@precisa-saude/fhir 0.8.0 → 0.10.0

package/dist/index.js

@@ -3,7 +3,7 @@ import {
   labReportToFHIR,
   labResultToFHIRBundle,
   userProfileToFHIR
-} from "./chunk-4KGWSF55.js";
+} from "./chunk-N6J26FVW.js";
 import {
   MAX_FILE_SIZE,
   MAX_OBSERVATIONS,
@@ -51,7 +51,7 @@ import {
   getFallbackReferenceRange,
   getRangeDirection,
   getReferenceRange
-} from "./chunk-YXYGKTVB.js";
+} from "./chunk-GTKRPCZB.js";
 import {
   BIOMARKER_DEFAULT_UNIT,
   BIOMARKER_UNITS,
@@ -61,7 +61,7 @@ import {
   getDefaultUnit,
   getSIUnit,
   unitToUCUM
-} from "./chunk-R25V2E6S.js";
+} from "./chunk-R4MUCMO3.js";
 import {
   validateFHIRDiagnosticReport,
   validateFHIRImportBundle,

package/dist/reference-ranges.cjs

@@ -5,8 +5,8 @@
 
 
 
-var _chunkLYDCZW4Ccjs = require('./chunk-LYDCZW4C.cjs');
-require('./chunk-ZYSD6A2K.cjs');
+var _chunkD6XKCRS2cjs = require('./chunk-D6XKCRS2.cjs');
+require('./chunk-MJ254F5K.cjs');
 
 
 
@@ -14,5 +14,5 @@ require('./chunk-ZYSD6A2K.cjs');
 
 
 
-exports.applyFallbackReferenceRanges = _chunkLYDCZW4Ccjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkLYDCZW4Ccjs.biomarkerRangeDefinitions; exports.defaultReferenceRanges = _chunkLYDCZW4Ccjs.defaultReferenceRanges; exports.getFallbackReferenceRange = _chunkLYDCZW4Ccjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkLYDCZW4Ccjs.getRangeDirection; exports.getReferenceRange = _chunkLYDCZW4Ccjs.getReferenceRange;
+exports.applyFallbackReferenceRanges = _chunkD6XKCRS2cjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkD6XKCRS2cjs.biomarkerRangeDefinitions; exports.defaultReferenceRanges = _chunkD6XKCRS2cjs.defaultReferenceRanges; exports.getFallbackReferenceRange = _chunkD6XKCRS2cjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkD6XKCRS2cjs.getRangeDirection; exports.getReferenceRange = _chunkD6XKCRS2cjs.getReferenceRange;
 //# sourceMappingURL=reference-ranges.cjs.map

package/dist/reference-ranges.js

@@ -5,8 +5,8 @@ import {
   getFallbackReferenceRange,
   getRangeDirection,
   getReferenceRange
-} from "./chunk-YXYGKTVB.js";
-import "./chunk-R25V2E6S.js";
+} from "./chunk-GTKRPCZB.js";
+import "./chunk-R4MUCMO3.js";
 export {
   applyFallbackReferenceRanges,
   biomarkerRangeDefinitions,

package/dist/units.cjs

@@ -7,7 +7,7 @@
 
 
 
-var _chunkZYSD6A2Kcjs = require('./chunk-ZYSD6A2K.cjs');
+var _chunkMJ254F5Kcjs = require('./chunk-MJ254F5K.cjs');
 
 
 
@@ -17,5 +17,5 @@ var _chunkZYSD6A2Kcjs = require('./chunk-ZYSD6A2K.cjs');
 
 
 
-exports.BIOMARKER_DEFAULT_UNIT = _chunkZYSD6A2Kcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_UNITS = _chunkZYSD6A2Kcjs.BIOMARKER_UNITS; exports.UNIT_TO_UCUM = _chunkZYSD6A2Kcjs.UNIT_TO_UCUM; exports.convertUnit = _chunkZYSD6A2Kcjs.convertUnit; exports.getCanonicalUnit = _chunkZYSD6A2Kcjs.getCanonicalUnit; exports.getDefaultUnit = _chunkZYSD6A2Kcjs.getDefaultUnit; exports.getSIUnit = _chunkZYSD6A2Kcjs.getSIUnit; exports.unitToUCUM = _chunkZYSD6A2Kcjs.unitToUCUM;
+exports.BIOMARKER_DEFAULT_UNIT = _chunkMJ254F5Kcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_UNITS = _chunkMJ254F5Kcjs.BIOMARKER_UNITS; exports.UNIT_TO_UCUM = _chunkMJ254F5Kcjs.UNIT_TO_UCUM; exports.convertUnit = _chunkMJ254F5Kcjs.convertUnit; exports.getCanonicalUnit = _chunkMJ254F5Kcjs.getCanonicalUnit; exports.getDefaultUnit = _chunkMJ254F5Kcjs.getDefaultUnit; exports.getSIUnit = _chunkMJ254F5Kcjs.getSIUnit; exports.unitToUCUM = _chunkMJ254F5Kcjs.unitToUCUM;
 //# sourceMappingURL=units.cjs.map

