@precisa-saude/fhir 0.34.0 → 0.35.0

package/dist/{chunk-5RC7C7HJ.cjs.map → chunk-LNL5QSHP.cjs.map}

@@ -1 +1 @@
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* Unit Mappings and Biomarker Unit Definitions\n *\n * Maps units to UCUM format, provides default units for biomarkers,\n * and defines canonical/SI unit configurations with aliases.\n */\n\nimport { BIOMARKER_DEFINITIONS } from './biomarkers';\n\n// ─── UCUM Mappings ───────────────────────────────────────────────────────────\n\n/**\n * Grafia impressa → código UCUM (Unified Code for Units of Measure).\n *\n * É a segunda fonte de `resolveUcum`, atrás de `BIOMARKER_UNITS`, e a única\n * para unidade que nenhum biomarcador configura. Cobre toda unidade declarada\n * em `biomarkers.ts`: o teste `loinc-axes.test.ts` confere isso, porque uma\n * unidade sem entrada aqui saía no FHIR como `code` sob o system do UCUM sem\n * ser UCUM (`uIU/mL`, `K/uL`, `razão`).\n *\n * `[IU]` e `[iU]` são o mesmo átomo no UCUM, nas grafias sensível e\n * insensível a caixa; esta tabela usa `[IU]` e `BIOMARKER_UNITS` usa `[iU]`.\n *\n * @see https://ucum.org/\n */\nexport const UNIT_TO_UCUM: Record<string, string> = {\n  // Dimensionless / special measurements\n  '[pH]': '[pH]',\n  '{index}': '{index}',\n  '{ratio}': '{ratio}',\n  '{score}': '{score}',\n  '{specific gravity}': '{specific gravity}',\n\n  '/HPF': '/[HPF]',\n  '/LPF': '/[LPF]',\n  '/µL': '/uL',\n  // Percentage\n  '%': '%',\n  // Count units\n  '10³/µL': '10*3/uL',\n  '10⁶/µL': '10*6/uL',\n  Angstrom: 'Ao',\n  AU: '{score}',\n  cm: 'cm',\n  'cm³': 'cm3',\n  deg: 'deg',\n  // Volume\n  fL: 'fL',\n  g: 'g',\n  'g/cm²': 'g/cm2',\n\n  // Mass concentration\n  'g/dL': 'g/dL',\n  'g/L': 'g/L',\n  'IU/L': '[IU]/L',\n  'IU/mL': '[IU]/mL',\n  'K/uL': '10*3/uL',\n  'kcal/d': 'kcal/d',\n  kg: 'kg',\n  'kg/m2': 'kg/m2',\n  'kg/m²': 'kg/m2',\n  'kU/L': 'k[IU]/L',\n  L: 'L',\n  'M/uL': '10*6/uL',\n  'mcg/dL': 'ug/dL',\n  'mcg/L': 'ug/L',\n  'mcg/mL': 'ug/mL',\n  // Molar concentration\n  'mEq/L': 'meq/L',\n\n  mg: 'mg',\n  'mg/dL': 'mg/dL',\n  'mg/g': 'mg/g',\n  'mg/L': 'mg/L',\n  'mIU/L': 'm[IU]/L',\n  'mIU/mL': 'm[IU]/mL',\n  mL: 'mL',\n  'mL/min/1.73m²': 'mL/min/{1.73_m2}',\n  mm: 'mm',\n  'mm/h': 'mm/h',\n  'mm/hr': 'mm/h',\n  'mmol/L': 'mmol/L',\n  'mUI/L': 'm[IU]/L',\n  'mUI/mL': 'm[IU]/mL',\n\n  ng: 'ng',\n\n  'ng/dL': 'ng/dL',\n  'ng/L': 'ng/L',\n  'ng/mL': 'ng/mL',\n  'nmol/L': 'nmol/L',\n  // Mass\n  pg: 'pg',\n\n  'pg/mL': 'pg/mL',\n  pH: '[pH]',\n  'pmol/L': 'pmol/L',\n  razão: '{ratio}',\n  score: '{score}',\n  segundos: 's',\n  // Enzyme activity\n  U: 'U',\n  'U/L': 'U/L',\n  // Special units\n  'U/mL': 'U/mL',\n  'ug/dL': 'ug/dL',\n  'ug/L': 'ug/L',\n  'UI/L': '[IU]/L',\n\n  'UI/mL': '[IU]/mL',\n  'uIU/mL': 'u[IU]/mL',\n  'umol/L': 'umol/L',\n\n  µg: 'ug',\n  'µg/dL': 'ug/dL',\n  'µg/L': 'ug/L',\n  'µmol/L': 'umol/L',\n  'µUI/mL': 'u[IU]/mL',\n  índice: '{index}',\n};\n\n/**\n * Unidades adimensionais de urina, que a definição não declara porque o laudo\n * não as imprime: a densidade sai como `1.020` e o pH como `6.0`, sem unidade.\n * Quando o laudo não traz unidade, o FHIR ainda precisa de uma, e estas são\n * as do UCUM.\n */\nconst DIMENSIONLESS_DEFAULTS: Record<string, string> = {\n  pH_Urine: '[pH]',\n  SpecificGravity_Urine: '{specific gravity}',\n};\n\n/**\n * Unidade padrão de cada biomarcador, usada quando o laudo não imprime uma.\n *\n * Derivada de `unit` em `biomarkers.ts`, que é a fonte única. Até out/2026\n * era uma segunda tabela escrita à mão, e as duas divergiam: TSH era\n * `µUI/mL` aqui e `uIU/mL` lá, ferro era `µg/dL` aqui e `mcg/dL` lá. Duas\n * fontes para a mesma unidade é o que faz o `fhir-bio units` e o `fhir-bio\n * range` responderem coisas diferentes para o mesmo código.\n */\nexport const BIOMARKER_DEFAULT_UNIT: Record<string, string> = {\n  ...Object.fromEntries(\n    BIOMARKER_DEFINITIONS.filter((b) => b.unit).map((b) => [b.code, b.unit as string]),\n  ),\n  ...DIMENSIONLESS_DEFAULTS,\n};\n\n/**\n * Convert unit to UCUM format\n *\n * Devolve a entrada intacta quando não conhece a unidade. Para montar um\n * `Quantity` FHIR use `resolveUcum`, que diz \"não sei\" em vez de devolver\n * uma grafia qualquer como se fosse UCUM.\n */\nexport function unitToUCUM(unit: string): string {\n  return UNIT_TO_UCUM[unit] || unit;\n}\n\n/**\n * Get default unit for a biomarker code\n * @param biomarkerCode - The biomarker code (e.g., \"Glucose\", \"HbA1c\")\n * @returns The default unit or empty string if not found\n */\nexport function getDefaultUnit(biomarkerCode: string): string {\n  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || '';\n}\n\n// ─── UCUM syntax ─────────────────────────────────────────────────────────────\n\n/**\n * Átomos do UCUM que aparecem em laudo clínico, mais as bases do SI.\n *\n * Não é a tabela inteira do UCUM, que tem centenas de átomos. É a lista que\n * basta para dizer que `uIU/mL` não é UCUM (`IU` não é átomo; `[IU]` é) e que\n * `10*3/uL` é. Átomo fora desta lista cai em \"não é UCUM\", e o jeito certo de\n * aceitá-lo é acrescentá-lo aqui, com o laudo que o imprimiu.\n */\nconst UCUM_ATOMS = new Set([\n  'm',\n  'g',\n  's',\n  'L',\n  'l',\n  'mol',\n  'eq',\n  'U',\n  'cal',\n  'h',\n  'd',\n  'min',\n  'wk',\n  'mo',\n  'a',\n  'Ao',\n  'deg',\n  'K',\n  'A',\n  'N',\n  'Pa',\n  'J',\n  'W',\n  'Hz',\n  'V',\n  'C',\n  'osm',\n  't',\n  'u',\n  'bar',\n  'atm',\n  'rad',\n  'sr',\n  'cd',\n  'Bq',\n  'Gy',\n  'Sv',\n  'lm',\n  'lx',\n  'Cel',\n  'B',\n  'Np',\n]);\n\n/** Prefixos do UCUM, do yotta ao yocto. `da` (deca) é o único com duas letras. */\nconst UCUM_PREFIXES = new Set([\n  'Y',\n  'Z',\n  'E',\n  'P',\n  'T',\n  'G',\n  'M',\n  'k',\n  'h',\n  'da',\n  'd',\n  'c',\n  'm',\n  'u',\n  'n',\n  'p',\n  'f',\n  'a',\n  'z',\n  'y',\n]);\n\n/**\n * Um átomo com prefixo opcional: `g`, `mg`, `[IU]`, `u[IU]`, `10*3`, `%`.\n *\n * O prefixo só vale na frente de átomo métrico, e o UCUM marca essa\n * propriedade átomo a átomo. Aqui a regra é mais frouxa, prefixo na frente de\n * qualquer átomo, porque o que se quer pegar é grafia que não é UCUM de jeito\n * nenhum, e não o caso de borda `kdeg`.\n */\nfunction isUcumAtom(token: string): boolean {\n  if (token === '%' || /^10\\*-?\\d+$/.test(token) || /^\\d+$/.test(token)) return true;\n  // Átomo entre colchetes: `[IU]`, `[HPF]`, `[lb_av]`, `[pH]`. Com prefixo:\n  // `u[IU]`, `m[IU]`, `k[IU]`.\n  const bracket = /^([A-Za-z]{0,2})\\[[^[\\]{}\\s]+\\]$/.exec(token);\n  if (bracket) return bracket[1] === '' || UCUM_PREFIXES.has(bracket[1] as string);\n  if (UCUM_ATOMS.has(token)) return true;\n  for (const prefix of UCUM_PREFIXES) {\n    if (token.startsWith(prefix) && UCUM_ATOMS.has(token.slice(prefix.length))) return true;\n  }\n  return false;\n}\n\n/**\n * Um componente: átomo com expoente opcional e anotação opcional, ou anotação\n * sozinha. `m2`, `cm3`, `[in_i]3`, `mL{total}`, `{ratio}`.\n *\n * A anotação aceita qualquer caractere que não seja chave, que é o que a\n * especificação diz dela: texto sem interpretação. `{specific gravity}` passa\n * por isso, mesmo com espaço.\n */\nfunction isUcumComponent(token: string): boolean {\n  const m = /^(.*?)(\\{[^{}]*\\})?$/.exec(token);\n  if (!m) return false;\n  const [, body, annotation] = m;\n  if (!body) return annotation !== undefined;\n  const exp = /^(.+?)([+-]?\\d+)?