@precisa-saude/fhir 0.37.2 → 0.38.1

package/dist/{chunk-RWUFK5AN.cjs → chunk-IY6BZX2V.cjs}

@@ -1,6 +1,6 @@
 "use strict";Object.defineProperty(exports, "__esModule", {value: true}); function _nullishCoalesce(lhs, rhsFn) { if (lhs != null) { return lhs; } else { return rhsFn(); } } function _optionalChain(ops) { let lastAccessLHS = undefined; let value = ops[0]; let i = 1; while (i < ops.length) { const op = ops[i]; const fn = ops[i + 1]; i += 2; if ((op === 'optionalAccess' || op === 'optionalCall') && value == null) { return undefined; } if (op === 'access' || op === 'optionalAccess') { lastAccessLHS = value; value = fn(value); } else if (op === 'call' || op === 'optionalCall') { value = fn((...args) => value.call(lastAccessLHS, ...args)); lastAccessLHS = undefined; } } return value; }
 
-var _chunkBDS6CM7Fcjs = require('./chunk-BDS6CM7F.cjs');
+var _chunkVMID6CDCcjs = require('./chunk-VMID6CDC.cjs');
 
 // src/units.ts
 var UNIT_TO_UCUM = {
@@ -96,7 +96,7 @@ var DIMENSIONLESS_DEFAULTS = {
 };
 var BIOMARKER_DEFAULT_UNIT = {
   ...Object.fromEntries(
-    _chunkBDS6CM7Fcjs.BIOMARKER_DEFINITIONS.filter((b) => b.unit).map((b) => [b.code, b.unit])
+    _chunkVMID6CDCcjs.BIOMARKER_DEFINITIONS.filter((b) => b.unit).map((b) => [b.code, b.unit])
   ),
   ...DIMENSIONLESS_DEFAULTS
 };
@@ -396,6 +396,17 @@ var BIOMARKER_UNITS = {
     siUcum: "pg/mL",
     siUnit: "pg/mL"
   },
+  // O BUN em mmol/L é expresso como ureia: cada molécula de ureia tem dois
+  // nitrogênios, então a massa que entra na conversão é a de N2 (2 × 14,007),
+  // e não a da ureia (60,06) usada em `Urea`. 14 mg/dL de BUN ≈ 5 mmol/L.
+  BUN: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 28.0134,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
   CA125: {
     aliases: { "u/ml": "U/mL" },
     canonicalUcum: "U/mL",
@@ -836,6 +847,14 @@ var BIOMARKER_UNITS = {
     siUcum: "pmol/L",
     siUnit: "pmol/L"
   },
+  T3Total: {
+    aliases: { "ng/dl": "ng/dL", "nmol/l": "nmol/L" },
+    canonicalUcum: "ng/dL",
+    canonicalUnit: "ng/dL",
+    molecularWeight: 650.98,
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
   T4Free: {
     aliases: { "ng/dl": "ng/dL", "pmol/l": "pmol/L" },
     canonicalUcum: "ng/dL",
@@ -1073,4 +1092,4 @@ function resolveUcum(unit, biomarkerCode) {
 
 
 exports.UNIT_TO_UCUM = UNIT_TO_UCUM; exports.BIOMARKER_DEFAULT_UNIT = BIOMARKER_DEFAULT_UNIT; exports.unitToUCUM = unitToUCUM; exports.getDefaultUnit = getDefaultUnit; exports.isUcumCode = isUcumCode; exports.BIOMARKER_UNITS = BIOMARKER_UNITS; exports.getCanonicalUnit = getCanonicalUnit; exports.getSIUnit = getSIUnit; exports.convertUnit = convertUnit; exports.resolveUcum = resolveUcum;
-//# sourceMappingURL=chunk-RWUFK5AN.cjs.map
+//# sourceMappingURL=chunk-IY6BZX2V.cjs.map