package/dist/units.js

@@ -7,7 +7,7 @@ import {
   getDefaultUnit,
   getSIUnit,
   unitToUCUM
-} from "./chunk-R25V2E6S.js";
+} from "./chunk-R4MUCMO3.js";
 export {
   BIOMARKER_DEFAULT_UNIT,
   BIOMARKER_UNITS,

package/package.json

@@ -1,6 +1,6 @@
 {
   "name": "@precisa-saude/fhir",
-  "version": "0.8.0",
+  "version": "0.10.0",
   "description": "Tipos FHIR R4, definições de biomarcadores, faixas de referência e conversores para o ecossistema de saúde brasileiro",
   "keywords": [
     "fhir",

package/dist/chunk-R25V2E6S.js

@@ -1,479 +0,0 @@
-// src/units.ts
-var UNIT_TO_UCUM = {
-  // Dimensionless / special measurements
-  "[pH]": "[pH]",
-  "{ratio}": "{ratio}",
-  "{specific gravity}": "{specific gravity}",
-  "/\xB5L": "/uL",
-  // Percentage
-  "%": "%",
-  // Count units
-  "10\xB3/\xB5L": "10*3/uL",
-  "10\u2076/\xB5L": "10*6/uL",
-  // Volume
-  fL: "fL",
-  g: "g",
-  // Mass concentration
-  "g/dL": "g/dL",
-  L: "L",
-  // Molar concentration
-  "mEq/L": "meq/L",
-  mg: "mg",
-  "mg/dL": "mg/dL",
-  mL: "mL",
-  "mmol/L": "mmol/L",
-  "mUI/mL": "m[IU]/mL",
-  ng: "ng",
-  "ng/dL": "ng/dL",
-  "ng/mL": "ng/mL",
-  "nmol/L": "nmol/L",
-  // Mass
-  pg: "pg",
-  "pg/mL": "pg/mL",
-  pH: "[pH]",
-  // Enzyme activity
-  "U/L": "U/L",
-  // Special units
-  "U/mL": "U/mL",
-  "UI/L": "[IU]/L",
-  "UI/mL": "[IU]/mL",
-  \u00B5g: "ug",
-  "\xB5g/dL": "ug/dL",
-  "\xB5mol/L": "umol/L",
-  "\xB5UI/mL": "u[IU]/mL"
-};
-var BIOMARKER_DEFAULT_UNIT = {
-  // Proteins
-  Albumin: "g/dL",
-  AlkalinePhosphatase: "U/L",
-  // Liver
-  ALT: "U/L",
-  AST: "U/L",
-  Calcium: "mg/dL",
-  Chloride: "mEq/L",
-  // Lipids
-  Cholesterol: "mg/dL",
-  // Kidney
-  Creatinine: "mg/dL",
-  eAG: "mg/dL",
-  Ferritin: "ng/mL",
-  FolicAcid: "ng/mL",
-  GGT: "U/L",
-  // Glucose/Diabetes
-  Glucose: "mg/dL",
-  HbA1c: "%",
-  Hct: "%",
-  HDL: "mg/dL",
-  // Hematology
-  Hgb: "g/dL",
-  Insulin: "\xB5UI/mL",
-  // Iron studies
-  Iron: "\xB5g/dL",
-  LDL: "mg/dL",
-  Magnesium: "mg/dL",
-  NonHDL_Cholesterol: "mg/dL",
-  // Urinalysis - dimensionless
-  pH_Urine: "[pH]",
-  Potassium: "mEq/L",
-  RDW: "%",
-  // Electrolytes
-  Sodium: "mEq/L",
-  SpecificGravity_Urine: "{specific gravity}",
-  T3Free: "pg/mL",
-  T4Free: "ng/dL",
-  TIBC: "\xB5g/dL",
-  TotalProtein: "g/dL",
-  TransferrinSaturation: "%",
-  Triglycerides: "mg/dL",
-  // Thyroid
-  TSH: "\xB5UI/mL",
-  Urea: "mg/dL",
-  UricAcid: "mg/dL",
-  // Vitamins
-  VitaminB12: "pg/mL",
-  VitaminD: "ng/mL",
-  VLDL: "mg/dL"
-};
-function unitToUCUM(unit) {
-  return UNIT_TO_UCUM[unit] || unit;
-}
-function getDefaultUnit(biomarkerCode) {
-  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || "";
-}
-var CBC_DIFF_ALIASES = {
-  "/ul": "/uL",
-  "/\xB5l": "/uL",
-  "10*3/ul": "K/uL",
-  "cells/ul": "/uL",
-  "cells/\xB5l": "/uL",
-  "k/ul": "K/uL",
-  "x10e3/ul": "K/uL"
-};
-var CBC_DIFF = {
-  canonicalUcum: "10*3/uL",
-  canonicalUnit: "K/uL",
-  siUcum: "10*3/uL",
-  siUnit: "K/uL"
-};
-var DEXA_KG_ALIASES = {
-  kg: "kg",
-  lb: "[lb_av]",
-  lbs: "[lb_av]"
-};
-var DEXA_KG = {
-  canonicalUcum: "kg",
-  canonicalUnit: "kg",
-  siUcum: "kg",
-  siUnit: "kg"