$/.exec(body as string);\n  if (!exp) return false;\n  const [, atom, exponent] = exp;\n  // `10*3` termina em dígito e não tem expoente; o regex ganancioso já\n  // separou errado, então tenta o token inteiro como átomo primeiro.\n  if (isUcumAtom(body as string)) return true;\n  if (exponent === undefined) return false;\n  return isUcumAtom(atom as string);\n}\n\n/**\n * Diz se a string é sintaticamente UCUM: componentes ligados por `.` e `/`,\n * com `/` inicial permitido (`/[HPF]`).\n *\n * É sintaxe, não semântica: `K/uL` passa porque `K` é kelvin, e nada aqui sabe\n * que o laudo quis dizer milhares. É o que `resolveUcum` e `BIOMARKER_UNITS`\n * resolvem antes de a string chegar aqui. O que este check pega é o resto:\n * grafia em português, `µ` fora do ASCII, `IU` sem colchetes, `hr`.\n *\n * O `.` e o `/` só separam fora de chaves e colchetes: `mL/min/{1.73_m2}` tem\n * um ponto dentro da anotação, e `[in_i]` poderia ter um operador dentro do\n * átomo.\n */\nexport function isUcumCode(code: string): boolean {\n  if (!code || /[^\\x21-\\x7E ]/.test(code)) return false;\n  const terms: string[] = [];\n  let current = '';\n  let braces = 0;\n  let inBracket = false;\n  for (const ch of code) {\n    if (ch === '{') braces++;\n    else if (ch === '}') {\n      if (braces === 0) return false;\n      braces--;\n    } else if (ch === '[') inBracket = true;\n    else if (ch === ']') inBracket = false;\n    if ((ch === '.' || ch === '/') && braces === 0 && !inBracket) {\n      terms.push(current, ch);\n      current = '';\n      continue;\n    }\n    current += ch;\n  }\n  if (braces !== 0 || inBracket) return false;\n  terms.push(current);\n  // `/[HPF]` é `1/[HPF]` com o numerador implícito.\n  if (terms[0] === '' && terms[1] === '/') terms[0] = '1';\n\n  let expectOperand = true;\n  for (const t of terms) {\n    if (expectOperand) {\n      if (!isUcumComponent(t)) return false;\n    } else if (t !== '.' && t !== '/') {\n      return false;\n    }\n    expectOperand = !expectOperand;\n  }\n  return !expectOperand;\n}\n\n// ─── Biomarker Unit Configurations ───────────────────────────────────────────\n\n/** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */\n\nexport interface BiomarkerUnitConfig {\n  aliases: Record<string, string>;\n  canonicalUcum: string;\n  canonicalUnit: string;\n  molecularWeight?: number;\n  siUcum: string;\n  siUnit: string;\n}\n\nconst CBC_DIFF_ALIASES: Record<string, string> = {\n  '/ul': '/uL',\n  '/µl': '/uL',\n  '10*3/ul': 'K/uL',\n  'cells/ul': '/uL',\n  'cells/µl': '/uL',\n  'k/ul': 'K/uL',\n  'x10e3/ul': 'K/uL',\n};\nconst CBC_DIFF: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '10*3/uL',\n  canonicalUnit: 'K/uL',\n  siUcum: '10*3/uL',\n  siUnit: 'K/uL',\n};\nconst DEXA_KG_ALIASES: Record<string, string> = {\n  kg: 'kg',\n  lb: '[lb_av]',\n  lbs: '[lb_av]',\n};\nconst DEXA_KG: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'kg',\n  canonicalUnit: 'kg',\n  siUcum: 'kg',\n  siUnit: 'kg',\n};\n\n/**\n * Urine sediment units — Brazilian automated analyzers (Sysmex UF-series)\n * report in /mL while manual microscopy uses /HPF. Canonical unit is /HPF.\n */\nconst URINE_SEDIMENT_ALIASES: Record<string, string> = {\n  '/hpf': '/HPF',\n  '/ml': '/mL',\n};\nconst URINE_SEDIMENT: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '/[HPF]',\n  canonicalUnit: '/HPF',\n  siUcum: '/[HPF]',\n  siUnit: '/HPF',\n};\n\n/** Percentage biomarkers — canonical and SI both use %. */\nconst PERCENTAGE_ALIASES: Record<string, string> = { '%': '%', pct: '%', percent: '%' };\nconst PERCENTAGE: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '%',\n  canonicalUnit: '%',\n  siUcum: '%',\n  siUnit: '%',\n};\n\n/** Enzyme activity — canonical and SI both use U/L. */\nconst ENZYME_ALIASES: Record<string, string> = { 'iu/l': 'U/L', 'u/l': 'U/L' };\nconst ENZYME: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'U/L',\n  canonicalUnit: 'U/L',\n  siUcum: 'U/L',\n  siUnit: 'U/L',\n};\n\n/** Monovalent electrolytes — mEq/L ↔ mmol/L (1:1). */\nconst ELECTROLYTE_MONO_ALIASES: Record<string, string> = { 'meq/l': 'mEq/L', 'mmol/l': 'mmol/L' };\nconst ELECTROLYTE_MONO: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'meq/L',\n  canonicalUnit: 'mEq/L',\n  siUcum: 'mmol/L',\n  siUnit: 'mmol/L',\n};\n\n/** CAC scores — Agatston Units (AU), dimensionless. */\nconst CAC_ALIASES: Record<string, string> = { au: 'AU' };\nconst CAC: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '{score}',\n  canonicalUnit: 'AU',\n  siUcum: '{score}',\n  siUnit: 'AU',\n};\n\n/** nmol/L biomarkers — same unit for canonical and SI. */\nconst NMOL_L_ALIASES: Record<string, string> = { 'nmol/l': 'nmol/L' };\nconst NMOL_L: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'nmol/L',\n  canonicalUnit: 'nmol/L',\n  siUcum: 'nmol/L',\n  siUnit: 'nmol/L',\n};\n\nexport const BIOMARKER_UNITS: Record<string, BiomarkerUnitConfig> = {\n  AFP: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Albumin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  AlkalinePhosphatase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  ALT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AMH: {\n    aliases: { 'ng/ml': 'ng/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 12_500,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Amylase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AntiThyroglobulin: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AntiTPO: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AoA1: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AorticValveCalcium: { aliases: CAC_ALIASES, ...CAC },\n  ApoB: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AST: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Basophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  BilirubinDirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinIndirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinTotal: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  BMI: {\n    aliases: { 'kg/m2': 'kg/m²', 'kg/m²': 'kg/m²' },\n    canonicalUcum: 'kg/m2',\n    canonicalUnit: 'kg/m²',\n    siUcum: 'kg/m2',\n    siUnit: 'kg/m²',\n  },\n  BNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  CA125: {\n    aliases: { 'u/ml': 'U/mL' },\n    canonicalUcum: 'U/mL',\n    canonicalUnit: 'U/mL',\n    siUcum: 'U/mL',\n    siUnit: 'U/mL',\n  },\n  CAC_LAD: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LCX: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LMA: { aliases: CAC_ALIASES, ...CAC },\n  CAC_RCA: { aliases: CAC_ALIASES, ...CAC },\n  Calcium: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 40.08,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CEA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Chloride: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CK: { aliases: ENZYME_ALIASES, ...ENZYME },\n  CO2: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cortisol: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 362.