@sjcrh/proteinpaint-client 2.181.0 → 2.182.0

package/dist/chunk-ILF2GKBY.js.map

@@ -0,0 +1,7 @@
+{
+  "version": 3,
+  "sources": ["../src/app.mdsjson.js", "../gdc/launch.ts", "../src/app.parseurl.js"],
+  "sourcesContent": ["import * as client from './client'\n\n/*\n********************** EXPORTED\ninit_mdsjson\nvalidate_mdsjson\nget_json_tk\nget_scatterplot_data\n*/\n\nexport async function init_mdsjson(file_str, url_str) {\n\tlet json_files = [],\n\t\tjson_urls = []\n\n\tif (file_str && file_str.includes(',')) json_files = file_str.split(',')\n\telse if (file_str) json_files.push(file_str)\n\telse if (url_str && url_str.includes(',')) json_urls = url_str.split(',')\n\telse if (url_str) json_urls.push(url_str)\n\n\tconst tklst = []\n\tif (json_files.length) {\n\t\tconst json_url = undefined\n\t\tfor (const json_file of json_files) {\n\t\t\ttklst.push(await tklst_pipeline(json_file, json_url))\n\t\t}\n\t} else if (json_urls.length) {\n\t\tconst json_file = undefined\n\t\tfor (const json_url of json_urls) {\n\t\t\ttklst.push(await tklst_pipeline(json_file, json_url))\n\t\t}\n\t}\n\n\treturn tklst\n}\n\nasync function tklst_pipeline(json_file, json_url) {\n\tconst obj = await mdsjson_parse(json_file, json_url)\n\tvalidate_mdsjson(obj)\n\tconst tk = get_json_tk(obj)\n\treturn tk\n}\n\nasync function mdsjson_parse(json_file, json_url) {\n\tif (json_file !== undefined && json_file == '') throw '.jsonfile missing'\n\tif (json_url !== undefined && json_url == '') throw '.jsonurl missing'\n\n\tlet tmp\n\tif (json_file !== undefined) tmp = await client.dofetch('textfile', { file: json_file })\n\telse if (json_url !== undefined) tmp = await client.dofetch('urltextfile', { url: json_url })\n\tif (tmp.error) {\n\t\tthrow tmp.error\n\t}\n\treturn JSON.parse(tmp.text)\n}\n\nexport function validate_mdsjson(obj) {\n\tif (!obj) throw 'file is missing'\n\tif (!obj.type) throw 'dataset type is missing'\n\tconst svcnvfile = obj.svcnvfile || obj.svcnvurl\n\tconst vcffile = obj.vcffile || obj.vcfurl\n\tif (!svcnvfile && !vcffile) throw 'vcf or cnv file/url is required'\n\tif (Object.keys(obj).filter(x => x.includes('expression')).length) {\n\t\tif (!obj.expressionfile && !obj.expressionurl) throw 'expression file/url is missing'\n\t}\n\tif (Object.keys(obj).filter(x => x.includes('rnabam')).length) {\n\t\tif (!obj.rnabamfile && !obj.rnabamurl) throw 'rnabam file/url is missing'\n\t}\n\tif (obj.sampleset) {\n\t\tfor (const sample of obj.sampleset) {\n\t\t\tif (obj.sampleset.length != 1 && !sample.name) throw 'sampleset name is missing'\n\t\t\tif (!sample.samples) throw 'sampleset samples[] is missing'\n\t\t}\n\t}\n\tif (obj.sample2assaytrack) {\n\t\tfor (const [sample, assaylst] of Object.entries(obj.sample2assaytrack)) {\n\t\t\tif (!assaylst.length) throw 'assay[] missing for ' + sample\n\t\t\tfor (const assay of assaylst) {\n\t\t\t\tif (!assay.name) throw 'assay name is missing for ' + sample\n\t\t\t\tif (!assay.type) throw 'assay type is missing for ' + sample\n\t\t\t}\n\t\t}\n\t}\n\n\tif (obj.groupsamplebyattr) {\n\t\tif (!obj.groupsamplebyattr.attrlst) return '.attrlst[] missing from groupsamplebyattr'\n\t\tif (obj.groupsamplebyattr.attrlst.length == 0) return 'groupsamplebyattr.attrlst[] empty array'\n\n\t\tfor (const attr of obj.groupsamplebyattr.attrlst) {\n\t\t\tif (!attr.k) return 'k missing from one of groupsamplebyattr.attrlst[]'\n\t\t}\n\n\t\tif (obj.groupsamplebyattr.sortgroupby) {\n\t\t\tif (!obj.groupsamplebyattr.sortgroupby.key) return '.key missing from .sortgroupby'\n\t\t\tif (!obj.groupsamplebyattr.sortgroupby.order) return '.order[] missing from .sortgroupby'\n\t\t\tif (!Array.isArray(obj.groupsamplebyattr.sortgroupby.order)) return '.order must be an array'\n\t\t\t// values of order[] is not validated\n\t\t}\n\t\tif (!obj.groupsamplebyattr.attrnamespacer) obj.groupsamplebyattr.attrnamespacer = ', '\n\t}\n\n\tif (obj.fixedgeneexpression) {\n\t\tfor (const gene of obj.fixedgeneexpression) {\n\t\t\tif (!gene.gene) throw 'gene missing in fixedgeneexpression array'\n\t\t}\n\t}\n\n\t// hidden classes for vcf file\n\tif (obj.vcf) {\n\t\tif (!obj.vcf.hiddenclass) throw 'hiddenclasses[] missing from .vcf'\n\t}\n}\n\nexport function get_json_tk(tkobj) {\n\tconst track = {\n\t\ttype: tkobj.type,\n\t\tname: tkobj.name\n\t}\n\n\t// dense or full\n\tif (tkobj.isdense == 'true' || tkobj.isdense == true || tkobj.isfull === false) track.isdense = true\n\telse if (tkobj.isfull) track.isfull = true\n\n\t// svcnv file\n\tif (tkobj.svcnvfile) track.file = tkobj.svcnvfile\n\telse if (tkobj.svcnvurl) track.url = tkobj.svcnvurl\n\n\t// expressionrank\n\tif (Object.keys(tkobj).filter(x => x.includes('expression')).length) {\n\t\ttrack.checkexpressionrank = {\n\t\t\tfile: tkobj.expressionfile,\n\t\t\turl: tkobj.expressionurl\n\t\t}\n\t}\n\n\t// vcf\n\tif (Object.keys(tkobj).filter(x => x.includes('vcf')).length) {\n\t\ttrack.checkvcf = {\n\t\t\tfile: tkobj.vcffile,\n\t\t\turl: tkobj.vcfurl\n\t\t}\n\t}\n\n\t// hidden mutation classes\n\tif (tkobj.vcf) {\n\t\tif (tkobj.vcf.hiddenclass) {\n\t\t\ttrack.vcf = []\n\t\t\ttrack.vcf.hiddenclass = tkobj.vcf.hiddenclass\n\t\t}\n\t}\n\n\t// rna bam\n\tif (Object.keys(tkobj).filter(x => x.includes('rnabam')).length) {\n\t\ttrack.checkrnabam = {\n\t\t\tfile: tkobj.rnabamfile,\n\t\t\turl: tkobj.rnabamurl\n\t\t}\n\t}\n\n\t// sampleset\n\tif (tkobj.sampleset) {\n\t\ttrack.sampleset = tkobj.sampleset\n\t}\n\n\t// SampleAssayTrack\n\tif (tkobj.sample2assaytrack) {\n\t\ttrack.sample2assaytrack = tkobj.sample2assaytrack\n\t}\n\n\tif (tkobj.groupsamplebyattr) {\n\t\ttrack.groupsamplebyattr = tkobj.groupsamplebyattr\n\t}\n\n\t// fixed panel of gene expression\n\ttrack.fixedgeneexpression = tkobj.fixedgeneexpression\n\t// show all samples\n\ttrack.getallsamples = tkobj.getallsamples\n\n\t// cnv cutoff settings\n\ttrack.valueCutoff = tkobj.cnvValueCutoff !== undefined ? tkobj.cnvValueCutoff : undefined\n\ttrack.bplengthUpperLimit = tkobj.cnvLengthUpperLimit !== undefined ? tkobj.cnvLengthUpperLimit : undefined\n\n\t// loh cutoff settings\n\ttrack.segmeanValueCutoff = tkobj.segmeanValueCutoff !== undefined ? tkobj.segmeanValueCutoff : undefined\n\ttrack.lohLengthUpperLimit = tkobj.lohLengthUpperLimit !== undefined ? tkobj.lohLengthUpperLimit : undefined\n\n\t// multihide labels\n\ttrack.multihidelabel_vcf = tkobj.multihidelabel_vcf !== undefined ? tkobj.multihidelabel_vcf : undefined\n\ttrack.multihidelabel_fusion = tkobj.multihidelabel_fusion !== undefined ? tkobj.multihidelabel_fusion : undefined\n\ttrack.multihidelabel_sv = tkobj.multihidelabel_sv !