@precisa-saude/fhir 0.34.0 → 0.35.1

package/dist/{chunk-K3VZ3F5Z.js → chunk-M6AYGD7P.js}

@@ -4,14 +4,15 @@ import {
 } from "./chunk-A6HR4XDK.js";
 import {
   referenceRangeMeaning
-} from "./chunk-P4G534AQ.js";
+} from "./chunk-7TDZX5HO.js";
 import {
   getDefaultUnit,
   resolveUcum
-} from "./chunk-Q3H5C6UR.js";
+} from "./chunk-LWSKO7UV.js";
 import {
-  codeToLoinc
-} from "./chunk-4FKZG5GZ.js";
+  codeToLoinc,
+  methodVariantOf
+} from "./chunk-KTV4H2QQ.js";
 
 // src/bundle-urls.ts
 var BUNDLE_BASE_URL = "https://precisa-saude.com.br/fhir";
@@ -68,7 +69,8 @@ var buildReferenceRanges = (observation, quantity) => {
   );
 };
 function labObservationToFHIR(observation, patientId, laboratoryName) {
-  const loincCode = codeToLoinc(observation.biomarkerCode);
+  const methodLoinc = observation.methodLoinc && methodVariantOf(observation.biomarkerCode, observation.methodLoinc) ? observation.methodLoinc : void 0;
+  const loincCode = methodLoinc ?? codeToLoinc(observation.biomarkerCode);
   const sourceUnit = observation.unit || getDefaultUnit(observation.biomarkerCode) || observation.unit;
   const ucumUnit = resolveUcum(sourceUnit, observation.biomarkerCode);
   const quantity = (value) => ({
@@ -271,4 +273,4 @@ export {
   userProfileToFHIR,
   labResultToFHIRBundle
 };
-//# sourceMappingURL=chunk-K3VZ3F5Z.js.map
+//# sourceMappingURL=chunk-M6AYGD7P.js.map

