@sjcrh/proteinpaint-client 2.187.0 → 2.188.0

package/dist/singlecell-MOSYT3RI.js

@@ -0,0 +1,1571 @@
+import {
+  BufferGeometry,
+  Color,
+  EventDispatcher,
+  FileLoader,
+  Float32BufferAttribute,
+  Int32BufferAttribute,
+  LinearSRGBColorSpace,
+  Loader,
+  MOUSE,
+  MathUtils,
+  NoToneMapping,
+  PerspectiveCamera,
+  Points,
+  PointsMaterial,
+  Quaternion,
+  Scene,
+  Vector2,
+  Vector3,
+  WebGLRenderer
+} from "./chunk-72PLI3GC.js";
+import {
+  legend_newrow
+} from "./chunk-VAUSRBL5.js";
+import {
+  schemeCategory20
+} from "./chunk-V2OJLJSK.js";
+import {
+  findgenemodel_bysymbol,
+  gene_searchbox
+} from "./chunk-ZEJB7CPC.js";
+import "./chunk-RQ2ZJ66W.js";
+import {
+  appear2 as appear,
+  disappear2 as disappear,
+  font,
+  newpane,
+  sayerror
+} from "./chunk-2XPDA6NL.js";
+import "./chunk-HJ6L54YS.js";
+import "./chunk-LSEFWW72.js";
+import "./chunk-GHWHLSUX.js";
+import {
+  Menu
+} from "./chunk-HYOEWQ5P.js";
+import "./chunk-HBW42TDT.js";
+import "./chunk-G6O3URDN.js";
+import "./chunk-FN5XPUPH.js";
+import "./chunk-KWM6B3NL.js";
+import "./chunk-UCLS2SVB.js";
+import "./chunk-AY4UBGLC.js";
+import "./chunk-2P6Z7JFC.js";
+import {
+  dofetch,
+  dofetch2
+} from "./chunk-MYWJQRTD.js";
+import "./chunk-MVTCBVSX.js";
+import "./chunk-B43MTEYB.js";
+import "./chunk-2T7VYQLY.js";
+import "./chunk-FDK4UJMN.js";
+import "./chunk-X7GDCYND.js";
+import "./chunk-SJC2C77V.js";
+import "./chunk-C3SYSMNE.js";
+import {
+  area_default,
+  line_default,
+  monotoneX,
+  plasma
+} from "./chunk-KSGA62R2.js";
+import {
+  axisBottom,
+  axisLeft,
+  axisTop
+} from "./chunk-LOZEKOES.js";
+import "./chunk-TOU7EVFQ.js";
+import {
+  band,
+  linear,
+  ordinal,
+  sequential
+} from "./chunk-OAWQ6LOO.js";
+import "./chunk-NMBIT4IK.js";
+import "./chunk-KYBIQBXE.js";
+import {
+  pointer_default
+} from "./chunk-I6Y4O3RR.js";
+import "./chunk-OMR2DT66.js";
+import "./chunk-DQC5FFGV.js";
+import "./chunk-HFNDKYVF.js";
+
+// ../node_modules/three/examples/jsm/loaders/PCDLoader.js
+var PCDLoader = class extends Loader {
+  constructor(manager) {
+    super(manager);
+    this.littleEndian = true;
+  }
+  load(url, onLoad, onProgress, onError) {
+    const scope = this;
+    const loader = new FileLoader(scope.manager);
+    loader.setPath(scope.path);
+    loader.setResponseType("arraybuffer");
+    loader.setRequestHeader(scope.requestHeader);
+    loader.setWithCredentials(scope.withCredentials);
+    loader.load(url, function(data) {
+      try {
+        onLoad(scope.parse(data));
+      } catch (e) {
+        if (onError) {
+          onError(e);
+        } else {
+          console.error(e);
+        }
+        scope.manager.itemError(url);
+      }
+    }, onProgress, onError);
+  }
+  parse(data) {
+    function decompressLZF(inData, outLength) {
+      const inLength = inData.length;
+      const outData = new Uint8Array(outLength);
+      let inPtr = 0;
+      let outPtr = 0;
+      let ctrl;
+      let len;
+      let ref;
+      do {
+        ctrl = inData[inPtr++];
+        if (ctrl < 1 << 5) {
+          ctrl++;
+          if (outPtr + ctrl > outLength) throw new Error("Output buffer is not large enough");
+          if (inPtr + ctrl > inLength) throw new Error("Invalid compressed data");
+          do {
+            outData[outPtr++] = inData[inPtr++];
+          } while (--ctrl);
+        } else {
+          len = ctrl >> 5;
+          ref = outPtr - ((ctrl & 31) << 8) - 1;
+          if (inPtr >= inLength) throw new Error("Invalid compressed data");
+          if (len === 7) {
+            len += inData[inPtr++];
+            if (inPtr >= inLength) throw new Error("Invalid compressed data");
+          }
+          ref -= inData[inPtr++];
+          if (outPtr + len + 2 > outLength) throw new Error("Output buffer is not large enough");
+          if (ref < 0) throw new Error("Invalid compressed data");
+          if (ref >= outPtr) throw new Error("Invalid compressed data");
+          do {
+            outData[outPtr++] = outData[ref++];
+          } while (--len + 2);
+        }
+      } while (inPtr < inLength);
+      return outData;
+    }
+    function parseHeader(data2) {
+      const PCDheader2 = {};
+      const result1 = data2.search(/[\r\n]DATA\s(\S*)\s/i);
+      const result2 = /[\r\n]DATA\s(\S*)\s/i.exec(data2.slice(result1 - 1));
+      PCDheader2.data = result2[1];
+      PCDheader2.headerLen = result2[0].length + result1;
+      PCDheader2.str = data2.slice(0, PCDheader2.headerLen);
+      PCDheader2.str = PCDheader2.str.replace(/#.*/gi, "");
+      PCDheader2.version = /VERSION (.*)/i.exec(PCDheader2.str);
+      PCDheader2.fields = /FIELDS (.*)/i.exec(PCDheader2.str);
+      PCDheader2.size = /SIZE (.*)/i.exec(PCDheader2.str);
+      PCDheader2.type = /TYPE (.*)/i.exec(PCDheader2.str);
+      PCDheader2.count = /COUNT (.*)/i.exec(PCDheader2.str);
+      PCDheader2.width = /WIDTH (.*)/i.exec(PCDheader2.str);
+      PCDheader2.height = /HEIGHT (.*)/i.exec(PCDheader2.str);
+      PCDheader2.viewpoint = /VIEWPOINT (.*)/i.exec(PCDheader2.str);
+      PCDheader2.points = /POINTS (.*)/i.exec(PCDheader2.str);
+      if (PCDheader2.version !== null)
+        PCDheader2.version = parseFloat(PCDheader2.version[1]);
+      PCDheader2.fields = PCDheader2.fields !== null ? PCDheader2.fields[1].split(" ") : [];
+      if (PCDheader2.type !== null)
+        PCDheader2.type = PCDheader2.type[1].split(" ");
+      if (PCDheader2.width !== null)
+        PCDheader2.width = parseInt(PCDheader2.width[1]);
+      if (PCDheader2.height !== null)
+        PCDheader2.height = parseInt(PCDheader2.height[1]);
+      if (PCDheader2.viewpoint !== null)
+        PCDheader2.viewpoint = PCDheader2.viewpoint[1];
+      if (PCDheader2.points !== null)
+        PCDheader2.points = parseInt(PCDheader2.points[1], 10);
+      if (PCDheader2.points === null)
+        PCDheader2.points = PCDheader2.width * PCDheader2.height;
+      if (PCDheader2.size !== null) {
+        PCDheader2.size = PCDheader2.size[1].split(" ").map(function(x) {
+          return parseInt(x, 10);
+        });
+      }
+      if (PCDheader2.count !== null) {
+        PCDheader2.count = PCDheader2.count[1].split(" ").map(function(x) {
+          return parseInt(x, 10);
+        });
+      } else {
+        PCDheader2.count = [];
+        for (let i = 0, l = PCDheader2.fields.length; i < l; i++) {
+          PCDheader2.count.push(1);
+        }
+      }
+      PCDheader2.offset = {};
+      let sizeSum = 0;
+      for (let i = 0, l = PCDheader2.fields.length; i < l; i++) {
+        if (PCDheader2.data === "ascii") {
+          PCDheader2.offset[PCDheader2.fields[i]] = i;
+        } else {
+          PCDheader2.offset[PCDheader2.fields[i]] = sizeSum;
+          sizeSum += PCDheader2.size[i] * PCDheader2.count[i];
+        }
+      }
+      PCDheader2.rowSize = sizeSum;
+      return PCDheader2;
+    }
+    const textData = new TextDecoder().decode(data);
+    const PCDheader = parseHeader(textData);
+    const position = [];
+    const normal = [];
+    const color = [];
+    const intensity = [];
+    const label = [];
+    if (PCDheader.data === "ascii") {
+      const offset = PCDheader.offset;
+      const pcdData = textData.slice(PCDheader.headerLen);
+      const lines = pcdData.split("\n");
+      for (let i = 0, l = lines.length; i < l; i++) {
+        if (lines[i] === "") continue;
+        const line = lines[i].split(" ");
+        if (offset.x !== void 0) {
+          position.push(parseFloat(line[offset.x]));
+          position.push(parseFloat(line[offset.y]));
+          position.push(parseFloat(line[offset.z]));
+        }
+        if (offset.rgb !== void 0) {
+          const rgb_field_index = PCDheader.fields.findIndex((field) => field === "rgb");
+          const rgb_type = PCDheader.type[rgb_field_index];
+          const float = parseFloat(line[offset.rgb]);
+          let rgb = float;
+          if (rgb_type === "F") {
+            const farr = new Float32Array(1);
+            farr[0] = float;
+            rgb = new Int32Array(farr.buffer)[0];
+          }
+          const r = rgb >> 16 & 255;
+          const g = rgb >> 8 & 255;
+          const b = rgb >> 0 & 255;
+          color.push(r / 255, g / 255, b / 255);
+        }
+        if (offset.normal_x !== void 0) {
+          normal.push(parseFloat(line[offset.normal_x]));
+          normal.push(parseFloat(line[offset.normal_y]));
+          normal.push(parseFloat(line[offset.normal_z]));
+        }
+        if (offset.intensity !== void 0) {
+          intensity.push(parseFloat(line[offset.intensity]));
+        }
+        if (offset.label !== void 0) {
+          label.push(parseInt(line[offset.label]));
+        }
+      }
+    }
+    if (PCDheader.data === "binary_compressed") {
+      const sizes = new Uint32Array(data.slice(PCDheader.headerLen, PCDheader.headerLen + 8));
+      const compressedSize = sizes[0];
+      const decompressedSize = sizes[1];
+      const decompressed = decompressLZF(new Uint8Array(data, PCDheader.headerLen + 8, compressedSize), decompressedSize);
+      const dataview = new DataView(decompressed.buffer);
