@precisa-saude/fhir 0.34.0 → 0.35.0

package/dist/cli.js

@@ -115,6 +115,32 @@ var BIOMARKER_DEFINITIONS = [
     category: "coracao",
     code: "LDL",
     loinc: "2089-1",
+    // Os três irmãos de 2089-1 no eixo Method, conferidos ativos em out/2026.
+    // Medido em três dezenas de laudos reais, a única pista escrita foi a
+    // nota de rodapé de um laboratório norte-americano que declara o cálculo de
+    // Martin-Hopkins. Nenhum laudo brasileiro do corpus imprimiu "calculado",
+    // "direto" ou "Método:" perto do LDL, e por isso as outras duas variantes
+    // ficam sem pista até aparecer laudo que as afirme.
+    methodVariants: [
+      {
+        cues: { en: ["calculated using the Martin-Hopkins"], pt: [] },
+        loinc: "96259-7",
+        method: "Calculated.Martin-Hopkins",
+        note: 'Rodap\xE9 "LDL-C is now calculated using the Martin-Hopkins calculation", que menciona Friedewald s\xF3 para comparar. Por isso a pista \xE9 a frase afirmativa, e n\xE3o o nome do m\xE9todo.'
+      },
+      {
+        cues: { en: [], pt: [] },
+        loinc: "13457-7",
+        method: "Calculated",
+        note: "Friedewald. Sem pista: nenhum laudo do corpus afirmou o c\xE1lculo por escrito."
+      },
+      {
+        cues: { en: [], pt: [] },
+        loinc: "18262-6",
+        method: "Direct assay",
+        note: "Dosagem direta. Sem pista: nenhum laudo do corpus afirmou o m\xE9todo por escrito."
+      }
+    ],
     names: {
       en: ["LDL Cholesterol", "LDL", "Low-Density Lipoprotein"],
       pt: ["Colesterol LDL", "LDL", "LDL-Colesterol"]
@@ -3313,6 +3339,10 @@ for (const def of BIOMARKER_DEFINITIONS) {
       validLoincSet.add(alias);
     }
   }
+  for (const variant of def.methodVariants ?? []) {
+    loincToCodeMap.set(variant.loinc, def.code);
+    validLoincSet.add(variant.loinc);
+  }
   if (def.codeAliases) {
     for (const alias of def.codeAliases) {
       codeAliasToCanonicalMap.set(alias, def.code);
@@ -3324,6 +3354,9 @@ for (const def of BIOMARKER_DEFINITIONS) {
 function loincToCode(loinc) {
   return loincToCodeMap.get(loinc);
 }
+function methodVariantOf(code, loinc) {
+  return codeToDefinitionMap.get(code)?.methodVariants?.find((v) => v.loinc === loinc);
+}
 function codeToLoinc(code) {
   return codeToLoincMap.get(code);
 }
@@ -6831,7 +6864,8 @@ var buildReferenceRanges = (observation, quantity) => {
   );
 };
 function labObservationToFHIR(observation, patientId, laboratoryName) {
-  const loincCode = codeToLoinc(observation.biomarkerCode);
+  const methodLoinc = observation.methodLoinc && methodVariantOf(observation.biomarkerCode, observation.methodLoinc) ? observation.methodLoinc : void 0;
+  const loincCode = methodLoinc ?? codeToLoinc(observation.biomarkerCode);
   const sourceUnit = observation.unit || getDefaultUnit(observation.biomarkerCode) || observation.unit;
   const ucumUnit = resolveUcum(sourceUnit, observation.biomarkerCode);
   const quantity = (value) => ({
@@ -7179,6 +7213,7 @@ function mapFHIRObservationToInternal(observation, index) {
     flag: extractFlag(observation),
     isQualitative,
     loincCode,
+    ...loincCode && methodVariantOf(internalCode, loincCode) && { methodLoinc: loincCode },
     ...referenceKind && { referenceKind },
     referenceMax,
     referenceMin,
@@ -7877,7 +7912,7 @@ var COMMANDS = {
 async function main() {
   const { command, help, json, resto, version } = dividirArgv(process.argv.slice(2));
   if (version) {
-    process.stdout.write(`${"0.34.0"}
+    process.stdout.write(`${"0.35.0"}
 `);
     return;
   }

package/dist/{converter-UygMzWlL.d.ts → converter-CTj83kPz.d.ts}

@@ -101,6 +101,12 @@ interface LabObservationData {
     collectionDate?: string;
     flag: Flag;
     isQualitative?: boolean;
+    /**
+     * O LOINC por método, quando o laudo afirmou o método por escrito. Só vale
+     * se for uma das `methodVariants` declaradas para o biomarcador; qualquer
+     * outro valor é ignorado e sai o código sem método.
+     */
+    methodLoinc?: string;
     /**
      * Tipo da faixa simples (`referenceMin`/`referenceMax`), quando quem chama
      * sabe. Sai como `referenceRange.type`. Faixa impressa pelo laboratório

package/dist/{converter-DP8VkkO3.d.cts → converter-Dlwb6OfB.d.cts}

@@ -101,6 +101,12 @@ interface LabObservationData {
     collectionDate?: string;
     flag: Flag;
     isQualitative?: boolean;
+    /**
+     * O LOINC por método, quando o laudo afirmou o método por escrito. Só vale
+     * se for uma das `methodVariants` declaradas para o biomarcador; qualquer
+     * outro valor é ignorado e sai o código sem método.
+     */
+    methodLoinc?: string;
     /**
      * Tipo da faixa simples (`referenceMin`/`referenceMax`), quando quem chama
      * sabe. Sai como `referenceRange.type`. Faixa impressa pelo laboratório

package/dist/converter.cjs

@@ -3,15 +3,15 @@
 
 
 
-var _chunkNKDUVSDKcjs = require('./chunk-NKDUVSDK.cjs');
+var _chunkXAIIZLZ7cjs = require('./chunk-XAIIZLZ7.cjs');
 require('./chunk-OR67NJDZ.cjs');
-require('./chunk-VKLWTTUO.cjs');
-require('./chunk-5RC7C7HJ.cjs');
-require('./chunk-T75NZM56.cjs');
+require('./chunk-HZSW5T7E.cjs');
+require('./chunk-LNL5QSHP.cjs');
+require('./chunk-YL65SZ6S.cjs');
 
 
 
 
 
-exports.labObservationToFHIR = _chunkNKDUVSDKcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkNKDUVSDKcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkNKDUVSDKcjs.labResultToFHIRBundle; exports.userProfileToFHIR = _chunkNKDUVSDKcjs.userProfileToFHIR;
+exports.labObservationToFHIR = _chunkXAIIZLZ7cjs.labObservationToFHIR; exports.labReportToFHIR = _chunkXAIIZLZ7cjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkXAIIZLZ7cjs.labResultToFHIRBundle; exports.userProfileToFHIR = _chunkXAIIZLZ7cjs.userProfileToFHIR;
 //# sourceMappingURL=converter.cjs.map

package/dist/converter.d.cts

@@ -1,3 +1,3 @@
-export { l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-DP8VkkO3.cjs';
+export { l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-Dlwb6OfB.cjs';
 export { e as FHIRAddress, f as FHIRAnnotation, g as FHIRAttachment, b as FHIRBundle, h as FHIRBundleEntry, i as FHIRCodeableConcept, d as FHIRCoding, j as FHIRContactPoint, k as FHIRDiagnosticReport, l as FHIRHumanName, c as FHIRIdentifier, F as FHIRMedicationStatement, a as FHIRObservation, m as FHIRPatient, n as FHIRPeriod, o as FHIRQuantity, p as FHIRReference, q as FHIRReferenceRange } from './fhir-types-Cn5WFbOI.cjs';
 import './reference-ranges.cjs';

package/dist/converter.d.ts

@@ -1,3 +1,3 @@
-export { l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-UygMzWlL.js';
+export { l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-CTj83kPz.js';
 export { e as FHIRAddress, f as FHIRAnnotation, g as FHIRAttachment, b as FHIRBundle, h as FHIRBundleEntry, i as FHIRCodeableConcept, d as FHIRCoding, j as FHIRContactPoint, k as FHIRDiagnosticReport, l as FHIRHumanName, c as FHIRIdentifier, F as FHIRMedicationStatement, a as FHIRObservation, m as FHIRPatient, n as FHIRPeriod, o as FHIRQuantity, p as FHIRReference, q as FHIRReferenceRange } from './fhir-types-Cn5WFbOI.js';
 import './reference-ranges.js';

package/dist/converter.js

@@ -3,11 +3,11 @@ import {
   labReportToFHIR,
   labResultToFHIRBundle,
   userProfileToFHIR
-} from "./chunk-K3VZ3F5Z.js";
+} from "./chunk-TLF3IVSN.js";
 import "./chunk-A6HR4XDK.js";
-import "./chunk-P4G534AQ.js";
-import "./chunk-Q3H5C6UR.js";
-import "./chunk-4FKZG5GZ.js";
+import "./chunk-O3FXUPW3.js";
+import "./chunk-U2XW6DY4.js";
+import "./chunk-KQ4CX67G.js";
 export {
   labObservationToFHIR,
   labReportToFHIR,

package/dist/importer.cjs

@@ -4,16 +4,16 @@
 
 
 
-var _chunk376KM7ILcjs = require('./chunk-376KM7IL.cjs');
-require('./chunk-OAFAERDY.cjs');
+var _chunk77LDD6OPcjs = require('./chunk-77LDD6OP.cjs');
+require('./chunk-VMYB7KOE.cjs');
 require('./chunk-OR67NJDZ.cjs');
-require('./chunk-5RC7C7HJ.cjs');
-require('./chunk-T75NZM56.cjs');
+require('./chunk-LNL5QSHP.cjs');
+require('./chunk-YL65SZ6S.cjs');
 
 
 
 
 
 
-exports.MAX_FILE_SIZE = _chunk376KM7ILcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunk376KM7ILcjs.MAX_OBSERVATIONS; exports.extractObservationsFromBundle = _chunk376KM7ILcjs.extractObservationsFromBundle; exports.mapFHIRObservationToInternal = _chunk376KM7ILcjs.mapFHIRObservationToInternal; exports.processImportBundle = _chunk376KM7ILcjs.processImportBundle;
+exports.MAX_FILE_SIZE = _chunk77LDD6OPcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunk77LDD6OPcjs.MAX_OBSERVATIONS; exports.extractObservationsFromBundle = _chunk77LDD6OPcjs.extractObservationsFromBundle; exports.mapFHIRObservationToInternal = _chunk77LDD6OPcjs.mapFHIRObservationToInternal; exports.processImportBundle = _chunk77LDD6OPcjs.processImportBundle;
 //# sourceMappingURL=importer.cjs.map

package/dist/importer.d.cts

@@ -15,6 +15,8 @@ interface ImportedObservation {
     isQualitative: boolean;
     /** Ausente nos biomarcadores sem LOINC publicado, como composição corporal. */
     loincCode?: string;
+    /** O `loincCode` quando ele é uma das variantes por método do biomarcador. */
+    methodLoinc?: string;
     /** Lido do `referenceRange.type`, quando o Bundle o traz. */
     referenceKind?: 'decision-threshold' | 'reference-interval';
     referenceMax?: number;

package/dist/importer.d.ts

@@ -15,6 +15,8 @@ interface ImportedObservation {
     isQualitative: boolean;
     /** Ausente nos biomarcadores sem LOINC publicado, como composição corporal. */
     loincCode?: string;
+    /** O `loincCode` quando ele é uma das variantes por método do biomarcador. */
+    methodLoinc?: string;
     /** Lido do `referenceRange.type`, quando o Bundle o traz. */
     referenceKind?: 'decision-threshold' | 'reference-interval';
     referenceMax?: number;

package/dist/importer.js

@@ -4,11 +4,11 @@ import {
   extractObservationsFromBundle,
   mapFHIRObservationToInternal,
   processImportBundle
-} from "./chunk-NJM45WAH.js";
-import "./chunk-E6MXDQXW.js";
+} from "./chunk-6QUGBBV2.js";
+import "./chunk-XT635TWP.js";
 import "./chunk-A6HR4XDK.js";
-import "./chunk-Q3H5C6UR.js";
-import "./chunk-4FKZG5GZ.js";
+import "./chunk-U2XW6DY4.js";
+import "./chunk-KQ4CX67G.js";
 export {
   MAX_FILE_SIZE,
   MAX_OBSERVATIONS,

package/dist/index.cjs

@@ -5,19 +5,19 @@
 
 
 
-var _chunkNKDUVSDKcjs = require('./chunk-NKDUVSDK.cjs');
+var _chunkXAIIZLZ7cjs = require('./chunk-XAIIZLZ7.cjs');
 
 
 
 
 
 
-var _chunk376KM7ILcjs = require('./chunk-376KM7IL.cjs');
+var _chunk77LDD6OPcjs = require('./chunk-77LDD6OP.cjs');
 
 
 
 
-var _chunkOAFAERDYcjs = require('./chunk-OAFAERDY.cjs');
+var _chunkVMYB7KOEcjs = require('./chunk-VMYB7KOE.cjs');
 
 
 
@@ -31,7 +31,7 @@ var _chunkOR67NJDZcjs = require('./chunk-OR67NJDZ.cjs');
 
 
 
-var _chunkVKLWTTUOcjs = require('./chunk-VKLWTTUO.cjs');
+var _chunkHZSW5T7Ecjs = require('./chunk-HZSW5T7E.cjs');
 
 
 
@@ -47,7 +47,7 @@ var _chunk5FMR2U7Pcjs = require('./chunk-5FMR2U7P.cjs');
 
 
 
-var _chunk5RC7C7HJcjs = require('./chunk-5RC7C7HJ.cjs');
+var _chunkLNL5QSHPcjs = require('./chunk-LNL5QSHP.cjs');
 
