@precisa-saude/fhir 0.34.0 → 0.35.1

package/dist/biomarkers.cjs

@@ -30,8 +30,8 @@
 
 
 
-var _chunkT75NZM56cjs = require('./chunk-T75NZM56.cjs');
 
+var _chunkJES2ZLH5cjs = require('./chunk-JES2ZLH5.cjs');
 
 
 
@@ -63,5 +63,7 @@ var _chunkT75NZM56cjs = require('./chunk-T75NZM56.cjs');
 
 
 
-exports.BIOMARKER_DEFINITIONS = _chunkT75NZM56cjs.BIOMARKER_DEFINITIONS; exports.CAC_INDICATOR_CODES = _chunkT75NZM56cjs.CAC_INDICATOR_CODES; exports.DEXA_CATEGORIES = _chunkT75NZM56cjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkT75NZM56cjs.DEXA_INDICATOR_CODES; exports.codeToLoinc = _chunkT75NZM56cjs.codeToLoinc; exports.filterVisibleBiomarkers = _chunkT75NZM56cjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkT75NZM56cjs.findCodeByName; exports.generateCacFullReference = _chunkT75NZM56cjs.generateCacFullReference; exports.generateDexaFullReference = _chunkT75NZM56cjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkT75NZM56cjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkT75NZM56cjs.generateLLMReference; exports.getAllCodes = _chunkT75NZM56cjs.getAllCodes; exports.getAllDefinitions = _chunkT75NZM56cjs.getAllDefinitions; exports.getAllLoincCodes = _chunkT75NZM56cjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkT75NZM56cjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkT75NZM56cjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkT75NZM56cjs.getBiomarkersForCategories; exports.getDefinitionByCode = _chunkT75NZM56cjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkT75NZM56cjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkT75NZM56cjs.getDefinitionsBySex; exports.getSexForCode = _chunkT75NZM56cjs.getSexForCode; exports.getVisibleDefinitions = _chunkT75NZM56cjs.getVisibleDefinitions; exports.isBiomarkerVisible = _chunkT75NZM56cjs.isBiomarkerVisible; exports.isCacDocument = _chunkT75NZM56cjs.isCacDocument; exports.isDexaDocument = _chunkT75NZM56cjs.isDexaDocument; exports.isValidCode = _chunkT75NZM56cjs.isValidCode; exports.isValidLoinc = _chunkT75NZM56cjs.isValidLoinc; exports.loincToCode = _chunkT75NZM56cjs.loincToCode; exports.normalizeCode = _chunkT75NZM56cjs.normalizeCode; exports.toBiomarkerTests = _chunkT75NZM56cjs.toBiomarkerTests; exports.validateLoincNameMatch = _chunkT75NZM56cjs.validateLoincNameMatch;
+
+
+exports.BIOMARKER_DEFINITIONS = _chunkJES2ZLH5cjs.BIOMARKER_DEFINITIONS; exports.CAC_INDICATOR_CODES = _chunkJES2ZLH5cjs.CAC_INDICATOR_CODES; exports.DEXA_CATEGORIES = _chunkJES2ZLH5cjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkJES2ZLH5cjs.DEXA_INDICATOR_CODES; exports.codeToLoinc = _chunkJES2ZLH5cjs.codeToLoinc; exports.filterVisibleBiomarkers = _chunkJES2ZLH5cjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkJES2ZLH5cjs.findCodeByName; exports.generateCacFullReference = _chunkJES2ZLH5cjs.generateCacFullReference; exports.generateDexaFullReference = _chunkJES2ZLH5cjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkJES2ZLH5cjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkJES2ZLH5cjs.generateLLMReference; exports.getAllCodes = _chunkJES2ZLH5cjs.getAllCodes; exports.getAllDefinitions = _chunkJES2ZLH5cjs.getAllDefinitions; exports.getAllLoincCodes = _chunkJES2ZLH5cjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkJES2ZLH5cjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkJES2ZLH5cjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkJES2ZLH5cjs.getBiomarkersForCategories; exports.getDefinitionByCode = _chunkJES2ZLH5cjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkJES2ZLH5cjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkJES2ZLH5cjs.getDefinitionsBySex; exports.getSexForCode = _chunkJES2ZLH5cjs.getSexForCode; exports.getVisibleDefinitions = _chunkJES2ZLH5cjs.getVisibleDefinitions; exports.isBiomarkerVisible = _chunkJES2ZLH5cjs.isBiomarkerVisible; exports.isCacDocument = _chunkJES2ZLH5cjs.isCacDocument; exports.isDexaDocument = _chunkJES2ZLH5cjs.isDexaDocument; exports.isValidCode = _chunkJES2ZLH5cjs.isValidCode; exports.isValidLoinc = _chunkJES2ZLH5cjs.isValidLoinc; exports.loincToCode = _chunkJES2ZLH5cjs.loincToCode; exports.methodVariantOf = _chunkJES2ZLH5cjs.methodVariantOf; exports.normalizeCode = _chunkJES2ZLH5cjs.normalizeCode; exports.toBiomarkerTests = _chunkJES2ZLH5cjs.toBiomarkerTests; exports.validateLoincNameMatch = _chunkJES2ZLH5cjs.validateLoincNameMatch;
 //# sourceMappingURL=biomarkers.cjs.map