+      const offset = PCDheader.offset;
+      for (let i = 0; i < PCDheader.points; i++) {
+        if (offset.x !== void 0) {
+          const xIndex = PCDheader.fields.indexOf("x");
+          const yIndex = PCDheader.fields.indexOf("y");
+          const zIndex = PCDheader.fields.indexOf("z");
+          position.push(dataview.getFloat32(PCDheader.points * offset.x + PCDheader.size[xIndex] * i, this.littleEndian));
+          position.push(dataview.getFloat32(PCDheader.points * offset.y + PCDheader.size[yIndex] * i, this.littleEndian));
+          position.push(dataview.getFloat32(PCDheader.points * offset.z + PCDheader.size[zIndex] * i, this.littleEndian));
+        }
+        if (offset.rgb !== void 0) {
+          const rgbIndex = PCDheader.fields.indexOf("rgb");
+          color.push(dataview.getUint8(PCDheader.points * offset.rgb + PCDheader.size[rgbIndex] * i + 2) / 255);
+          color.push(dataview.getUint8(PCDheader.points * offset.rgb + PCDheader.size[rgbIndex] * i + 1) / 255);
+          color.push(dataview.getUint8(PCDheader.points * offset.rgb + PCDheader.size[rgbIndex] * i + 0) / 255);
+        }
+        if (offset.normal_x !== void 0) {
+          const xIndex = PCDheader.fields.indexOf("normal_x");
+          const yIndex = PCDheader.fields.indexOf("normal_y");
+          const zIndex = PCDheader.fields.indexOf("normal_z");
+          normal.push(dataview.getFloat32(PCDheader.points * offset.normal_x + PCDheader.size[xIndex] * i, this.littleEndian));
+          normal.push(dataview.getFloat32(PCDheader.points * offset.normal_y + PCDheader.size[yIndex] * i, this.littleEndian));
+          normal.push(dataview.getFloat32(PCDheader.points * offset.normal_z + PCDheader.size[zIndex] * i, this.littleEndian));
+        }
+        if (offset.intensity !== void 0) {
+          const intensityIndex = PCDheader.fields.indexOf("intensity");
+          intensity.push(dataview.getFloat32(PCDheader.points * offset.intensity + PCDheader.size[intensityIndex] * i, this.littleEndian));
+        }
+        if (offset.label !== void 0) {
+          const labelIndex = PCDheader.fields.indexOf("label");
+          label.push(dataview.getInt32(PCDheader.points * offset.label + PCDheader.size[labelIndex] * i, this.littleEndian));
+        }
+      }
+    }
+    if (PCDheader.data === "binary") {
+      const dataview = new DataView(data, PCDheader.headerLen);
+      const offset = PCDheader.offset;
+      for (let i = 0, row = 0; i < PCDheader.points; i++, row += PCDheader.rowSize) {
+        if (offset.x !== void 0) {
+          position.push(dataview.getFloat32(row + offset.x, this.littleEndian));
+          position.push(dataview.getFloat32(row + offset.y, this.littleEndian));
+          position.push(dataview.getFloat32(row + offset.z, this.littleEndian));
+        }
+        if (offset.rgb !== void 0) {
+          color.push(dataview.getUint8(row + offset.rgb + 2) / 255);
+          color.push(dataview.getUint8(row + offset.rgb + 1) / 255);
+          color.push(dataview.getUint8(row + offset.rgb + 0) / 255);
+        }
+        if (offset.normal_x !== void 0) {
+          normal.push(dataview.getFloat32(row + offset.normal_x, this.littleEndian));
+          normal.push(dataview.getFloat32(row + offset.normal_y, this.littleEndian));
+          normal.push(dataview.getFloat32(row + offset.normal_z, this.littleEndian));
+        }
+        if (offset.intensity !== void 0) {
+          intensity.push(dataview.getFloat32(row + offset.intensity, this.littleEndian));
+        }
+        if (offset.label !== void 0) {
+          label.push(dataview.getInt32(row + offset.label, this.littleEndian));
+        }
+      }
+    }
+    const geometry = new BufferGeometry();
+    if (position.length > 0) geometry.setAttribute("position", new Float32BufferAttribute(position, 3));
+    if (normal.length > 0) geometry.setAttribute("normal", new Float32BufferAttribute(normal, 3));
+    if (color.length > 0) geometry.setAttribute("color", new Float32BufferAttribute(color, 3));
+    if (intensity.length > 0) geometry.setAttribute("intensity", new Float32BufferAttribute(intensity, 1));
+    if (label.length > 0) geometry.setAttribute("label", new Int32BufferAttribute(label, 1));
+    geometry.computeBoundingSphere();
+    const material = new PointsMaterial({ size: 5e-3 });
+    if (color.length > 0) {
+      material.vertexColors = true;
+    }
+    return new Points(geometry, material);
+  }
+};
+
+// ../public/static/js/WebGL.js
+function isWebGLAvailable() {
+  try {
+    var canvas = document.createElement("canvas");
+    return !!(window.WebGLRenderingContext && (canvas.getContext("webgl") || canvas.getContext("experimental-webgl")));
+  } catch (e) {
+    return false;
+  }
+}
+function getWebGLErrorMessage() {
+  return this.getErrorMessage(1);
+}
+
+// ../node_modules/three/examples/jsm/controls/TrackballControls.js
+var _changeEvent = { type: "change" };
+var _startEvent = { type: "start" };
+var _endEvent = { type: "end" };
+var TrackballControls = class extends EventDispatcher {
+  constructor(object, domElement) {
+    super();
+    const scope = this;
+    const STATE = { NONE: -1, ROTATE: 0, ZOOM: 1, PAN: 2, TOUCH_ROTATE: 3, TOUCH_ZOOM_PAN: 4 };
+    this.object = object;
+    this.domElement = domElement;
+    this.domElement.style.touchAction = "none";
+    this.enabled = true;
+    this.screen = { left: 0, top: 0, width: 0, height: 0 };
+    this.rotateSpeed = 1;
+    this.zoomSpeed = 1.2;
+    this.panSpeed = 0.3;
+    this.noRotate = false;
+    this.noZoom = false;
+    this.noPan = false;
+    this.staticMoving = false;
+    this.dynamicDampingFactor = 0.2;
+    this.minDistance = 0;
+    this.maxDistance = Infinity;
+    this.minZoom = 0;
+    this.maxZoom = Infinity;
+    this.keys = [
+      "KeyA",
+      "KeyS",
+      "KeyD"
+      /*D*/
+    ];
+    this.mouseButtons = { LEFT: MOUSE.ROTATE, MIDDLE: MOUSE.DOLLY, RIGHT: MOUSE.PAN };
+    this.target = new Vector3();
+    const EPS = 1e-6;
+    const lastPosition = new Vector3();
+    let lastZoom = 1;
+    let _state = STATE.NONE, _keyState = STATE.NONE, _touchZoomDistanceStart = 0, _touchZoomDistanceEnd = 0, _lastAngle = 0;
+    const _eye = new Vector3(), _movePrev = new Vector2(), _moveCurr = new Vector2(), _lastAxis = new Vector3(), _zoomStart = new Vector2(), _zoomEnd = new Vector2(), _panStart = new Vector2(), _panEnd = new Vector2(), _pointers = [], _pointerPositions = {};
+    this.target0 = this.target.clone();
+    this.position0 = this.object.position.clone();
+    this.up0 = this.object.up.clone();
+    this.zoom0 = this.object.zoom;
+    this.handleResize = function() {
+      const box = scope.domElement.getBoundingClientRect();
+      const d = scope.domElement.ownerDocument.documentElement;
+      scope.screen.left = box.left + window.pageXOffset - d.clientLeft;
+      scope.screen.top = box.top + window.pageYOffset - d.clientTop;
+      scope.screen.width = box.width;
+      scope.screen.height = box.height;
+    };
+    const getMouseOnScreen = (function() {
+      const vector = new Vector2();
+      return function getMouseOnScreen2(pageX, pageY) {
+        vector.set(
+          (pageX - scope.screen.left) / scope.screen.width,
+          (pageY - scope.screen.top) / scope.screen.height
+        );
+        return vector;
+      };
+    })();
+    const getMouseOnCircle = (function() {
+      const vector = new Vector2();
+      return function getMouseOnCircle2(pageX, pageY) {
+        vector.set(
+          (pageX - scope.screen.width * 0.5 - scope.screen.left) / (scope.screen.width * 0.5),
+          (scope.screen.height + 2 * (scope.screen.top - pageY)) / scope.screen.width
+          // screen.width intentional
+        );
+        return vector;
+      };
+    })();
+    this.rotateCamera = (function() {
+      const axis = new Vector3(), quaternion = new Quaternion(), eyeDirection = new Vector3(), objectUpDirection = new Vector3(), objectSidewaysDirection = new Vector3(), moveDirection = new Vector3();
+      return function rotateCamera() {
+        moveDirection.set(_moveCurr.x - _movePrev.x, _moveCurr.y - _movePrev.y, 0);
+        let angle = moveDirection.length();
+        if (angle) {
+          _eye.copy(scope.object.position).sub(scope.target);
+          eyeDirection.copy(_eye).normalize();
+          objectUpDirection.copy(scope.object.up).normalize();
+          objectSidewaysDirection.crossVectors(objectUpDirection, eyeDirection).normalize();
+          objectUpDirection.setLength(_moveCurr.y - _movePrev.y);
+          objectSidewaysDirection.setLength(_moveCurr.x - _movePrev.x);
+          moveDirection.copy(objectUpDirection.add(objectSidewaysDirection));
+          axis.crossVectors(moveDirection, _eye).normalize();
+          angle *= scope.rotateSpeed;
+          quaternion.setFromAxisAngle(axis, angle);
+          _eye.applyQuaternion(quaternion);
+          scope.object.up.applyQuaternion(quaternion);
+          _lastAxis.copy(axis);
+          _lastAngle = angle;
+        } else if (!scope.staticMoving && _lastAngle) {