 
 
@@ -80,7 +80,8 @@ var _chunk5RC7C7HJcjs = require('./chunk-5RC7C7HJ.cjs');
 
 
 
-var _chunkT75NZM56cjs = require('./chunk-T75NZM56.cjs');
+
+var _chunkYL65SZ6Scjs = require('./chunk-YL65SZ6S.cjs');
 
 // src/category-groups.ts
 var CATEGORY_GROUPS = {
@@ -242,14 +243,14 @@ function interventionToFHIRObservation(intervention, patientId) {
 }
 function interventionsToFHIRBundle(interventions, userProfile) {
   const patientId = userProfile.userId;
-  const fhirPatient = _chunkNKDUVSDKcjs.userProfileToFHIR.call(void 0, userProfile);
+  const fhirPatient = _chunkXAIIZLZ7cjs.userProfileToFHIR.call(void 0, userProfile);
   const entries = interventions.map((intervention) => {
     const isMedication = intervention.type === "medication" || intervention.type === "supplement";
     const resource = isMedication ? interventionToFHIRMedicationStatement(intervention, patientId) : interventionToFHIRObservation(intervention, patientId);
-    return { fullUrl: _chunkNKDUVSDKcjs.entryFullUrl.call(void 0, resource), resource };
+    return { fullUrl: _chunkXAIIZLZ7cjs.entryFullUrl.call(void 0, resource), resource };
   });
   return {
-    entry: [{ fullUrl: _chunkNKDUVSDKcjs.entryFullUrl.call(void 0, fhirPatient), resource: fhirPatient }, ...entries],
+    entry: [{ fullUrl: _chunkXAIIZLZ7cjs.entryFullUrl.call(void 0, fhirPatient), resource: fhirPatient }, ...entries],
     resourceType: "Bundle",
     type: "collection"
   };
@@ -752,5 +753,6 @@ var specimenTypeCoding = (text) => BY_NORMALIZED_TEXT.get(normalize(text));
 
 
 
-exports.AGE_BRACKETS = AGE_BRACKETS; exports.BIOMARKER_CODE_SYSTEM = _chunkOR67NJDZcjs.BIOMARKER_CODE_SYSTEM; exports.BIOMARKER_DEFAULT_UNIT = _chunk5RC7C7HJcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_DEFINITIONS = _chunkT75NZM56cjs.BIOMARKER_DEFINITIONS; exports.BIOMARKER_UNITS = _chunk5RC7C7HJcjs.BIOMARKER_UNITS; exports.BODY_FAT_ZONES = BODY_FAT_ZONES; exports.BR_TIPO_AMOSTRA_VALUESET = BR_TIPO_AMOSTRA_VALUESET; exports.BUNDLE_BASE_URL = _chunkNKDUVSDKcjs.BUNDLE_BASE_URL; exports.CAC_INDICATOR_CODES = _chunkT75NZM56cjs.CAC_INDICATOR_CODES; exports.CATEGORY_GROUPS = CATEGORY_GROUPS; exports.CATEGORY_SCREENING_INTERVALS = CATEGORY_SCREENING_INTERVALS; exports.DEXA_CATEGORIES = _chunkT75NZM56cjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkT75NZM56cjs.DEXA_INDICATOR_CODES; exports.FHIR_BRASIL_EXTENSIONS = FHIR_BRASIL_EXTENSIONS; exports.HL7_SPECIMEN_TYPE_SYSTEM = HL7_SPECIMEN_TYPE_SYSTEM; exports.IG_CANONICAL = IG_CANONICAL; exports.LOINC_SYSTEM = _chunkOR67NJDZcjs.LOINC_SYSTEM; exports.MAX_FILE_SIZE = _chunk376KM7ILcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunk376KM7ILcjs.MAX_OBSERVATIONS; exports.SOURCE_REGISTRY = _chunk5FMR2U7Pcjs.SOURCE_REGISTRY; exports.T_SCORE_ZONES = T_SCORE_ZONES; exports.UNIT_TO_UCUM = _chunk5RC7C7HJcjs.UNIT_TO_UCUM; exports.ZONE_DEFS = ZONE_DEFS; exports.applyFallbackReferenceRanges = _chunkVKLWTTUOcjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkVKLWTTUOcjs.biomarkerRangeDefinitions; exports.calculateNextScreeningDate = calculateNextScreeningDate; exports.cnsToFHIRIdentifier = cnsToFHIRIdentifier; exports.codeToLoinc = _chunkT75NZM56cjs.codeToLoinc; exports.convertUnit = _chunk5RC7C7HJcjs.convertUnit; exports.cpfToFHIRIdentifier = cpfToFHIRIdentifier; exports.defaultReferenceRanges = _chunkVKLWTTUOcjs.defaultReferenceRanges; exports.entryFullUrl = _chunkNKDUVSDKcjs.entryFullUrl; exports.extractObservationsFromBundle = _chunk376KM7ILcjs.extractObservationsFromBundle; exports.extractSourceKey = _chunk5FMR2U7Pcjs.extractSourceKey; exports.filterVisibleBiomarkers = _chunkT75NZM56cjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkT75NZM56cjs.findCodeByName; exports.flagAgainstCatalogRange = _chunkVKLWTTUOcjs.flagAgainstCatalogRange; exports.formatCNS = formatCNS; exports.formatCPF = formatCPF; exports.generateCacFullReference = _chunkT75NZM56cjs.generateCacFullReference; exports.generateDexaFullReference = _chunkT75NZM56cjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkT75NZM56cjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkT75NZM56cjs.generateLLMReference; exports.getAllCodes = _chunkT75NZM56cjs.getAllCodes; exports.getAllDefinitions = _chunkT75NZM56cjs.getAllDefinitions; exports.getAllLoincCodes = _chunkT75NZM56cjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkT75NZM56cjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkT75NZM56cjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkT75NZM56cjs.getBiomarkersForCategories; exports.getCanonicalUnit = _chunk5RC7C7HJcjs.getCanonicalUnit; exports.getCategoriesByInterval = getCategoriesByInterval; exports.getCategoryGroup = getCategoryGroup; exports.getDaysUntilScreening = getDaysUntilScreening; exports.getDefaultUnit = _chunk5RC7C7HJcjs.getDefaultUnit; exports.getDefinitionByCode = _chunkT75NZM56cjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkT75NZM56cjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkT75NZM56cjs.getDefinitionsBySex; exports.getDueCategories = getDueCategories; exports.getFallbackReferenceRange = _chunkVKLWTTUOcjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkVKLWTTUOcjs.getRangeDirection; exports.getReferenceRange = _chunkVKLWTTUOcjs.getReferenceRange; exports.getSIUnit = _chunk5RC7C7HJcjs.getSIUnit; exports.getScreeningInterval = getScreeningInterval; exports.getSexForCode = _chunkT75NZM56cjs.getSexForCode; exports.getVisibleDefinitions = _chunkT75NZM56cjs.getVisibleDefinitions; exports.interventionToFHIRMedicationStatement = interventionToFHIRMedicationStatement; exports.interventionToFHIRObservation = interventionToFHIRObservation; exports.interventionsToFHIRBundle = interventionsToFHIRBundle; exports.isBiomarkerVisible = _chunkT75NZM56cjs.isBiomarkerVisible; exports.isCacDocument = _chunkT75NZM56cjs.isCacDocument; exports.isDexaDocument = _chunkT75NZM56cjs.isDexaDocument; exports.isScreeningDue = isScreeningDue; exports.isUcumCode = _chunk5RC7C7HJcjs.isUcumCode; exports.isValidCode = _chunkT75NZM56cjs.isValidCode; exports.isValidLoinc = _chunkT75NZM56cjs.isValidLoinc; exports.labObservationToFHIR = _chunkNKDUVSDKcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkNKDUVSDKcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkNKDUVSDKcjs.labResultToFHIRBundle; exports.listMappedSubcategories = listMappedSubcategories; exports.loincToCode = _chunkT75NZM56cjs.loincToCode; exports.mapFHIRObservationToInternal = _chunk376KM7ILcjs.mapFHIRObservationToInternal; exports.normalizeCode = _chunkT75NZM56cjs.normalizeCode; exports.plural = plural; exports.pluralCount = pluralCount; exports.pluralPhrase = pluralPhrase; exports.pluralPhraseCount = pluralPhraseCount; exports.processImportBundle = _chunk376KM7ILcjs.processImportBundle; exports.referenceRangeMeaning = _chunkVKLWTTUOcjs.referenceRangeMeaning; exports.resolveUcum = _chunk5RC7C7HJcjs.resolveUcum; exports.specimenTypeCoding = specimenTypeCoding; exports.toBiomarkerTests = _chunkT75NZM56cjs.toBiomarkerTests; exports.unitToUCUM = _chunk5RC7C7HJcjs.unitToUCUM; exports.userProfileToFHIR = _chunkNKDUVSDKcjs.userProfileToFHIR; exports.validateCNS = validateCNS; exports.validateCPF = validateCPF; exports.validateFHIRDiagnosticReport = _chunkOAFAERDYcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunkOAFAERDYcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunkOAFAERDYcjs.validateFHIRObservation; exports.validateLoincNameMatch = _chunkT75NZM56cjs.validateLoincNameMatch;
+
+exports.AGE_BRACKETS = AGE_BRACKETS; exports.BIOMARKER_CODE_SYSTEM = _chunkOR67NJDZcjs.BIOMARKER_CODE_SYSTEM; exports.BIOMARKER_DEFAULT_UNIT = _chunkLNL5QSHPcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_DEFINITIONS = _chunkYL65SZ6Scjs.BIOMARKER_DEFINITIONS; exports.BIOMARKER_UNITS = _chunkLNL5QSHPcjs.BIOMARKER_UNITS; exports.BODY_FAT_ZONES = BODY_FAT_ZONES; exports.BR_TIPO_AMOSTRA_VALUESET = BR_TIPO_AMOSTRA_VALUESET; exports.BUNDLE_BASE_URL = _chunkXAIIZLZ7cjs.BUNDLE_BASE_URL; exports.CAC_INDICATOR_CODES = _chunkYL65SZ6Scjs.CAC_INDICATOR_CODES; exports.CATEGORY_GROUPS = CATEGORY_GROUPS; exports.CATEGORY_SCREENING_INTERVALS = CATEGORY_SCREENING_INTERVALS; exports.DEXA_CATEGORIES = _chunkYL65SZ6Scjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkYL65SZ6Scjs.DEXA_INDICATOR_CODES; exports.FHIR_BRASIL_EXTENSIONS = FHIR_BRASIL_EXTENSIONS; exports.HL7_SPECIMEN_TYPE_SYSTEM = HL7_SPECIMEN_TYPE_SYSTEM; exports.IG_CANONICAL = IG_CANONICAL; exports.LOINC_SYSTEM = _chunkOR67NJDZcjs.LOINC_SYSTEM; exports.MAX_FILE_SIZE = _chunk77LDD6OPcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunk77LDD6OPcjs.MAX_OBSERVATIONS; exports.SOURCE_REGISTRY = _chunk5FMR2U7Pcjs.SOURCE_REGISTRY; exports.T_SCORE_ZONES = T_SCORE_ZONES; exports.UNIT_TO_UCUM = _chunkLNL5QSHPcjs.UNIT_TO_UCUM; exports.ZONE_DEFS = ZONE_DEFS; exports.applyFallbackReferenceRanges = _chunkHZSW5T7Ecjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkHZSW5T7Ecjs.biomarkerRangeDefinitions; exports.calculateNextScreeningDate = calculateNextScreeningDate; exports.cnsToFHIRIdentifier = cnsToFHIRIdentifier; exports.codeToLoinc = _chunkYL65SZ6Scjs.codeToLoinc; exports.convertUnit = _chunkLNL5QSHPcjs.convertUnit; exports.cpfToFHIRIdentifier = cpfToFHIRIdentifier; exports.defaultReferenceRanges = _chunkHZSW5T7Ecjs.defaultReferenceRanges; exports.entryFullUrl = _chunkXAIIZLZ7cjs.entryFullUrl; exports.extractObservationsFromBundle = _chunk77LDD6OPcjs.extractObservationsFromBundle; exports.extractSourceKey = _chunk5FMR2U7Pcjs.extractSourceKey; exports.filterVisibleBiomarkers = _chunkYL65SZ6Scjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkYL65SZ6Scjs.findCodeByName; exports.flagAgainstCatalogRange = _chunkHZSW5T7Ecjs.flagAgainstCatalogRange; exports.formatCNS = formatCNS; exports.formatCPF = formatCPF; exports.generateCacFullReference = _chunkYL65SZ6Scjs.generateCacFullReference; exports.generateDexaFullReference = _chunkYL65SZ6Scjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkYL65SZ6Scjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkYL65SZ6Scjs.generateLLMReference; exports.getAllCodes = _chunkYL65SZ6Scjs.getAllCodes; exports.getAllDefinitions = _chunkYL65SZ6Scjs.getAllDefinitions; exports.getAllLoincCodes = _chunkYL65SZ6Scjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkYL65SZ6Scjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkYL65SZ6Scjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkYL65SZ6Scjs.getBiomarkersForCategories; exports.getCanonicalUnit = _chunkLNL5QSHPcjs.getCanonicalUnit; exports.getCategoriesByInterval = getCategoriesByInterval; exports.getCategoryGroup = getCategoryGroup; exports.getDaysUntilScreening = getDaysUntilScreening; exports.getDefaultUnit = _chunkLNL5QSHPcjs.getDefaultUnit; exports.getDefinitionByCode = _chunkYL65SZ6Scjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkYL65SZ6Scjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkYL65SZ6Scjs.getDefinitionsBySex; exports.getDueCategories = getDueCategories; exports.getFallbackReferenceRange = _chunkHZSW5T7Ecjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkHZSW5T7Ecjs.getRangeDirection; exports.getReferenceRange = _chunkHZSW5T7Ecjs.getReferenceRange; exports.getSIUnit = _chunkLNL5QSHPcjs.getSIUnit; exports.getScreeningInterval = getScreeningInterval; exports.getSexForCode = _chunkYL65SZ6Scjs.getSexForCode; exports.getVisibleDefinitions = _chunkYL65SZ6Scjs.getVisibleDefinitions; exports.interventionToFHIRMedicationStatement = interventionToFHIRMedicationStatement; exports.interventionToFHIRObservation = interventionToFHIRObservation; exports.interventionsToFHIRBundle = interventionsToFHIRBundle; exports.isBiomarkerVisible = _chunkYL65SZ6Scjs.isBiomarkerVisible; exports.isCacDocument = _chunkYL65SZ6Scjs.isCacDocument; exports.isDexaDocument = _chunkYL65SZ6Scjs.isDexaDocument; exports.isScreeningDue = isScreeningDue; exports.isUcumCode = _chunkLNL5QSHPcjs.isUcumCode; exports.isValidCode = _chunkYL65SZ6Scjs.isValidCode; exports.isValidLoinc = _chunkYL65SZ6Scjs.isValidLoinc; exports.labObservationToFHIR = _chunkXAIIZLZ7cjs.labObservationToFHIR; exports.labReportToFHIR = _chunkXAIIZLZ7cjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkXAIIZLZ7cjs.labResultToFHIRBundle; exports.listMappedSubcategories = listMappedSubcategories; exports.loincToCode = _chunkYL65SZ6Scjs.loincToCode; exports.mapFHIRObservationToInternal = _chunk77LDD6OPcjs.mapFHIRObservationToInternal; exports.methodVariantOf = _chunkYL65SZ6Scjs.methodVariantOf; exports.normalizeCode = _chunkYL65SZ6Scjs.normalizeCode; exports.plural = plural; exports.pluralCount = pluralCount; exports.pluralPhrase = pluralPhrase; exports.pluralPhraseCount = pluralPhraseCount; exports.processImportBundle = _chunk77LDD6OPcjs.processImportBundle; exports.referenceRangeMeaning = _chunkHZSW5T7Ecjs.referenceRangeMeaning; exports.resolveUcum = _chunkLNL5QSHPcjs.resolveUcum; exports.specimenTypeCoding = specimenTypeCoding; exports.toBiomarkerTests = _chunkYL65SZ6Scjs.toBiomarkerTests; exports.unitToUCUM = _chunkLNL5QSHPcjs.unitToUCUM; exports.userProfileToFHIR = _chunkXAIIZLZ7cjs.userProfileToFHIR; exports.validateCNS = validateCNS; exports.validateCPF = validateCPF; exports.validateFHIRDiagnosticReport = _chunkVMYB7KOEcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunkVMYB7KOEcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunkVMYB7KOEcjs.validateFHIRObservation; exports.validateLoincNameMatch = _chunkYL65SZ6Scjs.validateLoincNameMatch;
 //# sourceMappingURL=index.cjs.map

