@precisa-saude/fhir 0.8.0 → 0.10.0

package/dist/chunk-R4MUCMO3.js

@@ -0,0 +1,917 @@
+// src/units.ts
+var UNIT_TO_UCUM = {
+  // Dimensionless / special measurements
+  "[pH]": "[pH]",
+  "{ratio}": "{ratio}",
+  "{specific gravity}": "{specific gravity}",
+  "/\xB5L": "/uL",
+  // Percentage
+  "%": "%",
+  // Count units
+  "10\xB3/\xB5L": "10*3/uL",
+  "10\u2076/\xB5L": "10*6/uL",
+  // Volume
+  fL: "fL",
+  g: "g",
+  // Mass concentration
+  "g/dL": "g/dL",
+  L: "L",
+  // Molar concentration
+  "mEq/L": "meq/L",
+  mg: "mg",
+  "mg/dL": "mg/dL",
+  mL: "mL",
+  "mmol/L": "mmol/L",
+  "mUI/mL": "m[IU]/mL",
+  ng: "ng",
+  "ng/dL": "ng/dL",
+  "ng/mL": "ng/mL",
+  "nmol/L": "nmol/L",
+  // Mass
+  pg: "pg",
+  "pg/mL": "pg/mL",
+  pH: "[pH]",
+  // Enzyme activity
+  "U/L": "U/L",
+  // Special units
+  "U/mL": "U/mL",
+  "UI/L": "[IU]/L",
+  "UI/mL": "[IU]/mL",
+  \u00B5g: "ug",
+  "\xB5g/dL": "ug/dL",
+  "\xB5mol/L": "umol/L",
+  "\xB5UI/mL": "u[IU]/mL"
+};
+var BIOMARKER_DEFAULT_UNIT = {
+  // Proteins
+  Albumin: "g/dL",
+  AlkalinePhosphatase: "U/L",
+  // Liver
+  ALT: "U/L",
+  AST: "U/L",
+  Calcium: "mg/dL",
+  Chloride: "mEq/L",
+  // Lipids
+  Cholesterol: "mg/dL",
+  // Kidney
+  Creatinine: "mg/dL",
+  eAG: "mg/dL",
+  Ferritin: "ng/mL",
+  FolicAcid: "ng/mL",
+  GGT: "U/L",
+  // Glucose/Diabetes
+  Glucose: "mg/dL",
+  HbA1c: "%",
+  Hct: "%",
+  HDL: "mg/dL",
+  // Hematology
+  Hgb: "g/dL",
+  Insulin: "\xB5UI/mL",
+  // Iron studies
+  Iron: "\xB5g/dL",
+  LDL: "mg/dL",
+  Magnesium: "mg/dL",
+  NonHDL_Cholesterol: "mg/dL",
+  // Urinalysis - dimensionless
+  pH_Urine: "[pH]",
+  Potassium: "mEq/L",
+  RDW: "%",
+  // Electrolytes
+  Sodium: "mEq/L",
+  SpecificGravity_Urine: "{specific gravity}",
+  T3Free: "pg/mL",
+  T4Free: "ng/dL",
+  TIBC: "\xB5g/dL",
+  TotalProtein: "g/dL",
+  TransferrinSaturation: "%",
+  Triglycerides: "mg/dL",
+  // Thyroid
+  TSH: "\xB5UI/mL",
+  Urea: "mg/dL",
+  UricAcid: "mg/dL",
+  // Vitamins
+  VitaminB12: "pg/mL",
+  VitaminD: "ng/mL",
+  VLDL: "mg/dL"
+};
+function unitToUCUM(unit) {
+  return UNIT_TO_UCUM[unit] || unit;
+}
+function getDefaultUnit(biomarkerCode) {
+  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || "";
+}
+var CBC_DIFF_ALIASES = {
+  "/ul": "/uL",
+  "/\xB5l": "/uL",
+  "10*3/ul": "K/uL",
+  "cells/ul": "/uL",
+  "cells/\xB5l": "/uL",
+  "k/ul": "K/uL",
+  "x10e3/ul": "K/uL"
+};
+var CBC_DIFF = {
+  canonicalUcum: "10*3/uL",
+  canonicalUnit: "K/uL",
+  siUcum: "10*3/uL",
+  siUnit: "K/uL"
+};
+var DEXA_KG_ALIASES = {
+  kg: "kg",
+  lb: "[lb_av]",
+  lbs: "[lb_av]"
+};
+var DEXA_KG = {
+  canonicalUcum: "kg",
+  canonicalUnit: "kg",
+  siUcum: "kg",
+  siUnit: "kg"
+};
+var URINE_SEDIMENT_ALIASES = {
+  "/hpf": "/HPF",
+  "/ml": "/mL"
+};
+var URINE_SEDIMENT = {
+  canonicalUcum: "/[HPF]",
+  canonicalUnit: "/HPF",
+  siUcum: "/[HPF]",
+  siUnit: "/HPF"
+};
+var PERCENTAGE_ALIASES = { "%": "%", pct: "%", percent: "%" };
+var PERCENTAGE = {
+  canonicalUcum: "%",
+  canonicalUnit: "%",
+  siUcum: "%",
+  siUnit: "%"
+};
+var ENZYME_ALIASES = { "iu/l": "U/L", "u/l": "U/L" };
+var ENZYME = {
+  canonicalUcum: "U/L",
+  canonicalUnit: "U/L",
+  siUcum: "U/L",
+  siUnit: "U/L"
+};
+var ELECTROLYTE_MONO_ALIASES = { "meq/l": "mEq/L", "mmol/l": "mmol/L" };