+          _lastAngle *= Math.sqrt(1 - scope.dynamicDampingFactor);
+          _eye.copy(scope.object.position).sub(scope.target);
+          quaternion.setFromAxisAngle(_lastAxis, _lastAngle);
+          _eye.applyQuaternion(quaternion);
+          scope.object.up.applyQuaternion(quaternion);
+        }
+        _movePrev.copy(_moveCurr);
+      };
+    })();
+    this.zoomCamera = function() {
+      let factor;
+      if (_state === STATE.TOUCH_ZOOM_PAN) {
+        factor = _touchZoomDistanceStart / _touchZoomDistanceEnd;
+        _touchZoomDistanceStart = _touchZoomDistanceEnd;
+        if (scope.object.isPerspectiveCamera) {
+          _eye.multiplyScalar(factor);
+        } else if (scope.object.isOrthographicCamera) {
+          scope.object.zoom = MathUtils.clamp(scope.object.zoom / factor, scope.minZoom, scope.maxZoom);
+          if (lastZoom !== scope.object.zoom) {
+            scope.object.updateProjectionMatrix();
+          }
+        } else {
+          console.warn("THREE.TrackballControls: Unsupported camera type");
+        }
+      } else {
+        factor = 1 + (_zoomEnd.y - _zoomStart.y) * scope.zoomSpeed;
+        if (factor !== 1 && factor > 0) {
+          if (scope.object.isPerspectiveCamera) {
+            _eye.multiplyScalar(factor);
+          } else if (scope.object.isOrthographicCamera) {
+            scope.object.zoom = MathUtils.clamp(scope.object.zoom / factor, scope.minZoom, scope.maxZoom);
+            if (lastZoom !== scope.object.zoom) {
+              scope.object.updateProjectionMatrix();
+            }
+          } else {
+            console.warn("THREE.TrackballControls: Unsupported camera type");
+          }
+        }
+        if (scope.staticMoving) {
+          _zoomStart.copy(_zoomEnd);
+        } else {
+          _zoomStart.y += (_zoomEnd.y - _zoomStart.y) * this.dynamicDampingFactor;
+        }
+      }
+    };
+    this.panCamera = (function() {
+      const mouseChange = new Vector2(), objectUp = new Vector3(), pan = new Vector3();
+      return function panCamera() {
+        mouseChange.copy(_panEnd).sub(_panStart);
+        if (mouseChange.lengthSq()) {
+          if (scope.object.isOrthographicCamera) {
+            const scale_x = (scope.object.right - scope.object.left) / scope.object.zoom / scope.domElement.clientWidth;
+            const scale_y = (scope.object.top - scope.object.bottom) / scope.object.zoom / scope.domElement.clientWidth;
+            mouseChange.x *= scale_x;
+            mouseChange.y *= scale_y;
+          }
+          mouseChange.multiplyScalar(_eye.length() * scope.panSpeed);
+          pan.copy(_eye).cross(scope.object.up).setLength(mouseChange.x);
+          pan.add(objectUp.copy(scope.object.up).setLength(mouseChange.y));
+          scope.object.position.add(pan);
+          scope.target.add(pan);
+          if (scope.staticMoving) {
+            _panStart.copy(_panEnd);
+          } else {
+            _panStart.add(mouseChange.subVectors(_panEnd, _panStart).multiplyScalar(scope.dynamicDampingFactor));
+          }
+        }
+      };
+    })();
+    this.checkDistances = function() {
+      if (!scope.noZoom || !scope.noPan) {
+        if (_eye.lengthSq() > scope.maxDistance * scope.maxDistance) {
+          scope.object.position.addVectors(scope.target, _eye.setLength(scope.maxDistance));
+          _zoomStart.copy(_zoomEnd);
+        }
+        if (_eye.lengthSq() < scope.minDistance * scope.minDistance) {
+          scope.object.position.addVectors(scope.target, _eye.setLength(scope.minDistance));
+          _zoomStart.copy(_zoomEnd);
+        }
+      }
+    };
+    this.update = function() {
+      _eye.subVectors(scope.object.position, scope.target);
+      if (!scope.noRotate) {
+        scope.rotateCamera();
+      }
+      if (!scope.noZoom) {
+        scope.zoomCamera();
+      }
+      if (!scope.noPan) {
+        scope.panCamera();
+      }
+      scope.object.position.addVectors(scope.target, _eye);
+      if (scope.object.isPerspectiveCamera) {
+        scope.checkDistances();
+        scope.object.lookAt(scope.target);
+        if (lastPosition.distanceToSquared(scope.object.position) > EPS) {
+          scope.dispatchEvent(_changeEvent);
+          lastPosition.copy(scope.object.position);
+        }
+      } else if (scope.object.isOrthographicCamera) {
+        scope.object.lookAt(scope.target);
+        if (lastPosition.distanceToSquared(scope.object.position) > EPS || lastZoom !== scope.object.zoom) {
+          scope.dispatchEvent(_changeEvent);
+          lastPosition.copy(scope.object.position);
+          lastZoom = scope.object.zoom;
+        }
+      } else {
+        console.warn("THREE.TrackballControls: Unsupported camera type");
+      }
+    };
+    this.reset = function() {
+      _state = STATE.NONE;
+      _keyState = STATE.NONE;
+      scope.target.copy(scope.target0);
+      scope.object.position.copy(scope.position0);
+      scope.object.up.copy(scope.up0);
+      scope.object.zoom = scope.zoom0;
+      scope.object.updateProjectionMatrix();
+      _eye.subVectors(scope.object.position, scope.target);
+      scope.object.lookAt(scope.target);
+      scope.dispatchEvent(_changeEvent);
+      lastPosition.copy(scope.object.position);
+      lastZoom = scope.object.zoom;
+    };
+    function onPointerDown(event) {
+      if (scope.enabled === false) return;
+      if (_pointers.length === 0) {
+        scope.domElement.setPointerCapture(event.pointerId);
+        scope.domElement.addEventListener("pointermove", onPointerMove);
+        scope.domElement.addEventListener("pointerup", onPointerUp);
+      }
+      addPointer(event);
+      if (event.pointerType === "touch") {
+        onTouchStart(event);
+      } else {
+        onMouseDown(event);
+      }
+    }
+    function onPointerMove(event) {
+      if (scope.enabled === false) return;
+      if (event.pointerType === "touch") {
+        onTouchMove(event);
+      } else {
+        onMouseMove(event);
+      }
+    }
+    function onPointerUp(event) {
+      if (scope.enabled === false) return;
+      if (event.pointerType === "touch") {
+        onTouchEnd(event);
+      } else {
+        onMouseUp();
+      }
+      removePointer(event);
+      if (_pointers.length === 0) {
+        scope.domElement.releasePointerCapture(event.pointerId);
+        scope.domElement.removeEventListener("pointermove", onPointerMove);
+        scope.domElement.removeEventListener("pointerup", onPointerUp);
+      }
+    }
+    function onPointerCancel(event) {
+      removePointer(event);
+    }
+    function keydown(event) {
+      if (scope.enabled === false) return;
+      window.removeEventListener("keydown", keydown);
+      if (_keyState !== STATE.NONE) {
+        return;
+      } else if (event.code === scope.keys[STATE.ROTATE] && !scope.noRotate) {
+        _keyState = STATE.ROTATE;
+      } else if (event.code === scope.keys[STATE.ZOOM] && !scope.noZoom) {
+        _keyState = STATE.ZOOM;
+      } else if (event.code === scope.keys[STATE.PAN] && !scope.noPan) {
+        _keyState = STATE.PAN;
+      }
+    }
+    function keyup() {
+      if (scope.enabled === false) return;
+      _keyState = STATE.NONE;
+      window.addEventListener("keydown", keydown);
+    }
+    function onMouseDown(event) {
+      if (_state === STATE.NONE) {
+        switch (event.button) {
+          case scope.mouseButtons.LEFT:
+            _state = STATE.ROTATE;
+            break;
+          case scope.mouseButtons.MIDDLE:
+            _state = STATE.ZOOM;
+            break;
+          case scope.mouseButtons.RIGHT:
+            _state = STATE.PAN;
+            break;
+        }
+      }
+      const state = _keyState !== STATE.NONE ? _keyState : _state;
+      if (state === STATE.ROTATE && !scope.noRotate) {
+        _moveCurr.copy(getMouseOnCircle(event.pageX, event.pageY));
+        _movePrev.copy(_moveCurr);
+      } else if (state === STATE.ZOOM && !scope.noZoom) {
+        _zoomStart.copy(getMouseOnScreen(event.pageX, event.pageY));
+        _zoomEnd.copy(_zoomStart);
+      } else if (state === STATE.PAN && !scope.noPan) {
+        _panStart.copy(getMouseOnScreen(event.pageX, event.pageY));
+        _panEnd.copy(_panStart);
+      }
+      scope.dispatchEvent(_startEvent);
+    }
+    function onMouseMove(event) {
+      const state = _keyState !== STATE.NONE ? _keyState : _state;
+      if (state === STATE.ROTATE && !scope.noRotate) {
+        _movePrev.copy(_moveCurr);
+        _moveCurr.copy(getMouseOnCircle(event.pageX, event.pageY));
+      } else if (state === STATE.ZOOM && !scope.noZoom) {
+        _zoomEnd.copy(getMouseOnScreen(event.pageX, event.pageY));
+      } else if (state === STATE.PAN && !scope.noPan) {
+        _panEnd.copy(getMouseOnScreen(event.pageX, event.pageY));
+      }
+    }
+    function onMouseUp() {
+      _state = STATE.NONE;
+      scope.dispatchEvent(_endEvent);
+    }
+    function onMouseWheel(event) {
+      if (scope.enabled === false) return;
+      if (scope.noZoom === true) return;
+      event.preventDefault();
+      switch (event.deltaMode) {
+        case 2:
+          _zoomStart.y -= event.deltaY * 0.025;