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Creatinine: {\n    aliases: { 'mg/dl': 'mg/dL', 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 113.12,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  CRP: {\n    aliases: { 'mg/dl': 'mg/dL', 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  DHEAS: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 368.49,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  DHT: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 290.44,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  eGFR: {\n    aliases: {\n      'ml/min/1,73 m2': 'mL/min/1.73m²',\n      'ml/min/1.73m2': 'mL/min/1.73m²',\n      'ml/min/1.73m²': 'mL/min/1.73m²',\n    },\n    canonicalUcum: 'mL/min/{1.73_m2}',\n    canonicalUnit: 'mL/min/1.73m²',\n    siUcum: 'mL/min/{1.73_m2}',\n    siUnit: 'mL/min/1.73m²',\n  },\n  Eosinophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  EPADPADHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  ESR: {\n    aliases: { 'mm/h': 'mm/h', 'mm/hr': 'mm/h' },\n    canonicalUcum: 'mm/h',\n    canonicalUnit: 'mm/h',\n    siUcum: 'mm/h',\n    siUnit: 'mm/h',\n  },\n  Estradiol: {\n    aliases: { 'ng/dl': 'ng/dL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 272.38,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Ferritin: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  Folate: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 441.4,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  FSH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'm[iU]/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  GGT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Globulin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Glucose: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 180.156,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HbA1c: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Hct: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  HDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HDL_Large: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Hgb: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Homocysteine: {\n    aliases: { 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'umol/L',\n    canonicalUnit: 'µmol/L',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  // Imunoglobulinas: canônica em mg/dL, a unidade da faixa de referência\n  // (Tietz) e a que laboratórios brasileiros e americanos imprimem. g/L fica\n  // como unidade SI; a conversão é exata (g/L × 100 = mg/dL, em FIXED_FACTORS).\n  IgA: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  IgG: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  INR: {\n    aliases: { '{ratio}': '{ratio}' },\n    canonicalUcum: '{ratio}',\n    canonicalUnit: '{ratio}',\n    siUcum: '{ratio}',\n    siUnit: '{ratio}',\n  },\n  Insulin: {\n    aliases: {\n      'mu/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Iron: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  LDL_Medium: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_ParticleNumber: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_Peak_Size: {\n    aliases: { å: 'Ao', angstrom: 'Ao', ao: 'Ao', nm: 'nm' },\n    canonicalUcum: 'Ao',\n    canonicalUnit: 'Angstrom',\n    siUcum: 'nm',\n    siUnit: 'nm',\n  },\n  LDL_Small: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Lead: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 207.2,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Leptin: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  LH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'm[iU]/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Lipase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Lipoprotein_a: {\n    aliases: { 'mg/dl': 'mg/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'nmol/L',\n    canonicalUnit: 'nmol/L',\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Lymphocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MCH: {\n    aliases: { pg: 'pg' },\n    canonicalUcum: 'pg',\n    canonicalUnit: 'pg',\n    siUcum: 'pg',\n    siUnit: 'pg',\n  },\n  MCHC: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  MCV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Mercury: {\n    aliases: { 'mcg/l': 'µg/L', 'nmol/l': 'nmol/L', 'ug/l': 'µg/L', 'µg/l': 'µg/L' },\n    canonicalUcum: 'ug/L',\n    canonicalUnit: 'µg/L',\n    molecularWeight: 200.59,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Microalbumin_Urine: {\n    aliases: { 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  MMA: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Monocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MPV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Myeloperoxidase: {\n    aliases: { 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pmol/L',\n    canonicalUnit: 'pmol/L',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Neutrophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  // MW 386.65 = colesterol livre. Frações lipoproteicas são heterogêneas,\n  // mas a conversão mg/dL→mmol/L usa MW do colesterol por convenção clínica.\n  NonHDL_Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  NTproBNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  Omega3_DHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_DPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_EPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_AA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_LA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Potassium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Progesterone: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 314.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Prolactin: {\n    aliases: {\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  ProthrombinTime: {\n    aliases: { s: 's', sec: 's' },\n    canonicalUcum: 's',\n    canonicalUnit: 's',\n    siUcum: 's',\n    siUnit: 's',\n  },\n  PSA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  PSA_Free: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  RBC: {\n    aliases: {\n      '/ul': '/uL',\n      '/µl': '/uL',\n      '10*6/ul': 'M/uL',\n      'cells/ul': '/uL',\n      'm/ul': 'M/uL',\n      'milhões/mm3': 'M/uL',\n      'milhões/mm³': 'M/uL',\n      'x10e6/ul': 'M/uL',\n    },\n    canonicalUcum: '10*6/uL',\n    canonicalUnit: 'M/uL',\n    siUcum: '10*6/uL',\n    siUnit: 'M/uL',\n  },\n  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  RDW: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Reticulocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  RheumatoidFactor: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  SHBG: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Sodium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  T3Free: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 650.98,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T4Free: {\n    aliases: { 'ng/dl': 'ng/dL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 776.87,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T4Total: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 776.87,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Testosterone: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 288.42,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  TestosteroneFree: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 288.42,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  TIBC: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  TotalProtein: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Triglycerides: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 885.4,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  TroponinI: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  // Troponina T: canônica em ng/L (hs-cTnT). O ensaio convencional imprime em\n  // ng/mL, que é a mesma grandeza que µg/L; converte por fator exato\n  // (ng/mL × 1000 = ng/L, em FIXED_FACTORS). pg/mL é a mesma unidade que ng/L\n  // e entra como alias, como em VitaminB12.