== undefined ? tkobj.multihidelabel_sv : undefined\n\n\ttrack.legend_vorigin = tkobj.legend_vorigin\n\n\treturn track\n}\n\nexport async function get_scatterplot_data(json_file, json_url) {\n\tlet data = {}\n\tconst obj = await mdsjson_parse(json_file, json_url)\n\tdata.mdssamplescatterplot = obj\n\treturn data\n}\n", "/* launch from runpp() call. GDC react wrappers in the GFF repo use this method, to launch apps in gdc portal\non matching with a flag, imports corresponding plot script, and returns api object to runpp()\nwhen no flags are matched, returns undefined\n*/\nexport async function mayLaunchGdcPlotFromRunpp(arg, app) {\n\tif (arg.geneSearch4GDCmds3) {\n\t\tconst _ = await import('./lollipop.js')\n\t\treturn await _.init(arg, app.holder0, app.genomes)\n\t}\n\tif (arg.launchGdcMatrix) {\n\t\tconst _ = await import('./oncomatrix.js')\n\t\treturn await _.init(arg, app.holder0, app.genomes)\n\t}\n\tif (arg.launchGdcHierCluster) {\n\t\tconst _ = await import('./geneExpClustering.js')\n\t\treturn await _.init(arg, app.holder0, app.genomes)\n\t}\n\tif (arg.launchGdcMaf) {\n\t\tconst _ = await import('./maf.js')\n\t\treturn await _.gdcMAFui(arg, app.holder0)\n\t}\n\tif (arg.launchGdcGrin2) {\n\t\tconst _ = await import('./grin2.ts')\n\t\treturn await _.gdcGRIN2ui(arg, app.holder0)\n\t}\n\tif (arg.launchGdcScRNAseq) {\n\t\tconst _ = await import('./singlecell.ts')\n\t\treturn await _.init(arg, app.holder0, app.genomes)\n\t}\n\tif (arg.launchGdcScApp) {\n\t\tconst _ = await import('./sc.ts')\n\t\treturn await _.init(arg, app.holder0, app.genomes)\n\t}\n\tif (arg.launchGdcCorrelation) {\n\t\tconst _ = await import('./correlation.ts')\n\t\treturn await _.init(arg, app.holder0, app.genomes)\n\t}\n\tif (arg.launchGdcDE) {\n\t\tconst _ = await import('./DE.ts')\n\t\treturn await _.init(arg, app.holder0, app.genomes)\n\t}\n\tif (arg.gdcbamslice) {\n\t\tconst _ = await import('./bam.js')\n\t\targ.gdcbamslice.filter0 = arg.filter0\n\t\treturn await _.bamsliceui(arg.gdcbamslice, app.holder0, app.genomes)\n\t}\n}\n\n/* launch from url param; this is for local testing and not used in gdc portal\nreturns true for a match\n*/\nexport async function mayLaunchGdcPlotFromUrlparam(urlp, arg) {\n\tif (urlp.has('gdcbamslice')) {\n\t\t// for local testing, not used in gdc portal\n\t\tconst _ = await import('./bam.js')\n\t\t_.bamsliceui(\n\t\t\t{\n\t\t\t\tdebugmode: arg.debugmode,\n\t\t\t\tstream2download: urlp.has('stream2download') // for testing only, launch the app in \"download mode\", will not visualize\n\t\t\t} as any,\n\t\t\targ.holder,\n\t\t\targ.genomes\n\t\t)\n\t\treturn true\n\t}\n\tif (urlp.has('gdcmaf')) {\n\t\t// for local testing, not used in gdc portal\n\t\tconst _ = await import('./maf.js')\n\t\tconst p: any = {\n\t\t\tdebugmode: arg.debugmode\n\t\t}\n\t\tif (urlp.has('filter0')) p.filter0 = urlp.get('filter0')\n\t\t_.gdcMAFui(p, arg.holder)\n\t\treturn true\n\t}\n\tif (urlp.has('gdcgrin2')) {\n\t\t// for local testing, not used in gdc portal\n\t\tconst _ = await import('./grin2.ts')\n\t\tconst p: any = {\n\t\t\tdebugmode: arg.debugmode\n\t\t}\n\t\tif (urlp.has('filter0')) p.filter0 = urlp.get('filter0')\n\t\t_.gdcGRIN2ui(p, arg.holder)\n\t\treturn true\n\t}\n\tif (urlp.has('gdccorrelation')) {\n\t\t// for local testing, not used in gdc portal\n\t\tconst _ = await import('./correlation.ts')\n\t\tconst p: any = {\n\t\t\tdebugmode: arg.debugmode\n\t\t}\n\t\tif (urlp.has('filter0')) p.filter0 = urlp.get('filter0')\n\t\t_.init(p, arg.holder, arg.genomes)\n\t\treturn true\n\t}\n}\n", "import blockinit from './block.init'\nimport * as client from './client'\nimport { loadstudycohort } from './tp.init'\nimport { string2pos } from './coord'\nimport * as mdsjson from './app.mdsjson'\nimport { getSavedToken } from '#common/dofetch'\nimport urlmap from '#common/urlmap'\nimport { first_genetrack_tolist } from '#common/1stGenetk'\nimport { parentCorsMessage, childCorsMessage } from '#common/embedder-helpers'\nimport { sayerror } from '#dom'\nimport { copyMerge } from '#rx'\nimport { mayLaunchGdcPlotFromUrlparam } from '../gdc/launch.ts'\n/*\n********************** EXPORTED\nparse()\nget_tklst()\n*/\n\nexport async function parse(arg) {\n\t/*\narg\n\t.jwt\n\t.genomes{}\n\t.hostURL\n\t.variantPageCall_snv\n\t.samplecart\n\t.holder\n\t.debugmode\n\nupon error, throw err message as a string\n*/\n\tconst urlp = urlmap()\n\tconst features = JSON.parse(sessionStorage.getItem('optionalFeatures'))\n\n\tif (urlp.has('appcard')) {\n\t\tconst ad = await import('../appdrawer/adSandbox')\n\t\tconst cardJsonFile = urlp.get('appcard')\n\t\tconst example = urlp.get('example')\n\t\tconst re = await client.dofetch2('/cards/index.json')\n\t\targ.app.drawer.opts.genomes = arg.genomes\n\t\targ.app.drawer.opts.fromApp = true\n\t\t//Quick fix to launch the sandbox within the current openSandbox code\n\t\targ.app.drawer.opts.app = {\n\t\t\tcardsPath: 'cards'\n\t\t}\n\t\tconst element = re.elements.findIndex(\n\t\t\tt =>\n\t\t\t\tt.sandboxJson == cardJsonFile ||\n\t\t\t\tt.sandboxHtml == cardJsonFile ||\n\t\t\t\tt.name.toUpperCase().includes(cardJsonFile.toUpperCase())\n\t\t)\n\n\t\t//Check if track/app can be shown on this server\n\t\t//If not show error message\n\t\tif (re.elements[element]?.configFeature) {\n\t\t\tif (!features[re.elements[element].configFeature]) {\n\t\t\t\tsayerror(arg.holder, `This track or app is not enabled on this site.`)\n\t\t\t\treturn\n\t\t\t}\n\t\t}\n\n\t\tif (example) {\n\t\t\targ.app.drawer.opts.example = example\n\t\t}\n\n\t\tif (element <= 0) {\n\t\t\tconst nestedCards = [...re.elements.filter(e => e.type == 'nestedCard')]\n\t\t\tlet element, c\n\t\t\tnestedCards.findIndex(t => {\n\t\t\t\tfor (const [i, child] of t.children.entries()) {\n\t\t\t\t\tif (\n\t\t\t\t\t\tchild.sandboxJson == cardJsonFile ||\n\t\t\t\t\t\tchild.sandboxHtml == cardJsonFile ||\n\t\t\t\t\t\tchild.name.toUpperCase().includes(cardJsonFile.toUpperCase())\n\t\t\t\t\t) {\n\t\t\t\t\t\telement = t\n\t\t\t\t\t\tc = i\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t})\n\t\t\tif (!element) {\n\t\t\t\tsayerror(arg.holder, `Invalid app card.`)\n\t\t\t\treturn\n\t\t\t}\n\t\t\tad.openSandbox(element.children[c], arg.app.drawer.opts)\n\t\t} else {\n\t\t\tad.openSandbox(re.elements[element], arg.app.drawer.opts)\n\t\t}\n\t\treturn\n\t}\n\n\tif (await mayLaunchGdcPlotFromUrlparam(urlp, arg)) return // gdc plot launched\n\n\tif (urlp.has('termdb')) {\n\t\tconst value = urlp.get('termdb')\n\t\tconst state = typeof value === 'string' ? JSON.parse(value) : value\n\t\tconst opts = {\n\t\t\tholder: arg.holder,\n\t\t\tstate: copyMerge(state, arg.state || {})\n\t\t}\n\t\tconst _ = await import('../termdb/app')\n\t\tconst subapp = _.appInit(opts)\n\t\treturn subapp\n\t}\n\n\tif (urlp.has('massnative')) {\n\t\t/* ?massnative=hg38-test,TermdbTest\n\t\talternative url for mass={\"genome\":\"hg38-test\",\"dslabel\":\"TermdbTest\"}\n\t\ttidier to include in manuscript\n\t\tno customization supported, though later additional fields may be appended to customize something\n\t\tit is intended that the dataset should carry essential customizations so the link opens mass ui with expected customizations\n\t\t*/\n\t\tconst value = urlp.get('massnative')\n\t\tconst [genomename, dslabel] = value.split(',')\n\t\tif (!genomename || !dslabel) throw 'value is not \"genome,dslabel\"'\n\t\tconst opts = {\n\t\t\tholder: arg.holder,\n\t\t\tgenome: arg.genomes[genomename],\n\t\t\tstate: copyMerge(\n\t\t\t\t{\n\t\t\t\t\tgenome: genomename,\n\t\t\t\t\tdslabel\n\t\t\t\t},\n\t\t\t\targ.state || {}\n\t\t\t),\n\t\t\tpkgver: arg.app.pkgver,\n\t\t\tlaunchDate: arg.app.launchDate\n\t\t}\n\t\tif (!opts.genome) throw 'invalid genome'\n\t\tchildCorsMessage(opts)\n\n\t\tconst _ = await import('../mass/app')\n\t\tconst subapp = await _.appInit(opts)\n\t\treturn subapp\n\t}\n\n\tif (urlp.has('mass')) {\n\t\tconst value = urlp.get('mass')\n\t\tconst state = typeof value === 'string' ? JSON.parse(value) : value\n\t\tconst opts = {\n\t\t\tdebug: arg.app.debugmode,\n\t\t\tholder: arg.holder,\n\t\t\tstate: copyMerge(state, arg.state || {}),\n\t\t\tpkgver: arg.app.pkgver,\n\t\t\tlaunchDate: arg.app.launchDate\n\t\t}\n\t\tif (state.genome) {\n\t\t\topts.genome = arg.genomes[state.genome]\n\t\t} else if (state?.vocab?.genome) {\n\t\t\topts.genome = arg.genomes[state.vocab.genome]\n\t\t}\n\t\tchildCorsMessage(opts)\n\n\t\tconst _ = await import('../mass/app')\n\t\tconst subapp = await _.appInit(opts)\n\t\treturn subapp\n\t}\n\n\tif (urlp.has('mass-session-file') || urlp.has('mass-session-url')) {\n\t\tlet opts\n\t\tif (urlp.has('mass-session-file')) {\n\t\t\tconst file = urlp.get('mass-session-file')\n\t\t\tconst d = await client.dofetch3(`/textfile`, {\n\t\t\t\tmethod: 'POST',\n\t\t\t\tbody: JSON.stringify({ file })\n\t\t\t})\n\t\t\tif (typeof d != 'object') throw 'data not object'\n\t\t\tif (d.error) throw d.error\n\t\t\tif (!d.text) throw 'data.text missing'\n\t\t\tconst state = JSON.parse(d.text)\n\n\t\t\tif (features.overrideEmbedderHostInMassSession) {\n\t\t\t\t// on local dev, set this to override \"embedder{}\" setting in session file\n\t\t\t\t// to prevent redirecting to portal site and test the session with local pp\n\t\t\t\tstate.embedder.host = features.overrideEmbedderHostInMassSession\n\t\t\t\tstate.embedder.origin = 'http://' + features.overrideEmbedderHostInMassSession\n\t\t\t\tstate.embedder.href = `http://${features.overrideEmbedderHostInMassSession}/`\n\t\t\t}\n\n\t\t\tif (state.embedder?.origin && state.embedder.origin != window.location.origin) {\n\t\t\t\tparentCorsMessage({ state })\n\t\t\t\treturn\n\t\t\t}\n\n\t\t\topts = {\n\t\t\t\tdebug: arg.app.debugmode,\n\t\t\t\tholder: arg.holder,\n\t\t\t\tstate,\n\t\t\t\tgenome: arg.genomes[state.vocab.genome],\n\t\t\t\tpkgver: arg.app.pkgver,\n\t\t\t\tlaunchDate: arg.app.launchDate\n\t\t\t}\n\t\t} else if (urlp.has('mass-session-url')) {\n\t\t\tconst url = urlp.get('mass-session-url')\n\t\t\tconst d = await client.dofetch3('/urltextfile', {\n\t\t\t\tmethod: 'POST',\n\t\t\t\tbody: JSON.stringify({ url })\n\t\t\t})\n\t\t\tif (typeof d != 'object') throw 'data not object'\n\t\t\tif (d.error) throw d.error\n\t\t\tif (!d.text) throw 'data.text missing'\n\t\t\tconst state = JSON.parse(d.text)\n\n\t\t\tif (state.embedder?.origin && state.embedder.origin != window.location.origin) {\n\t\t\t\tparentCorsMessage({ state })\n\t\t\t\treturn\n\t\t\t}\n\n\t\t\topts = {\n\t\t\t\tdebug: arg.app.debugmode,\n\t\t\t\tholder: arg.holder,\n\t\t\t\tstate: copyMerge(state, arg.state || {}),\n\t\t\t\tgenome: arg.genomes[state.vocab.genome],\n\t\t\t\tpkgver: arg.app.pkgver,\n\t\t\t\tlaunchDate: arg.app.launchDate\n\t\t\t}\n\t\t}\n\t\tconst _ = await import('../mass/app')\n\t\tconst subapp = _.appInit(opts)\n\t\treturn subapp\n\t}\n\n\tif (urlp.has('mass-session-id')) {\n\t\tconst id = urlp.get('mass-session-id')\n\t\tconst src = urlp.get('src')\n\t\tlet res\n\t\tif (src == 'browser') {\n\t\t\tconst json = localStorage.getItem('savedMassSessions')\n\t\t\tconst savedSessions = JSON.parse(json)\n\t\t\tres = { state: savedSessions[id] }\n\t\t} else {\n\t\t\tconst fetchOpts = { headers: {}, body: { id } }\n\t\t\tif (src == 'cred') {\n\t\t\t\tconst dslabel = urlp.get('dslabel')\n\t\t\t\tconst route = urlp.get('route')\n\t\t\t\tfetchOpts.body.dslabel = dslabel\n\t\t\t\tfetchOpts.body.route = route\n\t\t\t\tfetchOpts.body.route = route\n\t\t\t\tconst jwt = getSavedToken(dslabel, route)\n\t\t\t\tif (jwt) fetchOpts.headers.authorization = `Bearer ${btoa(jwt)}`\n\t\t\t}\n\t\t\tres = await client.dofetch3(`/massSession`, fetchOpts)\n\t\t\tif (res.error) throw res.error\n\t\t}\n\t\tconst embedder = res.state?.embedder\n\t\tif (embedder?.origin && embedder.origin != window.location.origin) {\n\t\t\tparentCorsMessage(res)\n\t\t\treturn\n\t\t}\n\t\tconst opts = {\n\t\t\tdebug: arg.app.debugmode,\n\t\t\tholder: arg.holder,\n\t\t\tstate: copyMerge(res.state, arg.state || {}),\n\t\t\tgenome: arg.genomes[res.state.vocab.genome],\n\t\t\tsessionDaysLeft: res.sessionDaysLeft,\n\t\t\tsessionId: id,\n\t\t\tpkgver: arg.app.pkgver,\n\t\t\tlaunchDate: arg.app.launchDate\n\t\t}\n\t\tconst _ = await import('../mass/app')\n\t\tconst subapp = _.appInit(opts)\n\t\treturn subapp\n\t}\n\n\tif (urlp.has('genome') && arg.selectgenome) {\n\t\tconst n = urlp.get('genome')\n\t\tconst genome_options = [...arg.selectgenome.node().childNodes]\n\t\tconst selectedIndex = genome_options.findIndex(d => d.value == n)\n\t\tif (selectedIndex == -1) {\n\t\t\tsayerror(\n\t\t\t\targ.holder,\n\t\t\t\t`Invalid genome: ${n}. Please provide an available genome from this list: ${genome_options\n\t\t\t\t\t.map(d => d.value)\n\t\t\t\t\t.join(', ')\n\t\t\t\t\t.replace(/,(?=[^,]*$)/, ', or')}`\n\t\t\t)\n\t\t\treturn\n\t\t}\n\t\targ.selectgenome.node().selectedIndex = selectedIndex\n\t\targ.selectgenome.node().dispatchEvent(new Event('change'))\n\t}\n\n\tif (urlp.has('hicfile') || urlp.has('hicurl')) {\n\t\t// whole-genome view\n\t\tlet file, url, name\n\t\tif (urlp.has('hicfile')) {\n\t\t\tfile = urlp.get('hicfile')\n\t\t\tname = file.split('/').pop()\n\t\t} else {\n\t\t\turl = urlp.get('hicurl')\n\t\t\tname = url.split('/').pop()\n\t\t}\n\t\tconst gn = urlp.get('genome')\n\t\tif (!gn) throw 'genome is required for hic'\n\t\tconst genome = arg.genomes[gn]\n\t\tif (!genome) throw 'invalid genome'\n\t\tconst hic = {\n\t\t\tgenome,\n\t\t\tfile,\n\t\t\turl,\n\t\t\tname, //.basename(file || url),\n\t\t\thostURL: arg.hostURL,\n\t\t\tenzyme: urlp.get('enzyme'),\n\t\t\tholder: arg.holder\n\t\t}\n\t\tconst _ = await import('../tracks/hic/HicApp')\n\t\tawait _.hicInit(hic)\n\t\treturn\n\t}\n\n\t//////////// legacy, may be replaced by sampleScatter, kept for existing views on vizcom\n\tif (urlp.has('singlecell')) {\n\t\tif (!urlp.has('genome')) throw '\"genome\" is required for \"singlecell\"'\n\t\tconst genomename = urlp.get('genome')\n\t\tconst genomeobj = arg.genomes[genomename]\n\t\tif (!genomeobj) throw 'invalid genome: ' + genomename\n\n\t\tconst _ = await import('./singlecell')\n\t\t_.init(\n\t\t\t{\n\t\t\t\tgenome: genomeobj,\n\t\t\t\tjsonfile: urlp.get('singlecell')\n\t\t\t},\n\t\t\targ.holder\n\t\t)\n\t\treturn\n\t}\n\n\tif (urlp.has('mavbfile')) {\n\t\tif (!urlp.has('genome')) throw '\"genome\" is required for \"mavb\"'\n\t\tconst genomename = urlp.get('genome')\n\t\tconst genome = arg.genomes[genomename]\n\t\tif (!genome) throw 'invalid genome: ' + genomename\n\t\tconst _ = await import('./mavb')\n\t\t_.mavbparseinput(\n\t\t\t{\n\t\t\t\tgenome,\n\t\t\t\thostURL: arg.hostURL,\n\t\t\t\tfile: urlp.get('mavbfile')\n\t\t\t},\n\t\t\t() => {},\n\t\t\targ.holder,\n\t\t\targ.jwt\n\t\t)\n\t\treturn\n\t}\n\n\tif (urlp.has('mavburl')) {\n\t\tif (!urlp.has('genome')) throw '\"genome\" is required for \"mavb\"'\n\t\tconst genomename = urlp.get('genome')\n\t\tconst genome = arg.genomes[genomename]\n\t\tif (!genome) throw 'invalid genome: ' + genomename\n\t\tconst _ = await import('./mavb')\n\t\t_.mavbparseinput(\n\t\t\t{\n\t\t\t\tgenome,\n\t\t\t\thostURL: arg.hostURL,\n\t\t\t\turl: urlp.get('mavburl')\n\t\t\t},\n\t\t\t() => {},\n\t\t\targ.holder,\n\t\t\targ.jwt\n\t\t)\n\t\treturn\n\t}\n\n\t//////////// legacy, replaced