+          break;
+        case 1:
+          _zoomStart.y -= event.deltaY * 0.01;
+          break;
+        default:
+          _zoomStart.y -= event.deltaY * 25e-5;
+          break;
+      }
+      scope.dispatchEvent(_startEvent);
+      scope.dispatchEvent(_endEvent);
+    }
+    function onTouchStart(event) {
+      trackPointer(event);
+      switch (_pointers.length) {
+        case 1:
+          _state = STATE.TOUCH_ROTATE;
+          _moveCurr.copy(getMouseOnCircle(_pointers[0].pageX, _pointers[0].pageY));
+          _movePrev.copy(_moveCurr);
+          break;
+        default:
+          _state = STATE.TOUCH_ZOOM_PAN;
+          const dx = _pointers[0].pageX - _pointers[1].pageX;
+          const dy = _pointers[0].pageY - _pointers[1].pageY;
+          _touchZoomDistanceEnd = _touchZoomDistanceStart = Math.sqrt(dx * dx + dy * dy);
+          const x = (_pointers[0].pageX + _pointers[1].pageX) / 2;
+          const y = (_pointers[0].pageY + _pointers[1].pageY) / 2;
+          _panStart.copy(getMouseOnScreen(x, y));
+          _panEnd.copy(_panStart);
+          break;
+      }
+      scope.dispatchEvent(_startEvent);
+    }
+    function onTouchMove(event) {
+      trackPointer(event);
+      switch (_pointers.length) {
+        case 1:
+          _movePrev.copy(_moveCurr);
+          _moveCurr.copy(getMouseOnCircle(event.pageX, event.pageY));
+          break;
+        default:
+          const position = getSecondPointerPosition(event);
+          const dx = event.pageX - position.x;
+          const dy = event.pageY - position.y;
+          _touchZoomDistanceEnd = Math.sqrt(dx * dx + dy * dy);
+          const x = (event.pageX + position.x) / 2;
+          const y = (event.pageY + position.y) / 2;
+          _panEnd.copy(getMouseOnScreen(x, y));
+          break;
+      }
+    }
+    function onTouchEnd(event) {
+      switch (_pointers.length) {
+        case 0:
+          _state = STATE.NONE;
+          break;
+        case 1:
+          _state = STATE.TOUCH_ROTATE;
+          _moveCurr.copy(getMouseOnCircle(event.pageX, event.pageY));
+          _movePrev.copy(_moveCurr);
+          break;
+        case 2:
+          _state = STATE.TOUCH_ZOOM_PAN;
+          for (let i = 0; i < _pointers.length; i++) {
+            if (_pointers[i].pointerId !== event.pointerId) {
+              const position = _pointerPositions[_pointers[i].pointerId];
+              _moveCurr.copy(getMouseOnCircle(position.x, position.y));
+              _movePrev.copy(_moveCurr);
+              break;
+            }
+          }
+          break;
+      }
+      scope.dispatchEvent(_endEvent);
+    }
+    function contextmenu(event) {
+      if (scope.enabled === false) return;
+      event.preventDefault();
+    }
+    function addPointer(event) {
+      _pointers.push(event);
+    }
+    function removePointer(event) {
+      delete _pointerPositions[event.pointerId];
+      for (let i = 0; i < _pointers.length; i++) {
+        if (_pointers[i].pointerId == event.pointerId) {
+          _pointers.splice(i, 1);
+          return;
+        }
+      }
+    }
+    function trackPointer(event) {
+      let position = _pointerPositions[event.pointerId];
+      if (position === void 0) {
+        position = new Vector2();
+        _pointerPositions[event.pointerId] = position;
+      }
+      position.set(event.pageX, event.pageY);
+    }
+    function getSecondPointerPosition(event) {
+      const pointer = event.pointerId === _pointers[0].pointerId ? _pointers[1] : _pointers[0];
+      return _pointerPositions[pointer.pointerId];
+    }
+    this.dispose = function() {
+      scope.domElement.removeEventListener("contextmenu", contextmenu);
+      scope.domElement.removeEventListener("pointerdown", onPointerDown);
+      scope.domElement.removeEventListener("pointercancel", onPointerCancel);
+      scope.domElement.removeEventListener("wheel", onMouseWheel);
+      scope.domElement.removeEventListener("pointermove", onPointerMove);
+      scope.domElement.removeEventListener("pointerup", onPointerUp);
+      window.removeEventListener("keydown", keydown);
+      window.removeEventListener("keyup", keyup);
+    };
+    this.domElement.addEventListener("contextmenu", contextmenu);
+    this.domElement.addEventListener("pointerdown", onPointerDown);
+    this.domElement.addEventListener("pointercancel", onPointerCancel);
+    this.domElement.addEventListener("wheel", onMouseWheel, { passive: false });
+    window.addEventListener("keydown", keydown);
+    window.addEventListener("keyup", keyup);
+    this.handleResize();
+    this.update();
+  }
+};
+
+// src/singlecell.js
+async function init(arg, holder) {
+  try {
+    const obj = await load_json(arg);
+    validate_obj(obj);
+    obj.genome = arg.genome;
+    obj.holder = holder.style("position", "relative");
+    await init_view(obj);
+    init_controlpanel(obj);
+    await pcd_pipeline(obj);
+    make_legend(arg, obj);
+  } catch (e) {
+    sayerror(holder, e.message || e);
+  }
+}
+async function load_json(arg) {
+  if (!arg.jsonfile) throw ".jsonfile missing";
+  const tmp = await dofetch("textfile", { file: arg.jsonfile });
+  if (tmp.error) throw tmp.error;
+  return JSON.parse(tmp.text);
+}
+function validate_obj(obj) {
+  if (!obj.cells) throw ".cells{} missing";
+  if (!obj.cells.file) throw ".cells.file missing";
+  if (!obj.cells.axis2columnidx) throw ".cells.axis2columnidx missing";
+  if (obj.cells.categories) {
+    if (!Array.isArray(obj.cells.categories)) throw ".cells.categories should be an array";
+    if (obj.cells.categories.length == 0) throw ".cells.categories[] is empty array";
+    for (const c of obj.cells.categories) {
+      if (!Number.isInteger(c.columnidx)) throw "columnidx missing from category " + c;
+      if (c.autocolor) {
+        c.autocolor = ordinal(schemeCategory20);
+      }
+    }
+    if (!Number.isInteger(obj.use_category_index)) {
+      obj.use_category_index = 0;
+    }
+    if (!obj.cells.categories[obj.use_category_index]) throw "use_category_index out of bound";
+    if (!obj.cells.categories[obj.use_category_index].hidden_types)
+      obj.cells.categories[obj.use_category_index].hidden_types = [];
+  }
+  if (obj.gene_expression) {
+    if (!obj.gene_expression.file) throw ".gene_expression.file missing";
+    if (!Number.isInteger(obj.cells.barcodecolumnidx))
+      throw ".gene_expression in use but .cells.barcodecolumnidx is missing";
+  }
+  if (!obj.width) obj.width = window.innerWidth * 0.9;
+  if (!obj.height) obj.height = window.innerHeight * 0.9;
+}
+async function pcd_pipeline(obj) {
+  if (Number.isInteger(obj.use_category_index)) {
+    if (!obj.cells.categories[obj.use_category_index].hidden_types)
+      obj.cells.categories[obj.use_category_index].hidden_types = [];
+  }
+  const data = await load_cell_pcd(obj);
+  obj.data_sphere_r = data.data_sphere_r;
+  if (!obj.camera.position.z) {
+    obj.camera.position.z = obj.data_sphere_r * 3;
+    obj.controls.maxDistance = obj.data_sphere_r * 4;
+    obj.controls.minDistance = obj.data_sphere_r / 10;
+  }
+  const enc = new TextEncoder();
+  const pcd_buffer = enc.encode(data.pcddata).buffer;
+  render_cloud(obj, pcd_buffer);
+  render_controlpanel(obj, data);
+  animate();
+  function animate() {
+    requestAnimationFrame(animate);
+    obj.controls.update();
+    obj.renderer.render(obj.scene, obj.camera);
+  }
+}
+async function load_cell_pcd(obj) {
+  const wait = obj.holder.append("div").style("position", "absolute").style("top", 0).style("left", 0).style("padding", "10px").style("font-size", "1.5rem").text("Loading data...");
+  const arg = {
+    genome: obj.genome.name,
+    textfile: obj.cells.file,
+    delimiter: obj.cells.delimiter || "	",
+    getpcd: {
+      coord: obj.cells.axis2columnidx
+    }
+  };
+  if (Number.isInteger(obj.use_category_index)) {
+    if (!obj.cells.categories) throw "using category index but cells.categories[] missing";
+    const cat = obj.cells.categories[obj.use_category_index];
+    if (!cat) throw "category array index out of bound";
+    arg.getpcd.category_index = cat.columnidx;
+    if (cat.autocolor) {
+      arg.getpcd.category_autocolor = true;
+      if (cat.values_count) arg.getpcd.values_count = cat.values_count;
+    } else if (cat.values) {
+      arg.getpcd.category_customcolor = true;
+      arg.getpcd.cat_values = cat.values;
+    } else {
+      if (!cat.autocolor && !cat.values) throw "categories.values[] are not defined";
+      throw "unknow coloring scheme for category " + cat.name;
+    }
+    if (cat.hidden_types) {
+      arg.hidden_types = cat.hidden_types;
+    }
+    if (obj.background_color) {
+      arg.background_color = obj.background_color;
+    }
+    if (!cat.customorder) {
+      arg.getpcd.category_autoorder = true;
+    } else if (cat.customorder && cat.values) {
+      arg.getpcd.category_customorder = true;
+      arg.getpcd.cat_values = cat.values;
+    } else {
+      if (cat.customorder && !cat.values) throw "categories.values[] are not defined";
+      throw "unknow ordering scheme for category " + cat.name;
+    }