-};
-var URINE_SEDIMENT_ALIASES = {
-  "/hpf": "/HPF",
-  "/ml": "/mL"
-};
-var URINE_SEDIMENT = {
-  canonicalUcum: "/[HPF]",
-  canonicalUnit: "/HPF",
-  siUcum: "/[HPF]",
-  siUnit: "/HPF"
-};
-var BIOMARKER_UNITS = {
-  Albumin: {
-    aliases: { "g/dl": "g/dL", "g/l": "g/L" },
-    canonicalUcum: "g/dL",
-    canonicalUnit: "g/dL",
-    siUcum: "g/L",
-    siUnit: "g/L"
-  },
-  AntiThyroglobulin: {
-    aliases: { "iu/ml": "IU/mL", "ui/ml": "IU/mL" },
-    canonicalUcum: "[iU]/mL",
-    canonicalUnit: "IU/mL",
-    siUcum: "[iU]/mL",
-    siUnit: "IU/mL"
-  },
-  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
-  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
-  Cholesterol: {
-    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
-    canonicalUcum: "mg/dL",
-    canonicalUnit: "mg/dL",
-    molecularWeight: 386.65,
-    siUcum: "mmol/L",
-    siUnit: "mmol/L"
-  },
-  Creatinine: {
-    aliases: { "mg/dl": "mg/dL", "umol/l": "\xB5mol/L", "\xB5mol/l": "\xB5mol/L" },
-    canonicalUcum: "mg/dL",
-    canonicalUnit: "mg/dL",
-    molecularWeight: 113.12,
-    siUcum: "umol/L",
-    siUnit: "\xB5mol/L"
-  },
-  CRP: {
-    aliases: { "mg/dl": "mg/dL", "mg/l": "mg/L" },
-    canonicalUcum: "mg/L",
-    canonicalUnit: "mg/L",
-    siUcum: "mg/L",
-    siUnit: "mg/L"
-  },
-  eGFR: {
-    aliases: {
-      "ml/min/1,73 m2": "mL/min/1.73m\xB2",
-      "ml/min/1.73m2": "mL/min/1.73m\xB2",
-      "ml/min/1.73m\xB2": "mL/min/1.73m\xB2"
-    },
-    canonicalUcum: "mL/min/{1.73_m2}",
-    canonicalUnit: "mL/min/1.73m\xB2",
-    siUcum: "mL/min/{1.73_m2}",
-    siUnit: "mL/min/1.73m\xB2"
-  },
-  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
-  Estradiol: {
-    aliases: { "ng/dl": "ng/dL", "pg/ml": "pg/mL" },
-    canonicalUcum: "pg/mL",
-    canonicalUnit: "pg/mL",
-    molecularWeight: 272.38,
-    siUcum: "pmol/L",
-    siUnit: "pmol/L"
-  },
-  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
-  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
-  Ferritin: {
-    aliases: {
-      "mcg/l": "ng/mL",
-      "microg/l": "ng/mL",
-      "ng/ml": "ng/mL",
-      "\xB5g/l": "ng/mL"
-    },
-    canonicalUcum: "ng/mL",
-    canonicalUnit: "ng/mL",
-    siUcum: "ug/L",
-    siUnit: "\xB5g/L"
-  },
-  FSH: {
-    aliases: {
-      "iu/l": "mIU/mL",
-      "miu/ml": "mIU/mL",
-      "ui/l": "mIU/mL"
-    },
-    canonicalUcum: "mIU/mL",
-    canonicalUnit: "mIU/mL",
-    siUcum: "[iU]/L",
-    siUnit: "IU/L"
-  },
-  Glucose: {
-    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
-    canonicalUcum: "mg/dL",
-    canonicalUnit: "mg/dL",
-    molecularWeight: 180.156,
-    siUcum: "mmol/L",
-    siUnit: "mmol/L"
-  },
-  HDL: {
-    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
-    canonicalUcum: "mg/dL",
-    canonicalUnit: "mg/dL",
-    molecularWeight: 386.65,
-    siUcum: "mmol/L",
-    siUnit: "mmol/L"
-  },
-  Hgb: {
-    aliases: { "g/dl": "g/dL", "g/l": "g/L" },
-    canonicalUcum: "g/dL",
-    canonicalUnit: "g/dL",
-    siUcum: "g/L",
-    siUnit: "g/L"
-  },
-  Insulin: {
-    aliases: {
-      "mu/l": "uIU/mL",
-      "uiu/ml": "uIU/mL",
-      "\xB5u/ml": "uIU/mL",