package/dist/index.cjs.map

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* Agrupamento de categorias clínicas em 10 grupos de alto nível.\n *\n * `BiomarkerDefinition.category` armazena 20 sub-categorias (granularidade\n * fina, ex: `tireoide`, `pancreas`). Este módulo agrupa essas\n * sub-categorias em 10 buckets clínicos amplos para apresentação no\n * site, na API pública e em material de divulgação.\n *\n * As sub-categorias permanecem como fonte da verdade nos dados; este\n * agrupamento é uma camada derivada.\n */\n\nexport type CategoryGroup =\n  | 'cardiovascular'\n  | 'metabolico-endocrino'\n  | 'renal-eletrolitico'\n  | 'hepatico-biliar'\n  | 'hematologico'\n  | 'imunologico'\n  | 'oncologico'\n  | 'nutricional-ambiental'\n  | 'saude-reprodutiva'\n  | 'composicao-envelhecimento';\n\nexport interface CategoryGroupInfo {\n  /** Rótulo em inglês */\n  en: string;\n  /** Rótulo em português */\n  pt: string;\n  /** Slug (kebab-case, sem acento) */\n  slug: CategoryGroup;\n  /** Sub-categorias da fonte agrupadas neste bucket */\n  subcategories: readonly string[];\n}\n\nexport const CATEGORY_GROUPS: Record<CategoryGroup, CategoryGroupInfo> = {\n  cardiovascular: {\n    en: 'Cardiovascular',\n    pt: 'Cardiovascular',\n    slug: 'cardiovascular',\n    subcategories: ['coracao'],\n  },\n  'composicao-envelhecimento': {\n    en: 'Body Composition & Aging',\n    pt: 'Composição Corporal e Envelhecimento',\n    slug: 'composicao-envelhecimento',\n    subcategories: ['composicao-corporal', 'densidade-ossea', 'estresse-envelhecimento'],\n  },\n  hematologico: {\n    en: 'Hematology',\n    pt: 'Hematológico',\n    slug: 'hematologico',\n    subcategories: ['sangue'],\n  },\n  'hepatico-biliar': {\n    en: 'Hepatic & Biliary',\n    pt: 'Hepático e Biliar',\n    slug: 'hepatico-biliar',\n    subcategories: ['figado'],\n  },\n  imunologico: {\n    en: 'Immunology',\n    pt: 'Imunológico',\n    slug: 'imunologico',\n    subcategories: ['autoimunidade', 'regulacao-imunologica'],\n  },\n  'metabolico-endocrino': {\n    en: 'Metabolic & Endocrine',\n    pt: 'Metabólico e Endócrino',\n    slug: 'metabolico-endocrino',\n    subcategories: ['metabolico', 'pancreas', 'hormonios', 'tireoide'],\n  },\n  'nutricional-ambiental': {\n    en: 'Nutrition & Environmental Exposure',\n    pt: 'Nutricional e Exposição Ambiental',\n    slug: 'nutricional-ambiental',\n    subcategories: ['nutrientes', 'toxinas-ambientais'],\n  },\n  oncologico: {\n    en: 'Oncology',\n    pt: 'Oncológico',\n    slug: 'oncologico',\n    subcategories: ['marcadores-tumorais'],\n  },\n  'renal-eletrolitico': {\n    en: 'Renal & Electrolytes',\n    pt: 'Renal e Eletrolítico',\n    slug: 'renal-eletrolitico',\n    subcategories: ['rins', 'urina', 'eletrolitos'],\n  },\n  'saude-reprodutiva': {\n    en: 'Reproductive Health',\n    pt: 'Saúde Reprodutiva',\n    slug: 'saude-reprodutiva',\n    subcategories: ['saude-feminina', 'saude-masculina'],\n  },\n};\n\nconst SUBCATEGORY_TO_GROUP = new Map<string, CategoryGroup>();\nfor (const group of Object.values(CATEGORY_GROUPS)) {\n  for (const sub of group.subcategories) {\n    SUBCATEGORY_TO_GROUP.set(sub, group.slug);\n  }\n}\n\n/**\n * Resolve a sub-categoria (granular) para o grupo de alto nível (10 buckets).\n */\nexport function getCategoryGroup(subcategory: string): CategoryGroup | undefined {\n  return SUBCATEGORY_TO_GROUP.get(subcategory);\n}\n\n/**\n * Lista todas as sub-categorias mapeadas em algum grupo.\n */\nexport function listMappedSubcategories(): readonly string[] {\n  return [...SUBCATEGORY_TO_GROUP.keys()];\n}\n","/**\n * FHIR Intervention Converter\n *\n * Converts interventions (medication, supplement, diet, exercise, sleep)\n * to FHIR R4 MedicationStatement and Observation resources.\n */\n\nimport { type Addressable, entryFullUrl } from './bundle-urls';\nimport { userProfileToFHIR } from './converter';\nimport type { FHIRBundle, FHIRMedicationStatement, FHIRObservation } from './fhir-types';\nimport type { InterventionData, UserProfileData } from './types';\n\n/**\n * Determine MedicationStatement/Observation status based on end date\n */\nfunction interventionStatus(endDate?: string): 'active' | 'completed' {\n  if (!endDate) return 'active';\n  return new Date(endDate) < new Date() ? 'completed' : 'active';\n}\n\n/**\n * LOINC-like codes for lifestyle observation types\n */\nconst LIFESTYLE_CODES: Record<string, { code: string; display: string }> = {\n  diet: { code: '81259-4', display: 'Diet' },\n  exercise: { code: '73985-4', display: 'Exercise activity' },\n  sleep: { code: '93832-4', display: 'Sleep duration' },\n};\n\n/**\n * Convert medication/supplement intervention to FHIR MedicationStatement\n */\nexport function interventionToFHIRMedicationStatement(\n  intervention: InterventionData,\n  patientId: string,\n): Addressable<FHIRMedicationStatement> {\n  const statement: Addressable<FHIRMedicationStatement> = {\n    category: {\n      coding: [\n        {\n          code: 'patientspecified',\n          display: 'Patient Specified',\n          system: 'http://terminology.hl7.org/CodeSystem/medication-statement-category',\n        },\n      ],\n    },\n    dateAsserted: intervention.startDate,\n    effectivePeriod: {\n      end: intervention.endDate,\n      start: intervention.startDate,\n    },\n    id: `intervention-${intervention.interventionId}`,\n    medicationCodeableConcept: {\n      text: intervention.name,\n    },\n    resourceType: 'MedicationStatement',\n    status: interventionStatus(intervention.endDate),\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n  };\n\n  if (intervention.notes) {\n    statement.note = [{ text: intervention.notes }];\n  }\n\n  return statement;\n}\n\n/**\n * Convert diet/exercise/sleep intervention to FHIR Observation (social-history)\n */\nexport function interventionToFHIRObservation(\n  intervention: InterventionData,\n  patientId: string,\n): Addressable<FHIRObservation> {\n  const lifestyleCode = LIFESTYLE_CODES[intervention.type];\n\n  const observation: Addressable<FHIRObservation> = {\n    category: [\n      {\n        coding: [\n          {\n            code: 'social-history',\n            display: 'Social History',\n            system: 'http://terminology.hl7.org/CodeSystem/observation-category',\n          },\n        ],\n      },\n    ],\n    code: {\n      coding: lifestyleCode\n        ? [\n            {\n              code: lifestyleCode.code,\n              display: lifestyleCode.display,\n              system: 'http://loinc.org',\n            },\n          ]\n        : [],\n      text: intervention.name,\n    },\n    effectivePeriod: {\n      end: intervention.endDate,\n      start: intervention.startDate,\n    },\n    id: `intervention-${intervention.interventionId}`,\n    resourceType: 'Observation',\n    status: 'final',\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n    valueString: intervention.name,\n  };\n\n  if (intervention.notes) {\n    observation.note = [{ text: intervention.notes }];\n  }\n\n  return observation;\n}\n\n/**\n * Convert all interventions to a FHIR Bundle\n */\nexport function interventionsToFHIRBundle(\n  interventions: InterventionData[],\n  userProfile: UserProfileData,\n): FHIRBundle {\n  const patientId = userProfile.userId;\n  const fhirPatient = userProfileToFHIR(userProfile);\n\n  const entries = interventions.map((intervention) => {\n    const isMedication = intervention.type === 'medication' || intervention.type === 'supplement';\n    const resource = isMedication\n      ? interventionToFHIRMedicationStatement(intervention, patientId)\n      : interventionToFHIRObservation(intervention, patientId);\n\n    return { fullUrl: entryFullUrl(resource), resource };\n  });\n\n  return {\n    entry: [{ fullUrl: entryFullUrl(fhirPatient), resource: fhirPatient }, ...entries],\n    resourceType: 'Bundle',\n    type: 'collection',\n  };\n}\n","/**\n * Structured zone data for DEXA body composition and bone density charts.\n *\n * Body fat zones derived from Gallagher et al. Am J Clin Nutr 2000;72:694-701 (PMID: 10966886)\n * and ACSM Guidelines for Exercise Testing, 11th Ed (2021).\n *\n * T-Score zones from WHO criteria (Kanis JA, Osteoporos Int, PMID: 7696835).\n */\n\nexport interface BodyFatZone {\n  ageMax: number;\n  ageMin: number;\n  color: string;\n  fatPctMax: number;\n  fatPctMin: number;\n  label: string;\n  sex: 'F' | 'M';\n}\n\ninterface AgeBracket {\n  ageMax: number;\n  ageMin: number;\n  label: string;\n}\n\nconst AGE_BRACKETS: AgeBracket[] = [\n  { ageMax: 25, ageMin: 18, label: '18-25' },\n  { ageMax: 35, ageMin: 26, label: '26-35' },\n  { ageMax: 45, ageMin: 36, label: '36-45' },\n  { ageMax: 55, ageMin: 46, label: '46-55' },\n  { ageMax: 99, ageMin: 56, label: '56+' },\n];\n\n// Zone boundaries per age bracket for men: [essential, athletic, fitness, average, obese]\n// Each value is the upper bound of the zone\nconst MALE_ZONES: number[][] = [\n  [5, 10, 20, 25, 40],\n  [5, 11, 21, 26, 40],\n  [5, 12, 22, 27, 40],\n  [5, 13, 23, 28, 40],\n  [5, 14, 24, 29, 40],\n];\n\nconst FEMALE_ZONES: number[][] = [\n  [13, 18, 28, 32, 45],\n  [13, 18, 29, 33, 45],\n  [13, 19, 30, 34, 45],\n  [13, 20, 31, 35, 45],\n  [13, 20, 32, 36, 45],\n];\n\ninterface ZoneDefinition {\n  color: string;\n  label: string;\n}\n\nconst ZONE_DEFS: ZoneDefinition[] = [\n  { color: '#3b82f6', label: 'Essencial' },\n  { color: '#06b6d4', label: 'Atlético' },\n  { color: '#22c55e', label: 'Fitness' },\n  { color: '#eab308', label: 'Média' },\n  { color: '#ef4444', label: 'Obeso' },\n];\n\nfunction buildZones(sex: 'F' | 'M', zoneData: number[][]): BodyFatZone[] {\n  const zones: BodyFatZone[] = [];\n  for (let i = 0; i < AGE_BRACKETS.length; i++) {\n    const bracket = AGE_BRACKETS[i]!;\n    const b = zoneData[i]!;\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[0]!.color,\n      fatPctMax: b[0]!,\n      fatPctMin: 0,\n      label: ZONE_DEFS[0]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[1]!.color,\n      fatPctMax: b[1]!,\n      fatPctMin: b[0]!,\n      label: ZONE_DEFS[1]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[2]!.color,\n      fatPctMax: b[2]!,\n      fatPctMin: b[1]!,\n      label: ZONE_DEFS[2]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[3]!.color,\n      fatPctMax: b[3]!,\n      fatPctMin: b[2]!,\n      label: ZONE_DEFS[3]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[4]!.color,\n      fatPctMax: b[4]!,\n      fatPctMin: b[3]!,\n      label: ZONE_DEFS[4]!.label,\n      sex,\n    });\n  }\n  return zones;\n}\n\nexport const BODY_FAT_ZONES: BodyFatZone[] = [\n  ...buildZones('M', MALE_ZONES),\n  ...buildZones('F', FEMALE_ZONES),\n];\n\nexport { AGE_BRACKETS, ZONE_DEFS };\n\nexport interface TScoreZone {\n  color: string;\n  label: string;\n  max: number;\n  min: number;\n}\n\nexport const T_SCORE_ZONES: TScoreZone[] = [\n  { color: '#22c55e', label: 'Normal', max: 4, min: -1.0 },\n  { color: '#eab308', label: 'Osteopenia', max: -1.0, min: -2.5 },\n  { color: '#ef4444', label: 'Osteoporose', max: -2.5, min: -5 },\n];\n","/**\n * Screening Intervals Configuration\n *\n * Defines recommended screening intervals for different biomarker categories\n * based on clinical guidelines and best practices.