+var ELECTROLYTE_MONO = {
+  canonicalUcum: "meq/L",
+  canonicalUnit: "mEq/L",
+  siUcum: "mmol/L",
+  siUnit: "mmol/L"
+};
+var CAC_ALIASES = { au: "AU" };
+var CAC = {
+  canonicalUcum: "{score}",
+  canonicalUnit: "AU",
+  siUcum: "{score}",
+  siUnit: "AU"
+};
+var NMOL_L_ALIASES = { "nmol/l": "nmol/L" };
+var NMOL_L = {
+  canonicalUcum: "nmol/L",
+  canonicalUnit: "nmol/L",
+  siUcum: "nmol/L",
+  siUnit: "nmol/L"
+};
+var BIOMARKER_UNITS = {
+  AFP: {
+    aliases: { "ng/ml": "ng/mL" },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    siUcum: "ng/mL",
+    siUnit: "ng/mL"
+  },
+  Albumin: {
+    aliases: { "g/dl": "g/dL", "g/l": "g/L" },
+    canonicalUcum: "g/dL",
+    canonicalUnit: "g/dL",
+    siUcum: "g/L",
+    siUnit: "g/L"
+  },
+  AlkalinePhosphatase: { aliases: ENZYME_ALIASES, ...ENZYME },
+  ALT: { aliases: ENZYME_ALIASES, ...ENZYME },
+  AMH: {
+    aliases: { "ng/ml": "ng/mL", "pmol/l": "pmol/L" },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    molecularWeight: 12500,
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  Amylase: { aliases: ENZYME_ALIASES, ...ENZYME },
+  AntiThyroglobulin: {
+    aliases: { "iu/ml": "IU/mL", "ui/ml": "IU/mL" },
+    canonicalUcum: "[iU]/mL",
+    canonicalUnit: "IU/mL",
+    siUcum: "[iU]/mL",
+    siUnit: "IU/mL"
+  },
+  AntiTPO: {
+    aliases: { "iu/ml": "IU/mL", "ui/ml": "IU/mL" },
+    canonicalUcum: "[iU]/mL",
+    canonicalUnit: "IU/mL",
+    siUcum: "[iU]/mL",
+    siUnit: "IU/mL"
+  },
+  AoA1: {
+    aliases: { "mg/dl": "mg/dL" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    siUcum: "mg/dL",
+    siUnit: "mg/dL"
+  },
+  AorticValveCalcium: { aliases: CAC_ALIASES, ...CAC },
+  ApoB: {
+    aliases: { "mg/dl": "mg/dL" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    siUcum: "mg/dL",
+    siUnit: "mg/dL"
+  },
+  AST: { aliases: ENZYME_ALIASES, ...ENZYME },
+  Basophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  BilirubinDirect: {
+    aliases: { "mg/dl": "mg/dL", "\xB5mol/l": "\xB5mol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 584.66,
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  BilirubinIndirect: {
+    aliases: { "mg/dl": "mg/dL", "\xB5mol/l": "\xB5mol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 584.66,
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  BilirubinTotal: {
+    aliases: { "mg/dl": "mg/dL", "\xB5mol/l": "\xB5mol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 584.66,
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  BMI: {
+    aliases: { "kg/m2": "kg/m\xB2", "kg/m\xB2": "kg/m\xB2" },
+    canonicalUcum: "kg/m2",
+    canonicalUnit: "kg/m\xB2",
+    siUcum: "kg/m2",
+    siUnit: "kg/m\xB2"
+  },
+  BNP: {
+    aliases: { "pg/ml": "pg/mL" },
+    canonicalUcum: "pg/mL",
+    canonicalUnit: "pg/mL",
+    siUcum: "pg/mL",
+    siUnit: "pg/mL"
+  },
+  CA125: {
+    aliases: { "u/ml": "U/mL" },
+    canonicalUcum: "U/mL",
+    canonicalUnit: "U/mL",
+    siUcum: "U/mL",
+    siUnit: "U/mL"
+  },
+  CAC_LAD: { aliases: CAC_ALIASES, ...CAC },
+  CAC_LCX: { aliases: CAC_ALIASES, ...CAC },
+  CAC_LMA: { aliases: CAC_ALIASES, ...CAC },
+  CAC_RCA: { aliases: CAC_ALIASES, ...CAC },
+  Calcium: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 40.08,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  CEA: {