package/dist/biomarkers.cjs.map

@@ -1 +1 @@
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+{"version":3,"sources":["/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/biomarkers.cjs"],"names":[],"mappings":"AAAA;AACE;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACF,wDAA6B;AAC7B;AACE;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACF,mlEAAC","file":"/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/biomarkers.cjs"}

package/dist/biomarkers.d.cts

@@ -11,6 +11,30 @@
  * The LLM extraction prompt includes these definitions so it can output
  * LOINC codes directly, eliminating the need for name-matching logic.
  */
+/**
+ * Um código LOINC irmão do da entrada, que difere só no eixo Method.
+ *
+ * O `loinc` da entrada é o código sem método, e continua sendo o padrão: a
+ * variante só vale quando o laudo afirma o método por escrito. Separado de
+ * `loincAliases`, que quer dizer "código antigo para a mesma coisa".
+ */
+interface MethodVariant {
+    /**
+     * Trechos que afirmam o método, comparados por token inteiro como as grafias
+     * de `names`, na linha do exame e nas seguintes até o próximo exame. Só entra
+     * pista que aparece em laudo real; variante sem pista com evidência fica com
+     * as listas vazias e não é escolhida pela varredura.
+     */
+    cues: {
+        en: string[];
+        pt: string[];
+    };
+    loinc: string;
+    /** O texto da parte Method do LOINC, como o snapshot a registra. */
+    method: string;
+    /** Por que este código, e de onde veio a pista. */
+    note?: string;
+}
 interface BiomarkerDefinition {
     category: string | string[];
     code: string;
@@ -18,6 +42,8 @@ interface BiomarkerDefinition {
     hidden?: boolean;
     loinc?: string;
     loincAliases?: string[];
+    /** Ver `MethodVariant`. */
+    methodVariants?: MethodVariant[];
     names: {
         en: string[];
         pt: string[];
@@ -35,6 +61,13 @@ declare const BIOMARKER_DEFINITIONS: BiomarkerDefinition[];
  * Convert LOINC code to internal code
  */
 declare function loincToCode(loinc: string): string | undefined;
+/**
+ * A variante por método de um biomarcador, quando `loinc` é uma delas.
+ *
+ * Devolve `undefined` para o código sem método e para código que não é
+ * variante declarada daquele biomarcador.
+ */
+declare function methodVariantOf(code: string, loinc: string): MethodVariant | undefined;
 /**
  * Convert internal code to LOINC
  */
@@ -241,4 +274,4 @@ declare function getBiomarkersForCategories(categories: string[], options?: {
     sex?: 'male' | 'female' | 'both';
 }): Record<string, BiomarkerDefinition[]>;
 