package/dist/chunk-M6AYGD7P.js.map

@@ -0,0 +1 @@
+{"version":3,"sources":["../src/bundle-urls.ts","../src/converter.ts"],"sourcesContent":["/**\n * Endereço das entradas de um Bundle.\n *\n * O `fullUrl` identifica a entrada, e é contra ele que o validador resolve as\n * referências entre os recursos. Um Bundle com `subject.reference` valendo\n * `Patient/abc` só resolve se alguma entrada tiver `fullUrl` terminando em\n * `/Patient/abc`: a referência relativa é lida contra a base do `fullUrl` da\n * entrada, que é como os exemplos da própria HL7 montam Bundle de coleção.\n *\n * Antes o `fullUrl` era `urn:uuid:observation-<laudo>-<código>`, que erra duas\n * vezes. `urn:uuid:` exige a sintaxe de UUID e aquilo não era um UUID, e num\n * Bundle de entradas `urn:uuid:` a referência precisa repetir a URN inteira,\n * então nenhuma das relativas resolvia. Um laudo de 22 marcadores saía com 24\n * erros de URN e 22 referências perdidas.\n */\n/**\n * Recurso que já tem id, e por isso pode ser endereçado numa entrada.\n *\n * No FHIR o `id` é opcional, porque um recurso pode viajar sem identidade\n * própria. Numa entrada de Bundle ele não pode: sem id não há `fullUrl`, e sem\n * `fullUrl` nenhuma referência chega ao recurso. Os conversores daqui sempre\n * atribuem um, e o tipo passa a dizer isso em vez de deixar `undefined` chegar\n * até a montagem da URL.\n */\nexport type Addressable<T> = T & { id: string };\n\n/**\n * Base dos `fullUrl`.\n *\n * Não precisa responder a uma requisição: no FHIR o `fullUrl` é identidade, não\n * endereço de download. Fica sob um domínio nosso para não colidir com a\n * identidade de recurso de outra instituição, que é o risco real de usar\n * `example.org` em dado que sai da máquina.\n */\nexport const BUNDLE_BASE_URL = 'https://precisa-saude.com.br/fhir';\n\n/**\n * Monta o `fullUrl` a partir do próprio recurso.\n *\n * Recebe o recurso em vez do tipo e do id soltos de propósito. O defeito que\n * isto substitui nasceu de montar os dois lados em separado: o `fullUrl` dizia\n * `observation-demo-Hgb` enquanto o recurso tinha id `demo-Hgb`, e ninguém\n * percebeu porque nada obrigava os dois a concordarem.\n *\n * O parâmetro pede o mínimo que a URL consome, e não a união de recursos que\n * este pacote converte. Um Bundle pode carregar qualquer recurso do R4, e quem\n * acrescenta uma entrada de um tipo que não está nessa união (um `Specimen`,\n * por exemplo) precisa do mesmo endereço, senão monta o dele e as duas formas\n * divergem outra vez.\n */\nexport const entryFullUrl = (resource: Addressable<{ resourceType: string }>): string =>\n  `${BUNDLE_BASE_URL}/${resource.resourceType}/${resource.id}`;\n","/**\n * FHIR Converter\n *\n * Converts lab results to FHIR R4 DiagnosticReport and Observation resources.\n * See: https://hl7.org/fhir/diagnosticreport.html\n */\n\nimport { codeToLoinc, methodVariantOf } from './biomarkers';\nimport { type Addressable, entryFullUrl } from './bundle-urls';\nimport { BIOMARKER_CODE_SYSTEM, LOINC_SYSTEM } from './code-systems';\nimport type {\n  FHIRBundle,\n  FHIRDiagnosticReport,\n  FHIRObservation,\n  FHIRPatient,\n  FHIRQuantity,\n  FHIRReferenceRange,\n} from './fhir-types';\nimport { referenceRangeMeaning } from './reference-ranges';\nimport type { Flag, LabObservationData, LabReportData, UserProfileData } from './types';\nimport { getDefaultUnit, resolveUcum } from './units';\n\n// Re-export all types and functions\nexport * from './fhir-types';\n\n/**\n * Convert Flag to FHIR interpretation code\n */\nfunction interpretationCode(flag: Flag): string {\n  switch (flag) {\n    case 'H':\n      return 'H'; // High\n    case 'L':\n      return 'L'; // Low\n    default:\n      return 'N'; // Normal\n  }\n}\n\n/**\n * Convert Flag to FHIR interpretation display\n */\nfunction interpretationDisplay(flag: Flag): string {\n  switch (flag) {\n    case 'H':\n      return 'High';\n    case 'L':\n      return 'Low';\n    default:\n      return 'Normal';\n  }\n}\n\n/**\n * O `coding` do sexo, que vai **dentro** do CodeableConcept do `appliesTo`.\n *\n * O nome diz `CODING` e não `APPLIES_TO` de propósito: isto não é o valor do\n * campo, é uma entrada da lista de codificações dele. O embrulho acontece no\n * uso, em `{ coding: [SEX_CODING[sex]] }`.\n *\n * É o `AdministrativeGender`, e não o v3-ObservationInterpretation nem um\n * sistema nosso: um consumidor que já lê `Patient.gender` compara os dois sem\n * tabela de tradução no meio.\n */\nconst SEX_CODING = {\n  female: {\n    code: 'female',\n    display: 'Female',\n    system: 'http://hl7.org/fhir/administrative-gender',\n  },\n  male: { code: 'male', display: 'Male', system: 'http://hl7.org/fhir/administrative-gender' },\n} as const;\n\n/**\n * Monta as faixas de referência do `Observation`.\n *\n * Duas mudanças em relação ao que existia, e as duas são sobre não perder o que\n * o laudo imprimiu.\n *\n * **Um limite só já basta.** Antes a faixa só saía com os dois, e um laudo que\n * publica \"inferior a 190 mg/dL\" ou \"superior a 60 mL/min/1,73m²\" perdia o\n * campo inteiro. O R4 trata `low` e `high` como opcionais independentes e\n * documenta o caso de um lado só, e o importador deste mesmo pacote já lia\n * `low?.value` e `high?.value` com acesso opcional: a assimetria era só do\n * escritor. Ver PRE-430.\n *\n * **Mais de uma faixa, anotada.** Laudo com uma coluna de referência por sexo\n * passa a sair com as duas, cada uma com o seu `appliesTo`, em vez de o\n * pipeline escolher uma sem saber de quem é o exame. Ver PRE-424 e PRE-425.\n */\nconst buildReferenceRanges = (\n  observation: LabObservationData,\n  quantity: (value: number) => FHIRQuantity,\n): FHIRReferenceRange[] => {\n  // Devolve lista, e não uma faixa: o caso sem limite nenhum vira lista vazia\n  // em vez de `undefined`, e aí os dois caminhos abaixo se compõem com\n  // `flatMap` sem ninguém precisar filtrar nada depois.\n  const toRanges = (low?: number, high?: number, sex?: 'female' | 'male'): FHIRReferenceRange[] => {\n    if (low === undefined && high === undefined) return [];\n\n    return [\n      {\n        ...(sex === undefined ? {} : { appliesTo: [{ coding: [SEX_CODING[sex]] }] }),\n        ...(high === undefined ? {} : { high: quantity(high) }),\n        ...(low === undefined ? {} : { low: quantity(low) }),\n      },\n    ];\n  };\n\n  // A lista anotada tem precedência: quando ela existe, o par simples é o\n  // resumo de uma das colunas e repeti-lo publicaria a mesma faixa duas vezes,\n  // uma delas sem dizer a quem se aplica.\n  //\n  // Lista vazia cai no par simples, igual a ausente, e isso é escolha: as duas\n  // dizem \"não tenho faixa anotada\", e tratá-las diferente faria um `[]` vindo\n  // de um `.filter()` apagar em silêncio a faixa que o chamador também mandou\n  // em `referenceMin` e `referenceMax`.\n  if (observation.referenceRanges && observation.referenceRanges.length > 0) {\n    return observation.referenceRanges.flatMap((r) => toRanges(r.low, r.high, r.appliesTo));\n  }\n\n  const meaning = observation.referenceKind && referenceRangeMeaning(observation.referenceKind);\n  return toRanges(observation.referenceMin, observation.referenceMax).map((range) =>\n    meaning ? { ...range, type: { coding: [meaning] } } : range,\n  );\n};\n\n/**\n * Convert generic lab observation to FHIR Observation\n */\nexport function labObservationToFHIR(\n  observation: LabObservationData,\n  patientId: string,\n  laboratoryName?: string,\n): Addressable<FHIRObservation> {\n  // O código por método só sai quando é variante declarada do biomarcador. Um\n  // `methodLoinc` qualquer viraria afirmação sob `http://loinc.org` que o\n  // catálogo não conferiu.\n  const methodLoinc =\n    observation.methodLoinc && methodVariantOf(observation.biomarkerCode, observation.methodLoinc)\n      ? observation.methodLoinc\n      : undefined;\n  const loincCode = methodLoinc ?? codeToLoinc(observation.biomarkerCode);\n  // Use default unit if source unit is empty\n  const sourceUnit =\n    observation.unit || getDefaultUnit(observation.biomarkerCode) || observation.unit;\n  // `system` + `code` só saem quando a unidade resolve em UCUM. Unidade que o\n  // pacote não sabe traduzir fica só em `unit`, como texto: afirmar\n  // `http://unitsofmeasure.org` sobre `x10^3/mm3` era publicar um código\n  // falso, e quem consome o Bundle confiando no system trataria aquilo como\n  // UCUM de verdade.