-      "\xB5ui/ml": "uIU/mL"
-    },
-    canonicalUcum: "u[iU]/mL",
-    canonicalUnit: "uIU/mL",
-    siUcum: "pmol/L",
-    siUnit: "pmol/L"
-  },
-  Iron: {
-    aliases: {
-      "mcg/dl": "mcg/dL",
-      "microg/dl": "mcg/dL",
-      "ug/dl": "mcg/dL",
-      "\xB5g/dl": "mcg/dL"
-    },
-    canonicalUcum: "ug/dL",
-    canonicalUnit: "mcg/dL",
-    siUcum: "umol/L",
-    siUnit: "\xB5mol/L"
-  },
-  LDL: {
-    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
-    canonicalUcum: "mg/dL",
-    canonicalUnit: "mg/dL",
-    molecularWeight: 386.65,
-    siUcum: "mmol/L",
-    siUnit: "mmol/L"
-  },
-  LDL_Peak_Size: {
-    aliases: { \u00E5: "Ao", angstrom: "Ao", ao: "Ao", nm: "nm" },
-    canonicalUcum: "Ao",
-    canonicalUnit: "Angstrom",
-    siUcum: "nm",
-    siUnit: "nm"
-  },
-  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
-  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },
-  LH: {
-    aliases: {
-      "iu/l": "mIU/mL",
-      "miu/ml": "mIU/mL",
-      "ui/l": "mIU/mL"
-    },
-    canonicalUcum: "mIU/mL",
-    canonicalUnit: "mIU/mL",
-    siUcum: "[iU]/L",
-    siUnit: "IU/L"
-  },
-  Lipoprotein_a: {
-    aliases: { "mg/dl": "mg/dL", "nmol/l": "nmol/L" },
-    canonicalUcum: "nmol/L",
-    canonicalUnit: "nmol/L",
-    siUcum: "nmol/L",
-    siUnit: "nmol/L"
-  },
-  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
-  MCHC: {
-    aliases: { "g/dl": "g/dL", "g/l": "g/L" },
-    canonicalUcum: "g/dL",
-    canonicalUnit: "g/dL",
-    siUcum: "g/L",
-    siUnit: "g/L"
-  },
-  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
-  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
-  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
-  Prolactin: {
-    aliases: {
-      "microg/l": "ng/mL",
-      "ng/ml": "ng/mL",
-      "\xB5g/l": "ng/mL"
-    },
-    canonicalUcum: "ng/mL",
-    canonicalUnit: "ng/mL",
-    siUcum: "ug/L",
-    siUnit: "\xB5g/L"
-  },
-  RBC: {
-    aliases: {
-      "/ul": "/uL",
-      "/\xB5l": "/uL",
-      "10*6/ul": "M/uL",
-      "cells/ul": "/uL",
-      "m/ul": "M/uL",
-      "milh\xF5es/mm3": "M/uL",
-      "milh\xF5es/mm\xB3": "M/uL",
-      "x10e6/ul": "M/uL"
-    },
-    canonicalUcum: "10*6/uL",
-    canonicalUnit: "M/uL",
-    siUcum: "10*6/uL",
-    siUnit: "M/uL"
-  },
-  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },
-  TestosteroneFree: {
-    aliases: { "pg/ml": "pg/mL", "pmol/l": "pmol/L" },
-    canonicalUcum: "pg/mL",
-    canonicalUnit: "pg/mL",
-    molecularWeight: 288.42,
-    siUcum: "pmol/L",
-    siUnit: "pmol/L"
-  },
-  TIBC: {
-    aliases: {
-      "mcg/dl": "mcg/dL",
-      "microg/dl": "mcg/dL",
-      "ug/dl": "mcg/dL",
-      "\xB5g/dl": "mcg/dL"
-    },
-    canonicalUcum: "ug/dL",
-    canonicalUnit: "mcg/dL",
-    siUcum: "umol/L",
-    siUnit: "\xB5mol/L"
-  },
-  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
-  Triglycerides: {
-    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
-    canonicalUcum: "mg/dL",
-    canonicalUnit: "mg/dL",
-    molecularWeight: 885.4,
-    siUcum: "mmol/L",
-    siUnit: "mmol/L"
-  },
-  TSH: {
-    aliases: {
-      "miu/l": "uIU/mL",