package/dist/chunk-IY6BZX2V.cjs.map

@@ -0,0 +1 @@
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* Unit Mappings and Biomarker Unit Definitions\n *\n * Maps units to UCUM format, provides default units for biomarkers,\n * and defines canonical/SI unit configurations with aliases.\n */\n\nimport { BIOMARKER_DEFINITIONS } from './biomarkers';\n\n// ─── UCUM Mappings ───────────────────────────────────────────────────────────\n\n/**\n * Grafia impressa → código UCUM (Unified Code for Units of Measure).\n *\n * É a segunda fonte de `resolveUcum`, atrás de `BIOMARKER_UNITS`, e a única\n * para unidade que nenhum biomarcador configura. Cobre toda unidade declarada\n * em `biomarkers.ts`: o teste `loinc-axes.test.ts` confere isso, porque uma\n * unidade sem entrada aqui saía no FHIR como `code` sob o system do UCUM sem\n * ser UCUM (`uIU/mL`, `K/uL`, `razão`).\n *\n * `[IU]` e `[iU]` são o mesmo átomo no UCUM, nas grafias sensível e\n * insensível a caixa; esta tabela usa `[IU]` e `BIOMARKER_UNITS` usa `[iU]`.\n *\n * @see https://ucum.org/\n */\nexport const UNIT_TO_UCUM: Record<string, string> = {\n  // Dimensionless / special measurements\n  '[pH]': '[pH]',\n  '{index}': '{index}',\n  '{ratio}': '{ratio}',\n  '{score}': '{score}',\n  '{specific gravity}': '{specific gravity}',\n\n  '/HPF': '/[HPF]',\n  '/LPF': '/[LPF]',\n  '/µL': '/uL',\n  // Percentage\n  '%': '%',\n  // Count units\n  '10³/µL': '10*3/uL',\n  '10⁶/µL': '10*6/uL',\n  Angstrom: 'Ao',\n  AU: '{score}',\n  cm: 'cm',\n  'cm³': 'cm3',\n  deg: 'deg',\n  // Volume\n  fL: 'fL',\n  g: 'g',\n  'g/cm²': 'g/cm2',\n\n  // Mass concentration\n  'g/dL': 'g/dL',\n  'g/L': 'g/L',\n  'IU/L': '[IU]/L',\n  'IU/mL': '[IU]/mL',\n  'K/uL': '10*3/uL',\n  'kcal/d': 'kcal/d',\n  kg: 'kg',\n  'kg/m2': 'kg/m2',\n  'kg/m²': 'kg/m2',\n  'kU/L': 'k[IU]/L',\n  L: 'L',\n  'M/uL': '10*6/uL',\n  'mcg/dL': 'ug/dL',\n  'mcg/L': 'ug/L',\n  'mcg/mL': 'ug/mL',\n  // Molar concentration\n  'mEq/L': 'meq/L',\n\n  mg: 'mg',\n  'mg/dL': 'mg/dL',\n  'mg/g': 'mg/g',\n  'mg/L': 'mg/L',\n  'mIU/L': 'm[IU]/L',\n  'mIU/mL': 'm[IU]/mL',\n  mL: 'mL',\n  'mL/min/1.73m²': 'mL/min/{1.73_m2}',\n  mm: 'mm',\n  'mm/h': 'mm/h',\n  'mm/hr': 'mm/h',\n  'mmol/L': 'mmol/L',\n  'mUI/L': 'm[IU]/L',\n  'mUI/mL': 'm[IU]/mL',\n\n  ng: 'ng',\n\n  'ng/dL': 'ng/dL',\n  'ng/L': 'ng/L',\n  'ng/mL': 'ng/mL',\n  'nmol/L': 'nmol/L',\n  // Mass\n  pg: 'pg',\n\n  'pg/mL': 'pg/mL',\n  pH: '[pH]',\n  'pmol/L': 'pmol/L',\n  razão: '{ratio}',\n  score: '{score}',\n  segundos: 's',\n  // Enzyme activity\n  U: 'U',\n  'U/L': 'U/L',\n  // Special units\n  'U/mL': 'U/mL',\n  'ug/dL': 'ug/dL',\n  'ug/L': 'ug/L',\n  'UI/L': '[IU]/L',\n\n  'UI/mL': '[IU]/mL',\n  'uIU/mL': 'u[IU]/mL',\n  'umol/L': 'umol/L',\n\n  µg: 'ug',\n  'µg/dL': 'ug/dL',\n  'µg/L': 'ug/L',\n  'µmol/L': 'umol/L',\n  'µUI/mL': 'u[IU]/mL',\n  índice: '{index}',\n};\n\n/**\n * Unidades adimensionais de urina, que a definição não declara porque o laudo\n * não as imprime: a densidade sai como `1.020` e o pH como `6.0`, sem unidade.\n * Quando o laudo não traz unidade, o FHIR ainda precisa de uma, e estas são\n * as do UCUM.\n */\nconst DIMENSIONLESS_DEFAULTS: Record<string, string> = {\n  pH_Urine: '[pH]',\n  SpecificGravity_Urine: '{specific gravity}',\n};\n\n/**\n * Unidade padrão de cada biomarcador, usada quando o laudo não imprime uma.\n *\n * Derivada de `unit` em `biomarkers.ts`, que é a fonte única. Até out/2026\n * era uma segunda tabela escrita à mão, e as duas divergiam: TSH era\n * `µUI/mL` aqui e `uIU/mL` lá, ferro era `µg/dL` aqui e `mcg/dL` lá. Duas\n * fontes para a mesma unidade é o que faz o `fhir-bio units` e o `fhir-bio\n * range` responderem coisas diferentes para o mesmo código.\n */\nexport const BIOMARKER_DEFAULT_UNIT: Record<string, string> = {\n  ...Object.fromEntries(\n    BIOMARKER_DEFINITIONS.filter((b) => b.unit).map((b) => [b.code, b.unit as string]),\n  ),\n  ...DIMENSIONLESS_DEFAULTS,\n};\n\n/**\n * Convert unit to UCUM format\n *\n * Devolve a entrada intacta quando não conhece a unidade. Para montar um\n * `Quantity` FHIR use `resolveUcum`, que diz \"não sei\" em vez de devolver\n * uma grafia qualquer como se fosse UCUM.\n */\nexport function unitToUCUM(unit: string): string {\n  return UNIT_TO_UCUM[unit] || unit;\n}\n\n/**\n * Get default unit for a biomarker code\n * @param biomarkerCode - The biomarker code (e.g., \"Glucose\", \"HbA1c\")\n * @returns The default unit or empty string if not found\n */\nexport function getDefaultUnit(biomarkerCode: string): string {\n  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || '';\n}\n\n// ─── UCUM syntax ─────────────────────────────────────────────────────────────\n\n/**\n * Átomos do UCUM que aparecem em laudo clínico, mais as bases do SI.\n *\n * Não é a tabela inteira do UCUM, que tem centenas de átomos. É a lista que\n * basta para dizer que `uIU/mL` não é UCUM (`IU` não é átomo; `[IU]` é) e que\n * `10*3/uL` é. Átomo fora desta lista cai em \"não é UCUM\", e o jeito certo de\n * aceitá-lo é acrescentá-lo aqui, com o laudo que o imprimiu.\n */\nconst UCUM_ATOMS = new Set([\n  'm',\n  'g',\n  's',\n  'L',\n  'l',\n  'mol',\n  'eq',\n  'U',\n  'cal',\n  'h',\n  'd',\n  'min',\n  'wk',\n  'mo',\n  'a',\n  'Ao',\n  'deg',\n  'K',\n  'A',\n  'N',\n  'Pa',\n  'J',\n  'W',\n  'Hz',\n  'V',\n  'C',\n  'osm',\n  't',\n  'u',\n  'bar',\n  'atm',\n  'rad',\n  'sr',\n  'cd',\n  'Bq',\n  'Gy',\n  'Sv',\n  'lm',\n  'lx',\n  'Cel',\n  'B',\n  'Np',\n]);\n\n/** Prefixos do UCUM, do yotta ao yocto. `da` (deca) é o único com duas letras. */\nconst UCUM_PREFIXES = new Set([\n  'Y',\n  'Z',\n  'E',\n  'P',\n  'T',\n  'G',\n  'M',\n  'k',\n  'h',\n  'da',\n  'd',\n  'c',\n  'm',\n  'u',\n  'n',\n  'p',\n  'f',\n  'a',\n  'z',\n  'y',\n]);\n\n/**\n * Um átomo com prefixo opcional: `g`, `mg`, `[IU]`, `u[IU]`, `10*3`, `%`.\n *\n * O prefixo só vale na frente de átomo métrico, e o UCUM marca essa\n * propriedade átomo a átomo. Aqui a regra é mais frouxa, prefixo na frente de\n * qualquer átomo, porque o que se quer pegar é grafia que não é UCUM de jeito\n * nenhum, e não o caso de borda `kdeg`.\n */\nfunction isUcumAtom(token: string): boolean {\n  if (token === '%' || /^10\\*-?\\d+$/.test(token) || /^\\d+$/.test(token)) return true;\n  // Átomo entre colchetes: `[IU]`, `[HPF]`, `[lb_av]`, `[pH]`. Com prefixo:\n  // `u[IU]`, `m[IU]`, `k[IU]`.\n  const bracket = /^([A-Za-z]{0,2})\\[[^[\\]{}\\s]+\\]$/.exec(token);\n  if (bracket) return bracket[1] === '' || UCUM_PREFIXES.has(bracket[1] as string);\n  if (UCUM_ATOMS.has(token)) return true;\n  for (const prefix of UCUM_PREFIXES) {\n    if (token.startsWith(prefix) && UCUM_ATOMS.has(token.slice(prefix.length))) return true;\n  }\n  return false;\n}\n\n/**\n * Um componente: átomo com expoente opcional e anotação opcional, ou anotação\n * sozinha. `m2`, `cm3`, `[in_i]3`, `mL{total}`, `{ratio}`.\n *\n * A anotação aceita qualquer caractere que não seja chave, que é o que a\n * especificação diz dela: texto sem interpretação. `{specific gravity}` passa\n * por isso, mesmo com espaço.\n */\nfunction isUcumComponent(token: string): boolean {\n  const m = /^(.*?)(\\{[^{}]*\\})?$/.exec(token);\n  if (!m) return false;\n  const [, body, annotation] = m;\n  if (!body) return annotation !== undefined;\n  const exp = /^(.+?)([+-]?\\d+)?$/.exec(body as string);\n  if (!exp) return false;\n  const [, atom, exponent] = exp;\n  // `10*3` termina em dígito e não tem expoente; o regex ganancioso já\n  // separou errado, então tenta o token inteiro como átomo primeiro.\n  if (isUcumAtom(body as string)) return true;\n  if (exponent === undefined) return false;\n  return isUcumAtom(atom as string);\n}\n\n/**\n * Diz se a string é sintaticamente UCUM: componentes ligados por `.` e `/`,\n * com `/` inicial permitido (`/[HPF]`).\n *\n * É sintaxe, não semântica: `K/uL` passa porque `K` é kelvin, e nada aqui sabe\n * que o laudo quis dizer milhares. É o que `resolveUcum` e `BIOMARKER_UNITS`\n * resolvem antes de a string chegar aqui. O que este check pega é o resto:\n * grafia em português, `µ` fora do ASCII, `IU` sem colchetes, `hr`.\n *\n * O `.` e o `/` só separam fora de chaves e colchetes: `mL/min/{1.73_m2}` tem\n * um ponto dentro da anotação, e `[in_i]` poderia ter um operador dentro do\n * átomo.\n */\nexport function isUcumCode(code: string): boolean {\n  if (!code || /[^\\x21-\\x7E ]/.test(code)) return false;\n  const terms: string[] = [];\n  let current = '';\n  let braces = 0;\n  let inBracket = false;\n  for (const ch of code) {\n    if (ch === '{') braces++;\n    else if (ch === '}') {\n      if (braces === 0) return false;\n      braces--;\n    } else if (ch === '[') inBracket = true;\n    else if (ch === ']') inBracket = false;\n    if ((ch === '.' || ch === '/') && braces === 0 && !inBracket) {\n      terms.push(current, ch);\n      current = '';\n      continue;\n    }\n    current += ch;\n  }\n  if (braces !== 0 || inBracket) return false;\n  terms.push(current);\n  // `/[HPF]` é `1/[HPF]` com o numerador implícito.\n  if (terms[0] === '' && terms[1] === '/') terms[0] = '1';\n\n  let expectOperand = true;\n  for (const t of terms) {\n    if (expectOperand) {\n      if (!isUcumComponent(t)) return false;\n    } else if (t !== '.' && t !== '/') {\n      return false;\n    }\n    expectOperand = !expectOperand;\n  }\n  return !expectOperand;\n}\n\n// ─── Biomarker Unit Configurations ───────────────────────────────────────────\n\n/** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */\n\nexport interface BiomarkerUnitConfig {\n  aliases: Record<string, string>;\n  canonicalUcum: string;\n  canonicalUnit: string;\n  molecularWeight?: number;\n  siUcum: string;\n  siUnit: string;\n}\n\nconst CBC_DIFF_ALIASES: Record<string, string> = {\n  '/ul': '/uL',\n  '/µl': '/uL',\n  '10*3/ul': 'K/uL',\n  'cells/ul': '/uL',\n  'cells/µl': '/uL',\n  'k/ul': 'K/uL',\n  'x10e3/ul': 'K/uL',\n};\nconst CBC_DIFF: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '10*3/uL',\n  canonicalUnit: 'K/uL',\n  siUcum: '10*3/uL',\n  siUnit: 'K/uL',\n};\nconst DEXA_KG_ALIASES: Record<string, string> = {\n  kg: 'kg',\n  lb: '[lb_av]',\n  lbs: '[lb_av]',\n};\nconst DEXA_KG: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'kg',\n  canonicalUnit: 'kg',\n  siUcum: 'kg',\n  siUnit: 'kg',\n};\n\n/**\n * Urine sediment units — Brazilian automated analyzers (Sysmex UF-series)\n * report in /mL while manual microscopy uses /HPF. Canonical unit is /HPF.