\n */\n\n/**\n * Screening interval in months\n */\nexport type ScreeningIntervalMonths = 3 | 6 | 12;\n\n/**\n * Biomarker category with its recommended screening interval\n */\nexport interface CategoryScreeningInterval {\n  category: string;\n  intervalMonths: ScreeningIntervalMonths;\n  nameEn: string;\n  namePt: string;\n}\n\n/**\n * Screening interval configuration for each category\n *\n * Categories are grouped by their recommended screening intervals:\n * - 3 months: Body composition and bone density (frequently changing metrics)\n * - 6 months: Metabolic panel and nutrients (moderate change rate)\n * - 12 months: Standard blood panels (stable long-term markers)\n */\nexport const CATEGORY_SCREENING_INTERVALS: CategoryScreeningInterval[] = [\n  // 3-month intervals - Body composition (frequently changing)\n  {\n    category: 'composicao-corporal',\n    intervalMonths: 3,\n    nameEn: 'Body Composition',\n    namePt: 'Composição Corporal',\n  },\n  {\n    category: 'densidade-ossea',\n    intervalMonths: 3,\n    nameEn: 'Bone Density',\n    namePt: 'Densidade Óssea',\n  },\n\n  // 6-month intervals - Metabolic and nutrients\n  {\n    category: 'metabolico',\n    intervalMonths: 6,\n    nameEn: 'Metabolic Panel',\n    namePt: 'Painel Metabólico',\n  },\n  {\n    category: 'nutrientes',\n    intervalMonths: 6,\n    nameEn: 'Nutrients',\n    namePt: 'Nutrientes',\n  },\n  {\n    category: 'pancreas',\n    intervalMonths: 6,\n    nameEn: 'Pancreas',\n    namePt: 'Pâncreas',\n  },\n\n  // 12-month intervals - Standard blood panels\n  {\n    category: 'coracao',\n    intervalMonths: 12,\n    nameEn: 'Heart Health',\n    namePt: 'Saúde Cardiovascular',\n  },\n  {\n    category: 'tireoide',\n    intervalMonths: 12,\n    nameEn: 'Thyroid',\n    namePt: 'Tireoide',\n  },\n  {\n    category: 'sangue',\n    intervalMonths: 12,\n    nameEn: 'Blood Count',\n    namePt: 'Hemograma',\n  },\n  {\n    category: 'figado',\n    intervalMonths: 12,\n    nameEn: 'Liver Function',\n    namePt: 'Função Hepática',\n  },\n  {\n    category: 'rins',\n    intervalMonths: 12,\n    nameEn: 'Kidney Function',\n    namePt: 'Função Renal',\n  },\n  {\n    category: 'saude-feminina',\n    intervalMonths: 12,\n    nameEn: \"Women's Health\",\n    namePt: 'Saúde Feminina',\n  },\n  {\n    category: 'saude-masculina',\n    intervalMonths: 12,\n    nameEn: \"Men's Health\",\n    namePt: 'Saúde Masculina',\n  },\n  {\n    category: 'eletrolitos',\n    intervalMonths: 12,\n    nameEn: 'Electrolytes',\n    namePt: 'Eletrólitos',\n  },\n  {\n    category: 'estresse-envelhecimento',\n    intervalMonths: 12,\n    nameEn: 'Stress & Aging',\n    namePt: 'Estresse e Envelhecimento',\n  },\n  {\n    category: 'autoimunidade',\n    intervalMonths: 12,\n    nameEn: 'Autoimmunity',\n    namePt: 'Autoimunidade',\n  },\n  {\n    category: 'regulacao-imunologica',\n    intervalMonths: 12,\n    nameEn: 'Immune Regulation',\n    namePt: 'Regulação Imunológica',\n  },\n  {\n    category: 'toxinas-ambientais',\n    intervalMonths: 12,\n    nameEn: 'Environmental Toxins',\n    namePt: 'Toxinas Ambientais',\n  },\n  {\n    category: 'urina',\n    intervalMonths: 12,\n    nameEn: 'Urinalysis',\n    namePt: 'Urina',\n  },\n];\n\n/**\n * Get screening interval for a category\n */\nexport const getScreeningInterval = (category: string): CategoryScreeningInterval | undefined => {\n  return CATEGORY_SCREENING_INTERVALS.find((c) => c.category === category);\n};\n\n/**\n * Get all categories with a specific interval\n */\nexport const getCategoriesByInterval = (\n  intervalMonths: ScreeningIntervalMonths,\n): CategoryScreeningInterval[] => {\n  return CATEGORY_SCREENING_INTERVALS.filter((c) => c.intervalMonths === intervalMonths);\n};\n\n/**\n * Calculate next screening date based on last test date and category\n */\nexport const calculateNextScreeningDate = (lastTestDate: Date, category: string): Date | null => {\n  const interval = getScreeningInterval(category);\n  if (!interval) return null;\n\n  const nextDate = new Date(lastTestDate);\n  nextDate.setMonth(nextDate.getMonth() + interval.intervalMonths);\n  return nextDate;\n};\n\n/**\n * Check if a category is due for screening\n */\nexport const isScreeningDue = (\n  lastTestDate: Date,\n  category: string,\n  referenceDate: Date = new Date(),\n): boolean => {\n  const nextDate = calculateNextScreeningDate(lastTestDate, category);\n  if (!nextDate) return false;\n  return referenceDate >= nextDate;\n};\n\n/**\n * Get categories that are due for screening based on last test dates\n */\nexport const getDueCategories = (\n  lastTestDates: Record<string, Date>,\n  referenceDate: Date = new Date(),\n): CategoryScreeningInterval[] => {\n  return CATEGORY_SCREENING_INTERVALS.filter((interval) => {\n    const lastDate = lastTestDates[interval.category];\n    if (!lastDate) return true; // Never tested = due\n    return isScreeningDue(lastDate, interval.category, referenceDate);\n  });\n};\n\n/**\n * Get days until next screening for a category\n */\nexport const getDaysUntilScreening = (\n  lastTestDate: Date,\n  category: string,\n  referenceDate: Date = new Date(),\n): number | null => {\n  const nextDate = calculateNextScreeningDate(lastTestDate, category);\n  if (!nextDate) return null;\n\n  const diffTime = nextDate.getTime() - referenceDate.getTime();\n  return Math.ceil(diffTime / (1000 * 60 * 60 * 24));\n};\n","/**\n * Portuguese pluralization utility using native Intl.PluralRules\n * Provides automatic pluralization for common words used in the app\n */\n\nconst pluralRules = new Intl.PluralRules('pt-BR');\n\n/**\n * Dictionary of Portuguese words with their plural forms\n * Key is the singular form, value is the plural form\n */\nconst dictionary: Record<string, string> = {\n  // Common nouns\n  arquivo: 'arquivos',\n  biomarcador: 'biomarcadores',\n  // Past participles (masculine)\n  cadastrado: 'cadastrados',\n  // Past participles (feminine)\n  concluída: 'concluídas',\n  confirmado: 'confirmados',\n  convertido: 'convertidos',\n  convidado: 'convidados',\n  convite: 'convites',\n  disponível: 'disponíveis',\n  documento: 'documentos',\n  enviado: 'enviados',\n  exame: 'exames',\n  excluída: 'excluídas',\n\n  excluído: 'excluídos',\n  // Verbs (3rd person)\n  falhou: 'falharam',\n  falta: 'faltam',\n  ignorado: 'ignorados',\n  item: 'itens',\n  outro: 'outros',\n  página: 'páginas',\n  pendente: 'pendentes',\n  registro: 'registros',\n  removido: 'removidos',\n\n  resultado: 'resultados',\n  revisão: 'revisões',\n\n  revogado: 'revogados',\n  usuário: 'usuários',\n};\n\n/**\n * Get the plural form of a word from the dictionary\n * Falls back to adding 's' if word is not in dictionary\n */\nconst getPluralForm = (singular: string): string => {\n  return dictionary[singular] ?? `${singular}s`;\n};\n\n/**\n * Returns the correct singular or plural form based on count\n * Uses Intl.PluralRules for proper locale-aware pluralization\n *\n * @example\n * plural(1, 'usuário') // 'usuário'\n * plural(3, 'usuário') // 'usuários'\n * plural(0, 'registro') // 'registros'\n */\nexport const plural = (count: number, word: string): string => {\n  const rule = pluralRules.select(count);\n  return rule === 'one' ? word : getPluralForm(word);\n};\n\n/**\n * Returns count with the correct singular or plural form\n *\n * @example\n * pluralCount(1, 'usuário') // '1 usuário'\n * pluralCount(3, 'usuário') // '3 usuários'\n */\nexport const pluralCount = (count: number, word: string): string => {\n  return `${count} ${plural(count, word)}`;\n};\n\n/**\n * Returns the correct form for compound phrases (noun + adjective)\n * Both words are pluralized together\n *\n * @example\n * pluralPhrase(1, 'usuário', 'cadastrado') // 'usuário cadastrado'\n * pluralPhrase(3, 'usuário', 'cadastrado') // 'usuários cadastrados'\n * pluralPhrase(2, 'revisão', 'excluída') // 'revisões excluídas'\n */\nexport const pluralPhrase = (count: number, noun: string, adjective: string): string => {\n  const rule = pluralRules.select(count);\n  if (rule === 'one') {\n    return `${noun} ${adjective}`;\n  }\n  return `${getPluralForm(noun)} ${getPluralForm(adjective)}`;\n};\n\n/**\n * Returns count with the correct compound phrase form\n *\n * @example\n * pluralPhraseCount(1, 'usuário', 'cadastrado') // '1 usuário cadastrado'\n * pluralPhraseCount(3, 'convite', 'enviado') // '3 convites enviados'\n */\nexport const pluralPhraseCount = (count: number, noun: string, adjective: string): string => {\n  return `${count} ${pluralPhrase(count, noun, adjective)}`;\n};\n","/**\n * Helpers para identificadores brasileiros — CPF e CNS\n *\n * Validação, formatação e conversão para FHIR Identifier.\n * Algoritmos de validação baseados nas especificações oficiais:\n * - CPF: Receita Federal (mod-11, dois dígitos verificadores)\n * - CNS: Ministério da Saúde (mod-11 para definitivos, soma ponderada para provisórios)\n */\n\nimport type { FHIRIdentifier } from './fhir-types';\n\nconst CPF_SYSTEM = 'http://rnds.saude.gov.br/fhir/r4/NamingSystem/cpf';\nconst CNS_SYSTEM = 'http://rnds.saude.gov.br/fhir/r4/NamingSystem/cns';\n\n/**\n * Remove caracteres não-numéricos de uma string.\n */\nfunction digitsOnly(value: string): string {\n  return value.replace(/\\D/g, '');\n}\n\n/**\n * Valida um CPF brasileiro usando algoritmo mod-11.\n *\n * @param cpf — CPF com ou sem formatação (ex: \"123.456.789-09\" ou \"12345678909\")\n * @returns true se o CPF é estruturalmente válido\n */\nexport function validateCPF(cpf: string): boolean {\n  const digits = digitsOnly(cpf);\n\n  if (digits.length !== 11) return false;\n\n  // Rejeitar sequências de dígitos iguais (ex: 111.111.111-11)\n  if (/^(\\d)\\1{10}$/.test(digits)) return false;\n\n  // Primeiro dígito verificador\n  let sum = 0;\n  for (let i = 0; i < 9; i++) {\n    sum += Number(digits[i]) * (10 - i);\n  }\n  let remainder = (sum * 10) % 11;\n  if (remainder === 10) remainder = 0;\n  if (remainder !== Number(digits[9])) return false;\n\n  // Segundo dígito verificador\n  sum = 0;\n  for (let i = 0; i < 10; i++) {\n    sum += Number(digits[i]) * (11 - i);\n  }\n  remainder = (sum * 10) % 11;\n  if (remainder === 10) remainder = 0;\n  if (remainder !== Number(digits[10])) return false;\n\n  return true;\n}\n\n/**\n * Valida um CNS (Cartão Nacional de Saúde) brasileiro.\n *\n * CNS definitivos começam com 1 ou 2 (mod-11).\n * CNS provisórios começam com 7, 8 ou 9 (soma ponderada mod-11 = 0).\n *\n * @param cns — CNS com 15 dígitos\n * @returns true se o CNS é estruturalmente válido\n */\nexport function validateCNS(cns: string): boolean {\n  const digits = digitsOnly(cns);\n\n  if (digits.length !== 15) return false;\n\n  const firstDigit = digits[0]!;\n\n  // CNS deve começar com 1, 2 (definitivo) ou 7, 8, 9 (provisório)\n  if (!['1', '2', '7', '8', '9'].includes(firstDigit)) return false;\n\n  // Ambos os tipos usam soma ponderada mod-11 = 0\n  let sum = 0;\n  for (let i = 0; i < 15; i++) {\n    sum += Number(digits[i]) * (15 - i);\n  }\n  return sum % 11 === 0;\n}\n\n/**\n * Formata um CPF como XXX.XXX.XXX-XX.\n *\n * @param cpf — CPF com 11 dígitos (com ou sem formatação)\n * @returns CPF formatado ou a string original se inválido\n */\nexport function formatCPF(cpf: string): string {\n  const digits = digitsOnly(cpf);\n  if (digits.length !== 11) return cpf;\n  return `${digits.slice(0, 3)}.${digits.slice(3, 6)}.${digits.slice(6, 9)}-${digits.slice(9)}`;\n}\n\n/**\n * Formata um CNS como XXX XXXX XXXX XXXX.\n *\n * @param cns — CNS com 15 dígitos\n * @returns CNS formatado ou a string original se inválido\n */\nexport function formatCNS(cns: string): string {\n  const digits = digitsOnly(cns);\n  if (digits.length !== 15) return cns;\n  return `${digits.slice(0, 3)} ${digits.slice(3, 7)} ${digits.slice(7, 11)} ${digits.slice(11)}`;\n}\n\n/**\n * Converte um CPF para um FHIR Identifier.\n *\n * @param cpf — CPF com 11 dígitos (com ou sem formatação)\n * @returns FHIR Identifier com sistema RNDS para CPF\n * @throws Error se o CPF for inválido\n */\nexport function cpfToFHIRIdentifier(cpf: string): FHIRIdentifier {\n  if (!validateCPF(cpf)) {\n    throw new Error('CPF inválido');\n  }\n  return {\n    system: CPF_SYSTEM,\n    use: 'official',\n    value: digitsOnly(cpf),\n  };\n}\n\n/**\n * Converte um CNS para um FHIR Identifier.\n *\n * @param cns — CNS com 15 dígitos\n * @returns FHIR Identifier com sistema RNDS para CNS\n * @throws Error se o CNS for inválido\n */\nexport function cnsToFHIRIdentifier(cns: string): FHIRIdentifier {\n  if (!validateCNS(cns)) {\n    throw new Error('CNS inválido');\n  }\n  return {\n    system: CNS_SYSTEM,\n    use: 'official',\n    value: digitsOnly(cns),\n  };\n}\n","/**\n * URLs das extensões do IG do fhir-brasil.