+    aliases: { "ng/ml": "ng/mL" },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    siUcum: "ng/mL",
+    siUnit: "ng/mL"
+  },
+  Chloride: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },
+  Cholesterol: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 386.65,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  CK: { aliases: ENZYME_ALIASES, ...ENZYME },
+  CO2: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },
+  Cortisol: {
+    aliases: { "mcg/dl": "\xB5g/dL", "nmol/l": "nmol/L", "ug/dl": "\xB5g/dL", "\xB5g/dl": "\xB5g/dL" },
+    canonicalUcum: "ug/dL",
+    canonicalUnit: "\xB5g/dL",
+    molecularWeight: 362.46,
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
+  Creatinine: {
+    aliases: { "mg/dl": "mg/dL", "umol/l": "\xB5mol/L", "\xB5mol/l": "\xB5mol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 113.12,
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  CRP: {
+    aliases: { "mg/dl": "mg/dL", "mg/l": "mg/L" },
+    canonicalUcum: "mg/L",
+    canonicalUnit: "mg/L",
+    siUcum: "mg/L",
+    siUnit: "mg/L"
+  },
+  DHEAS: {
+    aliases: { "mcg/dl": "\xB5g/dL", "ug/dl": "\xB5g/dL", "\xB5g/dl": "\xB5g/dL", "\xB5mol/l": "\xB5mol/L" },
+    canonicalUcum: "ug/dL",
+    canonicalUnit: "\xB5g/dL",
+    molecularWeight: 368.49,
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  DHT: {
+    aliases: { "ng/dl": "ng/dL", "nmol/l": "nmol/L" },
+    canonicalUcum: "ng/dL",
+    canonicalUnit: "ng/dL",
+    molecularWeight: 290.44,
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
+  eGFR: {
+    aliases: {
+      "ml/min/1,73 m2": "mL/min/1.73m\xB2",
+      "ml/min/1.73m2": "mL/min/1.73m\xB2",
+      "ml/min/1.73m\xB2": "mL/min/1.73m\xB2"
+    },
+    canonicalUcum: "mL/min/{1.73_m2}",
+    canonicalUnit: "mL/min/1.73m\xB2",
+    siUcum: "mL/min/{1.73_m2}",
+    siUnit: "mL/min/1.73m\xB2"
+  },
+  Eosinophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  EPADPADHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  ESR: {
+    aliases: { "mm/h": "mm/h", "mm/hr": "mm/h" },
+    canonicalUcum: "mm/h",
+    canonicalUnit: "mm/h",
+    siUcum: "mm/h",
+    siUnit: "mm/h"
+  },
+  Estradiol: {
+    aliases: { "ng/dl": "ng/dL", "pg/ml": "pg/mL" },
+    canonicalUcum: "pg/mL",
+    canonicalUnit: "pg/mL",
+    molecularWeight: 272.38,
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  Ferritin: {
+    aliases: {
+      "mcg/l": "ng/mL",
+      "microg/l": "ng/mL",
+      "ng/ml": "ng/mL",
+      "\xB5g/l": "ng/mL"
+    },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    siUcum: "ug/L",
+    siUnit: "\xB5g/L"
+  },
+  Folate: {
+    aliases: { "ng/ml": "ng/mL", "nmol/l": "nmol/L" },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    molecularWeight: 441.4,
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
+  FSH: {
+    aliases: {
+      "iu/l": "mIU/mL",
+      "miu/ml": "mIU/mL",
+      "ui/l": "mIU/mL"
+    },
+    canonicalUcum: "mIU/mL",
+    canonicalUnit: "mIU/mL",
+    siUcum: "[iU]/L",
+    siUnit: "IU/L"
+  },
+  GGT: { aliases: ENZYME_ALIASES, ...ENZYME },
+  Globulin: {
+    aliases: { "g/dl": "g/dL", "g/l": "g/L" },
+    canonicalUcum: "g/dL",
+    canonicalUnit: "g/dL",
+    siUcum: "g/L",
+    siUnit: "g/L"
+  },