+    obj.menu_button.html(cat.name + "&nbsp;&nbsp;&#9660;");
+  } else if (Number.isInteger(obj.use_gene_index)) {
+    const gene = obj.gene_expression.genes[obj.use_gene_index];
+    obj.menu_button.html("Gene : " + gene.gene + "&nbsp;&nbsp;&#9660;");
+    arg.getpcd.gene_expression = {
+      file: obj.gene_expression.file,
+      barcodecolumnidx: obj.cells.barcodecolumnidx,
+      chr: gene.chr,
+      start: gene.start,
+      stop: gene.stop,
+      autoscale: true,
+      genename: gene.gene,
+      color_min: obj.gene_expression.color_min,
+      color_max: obj.gene_expression.color_max
+    };
+    if (obj.gene_expression.color_no_exp) arg.getpcd.gene_expression.color_no_exp = obj.gene_expression.color_no_exp;
+  } else {
+    throw "unknown method to color the cells";
+  }
+  return dofetch("singlecell", arg).then((data) => {
+    if (data.error) throw data.error;
+    wait.remove();
+    return data;
+  });
+}
+async function init_view(obj) {
+  if (isWebGLAvailable() === false) {
+    obj.holder.node().appendChild(getWebGLErrorMessage());
+    return;
+  }
+  obj.scene = new Scene();
+  if (obj.background_color) {
+    obj.scene.background = new Color(obj.background_color);
+  } else {
+    obj.scene.background = new Color(16777215);
+  }
+  const default_zoom = obj.default_zoom ? 100 - obj.default_zoom : 45;
+  obj.camera = new PerspectiveCamera(default_zoom, obj.width / obj.height, 0.1, 1e3);
+  obj.camera.position.x = obj.canvas_2d ? 0 : 20;
+  obj.camera.position.y = obj.canvas_2d ? 0 : -10;
+  if (obj.canvas_2d) {
+    obj.camera.up.set(0, 1, 0);
+  } else {
+    obj.camera.up.set(0, 0, 1);
+  }
+  obj.renderer = new WebGLRenderer({ antialias: true, preserveDrawingBuffer: true });
+  obj.renderer.setPixelRatio(window.devicePixelRatio);
+  obj.renderer.setSize(obj.width, obj.height);
+  obj.renderer.domElement.style.backgroundColor = "#ffffff";
+  obj.renderer.domElement.style.border = "solid #dddddd 2px";
+  obj.renderer.outputColorSpace = LinearSRGBColorSpace;
+  obj.renderer.toneMapping = NoToneMapping;
+  obj.holder.style("display", "inline-block").style("position", "relative").node().appendChild(obj.renderer.domElement);
+  obj.controls = new TrackballControls(obj.camera, obj.renderer.domElement);
+  obj.controls.rotateSpeed = obj.canvas_2d ? 0 : 2;
+  obj.controls.zoomSpeed = obj.canvas_2d ? 3 : 0.7;
+  obj.controls.panSpeed = obj.canvas_2d ? 3 : 0.7;
+  obj.controls.noZoom = true;
+  obj.controls.noPan = false;
+  obj.controls.staticMoving = true;
+  obj.controls.dynamicDampingFactor = 0.3;
+  obj.scene.add(obj.camera);
+  obj.renderer.render(obj.scene, obj.camera);
+  obj.controls.update();
+}
+function render_cloud(obj, pcd_buffer) {
+  obj.scene.children.forEach(function(v, i) {
+    if (v.material) {
+      v.material.dispose();
+      v.geometry.dispose();
+      obj.scene.remove(v);
+    }
+  });
+  const loader = new PCDLoader();
+  const points = loader.parse(pcd_buffer, "");
+  const newMat = new PointsMaterial({
+    size: points.material.size,
+    vertexColors: true,
+    color: 16777215
+  });
+  points.material = newMat;
+  points.material.vertexColors = true;
+  points.material.color.set(16777215);
+  points.material.needsUpdate = true;
+  if (obj.point_size) {
+    points.material.size = obj.point_size;
+  } else {
+    points.material.size = obj.canvas_2d ? 0.3 : 0.05;
+  }
+  obj.scene.add(points);
+  obj.center = points.geometry.boundingSphere.center;
+  obj.controls.target.set(obj.center.x, obj.center.y, obj.center.z);
+  obj.controls.update();
+}
+function init_controlpanel(obj) {
+  obj.menu = new Menu();
+  obj.menu.d.style("padding", "3px");
+  obj.settings = new Menu();
+  obj.settings.d.style("padding", "3px");
+  const panel = obj.holder.append("div").style("padding", "10px").style("position", "absolute").style("border-radius", "5px").style("top", "20px").style("right", "20px").style("background-color", "#dddddd");
+  obj.menu_button = panel.append("button").style("display", "inline-block").style("padding", "4px").on("click", () => make_menu(obj));
+  const minimize_btn = obj.minimize_btn = panel.append("div").style("margin-left", "10px").style("display", "inline-block").style("padding-left", "0px").style("padding-right", "2px").style("float", "right").style("font-size", ".6em").classed("active", obj.menu_minimized ? true : false).text(obj.menu_minimized ? " SHOW" : " HIDE").on("click", () => {
+    obj.minimize_btn.classed("active", obj.minimize_btn.classed("active") ? false : true);
+    if (obj.minimize_btn.classed("active")) {
+      obj.minimize_btn.text(" SHOW");
+      obj.menu_output.style("display", "none");
+    } else {
+      obj.minimize_btn.text(" HIDE");
+      obj.menu_output.style("display", "block");
+    }
+  }).on("mouseover", () => {
+    minimize_btn.style("text-decoration", "underline");
+  }).on("mouseout", () => {
+    minimize_btn.style("text-decoration", "none");
+  });
+  obj.use_background_color = 0;
+  const config_btn = obj.settings_btn = panel.append("div").style("margin-left", "10px").style("display", "inline-block").style("padding-left", "3px").style("padding-right", "3px").style("float", "right").style("font-size", ".6em").text("CONFIG").on("click", () => make_settings(obj)).on("mouseover", () => {
+    config_btn.style("text-decoration", "underline");
+  }).on("mouseout", () => {
+    config_btn.style("text-decoration", "none");
+  });
+  obj.menu_output = panel.append("div").style("margin-top", "10px").style("display", obj.menu_minimized ? "none" : "block");
+  obj.show_zoom = true;
+}
+function render_controlpanel(obj, data) {
+  obj.menu_output.selectAll("*").remove();
+  if (data.category2color) {
+    const top_row = obj.menu_output.append("div").style("margin", "2px");
+    const select_all_checkbox = top_row.append("input").attr("type", "checkbox").style("margin-right", "10px").style("vertical-align", "top").style("display", "inline-block").on("change", () => {
+      if (select_all_checkbox.node().checked) {
+        obj.cells.categories[obj.use_category_index].hidden_types = [];
+        pcd_pipeline(obj);
+      } else {
+        for (const type in data.category2color) {
+          obj.cells.categories[obj.use_category_index].hidden_types.push(type);
+        }
+        pcd_pipeline(obj);
+      }
+    });
+    if (obj.cells.categories[obj.use_category_index].hidden_types.length == 0) {
+      select_all_checkbox.property("checked", 1);
+    }
+    top_row.append("span").text("Select All").style("font-size", ".8em").attr("font-family", font);
+    for (const type in data.category2color) {
+      const row = obj.menu_output.append("div").style("margin", "2px");
+      const checkbox = row.append("input").attr("type", "checkbox").property("checked", 1).style("margin-right", "10px").style("vertical-align", "top").style("display", "inline-block").on("change", () => {
+        if (obj.cells.categories[obj.use_category_index].hidden_types.includes(type)) {
+          const index = obj.cells.categories[obj.use_category_index].hidden_types.indexOf(type);
+          if (index !== -1) obj.cells.categories[obj.use_category_index].hidden_types.splice(index, 1);
+          checkbox.property("checked", 1);
+        } else {
+          obj.cells.categories[obj.use_category_index].hidden_types.push(type);
+        }
+        pcd_pipeline(obj);
+      });
+      if (obj.cells.categories[obj.use_category_index].hidden_types.includes(type)) {
+        checkbox.property("checked", 0);
+      }
+      row.append("div").style("display", "inline-block").style("height", "15px").style("width", "15px").style("background-color", data.category2color[type]).style("margin-right", "10px");
+      row.append("span").text(type).attr("font-family", font);
+      row.append("span").html("&nbsp;n=" + data.categorycount[type]).attr("font-family", font).style("font-size", ".8em").style("float", "right").style("color", "#777");
+    }
+  } else if (data.maxexpvalue) {
+    const scale_height = 30;
+    const scale_width = 150;
+    const scale_div = obj.menu_output.append("div").style("margin", "10px").style("width", "120px").style("height", "100px");
+    scale_div.append("div").text("Gene Expression " + obj.gene_expression.datatype).style("text-align", "center").style("width", "150px").style("margin-bottom", "20px");
+    const svg = scale_div.append("svg").append("g");
+    const colorRange = [obj.gene_expression.color_max, obj.gene_expression.color_min];
+    const colorScale = linear().range(colorRange).domain([data.minexpvalue, data.maxexpvalue]);
+    const defs = svg.append("defs");
+    const linearGradient = defs.append("linearGradient").attr("id", "linear-gradient");
+    linearGradient.append("stop").attr("offset", "0%").attr("stop-color", colorScale(data.maxexpvalue));
+    linearGradient.append("stop").attr("offset", "100%").attr("stop-color", colorScale(data.minexpvalue));
+    svg.append("rect").attr("x", 0).attr("y", 0).attr("width", scale_width).attr("height", scale_height).attr("transform", "translate(12, 0)").style("fill", "url(#linear-gradient)");
+    const y = linear().range([0, scale_width]).domain([data.minexpvalue, data.maxexpvalue]);