-      "mui/l": "uIU/mL",
-      "uiu/ml": "uIU/mL",
-      "\xB5ui/ml": "uIU/mL"
-    },
-    canonicalUcum: "u[iU]/mL",
-    canonicalUnit: "uIU/mL",
-    siUcum: "mIU/L",
-    siUnit: "mIU/L"
-  },
-  Urea: {
-    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
-    canonicalUcum: "mg/dL",
-    canonicalUnit: "mg/dL",
-    molecularWeight: 60.06,
-    siUcum: "mmol/L",
-    siUnit: "mmol/L"
-  },
-  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
-  VATVolume: {
-    aliases: { cm3: "cm3", "cm\xB3": "cm3", in3: "[in_i]3", "in\xB3": "[in_i]3" },
-    canonicalUcum: "cm3",
-    canonicalUnit: "cm\xB3",
-    siUcum: "cm3",
-    siUnit: "cm\xB3"
-  },
-  VitaminB12: {
-    aliases: { "ng/l": "pg/mL", "pg/ml": "pg/mL" },
-    canonicalUcum: "pg/mL",
-    canonicalUnit: "pg/mL",
-    siUcum: "pmol/L",
-    siUnit: "pmol/L"
-  },
-  VitaminD: {
-    aliases: { "ng/ml": "ng/mL", "nmol/l": "nmol/L" },
-    canonicalUcum: "ng/mL",
-    canonicalUnit: "ng/mL",
-    molecularWeight: 384.64,
-    siUcum: "nmol/L",
-    siUnit: "nmol/L"
-  },
-  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF }
-};
-function getCanonicalUnit(code) {
-  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;
-}
-function getSIUnit(code) {
-  return BIOMARKER_UNITS[code]?.siUnit ?? null;
-}
-function normalizeUnit(unit, config) {
-  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;
-}
-var FIXED_FACTORS = {
-  "g/dL -> g/L": 10,
-  "g/L -> g/dL": 0.1,
-  "ng/dL -> pg/mL": 10,
-  "ng/mL -> \xB5g/L": 1,
-  "pg/mL -> ng/dL": 0.1,
-  "\xB5g/L -> ng/mL": 1
-};
-var MW_CONVERSIONS = {
-  "mg/dL -> mmol/L": { divideByMW: true, scale: 10 },
-  "mg/dL -> \xB5mol/L": { divideByMW: true, scale: 1e4 },
-  "mmol/L -> mg/dL": { divideByMW: false, scale: 10 },
-  "ng/dL -> nmol/L": { divideByMW: true, scale: 10 },
-  "ng/mL -> nmol/L": { divideByMW: true, scale: 1e3 },
-  "nmol/L -> ng/dL": { divideByMW: false, scale: 10 },
-  "nmol/L -> ng/mL": { divideByMW: false, scale: 1e3 },
-  "pg/mL -> pmol/L": { divideByMW: true, scale: 1e3 },
-  "pmol/L -> pg/mL": { divideByMW: false, scale: 1e3 },
-  "\xB5mol/L -> mg/dL": { divideByMW: false, scale: 1e4 }
-};
-function convertUnit(value, fromUnit, toUnit, biomarkerCode) {
-  const config = BIOMARKER_UNITS[biomarkerCode];
-  if (!config) return null;
-  const normFrom = normalizeUnit(fromUnit, config);
-  const normTo = normalizeUnit(toUnit, config);
-  if (normFrom === normTo) {
-    return { unit: normTo, value };
-  }
-  const key = `${normFrom} -> ${normTo}`;
-  const fixedFactor = FIXED_FACTORS[key];
-  if (fixedFactor !== void 0) {
-    return { unit: normTo, value: value * fixedFactor };
-  }
-  const mwConv = MW_CONVERSIONS[key];
-  if (mwConv && config.molecularWeight) {
-    const result = mwConv.divideByMW ? value * mwConv.scale / config.molecularWeight : value * config.molecularWeight / mwConv.scale;
-    return { unit: normTo, value: result };
-  }
-  return null;
-}
-
-export {
-  UNIT_TO_UCUM,
-  BIOMARKER_DEFAULT_UNIT,
-  unitToUCUM,
-  getDefaultUnit,
-  BIOMARKER_UNITS,
-  getCanonicalUnit,
-  getSIUnit,
-  convertUnit
-};
-//# sourceMappingURL=chunk-R25V2E6S.js.map