\n */\nconst URINE_SEDIMENT_ALIASES: Record<string, string> = {\n  '/hpf': '/HPF',\n  '/ml': '/mL',\n};\nconst URINE_SEDIMENT: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '/[HPF]',\n  canonicalUnit: '/HPF',\n  siUcum: '/[HPF]',\n  siUnit: '/HPF',\n};\n\n/** Percentage biomarkers — canonical and SI both use %. */\nconst PERCENTAGE_ALIASES: Record<string, string> = { '%': '%', pct: '%', percent: '%' };\nconst PERCENTAGE: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '%',\n  canonicalUnit: '%',\n  siUcum: '%',\n  siUnit: '%',\n};\n\n/** Enzyme activity — canonical and SI both use U/L. */\nconst ENZYME_ALIASES: Record<string, string> = { 'iu/l': 'U/L', 'u/l': 'U/L' };\nconst ENZYME: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'U/L',\n  canonicalUnit: 'U/L',\n  siUcum: 'U/L',\n  siUnit: 'U/L',\n};\n\n/** Monovalent electrolytes — mEq/L ↔ mmol/L (1:1). */\nconst ELECTROLYTE_MONO_ALIASES: Record<string, string> = { 'meq/l': 'mEq/L', 'mmol/l': 'mmol/L' };\nconst ELECTROLYTE_MONO: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'meq/L',\n  canonicalUnit: 'mEq/L',\n  siUcum: 'mmol/L',\n  siUnit: 'mmol/L',\n};\n\n/** CAC scores — Agatston Units (AU), dimensionless. */\nconst CAC_ALIASES: Record<string, string> = { au: 'AU' };\nconst CAC: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '{score}',\n  canonicalUnit: 'AU',\n  siUcum: '{score}',\n  siUnit: 'AU',\n};\n\n/** nmol/L biomarkers — same unit for canonical and SI. */\nconst NMOL_L_ALIASES: Record<string, string> = { 'nmol/l': 'nmol/L' };\nconst NMOL_L: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'nmol/L',\n  canonicalUnit: 'nmol/L',\n  siUcum: 'nmol/L',\n  siUnit: 'nmol/L',\n};\n\nexport const BIOMARKER_UNITS: Record<string, BiomarkerUnitConfig> = {\n  AFP: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Albumin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  AlkalinePhosphatase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  ALT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AMH: {\n    aliases: { 'ng/ml': 'ng/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 12_500,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Amylase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AntiThyroglobulin: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AntiTPO: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AoA1: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AorticValveCalcium: { aliases: CAC_ALIASES, ...CAC },\n  ApoB: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AST: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Basophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  BilirubinDirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinIndirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinTotal: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  BMI: {\n    aliases: { 'kg/m2': 'kg/m²', 'kg/m²': 'kg/m²' },\n    canonicalUcum: 'kg/m2',\n    canonicalUnit: 'kg/m²',\n    siUcum: 'kg/m2',\n    siUnit: 'kg/m²',\n  },\n  BNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  // O BUN em mmol/L é expresso como ureia: cada molécula de ureia tem dois\n  // nitrogênios, então a massa que entra na conversão é a de N2 (2 × 14,007),\n  // e não a da ureia (60,06) usada em `Urea`. 14 mg/dL de BUN ≈ 5 mmol/L.\n  BUN: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 28.0134,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CA125: {\n    aliases: { 'u/ml': 'U/mL' },\n    canonicalUcum: 'U/mL',\n    canonicalUnit: 'U/mL',\n    siUcum: 'U/mL',\n    siUnit: 'U/mL',\n  },\n  CAC_LAD: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LCX: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LMA: { aliases: CAC_ALIASES, ...CAC },\n  CAC_RCA: { aliases: CAC_ALIASES, ...CAC },\n  Calcium: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 40.08,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CEA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Chloride: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CK: { aliases: ENZYME_ALIASES, ...ENZYME },\n  CO2: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cortisol: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 362.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Creatinine: {\n    aliases: { 'mg/dl': 'mg/dL', 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 113.12,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  CRP: {\n    aliases: { 'mg/dl': 'mg/dL', 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  DHEAS: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 368.49,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  DHT: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 290.44,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  eGFR: {\n    aliases: {\n      'ml/min/1,73 m2': 'mL/min/1.73m²',\n      'ml/min/1.73m2': 'mL/min/1.73m²',\n      'ml/min/1.73m²': 'mL/min/1.73m²',\n    },\n    canonicalUcum: 'mL/min/{1.73_m2}',\n    canonicalUnit: 'mL/min/1.73m²',\n    siUcum: 'mL/min/{1.73_m2}',\n    siUnit: 'mL/min/1.73m²',\n  },\n  Eosinophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  EPADPADHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  ESR: {\n    aliases: { 'mm/h': 'mm/h', 'mm/hr': 'mm/h' },\n    canonicalUcum: 'mm/h',\n    canonicalUnit: 'mm/h',\n    siUcum: 'mm/h',\n    siUnit: 'mm/h',\n  },\n  Estradiol: {\n    aliases: { 'ng/dl': 'ng/dL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 272.38,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Ferritin: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  Folate: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 441.4,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  FSH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'm[iU]/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  GGT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Globulin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Glucose: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 180.156,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HbA1c: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Hct: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  HDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HDL_Large: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Hgb: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Homocysteine: {\n    aliases: { 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'umol/L',\n    canonicalUnit: 'µmol/L',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  // Imunoglobulinas: canônica em mg/dL, a unidade da faixa de referência\n  // (Tietz) e a que laboratórios brasileiros e americanos imprimem. g/L fica\n  // como unidade SI; a conversão é exata (g/L × 100 = mg/dL, em FIXED_FACTORS).\n  IgA: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  IgG: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  INR: {\n    aliases: { '{ratio}': '{ratio}' },\n    canonicalUcum: '{ratio}',\n    canonicalUnit: '{ratio}',\n    siUcum: '{ratio}',\n    siUnit: '{ratio}',\n  },\n  Insulin: {\n    aliases: {\n      'mu/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Iron: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  LDL_Medium: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_ParticleNumber: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_Peak_Size: {\n    aliases: { å: 'Ao', angstrom: 'Ao', ao: 'Ao', nm: 'nm' },\n    canonicalUcum: 'Ao',\n    canonicalUnit: 'Angstrom',\n    siUcum: 'nm',\n    siUnit: 'nm',\n  },\n  LDL_Small: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Lead: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 207.2,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Leptin: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  LH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'm[iU]/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Lipase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Lipoprotein_a: {\n    aliases: { 'mg/dl': 'mg/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'nmol/L',\n    canonicalUnit: 'nmol/L',\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Lymphocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MCH: {\n    aliases: { pg: 'pg' },\n    canonicalUcum: 'pg',\n    canonicalUnit: 'pg',\n    siUcum: 'pg',\n    siUnit: 'pg',\n  },\n  MCHC: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  MCV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Mercury: {\n    aliases: { 'mcg/l': 'µg/L', 'nmol/l': 'nmol/L', 'ug/l': 'µg/L', 'µg/l': 'µg/L' },\n    canonicalUcum: 'ug/L',\n    canonicalUnit: 'µg/L',\n    molecularWeight: 200.59,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Microalbumin_Urine: {\n    aliases: { 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  MMA: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Monocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MPV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Myeloperoxidase: {\n    aliases: { 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pmol/L',\n    canonicalUnit: 'pmol/L',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Neutrophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  // MW 386.65 = colesterol livre. Frações lipoproteicas são heterogêneas,\n  // mas a conversão mg/dL→mmol/L usa MW do colesterol por convenção clínica.