\n *\n * Quem emite a extensão e quem a lê precisam concordar literalmente na URL: um\n * consumidor procura a extensão pelo `url`, e uma grafia divergente faz o dado\n * sumir sem erro. O teste confere cada uma contra o `Id:` do FSH em\n * `ig/input/fsh/extensions/`, então extensão nova no IG sem constante aqui, ou\n * o inverso, reprova.\n */\n\n/** Canonical do IG, como está no `sushi-config.yaml`. */\nexport const IG_CANONICAL = 'https://fhir-brasil.dev.br/ig';\n\nconst structureDefinition = (id: string): string => `${IG_CANONICAL}/StructureDefinition/${id}`;\n\n/**\n * Extensões do IG, pela URL.\n *\n * As que têm partes (`extractionSource`, `extractionConfidence`, `asPrinted`)\n * levam as partes em `extension[]` aninhado, cada uma com `url` relativo: o\n * nome da parte, como `page` ou `reading`. Ver o FSH de cada uma.\n */\nexport const FHIR_BRASIL_EXTENSIONS = {\n  /** `Observation`: valor e faixa como impressos, quando a Observation traz outros. */\n  asPrinted: structureDefinition('as-printed'),\n  /** `Observation`: extraída de PDF via OCR. */\n  derivedFromOCR: structureDefinition('derived-from-ocr'),\n  /** `Observation`: confiança na leitura e na interpretação, de 0 a 1. */\n  extractionConfidence: structureDefinition('extraction-confidence'),\n  /** `Observation`: páginas, trecho citado e caixa do trecho no documento. */\n  extractionSource: structureDefinition('extraction-source'),\n  /** `DiagnosticReport`: lido da tabela de histórico de outro laudo. */\n  reprintedIn: structureDefinition('reprinted-in'),\n  /** `Observation`: lido do documento, mas substituído por outro valor do mesmo laudo. */\n  superseded: structureDefinition('superseded'),\n  /** `Observation`: unidade impressa ao lado de um resultado em texto. */\n  textValueUnit: structureDefinition('text-value-unit'),\n} as const;\n","/**\n * Código do tipo de amostra a partir do material impresso no laudo.\n *\n * O perfil `BRAmostraBiologica-1.0` da RNDS vincula `Specimen.type` ao ValueSet\n * `BRTipoAmostra-1.0` com força `required`, exige `type.coding` (1..1) e proíbe\n * `type.text` (0..0). Um `Specimen` só com o texto do laudo não passa, e é o que\n * a extração produzia.\n *\n * O ValueSet tem 63 códigos, e quase todos são de vigilância respiratória vindos\n * do GAL: swab nasofaríngeo, lavado brônquico, fragmento de órgão. Para laudo de\n * rotina sobram seis, e esses seis cobrem o que um painel de sangue e urina\n * imprime.\n *\n * Não há código para fezes no ValueSet. Isso não afeta a extração, cujo catálogo\n * não tem nenhum biomarcador de origem fecal: um parasitológico não vira\n * `Observation`, então não chega a pedir `Specimen`.\n *\n * @see https://rnds-fhir.saude.gov.br/StructureDefinition-BRAmostraBiologica-1.0.html\n * @see https://rnds-fhir.saude.gov.br/ValueSet-BRTipoAmostra-1.0.html\n */\nimport type { FHIRCoding } from './fhir-types';\n\n/** ValueSet ao qual `Specimen.type` está vinculado no `BRAmostraBiologica`. */\nexport const BR_TIPO_AMOSTRA_VALUESET = 'https://rnds-fhir.saude.gov.br/ValueSet/BRTipoAmostra-1.0';\n\n/**\n * CodeSystem dos códigos que este módulo emite.\n *\n * O ValueSet também inclui o `BRTipoAmostraGAL`, que traz \"Sangue\" e \"Sangue com\n * EDTA\" soltos. Ficaram de fora porque a URL canônica daquele CodeSystem não foi\n * confirmada na fonte, e código de terminologia não se deduz de slug. Material\n * assim cai no caminho de não mapeado até alguém abrir o IG e confirmar.\n */\nexport const HL7_SPECIMEN_TYPE_SYSTEM = 'http://terminology.hl7.org/CodeSystem/v2-0487';\n\n/**\n * Os `display` são cópia literal do ValueSet, com a caixa dele.\n *\n * A chave é o texto já normalizado, e por enquanto é só o próprio display. Não\n * há sinônimo inventado aqui: a extração copia o material verbatim do laudo, e a\n * lista de variações que os laboratórios de fato imprimem ainda não foi medida\n * (a captura de material entrou em produção em 05/09/2026). Variação real\n * observada entra depois, com o laudo que a produziu.\n */\nconst CODINGS: ReadonlyArray<{ code: string; display: string }> = [\n  { code: 'SER', display: 'Soro' },\n  { code: 'PLAS', display: 'Plasma' },\n  { code: 'WB', display: 'Sangue Total' },\n  { code: 'UR', display: 'Urina' },\n  { code: 'CSF', display: 'Líquor' },\n  { code: 'SAL', display: 'Saliva' },\n];\n\n/**\n * Caixa, acento e espaço sobrando não distinguem material.\n *\n * Só isso. Não separa `camelCase` nem troca barra por espaço, ao contrário do\n * normalizador de nomes de biomarcador: \"Soro/Plasma\" impresso numa linha só é\n * ambíguo de verdade, e escolher um dos dois seria inferência. Sem casar, ele\n * segue o caminho do não mapeado.\n *\n * Os caracteres invisíveis saem antes, e a divisão entre as duas regras é a do\n * próprio Unicode: `\\p{Cf}` são os de formatação, que não ocupam espaço e por\n * isso são apagados, e `\\s` são os de espaço, que são colapsados. A camada de\n * texto de PDF emite os dois tipos, e um U+200B no meio de \"Soro\" derruba o\n * casamento sem deixar rastro na tela.\n *\n * Vale a categoria em vez da lista porque a lista nunca fecha. Enumerando, o\n * hífen opcional (U+00AD) tinha ficado de fora, e ele aparece justamente onde\n * um nome composto como \"Sangue Total\" quebra de linha.\n */\nconst INVISIBLE = /\\p{Cf}/gu;\n\nconst normalize = (text: string): string =>\n  text\n    .replace(INVISIBLE, '')\n    .normalize('NFD')\n    .replace(/[\\u0300-\\u036f]/g, '')\n    .toLowerCase()\n    .replace(/\\s+/g, ' ')\n    .trim();\n\nconst BY_NORMALIZED_TEXT = new Map(\n  CODINGS.map(({ code, display }) => [\n    normalize(display),\n    { code, display, system: HL7_SPECIMEN_TYPE_SYSTEM } satisfies FHIRCoding,\n  ]),\n);\n\n/**\n * Coding do ValueSet para o material impresso, ou `undefined` sem casar.\n *\n * `undefined` é resposta legítima e não erro: o laudo pode trazer um material\n * fora do ValueSet, ou uma grafia que ninguém viu ainda. Quem chama decide o que\n * fazer, e a decisão que não existe é preencher com um código aproximado.\n */\nexport const specimenTypeCoding = (text: string): FHIRCoding | undefined =>\n  BY_NORMALIZED_TEXT.get(normalize(text));\n"]}
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Este módulo agrupa essas\n * sub-categorias em 10 buckets clínicos amplos para apresentação no\n * site, na API pública e em material de divulgação.\n *\n * As sub-categorias permanecem como fonte da verdade nos dados; este\n * agrupamento é uma camada derivada.\n */\n\nexport type CategoryGroup =\n  | 'cardiovascular'\n  | 'metabolico-endocrino'\n  | 'renal-eletrolitico'\n  | 'hepatico-biliar'\n  | 'hematologico'\n  | 'imunologico'\n  | 'oncologico'\n  | 'nutricional-ambiental'\n  | 'saude-reprodutiva'\n  | 'composicao-envelhecimento';\n\nexport interface CategoryGroupInfo {\n  /** Rótulo em inglês */\n  en: string;\n  /** Rótulo em português */\n  pt: string;\n  /** Slug (kebab-case, sem acento) */\n  slug: CategoryGroup;\n  /** Sub-categorias da fonte agrupadas neste bucket */\n  subcategories: readonly string[];\n}\n\nexport const CATEGORY_GROUPS: Record<CategoryGroup, CategoryGroupInfo> = {\n  cardiovascular: {\n    en: 'Cardiovascular',\n    pt: 'Cardiovascular',\n    slug: 'cardiovascular',\n    subcategories: ['coracao'],\n  },\n  'composicao-envelhecimento': {\n    en: 'Body Composition & Aging',\n    pt: 'Composição Corporal e Envelhecimento',\n    slug: 'composicao-envelhecimento',\n    subcategories: ['composicao-corporal', 'densidade-ossea', 'estresse-envelhecimento'],\n  },\n  hematologico: {\n    en: 'Hematology',\n    pt: 'Hematológico',\n    slug: 'hematologico',\n    subcategories: ['sangue'],\n  },\n  'hepatico-biliar': {\n    en: 'Hepatic & Biliary',\n    pt: 'Hepático e Biliar',\n    slug: 'hepatico-biliar',\n    subcategories: ['figado'],\n  },\n  imunologico: {\n    en: 'Immunology',\n    pt: 'Imunológico',\n    slug: 'imunologico',\n    subcategories: ['autoimunidade', 'regulacao-imunologica'],\n  },\n  'metabolico-endocrino': {\n    en: 'Metabolic & Endocrine',\n    pt: 'Metabólico e Endócrino',\n    slug: 'metabolico-endocrino',\n    subcategories: ['metabolico', 'pancreas', 'hormonios', 'tireoide'],\n  },\n  'nutricional-ambiental': {\n    en: 'Nutrition & Environmental Exposure',\n    pt: 'Nutricional e Exposição Ambiental',\n    slug: 'nutricional-ambiental',\n    subcategories: ['nutrientes', 'toxinas-ambientais'],\n  },\n  oncologico: {\n    en: 'Oncology',\n    pt: 'Oncológico',\n    slug: 'oncologico',\n    subcategories: ['marcadores-tumorais'],\n  },\n  'renal-eletrolitico': {\n    en: 'Renal & Electrolytes',\n    pt: 'Renal e Eletrolítico',\n    slug: 'renal-eletrolitico',\n    subcategories: ['rins', 'urina', 'eletrolitos'],\n  },\n  'saude-reprodutiva': {\n    en: 'Reproductive Health',\n    pt: 'Saúde Reprodutiva',\n    slug: 'saude-reprodutiva',\n    subcategories: ['saude-feminina', 'saude-masculina'],\n  },\n};\n\nconst SUBCATEGORY_TO_GROUP = new Map<string, CategoryGroup>();\nfor (const group of Object.values(CATEGORY_GROUPS)) {\n  for (const sub of group.subcategories) {\n    SUBCATEGORY_TO_GROUP.set(sub, group.slug);\n  }\n}\n\n/**\n * Resolve a sub-categoria (granular) para o grupo de alto nível (10 buckets).\n */\nexport function getCategoryGroup(subcategory: string): CategoryGroup | undefined {\n  return SUBCATEGORY_TO_GROUP.get(subcategory);\n}\n\n/**\n * Lista todas as sub-categorias mapeadas em algum grupo.\n */\nexport function listMappedSubcategories(): readonly string[] {\n  return [...SUBCATEGORY_TO_GROUP.keys()];\n}\n","/**\n * FHIR Intervention Converter\n *\n * Converts interventions (medication, supplement, diet, exercise, sleep)\n * to FHIR R4 MedicationStatement and Observation resources.\n */\n\nimport { type Addressable, entryFullUrl } from './bundle-urls';\nimport { userProfileToFHIR } from './converter';\nimport type { FHIRBundle, FHIRMedicationStatement, FHIRObservation } from './fhir-types';\nimport type { InterventionData, UserProfileData } from './types';\n\n/**\n * Determine MedicationStatement/Observation status based on end date\n */\nfunction interventionStatus(endDate?: string): 'active' | 'completed' {\n  if (!endDate) return 'active';\n  return new Date(endDate) < new Date() ? 'completed' : 'active';\n}\n\n/**\n * LOINC-like codes for lifestyle observation types\n */\nconst LIFESTYLE_CODES: Record<string, { code: string; display: string }> = {\n  diet: { code: '81259-4', display: 'Diet' },\n  exercise: { code: '73985-4', display: 'Exercise activity' },\n  sleep: { code: '93832-4', display: 'Sleep duration' },\n};\n\n/**\n * Convert medication/supplement intervention to FHIR MedicationStatement\n */\nexport function interventionToFHIRMedicationStatement(\n  intervention: InterventionData,\n  patientId: string,\n): Addressable<FHIRMedicationStatement> {\n  const statement: Addressable<FHIRMedicationStatement> = {\n    category: {\n      coding: [\n        {\n          code: 'patientspecified',\n          display: 'Patient Specified',\n          system: 'http://terminology.hl7.org/CodeSystem/medication-statement-category',\n        },\n      ],\n    },\n    dateAsserted: intervention.startDate,\n    effectivePeriod: {\n      end: intervention.endDate,\n      start: intervention.startDate,\n    },\n    id: `intervention-${intervention.interventionId}`,\n    medicationCodeableConcept: {\n      text: intervention.name,\n    },\n    resourceType: 'MedicationStatement',\n    status: interventionStatus(intervention.endDate),\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n  };\n\n  if (intervention.notes) {\n    statement.note = [{ text: intervention.notes }];\n  }\n\n  return statement;\n}\n\n/**\n * Convert diet/exercise/sleep intervention to FHIR Observation (social-history)\n */\nexport function interventionToFHIRObservation(\n  intervention: InterventionData,\n  patientId: string,\n): Addressable<FHIRObservation> {\n  const lifestyleCode = LIFESTYLE_CODES[intervention.type];\n\n  const observation: Addressable<FHIRObservation> = {\n    category: [\n      {\n        coding: [\n          {\n            