+    const legendAxis = axisBottom().scale(y).ticks(5);
+    svg.append("g").attr("class", "legend axis").attr("transform", "translate(12," + scale_height + ")").call(legendAxis);
+    const stats_div = obj.menu_output.append("div").style("padding-bottom", "20px").style("text-align", "center");
+    stats_div.append("p").style("font-size", "13px").style("margin", "2px 0").html("<b>Cells with Expression Data</b> ");
+    stats_div.append("p").style("font-size", "13px").style("margin", "2px 0").html(data.numbercellwithgeneexp + " / " + data.numbercelltotal);
+    const no_exp_div = stats_div.append("div").style("display", "block").style("margin-top", "10px");
+    no_exp_div.append("div").style("display", "inline-block").style("height", "15px").style("width", "15px").style("background-color", obj.gene_expression.color_no_exp ? obj.gene_expression.color_no_exp : "#2C2C2C").style("margin-right", "10px");
+    no_exp_div.append("div").style("display", "inline-block").style("font-size", "13px").html(" Cells without Expression");
+    const boxplot_div = obj.menu_output.append("div");
+    boxplot_div.append("div").style("display", "block").style("padding", "5px").html("Violinplot / Boxplot of </br> Expression by");
+    const boxplot_cat_select = boxplot_div.append("select").style("display", "block");
+    boxplot_cat_select.append("option").attr("value", "none").text("-- Select--");
+    if (obj.cells.categories) {
+      obj.cells.categories.forEach((category, i) => {
+        boxplot_cat_select.append("option").attr("value", category.columnidx).text(category.name);
+      });
+    }
+    boxplot_cat_select.on("change", () => {
+      const gene = obj.gene_expression.genes[obj.use_gene_index];
+      const cat = obj.cells.categories[parseInt(boxplot_cat_select.node().selectedIndex) - 1];
+      const arg = {
+        genome: obj.genome.name,
+        getgeneboxplot: {
+          expfile: obj.gene_expression.file,
+          chr: gene.chr,
+          start: gene.start,
+          stop: gene.stop,
+          genename: gene.gene,
+          cellfile: obj.cells.file,
+          barcodecolumnidx: obj.cells.barcodecolumnidx,
+          categorycolumnidx: parseInt(boxplot_cat_select.node().value),
+          delimiter: obj.cells.delimiter || "	",
+          category_customorder: cat.customorder && cat.values ? true : false,
+          category_autoorder: !cat.customorder ? true : false,
+          cat_values: cat.values,
+          values_count: cat.values_count
+        }
+      };
+      dofetch("singlecell", arg).then((data2) => {
+        if (data2.error) throw data2.error;
+        obj.box_plot = new Menu();
+        make_plot(data2, obj, boxplot_cat_select.node().value);
+      });
+    });
+  }
+  make_zoom_panel(obj);
+}
+function make_zoom_panel(obj) {
+  if (obj.show_zoom) {
+    const zoom_div = obj.menu_output.append("div").style("display", "block").text("Zoom").style("margin", "10px 5px 5px 5px").style("padding-top", "10px").style("border-top", "1px solid #929292");
+    const zoom_hide_btn = zoom_div.append("div").style("margin-left", "10px").style("display", "inline-block").style("padding-left", "0px").style("padding-right", "2px").style("float", "right").style("font-size", ".6em").text("MOVE TO CONFIG").on("click", () => {
+      zoom_div.node().remove();
+      obj.show_zoom = false;
+    }).on("mouseover", () => {
+      zoom_hide_btn.style("text-decoration", "underline");
+    }).on("mouseout", () => {
+      zoom_hide_btn.style("text-decoration", "none");
+    });
+    obj.zoom_slider = zoom_div.append("input").style("display", "block").style("padding", "5px").attr("type", "range").attr("min", 1).attr("max", 100).attr("value", obj.camera.fov).style("direction", "rtl").on("change", () => {
+      obj.camera.fov = parseInt(obj.zoom_slider.node().value);
+      obj.camera.updateProjectionMatrix();
+    }).on("mousedown", (event) => {
+      event.stopPropagation();
+    });
+  }
+}
+function make_menu(obj) {
+  obj.menu.clear().showunder(obj.menu_button.node());
+  if (obj.cells.categories) {
+    obj.cells.categories.forEach((category, i) => {
+      if (i != obj.use_category_index) {
+        obj.menu.d.append("div").text(category.name).attr("class", "sja_menuoption").on("click", async () => {
+          obj.menu.hide();
+          obj.use_category_index = i;
+          pcd_pipeline(obj);
+        }).append("span").attr("font-family", font).style("display", category.values_count ? "inline-block" : "none").style("font-size", ".8em").style("float", "right").style("color", "#777").style("padding", "3px 5px").html(category.values_count ? "&nbsp;n=" + category.values_count : "");
+      }
+    });
+  }
+  if (obj.gene_expression) {
+    obj.menu.d.append("div").text("Gene expression").attr("class", "sja_menuoption").on("click", () => {
+      obj.menu.clear();
+      const gene_search_div = obj.menu.d.append("div").style("padding", "10px");
+      gene_searchbox({
+        div: gene_search_div.append("div"),
+        resultdiv: gene_search_div.append("div"),
+        genome: obj.genome.name,
+        callback: async (genename) => {
+          const gmlst = await findgenemodel_bysymbol(obj.genome.name, genename);
+          if (gmlst && gmlst[0]) {
+            const gm = gmlst[0];
+            if (!obj.gene_expression.genes) obj.gene_expression.genes = [];
+            const geneidx = obj.gene_expression.genes.findIndex((i) => i.gene == genename);
+            if (geneidx == -1) {
+              obj.gene_expression.genes.push({
+                gene: genename,
+                chr: gm.chr,
+                start: gm.start,
+                stop: gm.stop
+              });
+              obj.use_gene_index = obj.gene_expression.genes.length - 1;
+            } else {
+              obj.use_gene_index = geneidx;
+            }
+          }
+          obj.use_category_index = null;
+          obj.menu.hide();
+          pcd_pipeline(obj);
+        }
+      });
+    });
+    obj.menu.d.append("div").text("Multi-Gene Heatmap").attr("class", "sja_menuoption").on("click", () => {
+      heatmap_menu(obj);
+    });
+    if (obj.gene_expression.genes) {
+      if (obj.gene_expression.genes.length > 1) {
+        obj.menu.d.append("div").style("padding", "5px 10px").text("Previously Selected");
+      }
+      obj.gene_expression.genes.forEach((gene, i) => {
+        if (i != obj.use_gene_index) {
+          obj.menu.d.append("div").text("Gene : " + gene.gene).attr("class", "sja_menuoption").on("click", async () => {
+            obj.menu.hide();
+            obj.use_category_index = null;
+            obj.use_gene_index = i;
+            pcd_pipeline(obj);
+          });
+        }
+      });
+    }
+  }
+}
+function make_settings(obj) {
+  obj.settings.clear().showunder(obj.settings_btn.node());
+  const back_color_div = obj.settings.d.append("div").style("display", "block").text("Background Color").style("margin", "5px");
+  const black_div = back_color_div.append("div").style("margin", "5px").style("display", "block");
+  const name = Math.random(), idblack = Math.random(), idwhite = Math.random();
+  const inputblack = black_div.append("input").attr("type", "radio").style("display", "inline-block").attr("name", name).attr("id", idblack).on("change", toggle_background);
+  black_div.append("label").style("display", "inline-block").style("font-size", ".8em").text("Black").style("padding-left", "10px").attr("for", idblack);
+  const white_div = back_color_div.append("div").style("margin", "5px").style("display", "block");
+  const inputwhite = white_div.append("input").attr("type", "radio").style("display", "inline-block").attr("name", name).attr("id", idwhite).on("change", toggle_background);
+  white_div.append("label").style("display", "inline-block").style("font-size", ".8em").text("White").style("padding-left", "10px").attr("for", idwhite);
+  if (obj.use_background_color == 0) {
+    inputwhite.property("checked", 1);
+  } else {
+    inputblack.property("checked", 1);
+  }
+  function toggle_background() {
+    const isblack = obj.background_color == "black";
+    obj.scene.background = new Color(isblack ? 16777215 : 0);
+    obj.use_background_color = isblack ? 0 : 1;
+    obj.background_color = isblack ? "white" : "black";
+  }
+  const point_size_div = obj.settings.d.append("div").style("display", "block").text("Point Size").style("margin", "20px 5px");
+  const point_size_slider = point_size_div.append("input").style("display", "block").style("padding", "5px").attr("type", "range").attr("min", 1).attr("max", 70).attr("value", obj.scene.children[1].material.size * 100).on("change", () => {
+    obj.scene.children[1].material.size = point_size_slider.node().value / 100;
+  });
+  if (obj.show_zoom == false) {
+    const zoom_div = obj.settings.d.append("div").style("display", "block").text("Zoom").style("margin", "20px 5px");
+    const zoom_hide_btn = zoom_div.append("div").style("margin-left", "10px").style("display", "inline-block").style("padding-left", "0px").style("padding-right", "2px").style("float", "right").style("font-size", ".6em").html("MOVE TO </br>LEGEND PANEL").on("click", () => {