\n  NonHDL_Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  NTproBNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  Omega3_DHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_DPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_EPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_AA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_LA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Potassium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Progesterone: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 314.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Prolactin: {\n    aliases: {\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  ProthrombinTime: {\n    aliases: { s: 's', sec: 's' },\n    canonicalUcum: 's',\n    canonicalUnit: 's',\n    siUcum: 's',\n    siUnit: 's',\n  },\n  PSA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  PSA_Free: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  RBC: {\n    aliases: {\n      '/ul': '/uL',\n      '/µl': '/uL',\n      '10*6/ul': 'M/uL',\n      'cells/ul': '/uL',\n      'm/ul': 'M/uL',\n      'milhões/mm3': 'M/uL',\n      'milhões/mm³': 'M/uL',\n      'x10e6/ul': 'M/uL',\n    },\n    canonicalUcum: '10*6/uL',\n    canonicalUnit: 'M/uL',\n    siUcum: '10*6/uL',\n    siUnit: 'M/uL',\n  },\n  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  RDW: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Reticulocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  RheumatoidFactor: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  SHBG: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Sodium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  T3Free: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 650.98,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T3Total: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 650.98,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  T4Free: {\n    aliases: { 'ng/dl': 'ng/dL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 776.87,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T4Total: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 776.87,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Testosterone: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 288.42,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  TestosteroneFree: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 288.42,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  TIBC: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  TotalProtein: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Triglycerides: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 885.4,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  TroponinI: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  // Troponina T: canônica em ng/L (hs-cTnT). O ensaio convencional imprime em\n  // ng/mL, que é a mesma grandeza que µg/L; converte por fator exato\n  // (ng/mL × 1000 = ng/L, em FIXED_FACTORS). pg/mL é a mesma unidade que ng/L\n  // e entra como alias, como em VitaminB12.\n  TroponinT: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/l': 'ng/L',\n      'ng/ml': 'ng/mL',\n      'pg/ml': 'ng/L',\n      'ug/l': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/L',\n    canonicalUnit: 'ng/L',\n    siUcum: 'ng/L',\n    siUnit: 'ng/L',\n  },\n  TSH: {\n    aliases: {\n      'miu/l': 'uIU/mL',\n      'mui/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'm[iU]/L',\n    siUnit: 'mIU/L',\n  },\n  Urea: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 60.06,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  UricAcid: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 168.11,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  VATVolume: {\n    aliases: { cm3: 'cm3', 'cm³': 'cm3', in3: '[in_i]3', 'in³': '[in_i]3' },\n    canonicalUcum: 'cm3',\n    canonicalUnit: 'cm³',\n    siUcum: 'cm3',\n    siUnit: 'cm³',\n  },\n  VitaminB12: {\n    aliases: { 'ng/l': 'pg/mL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  VitaminD: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 384.64,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  VLDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n};\n\n/**\n * Get the canonical unit for a biomarker code.\n */\nexport function getCanonicalUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;\n}\n\n/**\n * Get the SI unit for a biomarker code.\n */\nexport function getSIUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.siUnit ?? null;\n}\n\n// ─── Unit Conversion ────────────────────────────────────────────────────────────\n\n/**\n * Normalize a unit string to its canonical display form for a given biomarker.\n * Returns the input unchanged if no alias is found.\n */\nfunction normalizeUnit(unit: string, config: BiomarkerUnitConfig): string {\n  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;\n}\n\n/**\n * Conversion factor tables for unit pairs that don't require molecular weight.\n * Key format: \"fromUnit -> toUnit\" (using canonical display forms).\n * Both directions must be listed explicitly — there is no auto-inversion.\n */\nconst FIXED_FACTORS: Record<string, number> = {\n  'g/dL -> g/L': 10,\n  'g/L -> g/dL': 0.1,\n  'g/L -> mg/dL': 100,\n  'mEq/L -> mmol/L': 1,\n  'mg/dL -> g/L': 0.01,\n  'mmol/L -> mEq/L': 1,\n  'ng/dL -> pg/mL': 10,\n  'ng/L -> ng/mL': 0.001,\n  'ng/mL -> ng/L': 1000,\n  'ng/mL -> µg/L': 1,\n  'pg/mL -> ng/dL': 0.1,\n  'µg/L -> ng/mL': 1,\n};\n\n/**\n * MW-based conversion definitions.\n * Each entry maps a (fromUnit, toUnit) pair to the formula:\n *   result = value × numerator / (MW × denominator)\n *\n * Common patterns:\n *   mg/dL  → mmol/L:  value × 10   / MW\n *   mg/dL  → µmol/L:  value × 10000 / MW  (or equivalently × 10 / MW × 1000)\n *   ng/mL  → nmol/L:  value × 1000 / MW\n *   pg/mL  → pmol/L:  value × 1000 / MW\n *   ng/dL  → nmol/L:  value × 10   / MW\n */\n/**\n * MW conversion entries. Each direction is explicit to avoid fragile inversion logic.\n * Formula: result = value × scale / MW  (when divideByMW is true)\n *          result = value × MW / scale  (when divideByMW is false)\n */\ninterface MWConversion {\n  divideByMW: boolean;\n  scale: number;\n}\n\nconst MW_CONVERSIONS: Record<string, MWConversion> = {\n  'mg/dL -> mmol/L': { divideByMW: true, scale: 10 },\n  'mg/dL -> µmol/L': { divideByMW: true, scale: 10_000 },\n  'mmol/L -> mg/dL': { divideByMW: false, scale: 10 },\n  'ng/dL -> nmol/L': { divideByMW: true, scale: 10 },\n  'ng/dL -> pmol/L': { divideByMW: true, scale: 10_000 },\n  'ng/mL -> nmol/L': { divideByMW: true, scale: 1000 },\n  'ng/mL -> pmol/L': { divideByMW: true, scale: 1_000_000 },\n  'nmol/L -> ng/dL': { divideByMW: false, scale: 10 },\n  'nmol/L -> ng/mL': { divideByMW: false, scale: 1000 },\n  'nmol/L -> µg/dL': { divideByMW: false, scale: 10_000 },\n  'nmol/L -> µg/L': { divideByMW: false, scale: 1000 },\n  'pg/mL -> pmol/L': { divideByMW: true, scale: 1000 },\n  'pmol/L -> ng/dL': { divideByMW: false, scale: 10_000 },\n  'pmol/L -> ng/mL': { divideByMW: false, scale: 1_000_000 },\n  'pmol/L -> pg/mL': { divideByMW: false, scale: 1000 },\n  'µg/dL -> nmol/L': { divideByMW: true, scale: 10_000 },\n  'µg/dL -> µmol/L': { divideByMW: true, scale: 10 },\n  'µg/L -> nmol/L': { divideByMW: true, scale: 1000 },\n  'µmol/L -> mg/dL': { divideByMW: false, scale: 10_000 },\n  'µmol/L -> µg/dL': { divideByMW: false, scale: 10 },\n};\n\nexport interface ConversionResult {\n  unit: string;\n  value: number;\n}\n\n/**\n * Convert a biomarker value between units.\n *\n * Supports:\n * - Fixed-factor conversions (e.g. ng/dL ↔ pg/mL, g/dL ↔ g/L)\n * - Molecular-weight-based conversions (e.g. mg/dL ↔ mmol/L, pg/mL ↔ pmol/L)\n *\n * @returns The converted value and target unit, or null if conversion is not possible.\n */\nexport function convertUnit(\n  value: number,\n  fromUnit: string,\n  toUnit: string,\n  biomarkerCode: string,\n): ConversionResult | null {\n  const config = BIOMARKER_UNITS[biomarkerCode];\n  if (!config) return null;\n\n  const normFrom = normalizeUnit(fromUnit, config);\n  const normTo = normalizeUnit(toUnit, config);\n\n  if (normFrom === normTo) {\n    return { unit: normTo, value };\n  }\n\n  const key = `${normFrom} -> ${normTo}`;\n\n  const fixedFactor = FIXED_FACTORS[key];\n  if (fixedFactor !== undefined) {\n    return { unit: normTo, value: value * fixedFactor };\n  }\n\n  const mwConv = MW_CONVERSIONS[key];\n  if (mwConv && config.molecularWeight) {\n    const result = mwConv.divideByMW\n      ? (value * mwConv.scale) / config.molecularWeight\n      : (value * config.molecularWeight) / mwConv.scale;\n    return { unit: normTo, value: result };\n  }\n\n  return null;\n}\n\n/**\n * Código UCUM para a unidade que o laudo imprimiu, ou `undefined`.\n *\n * Ordem: a configuração do biomarcador em `BIOMARKER_UNITS` (que já sabe que\n * `K/uL` de leucócito é `10*3/uL`), depois a tabela `UNIT_TO_UCUM`, e por\n * último a própria string, se for UCUM sintaticamente válido. Fora disso é\n * `undefined`, e o conversor deixa o `Quantity` só com `unit`: unidade que\n * não se sabe traduzir não sai sob `http://unitsofmeasure.org`.\n *\n * Até out/2026 o conversor só consultava a tabela e devolvia a entrada\n * intacta quando não achava, então `uIU/mL`, `K/uL` e `razão` saíam como\n * código UCUM, e os 85 `canonicalUcum` de `BIOMARKER_UNITS` não eram lidos\n * por ninguém fora de `units.ts`.\n */\nexport function resolveUcum(unit: string, biomarkerCode?: string): string | undefined {\n  if (!unit) return undefined;\n  const config = biomarkerCode ? BIOMARKER_UNITS[biomarkerCode] : undefined;\n  if (config) {\n    const normalized = normalizeUnit(unit, config);\n    if (normalized === config.canonicalUnit) return config.canonicalUcum;\n    if (normalized === config.siUnit) return config.siUcum;\n  }\n  const mapped = UNIT_TO_UCUM[unit];\n  if (mapped) return mapped;\n  return isUcumCode(unit) ? unit : undefined;\n}\n"]}