package/dist/chunk-R25V2E6S.js.map

@@ -1 +0,0 @@
-{"version":3,"sources":["../src/units.ts"],"sourcesContent":["/**\n * Unit Mappings and Biomarker Unit Definitions\n *\n * Maps units to UCUM format, provides default units for biomarkers,\n * and defines canonical/SI unit configurations with aliases.\n */\n\n// ─── UCUM Mappings ───────────────────────────────────────────────────────────\n\n/**\n * Map units to UCUM (Unified Code for Units of Measure)\n * See: https://ucum.org/\n */\nexport const UNIT_TO_UCUM: Record<string, string> = {\n  // Dimensionless / special measurements\n  '[pH]': '[pH]',\n  '{ratio}': '{ratio}',\n  '{specific gravity}': '{specific gravity}',\n\n  '/µL': '/uL',\n  // Percentage\n  '%': '%',\n  // Count units\n  '10³/µL': '10*3/uL',\n  '10⁶/µL': '10*6/uL',\n  // Volume\n  fL: 'fL',\n  g: 'g',\n\n  // Mass concentration\n  'g/dL': 'g/dL',\n  L: 'L',\n  // Molar concentration\n  'mEq/L': 'meq/L',\n\n  mg: 'mg',\n  'mg/dL': 'mg/dL',\n  mL: 'mL',\n  'mmol/L': 'mmol/L',\n  'mUI/mL': 'm[IU]/mL',\n\n  ng: 'ng',\n\n  'ng/dL': 'ng/dL',\n  'ng/mL': 'ng/mL',\n  'nmol/L': 'nmol/L',\n  // Mass\n  pg: 'pg',\n\n  'pg/mL': 'pg/mL',\n  pH: '[pH]',\n  // Enzyme activity\n  'U/L': 'U/L',\n  // Special units\n  'U/mL': 'U/mL',\n  'UI/L': '[IU]/L',\n\n  'UI/mL': '[IU]/mL',\n\n  µg: 'ug',\n  'µg/dL': 'ug/dL',\n  'µmol/L': 'umol/L',\n  'µUI/mL': 'u[IU]/mL',\n};\n\n/**\n * Default units for biomarkers when source data doesn't provide one\n * These are the most common units used in Brazilian labs\n */\nexport const BIOMARKER_DEFAULT_UNIT: Record<string, string> = {\n  // Proteins\n  Albumin: 'g/dL',\n  AlkalinePhosphatase: 'U/L',\n  // Liver\n  ALT: 'U/L',\n  AST: 'U/L',\n\n  Calcium: 'mg/dL',\n  Chloride: 'mEq/L',\n  // Lipids\n  Cholesterol: 'mg/dL',\n  // Kidney\n  Creatinine: 'mg/dL',\n  eAG: 'mg/dL',\n  Ferritin: 'ng/mL',\n\n  FolicAcid: 'ng/mL',\n  GGT: 'U/L',\n  // Glucose/Diabetes\n  Glucose: 'mg/dL',\n\n  HbA1c: '%',\n  Hct: '%',\n\n  HDL: 'mg/dL',\n  // Hematology\n  Hgb: 'g/dL',\n  Insulin: 'µUI/mL',\n\n  // Iron studies\n  Iron: 'µg/dL',\n  LDL: 'mg/dL',\n  Magnesium: 'mg/dL',\n  NonHDL_Cholesterol: 'mg/dL',\n\n  // Urinalysis - dimensionless\n  pH_Urine: '[pH]',\n  Potassium: 'mEq/L',\n  RDW: '%',\n  // Electrolytes\n  Sodium: 'mEq/L',\n  SpecificGravity_Urine: '{specific gravity}',\n\n  T3Free: 'pg/mL',\n  T4Free: 'ng/dL',\n  TIBC: 'µg/dL',\n  TotalProtein: 'g/dL',\n\n  TransferrinSaturation: '%',\n  Triglycerides: 'mg/dL',\n  // Thyroid\n  TSH: 'µUI/mL',\n\n  Urea: 'mg/dL',\n  UricAcid: 'mg/dL',\n\n  // Vitamins\n  VitaminB12: 'pg/mL',\n  VitaminD: 'ng/mL',\n  VLDL: 'mg/dL',\n};\n\n/**\n * Convert unit to UCUM format\n */\nexport function unitToUCUM(unit: string): string {\n  return UNIT_TO_UCUM[unit] || unit;\n}\n\n/**\n * Get default unit for a biomarker code\n * @param biomarkerCode - The biomarker code (e.g., \"Glucose\", \"HbA1c\")\n * @returns The default unit or empty string if not found\n */\nexport function getDefaultUnit(biomarkerCode: string): string {\n  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || '';\n}\n\n// ─── Biomarker Unit Configurations ───────────────────────────────────────────\n\n/** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */\n\nexport interface BiomarkerUnitConfig {\n  aliases: Record<string, string>;\n  canonicalUcum: string;\n  canonicalUnit: string;\n  molecularWeight?: number;\n  siUcum: string;\n  siUnit: string;\n}\n\nconst CBC_DIFF_ALIASES: Record<string, string> = {\n  '/ul': '/uL',\n  '/µl': '/uL',\n  '10*3/ul': 'K/uL',\n  'cells/ul': '/uL',\n  'cells/µl': '/uL',\n  'k/ul': 'K/uL',\n  'x10e3/ul': 'K/uL',\n};\nconst CBC_DIFF: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '10*3/uL',\n  canonicalUnit: 'K/uL',\n  siUcum: '10*3/uL',\n  siUnit: 'K/uL',\n};\nconst DEXA_KG_ALIASES: Record<string, string> = {\n  kg: 'kg',\n  lb: '[lb_av]',\n  lbs: '[lb_av]',\n};\nconst DEXA_KG: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'kg',\n  canonicalUnit: 'kg',\n  siUcum: 'kg',\n  siUnit: 'kg',\n};\n\n/**\n * Urine sediment units — Brazilian automated analyzers (Sysmex UF-series)\n * report in /mL while manual microscopy uses /HPF. Canonical unit is /HPF.