\n  TroponinT: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/l': 'ng/L',\n      'ng/ml': 'ng/mL',\n      'pg/ml': 'ng/L',\n      'ug/l': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/L',\n    canonicalUnit: 'ng/L',\n    siUcum: 'ng/L',\n    siUnit: 'ng/L',\n  },\n  TSH: {\n    aliases: {\n      'miu/l': 'uIU/mL',\n      'mui/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'm[iU]/L',\n    siUnit: 'mIU/L',\n  },\n  Urea: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 60.06,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  UricAcid: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 168.11,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  VATVolume: {\n    aliases: { cm3: 'cm3', 'cm³': 'cm3', in3: '[in_i]3', 'in³': '[in_i]3' },\n    canonicalUcum: 'cm3',\n    canonicalUnit: 'cm³',\n    siUcum: 'cm3',\n    siUnit: 'cm³',\n  },\n  VitaminB12: {\n    aliases: { 'ng/l': 'pg/mL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  VitaminD: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 384.64,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  VLDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n};\n\n/**\n * Get the canonical unit for a biomarker code.\n */\nexport function getCanonicalUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;\n}\n\n/**\n * Get the SI unit for a biomarker code.\n */\nexport function getSIUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.siUnit ?? null;\n}\n\n// ─── Unit Conversion ────────────────────────────────────────────────────────────\n\n/**\n * Normalize a unit string to its canonical display form for a given biomarker.\n * Returns the input unchanged if no alias is found.\n */\nfunction normalizeUnit(unit: string, config: BiomarkerUnitConfig): string {\n  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;\n}\n\n/**\n * Conversion factor tables for unit pairs that don't require molecular weight.\n * Key format: \"fromUnit -> toUnit\" (using canonical display forms).\n * Both directions must be listed explicitly — there is no auto-inversion.\n */\nconst FIXED_FACTORS: Record<string, number> = {\n  'g/dL -> g/L': 10,\n  'g/L -> g/dL': 0.1,\n  'g/L -> mg/dL': 100,\n  'mEq/L -> mmol/L': 1,\n  'mg/dL -> g/L': 0.01,\n  'mmol/L -> mEq/L': 1,\n  'ng/dL -> pg/mL': 10,\n  'ng/L -> ng/mL': 0.001,\n  'ng/mL -> ng/L': 1000,\n  'ng/mL -> µg/L': 1,\n  'pg/mL -> ng/dL': 0.1,\n  'µg/L -> ng/mL': 1,\n};\n\n/**\n * MW-based conversion definitions.\n * Each entry maps a (fromUnit, toUnit) pair to the formula:\n *   result = value × numerator / (MW × denominator)\n *\n * Common patterns:\n *   mg/dL  → mmol/L:  value × 10   / MW\n *   mg/dL  → µmol/L:  value × 10000 / MW  (or equivalently × 10 / MW × 1000)\n *   ng/mL  → nmol/L:  value × 1000 / MW\n *   pg/mL  → pmol/L:  value × 1000 / MW\n *   ng/dL  → nmol/L:  value × 10   / MW\n */\n/**\n * MW conversion entries. Each direction is explicit to avoid fragile inversion logic.\n * Formula: result = value × scale / MW  (when divideByMW is true)\n *          result = value × MW / scale  (when divideByMW is false)\n */\ninterface MWConversion {\n  divideByMW: boolean;\n  scale: number;\n}\n\nconst MW_CONVERSIONS: Record<string, MWConversion> = {\n  'mg/dL -> mmol/L': { divideByMW: true, scale: 10 },\n  'mg/dL -> µmol/L': { divideByMW: true, scale: 10_000 },\n  'mmol/L -> mg/dL': { divideByMW: false, scale: 10 },\n  'ng/dL -> nmol/L': { divideByMW: true, scale: 10 },\n  'ng/dL -> pmol/L': { divideByMW: true, scale: 10_000 },\n  'ng/mL -> nmol/L': { divideByMW: true, scale: 1000 },\n  'ng/mL -> pmol/L': { divideByMW: true, scale: 1_000_000 },\n  'nmol/L -> ng/dL': { divideByMW: false, scale: 10 },\n  'nmol/L -> ng/mL': { divideByMW: false, scale: 1000 },\n  'nmol/L -> µg/dL': { divideByMW: false, scale: 10_000 },\n  'nmol/L -> µg/L': { divideByMW: false, scale: 1000 },\n  'pg/mL -> pmol/L': { divideByMW: true, scale: 1000 },\n  'pmol/L -> ng/dL': { divideByMW: false, scale: 10_000 },\n  'pmol/L -> ng/mL': { divideByMW: false, scale: 1_000_000 },\n  'pmol/L -> pg/mL': { divideByMW: false, scale: 1000 },\n  'µg/dL -> nmol/L': { divideByMW: true, scale: 10_000 },\n  'µg/dL -> µmol/L': { divideByMW: true, scale: 10 },\n  'µg/L -> nmol/L': { divideByMW: true, scale: 1000 },\n  'µmol/L -> mg/dL': { divideByMW: false, scale: 10_000 },\n  'µmol/L -> µg/dL': { divideByMW: false, scale: 10 },\n};\n\nexport interface ConversionResult {\n  unit: string;\n  value: number;\n}\n\n/**\n * Convert a biomarker value between units.\n *\n * Supports:\n * - Fixed-factor conversions (e.g. ng/dL ↔ pg/mL, g/dL ↔ g/L)\n * - Molecular-weight-based conversions (e.g. mg/dL ↔ mmol/L, pg/mL ↔ pmol/L)\n *\n * @returns The converted value and target unit, or null if conversion is not possible.\n */\nexport function convertUnit(\n  value: number,\n  fromUnit: string,\n  toUnit: string,\n  biomarkerCode: string,\n): ConversionResult | null {\n  const config = BIOMARKER_UNITS[biomarkerCode];\n  if (!config) return null;\n\n  const normFrom = normalizeUnit(fromUnit, config);\n  const normTo = normalizeUnit(toUnit, config);\n\n  if (normFrom === normTo) {\n    return { unit: normTo, value };\n  }\n\n  const key = `${normFrom} -> ${normTo}`;\n\n  const fixedFactor = FIXED_FACTORS[key];\n  if (fixedFactor !== undefined) {\n    return { unit: normTo, value: value * fixedFactor };\n  }\n\n  const mwConv = MW_CONVERSIONS[key];\n  if (mwConv && config.molecularWeight) {\n    const result = mwConv.divideByMW\n      ? (value * mwConv.scale) / config.molecularWeight\n      : (value * config.molecularWeight) / mwConv.scale;\n    return { unit: normTo, value: result };\n  }\n\n  return null;\n}\n\n/**\n * Código UCUM para a unidade que o laudo imprimiu, ou `undefined`.\n *\n * Ordem: a configuração do biomarcador em `BIOMARKER_UNITS` (que já sabe que\n * `K/uL` de leucócito é `10*3/uL`), depois a tabela `UNIT_TO_UCUM`, e por\n * último a própria string, se for UCUM sintaticamente válido. Fora disso é\n * `undefined`, e o conversor deixa o `Quantity` só com `unit`: unidade que\n * não se sabe traduzir não sai sob `http://unitsofmeasure.org`.\n *\n * Até out/2026 o conversor só consultava a tabela e devolvia a entrada\n * intacta quando não achava, então `uIU/mL`, `K/uL` e `razão` saíam como\n * código UCUM, e os 85 `canonicalUcum` de `BIOMARKER_UNITS` não eram lidos\n * por ninguém fora de `units.ts`.\n */\nexport function resolveUcum(unit: string, biomarkerCode?: string): string | undefined {\n  if (!unit) return undefined;\n  const config = biomarkerCode ? BIOMARKER_UNITS[biomarkerCode] : undefined;\n  if (config) {\n    const normalized = normalizeUnit(unit, config);\n    if (normalized === config.canonicalUnit) return config.canonicalUcum;\n    if (normalized === config.siUnit) return config.siUcum;\n  }\n  const mapped = UNIT_TO_UCUM[unit];\n  if (mapped) return mapped;\n  return isUcumCode(unit) ? unit : undefined;\n}\n"]}