package/dist/{chunk-AJUDODBT.cjs → chunk-LUGMRMWY.cjs}

@@ -1,6 +1,6 @@
 "use strict";Object.defineProperty(exports, "__esModule", {value: true}); function _nullishCoalesce(lhs, rhsFn) { if (lhs != null) { return lhs; } else { return rhsFn(); } } function _optionalChain(ops) { let lastAccessLHS = undefined; let value = ops[0]; let i = 1; while (i < ops.length) { const op = ops[i]; const fn = ops[i + 1]; i += 2; if ((op === 'optionalAccess' || op === 'optionalCall') && value == null) { return undefined; } if (op === 'access' || op === 'optionalAccess') { lastAccessLHS = value; value = fn(value); } else if (op === 'call' || op === 'optionalCall') { value = fn((...args) => value.call(lastAccessLHS, ...args)); lastAccessLHS = undefined; } } return value; }
 
-var _chunkLSC7NHFEcjs = require('./chunk-LSC7NHFE.cjs');
+var _chunkNUFN24W4cjs = require('./chunk-NUFN24W4.cjs');
 
 
 
@@ -12,7 +12,7 @@ var _chunkOR67NJDZcjs = require('./chunk-OR67NJDZ.cjs');
 
 
 
-var _chunkBDS6CM7Fcjs = require('./chunk-BDS6CM7F.cjs');
+var _chunkVMID6CDCcjs = require('./chunk-VMID6CDC.cjs');
 
 // src/importer.ts
 var MAX_OBSERVATIONS = 5e3;
@@ -34,11 +34,11 @@ function resolveBiomarkerCode(observation) {
   } else {
     reason = "No code found in observation coding";
   }
-  const fromLoinc = loincCode ? _chunkBDS6CM7Fcjs.loincToCode.call(void 0, loincCode) : void 0;
+  const fromLoinc = loincCode ? _chunkVMID6CDCcjs.loincToCode.call(void 0, loincCode) : void 0;
   if (fromLoinc) return { internalCode: fromLoinc, loincCode, reason };
-  if (declaredCode && _chunkBDS6CM7Fcjs.isValidCode.call(void 0, declaredCode)) {
-    const canonical = _chunkBDS6CM7Fcjs.normalizeCode.call(void 0, declaredCode);
-    return { internalCode: canonical, loincCode: _chunkBDS6CM7Fcjs.codeToLoinc.call(void 0, canonical), reason };
+  if (declaredCode && _chunkVMID6CDCcjs.isValidCode.call(void 0, declaredCode)) {
+    const canonical = _chunkVMID6CDCcjs.normalizeCode.call(void 0, declaredCode);
+    return { internalCode: canonical, loincCode: _chunkVMID6CDCcjs.codeToLoinc.call(void 0, canonical), reason };
   }
   return { loincCode, reason };
 }
@@ -75,7 +75,7 @@ function mapFHIRObservationToInternal(observation, index) {
       skipped: { index, loincCode, reason, resourceType: "Observation" }
     };
   }
-  const definition = _chunkBDS6CM7Fcjs.getDefinitionByCode.call(void 0, internalCode);
+  const definition = _chunkVMID6CDCcjs.getDefinitionByCode.call(void 0, internalCode);
   let value;
   let unit = "";
   let isQualitative = false;
@@ -125,7 +125,7 @@ function mapFHIRObservationToInternal(observation, index) {
     flag: extractFlag(observation),
     isQualitative,
     loincCode,
-    ...loincCode && _chunkBDS6CM7Fcjs.methodVariantOf.call(void 0, internalCode, loincCode) && { methodLoinc: loincCode },
+    ...loincCode && _chunkVMID6CDCcjs.methodVariantOf.call(void 0, internalCode, loincCode) && { methodLoinc: loincCode },
     ...referenceKind && { referenceKind },
     referenceMax,
     referenceMin,
@@ -135,7 +135,7 @@ function mapFHIRObservationToInternal(observation, index) {
   return { observation: imported };
 }
 function processImportBundle(data) {
-  const validationErrors = _chunkLSC7NHFEcjs.validateFHIRImportBundle.call(void 0, data);
+  const validationErrors = _chunkNUFN24W4cjs.validateFHIRImportBundle.call(void 0, data);
   if (validationErrors.length > 0) {
     return {
       errors: validationErrors,
@@ -171,4 +171,4 @@ function processImportBundle(data) {
 