code: 'social-history',\n            display: 'Social History',\n            system: 'http://terminology.hl7.org/CodeSystem/observation-category',\n          },\n        ],\n      },\n    ],\n    code: {\n      coding: lifestyleCode\n        ? [\n            {\n              code: lifestyleCode.code,\n              display: lifestyleCode.display,\n              system: 'http://loinc.org',\n            },\n          ]\n        : [],\n      text: intervention.name,\n    },\n    effectivePeriod: {\n      end: intervention.endDate,\n      start: intervention.startDate,\n    },\n    id: `intervention-${intervention.interventionId}`,\n    resourceType: 'Observation',\n    status: 'final',\n    subject: {\n      reference: `Patient/${patientId}`,\n    },\n    valueString: intervention.name,\n  };\n\n  if (intervention.notes) {\n    observation.note = [{ text: intervention.notes }];\n  }\n\n  return observation;\n}\n\n/**\n * Convert all interventions to a FHIR Bundle\n */\nexport function interventionsToFHIRBundle(\n  interventions: InterventionData[],\n  userProfile: UserProfileData,\n): FHIRBundle {\n  const patientId = userProfile.userId;\n  const fhirPatient = userProfileToFHIR(userProfile);\n\n  const entries = interventions.map((intervention) => {\n    const isMedication = intervention.type === 'medication' || intervention.type === 'supplement';\n    const resource = isMedication\n      ? interventionToFHIRMedicationStatement(intervention, patientId)\n      : interventionToFHIRObservation(intervention, patientId);\n\n    return { fullUrl: entryFullUrl(resource), resource };\n  });\n\n  return {\n    entry: [{ fullUrl: entryFullUrl(fhirPatient), resource: fhirPatient }, ...entries],\n    resourceType: 'Bundle',\n    type: 'collection',\n  };\n}\n","/**\n * Structured zone data for DEXA body composition and bone density charts.\n *\n * Body fat zones derived from Gallagher et al. Am J Clin Nutr 2000;72:694-701 (PMID: 10966886)\n * and ACSM Guidelines for Exercise Testing, 11th Ed (2021).\n *\n * T-Score zones from WHO criteria (Kanis JA, Osteoporos Int, PMID: 7696835).\n */\n\nexport interface BodyFatZone {\n  ageMax: number;\n  ageMin: number;\n  color: string;\n  fatPctMax: number;\n  fatPctMin: number;\n  label: string;\n  sex: 'F' | 'M';\n}\n\ninterface AgeBracket {\n  ageMax: number;\n  ageMin: number;\n  label: string;\n}\n\nconst AGE_BRACKETS: AgeBracket[] = [\n  { ageMax: 25, ageMin: 18, label: '18-25' },\n  { ageMax: 35, ageMin: 26, label: '26-35' },\n  { ageMax: 45, ageMin: 36, label: '36-45' },\n  { ageMax: 55, ageMin: 46, label: '46-55' },\n  { ageMax: 99, ageMin: 56, label: '56+' },\n];\n\n// Zone boundaries per age bracket for men: [essential, athletic, fitness, average, obese]\n// Each value is the upper bound of the zone\nconst MALE_ZONES: number[][] = [\n  [5, 10, 20, 25, 40],\n  [5, 11, 21, 26, 40],\n  [5, 12, 22, 27, 40],\n  [5, 13, 23, 28, 40],\n  [5, 14, 24, 29, 40],\n];\n\nconst FEMALE_ZONES: number[][] = [\n  [13, 18, 28, 32, 45],\n  [13, 18, 29, 33, 45],\n  [13, 19, 30, 34, 45],\n  [13, 20, 31, 35, 45],\n  [13, 20, 32, 36, 45],\n];\n\ninterface ZoneDefinition {\n  color: string;\n  label: string;\n}\n\nconst ZONE_DEFS: ZoneDefinition[] = [\n  { color: '#3b82f6', label: 'Essencial' },\n  { color: '#06b6d4', label: 'Atlético' },\n  { color: '#22c55e', label: 'Fitness' },\n  { color: '#eab308', label: 'Média' },\n  { color: '#ef4444', label: 'Obeso' },\n];\n\nfunction buildZones(sex: 'F' | 'M', zoneData: number[][]): BodyFatZone[] {\n  const zones: BodyFatZone[] = [];\n  for (let i = 0; i < AGE_BRACKETS.length; i++) {\n    const bracket = AGE_BRACKETS[i]!;\n    const b = zoneData[i]!;\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[0]!.color,\n      fatPctMax: b[0]!,\n      fatPctMin: 0,\n      label: ZONE_DEFS[0]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[1]!.color,\n      fatPctMax: b[1]!,\n      fatPctMin: b[0]!,\n      label: ZONE_DEFS[1]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[2]!.color,\n      fatPctMax: b[2]!,\n      fatPctMin: b[1]!,\n      label: ZONE_DEFS[2]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[3]!.color,\n      fatPctMax: b[3]!,\n      fatPctMin: b[2]!,\n      label: ZONE_DEFS[3]!.label,\n      sex,\n    });\n    zones.push({\n      ...bracket,\n      color: ZONE_DEFS[4]!.color,\n      fatPctMax: b[4]!,\n      fatPctMin: b[3]!,\n      label: ZONE_DEFS[4]!.label,\n      sex,\n    });\n  }\n  return zones;\n}\n\nexport const BODY_FAT_ZONES: BodyFatZone[] = [\n  ...buildZones('M', MALE_ZONES),\n  ...buildZones('F', FEMALE_ZONES),\n];\n\nexport { AGE_BRACKETS, ZONE_DEFS };\n\nexport interface TScoreZone {\n  color: string;\n  label: string;\n  max: number;\n  min: number;\n}\n\nexport const T_SCORE_ZONES: TScoreZone[] = [\n  { color: '#22c55e', label: 'Normal', max: 4, min: -1.0 },\n  { color: '#eab308', label: 'Osteopenia', max: -1.0, min: -2.5 },\n  { color: '#ef4444', label: 'Osteoporose', max: -2.5, min: -5 },\n];\n","/**\n * Screening Intervals Configuration\n *\n * Defines recommended screening intervals for different biomarker categories\n * based on clinical guidelines and best practices.\n */\n\n/**\n * Screening interval in months\n */\nexport type ScreeningIntervalMonths = 3 | 6 | 12;\n\n/**\n * Biomarker category with its recommended screening interval\n */\nexport interface CategoryScreeningInterval {\n  category: string;\n  intervalMonths: ScreeningIntervalMonths;\n  nameEn: string;\n  namePt: string;\n}\n\n/**\n * Screening interval configuration for each category\n *\n * Categories are grouped by their recommended screening intervals:\n * - 3 months: Body composition and bone density (frequently changing metrics)\n * - 6 months: Metabolic panel and nutrients (moderate change rate)\n * - 12 months: Standard blood panels (stable long-term markers)\n */\nexport const CATEGORY_SCREENING_INTERVALS: CategoryScreeningInterval[] = [\n  // 3-month intervals - Body composition (frequently changing)\n  {\n    category: 'composicao-corporal',\n    intervalMonths: 3,\n    nameEn: 'Body Composition',\n    namePt: 'Composição Corporal',\n  },\n  {\n    category: 'densidade-ossea',\n    intervalMonths: 3,\n    nameEn: 'Bone Density',\n    namePt: 'Densidade Óssea',\n  },\n\n  // 6-month intervals - Metabolic and nutrients\n  {\n    category: 'metabolico',\n    intervalMonths: 6,\n    nameEn: 'Metabolic Panel',\n    namePt: 'Painel Metabólico',\n  },\n  {\n    category: 'nutrientes',\n    intervalMonths: 6,\n    nameEn: 'Nutrients',\n    namePt: 'Nutrientes',\n  },\n  {\n    category: 'pancreas',\n    intervalMonths: 6,\n    nameEn: 'Pancreas',\n    namePt: 'Pâncreas',\n  },\n\n  // 12-month intervals - Standard blood panels\n  {\n    category: 'coracao',\n    intervalMonths: 12,\n    nameEn: 'Heart Health',\n    namePt: 'Saúde Cardiovascular',\n  },\n  {\n    category: 'tireoide',\n    intervalMonths: 12,\n    nameEn: 'Thyroid',\n    namePt: 'Tireoide',\n  },\n  {\n    category: 'sangue',\n    intervalMonths: 12,\n    nameEn: 'Blood Count',\n    namePt: 'Hemograma',\n  },\n  {\n    category: 'figado',\n    intervalMonths: 12,\n    nameEn: 'Liver Function',\n    namePt: 'Função Hepática',\n  },\n  {\n    category: 'rins',\n    intervalMonths: 12,\n    nameEn: 'Kidney Function',\n    namePt: 'Função Renal',\n  },\n  {\n    category: 'saude-feminina',\n    intervalMonths: 12,\n    nameEn: \"Women's Health\",\n    namePt: 'Saúde Feminina',\n  },\n  {\n    category: 'saude-masculina',\n    intervalMonths: 12,\n    nameEn: \"Men's Health\",\n    namePt: 'Saúde Masculina',\n  },\n  {\n    category: 'eletrolitos',\n    intervalMonths: 12,\n    nameEn: 'Electrolytes',\n    namePt: 'Eletrólitos',\n  },\n  {\n    category: 'estresse-envelhecimento',\n    intervalMonths: 12,\n    nameEn: 'Stress & Aging',\n    namePt: 'Estresse e Envelhecimento',\n  },\n  {\n    category: 'autoimunidade',\n    intervalMonths: 12,\n    nameEn: 'Autoimmunity',\n    namePt: 'Autoimunidade',\n  },\n  {\n    category: 'regulacao-imunologica',\n    intervalMonths: 12,\n    nameEn: 'Immune Regulation',\n    namePt: 'Regulação Imunológica',\n  },\n  {\n    category: 'toxinas-ambientais',\n    intervalMonths: 12,\n    nameEn: 'Environmental Toxins',\n    namePt: 'Toxinas Ambientais',\n  },\n  {\n    category: 'urina',\n    intervalMonths: 12,\n    nameEn: 'Urinalysis',\n    namePt: 'Urina',\n  },\n];\n\n/**\n * Get screening interval for a category\n */\nexport const getScreeningInterval = (category: string): CategoryScreeningInterval | undefined => {\n  return CATEGORY_SCREENING_INTERVALS.find((c) => c.category === category);\n};\n\n/**\n * Get all categories with a specific interval\n */\nexport const getCategoriesByInterval = (\n  intervalMonths: ScreeningIntervalMonths,\n): CategoryScreeningInterval[] => {\n  return CATEGORY_SCREENING_INTERVALS.filter((c) => c.intervalMonths === intervalMonths);\n};\n\n/**\n * Calculate next screening date based on last test date and category\n */\nexport const calculateNextScreeningDate = (lastTestDate: Date, category: string): Date | null => {\n  const interval = getScreeningInterval(category);\n  if (!interval) return null;\n\n  const nextDate = new Date(lastTestDate);\n  nextDate.setMonth(nextDate.getMonth() + interval.intervalMonths);\n  return nextDate;\n};\n\n/**\n * Check if a category is due for screening\n */\nexport const isScreeningDue = (\n  lastTestDate: Date,\n  category: string,\n  referenceDate: Date = new Date(),\n): boolean => {\n  const nextDate = calculateNextScreeningDate(lastTestDate, category);\n  if (!nextDate) return false;\n  return referenceDate >= nextDate;\n};\n\n/**\n * Get categories that are due for screening based on last test dates\n */\nexport const getDueCategories = (\n  lastTestDates: Record<string, Date>,\n  referenceDate: Date = new Date(),\n): CategoryScreeningInterval[] => {\n  return CATEGORY_SCREENING_INTERVALS.filter((interval) => {\n    const lastDate = lastTestDates[interval.category];\n    if (!lastDate) return true; // Never tested = due\n    return isScreeningDue(lastDate, interval.category, referenceDate);\n  });\n};\n\n/**\n * Get days until next screening for a category\n */\nexport const getDaysUntilScreening = (\n  lastTestDate: Date,\n  category: string,\n  referenceDate: Date = new Date(),\n): number | null => {\n  const nextDate = calculateNextScreeningDate(lastTestDate, category);\n  if (!nextDate) return null;\n\n  const diffTime = nextDate.getTime() - referenceDate.getTime();\n  return Math.ceil(diffTime / (1000 * 60 * 60 * 24));\n};\n","/**\n * Portuguese pluralization utility using native Intl.PluralRules\n * Provides automatic pluralization for common words used in the app\n */\n\nconst pluralRules = new Intl.PluralRules('pt-BR');\n\n/**\n * Dictionary of Portuguese words with their plural forms\n * Key is the singular form, value is the plural form\n */\nconst dictionary: Record<string, string> = {\n  // Common nouns\n  arquivo: 'arquivos',\n  biomarcador: 'biomarcadores',\n  // Past participles (masculine)\n  cadastrado: 'cadastrados',\n  // Past participles (feminine)\n  concluída: 'concluídas',\n  confirmado: 'confirmados',\n  convertido: 'convertidos',\n  convidado: 'convidados',\n  convite: 'convites',\n  disponível: 'disponíveis',\n  documento: 'documentos',\n  enviado: 'enviados',\n  exame: 'exames',\n  excluída: 'excluídas',\n\n  excluído: 'excluídos',\n  // Verbs (3rd person)\n  falhou: 'falharam',\n  falta: 'faltam',\n  ignorado: 'ignorados',\n  item: 'itens',\n  outro: 'outros',\n  página: 'páginas',\n  pendente: 'pendentes',\n  registro: 'registros',\n  removido: 'removidos',\n\n  resultado: 'resultados',\n  revisão: 'revisões',\n\n  revogado: 'revogados',\n  usuário: 'usuários',\n};\n\n/**\n * Get the plural form of a word from the dictionary\n * Falls back to adding 's' if word is not in dictionary\n */\nconst getPluralForm = (singular: string): string => {\n  return dictionary[singular] ?? `${singular}s`;\n};\n\n/**\n * Returns the correct singular or plural form based