-export { BIOMARKER_DEFINITIONS, type BiomarkerDefinition, type BiomarkerSearchPattern, CAC_INDICATOR_CODES, DEXA_CATEGORIES, DEXA_INDICATOR_CODES, type SupportedBiomarker, codeToLoinc, filterVisibleBiomarkers, findCodeByName, generateCacFullReference, generateDexaFullReference, generateFilteredLLMReference, generateLLMReference, getAllCodes, getAllDefinitions, getAllLoincCodes, getAllSearchPatterns, getBiomarkersByCategory, getBiomarkersForCategories, getDefinitionByCode, getDefinitionByLoinc, getDefinitionsBySex, getSexForCode, getVisibleDefinitions, isBiomarkerVisible, isCacDocument, isDexaDocument, isValidCode, isValidLoinc, loincToCode, normalizeCode, toBiomarkerTests, validateLoincNameMatch };
+export { BIOMARKER_DEFINITIONS, type BiomarkerDefinition, type BiomarkerSearchPattern, CAC_INDICATOR_CODES, DEXA_CATEGORIES, DEXA_INDICATOR_CODES, type MethodVariant, type SupportedBiomarker, codeToLoinc, filterVisibleBiomarkers, findCodeByName, generateCacFullReference, generateDexaFullReference, generateFilteredLLMReference, generateLLMReference, getAllCodes, getAllDefinitions, getAllLoincCodes, getAllSearchPatterns, getBiomarkersByCategory, getBiomarkersForCategories, getDefinitionByCode, getDefinitionByLoinc, getDefinitionsBySex, getSexForCode, getVisibleDefinitions, isBiomarkerVisible, isCacDocument, isDexaDocument, isValidCode, isValidLoinc, loincToCode, methodVariantOf, normalizeCode, toBiomarkerTests, validateLoincNameMatch };

package/dist/biomarkers.d.ts

@@ -11,6 +11,30 @@
  * The LLM extraction prompt includes these definitions so it can output
  * LOINC codes directly, eliminating the need for name-matching logic.
  */
+/**
+ * Um código LOINC irmão do da entrada, que difere só no eixo Method.
+ *
+ * O `loinc` da entrada é o código sem método, e continua sendo o padrão: a
+ * variante só vale quando o laudo afirma o método por escrito. Separado de
+ * `loincAliases`, que quer dizer "código antigo para a mesma coisa".
+ */
+interface MethodVariant {
+    /**
+     * Trechos que afirmam o método, comparados por token inteiro como as grafias
+     * de `names`, na linha do exame e nas seguintes até o próximo exame. Só entra
+     * pista que aparece em laudo real; variante sem pista com evidência fica com
+     * as listas vazias e não é escolhida pela varredura.
+     */
+    cues: {
+        en: string[];
+        pt: string[];
+    };
+    loinc: string;
+    /** O texto da parte Method do LOINC, como o snapshot a registra. */
+    method: string;
+    /** Por que este código, e de onde veio a pista. */
+    note?: string;
+}
 interface BiomarkerDefinition {
     category: string | string[];
     code: string;
@@ -18,6 +42,8 @@ interface BiomarkerDefinition {
     hidden?: boolean;
     loinc?: string;
     loincAliases?: string[];
+    /** Ver `MethodVariant`. */
+    methodVariants?: MethodVariant[];
     names: {
         en: string[];
         pt: string[];
@@ -35,6 +61,13 @@ declare const BIOMARKER_DEFINITIONS: BiomarkerDefinition[];
  * Convert LOINC code to internal code
  */
 declare function loincToCode(loinc: string): string | undefined;
+/**
+ * A variante por método de um biomarcador, quando `loinc` é uma delas.
+ *
+ * Devolve `undefined` para o código sem método e para código que não é
+ * variante declarada daquele biomarcador.
+ */
+declare function methodVariantOf(code: string, loinc: string): MethodVariant | undefined;
 /**
  * Convert internal code to LOINC
  */
@@ -241,4 +274,4 @@ declare function getBiomarkersForCategories(categories: string[], options?: {
     sex?: 'male' | 'female' | 'both';
 }): Record<string, BiomarkerDefinition[]>;
 