\n */\nconst URINE_SEDIMENT_ALIASES: Record<string, string> = {\n  '/hpf': '/HPF',\n  '/ml': '/mL',\n};\nconst URINE_SEDIMENT: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '/[HPF]',\n  canonicalUnit: '/HPF',\n  siUcum: '/[HPF]',\n  siUnit: '/HPF',\n};\n\nexport const BIOMARKER_UNITS: Record<string, BiomarkerUnitConfig> = {\n  Albumin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  AntiThyroglobulin: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  Creatinine: {\n    aliases: { 'mg/dl': 'mg/dL', 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 113.12,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  CRP: {\n    aliases: { 'mg/dl': 'mg/dL', 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  eGFR: {\n    aliases: {\n      'ml/min/1,73 m2': 'mL/min/1.73m²',\n      'ml/min/1.73m2': 'mL/min/1.73m²',\n      'ml/min/1.73m²': 'mL/min/1.73m²',\n    },\n    canonicalUcum: 'mL/min/{1.73_m2}',\n    canonicalUnit: 'mL/min/1.73m²',\n    siUcum: 'mL/min/{1.73_m2}',\n    siUnit: 'mL/min/1.73m²',\n  },\n  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Estradiol: {\n    aliases: { 'ng/dl': 'ng/dL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 272.38,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Ferritin: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  FSH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Glucose: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 180.156,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  Hgb: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Insulin: {\n    aliases: {\n      'mu/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Iron: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  LDL_Peak_Size: {\n    aliases: { å: 'Ao', angstrom: 'Ao', ao: 'Ao', nm: 'nm' },\n    canonicalUcum: 'Ao',\n    canonicalUnit: 'Angstrom',\n    siUcum: 'nm',\n    siUnit: 'nm',\n  },\n  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  LH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Lipoprotein_a: {\n    aliases: { 'mg/dl': 'mg/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'nmol/L',\n    canonicalUnit: 'nmol/L',\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MCHC: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Prolactin: {\n    aliases: {\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  RBC: {\n    aliases: {\n      '/ul': '/uL',\n      '/µl': '/uL',\n      '10*6/ul': 'M/uL',\n      'cells/ul': '/uL',\n      'm/ul': 'M/uL',\n      'milhões/mm3': 'M/uL',\n      'milhões/mm³': 'M/uL',\n      'x10e6/ul': 'M/uL',\n    },\n    canonicalUcum: '10*6/uL',\n    canonicalUnit: 'M/uL',\n    siUcum: '10*6/uL',\n    siUnit: 'M/uL',\n  },\n  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  TestosteroneFree: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 288.42,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  TIBC: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Triglycerides: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 885.4,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  TSH: {\n    aliases: {\n      'miu/l': 'uIU/mL',\n      'mui/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'mIU/L',\n    siUnit: 'mIU/L',\n  },\n  Urea: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 60.06,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  VATVolume: {\n    aliases: { cm3: 'cm3', 'cm³': 'cm3', in3: '[in_i]3', 'in³': '[in_i]3' },\n    canonicalUcum: 'cm3',\n    canonicalUnit: 'cm³',\n    siUcum: 'cm3',\n    siUnit: 'cm³',\n  },\n  VitaminB12: {\n    aliases: { 'ng/l': 'pg/mL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  VitaminD: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 384.64,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n};\n\n/**\n * Get the canonical unit for a biomarker code.