+      zoom_div.node().remove();
+      obj.show_zoom = true;
+      make_zoom_panel(obj);
+    }).on("mouseover", () => {
+      zoom_hide_btn.style("text-decoration", "underline");
+    }).on("mouseout", () => {
+      zoom_hide_btn.style("text-decoration", "none");
+    });
+    obj.zoom_slider = zoom_div.append("input").style("display", "block").style("padding", "5px").attr("type", "range").attr("min", 5).attr("max", 70).attr("value", obj.camera.fov).style("direction", "rtl").on("change", () => {
+      obj.camera.fov = parseInt(obj.zoom_slider.node().value);
+      obj.camera.updateProjectionMatrix();
+    });
+  }
+  obj.settings.d.append("div").style("margin", "5px").text("Panning");
+  obj.settings.d.append("div").style("font-size", ".8em").style("text-align", "center").style("margin-bottom", "10px").html('<p style="margin:3px;">Right mouse click </br>+ Mouse move</p>');
+  if (!obj.canvas_2d) {
+    obj.settings.d.append("div").style("margin", "5px").text("Rotate");
+    obj.settings.d.append("div").style("font-size", ".8em").style("text-align", "center").style("margin-bottom", "10px").html('<p style="margin:3px;">Left mouse click </br>+ Mouse move</p>');
+  }
+  obj.settings.d.append("div").attr("class", "sja_menuoption").text("Reset view").style("width", "80px").style("margin", "auto").style("margin-top", "15px").style("margin-bottom", "15px").on("click", () => {
+    inputwhite.property("checked", 1);
+    obj.scene.background = new Color(obj.background_color ? obj.background_color : 16777215);
+    point_size_slider.node().value = obj.point_size ? obj.point_size * 100 : obj.canvas_2d ? 30 : 5;
+    obj.scene.children[1].material.size = obj.point_size ? obj.point_size : obj.canvas_2d ? 0.3 : 0.05;
+    obj.camera.position.z = obj.data_sphere_r * 3;
+    obj.camera.position.x = obj.canvas_2d ? 0 : 20;
+    obj.camera.position.y = obj.canvas_2d ? 0 : -10;
+    const cam_fov_default = 45;
+    obj.camera.fov = parseInt(cam_fov_default);
+    obj.camera.updateProjectionMatrix();
+    obj.zoom_slider.node().value = cam_fov_default;
+    if (obj.canvas_2d) {
+      obj.camera.up.set(0, 1, 0);
+    } else {
+      obj.camera.up.set(0, 0, 1);
+    }
+    obj.controls.target.set(obj.center.x, obj.center.y, obj.center.z);
+  });
+  const screenshot_btn = obj.settings.d.append("div").attr("class", "sja_menuoption").style("padding", "5px").style("width", "80px").style("margin", "auto").style("margin-top", "15px").style("margin-bottom", "15px").html("<b>&#10697;</b> Capture").on("mousedown", () => {
+    const imgData = obj.renderer.domElement.toDataURL();
+    let imgNode = document.createElement("img");
+    imgNode.src = imgData;
+    screenshot_btn.append("span").style("display", "none").html(
+      '<a download="scRNA_' + (/* @__PURE__ */ new Date()).toLocaleString() + '.png" href="' + imgNode.src + '" title="ImageName">Camera</a>'
+    );
+  }).on("mouseup", () => {
+    screenshot_btn.select("a").node().click();
+    screenshot_btn.selectAll("span").remove();
+  });
+}
+function heatmap_menu(obj) {
+  obj.menu.clear();
+  obj.gene_expression.heatmap_genes = [];
+  obj.use_heatmap_category_index = null;
+  const heatmap_menu_div = obj.menu.d.append("div").style("display", "block").style("padding", "10px");
+  const genes_div = heatmap_menu_div.append("div").style("display", "block");
+  const gene_search_div = genes_div.append("div").style("display", "inline-block").style("vertical-align", "top").style("padding", "10px");
+  gene_search_div.append("div").style("display", "block").style("padding-bottom", "5px").text("Add Genes");
+  gene_search_div.append("textarea").attr("rows", "4").attr("cols", "20").attr("placeholder", "Type gene names seperated by space");
+  const catagory_div = heatmap_menu_div.append("div");
+  catagory_div.append("div").style("display", "block").style("padding-bottom", "5px").style("padding-left", "10px").text("Heatmap by");
+  const cat_select = catagory_div.append("select").style("display", "block").style("margin-left", "10px");
+  cat_select.append("option").attr("value", "none").text("-- Select--");
+  if (obj.cells.categories) {
+    obj.cells.categories.forEach((category, i) => {
+      cat_select.append("option").attr("value", category.columnidx).text(category.name);
+    });
+  }
+  cat_select.on("change", () => {
+    obj.use_heatmap_category_index = parseInt(cat_select.node().value);
+  });
+  heatmap_menu_div.append("button").text("Heatmap").style("display", "block").style("float", "right").style("margin", "5px").on("click", async () => {
+    const input_genelist = gene_search_div.select("textarea").node().value;
+    const genelist = input_genelist.split(" ");
+    for (const gene of genelist) {
+      const gmlst = await findgenemodel_bysymbol(obj.genome.name, gene);
+      if (gmlst && gmlst[0]) {
+        const gm = gmlst[0];
+        if (!obj.gene_expression.heatmap_genes) obj.gene_expression.heatmap_genes = [];
+        const geneidx = obj.gene_expression.heatmap_genes.findIndex((i) => i.gene == gene);
+        if (geneidx == -1) {
+          obj.gene_expression.heatmap_genes.push({
+            gene,
+            chr: gm.chr,
+            start: gm.start,
+            stop: gm.stop
+          });
+        }
+      }
+    }
+    const arg = {
+      genome: obj.genome.name,
+      getheatmap: {
+        expfile: obj.gene_expression.file,
+        gene_list: obj.gene_expression.heatmap_genes,
+        cellfile: obj.cells.file,
+        barcodecolumnidx: obj.cells.barcodecolumnidx,
+        categorycolumnidx: parseInt(cat_select.node().value),
+        delimiter: obj.cells.delimiter || "	"
+      }
+    };
+    dofetch("singlecell", arg).then((data) => {
+      if (data.error) throw data.error;
+      obj.menu.hide();
+      make_heatmap(data, obj, cat_select.node().value);
+    });
+  });
+}
+function make_plot(data, obj, colidx) {
+  const gene = obj.gene_expression.genes[obj.use_gene_index];
+  const pane = newpane({ x: 600, y: 400 });
+  const cat = obj.cells.categories.find((x) => x.columnidx == colidx);
+  pane.header.text("Violinplot/Boxplot for " + gene.gene + " Expression by " + cat.name);
+  const control_panel = pane.pane.append("div").style("margin", "10px 10px 10px 15px");
+  const svg = pane.pane.append("svg").style("margin", "10px");
+  const plot_select = control_panel.append("select").style("display", "inline-block");
+  plot_select.append("option").attr("value", "violin").text("Violin Plot");
+  plot_select.append("option").attr("value", "box").text("Box Plot");
+  plot_select.on("change", () => {
+    apply();
+  });
+  const cell_select_div = control_panel.append("div").style("display", "inline-block").style("padding-left", "15px").text("Cells without expression");
+  const cell_select = cell_select_div.append("select").style("display", "inline-block").style("margin-left", "5px");
+  cell_select.append("option").attr("value", "include").text("Include");
+  cell_select.append("option").attr("value", "exclude").text("Exclude");
+  cell_select.on("change", () => {
+    apply();
+  });
+  make_violin_plot(data, svg);
+  function apply() {
+    const gene2 = obj.gene_expression.genes[obj.use_gene_index];
+    const arg = {
+      genome: obj.genome.name,
+      getgeneboxplot: {
+        expfile: obj.gene_expression.file,
+        chr: gene2.chr,
+        start: gene2.start,
+        stop: gene2.stop,
+        genename: gene2.gene,
+        cellfile: obj.cells.file,
+        barcodecolumnidx: obj.cells.barcodecolumnidx,
+        categorycolumnidx: parseInt(colidx),
+        delimiter: obj.cells.delimiter || "	",
+        category_customorder: cat.customorder && cat.values ? true : false,
+        category_autoorder: !cat.customorder ? true : false,
+        cat_values: cat.values,
+        values_count: cat.values_count
+      }
+    };
+    if (cell_select.node().value == "exclude") {
+      arg.getgeneboxplot.exclude_cells = true;
+    }
+    dofetch("singlecell", arg).then((data2) => {
+      if (data2.error) throw data2.error;
+      if (plot_select.node().value == "box") make_box_plot(data2, svg);
+      else if (plot_select.node().value == "violin") make_violin_plot(data2, svg);
+    });
+  }
+}
+function make_violin_plot(data, svg) {
+  svg.selectAll("*").remove();
+  let box_height = 50, box_width = 200, barspace = 2, axis_height = 30;
+  const label_width = get_max_labelwidth(data.boxplots, svg);
+  const x_scale = linear().range([0, box_width]).domain([data.minexpvalue, data.maxexpvalue]);
+  const y_scale = linear().range([box_height, 0]).domain([0, 1]);
+  const svg_height = data.boxplots.length * (box_height + barspace) + axis_height;
+  const svg_width = box_width + label_width + 20;
+  svg.transition().attr("width", svg_width).attr("height", svg_height);
+  if (data.boxplots) {
+    data.boxplots.forEach((boxplot, i) => {
+      const g = svg.append("g").attr("transform", "translate(" + label_width + "," + (i * (box_height + barspace) + axis_height) + ")");