on count\n * Uses Intl.PluralRules for proper locale-aware pluralization\n *\n * @example\n * plural(1, 'usuário') // 'usuário'\n * plural(3, 'usuário') // 'usuários'\n * plural(0, 'registro') // 'registros'\n */\nexport const plural = (count: number, word: string): string => {\n  const rule = pluralRules.select(count);\n  return rule === 'one' ? word : getPluralForm(word);\n};\n\n/**\n * Returns count with the correct singular or plural form\n *\n * @example\n * pluralCount(1, 'usuário') // '1 usuário'\n * pluralCount(3, 'usuário') // '3 usuários'\n */\nexport const pluralCount = (count: number, word: string): string => {\n  return `${count} ${plural(count, word)}`;\n};\n\n/**\n * Returns the correct form for compound phrases (noun + adjective)\n * Both words are pluralized together\n *\n * @example\n * pluralPhrase(1, 'usuário', 'cadastrado') // 'usuário cadastrado'\n * pluralPhrase(3, 'usuário', 'cadastrado') // 'usuários cadastrados'\n * pluralPhrase(2, 'revisão', 'excluída') // 'revisões excluídas'\n */\nexport const pluralPhrase = (count: number, noun: string, adjective: string): string => {\n  const rule = pluralRules.select(count);\n  if (rule === 'one') {\n    return `${noun} ${adjective}`;\n  }\n  return `${getPluralForm(noun)} ${getPluralForm(adjective)}`;\n};\n\n/**\n * Returns count with the correct compound phrase form\n *\n * @example\n * pluralPhraseCount(1, 'usuário', 'cadastrado') // '1 usuário cadastrado'\n * pluralPhraseCount(3, 'convite', 'enviado') // '3 convites enviados'\n */\nexport const pluralPhraseCount = (count: number, noun: string, adjective: string): string => {\n  return `${count} ${pluralPhrase(count, noun, adjective)}`;\n};\n","/**\n * Helpers para identificadores brasileiros — CPF e CNS\n *\n * Validação, formatação e conversão para FHIR Identifier.\n * Algoritmos de validação baseados nas especificações oficiais:\n * - CPF: Receita Federal (mod-11, dois dígitos verificadores)\n * - CNS: Ministério da Saúde (mod-11 para definitivos, soma ponderada para provisórios)\n */\n\nimport type { FHIRIdentifier } from './fhir-types';\n\nconst CPF_SYSTEM = 'http://rnds.saude.gov.br/fhir/r4/NamingSystem/cpf';\nconst CNS_SYSTEM = 'http://rnds.saude.gov.br/fhir/r4/NamingSystem/cns';\n\n/**\n * Remove caracteres não-numéricos de uma string.\n */\nfunction digitsOnly(value: string): string {\n  return value.replace(/\\D/g, '');\n}\n\n/**\n * Valida um CPF brasileiro usando algoritmo mod-11.\n *\n * @param cpf — CPF com ou sem formatação (ex: \"123.456.789-09\" ou \"12345678909\")\n * @returns true se o CPF é estruturalmente válido\n */\nexport function validateCPF(cpf: string): boolean {\n  const digits = digitsOnly(cpf);\n\n  if (digits.length !== 11) return false;\n\n  // Rejeitar sequências de dígitos iguais (ex: 111.111.111-11)\n  if (/^(\\d)\\1{10}$/.test(digits)) return false;\n\n  // Primeiro dígito verificador\n  let sum = 0;\n  for (let i = 0; i < 9; i++) {\n    sum += Number(digits[i]) * (10 - i);\n  }\n  let remainder = (sum * 10) % 11;\n  if (remainder === 10) remainder = 0;\n  if (remainder !== Number(digits[9])) return false;\n\n  // Segundo dígito verificador\n  sum = 0;\n  for (let i = 0; i < 10; i++) {\n    sum += Number(digits[i]) * (11 - i);\n  }\n  remainder = (sum * 10) % 11;\n  if (remainder === 10) remainder = 0;\n  if (remainder !== Number(digits[10])) return false;\n\n  return true;\n}\n\n/**\n * Valida um CNS (Cartão Nacional de Saúde) brasileiro.\n *\n * CNS definitivos começam com 1 ou 2 (mod-11).\n * CNS provisórios começam com 7, 8 ou 9 (soma ponderada mod-11 = 0).\n *\n * @param cns — CNS com 15 dígitos\n * @returns true se o CNS é estruturalmente válido\n */\nexport function validateCNS(cns: string): boolean {\n  const digits = digitsOnly(cns);\n\n  if (digits.length !== 15) return false;\n\n  const firstDigit = digits[0]!;\n\n  // CNS deve começar com 1, 2 (definitivo) ou 7, 8, 9 (provisório)\n  if (!['1', '2', '7', '8', '9'].includes(firstDigit)) return false;\n\n  // Ambos os tipos usam soma ponderada mod-11 = 0\n  let sum = 0;\n  for (let i = 0; i < 15; i++) {\n    sum += Number(digits[i]) * (15 - i);\n  }\n  return sum % 11 === 0;\n}\n\n/**\n * Formata um CPF como XXX.XXX.XXX-XX.\n *\n * @param cpf — CPF com 11 dígitos (com ou sem formatação)\n * @returns CPF formatado ou a string original se inválido\n */\nexport function formatCPF(cpf: string): string {\n  const digits = digitsOnly(cpf);\n  if (digits.length !== 11) return cpf;\n  return `${digits.slice(0, 3)}.${digits.slice(3, 6)}.${digits.slice(6, 9)}-${digits.slice(9)}`;\n}\n\n/**\n * Formata um CNS como XXX XXXX XXXX XXXX.\n *\n * @param cns — CNS com 15 dígitos\n * @returns CNS formatado ou a string original se inválido\n */\nexport function formatCNS(cns: string): string {\n  const digits = digitsOnly(cns);\n  if (digits.length !== 15) return cns;\n  return `${digits.slice(0, 3)} ${digits.slice(3, 7)} ${digits.slice(7, 11)} ${digits.slice(11)}`;\n}\n\n/**\n * Converte um CPF para um FHIR Identifier.\n *\n * @param cpf — CPF com 11 dígitos (com ou sem formatação)\n * @returns FHIR Identifier com sistema RNDS para CPF\n * @throws Error se o CPF for inválido\n */\nexport function cpfToFHIRIdentifier(cpf: string): FHIRIdentifier {\n  if (!validateCPF(cpf)) {\n    throw new Error('CPF inválido');\n  }\n  return {\n    system: CPF_SYSTEM,\n    use: 'official',\n    value: digitsOnly(cpf),\n  };\n}\n\n/**\n * Converte um CNS para um FHIR Identifier.\n *\n * @param cns — CNS com 15 dígitos\n * @returns FHIR Identifier com sistema RNDS para CNS\n * @throws Error se o CNS for inválido\n */\nexport function cnsToFHIRIdentifier(cns: string): FHIRIdentifier {\n  if (!validateCNS(cns)) {\n    throw new Error('CNS inválido');\n  }\n  return {\n    system: CNS_SYSTEM,\n    use: 'official',\n    value: digitsOnly(cns),\n  };\n}\n","/**\n * URLs das extensões do IG do fhir-brasil.\n *\n * Quem emite a extensão e quem a lê precisam concordar literalmente na URL: um\n * consumidor procura a extensão pelo `url`, e uma grafia divergente faz o dado\n * sumir sem erro. O teste confere cada uma contra o `Id:` do FSH em\n * `ig/input/fsh/extensions/`, então extensão nova no IG sem constante aqui, ou\n * o inverso, reprova.\n */\n\n/** Canonical do IG, como está no `sushi-config.yaml`. */\nexport const IG_CANONICAL = 'https://fhir-brasil.dev.br/ig';\n\nconst structureDefinition = (id: string): string => `${IG_CANONICAL}/StructureDefinition/${id}`;\n\n/**\n * Extensões do IG, pela URL.\n *\n * As que têm partes (`extractionSource`, `extractionConfidence`, `asPrinted`)\n * levam as partes em `extension[]` aninhado, cada uma com `url` relativo: o\n * nome da parte, como `page` ou `reading`. Ver o FSH de cada uma.\n */\nexport const FHIR_BRASIL_EXTENSIONS = {\n  /** `Observation`: valor e faixa como impressos, quando a Observation traz outros. */\n  asPrinted: structureDefinition('as-printed'),\n  /** `Observation`: extraída de PDF via OCR. */\n  derivedFromOCR: structureDefinition('derived-from-ocr'),\n  /** `Observation`: confiança na leitura e na interpretação, de 0 a 1. */\n  extractionConfidence: structureDefinition('extraction-confidence'),\n  /** `Observation`: páginas, trecho citado e caixa do trecho no documento. */\n  extractionSource: structureDefinition('extraction-source'),\n  /** `DiagnosticReport`: lido da tabela de histórico de outro laudo. */\n  reprintedIn: structureDefinition('reprinted-in'),\n  /** `Observation`: lido do documento, mas substituído por outro valor do mesmo laudo. */\n  superseded: structureDefinition('superseded'),\n  /** `Observation`: unidade impressa ao lado de um resultado em texto. */\n  textValueUnit: structureDefinition('text-value-unit'),\n} as const;\n","/**\n * Código do tipo de amostra a partir do material impresso no laudo.\n *\n * O perfil `BRAmostraBiologica-1.0` da RNDS vincula `Specimen.type` ao ValueSet\n * `BRTipoAmostra-1.0` com força `required`, exige `type.coding` (1..1) e proíbe\n * `type.text` (0..0). Um `Specimen` só com o texto do laudo não passa, e é o que\n * a extração produzia.\n *\n * O ValueSet tem 63 códigos, e quase todos são de vigilância respiratória vindos\n * do GAL: swab nasofaríngeo, lavado brônquico, fragmento de órgão. Para laudo de\n * rotina sobram seis, e esses seis cobrem o que um painel de sangue e urina\n * imprime.\n *\n * Não há código para fezes no ValueSet. Isso não afeta a extração, cujo catálogo\n * não tem nenhum biomarcador de origem fecal: um parasitológico não vira\n * `Observation`, então não chega a pedir `Specimen`.\n *\n * @see https://rnds-fhir.saude.gov.br/StructureDefinition-BRAmostraBiologica-1.0.html\n * @see https://rnds-fhir.saude.gov.br/ValueSet-BRTipoAmostra-1.0.html\n */\nimport type { FHIRCoding } from './fhir-types';\n\n/** ValueSet ao qual `Specimen.type` está vinculado no `BRAmostraBiologica`. */\nexport const BR_TIPO_AMOSTRA_VALUESET = 'https://rnds-fhir.saude.gov.br/ValueSet/BRTipoAmostra-1.0';\n\n/**\n * CodeSystem dos códigos que este módulo emite.\n *\n * O ValueSet também inclui o `BRTipoAmostraGAL`, que traz \"Sangue\" e \"Sangue com\n * EDTA\" soltos. Ficaram de fora porque a URL canônica daquele CodeSystem não foi\n * confirmada na fonte, e código de terminologia não se deduz de slug. Material\n * assim cai no caminho de não mapeado até alguém abrir o IG e confirmar.\n */\nexport const HL7_SPECIMEN_TYPE_SYSTEM = 'http://terminology.hl7.org/CodeSystem/v2-0487';\n\n/**\n * Os `display` são cópia literal do ValueSet, com a caixa dele.\n *\n * A chave é o texto já normalizado, e por enquanto é só o próprio display. Não\n * há sinônimo inventado aqui: a extração copia o material verbatim do laudo, e a\n * lista de variações que os laboratórios de fato imprimem ainda não foi medida\n * (a captura de material entrou em produção em 05/09/2026). Variação real\n * observada entra depois, com o laudo que a produziu.\n */\nconst CODINGS: ReadonlyArray<{ code: string; display: string }> = [\n  { code: 'SER', display: 'Soro' },\n  { code: 'PLAS', display: 'Plasma' },\n  { code: 'WB', display: 'Sangue Total' },\n  { code: 'UR', display: 'Urina' },\n  { code: 'CSF', display: 'Líquor' },\n  { code: 'SAL', display: 'Saliva' },\n];\n\n/**\n * Caixa, acento e espaço sobrando não distinguem material.\n *\n * Só isso. Não separa `camelCase` nem troca barra por espaço, ao contrário do\n * normalizador de nomes de biomarcador: \"Soro/Plasma\" impresso numa linha só é\n * ambíguo de verdade, e escolher um dos dois seria inferência. Sem casar, ele\n * segue o caminho do não mapeado.\n *\n * Os caracteres invisíveis saem antes, e a divisão entre as duas regras é a do\n * próprio Unicode: `\\p{Cf}` são os de formatação, que não ocupam espaço e por\n * isso são apagados, e `\\s` são os de espaço, que são colapsados. A camada de\n * texto de PDF emite os dois tipos, e um U+200B no meio de \"Soro\" derruba o\n * casamento sem deixar rastro na tela.\n *\n * Vale a categoria em vez da lista porque a lista nunca fecha. Enumerando, o\n * hífen opcional (U+00AD) tinha ficado de fora, e ele aparece justamente onde\n * um nome composto como \"Sangue Total\" quebra de linha.\n */\nconst INVISIBLE = /\\p{Cf}/gu;\n\nconst normalize = (text: string): string =>\n  text\n    .replace(INVISIBLE, '')\n    .normalize('NFD')\n    .replace(/[\\u0300-\\u036f]/g, '')\n    .toLowerCase()\n    .replace(/\\s+/g, ' ')\n    .trim();\n\nconst BY_NORMALIZED_TEXT = new Map(\n  CODINGS.map(({ code, display }) => [\n    normalize(display),\n    { code, display, system: HL7_SPECIMEN_TYPE_SYSTEM } satisfies FHIRCoding,\n  ]),\n);\n\n/**\n * Coding do ValueSet para o material impresso, ou `undefined` sem casar.\n *\n * `undefined` é resposta legítima e não erro: o laudo pode trazer um material\n * fora do ValueSet, ou uma grafia que ninguém viu ainda. Quem chama decide o que\n * fazer, e a decisão que não existe é preencher com um código aproximado.\n */\nexport const specimenTypeCoding = (text: string): FHIRCoding | undefined =>\n  BY_NORMALIZED_TEXT.get(normalize(text));\n"]}

