+    termgroups: [],
+    samplegroups: [],
+    divideBy: null,
+    legendValueFilter: {
+      isAtomic: true,
+      type: "tvslst",
+      in: true,
+      join: "and",
+      lst: []
+    },
+    legendGrpFilter: {
+      isAtomic: true,
+      type: "tvslst",
+      in: true,
+      join: "and",
+      lst: []
+    },
+    filter: {
+      isAtomic: true,
+      type: "tvslst",
+      in: true,
+      join: "and",
+      lst: []
+    },
+    // cnvCutoffs: {},
+    // rendering options
+    settings: {
+      matrix: {
+        svgCanvasSwitch: 1e3,
+        // the number of samples to trigger switching between svg and canvas
+        useMinPixelWidth: true,
+        // canvas may be hazy if false, but more accurately reflects column density
+        cellEncoding: "",
+        // can be "oncoprint" | "stacked" | "single"
+        margin: {
+          top: 10,
+          right: 5,
+          bottom: 20,
+          left: 50
+        },
+        // set any dataset-defined sample limits and sort priority, otherwise undefined
+        // put in settings, so that later may be overridden by a user
+        maxGenes: opts.settings?.maxGenes || 50,
+        maxSample: opts.settings?.maxSample || 1e3,
+        sampleNameFilter: "",
+        sortSamplesBy: "a",
+        sortPriority: void 0,
+        // will be filled-in
+        // sortByMutation: 'consequence', computed
+        // sortByCNV: true, computed
+        //sortOptions: getSortOptions(app.vocabApi.termdbConfig, controlLabels),
+        sortSampleGrpsBy: "name",
+        // 'hits' | 'name' | 'sampleCount'
+        sortSamplesTieBreakers: [{
+          $id: "sample",
+          sortSamples: {}
+          /*split: {char: '', index: 0}*/
+        }],
+        sortTermsBy: "sampleCount",
+        // or 'as listed'
+        // do not show number of samples at hiercluster gene row labels
+        samplecount4gene: opts.chartType == "hierCluster" ? "" : "abs",
+        //true, // 'abs' (default, previously true), 'pct', ''  (previously false)
+        geneVariantCountSamplesSkipMclass: [],
+        cellbg: "#ececec",
+        showGrid: "",
+        // false | 'pattern' | 'rect'
+        // whether to show these controls buttons
+        addMutationCNVButtons: false,
+        truncatingMutations,
+        proteinChangingMutations,
+        synonymousMutations,
+        mutationClasses,
+        CNVClasses,
+        gridStroke: "#fff",
+        outlineStroke: "#ccc",
+        beamStroke: "#f00",
+        colw: 0,
+        colwMin: 0.1 / devicePixelRatio,
+        colwMax: 16,
+        colspace: 1,
+        colgspace: 8,
+        colglabelpos: true,
+        collabelpos: "bottom",
+        collabelvisible: true,
+        collabelgap: 5,
+        collabelpad: 1,
+        collabelmaxchars: 32,
+        rowh: 18,
+        //use 0 to auto-compute row height, previous default=18,
+        rowhMin: 1,
+        rowhMax: 20,
+        rowspace: 1,
+        rowgspace: 8,
+        rowlabelpos: "left",
+        // | 'right'
+        rowlabelgap: 5,
+        rowlabelvisible: true,
+        rowlabelpad: 1,
+        rowlabelmaxchars: 32,
+        legendGrpLabelMaxChars: 26,
+        grpLabelFontSize: 12,
+        minLabelFontSize: 6,
+        maxLabelFontSize: 14,
+        transpose: false,
+        // 'auto' shows column labels only when columns are wide enough (colw >= minLabelFontSize);