+  Glucose: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 180.156,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  HbA1c: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Hct: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  HDL: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 386.65,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  HDL_Large: { aliases: NMOL_L_ALIASES, ...NMOL_L },
+  Hgb: {
+    aliases: { "g/dl": "g/dL", "g/l": "g/L" },
+    canonicalUcum: "g/dL",
+    canonicalUnit: "g/dL",
+    siUcum: "g/L",
+    siUnit: "g/L"
+  },
+  Homocysteine: {
+    aliases: { "umol/l": "\xB5mol/L", "\xB5mol/l": "\xB5mol/L" },
+    canonicalUcum: "umol/L",
+    canonicalUnit: "\xB5mol/L",
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  IgA: {
+    aliases: { "g/l": "g/L", "mg/dl": "mg/dL" },
+    canonicalUcum: "g/L",
+    canonicalUnit: "g/L",
+    siUcum: "g/L",
+    siUnit: "g/L"
+  },
+  IgG: {
+    aliases: { "g/l": "g/L", "mg/dl": "mg/dL" },
+    canonicalUcum: "g/L",
+    canonicalUnit: "g/L",
+    siUcum: "g/L",
+    siUnit: "g/L"
+  },
+  INR: {
+    aliases: { "{ratio}": "{ratio}" },
+    canonicalUcum: "{ratio}",
+    canonicalUnit: "{ratio}",
+    siUcum: "{ratio}",
+    siUnit: "{ratio}"
+  },
+  Insulin: {
+    aliases: {
+      "mu/l": "uIU/mL",
+      "uiu/ml": "uIU/mL",
+      "\xB5u/ml": "uIU/mL",
+      "\xB5ui/ml": "uIU/mL"
+    },
+    canonicalUcum: "u[iU]/mL",
+    canonicalUnit: "uIU/mL",
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  Iron: {
+    aliases: {
+      "mcg/dl": "mcg/dL",
+      "microg/dl": "mcg/dL",
+      "ug/dl": "mcg/dL",
+      "\xB5g/dl": "mcg/dL"
+    },
+    canonicalUcum: "ug/dL",
+    canonicalUnit: "mcg/dL",
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  LDL: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 386.65,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  LDL_Medium: { aliases: NMOL_L_ALIASES, ...NMOL_L },
+  LDL_ParticleNumber: { aliases: NMOL_L_ALIASES, ...NMOL_L },
+  LDL_Peak_Size: {
+    aliases: { \u00E5: "Ao", angstrom: "Ao", ao: "Ao", nm: "nm" },
+    canonicalUcum: "Ao",
+    canonicalUnit: "Angstrom",
+    siUcum: "nm",
+    siUnit: "nm"
+  },
+  LDL_Small: { aliases: NMOL_L_ALIASES, ...NMOL_L },
+  Lead: {
+    aliases: { "mcg/dl": "\xB5g/dL", "ug/dl": "\xB5g/dL", "\xB5g/dl": "\xB5g/dL", "\xB5mol/l": "\xB5mol/L" },
+    canonicalUcum: "ug/dL",
+    canonicalUnit: "\xB5g/dL",
+    molecularWeight: 207.2,
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  Leptin: {
+    aliases: { "ng/ml": "ng/mL" },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    siUcum: "ng/mL",
+    siUnit: "ng/mL"
+  },
+  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },
+  LH: {
+    aliases: {
+      "iu/l": "mIU/mL",
+      "miu/ml": "mIU/mL",
+      "ui/l": "mIU/mL"
+    },
+    canonicalUcum: "mIU/mL",
+    canonicalUnit: "mIU/mL",
+    siUcum: "[iU]/L",
+    siUnit: "IU/L"
+  },
+  Lipase: { aliases: ENZYME_ALIASES, ...ENZYME },
+  Lipoprotein_a: {
+    aliases: { "mg/dl": "mg/dL", "nmol/l": "nmol/L" },
+    canonicalUcum: "nmol/L",
+    canonicalUnit: "nmol/L",
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
+  Lymphocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  MCH: {
+    aliases: { pg: "pg" },
+    canonicalUcum: "pg",