 
 exports.MAX_OBSERVATIONS = MAX_OBSERVATIONS; exports.MAX_FILE_SIZE = MAX_FILE_SIZE; exports.extractObservationsFromBundle = extractObservationsFromBundle; exports.mapFHIRObservationToInternal = mapFHIRObservationToInternal; exports.processImportBundle = processImportBundle;
-//# sourceMappingURL=chunk-AJUDODBT.cjs.map
+//# sourceMappingURL=chunk-LUGMRMWY.cjs.map

package/dist/{chunk-AJUDODBT.cjs.map → chunk-LUGMRMWY.cjs.map}

@@ -1 +1 @@
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Nesse tamanho, 5000 Observations dão 6,0MB\n * compactos ou 13,1MB indentados, e por isso o teto de arquivo é 15MB: cobre\n * as duas formas com folga.\n *\n * Na densidade desse mesmo histórico (16 Observations por laudo), 5000\n * equivalem a cerca de 300 laudos.\n */\nconst MAX_OBSERVATIONS = 5000;\nconst MAX_FILE_SIZE = 15 * 1024 * 1024; // 15MB\n\n/**\n * Resolve o código interno do biomarcador a partir do `code.coding`.\n *\n * LOINC primeiro, que é o vocabulário que arquivos de terceiros usam. Quando\n * não resolve, cai para o coding de códigos internos, presente nos arquivos\n * exportados pela própria plataforma.\n *\n * O fallback cobre dois casos: biomarcadores sem LOINC publicado (composição\n * corporal, densidade óssea, escore de cálcio) e arquivos antigos, exportados\n * quando esses biomarcadores saíam com o placeholder `99999-9`, que não\n * resolve para nada.\n */\nfunction resolveBiomarkerCode(observation: FHIRObservation): {\n  internalCode?: string;\n  loincCode?: string;\n  reason: string;\n} {\n  const coding = observation.code?.coding ?? [];\n  const loincCode = coding.find((c) => c.system === LOINC_SYSTEM)?.code;\n  const declaredCode = coding.find((c) => c.system === BIOMARKER_CODE_SYSTEM)?.code;\n\n  const seenCodes = [\n    ...(loincCode ? [`LOINC ${loincCode}`] : []),\n    ...(declaredCode ? [`biomarker code ${declaredCode}`] : []),\n  ];\n\n  // Três motivos distintos de descarte, que antes se confundiam num só. Sem\n  // essa separação, um arquivo em SNOMED relatava \"nenhum código encontrado\",\n  // sugerindo `coding` vazio quando na verdade o código existia e estava num\n  // system que não tratamos. Para importação de terceiros, é a diferença entre\n  // um diagnóstico acionável e um enigma.\n  let reason: string;\n  if (seenCodes.length > 0) {\n    reason = `Unknown code: ${seenCodes.join(', ')}`;\n  } else if (coding.length > 0) {\n    const systems = [...new Set(coding.map((c) => c.system ?? '(sem system)'))];\n    reason = `No code in a supported system (found: ${systems.join(', ')})`;\n  } else {\n    reason = 'No code found in observation coding';\n  }\n\n  const fromLoinc = loincCode ? loincToCode(loincCode) : undefined;\n  if (fromLoinc) return { internalCode: fromLoinc, loincCode, reason };\n\n  if (declaredCode && isValidCode(declaredCode)) {\n    // `isValidCode` aceita alias, mas alias não serve como código armazenado:\n    // 49 definições têm um, e tanto `codeToLoinc` quanto as faixas de\n    // referência são indexadas só pelo canônico. Sem normalizar, `VLDL_Cholesterol`\n    // entraria no lugar de `VLDL` e perderia o LOINC 13458-5 que ele tem.\n    // Importar um Bundle é fronteira de dados, que é onde `normalizeCode` deve\n    // ser aplicado.\n    const canonical = normalizeCode(declaredCode);\n\n    // `codeToLoinc` devolve undefined para quem não tem LOINC, que é o caso\n    // esperado aqui. 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Nesse tamanho, 5000 Observations dão 6,0MB\n * compactos ou 13,1MB indentados, e por isso o teto de arquivo é 15MB: cobre\n * as duas formas com folga.\n *\n * Na densidade desse mesmo histórico (16 Observations por laudo), 5000\n * equivalem a cerca de 300 laudos.\n */\nconst MAX_OBSERVATIONS = 5000;\nconst MAX_FILE_SIZE = 15 * 1024 * 1024; // 15MB\n\n/**\n * Resolve o código interno do biomarcador a partir do `code.coding`.\n *\n * LOINC primeiro, que é o vocabulário que arquivos de terceiros usam. Quando\n * não resolve, cai para o coding de códigos internos, presente nos arquivos\n * exportados pela própria plataforma.\n *\n * O fallback cobre dois casos: biomarcadores sem LOINC publicado (composição\n * corporal, densidade óssea, escore de cálcio) e arquivos antigos, exportados\n * quando esses biomarcadores saíam com o placeholder `99999-9`, que não\n * resolve para nada.\n */\nfunction resolveBiomarkerCode(observation: FHIRObservation): {\n  internalCode?: string;\n  loincCode?: string;\n  reason: string;\n} {\n  const coding = observation.code?.coding ?? [];\n  const loincCode = coding.find((c) => c.system === LOINC_SYSTEM)?.code;\n  const declaredCode = coding.find((c) => c.system === BIOMARKER_CODE_SYSTEM)?.code;\n\n  const seenCodes = [\n    ...(loincCode ? [`LOINC ${loincCode}`] : []),\n    ...(declaredCode ? [`biomarker code ${declaredCode}`] : []),\n  ];\n\n  // Três motivos distintos de descarte, que antes se confundiam num só. Sem\n  // essa separação, um arquivo em SNOMED relatava \"nenhum código encontrado\",\n  // sugerindo `coding` vazio quando na verdade o código existia e estava num\n  // system que não tratamos. Para importação de terceiros, é a diferença entre\n  // um diagnóstico acionável e um enigma.\n  let reason: string;\n  if (seenCodes.length > 0) {\n    reason = `Unknown code: ${seenCodes.join(', ')}`;\n  } else if (coding.length > 0) {\n    const systems = [...new Set(coding.map((c) => c.system ?? '(sem system)'))];\n    reason = `No code in a supported system (found: ${systems.join(', ')})`;\n  } else {\n    reason = 'No code found in observation coding';\n  }\n\n  const fromLoinc = loincCode ? loincToCode(loincCode) : undefined;\n  if (fromLoinc) return { internalCode: fromLoinc, loincCode, reason };\n\n  if (declaredCode && isValidCode(declaredCode)) {\n    // `isValidCode` aceita alias, mas alias não serve como código armazenado:\n    // 49 definições têm um, e tanto `codeToLoinc` quanto as faixas de\n    // referência são indexadas só pelo canônico. Sem normalizar, `VLDL_Cholesterol`\n    // entraria no lugar de `VLDL` e perderia o LOINC 13458-5 que ele tem.\n    // Importar um Bundle é fronteira de dados, que é onde `normalizeCode` deve\n    // ser aplicado.\n    const canonical = normalizeCode(declaredCode);\n\n    // `codeToLoinc` devolve undefined para quem não tem LOINC, que é o caso\n    // esperado aqui. O campo fica de fora em vez de receber um valor inventado.\n    return { internalCode: canonical, loincCode: codeToLoinc(canonical), reason };\n  }\n\n  return { loincCode, reason };\n}\n\n/**\n * Extract interpretation flag from Observation\n */\nfunction extractFlag(observation: FHIRObservation): 'H' | 'L' | '' {\n  const code = observation.interpretation?.[0]?.coding?.[0]?.code;\n  if (code === 'H' || code === 'HH') return 'H';\n  if (code === 'L' || code === 'LL') return 'L';\n  return '';\n}\n\n/**\n * Extract Observation resources from a FHIR Bundle\n */\nexport function extractObservationsFromBundle(bundle: FHIRBundle): {\n  observations: FHIRObservation[];\n  skipped: SkippedEntry[];\n} {\n  const observations: FHIRObservation[] = [];\n  const skipped: SkippedEntry[] = [];\n\n  for (let i = 0; i < bundle.entry.length; i++) {\n    const entry = bundle.entry[i]!;\n    if (!entry.resource) {\n      skipped.push({ index: i, reason: 'Entry has no resource' });\n      continue;\n    }\n\n    if (entry.resource.resourceType !== 'Observation') {\n      // Non-observation resources are silently skipped (Patient, DiagnosticReport, etc.)\n      continue;\n    }\n\n    if (observations.length >= MAX_OBSERVATIONS) {\n      skipped.push({ index: i, reason: `Maximum of ${MAX_OBSERVATIONS} observations exceeded` });\n      continue;\n    }\n\n    observations.push(entry.resource as FHIRObservation);\n  }\n\n  return { observations, skipped };\n}\n\n/**\n * Map a FHIR Observation to internal format using LOINC→biomarker code lookup\n */\nexport function mapFHIRObservationToInternal(\n  observation: FHIRObservation,\n  index: number,\n): { observation: ImportedObservation } | { skipped: SkippedEntry } {\n  const { internalCode, loincCode, reason } = resolveBiomarkerCode(observation);\n\n  if (!internalCode) {\n    return {\n      skipped: { index, loincCode, reason, resourceType: 'Observation' },\n    };\n  }\n\n  const definition = getDefinitionByCode(internalCode);\n\n  // Extract value\n  let value: number | string;\n  let unit = '';\n  let isQualitative = false;\n\n  if (observation.valueQuantity?.value !== undefined) {\n    value = observation.valueQuantity.value;\n    unit = observation.valueQuantity.unit || observation.valueQuantity.code || '';\n  } else if (observation.valueString) {\n    value = observation.valueString;\n    isQualitative = true;\n  } else {\n    return {\n      skipped: {\n        index,\n        loincCode,\n        reason: 'Observation has no value (valueQuantity or valueString)',\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  // Extract collection date (effectiveDateTime or effectivePeriod.start)\n  const collectionDate = observation.effectiveDateTime || observation.effectivePeriod?.start || '';\n  if (!collectionDate) {\n    return {\n      skipped: {\n        index,\n        loincCode,\n        reason: 'Observation has no effectiveDateTime or effectivePeriod.start',\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  // Extract reference ranges\n  let referenceMin: number | undefined;\n  let referenceMax: number | undefined;\n  let referenceKind: ImportedObservation['referenceKind'];\n  if (observation.referenceRange?.[0]) {\n    referenceMin = observation.referenceRange[0].low?.value;\n    referenceMax = observation.referenceRange[0].high?.value;\n    const meaning = observation.referenceRange[0].type?.coding?.find(\n      (c) => c.system === 'http://terminology.hl7.org/CodeSystem/referencerange-meaning',\n    )?.code;\n    if (meaning === 'normal') referenceKind = 'reference-interval';\n    else if (meaning === 'recommended') referenceKind = 'decision-threshold';\n  }\n\n  const imported: ImportedObservation = {\n    biomarkerCode: internalCode,\n    biomarkerName:\n      definition?.names.pt[0] || definition?.names.en[0] || observation.code.text || internalCode,\n    collectionDate,\n    flag: extractFlag(observation),\n    isQualitative,\n    loincCode,\n    ...(loincCode && methodVariantOf(internalCode, loincCode) && { methodLoinc: loincCode }),\n    ...(referenceKind && { referenceKind }),\n    referenceMax,\n    referenceMin,\n    unit: unit || definition?.unit || '',\n    value,\n  };\n\n  return { observation: imported };\n}\n\n/**\n * Process a complete FHIR Bundle for import\n */\nexport function processImportBundle(data: unknown): FHIRImportResult {\n  // Structural validation\n  const validationErrors = validateFHIRImportBundle(data);\n  if (validationErrors.length > 0) {\n    return {\n      errors: validationErrors,\n      imported: [],\n      skipped: [],\n      totalProcessed: 0,\n    };\n  }\n\n  const bundle = data as FHIRBundle;\n\n  // Extract observations\n  const { observations, skipped } = extractObservationsFromBundle(bundle);\n\n  // Map each observation to internal format\n  const imported: ImportedObservation[] = [];\n  const allSkipped: SkippedEntry[] = [...skipped];\n\n  for (let i = 0; i < observations.length; i++) {\n    const result = mapFHIRObservationToInternal(observations[i]!, i);\n\n    if ('observation' in result) {\n      imported.push(result.observation);\n    } else {\n      allSkipped.push(result.skipped);\n    }\n  }\n\n  return {\n    errors: [],\n    imported,\n    skipped: allSkipped,\n    totalProcessed: observations.length,\n  };\n}\n\nexport { MAX_FILE_SIZE, MAX_OBSERVATIONS };\n"]}