+        sampleLabelsToggle: "auto",
+        // 'auto' | 'hide'
+        sampleLabelOffset: 120,
+        sampleGrpLabelOffset: 120,
+        sampleGrpLabelMaxChars: 32,
+        termLabelOffset: 80,
+        termGrpLabelOffset: 80,
+        termGrpLabelMaxChars: 32,
+        duration: 0,
+        zoomLevel: 1,
+        zoomCenterPct: 0,
+        zoomIndex: 0,
+        zoomGrpIndex: 0,
+        zoomMin: 0.5,
+        zoomIncrement: 0.1,
+        zoomStep: 1,
+        // renderedWMax should not be exposed as a user-input
+        // 60000 pixels is based on laptop and external monitor tests,
+        // when a canvas dataURL image in a zoomed-in matrix svg stops rendering
+        imgWMax: 6e4 / devicePixelRatio,
+        scrollHeight: 12,
+        controlLabels,
+        cnvUnit: "log2ratio",
+        ignoreCnvValues: false,
+        //will ignore numeric CNV values if true
+        barh: 32,
+        // default bar height for continuous terms,
+        // possible string entries:
+        // - "genesetEdit", for gene-centric embedders only like GDC OncoMatrix
+        // - may add other optional hints later
+        showHints: [],
+        genesetEditUiVersion: "",
+        // '' | 'withTabs'
+        // settings for a specific tw
+        twSpecificSettings: {},
+        oncoPrintSNVindelCellBorder: false,
+        // whether to show white cell border for SNVindel in oncoPrint mode
+        cnvValues: {
+          //Properties match the args for the ColorScales
+          //numericInput arg
+          cutoffMode: "percentile",
+          defaultPercentile: 99,
+          min: null,
+          max: null,
+          percentile: 99
+        }
+      }
+    }
+  };
+  const s = config.settings;
+  const fontsize = Math.max(s.matrix.rowh + s.matrix.rowspace - 3 * s.matrix.rowlabelpad, 12);
+  s.legend = {
+    ontop: false,
+    lineh: 25,
+    padx: 5,
+    padleft: 0,
+    //150,
+    padright: 20,
+    padbtm: 30,
+    fontsize,
+    iconh: fontsize - 2,
+    iconw: fontsize - 2,
+    hangleft: 1,
+    linesep: false
+  };
+  const overrides = app.vocabApi.termdbConfig.matrix || {};
+  copyMerge(config.settings.matrix, overrides.settings);
+  if (overrides.legendGrpFilter) config.legendGrpFilter = overrides.legendGrpFilter;
+  if (overrides.legendValueFilter) config.legendValueFilter = overrides.legendValueFilter;
+  if (overrides.filter) config.filter = overrides.filter;
+  if (opts.name) {
+    const data = await app.vocabApi.getMatrixByName(opts.name);
+    if (!data) throw "error from getMatrixByName()";
+    if (data.error) throw data.error;
+    copyMerge(config, data);
+  }
+  const os = opts?.settings?.matrix;
+  if (os) {
+    if ((os.sortSamplesBy == "custom" || os.sortSamplesBy == "asListed") && os.sortOptions?.custom.label == "against alteration type") {
+      os.sortSamplesBy = "a";
+    }
+    if (os.sortOptions) {
+      delete os.sortOptions.custom;
+      delete os.sortOptions.asListed;
+    }
+  }
+  copyMerge(config, opts);
+  const m = config.settings.matrix;
+  m.sortOptions = getSortOptions(app.vocabApi.termdbConfig, controlLabels, m);
+  m.duration = 0;
+  m.colw = 0;
+  if (m.sortSamplesBy != "asListed" && !m.sortOptions?.[m.sortSamplesBy]) m.sortSamplesBy = "a";
+  else if (["selectedTerms", "class", "dt", "hits"].includes(m.sortSamplesBy)) m.sortSamplesBy = "a";