+    canonicalUnit: "pg",
+    siUcum: "pg",
+    siUnit: "pg"
+  },
+  MCHC: {
+    aliases: { "g/dl": "g/dL", "g/l": "g/L" },
+    canonicalUcum: "g/dL",
+    canonicalUnit: "g/dL",
+    siUcum: "g/L",
+    siUnit: "g/L"
+  },
+  MCV: {
+    aliases: { fl: "fL" },
+    canonicalUcum: "fL",
+    canonicalUnit: "fL",
+    siUcum: "fL",
+    siUnit: "fL"
+  },
+  Mercury: {
+    aliases: { "mcg/l": "\xB5g/L", "nmol/l": "nmol/L", "ug/l": "\xB5g/L", "\xB5g/l": "\xB5g/L" },
+    canonicalUcum: "ug/L",
+    canonicalUnit: "\xB5g/L",
+    molecularWeight: 200.59,
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
+  Microalbumin_Urine: {
+    aliases: { "mg/l": "mg/L" },
+    canonicalUcum: "mg/L",
+    canonicalUnit: "mg/L",
+    siUcum: "mg/L",
+    siUnit: "mg/L"
+  },
+  MMA: { aliases: NMOL_L_ALIASES, ...NMOL_L },
+  Monocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  MPV: {
+    aliases: { fl: "fL" },
+    canonicalUcum: "fL",
+    canonicalUnit: "fL",
+    siUcum: "fL",
+    siUnit: "fL"
+  },
+  Myeloperoxidase: {
+    aliases: { "pmol/l": "pmol/L" },
+    canonicalUcum: "pmol/L",
+    canonicalUnit: "pmol/L",
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  Neutrophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  // MW 386.65 = colesterol livre. Frações lipoproteicas são heterogêneas,
+  // mas a conversão mg/dL→mmol/L usa MW do colesterol por convenção clínica.
+  NonHDL_Cholesterol: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 386.65,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  NTproBNP: {
+    aliases: { "pg/ml": "pg/mL" },
+    canonicalUcum: "pg/mL",
+    canonicalUnit: "pg/mL",
+    siUcum: "pg/mL",
+    siUnit: "pg/mL"
+  },
+  Omega3_DHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Omega3_DPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Omega3_EPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Omega3_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Omega6_AA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Omega6_LA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Omega6_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  Potassium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },
+  Progesterone: {
+    aliases: { "ng/ml": "ng/mL", "nmol/l": "nmol/L" },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    molecularWeight: 314.46,
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
+  Prolactin: {
+    aliases: {
+      "microg/l": "ng/mL",
+      "ng/ml": "ng/mL",
+      "\xB5g/l": "ng/mL"
+    },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    siUcum: "ug/L",
+    siUnit: "\xB5g/L"
+  },
+  ProthrombinTime: {
+    aliases: { s: "s", sec: "s" },
+    canonicalUcum: "s",
+    canonicalUnit: "s",
+    siUcum: "s",
+    siUnit: "s"
+  },
+  PSA: {
+    aliases: { "ng/ml": "ng/mL" },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    siUcum: "ng/mL",
+    siUnit: "ng/mL"
+  },
+  PSA_Free: {
+    aliases: { "ng/ml": "ng/mL" },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    siUcum: "ng/mL",
+    siUnit: "ng/mL"
+  },
+  RBC: {
+    aliases: {
+      "/ul": "/uL",
+      "/\xB5l": "/uL",
+      "10*6/ul": "M/uL",
+      "cells/ul": "/uL",
+      "m/ul": "M/uL",
+      "milh\xF5es/mm3": "M/uL",
+      "milh\xF5es/mm\xB3": "M/uL",