\n  const ucumUnit = resolveUcum(sourceUnit, observation.biomarkerCode);\n  const quantity = (value: number): FHIRQuantity => ({\n    ...(ucumUnit ? { code: ucumUnit, system: 'http://unitsofmeasure.org' } : {}),\n    ...(sourceUnit ? { unit: sourceUnit } : {}),\n    value,\n  });\n  const isQualitative = observation.isQualitative || typeof observation.value === 'string';\n\n  // Base observation structure\n  const fhirObs: Addressable<FHIRObservation> = {\n    category: [\n      {\n        coding: [\n          {\n            code: 'laboratory',\n            display: 'Laboratory',\n            system: 'http://terminology.hl7.org/CodeSystem/observation-category',\n          },\n        ],\n      },\n    ],\n    code: {\n      // Sem LOINC, o coding LOINC simplesmente não sai. Antes ia `99999-9`,\n      // que não é código LOINC nenhum: publicava sob `http://loinc.org` uma\n      // afirmação falsa, e quem consumisse o bundle confiando no system\n      // trataria aquilo como código de verdade. Composição corporal, densidade\n      // óssea e escore de cálcio não têm LOINC, e o certo é a lacuna explícita.\n      coding: [\n        ...(loincCode\n          ? [\n              {\n                code: loincCode,\n                display: observation.biomarkerName,\n                system: LOINC_SYSTEM,\n              },\n            ]\n          : []),\n        {\n          code: observation.biomarkerCode,\n          display: observation.biomarkerName,\n          system: BIOMARKER_CODE_SYSTEM,\n        },\n      ],\n      text: observation.biomarkerName,\n    },\n    effectiveDateTime: observation.collectionDate,\n    id: `${observation.reportId}-${observation.biomarkerCode}`,\n    interpretation: [\n      {\n        coding: [\n          {\n            code: interpretationCode(observation.flag),\n            display: interpretationDisplay(observation.flag),\n            system: 'http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation',\n          },\n        ],\n      },\n    ],\n    performer: laboratoryName ? [{ display: laboratoryName }] : undefined,\n    resourceType: 'Observation',\n    status: 'final',\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n  };\n\n  // Add value based on type (qualitative = string, quantitative = number)\n  if (isQualitative) {\n    fhirObs.valueString = String(observation.value);\n  } else {\n    fhirObs.valueQuantity = quantity(observation.value as number);\n\n    // Reference range only applies to quantitative values\n    const referenceRange = buildReferenceRanges(observation, quantity);\n    if (referenceRange.length > 0) fhirObs.referenceRange = referenceRange;\n  }\n\n  return fhirObs;\n}\n\n/**\n * Convert generic lab report to FHIR DiagnosticReport\n */\nexport function labReportToFHIR(\n  report: LabReportData,\n  patientId: string,\n  observationIds: string[],\n): Addressable<FHIRDiagnosticReport> {\n  // Map processing status to FHIR status\n  let status: FHIRDiagnosticReport['status'];\n  switch (report.processingStatus) {\n    case 'complete':\n      status = 'final';\n      break;\n    case 'partial':\n      status = 'partial';\n      break;\n    case 'pending_review':\n      status = 'preliminary';\n      break;\n    default:\n      status = 'final';\n  }\n\n  return {\n    category: [\n      {\n        coding: [\n          {\n            code: 'LAB',\n            display: 'Laboratory',\n            system: 'http://terminology.hl7.org/CodeSystem/v2-0074',\n          },\n        ],\n      },\n    ],\n    code: {\n      coding: [\n        {\n          code: '11502-2', // Laboratory report\n          display: 'Laboratory report',\n          system: 'http://loinc.org',\n        },\n      ],\n      text: 'Laboratory Results',\n    },\n    conclusion:\n      report.overallStatus === 'NORMAL'\n        ? 'All results within normal limits'\n        : 'One or more abnormal results detected',\n    conclusionCode:\n      report.overallStatus === 'ANORMAL'\n        ? [\n            {\n              coding: [\n                {\n                  code: 'A',\n                  display: 'Abnormal',\n                  system: 'http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation',\n                },\n              ],\n            },\n          ]\n        : undefined,\n    effectiveDateTime: report.collectionDate,\n    id: report.reportId,\n    issued: report.createdAt,\n    performer: report.laboratoryName ? [{ display: report.laboratoryName }] : undefined,\n    resourceType: 'DiagnosticReport',\n    result: observationIds.map((id) => ({ reference: `Observation/${id}` })),\n    status,\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n  };\n}\n\n/**\n * Convert user profile to FHIR Patient\n * NOTE: CPF is intentionally excluded for privacy (LGPD compliance)\n */\nexport function userProfileToFHIR(profile: UserProfileData): Addressable<FHIRPatient> {\n  const nameParts = profile.name.split(' ');\n  const given = nameParts.slice(0, -1);\n  const family = nameParts[nameParts.length - 1] || '';\n\n  return {\n    address: profile.address\n      ? [\n          {\n            city: profile.address.city,\n            country: profile.address.country || 'BR',\n            line: [\n              profile.address.street && profile.address.number\n                ? `${profile.address.street}, ${profile.address.number}`\n                : profile.address.street,\n              profile.address.complement,\n            ].filter(Boolean) as string[],\n            postalCode: profile.address.postalCode,\n            state: profile.address.state,\n          },\n        ]\n      : undefined,\n    birthDate: profile.birthDate,\n    gender: profile.gender,\n    id: profile.userId,\n    name: [\n      {\n        family,\n        given: given.length > 0 ? given : undefined,\n        text: profile.name,\n      },\n    ],\n    resourceType: 'Patient',\n    telecom:\n      [\n        ...(profile.email ? [{ system: 'email' as const, value: profile.email }] : []),\n        ...(profile.phone ? [{ system: 'phone' as const, value: profile.phone }] : []),\n      ].length > 0\n        ? [\n            ...(profile.email ? [{ system: 'email' as const, value: profile.email }] : []),\n            ...(profile.phone ? [{ system: 'phone' as const, value: profile.phone }] : []),\n          ]\n        : undefined,\n  };\n}\n\n/**\n * Convert complete lab result to FHIR Bundle\n * This is the main function for exporting lab results to FHIR R4 format\n */\nexport function labResultToFHIRBundle(\n  report: LabReportData,\n  observations: LabObservationData[],\n  userProfile: UserProfileData,\n): FHIRBundle {\n  const patientId = userProfile.userId;\n\n  // Convert observations\n  const fhirObservations = observations.map((obs) => {\n    const resource = labObservationToFHIR(\n      { ...obs, collectionDate: report.collectionDate },\n      patientId,\n      report.laboratoryName,\n    );\n\n    return { fullUrl: entryFullUrl(resource), resource };\n  });\n\n  // Os ids vêm dos recursos já montados, e não de uma segunda montagem da mesma\n  // regra. O `DiagnosticReport.result` aponta para eles, e era aqui que a\n  // referência se separava do recurso.\n  const observationIds = fhirObservations.map((entry) => entry.resource.id);\n\n  // Convert report\n  const diagnosticReport = labReportToFHIR(report, patientId, observationIds);\n\n  // Convert patient\n  const fhirPatient = userProfileToFHIR(userProfile);\n\n  return {\n    entry: [\n      { fullUrl: entryFullUrl(fhirPatient), resource: fhirPatient },\n      { fullUrl: entryFullUrl(diagnosticReport), resource: diagnosticReport },\n      ...fhirObservations,\n    ],\n    resourceType: 'Bundle',\n    type: 'collection',\n  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package/dist/{chunk-OAFAERDY.cjs → chunk-RPGJK7ZM.cjs}

@@ -1,13 +1,13 @@
 "use strict";Object.defineProperty(exports, "__esModule", {value: true}); function _nullishCoalesce(lhs, rhsFn) { if (lhs != null) { return lhs; } else { return rhsFn(); } }
 
-var _chunk5RC7C7HJcjs = require('./chunk-5RC7C7HJ.cjs');
+var _chunkAQTHAZLKcjs = require('./chunk-AQTHAZLK.cjs');
 