package/dist/{chunk-LSC7NHFE.cjs → chunk-NUFN24W4.cjs}

@@ -1,13 +1,13 @@
 "use strict";Object.defineProperty(exports, "__esModule", {value: true}); function _nullishCoalesce(lhs, rhsFn) { if (lhs != null) { return lhs; } else { return rhsFn(); } }
 
-var _chunkRWUFK5ANcjs = require('./chunk-RWUFK5AN.cjs');
+var _chunkIY6BZX2Vcjs = require('./chunk-IY6BZX2V.cjs');
 
 // src/validators.ts
 var UCUM_SYSTEM = "http://unitsofmeasure.org";
 function ucumErrors(quantity, where) {
   if (!quantity || quantity.system !== UCUM_SYSTEM) return [];
   if (!quantity.code) return [`${where}: UCUM system declared without a code`];
-  if (!_chunkRWUFK5ANcjs.isUcumCode.call(void 0, quantity.code)) {
+  if (!_chunkIY6BZX2Vcjs.isUcumCode.call(void 0, quantity.code)) {
     return [`${where}: "${quantity.code}" is not a UCUM code`];
   }
   return [];
@@ -78,4 +78,4 @@ function validateFHIRImportBundle(data) {
 
 
 exports.validateFHIRDiagnosticReport = validateFHIRDiagnosticReport; exports.validateFHIRObservation = validateFHIRObservation; exports.validateFHIRImportBundle = validateFHIRImportBundle;
-//# sourceMappingURL=chunk-LSC7NHFE.cjs.map
+//# sourceMappingURL=chunk-NUFN24W4.cjs.map