+      "x10e6/ul": "M/uL"
+    },
+    canonicalUcum: "10*6/uL",
+    canonicalUnit: "M/uL",
+    siUcum: "10*6/uL",
+    siUnit: "M/uL"
+  },
+  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },
+  RDW: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  Reticulocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },
+  RheumatoidFactor: {
+    aliases: { "iu/ml": "IU/mL", "ui/ml": "IU/mL" },
+    canonicalUcum: "[iU]/mL",
+    canonicalUnit: "IU/mL",
+    siUcum: "[iU]/mL",
+    siUnit: "IU/mL"
+  },
+  SHBG: { aliases: NMOL_L_ALIASES, ...NMOL_L },
+  Sodium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },
+  T3Free: {
+    aliases: { "pg/ml": "pg/mL", "pmol/l": "pmol/L" },
+    canonicalUcum: "pg/mL",
+    canonicalUnit: "pg/mL",
+    molecularWeight: 650.98,
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  T4Free: {
+    aliases: { "ng/dl": "ng/dL", "pmol/l": "pmol/L" },
+    canonicalUcum: "ng/dL",
+    canonicalUnit: "ng/dL",
+    molecularWeight: 776.87,
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  T4Total: {
+    aliases: { "mcg/dl": "\xB5g/dL", "nmol/l": "nmol/L", "ug/dl": "\xB5g/dL", "\xB5g/dl": "\xB5g/dL" },
+    canonicalUcum: "ug/dL",
+    canonicalUnit: "\xB5g/dL",
+    molecularWeight: 776.87,
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
+  Testosterone: {
+    aliases: { "ng/dl": "ng/dL", "nmol/l": "nmol/L" },
+    canonicalUcum: "ng/dL",
+    canonicalUnit: "ng/dL",
+    molecularWeight: 288.42,
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
+  TestosteroneFree: {
+    aliases: { "pg/ml": "pg/mL", "pmol/l": "pmol/L" },
+    canonicalUcum: "pg/mL",
+    canonicalUnit: "pg/mL",
+    molecularWeight: 288.42,
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  TIBC: {
+    aliases: {
+      "mcg/dl": "mcg/dL",
+      "microg/dl": "mcg/dL",
+      "ug/dl": "mcg/dL",
+      "\xB5g/dl": "mcg/dL"
+    },
+    canonicalUcum: "ug/dL",
+    canonicalUnit: "mcg/dL",
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  TotalProtein: {
+    aliases: { "g/dl": "g/dL", "g/l": "g/L" },
+    canonicalUcum: "g/dL",
+    canonicalUnit: "g/dL",
+    siUcum: "g/L",
+    siUnit: "g/L"
+  },
+  Triglycerides: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 885.4,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  TroponinI: {
+    aliases: { "ng/ml": "ng/mL" },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    siUcum: "ng/mL",
+    siUnit: "ng/mL"
+  },
+  TroponinT: {
+    aliases: { "ng/l": "ng/L" },
+    canonicalUcum: "ng/L",
+    canonicalUnit: "ng/L",
+    siUcum: "ng/L",
+    siUnit: "ng/L"
+  },
+  TSH: {
+    aliases: {
+      "miu/l": "uIU/mL",
+      "mui/l": "uIU/mL",
+      "uiu/ml": "uIU/mL",
+      "\xB5ui/ml": "uIU/mL"
+    },
+    canonicalUcum: "u[iU]/mL",
+    canonicalUnit: "uIU/mL",
+    siUcum: "mIU/L",
+    siUnit: "mIU/L"
+  },
+  Urea: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 60.06,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  UricAcid: {
+    aliases: { "mg/dl": "mg/dL", "\xB5mol/l": "\xB5mol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 168.11,
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  VATVolume: {
+    aliases: { cm3: "cm3", "cm\xB3": "cm3", in3: "[in_i]3", "in\xB3": "[in_i]3" },
+    canonicalUcum: "cm3",
+    canonicalUnit: "cm\xB3",