by sampleScatter (just need to support adhoc data), kept for existing views on vizcom\n\tif (urlp.has('scatterplot')) {\n\t\tif (!urlp.has('genome')) throw '\"genome\" is required for \"scatterplot\"'\n\t\tconst genomename = urlp.get('genome')\n\t\tconst genome = arg.genomes[genomename]\n\t\tif (!genome) throw 'invalid genome: ' + genomename\n\n\t\tlet plot_data\n\t\tif (urlp.has('mdsjson') || urlp.has('mdsjsonurl')) {\n\t\t\tconst url_str = urlp.get('mdsjsonurl')\n\t\t\tconst file_str = urlp.get('mdsjson')\n\t\t\tplot_data = await mdsjson.get_scatterplot_data(file_str, url_str)\n\t\t}\n\t\tif (urlp.has('tsnejson')) {\n\t\t\tconst file_str = urlp.get('tsnejson')\n\t\t\tconst data = await client.dofetch('textfile', { file: file_str })\n\t\t\tif (data.error) throw data.error\n\t\t\telse if (data.text) {\n\t\t\t\tplot_data = {\n\t\t\t\t\tmdssamplescatterplot: {\n\t\t\t\t\t\tanalysisdata: JSON.parse(data.text)\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t}\n\t\t}\n\n\t\t// if genome is defined in url, pass it to samplescatterplot\n\t\tplot_data.mdssamplescatterplot.genome = genome\n\t\tconst _ = await import('./mds.samplescatterplot')\n\t\t_.init(plot_data.mdssamplescatterplot, arg.holder, false)\n\t\treturn\n\t}\n\n\tif (urlp.has('block')) {\n\t\tif (!urlp.has('genome')) throw 'missing genome for block'\n\t\tconst genomename = urlp.get('genome')\n\t\tconst genomeobj = arg.genomes[genomename]\n\t\tif (!genomeobj) throw 'invalid genome: ' + genomename\n\n\t\tconst par = {\n\t\t\tnobox: 1,\n\t\t\thostURL: arg.hostURL,\n\t\t\tjwt: arg.jwt,\n\t\t\tholder: arg.holder,\n\t\t\tgenome: genomeobj,\n\t\t\tdogtag: genomename,\n\t\t\tdebugmode: arg.debugmode\n\t\t}\n\n\t\tlet position = null\n\t\tlet rglst = null\n\n\t\tif (urlp.has('position')) {\n\t\t\t// can be multiple regions joined by ;\n\t\t\t// first region is main panel, rest of regions are subpanels\n\n\t\t\tconst lst = urlp.get('position').split(';')\n\t\t\tif (lst[0]) {\n\t\t\t\t// if first region is blank, do not parse; it will be assigned with defaultcoord\n\t\t\t\tconst tmp = lst[0].split(/[:-]/)\n\t\t\t\tconst chr = tmp[0]\n\t\t\t\tconst start = Number.parseInt(tmp[1])\n\t\t\t\tconst stop = Number.parseInt(tmp[2])\n\t\t\t\tif (!chr) throw 'chr missing'\n\t\t\t\tif (Number.isNaN(start) || Number.isNaN(stop)) throw 'Invalid start/stop value in position'\n\t\t\t\t// valid position\n\t\t\t\tposition = { chr, start, stop }\n\t\t\t}\n\n\t\t\tconst subpanels = [] // collect rest of regions into this array\n\t\t\tfor (let i = 1; i < lst.length; i++) {\n\t\t\t\tif (!lst[i]) continue // skip blank string\n\t\t\t\tconst tmp = lst[i].split(/[:-]/)\n\t\t\t\tconst chr = tmp[0]\n\t\t\t\tconst start = Number.parseInt(tmp[1])\n\t\t\t\tconst stop = Number.parseInt(tmp[2])\n\t\t\t\tif (!chr) throw 'subpanel chr missing'\n\t\t\t\tif (Number.isNaN(start) || Number.isNaN(stop)) throw 'Invalid start/stop value in subpanel position'\n\t\t\t\t// valid pos\n\t\t\t\tsubpanels.push({\n\t\t\t\t\tchr,\n\t\t\t\t\tstart,\n\t\t\t\t\tstop,\n\t\t\t\t\twidth: 600,\n\t\t\t\t\tleftborder: 'rgba(200,0,0,.1)',\n\t\t\t\t\tleftpad: 5\n\t\t\t\t})\n\t\t\t}\n\t\t\tif (subpanels.length) {\n\t\t\t\t// has valid subpanels\n\t\t\t\tpar.subpanels = subpanels\n\t\t\t}\n\t\t}\n\n\t\tif (urlp.has('regions')) {\n\t\t\t// for a different purpose than \"position=\"\n\t\t\t// all regions here are shown in one view and scroll together, as in gmmode. it does not introduce subpanels\n\t\t\trglst = []\n\t\t\tfor (const s of urlp.get('regions').split(',')) {\n\t\t\t\tconst l = s.split(/[:-]/)\n\t\t\t\tconst chr = l[0]\n\t\t\t\tconst start = Number.parseInt(l[1])\n\t\t\t\tconst stop = Number.parseInt(l[2])\n\t\t\t\tif (Number.isNaN(start) || Number.isNaN(stop)) throw 'Invalid start/stop value in regions'\n\t\t\t\trglst.push({ chr: l[0], start: start, stop: stop })\n\t\t\t}\n\t\t}\n\n\t\tif (!position && !rglst) {\n\t\t\t// no position given, use default\n\t\t\tif (genomeobj.defaultcoord) {\n\t\t\t\tposition = {\n\t\t\t\t\tchr: genomeobj.defaultcoord.chr,\n\t\t\t\t\tstart: genomeobj.defaultcoord.start,\n\t\t\t\t\tstop: genomeobj.defaultcoord.stop\n\t\t\t\t}\n\t\t\t}\n\t\t}\n\n\t\tif (position) {\n\t\t\tpar.chr = position.chr\n\t\t\tpar.start = position.start\n\t\t\tpar.stop = position.stop\n\t\t} else if (rglst) {\n\t\t\tpar.rglst = rglst\n\t\t}\n\n\t\tif (urlp.has('hlregion')) {\n\t\t\tconst lst = []\n\t\t\tfor (const t of urlp.get('hlregion').split(',')) {\n\t\t\t\tconst pos = string2pos(t, genomeobj, true)\n\t\t\t\tif (pos) lst.push(pos)\n\t\t\t}\n\t\t\tif (lst.length) par.hlregions = lst\n\t\t}\n\n\t\tpar.datasetqueries = may_get_officialmds(urlp)\n\n\t\tpar.tklst = await get_tklst(urlp, genomeobj)\n\n\t\tfirst_genetrack_tolist(arg.genomes[genomename], par.tklst)\n\n\t\tmayAddBedjfilterbyname(urlp, par.tklst)\n\t\tconst b = await import('./block')\n\t\tnew b.Block(par)\n\t\treturn\n\t}\n\n\tif (urlp.has('gene')) {\n\t\tconst str = urlp.get('gene')\n\t\tif (str.length == 0) throw 'zero length query string'\n\t\tconst par = {\n\t\t\thostURL: arg.hostURL,\n\t\t\tquery: str,\n\t\t\tholder: arg.holder,\n\t\t\tvariantPageCall_snv: arg.variantPageCall_snv,\n\t\t\tsamplecart: arg.samplecart,\n\t\t\tdebugmode: arg.debugmode\n\t\t}\n\t\t{\n\t\t\tlet genomename\n\t\t\tfor (let n in arg.genomes) {\n\t\t\t\tif (arg.genomes[n].isdefault) {\n\t\t\t\t\tgenomename = n\n\t\t\t\t\tbreak\n\t\t\t\t}\n\t\t\t}\n\t\t\tif (urlp.has('genome')) {\n\t\t\t\tgenomename = urlp.get('genome')\n\t\t\t}\n\t\t\tif (!genomename) throw 'No genome, and none set as default'\n\t\t\tpar.genome = arg.genomes[genomename]\n\t\t\tif (!par.genome) throw 'invalid genome: ' + genomename\n\t\t}\n\t\tlet ds = null\n\t\tif (urlp.has('dataset')) {\n\t\t\tpar.dataset = urlp.get('dataset').split(',')\n\t\t}\n\t\tif (urlp.has('hlaachange')) {\n\t\t\tpar.hlaachange = new Map()\n\t\t\tfor (const s of urlp.get('hlaachange').split(',')) {\n\t\t\t\tpar.hlaachange.set(s, false)\n\t\t\t}\n\t\t}\n\t\tif (urlp.has('hlregion')) {\n\t\t\tconst lst = []\n\t\t\tfor (const t of urlp.get('hlregion').split(',')) {\n\t\t\t\tconst pos = string2pos(t, par.genome, true)\n\t\t\t\tif (pos) lst.push(pos)\n\t\t\t}\n\t\t\tif (lst.length) par.hlregions = lst\n\t\t}\n\n\t\tpar.tklst = await get_tklst(urlp, par.genome)\n\n\t\tmayAddBedjfilterbyname(urlp, par.tklst)\n\n\t\tpar.datasetqueries = may_get_officialmds(urlp)\n\t\tawait blockinit(par)\n\t\treturn\n\t}\n\n\tif (urlp.has('disco')) {\n\t\t// a direct link to make manual testing easy\n\t\tconst genomeName = urlp.get('genome')\n\t\tconst genome = arg.genomes[genomeName]\n\t\tif (!genome) throw 'genome missing'\n\t\tconst dslabel = urlp.get('dslabel')\n\t\tif (!dslabel) throw 'dslabel missing'\n\t\tconst sample_id = urlp.get('sample')\n\t\tif (!sample_id) throw 'sample_id missing'\n\t\tconst vocabApi = (await import('#termdb/vocabulary')).vocabInit({ state: { genome: genomeName, dslabel } })\n\t\tconst termdbConfig = await vocabApi.getTermdbConfig()\n\t\tawait (await import('#plots/plot.disco.js')).default(termdbConfig, dslabel, { sample_id }, arg.holder, genome)\n\t\treturn\n\t}\n\n\t///////////// legacy, totally replaced by mass. kept for some views on vizcom\n\tif (urlp.has('study')) {\n\t\tconst v = urlp.get('study')\n\t\tif (v != '') {\n\t\t\tloadstudycohort(\n\t\t\t\targ.genomes,\n\t\t\t\tv,\n\t\t\t\targ.holder,\n\t\t\t\targ.hostURL,\n\t\t\t\tundefined, // jwt\n\t\t\t\tfalse, // no show\n\t\t\t\targ.app || {\n\t\t\t\t\tdebugmode: arg.debugmode,\n\t\t\t\t\tinstanceTracker: arg.instanceTracker || {},\n\t\t\t\t\tcallbacks: arg.callbacks || {}\n\t\t\t\t}\n\t\t\t)\n\t\t}\n\t}\n}\n\nfunction may_get_officialmds(urlp) {\n\tif (!urlp.has('mds')) return\n\tconst tmp = urlp.get('mds').split(',')\n\tif (tmp[0] && tmp[1]) {\n\t\tconst dataset = { dataset: tmp[0], querykey: tmp[1] }\n\t\tif (urlp.has('sample')) {\n\t\t\tdataset.singlesample = { name: urlp.get('sample') }\n\t\t\t// quick fix!!