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* Unit Mappings and Biomarker Unit Definitions\n *\n * Maps units to UCUM format, provides default units for biomarkers,\n * and defines canonical/SI unit configurations with aliases.\n */\n\nimport { BIOMARKER_DEFINITIONS } from './biomarkers';\n\n// ─── UCUM Mappings ───────────────────────────────────────────────────────────\n\n/**\n * Grafia impressa → código UCUM (Unified Code for Units of Measure).\n *\n * É a segunda fonte de `resolveUcum`, atrás de `BIOMARKER_UNITS`, e a única\n * para unidade que nenhum biomarcador configura. Cobre toda unidade declarada\n * em `biomarkers.ts`: o teste `loinc-axes.test.ts` confere isso, porque uma\n * unidade sem entrada aqui saía no FHIR como `code` sob o system do UCUM sem\n * ser UCUM (`uIU/mL`, `K/uL`, `razão`).\n *\n * `[IU]` e `[iU]` são o mesmo átomo no UCUM, nas grafias sensível e\n * insensível a caixa; esta tabela usa `[IU]` e `BIOMARKER_UNITS` usa `[iU]`.\n *\n * @see https://ucum.org/\n */\nexport const UNIT_TO_UCUM: Record<string, string> = {\n  // Dimensionless / special measurements\n  '[pH]': '[pH]',\n  '{index}': '{index}',\n  '{ratio}': '{ratio}',\n  '{score}': '{score}',\n  '{specific gravity}': '{specific gravity}',\n\n  '/HPF': '/[HPF]',\n  '/LPF': '/[LPF]',\n  '/µL': '/uL',\n  // Percentage\n  '%': '%',\n  // Count units\n  '10³/µL': '10*3/uL',\n  '10⁶/µL': '10*6/uL',\n  Angstrom: 'Ao',\n  AU: '{score}',\n  cm: 'cm',\n  'cm³': 'cm3',\n  deg: 'deg',\n  // Volume\n  fL: 'fL',\n  g: 'g',\n  'g/cm²': 'g/cm2',\n\n  // Mass concentration\n  'g/dL': 'g/dL',\n  'g/L': 'g/L',\n  'IU/L': '[IU]/L',\n  'IU/mL': '[IU]/mL',\n  'K/uL': '10*3/uL',\n  'kcal/d': 'kcal/d',\n  kg: 'kg',\n  'kg/m2': 'kg/m2',\n  'kg/m²': 'kg/m2',\n  'kU/L': 'k[IU]/L',\n  L: 'L',\n  'M/uL': '10*6/uL',\n  'mcg/dL': 'ug/dL',\n  'mcg/L': 'ug/L',\n  'mcg/mL': 'ug/mL',\n  // Molar concentration\n  'mEq/L': 'meq/L',\n\n  mg: 'mg',\n  'mg/dL': 'mg/dL',\n  'mg/g': 'mg/g',\n  'mg/L': 'mg/L',\n  'mIU/L': 'm[IU]/L',\n  'mIU/mL': 'm[IU]/mL',\n  mL: 'mL',\n  'mL/min/1.73m²': 'mL/min/{1.73_m2}',\n  mm: 'mm',\n  'mm/h': 'mm/h',\n  'mm/hr': 'mm/h',\n  'mmol/L': 'mmol/L',\n  'mUI/L': 'm[IU]/L',\n  'mUI/mL': 'm[IU]/mL',\n\n  ng: 'ng',\n\n  'ng/dL': 'ng/dL',\n  'ng/L': 'ng/L',\n  'ng/mL': 'ng/mL',\n  'nmol/L': 'nmol/L',\n  // Mass\n  pg: 'pg',\n\n  'pg/mL': 'pg/mL',\n  pH: '[pH]',\n  'pmol/L': 'pmol/L',\n  razão: '{ratio}',\n  score: '{score}',\n  segundos: 's',\n  // Enzyme activity\n  U: 'U',\n  'U/L': 'U/L',\n  // Special units\n  'U/mL': 'U/mL',\n  'ug/dL': 'ug/dL',\n  'ug/L': 'ug/L',\n  'UI/L': '[IU]/L',\n\n  'UI/mL': '[IU]/mL',\n  'uIU/mL': 'u[IU]/mL',\n  'umol/L': 'umol/L',\n\n  µg: 'ug',\n  'µg/dL': 'ug/dL',\n  'µg/L': 'ug/L',\n  'µmol/L': 'umol/L',\n  'µUI/mL': 'u[IU]/mL',\n  índice: '{index}',\n};\n\n/**\n * Unidades adimensionais de urina, que a definição não declara porque o laudo\n * não as imprime: a densidade sai como `1.020` e o pH como `6.0`, sem unidade.\n * Quando o laudo não traz unidade, o FHIR ainda precisa de uma, e estas são\n * as do UCUM.\n */\nconst DIMENSIONLESS_DEFAULTS: Record<string, string> = {\n  pH_Urine: '[pH]',\n  SpecificGravity_Urine: '{specific gravity}',\n};\n\n/**\n * Unidade padrão de cada biomarcador, usada quando o laudo não imprime uma.\n *\n * Derivada de `unit` em `biomarkers.ts`, que é a fonte única. Até out/2026\n * era uma segunda tabela escrita à mão, e as duas divergiam: TSH era\n * `µUI/mL` aqui e `uIU/mL` lá, ferro era `µg/dL` aqui e `mcg/dL` lá. Duas\n * fontes para a mesma unidade é o que faz o `fhir-bio units` e o `fhir-bio\n * range` responderem coisas diferentes para o mesmo código.\n */\nexport const BIOMARKER_DEFAULT_UNIT: Record<string, string> = {\n  ...Object.fromEntries(\n    BIOMARKER_DEFINITIONS.filter((b) => b.unit).map((b) => [b.code, b.unit as string]),\n  ),\n  ...DIMENSIONLESS_DEFAULTS,\n};\n\n/**\n * Convert unit to UCUM format\n *\n * Devolve a entrada intacta quando não conhece a unidade. Para montar um\n * `Quantity` FHIR use `resolveUcum`, que diz \"não sei\" em vez de devolver\n * uma grafia qualquer como se fosse UCUM.\n */\nexport function unitToUCUM(unit: string): string {\n  return UNIT_TO_UCUM[unit] || unit;\n}\n\n/**\n * Get default unit for a biomarker code\n * @param biomarkerCode - The biomarker code (e.g., \"Glucose\", \"HbA1c\")\n * @returns The default unit or empty string if not found\n */\nexport function getDefaultUnit(biomarkerCode: string): string {\n  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || '';\n}\n\n// ─── UCUM syntax ─────────────────────────────────────────────────────────────\n\n/**\n * Átomos do UCUM que aparecem em laudo clínico, mais as bases do SI.\n *\n * Não é a tabela inteira do UCUM, que tem centenas de átomos. É a lista que\n * basta para dizer que `uIU/mL` não é UCUM (`IU` não é átomo; `[IU]` é) e que\n * `10*3/uL` é. Átomo fora desta lista cai em \"não é UCUM\", e o jeito certo de\n * aceitá-lo é acrescentá-lo aqui, com o laudo que o imprimiu.\n */\nconst UCUM_ATOMS = new Set([\n  'm',\n  'g',\n  's',\n  'L',\n  'l',\n  'mol',\n  'eq',\n  'U',\n  'cal',\n  'h',\n  'd',\n  'min',\n  'wk',\n  'mo',\n  'a',\n  'Ao',\n  'deg',\n  'K',\n  'A',\n  'N',\n  'Pa',\n  'J',\n  'W',\n  'Hz',\n  'V',\n  'C',\n  'osm',\n  't',\n  'u',\n  'bar',\n  'atm',\n  'rad',\n  'sr',\n  'cd',\n  'Bq',\n  'Gy',\n  'Sv',\n  'lm',\n  'lx',\n  'Cel',\n  'B',\n  'Np',\n]);\n\n/** Prefixos do UCUM, do yotta ao yocto. `da` (deca) é o único com duas letras. */\nconst UCUM_PREFIXES = new Set([\n  'Y',\n  'Z',\n  'E',\n  'P',\n  'T',\n  'G',\n  'M',\n  'k',\n  'h',\n  'da',\n  'd',\n  'c',\n  'm',\n  'u',\n  'n',\n  'p',\n  'f',\n  'a',\n  'z',\n  'y',\n]);\n\n/**\n * Um átomo com prefixo opcional: `g`, `mg`, `[IU]`, `u[IU]`, `10*3`, `%`.\n *\n * O prefixo só vale na frente de átomo métrico, e o UCUM marca essa\n * propriedade átomo a átomo. Aqui a regra é mais frouxa, prefixo na frente de\n * qualquer átomo, porque o que se quer pegar é grafia que não é UCUM de jeito\n * nenhum, e não o caso de borda `kdeg`.\n */\nfunction isUcumAtom(token: string): boolean {\n  if (token === '%' || /^10\\*-?\\d+$/.test(token) || /^\\d+$/.test(token)) return true;\n  // Átomo entre colchetes: `[IU]`, `[HPF]`, `[lb_av]`, `[pH]`. Com prefixo:\n  // `u[IU]`, `m[IU]`, `k[IU]`.\n  const bracket = /^([A-Za-z]{0,2})\\[[^[\\]{}\\s]+\\]$/.exec(token);\n  if (bracket) return bracket[1] === '' || UCUM_PREFIXES.has(bracket[1] as string);\n  if (UCUM_ATOMS.has(token)) return true;\n  for (const prefix of UCUM_PREFIXES) {\n    if (token.startsWith(prefix) && UCUM_ATOMS.has(token.slice(prefix.length))) return true;\n  }\n  return false;\n}\n\n/**\n * Um componente: átomo com expoente opcional e anotação opcional, ou anotação\n * sozinha. `m2`, `cm3`, `[in_i]3`, `mL{total}`, `{ratio}`.\n *\n * A anotação aceita qualquer caractere que não seja chave, que é o que a\n * especificação diz dela: texto sem interpretação. `{specific gravity}` passa\n * por isso, mesmo com espaço.\n */\nfunction isUcumComponent(token: string): boolean {\n  const m = /^(.*?)(\\{[^{}]*\\})?$/.exec(token);\n  if (!m) return false;\n  const [, body, annotation] = m;\n  if (!body) return annotation !== undefined;\n  const exp = /^(.+?)([+-]?\\d+)?$/.exec(body as string);\n  if (!exp) return false;\n  const [, atom, exponent] = exp;\n  // `10*3` termina em dígito e não tem expoente; o regex ganancioso já\n  // separou errado, então tenta o token inteiro como átomo primeiro.\n  if (isUcumAtom(body as string)) return true;\n  if (exponent === undefined) return false;\n  return isUcumAtom(atom as string);\n}\n\n/**\n * Diz se a string é sintaticamente UCUM: componentes ligados por `.