-export { BIOMARKER_DEFINITIONS, type BiomarkerDefinition, type BiomarkerSearchPattern, CAC_INDICATOR_CODES, DEXA_CATEGORIES, DEXA_INDICATOR_CODES, type SupportedBiomarker, codeToLoinc, filterVisibleBiomarkers, findCodeByName, generateCacFullReference, generateDexaFullReference, generateFilteredLLMReference, generateLLMReference, getAllCodes, getAllDefinitions, getAllLoincCodes, getAllSearchPatterns, getBiomarkersByCategory, getBiomarkersForCategories, getDefinitionByCode, getDefinitionByLoinc, getDefinitionsBySex, getSexForCode, getVisibleDefinitions, isBiomarkerVisible, isCacDocument, isDexaDocument, isValidCode, isValidLoinc, loincToCode, normalizeCode, toBiomarkerTests, validateLoincNameMatch };
+export { BIOMARKER_DEFINITIONS, type BiomarkerDefinition, type BiomarkerSearchPattern, CAC_INDICATOR_CODES, DEXA_CATEGORIES, DEXA_INDICATOR_CODES, type MethodVariant, type SupportedBiomarker, codeToLoinc, filterVisibleBiomarkers, findCodeByName, generateCacFullReference, generateDexaFullReference, generateFilteredLLMReference, generateLLMReference, getAllCodes, getAllDefinitions, getAllLoincCodes, getAllSearchPatterns, getBiomarkersByCategory, getBiomarkersForCategories, getDefinitionByCode, getDefinitionByLoinc, getDefinitionsBySex, getSexForCode, getVisibleDefinitions, isBiomarkerVisible, isCacDocument, isDexaDocument, isValidCode, isValidLoinc, loincToCode, methodVariantOf, normalizeCode, toBiomarkerTests, validateLoincNameMatch };

package/dist/biomarkers.js

@@ -27,10 +27,11 @@ import {
   isValidCode,
   isValidLoinc,
   loincToCode,
+  methodVariantOf,
   normalizeCode,
   toBiomarkerTests,
   validateLoincNameMatch
-} from "./chunk-4FKZG5GZ.js";
+} from "./chunk-KTV4H2QQ.js";
 export {
   BIOMARKER_DEFINITIONS,
   CAC_INDICATOR_CODES,
@@ -60,6 +61,7 @@ export {
   isValidCode,
   isValidLoinc,
   loincToCode,
+  methodVariantOf,
   normalizeCode,
   toBiomarkerTests,
   validateLoincNameMatch

package/dist/{chunk-NJM45WAH.js → chunk-3UCY4HPJ.js}

@@ -1,6 +1,6 @@
 import {
   validateFHIRImportBundle
-} from "./chunk-E6MXDQXW.js";
+} from "./chunk-YI5WYZCP.js";
 import {
   BIOMARKER_CODE_SYSTEM,
   LOINC_SYSTEM
@@ -10,8 +10,9 @@ import {
   getDefinitionByCode,
   isValidCode,
   loincToCode,
+  methodVariantOf,
   normalizeCode
-} from "./chunk-4FKZG5GZ.js";
+} from "./chunk-KTV4H2QQ.js";
 
 // src/importer.ts
 var MAX_OBSERVATIONS = 5e3;
@@ -124,6 +125,7 @@ function mapFHIRObservationToInternal(observation, index) {
     flag: extractFlag(observation),
     isQualitative,
     loincCode,
+    ...loincCode && methodVariantOf(internalCode, loincCode) && { methodLoinc: loincCode },
     ...referenceKind && { referenceKind },
     referenceMax,
     referenceMin,
@@ -169,4 +171,4 @@ export {
   mapFHIRObservationToInternal,
   processImportBundle
 };
-//# sourceMappingURL=chunk-NJM45WAH.js.map
+//# sourceMappingURL=chunk-3UCY4HPJ.js.map