+      const xlabel = g.append("text").text(boxplot.category + " (" + boxplot.numberofcells + ")").attr("transform", "translate(-4," + box_height / 2 + ")").attr("text-anchor", "end").attr("font-size", 15).attr("font-family", font).attr("dominant-baseline", "central");
+      if (boxplot.density) {
+        const density_max = Math.max(...boxplot.density);
+        const line = line_default().x(function(d, j) {
+          return x_scale(j * data.maxexpvalue / boxplot.density.length);
+        }).y(function(d) {
+          return y_scale(d / density_max) / 2;
+        }).curve(monotoneX);
+        const area = area_default().x(function(d, j) {
+          return x_scale(j * data.maxexpvalue / boxplot.density.length);
+        }).y0(function(d) {
+          const temp = y_scale(d / density_max) / 2;
+          return box_height - temp;
+        }).y1(function(d) {
+          return y_scale(d / density_max) / 2;
+        }).curve(monotoneX);
+        g.append("path").datum(boxplot.density).attr("class", "area").attr("d", area).style("fill", boxplot.color).style("stroke", "black").style("stroke-width", 0.5);
+      }
+    });
+    const legendAxis = axisTop().scale(x_scale).ticks(5);
+    svg.append("g").attr("class", "legend axis").attr("transform", "translate(" + label_width + "," + (axis_height - 10) + ")").call(legendAxis);
+  }
+}
+function make_box_plot(data, svg) {
+  svg.selectAll("*").remove();
+  let box_height = 36, box_width = 200, barspace = 16, axis_height = 30;
+  const label_width = get_max_labelwidth(data.boxplots, svg);
+  const x_scale = linear().range([0, box_width]).domain([data.minexpvalue, data.maxexpvalue]);
+  const y_scale = linear().range([box_height, 0]).domain([0, 1]);
+  const svg_height = data.boxplots.length * (box_height + barspace) + axis_height;
+  const svg_width = box_width + label_width + 20;
+  svg.transition().attr("width", svg_width).attr("height", svg_height);
+  if (data.boxplots) {
+    data.boxplots.forEach((boxplot, i) => {
+      const g = svg.append("g").attr("transform", "translate(" + label_width + "," + (i * (box_height + barspace) + axis_height) + ")");
+      const xlabel = g.append("text").text(boxplot.category + " (" + boxplot.numberofcells + ")").attr("transform", "translate(-4," + box_height / 2 + ")").attr("text-anchor", "end").attr("font-size", 15).attr("font-family", font).attr("dominant-baseline", "central");
+      if (boxplot.p75) {
+        g.append("line").attr("x1", x_scale(boxplot.w1)).attr("y1", box_height / 2).attr("x2", x_scale(boxplot.w2)).attr("y2", box_height / 2).attr("stroke-width", 2).attr("stroke", "black");
+        g.append("rect").attr("x", x_scale(boxplot.p25)).attr("y", 0).attr("width", x_scale(boxplot.p75 - boxplot.p25)).attr("height", box_height).attr("fill", boxplot.color);
+        g.append("line").attr("x1", x_scale(boxplot.w1)).attr("y1", 0).attr("x2", x_scale(boxplot.w1)).attr("y2", box_height).attr("stroke-width", 2).attr("stroke", "black");
+        g.append("line").attr("x1", x_scale(boxplot.p50)).attr("y1", 0).attr("x2", x_scale(boxplot.p50)).attr("y2", box_height).attr("stroke-width", 2).attr("stroke", "white");
+        g.append("line").attr("x1", x_scale(boxplot.w2)).attr("y1", 0).attr("x2", x_scale(boxplot.w2)).attr("y2", box_height).attr("stroke-width", 2).attr("stroke", "black");
+        if (boxplot.out) {
+          for (const outlier of boxplot.out) {
+            g.append("circle").attr("cx", x_scale(outlier.value)).attr("cy", box_height / 2).attr("r", 2).attr("fill", "#901739");
+          }
+        }
+      }
+    });
+    const legendAxis = axisTop().scale(x_scale).ticks(5);
+    svg.append("g").attr("class", "legend axis").attr("transform", "translate(" + label_width + "," + (axis_height - 10) + ")").call(legendAxis);
+  }
+}
+function make_heatmap(data, obj, colidx) {
+  const pane = newpane({ x: 600, y: 400 });
+  const cat = obj.cells.categories.find((x) => x.columnidx == colidx);
+  pane.header.text("Heatmap for Gene Expression by " + cat.name);
+  const svg = pane.pane.append("svg").style("margin", "10px");
+  let gene_list = [];
+  for (const gene of data.gene_heatmap) gene_list.push(gene.genename);
+  let means = [];
+  data.gene_heatmap.forEach((gene, i) => {
+    data.gene_heatmap[i].heatmap.forEach((category) => {
+      means.push(category.mean);
+    });
+  });
+  const max_mean = Math.max(...means);
+  let categories = [];
+  for (const category of data.gene_heatmap[0].heatmap)
+    categories.push(category.category + " (" + category.numberofcells + ")");
+  let box_height = 20, box_width = 80, barspace = 2, gene_lable_height = 30, legend_width = 60;
+  const label_width = get_max_labelwidth(data.gene_heatmap[0].heatmap, svg);
+  const svg_height = (box_height + barspace) * categories.length + gene_lable_height;
+  const svg_width = (box_width + barspace) * gene_list.length + label_width + legend_width + 20;
+  svg.transition().attr("width", svg_width).attr("height", svg_height);
+  const x_scale = band().range([0, (box_width + barspace) * gene_list.length]).domain(gene_list).padding(0.05);
+  svg.append("g").style("font-size", 15).attr("transform", "translate(" + label_width + ",0)").call(axisBottom(x_scale).tickSize(0)).select(".domain").remove();
+  const y_scale = band().range([(box_height + barspace) * categories.length, 0]).domain(categories).padding(0.05);
+  svg.append("g").style("font-size", 15).attr("transform", "translate(" + label_width + "," + gene_lable_height + ")").call(axisLeft(y_scale).tickSize(0)).select(".domain").remove();
+  var myColor = sequential().interpolator(plasma).domain([0, max_mean]);
+  const div = pane.pane.append("div").style("position", "absolute").attr("class", "tooltip").style("background-color", "white").style("border", "solid").style("border-width", "2px").style("border-radius", "5px").style("padding", "5px").style("opacity", 0);
+  data.gene_heatmap.forEach((gene, i) => {
+    data.gene_heatmap[i].heatmap.forEach((category, j) => {
+      const g = svg.append("g").attr("transform", "translate(" + label_width + "," + gene_lable_height + ")");
+      g.append("rect").attr("x", x_scale(gene.genename)).attr("y", y_scale(category.category + " (" + category.numberofcells + ")")).attr("width", x_scale.bandwidth()).attr("height", y_scale.bandwidth()).style("fill", myColor(category.mean)).style("stroke-width", 4).style("stroke", "none").style("opacity", 0.8).on("mouseover", function(event) {
+        div.transition().duration(200).style("opacity", 0.9);
+        div.html("Mean Expression: " + category.mean).style("left", pointer_default(event, this)[0] + 70 + "px").style("top", pointer_default(event, this)[1] + 20 + "px");
+      }).on("mouseout", function() {
+        div.transition().duration(500).style("opacity", 0);
+      });
+    });
+  });
+  const legend_data = myColor.ticks(10).reverse();
+  legend_data.unshift(max_mean.toFixed(2));
+  const legend = svg.selectAll(".legend").data(legend_data).enter().append("g").attr("class", "legend").attr("transform", function(d, i) {
+    return "translate(" + (svg_width - legend_width) + "," + (30 + i * 20) + ")";
+  });
+  legend.append("rect").attr("width", 20).attr("height", 20).style("fill", myColor).style("opacity", 0.8);
+  legend.append("text").attr("x", 26).attr("y", 10).attr("dy", ".35em").text(String);
+}
+function get_max_labelwidth(items, svg) {
+  let textwidth = 0;
+  for (const i of items) {
+    svg.append("text").text(i.category + " (" + i.numberofcells + ")").attr("font-family", font).attr("font-size", 15).each(function() {
+      textwidth = Math.max(textwidth, this.getBBox().width);
+    }).remove();
+  }
+  return textwidth + 4;
+}
+async function make_legend(arg, obj) {
+  if (!arg.legendimg) return;
+  const img_div = obj.holder.append("div").style("margin-top", "5px");
+  obj.legendimg = arg.legendimg;
+  obj.legend = {
+    holder: img_div,
+    legendcolor: "#7D6836"
+  };
+  let shown = !arg.foldlegend;
+  img_div.append("div").text("LEGEND").attr("class", "sja_clb").style("display", "inline-block").style("font-size", ".7em").style("color", obj.legend.legendcolor).style("font-family", font).on("click", () => {
+    if (shown) {
+      shown = false;
+      disappear(div2);
+    } else {
+      shown = true;
+      appear(div2);
+    }
+  });
+  const div2 = obj.holder.append("div").style("border-top", "solid 1px " + obj.legend.legendcolor).style("background-color", "#FCFBF7");
+  obj.legend.holder = div2.append("table").style("border-spacing", "15px").style("border-collapse", "separate");
+  const [tr, td] = legend_newrow(obj, obj.legendimg.name || "");
+  const data = await dofetch2("img?file=" + obj.legendimg.file);
+  if (data.error) {
+    td.text(data.error);
+    return;
+  }
+  let fold = true;
+  const img = td.append("img").attr("class", "sja_clbb").attr("src", data.src).style("height", "80px");
+  img.on("click", () => {
+    if (fold) {
+      fold = false;
+      img.transition().style("height", obj.legendimg.height ? obj.legendimg.height + "px" : "auto");
+    } else {
+      fold = true;
+      img.transition().style("height", "80px");
+    }
+  });
+}
+export {
+  init
+};
+//# sourceMappingURL=singlecell-MOSYT3RI.js.map