` e `/`,\n * com `/` inicial permitido (`/[HPF]`).\n *\n * É sintaxe, não semântica: `K/uL` passa porque `K` é kelvin, e nada aqui sabe\n * que o laudo quis dizer milhares. É o que `resolveUcum` e `BIOMARKER_UNITS`\n * resolvem antes de a string chegar aqui. O que este check pega é o resto:\n * grafia em português, `µ` fora do ASCII, `IU` sem colchetes, `hr`.\n *\n * O `.` e o `/` só separam fora de chaves e colchetes: `mL/min/{1.73_m2}` tem\n * um ponto dentro da anotação, e `[in_i]` poderia ter um operador dentro do\n * átomo.\n */\nexport function isUcumCode(code: string): boolean {\n  if (!code || /[^\\x21-\\x7E ]/.test(code)) return false;\n  const terms: string[] = [];\n  let current = '';\n  let braces = 0;\n  let inBracket = false;\n  for (const ch of code) {\n    if (ch === '{') braces++;\n    else if (ch === '}') {\n      if (braces === 0) return false;\n      braces--;\n    } else if (ch === '[') inBracket = true;\n    else if (ch === ']') inBracket = false;\n    if ((ch === '.' || ch === '/') && braces === 0 && !inBracket) {\n      terms.push(current, ch);\n      current = '';\n      continue;\n    }\n    current += ch;\n  }\n  if (braces !== 0 || inBracket) return false;\n  terms.push(current);\n  // `/[HPF]` é `1/[HPF]` com o numerador implícito.\n  if (terms[0] === '' && terms[1] === '/') terms[0] = '1';\n\n  let expectOperand = true;\n  for (const t of terms) {\n    if (expectOperand) {\n      if (!isUcumComponent(t)) return false;\n    } else if (t !== '.' && t !== '/') {\n      return false;\n    }\n    expectOperand = !expectOperand;\n  }\n  return !expectOperand;\n}\n\n// ─── Biomarker Unit Configurations ───────────────────────────────────────────\n\n/** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */\n\nexport interface BiomarkerUnitConfig {\n  aliases: Record<string, string>;\n  canonicalUcum: string;\n  canonicalUnit: string;\n  molecularWeight?: number;\n  siUcum: string;\n  siUnit: string;\n}\n\nconst CBC_DIFF_ALIASES: Record<string, string> = {\n  '/ul': '/uL',\n  '/µl': '/uL',\n  '10*3/ul': 'K/uL',\n  'cells/ul': '/uL',\n  'cells/µl': '/uL',\n  'k/ul': 'K/uL',\n  'x10e3/ul': 'K/uL',\n};\nconst CBC_DIFF: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '10*3/uL',\n  canonicalUnit: 'K/uL',\n  siUcum: '10*3/uL',\n  siUnit: 'K/uL',\n};\nconst DEXA_KG_ALIASES: Record<string, string> = {\n  kg: 'kg',\n  lb: '[lb_av]',\n  lbs: '[lb_av]',\n};\nconst DEXA_KG: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'kg',\n  canonicalUnit: 'kg',\n  siUcum: 'kg',\n  siUnit: 'kg',\n};\n\n/**\n * Urine sediment units — Brazilian automated analyzers (Sysmex UF-series)\n * report in /mL while manual microscopy uses /HPF. Canonical unit is /HPF.\n */\nconst URINE_SEDIMENT_ALIASES: Record<string, string> = {\n  '/hpf': '/HPF',\n  '/ml': '/mL',\n};\nconst URINE_SEDIMENT: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '/[HPF]',\n  canonicalUnit: '/HPF',\n  siUcum: '/[HPF]',\n  siUnit: '/HPF',\n};\n\n/** Percentage biomarkers — canonical and SI both use %. */\nconst PERCENTAGE_ALIASES: Record<string, string> = { '%': '%', pct: '%', percent: '%' };\nconst PERCENTAGE: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '%',\n  canonicalUnit: '%',\n  siUcum: '%',\n  siUnit: '%',\n};\n\n/** Enzyme activity — canonical and SI both use U/L. */\nconst ENZYME_ALIASES: Record<string, string> = { 'iu/l': 'U/L', 'u/l': 'U/L' };\nconst ENZYME: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'U/L',\n  canonicalUnit: 'U/L',\n  siUcum: 'U/L',\n  siUnit: 'U/L',\n};\n\n/** Monovalent electrolytes — mEq/L ↔ mmol/L (1:1). */\nconst ELECTROLYTE_MONO_ALIASES: Record<string, string> = { 'meq/l': 'mEq/L', 'mmol/l': 'mmol/L' };\nconst ELECTROLYTE_MONO: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'meq/L',\n  canonicalUnit: 'mEq/L',\n  siUcum: 'mmol/L',\n  siUnit: 'mmol/L',\n};\n\n/** CAC scores — Agatston Units (AU), dimensionless. */\nconst CAC_ALIASES: Record<string, string> = { au: 'AU' };\nconst CAC: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '{score}',\n  canonicalUnit: 'AU',\n  siUcum: '{score}',\n  siUnit: 'AU',\n};\n\n/** nmol/L biomarkers — same unit for canonical and SI. */\nconst NMOL_L_ALIASES: Record<string, string> = { 'nmol/l': 'nmol/L' };\nconst NMOL_L: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'nmol/L',\n  canonicalUnit: 'nmol/L',\n  siUcum: 'nmol/L',\n  siUnit: 'nmol/L',\n};\n\nexport const BIOMARKER_UNITS: Record<string, BiomarkerUnitConfig> = {\n  AFP: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Albumin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  AlkalinePhosphatase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  ALT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AMH: {\n    aliases: { 'ng/ml': 'ng/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 12_500,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Amylase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AntiThyroglobulin: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AntiTPO: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AoA1: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AorticValveCalcium: { aliases: CAC_ALIASES, ...CAC },\n  ApoB: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AST: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Basophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  BilirubinDirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinIndirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinTotal: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  BMI: {\n    aliases: { 'kg/m2': 'kg/m²', 'kg/m²': 'kg/m²' },\n    canonicalUcum: 'kg/m2',\n    canonicalUnit: 'kg/m²',\n    siUcum: 'kg/m2',\n    siUnit: 'kg/m²',\n  },\n  BNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  CA125: {\n    aliases: { 'u/ml': 'U/mL' },\n    canonicalUcum: 'U/mL',\n    canonicalUnit: 'U/mL',\n    siUcum: 'U/mL',\n    siUnit: 'U/mL',\n  },\n  CAC_LAD: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LCX: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LMA: { aliases: CAC_ALIASES, ...CAC },\n  CAC_RCA: { aliases: CAC_ALIASES, ...CAC },\n  Calcium: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 40.08,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CEA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Chloride: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CK: { aliases: ENZYME_ALIASES, ...ENZYME },\n  CO2: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cortisol: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 362.