+    siUcum: "cm3",
+    siUnit: "cm\xB3"
+  },
+  VitaminB12: {
+    aliases: { "ng/l": "pg/mL", "pg/ml": "pg/mL" },
+    canonicalUcum: "pg/mL",
+    canonicalUnit: "pg/mL",
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  VitaminD: {
+    aliases: { "ng/ml": "ng/mL", "nmol/l": "nmol/L" },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    molecularWeight: 384.64,
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
+  VLDL: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 386.65,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF }
+};
+function getCanonicalUnit(code) {
+  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;
+}
+function getSIUnit(code) {
+  return BIOMARKER_UNITS[code]?.siUnit ?? null;
+}
+function normalizeUnit(unit, config) {
+  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;
+}
+var FIXED_FACTORS = {
+  "g/dL -> g/L": 10,
+  "g/L -> g/dL": 0.1,
+  "g/L -> mg/dL": 100,
+  "mEq/L -> mmol/L": 1,
+  "mg/dL -> g/L": 0.01,
+  "mmol/L -> mEq/L": 1,
+  "ng/dL -> pg/mL": 10,
+  "ng/mL -> \xB5g/L": 1,
+  "pg/mL -> ng/dL": 0.1,
+  "\xB5g/L -> ng/mL": 1
+};
+var MW_CONVERSIONS = {
+  "mg/dL -> mmol/L": { divideByMW: true, scale: 10 },
+  "mg/dL -> \xB5mol/L": { divideByMW: true, scale: 1e4 },
+  "mmol/L -> mg/dL": { divideByMW: false, scale: 10 },
+  "ng/dL -> nmol/L": { divideByMW: true, scale: 10 },
+  "ng/dL -> pmol/L": { divideByMW: true, scale: 1e4 },
+  "ng/mL -> nmol/L": { divideByMW: true, scale: 1e3 },
+  "ng/mL -> pmol/L": { divideByMW: true, scale: 1e6 },
+  "nmol/L -> ng/dL": { divideByMW: false, scale: 10 },
+  "nmol/L -> ng/mL": { divideByMW: false, scale: 1e3 },
+  "nmol/L -> \xB5g/dL": { divideByMW: false, scale: 1e4 },
+  "nmol/L -> \xB5g/L": { divideByMW: false, scale: 1e3 },
+  "pg/mL -> pmol/L": { divideByMW: true, scale: 1e3 },
+  "pmol/L -> ng/dL": { divideByMW: false, scale: 1e4 },
+  "pmol/L -> ng/mL": { divideByMW: false, scale: 1e6 },
+  "pmol/L -> pg/mL": { divideByMW: false, scale: 1e3 },
+  "\xB5g/dL -> nmol/L": { divideByMW: true, scale: 1e4 },
+  "\xB5g/dL -> \xB5mol/L": { divideByMW: true, scale: 10 },
+  "\xB5g/L -> nmol/L": { divideByMW: true, scale: 1e3 },
+  "\xB5mol/L -> mg/dL": { divideByMW: false, scale: 1e4 },
+  "\xB5mol/L -> \xB5g/dL": { divideByMW: false, scale: 10 }
+};
+function convertUnit(value, fromUnit, toUnit, biomarkerCode) {
+  const config = BIOMARKER_UNITS[biomarkerCode];
+  if (!config) return null;
+  const normFrom = normalizeUnit(fromUnit, config);
+  const normTo = normalizeUnit(toUnit, config);
+  if (normFrom === normTo) {
+    return { unit: normTo, value };
+  }
+  const key = `${normFrom} -> ${normTo}`;
+  const fixedFactor = FIXED_FACTORS[key];
+  if (fixedFactor !== void 0) {
+    return { unit: normTo, value: value * fixedFactor };
+  }
+  const mwConv = MW_CONVERSIONS[key];
+  if (mwConv && config.molecularWeight) {
+    const result = mwConv.divideByMW ? value * mwConv.scale / config.molecularWeight : value * config.molecularWeight / mwConv.scale;
+    return { unit: normTo, value: result };
+  }
+  return null;
+}
+
+export {
+  UNIT_TO_UCUM,
+  BIOMARKER_DEFAULT_UNIT,
+  unitToUCUM,
+  getDefaultUnit,
+  BIOMARKER_UNITS,
+  getCanonicalUnit,
+  getSIUnit,
+  convertUnit
+};
+//# sourceMappingURL=chunk-R4MUCMO3.js.map