package/dist/index.d.cts

@@ -1,6 +1,6 @@
-import { I as InterventionData, A as Addressable, U as UserProfileData } from './converter-DP8VkkO3.cjs';
-export { B as BUNDLE_BASE_URL, F as Flag, G as Gender, L as LabObservationData, a as LabReportData, O as OverallStatus, e as entryFullUrl, l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-DP8VkkO3.cjs';
-export { BIOMARKER_DEFINITIONS, BiomarkerDefinition, BiomarkerSearchPattern, CAC_INDICATOR_CODES, DEXA_CATEGORIES, DEXA_INDICATOR_CODES, SupportedBiomarker, codeToLoinc, filterVisibleBiomarkers, findCodeByName, generateCacFullReference, generateDexaFullReference, generateFilteredLLMReference, generateLLMReference, getAllCodes, getAllDefinitions, getAllLoincCodes, getAllSearchPatterns, getBiomarkersByCategory, getBiomarkersForCategories, getDefinitionByCode, getDefinitionByLoinc, getDefinitionsBySex, getSexForCode, getVisibleDefinitions, isBiomarkerVisible, isCacDocument, isDexaDocument, isValidCode, isValidLoinc, loincToCode, normalizeCode, toBiomarkerTests, validateLoincNameMatch } from './biomarkers.cjs';
+import { I as InterventionData, A as Addressable, U as UserProfileData } from './converter-Dlwb6OfB.cjs';
+export { B as BUNDLE_BASE_URL, F as Flag, G as Gender, L as LabObservationData, a as LabReportData, O as OverallStatus, e as entryFullUrl, l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-Dlwb6OfB.cjs';
+export { BIOMARKER_DEFINITIONS, BiomarkerDefinition, BiomarkerSearchPattern, CAC_INDICATOR_CODES, DEXA_CATEGORIES, DEXA_INDICATOR_CODES, MethodVariant, SupportedBiomarker, codeToLoinc, filterVisibleBiomarkers, findCodeByName, generateCacFullReference, generateDexaFullReference, generateFilteredLLMReference, generateLLMReference, getAllCodes, getAllDefinitions, getAllLoincCodes, getAllSearchPatterns, getBiomarkersByCategory, getBiomarkersForCategories, getDefinitionByCode, getDefinitionByLoinc, getDefinitionsBySex, getSexForCode, getVisibleDefinitions, isBiomarkerVisible, isCacDocument, isDexaDocument, isValidCode, isValidLoinc, loincToCode, methodVariantOf, normalizeCode, toBiomarkerTests, validateLoincNameMatch } from './biomarkers.cjs';
 export { BIOMARKER_DEFAULT_UNIT, BIOMARKER_UNITS, BiomarkerUnitConfig, ConversionResult, UNIT_TO_UCUM, convertUnit, getCanonicalUnit, getDefaultUnit, getSIUnit, isUcumCode, resolveUcum, unitToUCUM } from './units.cjs';
 import { F as FHIRMedicationStatement, a as FHIRObservation, b as FHIRBundle, c as FHIRIdentifier, d as FHIRCoding } from './fhir-types-Cn5WFbOI.cjs';
 export { e as FHIRAddress, f as FHIRAnnotation, g as FHIRAttachment, h as FHIRBundleEntry, i as FHIRCodeableConcept, j as FHIRContactPoint, k as FHIRDiagnosticReport, l as FHIRHumanName, m as FHIRPatient, n as FHIRPeriod, o as FHIRQuantity, p as FHIRReference, q as FHIRReferenceRange } from './fhir-types-Cn5WFbOI.cjs';

package/dist/index.d.ts

@@ -1,6 +1,6 @@
-import { I as InterventionData, A as Addressable, U as UserProfileData } from './converter-UygMzWlL.js';
-export { B as BUNDLE_BASE_URL, F as Flag, G as Gender, L as LabObservationData, a as LabReportData, O as OverallStatus, e as entryFullUrl, l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-UygMzWlL.js';
-export { BIOMARKER_DEFINITIONS, BiomarkerDefinition, BiomarkerSearchPattern, CAC_INDICATOR_CODES, DEXA_CATEGORIES, DEXA_INDICATOR_CODES, SupportedBiomarker, codeToLoinc, filterVisibleBiomarkers, findCodeByName, generateCacFullReference, generateDexaFullReference, generateFilteredLLMReference, generateLLMReference, getAllCodes, getAllDefinitions, getAllLoincCodes, getAllSearchPatterns, getBiomarkersByCategory, getBiomarkersForCategories, getDefinitionByCode, getDefinitionByLoinc, getDefinitionsBySex, getSexForCode, getVisibleDefinitions, isBiomarkerVisible, isCacDocument, isDexaDocument, isValidCode, isValidLoinc, loincToCode, normalizeCode, toBiomarkerTests, validateLoincNameMatch } from './biomarkers.js';
+import { I as InterventionData, A as Addressable, U as UserProfileData } from './converter-CTj83kPz.js';
+export { B as BUNDLE_BASE_URL, F as Flag, G as Gender, L as LabObservationData, a as LabReportData, O as OverallStatus, e as entryFullUrl, l as labObservationToFHIR, b as labReportToFHIR, c as labResultToFHIRBundle, u as userProfileToFHIR } from './converter-CTj83kPz.js';
+export { BIOMARKER_DEFINITIONS, BiomarkerDefinition, BiomarkerSearchPattern, CAC_INDICATOR_CODES, DEXA_CATEGORIES, DEXA_INDICATOR_CODES, MethodVariant, SupportedBiomarker, codeToLoinc, filterVisibleBiomarkers, findCodeByName, generateCacFullReference, generateDexaFullReference, generateFilteredLLMReference, generateLLMReference, getAllCodes, getAllDefinitions, getAllLoincCodes, getAllSearchPatterns, getBiomarkersByCategory, getBiomarkersForCategories, getDefinitionByCode, getDefinitionByLoinc, getDefinitionsBySex, getSexForCode, getVisibleDefinitions, isBiomarkerVisible, isCacDocument, isDexaDocument, isValidCode, isValidLoinc, loincToCode, methodVariantOf, normalizeCode, toBiomarkerTests, validateLoincNameMatch } from './biomarkers.js';
 export { BIOMARKER_DEFAULT_UNIT, BIOMARKER_UNITS, BiomarkerUnitConfig, ConversionResult, UNIT_TO_UCUM, convertUnit, getCanonicalUnit, getDefaultUnit, getSIUnit, isUcumCode, resolveUcum, unitToUCUM } from './units.js';
 import { F as FHIRMedicationStatement, a as FHIRObservation, b as FHIRBundle, c as FHIRIdentifier, d as FHIRCoding } from './fhir-types-Cn5WFbOI.js';
 export { e as FHIRAddress, f as FHIRAnnotation, g as FHIRAttachment, h as FHIRBundleEntry, i as FHIRCodeableConcept, j as FHIRContactPoint, k as FHIRDiagnosticReport, l as FHIRHumanName, m as FHIRPatient, n as FHIRPeriod, o as FHIRQuantity, p as FHIRReference, q as FHIRReferenceRange } from './fhir-types-Cn5WFbOI.js';

package/dist/index.js

@@ -5,19 +5,19 @@ import {
   labReportToFHIR,
   labResultToFHIRBundle,
   userProfileToFHIR
-} from "./chunk-K3VZ3F5Z.js";
+} from "./chunk-TLF3IVSN.js";
 import {
   MAX_FILE_SIZE,
   MAX_OBSERVATIONS,
   extractObservationsFromBundle,
   mapFHIRObservationToInternal,
   processImportBundle
-} from "./chunk-NJM45WAH.js";
+} from "./chunk-6QUGBBV2.js";
 import {
   validateFHIRDiagnosticReport,
   validateFHIRImportBundle,
   validateFHIRObservation
-} from "./chunk-E6MXDQXW.js";
+} from "./chunk-XT635TWP.js";
 import {
   BIOMARKER_CODE_SYSTEM,
   LOINC_SYSTEM
@@ -31,7 +31,7 @@ import {
   getRangeDirection,
   getReferenceRange,
   referenceRangeMeaning
-} from "./chunk-P4G534AQ.js";
+} from "./chunk-O3FXUPW3.js";
 import {
   SOURCE_REGISTRY,
   extractSourceKey
@@ -47,7 +47,7 @@ import {
   isUcumCode,
   resolveUcum,
   unitToUCUM
-} from "./chunk-Q3H5C6UR.js";
+} from "./chunk-U2XW6DY4.js";
 import {
   BIOMARKER_DEFINITIONS,
   CAC_INDICATOR_CODES,
@@ -77,10 +77,11 @@ import {
   isValidCode,
   isValidLoinc,
   loincToCode,
+  methodVariantOf,
   normalizeCode,
   toBiomarkerTests,
   validateLoincNameMatch
-} from "./chunk-4FKZG5GZ.js";
+} from "./chunk-KQ4CX67G.js";
 
 // src/category-groups.ts
 var CATEGORY_GROUPS = {
@@ -734,6 +735,7 @@ export {
   listMappedSubcategories,
   loincToCode,
   mapFHIRObservationToInternal,
+  methodVariantOf,
   normalizeCode,
   plural,
   pluralCount,