\n */\nexport function getCanonicalUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;\n}\n\n/**\n * Get the SI unit for a biomarker code.\n */\nexport function getSIUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.siUnit ?? null;\n}\n\n// ─── Unit Conversion ────────────────────────────────────────────────────────────\n\n/**\n * Normalize a unit string to its canonical display form for a given biomarker.\n * Returns the input unchanged if no alias is found.\n */\nfunction normalizeUnit(unit: string, config: BiomarkerUnitConfig): string {\n  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;\n}\n\n/**\n * Conversion factor tables for unit pairs that don't require molecular weight.\n * Key format: \"fromUnit -> toUnit\" (using canonical display forms).\n * Both directions must be listed explicitly — there is no auto-inversion.\n */\nconst FIXED_FACTORS: Record<string, number> = {\n  'g/dL -> g/L': 10,\n  'g/L -> g/dL': 0.1,\n  'ng/dL -> pg/mL': 10,\n  'ng/mL -> µg/L': 1,\n  'pg/mL -> ng/dL': 0.1,\n  'µg/L -> ng/mL': 1,\n};\n\n/**\n * MW-based conversion definitions.\n * Each entry maps a (fromUnit, toUnit) pair to the formula:\n *   result = value × numerator / (MW × denominator)\n *\n * Common patterns:\n *   mg/dL  → mmol/L:  value × 10   / MW\n *   mg/dL  → µmol/L:  value × 10000 / MW  (or equivalently × 10 / MW × 1000)\n *   ng/mL  → nmol/L:  value × 1000 / MW\n *   pg/mL  → pmol/L:  value × 1000 / MW\n *   ng/dL  → nmol/L:  value × 10   / MW\n */\n/**\n * MW conversion entries. Each direction is explicit to avoid fragile inversion logic.\n * Formula: result = value × scale / MW  (when divideByMW is true)\n *          result = value × MW / scale  (when divideByMW is false)\n */\ninterface MWConversion {\n  divideByMW: boolean;\n  scale: number;\n}\n\nconst MW_CONVERSIONS: Record<string, MWConversion> = {\n  'mg/dL -> mmol/L': { divideByMW: true, scale: 10 },\n  'mg/dL -> µmol/L': { divideByMW: true, scale: 10_000 },\n  'mmol/L -> mg/dL': { divideByMW: false, scale: 10 },\n  'ng/dL -> nmol/L': { divideByMW: true, scale: 10 },\n  'ng/mL -> nmol/L': { divideByMW: true, scale: 1000 },\n  'nmol/L -> ng/dL': { divideByMW: false, scale: 10 },\n  'nmol/L -> ng/mL': { divideByMW: false, scale: 1000 },\n  'pg/mL -> pmol/L': { divideByMW: true, scale: 1000 },\n  'pmol/L -> pg/mL': { divideByMW: false, scale: 1000 },\n  'µmol/L -> mg/dL': { divideByMW: false, scale: 10_000 },\n};\n\nexport interface ConversionResult {\n  unit: string;\n  value: number;\n}\n\n/**\n * Convert a biomarker value between units.\n *\n * Supports:\n * - Fixed-factor conversions (e.g. ng/dL ↔ pg/mL, g/dL ↔ g/L)\n * - Molecular-weight-based conversions (e.g. mg/dL ↔ mmol/L, pg/mL ↔ pmol/L)\n *\n * @returns The converted value and target unit, or null if conversion is not possible.\n */\nexport function convertUnit(\n  value: number,\n  fromUnit: string,\n  toUnit: string,\n  biomarkerCode: string,\n): ConversionResult | null {\n  const config = BIOMARKER_UNITS[biomarkerCode];\n  if (!config) return null;\n\n  const normFrom = normalizeUnit(fromUnit, config);\n  const normTo = normalizeUnit(toUnit, config);\n\n  if (normFrom === normTo) {\n    return { unit: normTo, value };\n  }\n\n  const key = `${normFrom} -> ${normTo}`;\n\n  const fixedFactor = FIXED_FACTORS[key];\n  if (fixedFactor !== undefined) {\n    return { unit: normTo, value: value * fixedFactor };\n  }\n\n  const mwConv = MW_CONVERSIONS[key];\n  if (mwConv && config.molecularWeight) {\n    const result = mwConv.divideByMW\n      ? (value * mwConv.scale) / config.molecularWeight\n      : (value * config.molecularWeight) / mwConv.scale;\n    return { unit: normTo, value: result };\n  }\n\n  return 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