\n\t\t\t// tell  mds_load_query_bykey to load assay tracks in this context, but will not do so if launching sample view from main tk\n\t\t\tdataset.getsampletrackquickfix = true\n\t\t}\n\t\treturn [dataset]\n\t}\n\treturn\n}\n\nexport async function get_tklst(urlp, genomeobj) {\n\tconst tklst = []\n\n\tfor (const [key, value] of urlp) {\n\t\tconst tks = await mayGetTkobj(key, value, urlp, genomeobj)\n\t\tif (!tks) continue // no tkobj derived, parameter doesn't match with anything\n\t\tif (Array.isArray(tks)) tklst.push(...tks)\n\t\telse tklst.push(tks)\n\t}\n\n\tfor (const t of tklst) {\n\t\t// uncertain reason why all tk are labeled as custom\n\t\t// the mds3 tk has \"dslabel\" and should be official, do not label as custom, so in block.tk.menu won't show the delete button\n\t\tif (t.type == 'mds3' && t.dslabel) continue\n\t\tt.iscustom = true\n\t}\n\n\t// quick fix to modify behaviors of mds tracks collected through parameters\n\t// if isdense=1, turn to dense\n\t// if sample=..., change to a single sample track\n\tif (urlp.has('isdense')) {\n\t\ttklst\n\t\t\t.filter(t => t.type == client.tkt.mdssvcnv)\n\t\t\t.forEach(t => {\n\t\t\t\tt.isdense = true\n\t\t\t\tt.isfull = false\n\t\t\t})\n\t}\n\tif (urlp.has('sample')) {\n\t\ttklst\n\t\t\t.filter(t => t.type == client.tkt.mdssvcnv)\n\t\t\t.forEach(t => {\n\t\t\t\tt.singlesample = { name: urlp.get('sample') }\n\t\t\t\tt.getsampletrackquickfix = true\n\t\t\t\t// XXX this doesn't work to load assay tracks for a custom mds, can only load for official mds\n\t\t\t\t// for both custom and official, the expression rank track is not loaded.\n\t\t\t})\n\t}\n\treturn tklst\n}\n\n/*\nreturns:\n- object for one successfully parsed track\n- array for multiple track objects, could be empty!\n- null for no tracks\n*/\nexport async function mayGetTkobj(key, value, urlp, genomeobj) {\n\tif (key == 'mds3') {\n\t\t// official mds3 dataset; value is comma-joined dslabels\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (const n of lst) {\n\t\t\tconst tk = {\n\t\t\t\ttype: client.tkt.mds3,\n\t\t\t\tdslabel: n\n\t\t\t}\n\t\t\tif (urlp.has('token')) tk.token = urlp.get('token') // temporary\n\t\t\tif (urlp.has('filterobj')) tk.filterObj = urlp.get('filterobj')\n\t\t\tif (urlp.has('cnvonly')) tk.hardcodeCnvOnly = true // quick fix for testing cnv-only mode via url param; in actual use this flag should be set in runpp()\n\t\t\ttks.push(tk)\n\t\t}\n\t\treturn tks\n\t}\n\n\tif (key == 'mds3bcffile') {\n\t\t// \"name,path\" pairs to server-side vcf files\n\t\tconst [tkname, bcffile] = value.split(',')\n\t\tlet tk\n\t\tif (tkname && bcffile) {\n\t\t\ttk = {\n\t\t\t\ttype: client.tkt.mds3,\n\t\t\t\tname: tkname,\n\t\t\t\tbcf: { file: bcffile }\n\t\t\t}\n\t\t}\n\t\treturn tk\n\t}\n\tif (key == 'mds3bcfurl') {\n\t\t// \"name,url,indexURL\" to remote file. indexURL is optional when the index file is not co-locating with the bcf file\n\t\tconst [tkname, url, indexURL] = value.split(',')\n\t\tlet tk\n\t\tif (tkname && url) {\n\t\t\ttk = {\n\t\t\t\ttype: client.tkt.mds3,\n\t\t\t\tname: tkname,\n\t\t\t\tbcf: { url, indexURL }\n\t\t\t}\n\t\t}\n\t\treturn tk\n\t}\n\n\tif (key == 'arcfile') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: client.tkt.hicstraw,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\tbedfile: lst[i + 1],\n\t\t\t\t\tmode_hm: false,\n\t\t\t\t\tmode_arc: true\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\n\tif (key == 'mdsjson' || key == 'mdsjsonurl') {\n\t\tlet url_str, file_str\n\t\tif (key == 'mdsjson') file_str = value\n\t\telse url_str = value\n\t\treturn await mdsjson.init_mdsjson(file_str, url_str)\n\t}\n\n\tif (key == 'tkjsonfile') {\n\t\tconst re = await client.dofetch('textfile', { file: value })\n\t\tif (re.error) throw re.error\n\t\tif (!re.text) throw '.text missing'\n\t\tconst lst = JSON.parse(re.text)\n\t\tconst tks = []\n\t\tfor (const i of lst) {\n\t\t\tif (i.isfacet) {\n\t\t\t\tif (!genomeobj.tkset) genomeobj.tkset = []\n\t\t\t\tif (!i.tracks) throw '.tracks[] missing from a facet table'\n\t\t\t\tif (!Array.isArray(i.tracks)) throw '.tracks[] not an array from a facet table'\n\t\t\t\ti.tklst = i.tracks\n\t\t\t\tdelete i.tracks\n\t\t\t\tfor (const t of i.tklst) {\n\t\t\t\t\tif (!t.assay) throw '.assay missing from a facet track'\n\t\t\t\t\tif (!t.sample) throw '.sample missing from a facet track'\n\t\t\t\t\t// must assign tkid otherwise the tk buttons from facet table won't work\n\t\t\t\t\tt.tkid = Math.random().toString()\n\t\t\t\t}\n\t\t\t\tgenomeobj.tkset.push(i)\n\t\t\t} else {\n\t\t\t\t// must be a track\n\t\t\t\ttks.push(i)\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\n\tif (key == 'bamfile') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: client.tkt.bam,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\tfile: lst[i + 1]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'bamurl') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: client.tkt.bam,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\turl: lst[i + 1]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'bedjfile') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: client.tkt.bedj,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\tfile: lst[i + 1]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'bedjurl') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: client.tkt.bedj,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\turl: lst[i + 1]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'hictkfile' || key == 'hictkurl') {\n\t\t// name,enzyme,file/url\n\t\tconst isfile = key == 'hictkfile'\n\t\tconst lst = value.split(',')\n\t\tconst norm = urlp.has('hictknorm') ? urlp.get('hictknorm').split(',') : null\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 3) {\n\t\t\tif (lst[i] && lst[i + 1] && lst[i + 2]) {\n\t\t\t\tconst t = {\n\t\t\t\t\ttype: client.tkt.hicstraw,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\tenzyme: lst[i + 1],\n\t\t\t\t\tnormalizationmethod: norm ? norm[i / 3] : null\n\t\t\t\t}\n\t\t\t\tif (isfile) {\n\t\t\t\t\tt.file = lst[i + 2]\n\t\t\t\t} else {\n\t\t\t\t\tt.url = lst[i + 2]\n\t\t\t\t}\n\t\t\t\ttks.push(t)\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'ldfile') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: client.tkt.ld,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\tfile: lst[i + 1]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'bigwigfile') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: client.tkt.bigwig,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\tfile: lst[i + 1],\n\t\t\t\t\tscale: { auto: 1 }\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'bigwigurl') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: client.tkt.bigwig,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\turl: lst[i + 1],\n\t\t\t\t\tscale: { auto: 1 }\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'junctionfile') {\n\t\t// legacy\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: client.tkt.junction,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\ttracks: [\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\tfile: lst[i + 1]\n\t\t\t\t\t\t}\n\t\t\t\t\t]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'junctionurl') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: client.tkt.junction,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\ttracks: [\n\t\t\t\t\t\t{\n\t\t\t\t\t\t\turl: lst[i + 1]\n\t\t\t\t\t\t}\n\t\t\t\t\t]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\t/*\n\tif (urlp.has('vcffile')) {\n\t\tconst lst = urlp.get('vcffile').split(',')\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttklst.push({\n\t\t\t\t\ttype: 'vcf',\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\tfile: lst[i + 1]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t}\n\tif (urlp.has('vcfurl')) {\n\t\tconst lst = urlp.get('vcfurl').split(',')\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttklst.push({\n\t\t\t\t\ttype: 'vcf',\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\turl: lst[i + 1]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t}\n\t*/\n\tif (key == 'aicheckfile') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: 'aicheck',\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\tfile: lst[i + 1]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'bampilefile') {\n\t\tconst lst = value.split(',')\n\t\tlet links = null\n\t\tif (urlp.has('bampilelink')) {\n\t\t\tlinks = urlp.get('bampilelink').split(',').map(decodeURIComponent)\n\t\t}\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\tconst tk = {\n\t\t\t\t\ttype: client.tkt.bampile,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\tfile: lst[i + 1]\n\t\t\t\t}\n\t\t\t\tif (links && links[i / 2]) {\n\t\t\t\t\ttk.link = links[i / 2]\n\t\t\t\t}\n\t\t\t\ttks.push(tk)\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'svcnvfpkmurl') {\n\t\tconst lst = value.split(',')\n\t\t// defines a single track, all members using url\n\t\tconst name = lst[0]\n\t\tconst type2url = {}\n\t\tfor (let i = 1; i < lst.length; i += 2) {\n\t\t\ttype2url[lst[i]] = lst[i + 1]\n\t\t}\n\t\tlet tk\n\t\tif (type2url.svcnv || type2url.vcf) {\n\t\t\ttk = {\n\t\t\t\ttype: client.tkt.mdssvcnv,\n\t\t\t\tname: name\n\t\t\t}\n\t\t\tif (type2url.svcnv) {\n\t\t\t\ttk.url = type2url.svcnv\n\t\t\t}\n\t\t\tif (type2url.vcf) {\n\t\t\t\ttk.checkvcf = {\n\t\t\t\t\turl: type2url.vcf,\n\t\t\t\t\tindexURL: type2url.vcfindex\n\t\t\t\t}\n\t\t\t}\n\t\t\tif (type2url.fpkm) {\n\t\t\t\ttk.checkexpressionrank = {\n\t\t\t\t\tdatatype: 'FPKM',\n\t\t\t\t\turl: type2url.fpkm,\n\t\t\t\t\tindexURL: type2url.fpkmindex\n\t\t\t\t}\n\t\t\t}\n\t\t}\n\t\treturn tk\n\t}\n\tif (key == 'svcnvfpkmfile') {\n\t\tconst lst = value.split(',')\n\t\t// defines a single track, all members using file\n\t\tconst name = lst[0]\n\t\tconst type2file = {}\n\t\tfor (let i = 1; i < lst.length; i += 2) {\n\t\t\ttype2file[lst[i]] = lst[i + 1]\n\t\t}\n\t\tlet tk\n\t\tif (type2file.svcnv || type2file.vcf) {\n\t\t\ttk = {\n\t\t\t\ttype: client.tkt.mdssvcnv,\n\t\t\t\tname: name\n\t\t\t}\n\t\t\tif (type2file.svcnv) {\n\t\t\t\ttk.file = type2file.svcnv\n\t\t\t}\n\t\t\tif (type2file.vcf) {\n\t\t\t\ttk.checkvcf = {\n\t\t\t\t\tfile: type2file.vcf\n\t\t\t\t}\n\t\t\t}\n\t\t\tif (type2file.fpkm) {\n\t\t\t\ttk.checkexpressionrank = {\n\t\t\t\t\tdatatype: 'FPKM',\n\t\t\t\t\tfile: type2file.fpkm\n\t\t\t\t}\n\t\t\t}\n\t\t}\n\t\treturn tk\n\t}\n\tif (key == 'mdsjunctionfile') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: 'mdsjunction',\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\tfile: lst[i + 1]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\tif (key == 'junctionmatrix') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: 'mdsjunction',\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\tfile2: lst[i + 1] // quick fix to support new file type\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n\n\tif (key == 'junctionrnapeg') {\n\t\tconst lst = value.split(',')\n\t\tconst tks = []\n\t\tfor (let i = 0; i < lst.length; i += 2) {\n\t\t\tif (lst[i] && lst[i + 1]) {\n\t\t\t\ttks.push({\n\t\t\t\t\ttype: client.tkt.junction,\n\t\t\t\t\tname: lst[i],\n\t\t\t\t\ttracks: [{ rnapegfile: lst[i + 1] }]\n\t\t\t\t})\n\t\t\t}\n\t\t}\n\t\treturn tks\n\t}\n}\n\nfunction mayAddBedjfilterbyname(urlp, tklst) {\n\t/* !! a quick fix !!\n\tthe filter string will be applied to all bedj tracks,\n\trather than specific for a track\n\tmay mess up with other bedj tracks shown at the same time\n\t*/\n\tif (urlp.has('bedjfilterbyname')) {\n\t\tfor (const t of tklst) {\n\t\t\tif (t.type == 'bedj') t.filterByName = urlp.get('bedjfilterbyname')\n\t\t}\n\t}\n}\n"],
+  "mappings": 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+  "names": ["element"]
+}

package/dist/chunk-IP4T477W.js

@@ -0,0 +1,92 @@
+import {
+  getPlotConfig
+} from "./chunk-GTOY3JJO.js";
+import {
+  fillTermWrapper
+} from "./chunk-7FEHI46K.js";
+import {
+  copyMerge
+} from "./chunk-MVTCBVSX.js";
+import {
+  TermTypes,
+  numericTypes
+} from "./chunk-MDL2HG3N.js";
+
+// plots/matrix/hierCluster.config.js
+async function getPlotConfig2(opts = {}, app) {
+  opts.chartType = "hierCluster";
+  const config = await getPlotConfig(opts, app);
+  delete config.genes;
+  config.settings.hierCluster = {
+    /* type of data used for clustering
+    exciting todo: (to introduce new dt values)
+    - gene dependency
+    - numeric dic term
+    - non-gene genomic stuff that resolves into numeric quantities (cpg meth)
+    - metabolite
+    */
+    dataType: config.dataType,
+    // adjust the default group name based on automatically detected term types
+    // Done in matrix.cells.js: setHierClusterCellProps
+    // termGroupName: 'Expression',
+    clusterSamples: true,
+    clusterRows: true,
+    clusterMethod: "average",
+    // complete
+    distanceMethod: "euclidean",
+    zScoreCap: 5,
+    zScoreTransformation: true,
+    xDendrogramHeight: 100,
+    yDendrogramHeight: 200,
+    colorScale: "blueWhiteRed"
+  };
+  const overrides = app.vocabApi.termdbConfig.hierCluster || {};
+  const hierClusterSubTypeOverrides = app.vocabApi.termdbConfig[`${config.dataType}Cluster`] || {};
+  copyMerge(
+    config.settings.hierCluster,
+    overrides.settings,
+    opts.settings?.hierCluster || {},
+    hierClusterSubTypeOverrides.settings
+  );
+  {
+    const c = config.settings.hierCluster.colorScale;
+    if (!c) throw "colorScale missing";
+  }
+  config.settings.matrix.collabelpos = "top";
+  const termGroupName = config.settings.hierCluster.termGroupName;
+  const hcTermGroup = config.termgroups.find((g) => g.type == "hierCluster" || g.name == termGroupName) || {
+    name: termGroupName
+  };
+  hcTermGroup.type = "hierCluster";