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Creatinine: {\n    aliases: { 'mg/dl': 'mg/dL', 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 113.12,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  CRP: {\n    aliases: { 'mg/dl': 'mg/dL', 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  DHEAS: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 368.49,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  DHT: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 290.44,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  eGFR: {\n    aliases: {\n      'ml/min/1,73 m2': 'mL/min/1.73m²',\n      'ml/min/1.73m2': 'mL/min/1.73m²',\n      'ml/min/1.73m²': 'mL/min/1.73m²',\n    },\n    canonicalUcum: 'mL/min/{1.73_m2}',\n    canonicalUnit: 'mL/min/1.73m²',\n    siUcum: 'mL/min/{1.73_m2}',\n    siUnit: 'mL/min/1.73m²',\n  },\n  Eosinophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  EPADPADHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  ESR: {\n    aliases: { 'mm/h': 'mm/h', 'mm/hr': 'mm/h' },\n    canonicalUcum: 'mm/h',\n    canonicalUnit: 'mm/h',\n    siUcum: 'mm/h',\n    siUnit: 'mm/h',\n  },\n  Estradiol: {\n    aliases: { 'ng/dl': 'ng/dL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 272.38,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Ferritin: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  Folate: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 441.4,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  FSH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'm[iU]/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  GGT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Globulin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Glucose: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 180.156,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HbA1c: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Hct: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  HDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HDL_Large: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Hgb: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Homocysteine: {\n    aliases: { 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'umol/L',\n    canonicalUnit: 'µmol/L',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  // Imunoglobulinas: canônica em mg/dL, a unidade da faixa de referência\n  // (Tietz) e a que laboratórios brasileiros e americanos imprimem. g/L fica\n  // como unidade SI; a conversão é exata (g/L × 100 = mg/dL, em FIXED_FACTORS).\n  IgA: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  IgG: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  INR: {\n    aliases: { '{ratio}': '{ratio}' },\n    canonicalUcum: '{ratio}',\n    canonicalUnit: '{ratio}',\n    siUcum: '{ratio}',\n    siUnit: '{ratio}',\n  },\n  Insulin: {\n    aliases: {\n      'mu/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Iron: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  LDL_Medium: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_ParticleNumber: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_Peak_Size: {\n    aliases: { å: 'Ao', angstrom: 'Ao', ao: 'Ao', nm: 'nm' },\n    canonicalUcum: 'Ao',\n    canonicalUnit: 'Angstrom',\n    siUcum: 'nm',\n    siUnit: 'nm',\n  },\n  LDL_Small: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Lead: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 207.2,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Leptin: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  LH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'm[iU]/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Lipase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Lipoprotein_a: {\n    aliases: { 'mg/dl': 'mg/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'nmol/L',\n    canonicalUnit: 'nmol/L',\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Lymphocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MCH: {\n    aliases: { pg: 'pg' },\n    canonicalUcum: 'pg',\n    canonicalUnit: 'pg',\n    siUcum: 'pg',\n    siUnit: 'pg',\n  },\n  MCHC: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  MCV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Mercury: {\n    aliases: { 'mcg/l': 'µg/L', 'nmol/l': 'nmol/L', 'ug/l': 'µg/L', 'µg/l': 'µg/L' },\n    canonicalUcum: 'ug/L',\n    canonicalUnit: 'µg/L',\n    molecularWeight: 200.59,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Microalbumin_Urine: {\n    aliases: { 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  MMA: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Monocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MPV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Myeloperoxidase: {\n    aliases: { 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pmol/L',\n    canonicalUnit: 'pmol/L',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Neutrophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  // MW 386.65 = colesterol livre. Frações lipoproteicas são heterogêneas,\n  // mas a conversão mg/dL→mmol/L usa MW do colesterol por convenção clínica.\n  NonHDL_Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  NTproBNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  Omega3_DHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_DPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_EPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_AA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_LA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Potassium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Progesterone: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 314.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Prolactin: {\n    aliases: {\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  ProthrombinTime: {\n    aliases: { s: 's', sec: 's' },\n    canonicalUcum: 's',\n    canonicalUnit: 's',\n    siUcum: 's',\n    siUnit: 's',\n  },\n  PSA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  PSA_Free: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  RBC: {\n    aliases: {\n      '/ul': '/uL',\n      '/µl': '/uL',\n      '10*6/ul': 'M/uL',\n      'cells/ul': '/uL',\n      'm/ul': 'M/uL',\n      'milhões/mm3': 'M/uL',\n      'milhões/mm³': 'M/uL',\n      'x10e6/ul': 'M/uL',\n    },\n    canonicalUcum: '10*6/uL',\n    canonicalUnit: 'M/uL',\n    siUcum: '10*6/uL',\n    siUnit: 'M/uL',\n  },\n  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  RDW: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Reticulocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  RheumatoidFactor: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  SHBG: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Sodium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  T3Free: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 650.98,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T4Free: {\n    aliases: { 'ng/dl': 'ng/dL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 776.87,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T4Total: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 776.87,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Testosterone: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 288.42,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  TestosteroneFree: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 288.42,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  TIBC: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  TotalProtein: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Triglycerides: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 885.4,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  TroponinI: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  // Troponina T: canônica em ng/L (hs-cTnT). O ensaio convencional imprime em\n  // ng/mL, que é a mesma grandeza que µg/L; converte por fator exato\n  // (ng/mL × 1000 = ng/L, em FIXED_FACTORS). pg/mL é a mesma unidade que ng/L\n  // e entra como alias, como em VitaminB12.