 // src/validators.ts
 var UCUM_SYSTEM = "http://unitsofmeasure.org";
 function ucumErrors(quantity, where) {
   if (!quantity || quantity.system !== UCUM_SYSTEM) return [];
   if (!quantity.code) return [`${where}: UCUM system declared without a code`];
-  if (!_chunk5RC7C7HJcjs.isUcumCode.call(void 0, quantity.code)) {
+  if (!_chunkAQTHAZLKcjs.isUcumCode.call(void 0, quantity.code)) {
     return [`${where}: "${quantity.code}" is not a UCUM code`];
   }
   return [];
@@ -78,4 +78,4 @@ function validateFHIRImportBundle(data) {
 
 
 exports.validateFHIRDiagnosticReport = validateFHIRDiagnosticReport; exports.validateFHIRObservation = validateFHIRObservation; exports.validateFHIRImportBundle = validateFHIRImportBundle;
-//# sourceMappingURL=chunk-OAFAERDY.cjs.map
+//# sourceMappingURL=chunk-RPGJK7ZM.cjs.map

package/dist/{chunk-OAFAERDY.cjs.map → chunk-RPGJK7ZM.cjs.map}

@@ -1 +1 @@
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+{"version":3,"sources":["/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/chunk-RPGJK7ZM.cjs","../src/validators.ts"],"names":[],"mappings":"AAAA;AACE;AACF,wDAA6B;AAC7B;AACA;ACMA,IAAM,YAAA,EAAc,2BAAA;AAYpB,SAAS,UAAA,CAAW,QAAA,EAAoC,KAAA,EAAyB;AAC/E,EAAA,GAAA,CAAI,CAAC,SAAA,GAAY,QAAA,CAAS,OAAA,IAAW,WAAA,EAAa,OAAO,CAAC,CAAA;AAC1D,EAAA,GAAA,CAAI,CAAC,QAAA,CAAS,IAAA,EAAM,OAAO,CAAC,CAAA,EAAA;AACC,EAAA;AACL,IAAA;AACxB,EAAA;AACQ,EAAA;AACV;AAKgB;AACY,EAAA;AAEE,EAAA;AACd,IAAA;AACd,EAAA;AAEoB,EAAA;AACN,IAAA;AACd,EAAA;AAE4B,EAAA;AACd,IAAA;AACd,EAAA;AAEwB,EAAA;AACV,IAAA;AACd,EAAA;AAEO,EAAA;AACT;AAKgB;AACY,EAAA;AAET,EAAA;AACH,IAAA;AACd,EAAA;AAEyB,EAAA;AACX,IAAA;AACd,EAAA;AAE0B,EAAA;AACZ,IAAA;AACd,EAAA;AAE6B,EAAA;AACf,IAAA;AACd,EAAA;AAEiB,EAAA;AACH,IAAA;AACd,EAAA;AAE0B,EAAA;AACA,EAAA;AACE,IAAA;AACA,IAAA;AAC5B,EAAA;AAEO,EAAA;AACT;AAKgB;AACiB,EAAA;AAEF,EAAA;AACJ,IAAA;AAChB,IAAA;AACT,EAAA;AAEe,EAAA;AAEa,EAAA;AACd,IAAA;AACD,MAAA;AACF,MAAA;AACR,IAAA;AACH,EAAA;AAE0B,EAAA;AACD,IAAA;AACD,EAAA;AACC,IAAA;AACzB,EAAA;AAEO,EAAA;AACT;AD5C+B;AACA;AACA;AACA;AACA;AACA","file":"/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/chunk-RPGJK7ZM.cjs","sourcesContent":[null,"/**\n * FHIR Validators\n *\n * Validation functions for FHIR R4 resources.\n */\n\nimport type { FHIRDiagnosticReport, FHIRObservation, FHIRQuantity } from './fhir-types';\nimport type { ImportError } from './importer';\nimport { isUcumCode } from './units';\n\nconst UCUM_SYSTEM = 'http://unitsofmeasure.org';\n\n/**\n * Um `Quantity` que afirma o system do UCUM precisa de um `code` que seja\n * UCUM. Sem `code` a afirmação está vazia; com `code` que não é UCUM ela está\n * errada, e foi o caso durante meses: `uIU/mL`, `K/uL` e `razão` saíam sob\n * `http://unitsofmeasure.org` porque o conversor devolvia a grafia do laudo\n * intacta quando não a conhecia.\n *\n * `Quantity` sem `system` passa: unidade só em texto é legítima, e é o que o\n * conversor emite quando não sabe traduzir.\n */\nfunction ucumErrors(quantity: FHIRQuantity | undefined, where: string): string[] {\n  if (!quantity || quantity.system !== UCUM_SYSTEM) return [];\n  if (!quantity.code) return [`${where}: UCUM system declared without a code`];\n  if (!isUcumCode(quantity.code)) {\n    return [`${where}: \"${quantity.code}\" is not a UCUM code`];\n  }\n  return [];\n}\n\n/**\n * Validate FHIR DiagnosticReport\n */\nexport function validateFHIRDiagnosticReport(report: FHIRDiagnosticReport): string[] {\n  const errors: string[] = [];\n\n  if (!report.resourceType || report.resourceType !== 'DiagnosticReport') {\n    errors.push('Invalid resourceType');\n  }\n\n  if (!report.status) {\n    errors.push('Missing status');\n  }\n\n  if (!report.code || !report.code.coding || report.code.coding.length === 0) {\n    errors.push('Missing or invalid code');\n  }\n\n  if (!report.subject || !report.subject.reference) {\n    errors.push('Missing subject reference');\n  }\n\n  return errors;\n}\n\n/**\n * Validate FHIR Observation\n */\nexport function validateFHIRObservation(observation: FHIRObservation): string[] {\n  const errors: string[] = [];\n\n  if (!observation.resourceType || observation.resourceType !== 'Observation') {\n    errors.push('Invalid resourceType');\n  }\n\n  if (!observation.status) {\n    errors.push('Missing status');\n  }\n\n  if (!observation.code || !observation.code.coding || observation.code.coding.length === 0) {\n    errors.push('Missing or invalid code');\n  }\n\n  if (!observation.subject || !observation.subject.reference) {\n    errors.push('Missing subject reference');\n  }\n\n  if (!observation.valueQuantity && !observation.valueString) {\n    errors.push('Missing value (valueQuantity or valueString)');\n  }\n\n  errors.push(...ucumErrors(observation.valueQuantity, 'valueQuantity'));\n  for (const [i, range] of (observation.referenceRange ?? []).entries()) {\n    errors.push(...ucumErrors(range.low, `referenceRange[${i}].low`));\n    errors.push(...ucumErrors(range.high, `referenceRange[${i}].high`));\n  }\n\n  return errors;\n}\n\n/**\n * Validate that the input is a structurally valid FHIR Bundle\n */\nexport function validateFHIRImportBundle(data: unknown): ImportError[] {\n  const errors: ImportError[] = [];\n\n  if (!data || typeof data !== 'object') {\n    errors.push({ details: 'Input must be a JSON object', field: 'root' });\n    return errors;\n  }\n\n  const bundle = data as Record<string, unknown>;\n\n  if (bundle.resourceType !== 'Bundle') {\n    errors.push({\n      details: `Expected resourceType \"Bundle\", got \"${String(bundle.resourceType)}\"`,\n      field: 'resourceType',\n    });\n  }\n\n  if (!Array.isArray(bundle.entry)) {\n    errors.push({ details: 'Bundle must contain an \"entry\" array', field: 'entry' });\n  } else if (bundle.entry.length === 0) {\n    errors.push({ details: 'Bundle entry array is empty', field: 'entry' });\n  }\n\n  return errors;\n}\n"]}

package/dist/{chunk-NKDUVSDK.cjs → chunk-WKTDMR5P.cjs}

@@ -1,17 +1,18 @@
-"use strict";Object.defineProperty(exports, "__esModule", {value: true});
+"use strict";Object.defineProperty(exports, "__esModule", {value: true}); function _nullishCoalesce(lhs, rhsFn) { if (lhs != null) { return lhs; } else { return rhsFn(); } }
 
 
 var _chunkOR67NJDZcjs = require('./chunk-OR67NJDZ.cjs');
 
 
-var _chunkVKLWTTUOcjs = require('./chunk-VKLWTTUO.cjs');
+var _chunkH64L6SOVcjs = require('./chunk-H64L6SOV.cjs');
 
 
 
-var _chunk5RC7C7HJcjs = require('./chunk-5RC7C7HJ.cjs');
+var _chunkAQTHAZLKcjs = require('./chunk-AQTHAZLK.cjs');
 
 
-var _chunkT75NZM56cjs = require('./chunk-T75NZM56.cjs');
+
+var _chunkJES2ZLH5cjs = require('./chunk-JES2ZLH5.cjs');
 
 // src/bundle-urls.ts
 var BUNDLE_BASE_URL = "https://precisa-saude.com.br/fhir";
@@ -62,15 +63,16 @@ var buildReferenceRanges = (observation, quantity) => {
   if (observation.referenceRanges && observation.referenceRanges.length > 0) {
     return observation.referenceRanges.flatMap((r) => toRanges(r.low, r.high, r.appliesTo));
   }
-  const meaning = observation.referenceKind && _chunkVKLWTTUOcjs.referenceRangeMeaning.call(void 0, observation.referenceKind);
+  const meaning = observation.referenceKind && _chunkH64L6SOVcjs.referenceRangeMeaning.call(void 0, observation.referenceKind);
   return toRanges(observation.referenceMin, observation.referenceMax).map(
     (range) => meaning ? { ...range, type: { coding: [meaning] } } : range
   );
 };
 function labObservationToFHIR(observation, patientId, laboratoryName) {
-  const loincCode = _chunkT75NZM56cjs.codeToLoinc.call(void 0, observation.biomarkerCode);
-  const sourceUnit = observation.unit || _chunk5RC7C7HJcjs.getDefaultUnit.call(void 0, observation.biomarkerCode) || observation.unit;
-  const ucumUnit = _chunk5RC7C7HJcjs.resolveUcum.call(void 0, sourceUnit, observation.biomarkerCode);
+  const methodLoinc = observation.methodLoinc && _chunkJES2ZLH5cjs.methodVariantOf.call(void 0, observation.biomarkerCode, observation.methodLoinc) ? observation.methodLoinc : void 0;
+  const loincCode = _nullishCoalesce(methodLoinc, () => ( _chunkJES2ZLH5cjs.codeToLoinc.call(void 0, observation.biomarkerCode)));
+  const sourceUnit = observation.unit || _chunkAQTHAZLKcjs.getDefaultUnit.call(void 0, observation.biomarkerCode) || observation.unit;
+  const ucumUnit = _chunkAQTHAZLKcjs.resolveUcum.call(void 0, sourceUnit, observation.biomarkerCode);
   const quantity = (value) => ({
     ...ucumUnit ? { code: ucumUnit, system: "http://unitsofmeasure.org" } : {},
     ...sourceUnit ? { unit: sourceUnit } : {},
@@ -271,4 +273,4 @@ function labResultToFHIRBundle(report, observations, userProfile) {
 