package/dist/chunk-3UCY4HPJ.js.map

@@ -0,0 +1 @@
+{"version":3,"sources":["../src/importer.ts"],"sourcesContent":["/**\n * FHIR Importer\n *\n * Parses FHIR R4 Bundles and extracts Observation resources with known LOINC codes,\n * mapping them to internal biomarker codes for storage as lab results.\n */\n\nimport {\n  codeToLoinc,\n  getDefinitionByCode,\n  isValidCode,\n  loincToCode,\n  methodVariantOf,\n  normalizeCode,\n} from './biomarkers';\nimport { BIOMARKER_CODE_SYSTEM, LOINC_SYSTEM } from './code-systems';\nimport type { FHIRBundle, FHIRObservation } from './fhir-types';\nimport { validateFHIRImportBundle } from './validators';\n\nexport interface ImportedObservation {\n  biomarkerCode: string;\n  biomarkerName: string;\n  collectionDate: string;\n  flag: 'H' | 'L' | '';\n  isQualitative: boolean;\n  /** Ausente nos biomarcadores sem LOINC publicado, como composição corporal. */\n  loincCode?: string;\n  /** O `loincCode` quando ele é uma das variantes por método do biomarcador. */\n  methodLoinc?: string;\n  /** Lido do `referenceRange.type`, quando o Bundle o traz. */\n  referenceKind?: 'decision-threshold' | 'reference-interval';\n  referenceMax?: number;\n  referenceMin?: number;\n  unit: string;\n  value: number | string;\n}\n\nexport interface SkippedEntry {\n  index: number;\n  loincCode?: string;\n  reason: string;\n  resourceType?: string;\n}\n\nexport interface ImportError {\n  details: string;\n  field: string;\n}\n\nexport interface FHIRImportResult {\n  errors: ImportError[];\n  imported: ImportedObservation[];\n  skipped: SkippedEntry[];\n  totalProcessed: number;\n}\n\n/**\n * Limites de importação.\n *\n * Uma Observation exportada ocupa cerca de 1,25KB em JSON compacto e 2,75KB\n * quando o arquivo vem indentado, medido sobre um histórico real de 998\n * Observations em 61 laudos. Nesse tamanho, 5000 Observations dão 6,0MB\n * compactos ou 13,1MB indentados, e por isso o teto de arquivo é 15MB: cobre\n * as duas formas com folga.\n *\n * Na densidade desse mesmo histórico (16 Observations por laudo), 5000\n * equivalem a cerca de 300 laudos.\n */\nconst MAX_OBSERVATIONS = 5000;\nconst MAX_FILE_SIZE = 15 * 1024 * 1024; // 15MB\n\n/**\n * Resolve o código interno do biomarcador a partir do `code.coding`.\n *\n * LOINC primeiro, que é o vocabulário que arquivos de terceiros usam. Quando\n * não resolve, cai para o coding de códigos internos, presente nos arquivos\n * exportados pela própria plataforma.\n *\n * O fallback cobre dois casos: biomarcadores sem LOINC publicado (composição\n * corporal, densidade óssea, escore de cálcio) e arquivos antigos, exportados\n * quando esses biomarcadores saíam com o placeholder `99999-9`, que não\n * resolve para nada.\n */\nfunction resolveBiomarkerCode(observation: FHIRObservation): {\n  internalCode?: string;\n  loincCode?: string;\n  reason: string;\n} {\n  const coding = observation.code?.coding ?? [];\n  const loincCode = coding.find((c) => c.system === LOINC_SYSTEM)?.code;\n  const declaredCode = coding.find((c) => c.system === BIOMARKER_CODE_SYSTEM)?.code;\n\n  const seenCodes = [\n    ...(loincCode ? [`LOINC ${loincCode}`] : []),\n    ...(declaredCode ? [`biomarker code ${declaredCode}`] : []),\n  ];\n\n  // Três motivos distintos de descarte, que antes se confundiam num só. Sem\n  // essa separação, um arquivo em SNOMED relatava \"nenhum código encontrado\",\n  // sugerindo `coding` vazio quando na verdade o código existia e estava num\n  // system que não tratamos. Para importação de terceiros, é a diferença entre\n  // um diagnóstico acionável e um enigma.\n  let reason: string;\n  if (seenCodes.length > 0) {\n    reason = `Unknown code: ${seenCodes.join(', ')}`;\n  } else if (coding.length > 0) {\n    const systems = [...new Set(coding.map((c) => c.system ?? '(sem system)'))];\n    reason = `No code in a supported system (found: ${systems.join(', ')})`;\n  } else {\n    reason = 'No code found in observation coding';\n  }\n\n  const fromLoinc = loincCode ? loincToCode(loincCode) : undefined;\n  if (fromLoinc) return { internalCode: fromLoinc, loincCode, reason };\n\n  if (declaredCode && isValidCode(declaredCode)) {\n    // `isValidCode` aceita alias, mas alias não serve como código armazenado:\n    // 49 definições têm um, e tanto `codeToLoinc` quanto as faixas de\n    // referência são indexadas só pelo canônico. Sem normalizar, `VLDL_Cholesterol`\n    // entraria no lugar de `VLDL` e perderia o LOINC 13458-5 que ele tem.\n    // Importar um Bundle é fronteira de dados, que é onde `normalizeCode` deve\n    // ser aplicado.\n    const canonical = normalizeCode(declaredCode);\n\n    // `codeToLoinc` devolve undefined para quem não tem LOINC, que é o caso\n    // esperado aqui. O campo fica de fora em vez de receber um valor inventado.