package/dist/{chunk-LSC7NHFE.cjs.map → chunk-NUFN24W4.cjs.map}

@@ -1 +1 @@
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+{"version":3,"sources":["/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/chunk-NUFN24W4.cjs","../src/validators.ts"],"names":[],"mappings":"AAAA;AACE;AACF,wDAA6B;AAC7B;AACA;ACMA,IAAM,YAAA,EAAc,2BAAA;AAYpB,SAAS,UAAA,CAAW,QAAA,EAAoC,KAAA,EAAyB;AAC/E,EAAA,GAAA,CAAI,CAAC,SAAA,GAAY,QAAA,CAAS,OAAA,IAAW,WAAA,EAAa,OAAO,CAAC,CAAA;AAC1D,EAAA,GAAA,CAAI,CAAC,QAAA,CAAS,IAAA,EAAM,OAAO,CAAC,CAAA,EAAA;AACC,EAAA;AACL,IAAA;AACxB,EAAA;AACQ,EAAA;AACV;AAKgB;AACY,EAAA;AAEE,EAAA;AACd,IAAA;AACd,EAAA;AAEoB,EAAA;AACN,IAAA;AACd,EAAA;AAE4B,EAAA;AACd,IAAA;AACd,EAAA;AAEwB,EAAA;AACV,IAAA;AACd,EAAA;AAEO,EAAA;AACT;AAKgB;AACY,EAAA;AAET,EAAA;AACH,IAAA;AACd,EAAA;AAEyB,EAAA;AACX,IAAA;AACd,EAAA;AAE0B,EAAA;AACZ,IAAA;AACd,EAAA;AAE6B,EAAA;AACf,IAAA;AACd,EAAA;AAEiB,EAAA;AACH,IAAA;AACd,EAAA;AAE0B,EAAA;AACA,EAAA;AACE,IAAA;AACA,IAAA;AAC5B,EAAA;AAEO,EAAA;AACT;AAKgB;AACiB,EAAA;AAEF,EAAA;AACJ,IAAA;AAChB,IAAA;AACT,EAAA;AAEe,EAAA;AAEa,EAAA;AACd,IAAA;AACD,MAAA;AACF,MAAA;AACR,IAAA;AACH,EAAA;AAE0B,EAAA;AACD,IAAA;AACD,EAAA;AACC,IAAA;AACzB,EAAA;AAEO,EAAA;AACT;AD5C+B;AACA;AACA;AACA;AACA;AACA","file":"/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/chunk-NUFN24W4.cjs","sourcesContent":[null,"/**\n * FHIR Validators\n *\n * Validation functions for FHIR R4 resources.\n */\n\nimport type { FHIRDiagnosticReport, FHIRObservation, FHIRQuantity } from './fhir-types';\nimport type { ImportError } from './importer';\nimport { isUcumCode } from './units';\n\nconst UCUM_SYSTEM = 'http://unitsofmeasure.org';\n\n/**\n * Um `Quantity` que afirma o system do UCUM precisa de um `code` que seja\n * UCUM. Sem `code` a afirmação está vazia; com `code` que não é UCUM ela está\n * errada, e foi o caso durante meses: `uIU/mL`, `K/uL` e `razão` saíam sob\n * `http://unitsofmeasure.org` porque o conversor devolvia a grafia do laudo\n * intacta quando não a conhecia.\n *\n * `Quantity` sem `system` passa: unidade só em texto é legítima, e é o que o\n * conversor emite quando não sabe traduzir.\n */\nfunction ucumErrors(quantity: FHIRQuantity | undefined, where: string): string[] {\n  if (!quantity || quantity.system !== UCUM_SYSTEM) return [];\n  if (!quantity.code) return [`${where}: UCUM system declared without a code`];\n  if (!isUcumCode(quantity.code)) {\n    return [`${where}: \"${quantity.code}\" is not a UCUM code`];\n  }\n  return [];\n}\n\n/**\n * Validate FHIR DiagnosticReport\n */\nexport function validateFHIRDiagnosticReport(report: FHIRDiagnosticReport): string[] {\n  const errors: string[] = [];\n\n  if (!report.resourceType || report.resourceType !== 'DiagnosticReport') {\n    errors.push('Invalid resourceType');\n  }\n\n  if (!report.status) {\n    errors.push('Missing status');\n  }\n\n  if (!report.code || !report.code.coding || report.code.coding.length === 0) {\n    errors.push('Missing or invalid code');\n  }\n\n  if (!report.subject || !report.subject.reference) {\n    errors.push('Missing subject reference');\n  }\n\n  return errors;\n}\n\n/**\n * Validate FHIR Observation\n */\nexport function validateFHIRObservation(observation: FHIRObservation): string[] {\n  const errors: string[] = [];\n\n  if (!observation.resourceType || observation.resourceType !== 'Observation') {\n    errors.push('Invalid resourceType');\n  }\n\n  if (!observation.status) {\n    errors.push('Missing status');\n  }\n\n  if (!observation.code || !observation.code.coding || observation.code.coding.length === 0) {\n    errors.push('Missing or invalid code');\n  }\n\n  if (!observation.subject || !observation.subject.reference) {\n    errors.push('Missing subject reference');\n  }\n\n  if (!observation.valueQuantity && !observation.valueString) {\n    errors.push('Missing value (valueQuantity or valueString)');\n  }\n\n  errors.push(...ucumErrors(observation.valueQuantity, 'valueQuantity'));\n  for (const [i, range] of (observation.referenceRange ?? []).entries()) {\n    errors.push(...ucumErrors(range.low, `referenceRange[${i}].low`));\n    errors.push(...ucumErrors(range.high, `referenceRange[${i}].high`));\n  }\n\n  return errors;\n}\n\n/**\n * Validate that the input is a structurally valid FHIR Bundle\n */\nexport function validateFHIRImportBundle(data: unknown): ImportError[] {\n  const errors: ImportError[] = [];\n\n  if (!data || typeof data !== 'object') {\n    errors.push({ details: 'Input must be a JSON object', field: 'root' });\n    return errors;\n  }\n\n  const bundle = data as Record<string, unknown>;\n\n  if (bundle.resourceType !== 'Bundle') {\n    errors.push({\n      details: `Expected resourceType \"Bundle\", got \"${String(bundle.resourceType)}\"`,\n      field: 'resourceType',\n    });\n  }\n\n  if (!Array.isArray(bundle.entry)) {\n    errors.push({ details: 'Bundle must contain an \"entry\" array', field: 'entry' });\n  } else if (bundle.entry.length === 0) {\n    errors.push({ details: 'Bundle entry array is empty', field: 'entry' });\n  }\n\n  return errors;\n}\n"]}

package/dist/{chunk-O7SK2YUU.js → chunk-SIXIWFC5.js}

@@ -1,6 +1,6 @@
 import {
   getCanonicalUnit
-} from "./chunk-CZLX33DZ.js";
+} from "./chunk-2J3V7DCF.js";
 
 // src/reference-ranges.ts
 var biomarkerRangeDefinitions = {
@@ -247,6 +247,15 @@ var biomarkerRangeDefinitions = {
     kind: "reference-interval",
     source: "tietz-7ed-2015"
   },
+  // BUN (nitrogênio ureico): "The normal range of urea nitrogen in blood or
+  // serum is 5 to 20 mg/dl" (Hosten, Clinical Methods, cap. 193). O capítulo
+  // não publica intervalo ótimo nem partição por sexo ou idade; a queda na
+  // gestação (5 a 7 mg/dL) aparece como contexto, não como intervalo próprio.
+  BUN: {
+    default: { max: 20, min: 5, unit: "mg/dL" },
+    kind: "reference-interval",
+    source: "hosten-clinical-methods-1990"
+  },
   CA125: {
     default: { max: 35, min: 0, optimalMax: 25, optimalMin: 0, unit: "U/mL" },
     kind: "reference-interval",
@@ -2427,4 +2436,4 @@ export {
   getFallbackReferenceRange,
   applyFallbackReferenceRanges
 };
-//# sourceMappingURL=chunk-O7SK2YUU.js.map
+//# sourceMappingURL=chunk-SIXIWFC5.js.map