 
 exports.BUNDLE_BASE_URL = BUNDLE_BASE_URL; exports.entryFullUrl = entryFullUrl; exports.labObservationToFHIR = labObservationToFHIR; exports.labReportToFHIR = labReportToFHIR; exports.userProfileToFHIR = userProfileToFHIR; exports.labResultToFHIRBundle = labResultToFHIRBundle;
-//# sourceMappingURL=chunk-NKDUVSDK.cjs.map
+//# sourceMappingURL=chunk-WKTDMR5P.cjs.map

package/dist/chunk-WKTDMR5P.cjs.map

@@ -0,0 +1 @@
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Um Bundle com `subject.reference` valendo\n * `Patient/abc` só resolve se alguma entrada tiver `fullUrl` terminando em\n * `/Patient/abc`: a referência relativa é lida contra a base do `fullUrl` da\n * entrada, que é como os exemplos da própria HL7 montam Bundle de coleção.\n *\n * Antes o `fullUrl` era `urn:uuid:observation-<laudo>-<código>`, que erra duas\n * vezes. `urn:uuid:` exige a sintaxe de UUID e aquilo não era um UUID, e num\n * Bundle de entradas `urn:uuid:` a referência precisa repetir a URN inteira,\n * então nenhuma das relativas resolvia. Um laudo de 22 marcadores saía com 24\n * erros de URN e 22 referências perdidas.\n */\n/**\n * Recurso que já tem id, e por isso pode ser endereçado numa entrada.\n *\n * No FHIR o `id` é opcional, porque um recurso pode viajar sem identidade\n * própria. Numa entrada de Bundle ele não pode: sem id não há `fullUrl`, e sem\n * `fullUrl` nenhuma referência chega ao recurso. Os conversores daqui sempre\n * atribuem um, e o tipo passa a dizer isso em vez de deixar `undefined` chegar\n * até a montagem da URL.\n */\nexport type Addressable<T> = T & { id: string };\n\n/**\n * Base dos `fullUrl`.\n *\n * Não precisa responder a uma requisição: no FHIR o `fullUrl` é identidade, não\n * endereço de download. Fica sob um domínio nosso para não colidir com a\n * identidade de recurso de outra instituição, que é o risco real de usar\n * `example.org` em dado que sai da máquina.\n */\nexport const BUNDLE_BASE_URL = 'https://precisa-saude.com.br/fhir';\n\n/**\n * Monta o `fullUrl` a partir do próprio recurso.\n *\n * Recebe o recurso em vez do tipo e do id soltos de propósito. O defeito que\n * isto substitui nasceu de montar os dois lados em separado: o `fullUrl` dizia\n * `observation-demo-Hgb` enquanto o recurso tinha id `demo-Hgb`, e ninguém\n * percebeu porque nada obrigava os dois a concordarem.\n *\n * O parâmetro pede o mínimo que a URL consome, e não a união de recursos que\n * este pacote converte. Um Bundle pode carregar qualquer recurso do R4, e quem\n * acrescenta uma entrada de um tipo que não está nessa união (um `Specimen`,\n * por exemplo) precisa do mesmo endereço, senão monta o dele e as duas formas\n * divergem outra vez.\n */\nexport const entryFullUrl = (resource: Addressable<{ resourceType: string }>): string =>\n  `${BUNDLE_BASE_URL}/${resource.resourceType}/${resource.id}`;\n","/**\n * FHIR Converter\n *\n * Converts lab results to FHIR R4 DiagnosticReport and Observation resources.\n * See: https://hl7.org/fhir/diagnosticreport.html\n */\n\nimport { codeToLoinc, methodVariantOf } from './biomarkers';\nimport { type Addressable, entryFullUrl } from './bundle-urls';\nimport { BIOMARKER_CODE_SYSTEM, LOINC_SYSTEM } from './code-systems';\nimport type {\n  FHIRBundle,\n  FHIRDiagnosticReport,\n  FHIRObservation,\n  FHIRPatient,\n  FHIRQuantity,\n  FHIRReferenceRange,\n} from './fhir-types';\nimport { referenceRangeMeaning } from './reference-ranges';\nimport type { Flag, LabObservationData, LabReportData, UserProfileData } from './types';\nimport { getDefaultUnit, resolveUcum } from './units';\n\n// Re-export all types and functions\nexport * from './fhir-types';\n\n/**\n * Convert Flag to FHIR interpretation code\n */\nfunction interpretationCode(flag: Flag): string {\n  switch (flag) {\n    case 'H':\n      return 'H'; // High\n    case 'L':\n      return 'L'; // Low\n    default:\n      return 'N'; // Normal\n  }\n}\n\n/**\n * Convert Flag to FHIR interpretation display\n */\nfunction interpretationDisplay(flag: Flag): string {\n  switch (flag) {\n    case 'H':\n      return 'High';\n    case 'L':\n      return 'Low';\n    default:\n      return 'Normal';\n  }\n}\n\n/**\n * O `coding` do sexo, que vai **dentro** do CodeableConcept do `appliesTo`.\n *\n * O nome diz `CODING` e não `APPLIES_TO` de propósito: isto não é o valor do\n * campo, é uma entrada da lista de codificações dele. O embrulho acontece no\n * uso, em `{ coding: [SEX_CODING[sex]] }`.\n *\n * É o `AdministrativeGender`, e não o v3-ObservationInterpretation nem um\n * sistema nosso: um consumidor que já lê `Patient.gender` compara os dois sem\n * tabela de tradução no meio.\n */\nconst SEX_CODING = {\n  female: {\n    code: 'female',\n    display: 'Female',\n    system: 'http://hl7.org/fhir/administrative-gender',\n  },\n  male: { code: 'male', display: 'Male', system: 'http://hl7.org/fhir/administrative-gender' },\n} as const;\n\n/**\n * Monta as faixas de referência do `Observation`.\n *\n * Duas mudanças em relação ao que existia, e as duas são sobre não perder o que\n * o laudo imprimiu.\n *\n * **Um limite só já basta.** Antes a faixa só saía com os dois, e um laudo que\n * publica \"inferior a 190 mg/dL\" ou \"superior a 60 mL/min/1,73m²\" perdia o\n * campo inteiro. O R4 trata `low` e `high` como opcionais independentes e\n * documenta o caso de um lado só, e o importador deste mesmo pacote já lia\n * `low?.value` e `high?.value` com acesso opcional: a assimetria era só do\n * escritor. Ver PRE-430.\n *\n * **Mais de uma faixa, anotada.** Laudo com uma coluna de referência por sexo\n * passa a sair com as duas, cada uma com o seu `appliesTo`, em vez de o\n * pipeline escolher uma sem saber de quem é o exame. Ver PRE-424 e PRE-425.\n */\nconst buildReferenceRanges = (\n  observation: LabObservationData,\n  quantity: (value: number) => FHIRQuantity,\n): FHIRReferenceRange[] => {\n  // Devolve lista, e não uma faixa: o caso sem limite nenhum vira lista vazia\n  // em vez de `undefined`, e aí os dois caminhos abaixo se compõem com\n  // `flatMap` sem ninguém precisar filtrar nada depois.\n  const toRanges = (low?: number, high?: number, sex?: 'female' | 'male'): FHIRReferenceRange[] => {\n    if (low === undefined && high === undefined) return [];\n\n    return [\n      {\n        ...(sex === undefined ? {} : { appliesTo: [{ coding: [SEX_CODING[sex]] }] }),\n        ...(high === undefined ? {} : { high: quantity(high) }),\n        ...(low === undefined ? {} : { low: quantity(low) }),\n      },\n    ];\n  };\n\n  // A lista anotada tem precedência: quando ela existe, o par simples é o\n  // resumo de uma das colunas e repeti-lo publicaria a mesma faixa duas vezes,\n  // uma delas sem dizer a quem se aplica.\n  //\n  // Lista vazia cai no par simples, igual a ausente, e isso é escolha: as duas\n  // dizem \"não tenho faixa anotada\", e tratá-las diferente faria um `[]` vindo\n  // de um `.filter()` apagar em silêncio a faixa que o chamador também mandou\n  // em `referenceMin` e `referenceMax`.\n  if (observation.referenceRanges && observation.referenceRanges.length > 0) {\n    return observation.referenceRanges.flatMap((r) => toRanges(r.low, r.high, r.appliesTo));\n  }\n\n  const meaning = observation.referenceKind && referenceRangeMeaning(observation.referenceKind);\n  return toRanges(observation.referenceMin, observation.referenceMax).map((range) =>\n    meaning ? { ...range, type: { coding: [meaning] } } : range,\n  );\n};\n\n/**\n * Convert generic lab observation to FHIR Observation\n */\nexport function labObservationToFHIR(\n  observation: LabObservationData,\n  patientId: string,\n  laboratoryName?: string,\n): Addressable<FHIRObservation> {\n  // O código por método só sai quando é variante declarada do biomarcador. Um\n  // `methodLoinc` qualquer viraria afirmação sob `http://loinc.org` que o\n  // catálogo não conferiu.\n  const methodLoinc =\n    observation.methodLoinc && methodVariantOf(observation.biomarkerCode, observation.methodLoinc)\n      ? observation.methodLoinc\n      : undefined;\n  const loincCode = methodLoinc ?? codeToLoinc(observation.biomarkerCode);\n  // Use default unit if source unit is empty\n  const sourceUnit =\n    observation.unit || getDefaultUnit(observation.biomarkerCode) || observation.unit;\n  // `system` + `code` só saem quando a unidade resolve em UCUM. Unidade que o\n  // pacote não sabe traduzir fica só em `unit`, como texto: afirmar\n  // `http://unitsofmeasure.org` sobre `x10^3/mm3` era publicar um código\n  // falso, e quem consome o Bundle confiando no system trataria aquilo como\n  // UCUM de verdade.\n  const ucumUnit = resolveUcum(sourceUnit, observation.biomarkerCode);\n  const quantity = (value: number): FHIRQuantity => ({\n    ...(ucumUnit ? { code: ucumUnit, system: 'http://unitsofmeasure.org' } : {}),\n    ...(sourceUnit ? { unit: sourceUnit } : {}),\n    value,\n  });\n  const isQualitative = observation.isQualitative || typeof observation.value === 'string';\n\n  // Base observation structure\n  const fhirObs: Addressable<FHIRObservation> = {\n    category: [\n      {\n        coding: [\n          {\n            code: 'laboratory',\n            display: 'Laboratory',\n            system: 'http://terminology.hl7.org/CodeSystem/observation-category',\n          },\n        ],\n      },\n    ],\n    code: {\n      // Sem LOINC, o coding LOINC simplesmente não sai. Antes ia `99999-9`,\n      // que não é código LOINC nenhum: publicava sob `http://loinc.org` uma\n      // afirmação falsa, e quem consumisse o bundle confiando no system\n      // trataria aquilo como código de verdade. Composição corporal, densidade\n      // óssea e escore de cálcio não têm LOINC, e o certo é a lacuna explícita.\n      coding: [\n        ...(loincCode\n          ? [\n              {\n                code: loincCode,\n                display: observation.biomarkerName,\n                system: LOINC_SYSTEM,\n              },\n            ]\n          : []),\n        {\n          code: observation.biomarkerCode,\n          display: observation.biomarkerName,\n          system: BIOMARKER_CODE_SYSTEM,\n        },\n      ],\n      text: observation.biomarkerName,\n    },\n    effectiveDateTime: observation.collectionDate,\n    id: `${observation.reportId}-${observation.biomarkerCode}`,\n    interpretation: [\n      {\n        coding: [\n          {\n            code: interpretationCode(observation.flag),\n            display: interpretationDisplay(observation.flag),\n            system: 'http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation',\n          },\n        ],\n      },\n    ],\n    performer: laboratoryName ? [{ display: laboratoryName }] : undefined,\n    resourceType: 'Observation',\n    status: 'final',\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n  };\n\n  // Add value based on type (qualitative = string, quantitative = number)\n  if (isQualitative) {\n    fhirObs.valueString = String(observation.value);\n  } else {\n    fhirObs.valueQuantity = quantity(observation.value as number);\n\n    // Reference range only applies to quantitative values\n    const referenceRange = buildReferenceRanges(observation, quantity);\n    if (referenceRange.length > 0) fhirObs.referenceRange = referenceRange;\n  }\n\n  return fhirObs;\n}\n\n/**\n * Convert generic lab report to FHIR DiagnosticReport\n */\nexport function labReportToFHIR(\n  report: LabReportData,\n  patientId: string,\n  observationIds: string[],\n): Addressable<FHIRDiagnosticReport> {\n  // Map processing status to FHIR status\n  let status: FHIRDiagnosticReport['status'];\n  switch (report.processingStatus) {\n    case 'complete':\n      status = 'final';\n      break;\n    case 'partial':\n      status = 'partial';\n      break;\n    case 'pending_review':\n      status = 'preliminary';\n      break;\n    default:\n      status = 'final';\n  }\n\n  return {\n    category: [\n      {\n        coding: [\n          {\n            code: 'LAB',\n            display: 'Laboratory',\n            system: 'http://terminology.hl7.org/CodeSystem/v2-0074',\n          },\n        ],\n      },\n    ],\n    code: {\n      coding: [\n        {\n          code: '11502-2', // Laboratory report\n          display: 'Laboratory report',\n          system: 'http://loinc.org',\n        },\n      ],\n      text: 'Laboratory Results',\n    },\n    conclusion:\n      report.overallStatus === 'NORMAL'\n        ? 'All results within normal limits'\n        : 'One or more abnormal results detected',\n    conclusionCode:\n      report.overallStatus === 'ANORMAL'\n        ? [\n            {\n              coding: [\n                {\n                  code: 'A',\n                  display: 'Abnormal',\n                  system: 'http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation',\n                },\n              ],\n            },\n          ]\n        : undefined,\n    effectiveDateTime: report.collectionDate,\n    id: report.reportId,\n    issued: report.createdAt,\n    performer: report.laboratoryName ? [{ display: report.laboratoryName }] : undefined,\n    resourceType: 'DiagnosticReport',\n    result: observationIds.map((id) => ({ reference: `Observation/${id}` })),\n    status,\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n  };\n}\n\n/**\n * Convert user profile to FHIR Patient\n * NOTE: CPF is intentionally excluded for privacy (LGPD compliance)\n */\nexport function userProfileToFHIR(profile: UserProfileData): Addressable<FHIRPatient> {\n  const nameParts = profile.name.split(' ');\n  const given = nameParts.slice(0, -1);\n  const family = nameParts[nameParts.length - 1] || '';\n\n  return {\n    address: profile.address\n      ? [\n          {\n            city: profile.address.city,\n            country: profile.address.country || 'BR',\n            line: [\n              profile.address.street && profile.address.number\n                ? `${profile.address.street}, ${profile.address.number}`\n                : profile.address.street,\n              profile.address.complement,\n            ].filter(Boolean) as string[],\n            postalCode: profile.address.postalCode,\n            state: profile.address.state,\n          },\n        ]\n      : undefined,\n    birthDate: profile.birthDate,\n    gender: profile.gender,\n    id: profile.userId,\n    name: [\n      {\n        family,\n        given: given.length > 0 ? given : undefined,\n        text: profile.name,\n      },\n    ],\n    resourceType: 'Patient',\n    telecom:\n      [\n        ...(profile.email ? [{ system: 'email' as const, value: profile.email }] : []),\n        ...(profile.phone ? [{ system: 'phone' as const, value: profile.phone }] : []),\n      ].length > 0\n        ? [\n            ...(profile.email ? [{ system: 'email' as const, value: profile.email }] : []),\n            ...(profile.phone ? [{ system: 'phone' as const, value: profile.phone }] : []),\n          ]\n        : undefined,\n  };\n}\n\n/**\n * Convert complete lab result to FHIR Bundle\n * This is the main function for exporting lab results to FHIR R4 format\n */\nexport function labResultToFHIRBundle(\n  report: LabReportData,\n  observations: LabObservationData[],\n  userProfile: UserProfileData,\n): FHIRBundle {\n  const patientId = userProfile.userId;\n\n  // Convert observations\n  const fhirObservations = observations.map((obs) => {\n    const resource = labObservationToFHIR(\n      { ...obs, collectionDate: report.collectionDate },\n      patientId,\n      report.laboratoryName,\n    );\n\n    return { fullUrl: entryFullUrl(resource), resource };\n  });\n\n  // Os ids vêm dos recursos já montados, e não de uma segunda montagem da mesma\n  // regra. O `DiagnosticReport.result` aponta para eles, e era aqui que a\n  // referência se separava do recurso.\n  const observationIds = fhirObservations.map((entry) => entry.resource.id);\n\n  // Convert report\n  const diagnosticReport = labReportToFHIR(report, patientId, observationIds);\n\n  // Convert patient\n  const fhirPatient = userProfileToFHIR(userProfile);\n\n  return {\n    entry: [\n      { fullUrl: entryFullUrl(fhirPatient), resource: fhirPatient },\n      { fullUrl: entryFullUrl(diagnosticReport), resource: diagnosticReport },\n      ...fhirObservations,\n    ],\n    resourceType: 'Bundle',\n    type: 'collection',\n  };\n}\n"]}