+  if (!hcTermGroup.lst?.length) {
+    if (!Array.isArray(opts.terms)) throw "opts.terms[] not array (may show geneset edit ui)";
+    const promises = [];
+    for (const i of opts.terms) {
+      const tw = i.term ? i : { term: i };
+      if (!tw.term.type) {
+        if (config.dataType == TermTypes.GENE_EXPRESSION || config.dataType == TermTypes.METABOLITE_INTENSITY || config.dataType == TermTypes.PROTEOME_ABUNDANCE) {
+          tw.term.type = config.dataType;
+        } else {
+          throw `term type missing and cannot be assigned by dataType`;
+        }
+      } else if (!numericTypes.has(tw.term.type)) {
+        throw "term type is not numeric";
+      } else if (config.dataType && !canTermBeInHierGrp(config.dataType, tw.term.type)) {
+        throw `cannot have term type ${tw.term.type} in ${config.dataType} term group`;
+      }
+      promises.push(fillTermWrapper(tw, app.vocabApi));
+    }
+    hcTermGroup.lst = await Promise.all(promises);
+    if (config.termgroups.indexOf(hcTermGroup) == -1) config.termgroups.unshift(hcTermGroup);
+  }
+  config.settings.matrix.maxSample = 1e5;
+  return config;
+}
+function canTermBeInHierGrp(grpType, twType) {
+  return twType == grpType;
+}
+
+export {
+  getPlotConfig2 as getPlotConfig
+};
+//# sourceMappingURL=chunk-IP4T477W.js.map

package/dist/chunk-IQIXGTQV.js

@@ -0,0 +1,84 @@
+// ../shared/utils/src/tree.js
+var hardcode_root = "root";
+var hierarchy_spacer = "...";
+function stratinput(lst, levels) {
+  const lp = /* @__PURE__ */ Object.create(null);
+  const nodes = /* @__PURE__ */ Object.create(null);
+  const size = /* @__PURE__ */ Object.create(null);
+  for (const m of lst) {
+    for (const [i, lev] of levels.entries()) {
+      const thisv = getkey(m, i, levels);
+      const pav = getkey(m, i - 1, levels);
+      if (!m[lev.k]) {
+        if (i > 0) {
+          size[pav] += 1;
+        }
+        break;
+      }
+      lp[thisv] = pav;
+      if (!(thisv in size)) {
+        size[thisv] = 0;
+      }
+      if (!(thisv in nodes)) {
+        const n = {
+          lst: []
+        };
+        if (lev.full) {
+          n.full = m[lev.full];
+        }
+        n.id0 = levels[0].k;
+        n.v0 = m[levels[0].k];
+        if (i == 1) {
+          n.id1 = levels[1].k;
+          n.v1 = m[levels[1].k];
+        }
+        if (i == 2) {
+          n.id2 = levels[2].k;
+          n.v1 = m[levels[2].k];
+        }
+        nodes[thisv] = n;
+      }
+      nodes[thisv].lst.push(m);
+      if (i == levels.length - 1) {
+        size[thisv] += 1;
+      }
+    }
+  }
+  const nlst = [{ id: hardcode_root, name: hardcode_root }];
+  for (const chid in lp) {
+    const paid = lp[chid];
+    const n = nodes[chid];
+    const fields = chid.split(hierarchy_spacer);
+    nlst.push({
+      id: chid,
+      parentId: paid,
+      lst: n.lst,
+      value: size[chid],
+      name: fields[fields.length - 1],
+      // show this instead of chid
+      full: n.full,
+      id0: n.id0,
+      v0: n.v0,
+      id1: n.id1,
+      v1: n.v1,
+      id2: n.id2,
+      v2: n.v2
+    });
+  }
+  return nlst;
+}
+function getkey(m, i, levels) {
+  const klst = [hardcode_root];
+  for (let j = 0; j < i; j++) {
+    klst.push(m[levels[j].k]);
+  }
+  if (i >= 0) {
+    klst.push(m[levels[i].k]);
+  }
+  return klst.join(hierarchy_spacer);
+}
+
+export {
+  stratinput
+};
+//# sourceMappingURL=chunk-IQIXGTQV.js.map

package/dist/chunk-IQIXGTQV.js.map

@@ -0,0 +1,7 @@
+{
+  "version": 3,
+  "sources": ["../../shared/utils/src/tree.js"],
+  "sourcesContent": ["/*\ninput:\n1. list of leaf nodes, e.g. mutation cases, each with a set of key-value pairs\n2. levels of hierarchy in an ordered list\n   each item: { k, full }\n   \"k\" and \"full\" are two attribute keys\n\noutput:\na list of items, as input for d3-hierarchy.stratify\none item for each child-parent relationship in the hierarchy\n{\n\tid:\n\tparentId:\n\tlst:\n\tvalue:\n\tname:\n\tfull:\n\tid0:\n\tv0:\n\tid1:\n\tv1:\n\tid2:\n\tv2:\n}\n\nstrange issue: https://github.com/stjude/proteinpaint/commit/c36004d47d4374d2ade719c6ef9e2b848f0850dc\nusing Map for lp, nodes etc will cause memory issue, thus the use of simple objects\n\nto-do: verify this works after a reorg\n*/\n\nconst hardcode_root = 'root'\nconst hierarchy_spacer = '...'\n\nexport function stratinput(lst, levels) {\n\tconst lp = Object.create(null)\n\t// leaf to parent\n\t// k: HM...BALL...sub\n\t// v: HM...BALL\n\n\tconst nodes = Object.create(null)\n\t/*\n\tk: string id of node, e.g. HM...BALL\n\tv: node\n\t\t.full\n\t\t.lst[]\n\t\t\titems from input\n\t*/\n\n\tconst size = Object.create(null)\n\t// only increment size to leaf nodes, so that root.sum() will work\n\t// k: string id of a node, e.g. HM...BALL\n\t// v: number of items\n\n\tfor (const m of lst) {\n\t\tfor (const [i, lev] of levels.entries()) {\n\t\t\tconst thisv = getkey(m, i, levels)\n\t\t\tconst pav = getkey(m, i - 1, levels)\n\n\t\t\t// as mutations can come as {\"subtype\":\"\"}\n\t\t\t// in the sunburst chart at the subtype level, this mutation should not be counted\n\t\t\t// thus the test with !m[lev.k] rather than !(lev.k in m)\n\t\t\tif (!m[lev.k]) {\n\t\t\t\t// stop at this level\n\t\t\t\t// add count to prev level\n\t\t\t\tif (i > 0) {\n\t\t\t\t\tsize[pav] += 1\n\t\t\t\t}\n\t\t\t\tbreak\n\t\t\t}\n\n\t\t\tlp[thisv] = pav\n\t\t\tif (!(thisv in size)) {\n\t\t\t\tsize[thisv] = 0\n\t\t\t}\n\t\t\tif (!(thisv in nodes)) {\n\t\t\t\tconst n = {\n\t\t\t\t\tlst: []\n\t\t\t\t}\n\t\t\t\tif (lev.full) {\n\t\t\t\t\tn.full = m[lev.full]\n\t\t\t\t}\n\n\t\t\t\tn.id0 = levels[0].k\n\t\t\t\tn.v0 = m[levels[0].k]\n\t\t\t\tif (i == 1) {\n\t\t\t\t\tn.id1 = levels[1].k\n\t\t\t\t\tn.v1 = m[levels[1].k]\n\t\t\t\t}\n\t\t\t\tif (i == 2) {\n\t\t\t\t\tn.id2 = levels[2].k\n\t\t\t\t\tn.v1 = m[levels[2].k]\n\t\t\t\t}\n\n\t\t\t\tnodes[thisv] = n\n\t\t\t}\n\t\t\tnodes[thisv].lst.push(m)\n\t\t\tif (i == levels.length - 1) {\n\t\t\t\tsize[thisv] += 1\n\t\t\t}\n\t\t}\n\t}\n\n\tconst nlst = [{ id: hardcode_root, name: hardcode_root }]\n\n\tfor (const chid in lp) {\n\t\tconst paid = lp[chid]\n\t\tconst n = nodes[chid]\n\t\tconst fields = chid.split(hierarchy_spacer)\n\t\tnlst.push({\n\t\t\tid: chid,\n\t\t\tparentId: paid,\n\t\t\tlst: n.lst,\n\t\t\tvalue: size[chid],\n\t\t\tname: fields[fields.length - 1], // show this instead of chid\n\t\t\tfull: n.full,\n\t\t\tid0: n.id0,\n\t\t\tv0: n.v0,\n\t\t\tid1: n.id1,\n\t\t\tv1: n.v1,\n\t\t\tid2: n.id2,\n\t\t\tv2: n.v2\n\t\t})\n\t}\n\treturn nlst\n}\n\nfunction getkey(m, i, levels) {\n\t// if i is 0, return 'root'\n\tconst klst = [hardcode_root]\n\tfor (let j = 0; j < i; j++) {\n\t\tklst.push(m[levels[j].k])\n\t}\n\tif (i >= 0) {\n\t\tklst.push(m[levels[i].k])\n\t}\n\treturn klst.join(hierarchy_spacer)\n}\n"],
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+}

package/dist/chunk-IXT4U5CE.js

@@ -0,0 +1,91 @@
+import {
+  addGeneSearchbox,
+  isoformSelect,
+  sayerror
+} from "./chunk-7FEHI46K.js";
+import {
+  Menu
+} from "./chunk-2SRMRC6L.js";
+import {
+  dofetch3
+} from "./chunk-TCPU43TU.js";
+import {
+  ISOFORM_EXPRESSION
+} from "./chunk-MDL2HG3N.js";
+
+// termdb/handlers/isoformExpression.ts
+var SearchHandler = class {
+  constructor() {
+    this.currentGene = null;