\n    return { internalCode: canonical, loincCode: codeToLoinc(canonical), reason };\n  }\n\n  return { loincCode, reason };\n}\n\n/**\n * Extract interpretation flag from Observation\n */\nfunction extractFlag(observation: FHIRObservation): 'H' | 'L' | '' {\n  const code = observation.interpretation?.[0]?.coding?.[0]?.code;\n  if (code === 'H' || code === 'HH') return 'H';\n  if (code === 'L' || code === 'LL') return 'L';\n  return '';\n}\n\n/**\n * Extract Observation resources from a FHIR Bundle\n */\nexport function extractObservationsFromBundle(bundle: FHIRBundle): {\n  observations: FHIRObservation[];\n  skipped: SkippedEntry[];\n} {\n  const observations: FHIRObservation[] = [];\n  const skipped: SkippedEntry[] = [];\n\n  for (let i = 0; i < bundle.entry.length; i++) {\n    const entry = bundle.entry[i]!;\n    if (!entry.resource) {\n      skipped.push({ index: i, reason: 'Entry has no resource' });\n      continue;\n    }\n\n    if (entry.resource.resourceType !== 'Observation') {\n      // Non-observation resources are silently skipped (Patient, DiagnosticReport, etc.)\n      continue;\n    }\n\n    if (observations.length >= MAX_OBSERVATIONS) {\n      skipped.push({ index: i, reason: `Maximum of ${MAX_OBSERVATIONS} observations exceeded` });\n      continue;\n    }\n\n    observations.push(entry.resource as FHIRObservation);\n  }\n\n  return { observations, skipped };\n}\n\n/**\n * Map a FHIR Observation to internal format using LOINC→biomarker code lookup\n */\nexport function mapFHIRObservationToInternal(\n  observation: FHIRObservation,\n  index: number,\n): { observation: ImportedObservation } | { skipped: SkippedEntry } {\n  const { internalCode, loincCode, reason } = resolveBiomarkerCode(observation);\n\n  if (!internalCode) {\n    return {\n      skipped: { index, loincCode, reason, resourceType: 'Observation' },\n    };\n  }\n\n  const definition = getDefinitionByCode(internalCode);\n\n  // Extract value\n  let value: number | string;\n  let unit = '';\n  let isQualitative = false;\n\n  if (observation.valueQuantity?.value !== undefined) {\n    value = observation.valueQuantity.value;\n    unit = observation.valueQuantity.unit || observation.valueQuantity.code || '';\n  } else if (observation.valueString) {\n    value = observation.valueString;\n    isQualitative = true;\n  } else {\n    return {\n      skipped: {\n        index,\n        loincCode,\n        reason: 'Observation has no value (valueQuantity or valueString)',\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  // Extract collection date (effectiveDateTime or effectivePeriod.start)\n  const collectionDate = observation.effectiveDateTime || observation.effectivePeriod?.start || '';\n  if (!collectionDate) {\n    return {\n      skipped: {\n        index,\n        loincCode,\n        reason: 'Observation has no effectiveDateTime or effectivePeriod.start',\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  // Extract reference ranges\n  let referenceMin: number | undefined;\n  let referenceMax: number | undefined;\n  let referenceKind: ImportedObservation['referenceKind'];\n  if (observation.referenceRange?.[0]) {\n    referenceMin = observation.referenceRange[0].low?.value;\n    referenceMax = observation.referenceRange[0].high?.value;\n    const meaning = observation.referenceRange[0].type?.coding?.find(\n      (c) => c.system === 'http://terminology.hl7.org/CodeSystem/referencerange-meaning',\n    )?.code;\n    if (meaning === 'normal') referenceKind = 'reference-interval';\n    else if (meaning === 'recommended') referenceKind = 'decision-threshold';\n  }\n\n  const imported: ImportedObservation = {\n    biomarkerCode: internalCode,\n    biomarkerName:\n      definition?.names.pt[0] || definition?.names.en[0] || observation.code.text || internalCode,\n    collectionDate,\n    flag: extractFlag(observation),\n    isQualitative,\n    loincCode,\n    ...(loincCode && methodVariantOf(internalCode, loincCode) && { methodLoinc: loincCode }),\n    ...(referenceKind && { referenceKind }),\n    referenceMax,\n    referenceMin,\n    unit: unit || definition?.unit || '',\n    value,\n  };\n\n  return { observation: imported };\n}\n\n/**\n * Process a complete FHIR Bundle for import\n */\nexport function processImportBundle(data: unknown): FHIRImportResult {\n  // Structural validation\n  const validationErrors = validateFHIRImportBundle(data);\n  if (validationErrors.length > 0) {\n    return {\n      errors: validationErrors,\n      imported: [],\n      skipped: [],\n      totalProcessed: 0,\n    };\n  }\n\n  const bundle = data as FHIRBundle;\n\n  // Extract observations\n  const { observations, skipped } = extractObservationsFromBundle(bundle);\n\n  // Map each observation to internal format\n  const imported: ImportedObservation[] = [];\n  const allSkipped: SkippedEntry[] = [...skipped];\n\n  for (let i = 0; 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package/dist/{chunk-P4G534AQ.js → chunk-7TDZX5HO.js}