package/dist/{chunk-E6MXDQXW.js → chunk-YI5WYZCP.js}

@@ -1,6 +1,6 @@
 import {
   isUcumCode
-} from "./chunk-Q3H5C6UR.js";
+} from "./chunk-LWSKO7UV.js";
 
 // src/validators.ts
 var UCUM_SYSTEM = "http://unitsofmeasure.org";
@@ -78,4 +78,4 @@ export {
   validateFHIRObservation,
   validateFHIRImportBundle
 };
-//# sourceMappingURL=chunk-E6MXDQXW.js.map
+//# sourceMappingURL=chunk-YI5WYZCP.js.map

package/dist/cli.js

@@ -115,6 +115,32 @@ var BIOMARKER_DEFINITIONS = [
     category: "coracao",
     code: "LDL",
     loinc: "2089-1",
+    // Os três irmãos de 2089-1 no eixo Method, conferidos ativos em out/2026.
+    // Medido em três dezenas de laudos reais, a única pista escrita foi a
+    // nota de rodapé de um laboratório norte-americano que declara o cálculo de
+    // Martin-Hopkins. Nenhum laudo brasileiro do corpus imprimiu "calculado",
+    // "direto" ou "Método:" perto do LDL, e por isso as outras duas variantes
+    // ficam sem pista até aparecer laudo que as afirme.
+    methodVariants: [
+      {
+        cues: { en: ["calculated using the Martin-Hopkins"], pt: [] },
+        loinc: "96259-7",
+        method: "Calculated.Martin-Hopkins",
+        note: 'Rodap\xE9 "LDL-C is now calculated using the Martin-Hopkins calculation", que menciona Friedewald s\xF3 para comparar. Por isso a pista \xE9 a frase afirmativa, e n\xE3o o nome do m\xE9todo.'
+      },
+      {
+        cues: { en: [], pt: [] },
+        loinc: "13457-7",
+        method: "Calculated",
+        note: "Friedewald. Sem pista: nenhum laudo do corpus afirmou o c\xE1lculo por escrito."
+      },
+      {
+        cues: { en: [], pt: [] },
+        loinc: "18262-6",
+        method: "Direct assay",
+        note: "Dosagem direta. Sem pista: nenhum laudo do corpus afirmou o m\xE9todo por escrito."
+      }
+    ],
     names: {
       en: ["LDL Cholesterol", "LDL", "Low-Density Lipoprotein"],
       pt: ["Colesterol LDL", "LDL", "LDL-Colesterol"]
@@ -3121,7 +3147,15 @@ var BIOMARKER_DEFINITIONS = [
   {
     category: "sangue",
     code: "DDimer",
-    loinc: "48066-5",
+    // 48065-7 é "Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma".
+    // Até out/2026 apontava para 48066-5, o mesmo analito em DDU (unidades de
+    // D-dímero), que vale cerca de metade do FEU. A faixa do catálogo (500
+    // ng/mL, com o corte por idade de idade × 10) é da convenção FEU, e um
+    // resultado em DDU avaliado contra ela deixaria passar metade dos
+    // anormais. Sem alias: DDU é outra grandeza. Quando o laudo imprime só
+    // "ng/mL", não há como saber a convenção pelo texto; o FEU é o que a
+    // faixa pressupõe.
+    loinc: "48065-7",
     names: {
       en: ["D-Dimer", "D Dimer", "Fibrin D-Dimer"],
       pt: ["D\xEDmero-D", "D\xEDmero D", "D-D\xEDmero"]
@@ -3313,6 +3347,10 @@ for (const def of BIOMARKER_DEFINITIONS) {
       validLoincSet.add(alias);
     }
   }
+  for (const variant of def.methodVariants ?? []) {
+    loincToCodeMap.set(variant.loinc, def.code);
+    validLoincSet.add(variant.loinc);
+  }
   if (def.codeAliases) {
     for (const alias of def.codeAliases) {
       codeAliasToCanonicalMap.set(alias, def.code);
@@ -3324,6 +3362,9 @@ for (const def of BIOMARKER_DEFINITIONS) {
 function loincToCode(loinc) {
   return loincToCodeMap.get(loinc);
 }
+function methodVariantOf(code, loinc) {
+  return codeToDefinitionMap.get(code)?.methodVariants?.find((v) => v.loinc === loinc);
+}
 function codeToLoinc(code) {
   return codeToLoincMap.get(code);
 }
@@ -4865,10 +4906,15 @@ var biomarkerRangeDefinitions = {
   // representada por zonas verde/amarela. Em pacientes > 50 anos,
   // diretrizes (ESC 2019, ACEP) recomendam corte ajustado pela idade:
   // idade × 10 ng/mL (até 750 ng/mL aos 75+).
+  //
+  // Todos os valores são em FEU (unidades equivalentes de fibrinogênio), e o
+  // código do catálogo é o do FEU (48065-7). Em DDU os cortes caem pela
+  // metade; não existe faixa DDU aqui.
   DDimer: {
     default: { max: 500, min: 0, unit: "ng/mL" },
     direction: "lower-better",
     kind: "decision-threshold",
+    loinc: "48065-7",
     source: "wells-ddimer-2003",
     variants: [
       // Corte ajustado por idade — ESC 2019 (Konstantinides et al.) e
@@ -5514,6 +5560,7 @@ var biomarkerRangeDefinitions = {
     default: { max: 125, min: 0, optimalMax: 75, optimalMin: 0, unit: "nmol/L" },
     direction: "lower-better",
     kind: "decision-threshold",
+    loinc: "43583-4",
     source: "sbc-lipids-2025"
   },
   // `Lymphocytes` (%) fica sem faixa de propósito e `Lymphocytes_Abs` usa os limites da
@@ -5980,6 +6027,7 @@ var biomarkerRangeDefinitions = {
   TroponinI: {
     default: { max: 0.04, min: 0, optimalMax: 0.02, optimalMin: 0, unit: "ng/mL" },
     kind: "reference-interval",
+    loinc: "49563-0",
     source: "keller-tni-2013"
   },
   // TroponinT: 14 ng/L = percentil 99 hs-cTnT (ensaio Roche Elecsys 5ª geração)
@@ -6831,7 +6879,8 @@ var buildReferenceRanges = (observation, quantity) => {
   );
 };
 function labObservationToFHIR(observation, patientId, laboratoryName) {
-  const loincCode = codeToLoinc(observation.biomarkerCode);
+  const methodLoinc = observation.methodLoinc && methodVariantOf(observation.biomarkerCode, observation.methodLoinc) ? observation.methodLoinc : void 0;
+  const loincCode = methodLoinc ?? codeToLoinc(observation.biomarkerCode);
   const sourceUnit = observation.unit || getDefaultUnit(observation.biomarkerCode) || observation.unit;
   const ucumUnit = resolveUcum(sourceUnit, observation.biomarkerCode);
   const quantity = (value) => ({
@@ -7179,6 +7228,7 @@ function mapFHIRObservationToInternal(observation, index) {
     flag: extractFlag(observation),
     isQualitative,
     loincCode,
+    ...loincCode && methodVariantOf(internalCode, loincCode) && { methodLoinc: loincCode },
     ...referenceKind && { referenceKind },
     referenceMax,
     referenceMin,
@@ -7877,7 +7927,7 @@ var COMMANDS = {
 async function main() {
   const { command, help, json, resto, version } = dividirArgv(process.argv.slice(2));
   if (version) {
-    process.stdout.write(`${"0.34.0"}
+    process.stdout.write(`${"0.35.1"}
 `);
     return;
   }

package/dist/{converter-UygMzWlL.d.ts → converter-CTj83kPz.d.ts}

@@ -101,6 +101,12 @@ interface LabObservationData {
     collectionDate?: string;
     flag: Flag;
     isQualitative?: boolean;
+    /**
+     * O LOINC por método, quando o laudo afirmou o método por escrito. Só vale
+     * se for uma das `methodVariants` declaradas para o biomarcador; qualquer
+     * outro valor é ignorado e sai o código sem método.
+     */
+    methodLoinc?: string;
     /**
      * Tipo da faixa simples (`referenceMin`/`referenceMax`), quando quem chama
      * sabe. Sai como `referenceRange.type`. Faixa impressa pelo laboratório

package/dist/{converter-DP8VkkO3.d.cts → converter-Dlwb6OfB.d.cts}

@@ -101,6 +101,12 @@ interface LabObservationData {
     collectionDate?: string;
     flag: Flag;
     isQualitative?: boolean;
+    /**
+     * O LOINC por método, quando o laudo afirmou o método por escrito. Só vale
+     * se for uma das `methodVariants` declaradas para o biomarcador; qualquer
+     * outro valor é ignorado e sai o código sem método.
+     */
+    methodLoinc?: string;
     /**
      * Tipo da faixa simples (`referenceMin`/`referenceMax`), quando quem chama
      * sabe. Sai como `referenceRange.type`. Faixa impressa pelo laboratório

package/dist/converter.cjs

@@ -3,15 +3,15 @@
 
 
 
-var _chunkNKDUVSDKcjs = require('./chunk-NKDUVSDK.cjs');
+var _chunkWKTDMR5Pcjs = require('./chunk-WKTDMR5P.cjs');
 require('./chunk-OR67NJDZ.cjs');
-require('./chunk-VKLWTTUO.cjs');
-require('./chunk-5RC7C7HJ.cjs');
-require('./chunk-T75NZM56.cjs');
+require('./chunk-H64L6SOV.cjs');
+require('./chunk-AQTHAZLK.cjs');
+require('./chunk-JES2ZLH5.cjs');
 
 
 
 
 
-exports.labObservationToFHIR = _chunkNKDUVSDKcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkNKDUVSDKcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkNKDUVSDKcjs.labResultToFHIRBundle; exports.userProfileToFHIR = _chunkNKDUVSDKcjs.userProfileToFHIR;
+exports.labObservationToFHIR = _chunkWKTDMR5Pcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkWKTDMR5Pcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkWKTDMR5Pcjs.labResultToFHIRBundle; exports.userProfileToFHIR = _chunkWKTDMR5Pcjs.userProfileToFHIR;
 //# sourceMappingURL=converter.cjs.map

package/dist/converter.d.cts

@@ -1,3 +1,3 @@
-export { l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-DP8VkkO3.cjs';
+export { l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-Dlwb6OfB.cjs';
 export { e as FHIRAddress, f as FHIRAnnotation, g as FHIRAttachment, b as FHIRBundle, h as FHIRBundleEntry, i as FHIRCodeableConcept, d as FHIRCoding, j as FHIRContactPoint, k as FHIRDiagnosticReport, l as FHIRHumanName, c as FHIRIdentifier, F as FHIRMedicationStatement, a as FHIRObservation, m as FHIRPatient, n as FHIRPeriod, o as FHIRQuantity, p as FHIRReference, q as FHIRReferenceRange } from './fhir-types-Cn5WFbOI.cjs';
 import './reference-ranges.cjs';

package/dist/converter.d.ts

@@ -1,3 +1,3 @@
-export { l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-UygMzWlL.js';
+export { l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-CTj83kPz.js';
 export { e as FHIRAddress, f as FHIRAnnotation, g as FHIRAttachment, b as FHIRBundle, h as FHIRBundleEntry, i as FHIRCodeableConcept, d as FHIRCoding, j as FHIRContactPoint, k as FHIRDiagnosticReport, l as FHIRHumanName, c as FHIRIdentifier, F as FHIRMedicationStatement, a as FHIRObservation, m as FHIRPatient, n as FHIRPeriod, o as FHIRQuantity, p as FHIRReference, q as FHIRReferenceRange } from './fhir-types-Cn5WFbOI.js';
 import './reference-ranges.js';

package/dist/converter.js

@@ -3,11 +3,11 @@ import {
   labReportToFHIR,
   labResultToFHIRBundle,
   userProfileToFHIR
-} from "./chunk-K3VZ3F5Z.js";
+} from "./chunk-M6AYGD7P.js";
 import "./chunk-A6HR4XDK.js";
-import "./chunk-P4G534AQ.js";
-import "./chunk-Q3H5C6UR.js";
-import "./chunk-4FKZG5GZ.js";
+import "./chunk-7TDZX5HO.js";
+import "./chunk-LWSKO7UV.js";
+import "./chunk-KTV4H2QQ.js";
 export {
   labObservationToFHIR,
   labReportToFHIR,

package/dist/importer.cjs

@@ -4,16 +4,16 @@
 
 
 
-var _chunk376KM7ILcjs = require('./chunk-376KM7IL.cjs');
-require('./chunk-OAFAERDY.cjs');
+var _chunkF7CC4SV5cjs = require('./chunk-F7CC4SV5.cjs');
+require('./chunk-RPGJK7ZM.cjs');
 require('./chunk-OR67NJDZ.cjs');
-require('./chunk-5RC7C7HJ.cjs');
-require('./chunk-T75NZM56.cjs');
+require('./chunk-AQTHAZLK.cjs');
+require('./chunk-JES2ZLH5.cjs');
 
 
 
 
 