+  }
+  init(opts) {
+    this.callback = opts.callback;
+    this.app = opts.app;
+    const holder = opts.holder.append("div").style("padding", "10px 0px");
+    this.dom = {
+      errDiv: holder.append("div").style("margin", "5px 0px").style("display", "none")
+    };
+    const geneSearch = addGeneSearchbox({
+      tip: new Menu({ padding: "0px" }),
+      genome: opts.genomeObj,
+      row: holder,
+      searchOnly: "gene",
+      callback: async () => {
+        try {
+          this.dom.errDiv.style("display", "none");
+          if (!geneSearch.geneSymbol) throw new Error("No gene selected");
+          if (geneSearch.geneSymbol === this.currentGene) return;
+          this.currentGene = geneSearch.geneSymbol;
+          if (this.dom.isoformDiv) this.dom.isoformDiv.remove();
+          this.dom.isoformDiv = holder.append("div");
+          await this.showIsoforms(geneSearch.geneSymbol, opts.genomeObj);
+        } catch (e) {
+          this.dom.errDiv.style("display", "block");
+          sayerror(this.dom.errDiv, "Error: " + (e instanceof Error ? e.message : String(e)));
+        }
+      }
+    });
+  }
+  async showIsoforms(gene, genomeObj) {
+    if (!gene) throw new Error("No gene selected");
+    const data = await dofetch3("genelookup", { body: { genome: genomeObj.name, input: gene, deep: 1 } });
+    if (!data.gmlst?.length) throw new Error(`No isoforms found for ${gene}`);
+    const enstCandidates = data.gmlst.filter((gm) => gm.isoform?.startsWith("ENST"));
+    if (enstCandidates.length === 0) throw new Error(`No Ensembl transcript isoforms found for ${gene}`);
+    const { available } = await dofetch3("termdb/isoformAvailability", {
+      body: {
+        genome: genomeObj.name,
+        dslabel: this.app.vocabApi.vocab.dslabel,
+        isoforms: enstCandidates.map((gm) => gm.isoform)
+      }
+    });
+    const availableSet = new Set(available || []);
+    const enstModels = enstCandidates.filter((gm) => availableSet.has(gm.isoform));
+    if (enstModels.length === 0) throw new Error(`No isoforms with data found for ${gene}`);
+    if (gene !== this.currentGene) return;
+    const div = this.dom.isoformDiv;
+    div.append("div").style("margin-bottom", "8px").style("opacity", 0.65).text(`${gene} \u2014 select an isoform:`);
+    isoformSelect({
+      holder: div,
+      allgm: enstModels,
+      onSelect: (gm) => {
+        this.selectIsoform(gm.isoform, gene);
+      }
+    });
+  }
+  selectIsoform(isoform, gene) {
+    const unit = this.app.vocabApi.termdbConfig.queries.isoformExpression?.unit || "Isoform Expression";
+    const name = `${isoform} ${unit}`;
+    this.callback({ isoform, gene, name, type: ISOFORM_EXPRESSION });
+  }
+};
+function filterIsoforms(gmlst, availableItems) {
+  const itemSet = new Set(availableItems);
+  return gmlst.filter((gm) => gm.isoform?.startsWith("ENST") && (itemSet.size === 0 || itemSet.has(gm.isoform)));
+}
+
+export {
+  SearchHandler,
+  filterIsoforms
+};
+//# sourceMappingURL=chunk-IXT4U5CE.js.map

package/dist/chunk-IXT4U5CE.js.map

@@ -0,0 +1,7 @@
+{
+  "version": 3,
+  "sources": ["../termdb/handlers/isoformExpression.ts"],
+  "sourcesContent": ["import { Menu, addGeneSearchbox, sayerror, isoformSelect } from '#dom'\nimport type { GeneModel, IsoformTerm } from '#dom/types/isoformSelect'\nimport type { Div } from '../../types/d3'\nimport { dofetch3 } from '#common/dofetch'\nimport { ISOFORM_EXPRESSION } from '#shared/terms.js'\n\nexport class SearchHandler {\n\tcallback!: (term: IsoformTerm) => void\n\tapp: any\n\tdom!: { errDiv: Div; isoformDiv?: Div }\n\tcurrentGene: string | null = null\n\n\tinit(opts) {\n\t\tthis.callback = opts.callback\n\t\tthis.app = opts.app\n\t\tconst holder = opts.holder.append('div').style('padding', '10px 0px')\n\t\tthis.dom = {\n\t\t\terrDiv: holder.append('div').style('margin', '5px 0px').style('display', 'none')\n\t\t}\n\n\t\tconst geneSearch = addGeneSearchbox({\n\t\t\ttip: new Menu({ padding: '0px' }),\n\t\t\tgenome: opts.genomeObj,\n\t\t\trow: holder,\n\t\t\tsearchOnly: 'gene',\n\t\t\tcallback: async () => {\n\t\t\t\ttry {\n\t\t\t\t\tthis.dom.errDiv.style('display', 'none')\n\t\t\t\t\tif (!geneSearch.geneSymbol) throw new Error('No gene selected')\n\t\t\t\t\t// guard against duplicate fires for the same gene\n\t\t\t\t\tif (geneSearch.geneSymbol === this.currentGene) return\n\t\t\t\t\tthis.currentGene = geneSearch.geneSymbol\n\t\t\t\t\t// isoformDiv is created after the search box so results appear below\n\t\t\t\t\tif (this.dom.isoformDiv) this.dom.isoformDiv.remove()\n\t\t\t\t\tthis.dom.isoformDiv = holder.append('div')\n\t\t\t\t\tawait this.showIsoforms(geneSearch.geneSymbol, opts.genomeObj)\n\t\t\t\t} catch (e: unknown) {\n\t\t\t\t\tthis.dom.errDiv.style('display', 'block')\n\t\t\t\t\tsayerror(this.dom.errDiv, 'Error: ' + (e instanceof Error ? e.message : String(e)))\n\t\t\t\t}\n\t\t\t}\n\t\t})\n\t}\n\n\tasync showIsoforms(gene: string, genomeObj: any) {\n\t\tif (!gene) throw new Error('No gene selected')\n\n\t\t// deep lookup to get all isoforms for this gene\n\t\tconst data = await dofetch3('genelookup', { body: { genome: genomeObj.name, input: gene, deep: 1 } })\n\t\tif (!data.gmlst?.length) throw new Error(`No isoforms found for ${gene}`)\n\n\t\t// filter to ENST isoforms, then check which have data via server-side lookup\n\t\tconst enstCandidates = data.gmlst.filter((gm: any) => gm.isoform?.startsWith('ENST'))\n\t\tif (enstCandidates.length === 0) throw new Error(`No Ensembl transcript isoforms found for ${gene}`)\n\n\t\tconst { available } = await dofetch3('termdb/isoformAvailability', {\n\t\t\tbody: {\n\t\t\t\tgenome: genomeObj.name,\n\t\t\t\tdslabel: this.app.vocabApi.vocab.dslabel,\n\t\t\t\tisoforms: enstCandidates.map((gm: any) => gm.isoform)\n\t\t\t}\n\t\t})\n\t\tconst availableSet = new Set(available || [])\n\t\tconst enstModels = enstCandidates.filter((gm: any) => availableSet.has(gm.isoform))\n\t\tif (enstModels.length === 0) throw new Error(`No isoforms with data found for ${gene}`)\n\n\t\t// bail if the user already searched a different gene while we were fetching\n\t\tif (gene !== this.currentGene) return\n\n\t\tconst div = this.dom.isoformDiv!\n\t\tdiv.append('div').style('margin-bottom', '8px').style('opacity', 0.65).text(`${gene} \u2014 select an isoform:`)\n\n\t\tisoformSelect({\n\t\t\tholder: div,\n\t\t\tallgm: enstModels,\n\t\t\tonSelect: (gm: GeneModel) => {\n\t\t\t\tthis.selectIsoform(gm.isoform, gene)\n\t\t\t}\n\t\t})\n\t}\n\n\tselectIsoform(isoform: string, gene: string) {\n\t\tconst unit = this.app.vocabApi.termdbConfig.queries.isoformExpression?.unit || 'Isoform Expression'\n\t\tconst name = `${isoform} ${unit}`\n\t\tthis.callback({ isoform, gene, name, type: ISOFORM_EXPRESSION })\n\t}\n}\n\n/** Filter gene models to ENST isoforms that exist in the available items list.\n *  If availableItems is empty, all ENST isoforms are returned (no filtering). */\nexport function filterIsoforms(gmlst: GeneModel[], availableItems: string[]) {\n\tconst itemSet = new Set(availableItems)\n\treturn gmlst.filter(gm => gm.isoform?.startsWith('ENST') && (itemSet.size === 0 || itemSet.has(gm.isoform)))\n}\n"],
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