@@ -1,6 +1,6 @@
 import {
   getCanonicalUnit
-} from "./chunk-Q3H5C6UR.js";
+} from "./chunk-LWSKO7UV.js";
 
 // src/reference-ranges.ts
 var biomarkerRangeDefinitions = {
@@ -455,10 +455,15 @@ var biomarkerRangeDefinitions = {
   // representada por zonas verde/amarela. Em pacientes > 50 anos,
   // diretrizes (ESC 2019, ACEP) recomendam corte ajustado pela idade:
   // idade × 10 ng/mL (até 750 ng/mL aos 75+).
+  //
+  // Todos os valores são em FEU (unidades equivalentes de fibrinogênio), e o
+  // código do catálogo é o do FEU (48065-7). Em DDU os cortes caem pela
+  // metade; não existe faixa DDU aqui.
   DDimer: {
     default: { max: 500, min: 0, unit: "ng/mL" },
     direction: "lower-better",
     kind: "decision-threshold",
+    loinc: "48065-7",
     source: "wells-ddimer-2003",
     variants: [
       // Corte ajustado por idade — ESC 2019 (Konstantinides et al.) e
@@ -1104,6 +1109,7 @@ var biomarkerRangeDefinitions = {
     default: { max: 125, min: 0, optimalMax: 75, optimalMin: 0, unit: "nmol/L" },
     direction: "lower-better",
     kind: "decision-threshold",
+    loinc: "43583-4",
     source: "sbc-lipids-2025"
   },
   // `Lymphocytes` (%) fica sem faixa de propósito e `Lymphocytes_Abs` usa os limites da
@@ -1570,6 +1576,7 @@ var biomarkerRangeDefinitions = {
   TroponinI: {
     default: { max: 0.04, min: 0, optimalMax: 0.02, optimalMin: 0, unit: "ng/mL" },
     kind: "reference-interval",
+    loinc: "49563-0",
     source: "keller-tni-2013"
   },
   // TroponinT: 14 ng/L = percentil 99 hs-cTnT (ensaio Roche Elecsys 5ª geração)
@@ -2422,4 +2429,4 @@ export {
   getFallbackReferenceRange,
   applyFallbackReferenceRanges
 };
-//# sourceMappingURL=chunk-P4G534AQ.js.map
+//# sourceMappingURL=chunk-7TDZX5HO.js.map