 
-exports.MAX_FILE_SIZE = _chunk376KM7ILcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunk376KM7ILcjs.MAX_OBSERVATIONS; exports.extractObservationsFromBundle = _chunk376KM7ILcjs.extractObservationsFromBundle; exports.mapFHIRObservationToInternal = _chunk376KM7ILcjs.mapFHIRObservationToInternal; exports.processImportBundle = _chunk376KM7ILcjs.processImportBundle;
+exports.MAX_FILE_SIZE = _chunkF7CC4SV5cjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkF7CC4SV5cjs.MAX_OBSERVATIONS; exports.extractObservationsFromBundle = _chunkF7CC4SV5cjs.extractObservationsFromBundle; exports.mapFHIRObservationToInternal = _chunkF7CC4SV5cjs.mapFHIRObservationToInternal; exports.processImportBundle = _chunkF7CC4SV5cjs.processImportBundle;
 //# sourceMappingURL=importer.cjs.map

package/dist/importer.d.cts

@@ -15,6 +15,8 @@ interface ImportedObservation {
     isQualitative: boolean;
     /** Ausente nos biomarcadores sem LOINC publicado, como composição corporal. */
     loincCode?: string;
+    /** O `loincCode` quando ele é uma das variantes por método do biomarcador. */
+    methodLoinc?: string;
     /** Lido do `referenceRange.type`, quando o Bundle o traz. */
     referenceKind?: 'decision-threshold' | 'reference-interval';
     referenceMax?: number;

package/dist/importer.d.ts

@@ -15,6 +15,8 @@ interface ImportedObservation {
     isQualitative: boolean;
     /** Ausente nos biomarcadores sem LOINC publicado, como composição corporal. */
     loincCode?: string;
+    /** O `loincCode` quando ele é uma das variantes por método do biomarcador. */
+    methodLoinc?: string;
     /** Lido do `referenceRange.type`, quando o Bundle o traz. */
     referenceKind?: 'decision-threshold' | 'reference-interval';
     referenceMax?: number;

package/dist/importer.js

@@ -4,11 +4,11 @@ import {
   extractObservationsFromBundle,
   mapFHIRObservationToInternal,
   processImportBundle
-} from "./chunk-NJM45WAH.js";
-import "./chunk-E6MXDQXW.js";
+} from "./chunk-3UCY4HPJ.js";
+import "./chunk-YI5WYZCP.js";
 import "./chunk-A6HR4XDK.js";
-import "./chunk-Q3H5C6UR.js";
-import "./chunk-4FKZG5GZ.js";
+import "./chunk-LWSKO7UV.js";
+import "./chunk-KTV4H2QQ.js";
 export {
   MAX_FILE_SIZE,
   MAX_OBSERVATIONS,

package/dist/index.cjs

@@ -5,19 +5,19 @@
 
 
 
-var _chunkNKDUVSDKcjs = require('./chunk-NKDUVSDK.cjs');
+var _chunkWKTDMR5Pcjs = require('./chunk-WKTDMR5P.cjs');
 
 
 
 
 
 
-var _chunk376KM7ILcjs = require('./chunk-376KM7IL.cjs');
+var _chunkF7CC4SV5cjs = require('./chunk-F7CC4SV5.cjs');
 
 
 
 
-var _chunkOAFAERDYcjs = require('./chunk-OAFAERDY.cjs');
+var _chunkRPGJK7ZMcjs = require('./chunk-RPGJK7ZM.cjs');
 
 
 
@@ -31,7 +31,7 @@ var _chunkOR67NJDZcjs = require('./chunk-OR67NJDZ.cjs');
 
 
 
-var _chunkVKLWTTUOcjs = require('./chunk-VKLWTTUO.cjs');
+var _chunkH64L6SOVcjs = require('./chunk-H64L6SOV.cjs');
 
 
 
@@ -47,7 +47,7 @@ var _chunk5FMR2U7Pcjs = require('./chunk-5FMR2U7P.cjs');
 
 
 
-var _chunk5RC7C7HJcjs = require('./chunk-5RC7C7HJ.cjs');
+var _chunkAQTHAZLKcjs = require('./chunk-AQTHAZLK.cjs');
 
 
 
@@ -80,7 +80,8 @@ var _chunk5RC7C7HJcjs = require('./chunk-5RC7C7HJ.cjs');
 
 
 
-var _chunkT75NZM56cjs = require('./chunk-T75NZM56.cjs');
+
+var _chunkJES2ZLH5cjs = require('./chunk-JES2ZLH5.cjs');
 
 // src/category-groups.ts
 var CATEGORY_GROUPS = {
@@ -242,14 +243,14 @@ function interventionToFHIRObservation(intervention, patientId) {
 }
 function interventionsToFHIRBundle(interventions, userProfile) {
   const patientId = userProfile.userId;
-  const fhirPatient = _chunkNKDUVSDKcjs.userProfileToFHIR.call(void 0, userProfile);
+  const fhirPatient = _chunkWKTDMR5Pcjs.userProfileToFHIR.call(void 0, userProfile);
   const entries = interventions.map((intervention) => {
     const isMedication = intervention.type === "medication" || intervention.type === "supplement";
     const resource = isMedication ? interventionToFHIRMedicationStatement(intervention, patientId) : interventionToFHIRObservation(intervention, patientId);
-    return { fullUrl: _chunkNKDUVSDKcjs.entryFullUrl.call(void 0, resource), resource };
+    return { fullUrl: _chunkWKTDMR5Pcjs.entryFullUrl.call(void 0, resource), resource };
   });
   return {
-    entry: [{ fullUrl: _chunkNKDUVSDKcjs.entryFullUrl.call(void 0, fhirPatient), resource: fhirPatient }, ...entries],
+    entry: [{ fullUrl: _chunkWKTDMR5Pcjs.entryFullUrl.call(void 0, fhirPatient), resource: fhirPatient }, ...entries],
     resourceType: "Bundle",
     type: "collection"
   };
@@ -752,5 +753,6 @@ var specimenTypeCoding = (text) => BY_NORMALIZED_TEXT.get(normalize(text));
 
 
 