+  if (m.samplecount4gene === true || m.samplecount4gene === 1) m.samplecount4gene = "abs";
+  if (window.location.hostname == "localhost") {
+    if (window.location.hash == "#canvas") m.svgCanvasSwitch = 0;
+  }
+  for (const grp of config.termgroups) {
+    const promises = [];
+    for (const tw of grp.lst) {
+      if (!tw.term?.type || isDictionaryType(tw.term.type)) {
+        if (!tw.id && tw.term.type != "samplelst" && tw.term.type != "termCollection") {
+          if (!tw.term.id) throw `missing tw.id and tw.term.id`;
+          tw.id = tw.term.id;
+        }
+        if (tw.term?.type != "samplelst" && tw.term?.type != "termCollection") delete tw.term;
+      }
+      promises.push(fillTermWrapper(tw, app.vocabApi));
+    }
+    grp.lst = await Promise.all(promises);
+  }
+  if (config.divideBy) config.divideBy = await fillTermWrapper(config.divideBy, app.vocabApi);
+  return config;
+}
+function setComputedConfig(config) {
+  const s = config.settings.matrix;
+  const allClasses = [...s.mutationClasses, ...s.CNVClasses];
+  s.filterByClass = { isAtomic: true };
+  for (const f of config.legendGrpFilter.lst) {
+    if (!f.dt) continue;
+    allClasses.filter((m) => f.dt.includes(mclass[m].dt)).forEach((key2) => {
+      s.filterByClass[key2] = "value";
+    });
+  }
+  for (const f of config.legendValueFilter.lst) {
+    if (!f.legendGrpName || f.tvs?.term?.type !== "geneVariant") continue;
+    if (f.tvs.values?.[0].mclasslst)
+      f.tvs.values[0].mclasslst.forEach((key2) => {
+        s.filterByClass[key2] = f.legendFilterType?.endsWith("_hard") ? "case" : "value";
+      });
+    else if (f.tvs.values)
+      f.tvs.values.forEach((v) => {
+        s.filterByClass[key] = "value";
+      });
+    else throw `unhandled tvs from legendValueFilter`;
+  }
+  s.hiddenVariants = Object.keys(s.filterByClass).filter((c) => c !== "isAtomic");
+  const hiddenCNVs = new Set(s.hiddenVariants.filter((key2) => mclass[key2]?.dt === dtcnv));
+  s.hiddenCNVs = [...hiddenCNVs];
+  s.showMatrixCNV = !hiddenCNVs.size ? "all" : hiddenCNVs.size == s.CNVClasses.length ? "none" : "bySelection";
+  s.allMatrixCNVHidden = hiddenCNVs.size == s.CNVClasses.length;
+  const hiddenMutations = new Set(s.hiddenVariants.filter((key2) => s.mutationClasses.find((k) => k === key2)));
+  s.hiddenMutations = [...hiddenMutations];
+  const PCset = new Set(s.proteinChangingMutations);
+  const TMset = new Set(s.truncatingMutations);
+  s.showMatrixMutation = !hiddenMutations.size ? "all" : hiddenMutations.size == s.mutationClasses.length ? "none" : hiddenMutations.size === s.mutationClasses.length - PCset.size && [...hiddenMutations].every((m) => !PCset.has(m)) ? "onlyPC" : hiddenMutations.size === s.mutationClasses.length - TMset.size && [...hiddenMutations].every((m) => !TMset.has(m)) ? "onlyTruncating" : "bySelection";
+  s.allMatrixMutationHidden = hiddenMutations.size == s.mutationClasses.length;
+  const tiebreakers = s.sortOptions.a?.sortPriority.find((sp) => sp.types.length == 1 && sp.types[0] == "geneVariant")?.tiebreakers || [];
+  s.sortByMutation = tiebreakers.find((tb) => tb.filter?.values[0]?.dt === 1)?.isOrdered ? "consequence" : "presence";
+  s.sortByCNV = tiebreakers.find((tb) => tb.filter?.values[0]?.dt === 4)?.disabled !== true;
+}
+
+export {
+  getPlotConfig,
+  setComputedConfig
+};
+//# sourceMappingURL=chunk-Z7VK2AMA.js.map