-exports.AGE_BRACKETS = AGE_BRACKETS; exports.BIOMARKER_CODE_SYSTEM = _chunkOR67NJDZcjs.BIOMARKER_CODE_SYSTEM; exports.BIOMARKER_DEFAULT_UNIT = _chunk5RC7C7HJcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_DEFINITIONS = _chunkT75NZM56cjs.BIOMARKER_DEFINITIONS; exports.BIOMARKER_UNITS = _chunk5RC7C7HJcjs.BIOMARKER_UNITS; exports.BODY_FAT_ZONES = BODY_FAT_ZONES; exports.BR_TIPO_AMOSTRA_VALUESET = BR_TIPO_AMOSTRA_VALUESET; exports.BUNDLE_BASE_URL = _chunkNKDUVSDKcjs.BUNDLE_BASE_URL; exports.CAC_INDICATOR_CODES = _chunkT75NZM56cjs.CAC_INDICATOR_CODES; exports.CATEGORY_GROUPS = CATEGORY_GROUPS; exports.CATEGORY_SCREENING_INTERVALS = CATEGORY_SCREENING_INTERVALS; exports.DEXA_CATEGORIES = _chunkT75NZM56cjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkT75NZM56cjs.DEXA_INDICATOR_CODES; exports.FHIR_BRASIL_EXTENSIONS = FHIR_BRASIL_EXTENSIONS; exports.HL7_SPECIMEN_TYPE_SYSTEM = HL7_SPECIMEN_TYPE_SYSTEM; exports.IG_CANONICAL = IG_CANONICAL; exports.LOINC_SYSTEM = _chunkOR67NJDZcjs.LOINC_SYSTEM; exports.MAX_FILE_SIZE = _chunk376KM7ILcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunk376KM7ILcjs.MAX_OBSERVATIONS; exports.SOURCE_REGISTRY = _chunk5FMR2U7Pcjs.SOURCE_REGISTRY; exports.T_SCORE_ZONES = T_SCORE_ZONES; exports.UNIT_TO_UCUM = _chunk5RC7C7HJcjs.UNIT_TO_UCUM; exports.ZONE_DEFS = ZONE_DEFS; exports.applyFallbackReferenceRanges = _chunkVKLWTTUOcjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkVKLWTTUOcjs.biomarkerRangeDefinitions; exports.calculateNextScreeningDate = calculateNextScreeningDate; exports.cnsToFHIRIdentifier = cnsToFHIRIdentifier; exports.codeToLoinc = _chunkT75NZM56cjs.codeToLoinc; exports.convertUnit = _chunk5RC7C7HJcjs.convertUnit; exports.cpfToFHIRIdentifier = cpfToFHIRIdentifier; exports.defaultReferenceRanges = _chunkVKLWTTUOcjs.defaultReferenceRanges; exports.entryFullUrl = _chunkNKDUVSDKcjs.entryFullUrl; exports.extractObservationsFromBundle = _chunk376KM7ILcjs.extractObservationsFromBundle; exports.extractSourceKey = _chunk5FMR2U7Pcjs.extractSourceKey; exports.filterVisibleBiomarkers = _chunkT75NZM56cjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkT75NZM56cjs.findCodeByName; exports.flagAgainstCatalogRange = _chunkVKLWTTUOcjs.flagAgainstCatalogRange; exports.formatCNS = formatCNS; exports.formatCPF = formatCPF; exports.generateCacFullReference = _chunkT75NZM56cjs.generateCacFullReference; exports.generateDexaFullReference = _chunkT75NZM56cjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkT75NZM56cjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkT75NZM56cjs.generateLLMReference; exports.getAllCodes = _chunkT75NZM56cjs.getAllCodes; exports.getAllDefinitions = _chunkT75NZM56cjs.getAllDefinitions; exports.getAllLoincCodes = _chunkT75NZM56cjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkT75NZM56cjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkT75NZM56cjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkT75NZM56cjs.getBiomarkersForCategories; exports.getCanonicalUnit = _chunk5RC7C7HJcjs.getCanonicalUnit; exports.getCategoriesByInterval = getCategoriesByInterval; exports.getCategoryGroup = getCategoryGroup; exports.getDaysUntilScreening = getDaysUntilScreening; exports.getDefaultUnit = _chunk5RC7C7HJcjs.getDefaultUnit; exports.getDefinitionByCode = _chunkT75NZM56cjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkT75NZM56cjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkT75NZM56cjs.getDefinitionsBySex; exports.getDueCategories = getDueCategories; exports.getFallbackReferenceRange = _chunkVKLWTTUOcjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkVKLWTTUOcjs.getRangeDirection; exports.getReferenceRange = _chunkVKLWTTUOcjs.getReferenceRange; exports.getSIUnit = _chunk5RC7C7HJcjs.getSIUnit; exports.getScreeningInterval = getScreeningInterval; exports.getSexForCode = _chunkT75NZM56cjs.getSexForCode; exports.getVisibleDefinitions = _chunkT75NZM56cjs.getVisibleDefinitions; exports.interventionToFHIRMedicationStatement = interventionToFHIRMedicationStatement; exports.interventionToFHIRObservation = interventionToFHIRObservation; exports.interventionsToFHIRBundle = interventionsToFHIRBundle; exports.isBiomarkerVisible = _chunkT75NZM56cjs.isBiomarkerVisible; exports.isCacDocument = _chunkT75NZM56cjs.isCacDocument; exports.isDexaDocument = _chunkT75NZM56cjs.isDexaDocument; exports.isScreeningDue = isScreeningDue; exports.isUcumCode = _chunk5RC7C7HJcjs.isUcumCode; exports.isValidCode = _chunkT75NZM56cjs.isValidCode; exports.isValidLoinc = _chunkT75NZM56cjs.isValidLoinc; exports.labObservationToFHIR = _chunkNKDUVSDKcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkNKDUVSDKcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkNKDUVSDKcjs.labResultToFHIRBundle; exports.listMappedSubcategories = listMappedSubcategories; exports.loincToCode = _chunkT75NZM56cjs.loincToCode; exports.mapFHIRObservationToInternal = _chunk376KM7ILcjs.mapFHIRObservationToInternal; exports.normalizeCode = _chunkT75NZM56cjs.normalizeCode; exports.plural = plural; exports.pluralCount = pluralCount; exports.pluralPhrase = pluralPhrase; exports.pluralPhraseCount = pluralPhraseCount; exports.processImportBundle = _chunk376KM7ILcjs.processImportBundle; exports.referenceRangeMeaning = _chunkVKLWTTUOcjs.referenceRangeMeaning; exports.resolveUcum = _chunk5RC7C7HJcjs.resolveUcum; exports.specimenTypeCoding = specimenTypeCoding; exports.toBiomarkerTests = _chunkT75NZM56cjs.toBiomarkerTests; exports.unitToUCUM = _chunk5RC7C7HJcjs.unitToUCUM; exports.userProfileToFHIR = _chunkNKDUVSDKcjs.userProfileToFHIR; exports.validateCNS = validateCNS; exports.validateCPF = validateCPF; exports.validateFHIRDiagnosticReport = _chunkOAFAERDYcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunkOAFAERDYcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunkOAFAERDYcjs.validateFHIRObservation; exports.validateLoincNameMatch = _chunkT75NZM56cjs.validateLoincNameMatch;
+
+exports.AGE_BRACKETS = AGE_BRACKETS; exports.BIOMARKER_CODE_SYSTEM = _chunkOR67NJDZcjs.BIOMARKER_CODE_SYSTEM; exports.BIOMARKER_DEFAULT_UNIT = _chunkAQTHAZLKcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_DEFINITIONS = _chunkJES2ZLH5cjs.BIOMARKER_DEFINITIONS; exports.BIOMARKER_UNITS = _chunkAQTHAZLKcjs.BIOMARKER_UNITS; exports.BODY_FAT_ZONES = BODY_FAT_ZONES; exports.BR_TIPO_AMOSTRA_VALUESET = BR_TIPO_AMOSTRA_VALUESET; exports.BUNDLE_BASE_URL = _chunkWKTDMR5Pcjs.BUNDLE_BASE_URL; exports.CAC_INDICATOR_CODES = _chunkJES2ZLH5cjs.CAC_INDICATOR_CODES; exports.CATEGORY_GROUPS = CATEGORY_GROUPS; exports.CATEGORY_SCREENING_INTERVALS = CATEGORY_SCREENING_INTERVALS; exports.DEXA_CATEGORIES = _chunkJES2ZLH5cjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkJES2ZLH5cjs.DEXA_INDICATOR_CODES; exports.FHIR_BRASIL_EXTENSIONS = FHIR_BRASIL_EXTENSIONS; exports.HL7_SPECIMEN_TYPE_SYSTEM = HL7_SPECIMEN_TYPE_SYSTEM; exports.IG_CANONICAL = IG_CANONICAL; exports.LOINC_SYSTEM = _chunkOR67NJDZcjs.LOINC_SYSTEM; exports.MAX_FILE_SIZE = _chunkF7CC4SV5cjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkF7CC4SV5cjs.MAX_OBSERVATIONS; exports.SOURCE_REGISTRY = _chunk5FMR2U7Pcjs.SOURCE_REGISTRY; exports.T_SCORE_ZONES = T_SCORE_ZONES; exports.UNIT_TO_UCUM = _chunkAQTHAZLKcjs.UNIT_TO_UCUM; exports.ZONE_DEFS = ZONE_DEFS; exports.applyFallbackReferenceRanges = _chunkH64L6SOVcjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkH64L6SOVcjs.biomarkerRangeDefinitions; exports.calculateNextScreeningDate = calculateNextScreeningDate; exports.cnsToFHIRIdentifier = cnsToFHIRIdentifier; exports.codeToLoinc = _chunkJES2ZLH5cjs.codeToLoinc; exports.convertUnit = _chunkAQTHAZLKcjs.convertUnit; exports.cpfToFHIRIdentifier = cpfToFHIRIdentifier; exports.defaultReferenceRanges = _chunkH64L6SOVcjs.defaultReferenceRanges; exports.entryFullUrl = _chunkWKTDMR5Pcjs.entryFullUrl; exports.extractObservationsFromBundle = _chunkF7CC4SV5cjs.extractObservationsFromBundle; exports.extractSourceKey = _chunk5FMR2U7Pcjs.extractSourceKey; exports.filterVisibleBiomarkers = _chunkJES2ZLH5cjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkJES2ZLH5cjs.findCodeByName; exports.flagAgainstCatalogRange = _chunkH64L6SOVcjs.flagAgainstCatalogRange; exports.formatCNS = formatCNS; exports.formatCPF = formatCPF; exports.generateCacFullReference = _chunkJES2ZLH5cjs.generateCacFullReference; exports.generateDexaFullReference = _chunkJES2ZLH5cjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkJES2ZLH5cjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkJES2ZLH5cjs.generateLLMReference; exports.getAllCodes = _chunkJES2ZLH5cjs.getAllCodes; exports.getAllDefinitions = _chunkJES2ZLH5cjs.getAllDefinitions; exports.getAllLoincCodes = _chunkJES2ZLH5cjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkJES2ZLH5cjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkJES2ZLH5cjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkJES2ZLH5cjs.getBiomarkersForCategories; exports.getCanonicalUnit = _chunkAQTHAZLKcjs.getCanonicalUnit; exports.getCategoriesByInterval = getCategoriesByInterval; exports.getCategoryGroup = getCategoryGroup; exports.getDaysUntilScreening = getDaysUntilScreening; exports.getDefaultUnit = _chunkAQTHAZLKcjs.getDefaultUnit; exports.getDefinitionByCode = _chunkJES2ZLH5cjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkJES2ZLH5cjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkJES2ZLH5cjs.getDefinitionsBySex; exports.getDueCategories = getDueCategories; exports.getFallbackReferenceRange = _chunkH64L6SOVcjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkH64L6SOVcjs.getRangeDirection; exports.getReferenceRange = _chunkH64L6SOVcjs.getReferenceRange; exports.getSIUnit = _chunkAQTHAZLKcjs.getSIUnit; exports.getScreeningInterval = getScreeningInterval; exports.getSexForCode = _chunkJES2ZLH5cjs.getSexForCode; exports.getVisibleDefinitions = _chunkJES2ZLH5cjs.getVisibleDefinitions; exports.interventionToFHIRMedicationStatement = interventionToFHIRMedicationStatement; exports.interventionToFHIRObservation = interventionToFHIRObservation; exports.interventionsToFHIRBundle = interventionsToFHIRBundle; exports.isBiomarkerVisible = _chunkJES2ZLH5cjs.isBiomarkerVisible; exports.isCacDocument = _chunkJES2ZLH5cjs.isCacDocument; exports.isDexaDocument = _chunkJES2ZLH5cjs.isDexaDocument; exports.isScreeningDue = isScreeningDue; exports.isUcumCode = _chunkAQTHAZLKcjs.isUcumCode; exports.isValidCode = _chunkJES2ZLH5cjs.isValidCode; exports.isValidLoinc = _chunkJES2ZLH5cjs.isValidLoinc; exports.labObservationToFHIR = _chunkWKTDMR5Pcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkWKTDMR5Pcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkWKTDMR5Pcjs.labResultToFHIRBundle; exports.listMappedSubcategories = listMappedSubcategories; exports.loincToCode = _chunkJES2ZLH5cjs.loincToCode; exports.mapFHIRObservationToInternal = _chunkF7CC4SV5cjs.mapFHIRObservationToInternal; exports.methodVariantOf = _chunkJES2ZLH5cjs.methodVariantOf; exports.normalizeCode = _chunkJES2ZLH5cjs.normalizeCode; exports.plural = plural; exports.pluralCount = pluralCount; exports.pluralPhrase = pluralPhrase; exports.pluralPhraseCount = pluralPhraseCount; exports.processImportBundle = _chunkF7CC4SV5cjs.processImportBundle; exports.referenceRangeMeaning = _chunkH64L6SOVcjs.referenceRangeMeaning; exports.resolveUcum = _chunkAQTHAZLKcjs.resolveUcum; exports.specimenTypeCoding = specimenTypeCoding; exports.toBiomarkerTests = _chunkJES2ZLH5cjs.toBiomarkerTests; exports.unitToUCUM = _chunkAQTHAZLKcjs.unitToUCUM; exports.userProfileToFHIR = _chunkWKTDMR5Pcjs.userProfileToFHIR; exports.validateCNS = validateCNS; exports.validateCPF = validateCPF; exports.validateFHIRDiagnosticReport = _chunkRPGJK7ZMcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunkRPGJK7ZMcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunkRPGJK7ZMcjs.validateFHIRObservation; exports.validateLoincNameMatch = _chunkJES2ZLH5cjs.validateLoincNameMatch;
 //# sourceMappingURL=index.cjs.map