\n  TroponinT: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/l': 'ng/L',\n      'ng/ml': 'ng/mL',\n      'pg/ml': 'ng/L',\n      'ug/l': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/L',\n    canonicalUnit: 'ng/L',\n    siUcum: 'ng/L',\n    siUnit: 'ng/L',\n  },\n  TSH: {\n    aliases: {\n      'miu/l': 'uIU/mL',\n      'mui/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'm[iU]/L',\n    siUnit: 'mIU/L',\n  },\n  Urea: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 60.06,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  UricAcid: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 168.11,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  VATVolume: {\n    aliases: { cm3: 'cm3', 'cm³': 'cm3', in3: '[in_i]3', 'in³': '[in_i]3' },\n    canonicalUcum: 'cm3',\n    canonicalUnit: 'cm³',\n    siUcum: 'cm3',\n    siUnit: 'cm³',\n  },\n  VitaminB12: {\n    aliases: { 'ng/l': 'pg/mL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  VitaminD: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 384.64,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  VLDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n};\n\n/**\n * Get the canonical unit for a biomarker code.\n */\nexport function getCanonicalUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;\n}\n\n/**\n * Get the SI unit for a biomarker code.\n */\nexport function getSIUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.siUnit ?? null;\n}\n\n// ─── Unit Conversion ────────────────────────────────────────────────────────────\n\n/**\n * Normalize a unit string to its canonical display form for a given biomarker.\n * Returns the input unchanged if no alias is found.\n */\nfunction normalizeUnit(unit: string, config: BiomarkerUnitConfig): string {\n  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;\n}\n\n/**\n * Conversion factor tables for unit pairs that don't require molecular weight.\n * Key format: \"fromUnit -> toUnit\" (using canonical display forms).\n * Both directions must be listed explicitly — there is no auto-inversion.\n */\nconst FIXED_FACTORS: Record<string, number> = {\n  'g/dL -> g/L': 10,\n  'g/L -> g/dL': 0.1,\n  'g/L -> mg/dL': 100,\n  'mEq/L -> mmol/L': 1,\n  'mg/dL -> g/L': 0.01,\n  'mmol/L -> mEq/L': 1,\n  'ng/dL -> pg/mL': 10,\n  'ng/L -> ng/mL': 0.001,\n  'ng/mL -> ng/L': 1000,\n  'ng/mL -> µg/L': 1,\n  'pg/mL -> ng/dL': 0.1,\n  'µg/L -> ng/mL': 1,\n};\n\n/**\n * MW-based conversion definitions.\n * Each entry maps a (fromUnit, toUnit) pair to the formula:\n *   result = value × numerator / (MW × denominator)\n *\n * Common patterns:\n *   mg/dL  → mmol/L:  value × 10   / MW\n *   mg/dL  → µmol/L:  value × 10000 / MW  (or equivalently × 10 / MW × 1000)\n *   ng/mL  → nmol/L:  value × 1000 / MW\n *   pg/mL  → pmol/L:  value × 1000 / MW\n *   ng/dL  → nmol/L:  value × 10   / MW\n */\n/**\n * MW conversion entries. Each direction is explicit to avoid fragile inversion logic.\n * Formula: result = value × scale / MW  (when divideByMW is true)\n *          result = value × MW / scale  (when divideByMW is false)\n */\ninterface MWConversion {\n  divideByMW: boolean;\n  scale: number;\n}\n\nconst MW_CONVERSIONS: Record<string, MWConversion> = {\n  'mg/dL -> mmol/L': { divideByMW: true, scale: 10 },\n  'mg/dL -> µmol/L': { divideByMW: true, scale: 10_000 },\n  'mmol/L -> mg/dL': { divideByMW: false, scale: 10 },\n  'ng/dL -> nmol/L': { divideByMW: true, scale: 10 },\n  'ng/dL -> pmol/L': { divideByMW: true, scale: 10_000 },\n  'ng/mL -> nmol/L': { divideByMW: true, scale: 1000 },\n  'ng/mL -> pmol/L': { divideByMW: true, scale: 1_000_000 },\n  'nmol/L -> ng/dL': { divideByMW: false, scale: 10 },\n  'nmol/L -> ng/mL': { divideByMW: false, scale: 1000 },\n  'nmol/L -> µg/dL': { divideByMW: false, scale: 10_000 },\n  'nmol/L -> µg/L': { divideByMW: false, scale: 1000 },\n  'pg/mL -> pmol/L': { divideByMW: true, scale: 1000 },\n  'pmol/L -> ng/dL': { divideByMW: false, scale: 10_000 },\n  'pmol/L -> ng/mL': { divideByMW: false, scale: 1_000_000 },\n  'pmol/L -> pg/mL': { divideByMW: false, scale: 1000 },\n  'µg/dL -> nmol/L': { divideByMW: true, scale: 10_000 },\n  'µg/dL -> µmol/L': { divideByMW: true, scale: 10 },\n  'µg/L -> nmol/L': { divideByMW: true, scale: 1000 },\n  'µmol/L -> mg/dL': { divideByMW: false, scale: 10_000 },\n  'µmol/L -> µg/dL': { divideByMW: false, scale: 10 },\n};\n\nexport interface ConversionResult {\n  unit: string;\n  value: number;\n}\n\n/**\n * Convert a biomarker value between units.\n *\n * Supports:\n * - Fixed-factor conversions (e.g. ng/dL ↔ pg/mL, g/dL ↔ g/L)\n * - Molecular-weight-based conversions (e.g. mg/dL ↔ mmol/L, pg/mL ↔ pmol/L)\n *\n * @returns The converted value and target unit, or null if conversion is not possible.\n */\nexport function convertUnit(\n  value: number,\n  fromUnit: string,\n  toUnit: string,\n  biomarkerCode: string,\n): ConversionResult | null {\n  const config = BIOMARKER_UNITS[biomarkerCode];\n  if (!config) return null;\n\n  const normFrom = normalizeUnit(fromUnit, config);\n  const normTo = normalizeUnit(toUnit, config);\n\n  if (normFrom === normTo) {\n    return { unit: normTo, value };\n  }\n\n  const key = `${normFrom} -> ${normTo}`;\n\n  const fixedFactor = FIXED_FACTORS[key];\n  if (fixedFactor !== undefined) {\n    return { unit: normTo, value: value * fixedFactor };\n  }\n\n  const mwConv = MW_CONVERSIONS[key];\n  if (mwConv && config.molecularWeight) {\n    const result = mwConv.divideByMW\n      ? (value * mwConv.scale) / config.molecularWeight\n      : (value * config.molecularWeight) / mwConv.scale;\n    return { unit: normTo, value: result };\n  }\n\n  return null;\n}\n\n/**\n * Código UCUM para a unidade que o laudo imprimiu, ou `undefined`.\n *\n * Ordem: a configuração do biomarcador em `BIOMARKER_UNITS` (que já sabe que\n * `K/uL` de leucócito é `10*3/uL`), depois a tabela `UNIT_TO_UCUM`, e por\n * último a própria string, se for UCUM sintaticamente válido. Fora disso é\n * `undefined`, e o conversor deixa o `Quantity` só com `unit`: unidade que\n * não se sabe traduzir não sai sob `http://unitsofmeasure.org`.\n *\n * Até out/2026 o conversor só consultava a tabela e devolvia a entrada\n * intacta quando não achava, então `uIU/mL`, `K/uL` e `razão` saíam como\n * código UCUM, e os 85 `canonicalUcum` de `BIOMARKER_UNITS` não eram lidos\n * por ninguém fora de `units.ts`.\n */\nexport function resolveUcum(unit: string, biomarkerCode?: string): string | undefined {\n  if (!unit) return undefined;\n  const config = biomarkerCode ? BIOMARKER_UNITS[biomarkerCode] : undefined;\n  if (config) {\n    const normalized = normalizeUnit(unit, config);\n    if (normalized === config.canonicalUnit) return config.canonicalUcum;\n    if (normalized === config.siUnit) return config.siUcum;\n  }\n  const mapped = UNIT_TO_UCUM[unit];\n  if (mapped) return mapped;\n  return isUcumCode(unit) ? unit : undefined;\n}\n"]}

package/dist/{chunk-P4G534AQ.js → chunk-O3FXUPW3.js}

@@ -1,6 +1,6 @@
 import {
   getCanonicalUnit
-} from "./chunk-Q3H5C6UR.js";
+} from "./chunk-U2XW6DY4.js";
 
 // src/reference-ranges.ts
 var biomarkerRangeDefinitions = {
@@ -2422,4 +2422,4 @@ export {
   getFallbackReferenceRange,
   applyFallbackReferenceRanges
 };
-//# sourceMappingURL=chunk-P4G534AQ.js.map
+//# sourceMappingURL=chunk-O3FXUPW3.js.map

package/dist/{chunk-K3VZ3F5Z.js → chunk-TLF3IVSN.js}

@@ -4,14 +4,15 @@ import {
 } from "./chunk-A6HR4XDK.js";
 import {
   referenceRangeMeaning
-} from "./chunk-P4G534AQ.js";
+} from "./chunk-O3FXUPW3.js";
 import {
   getDefaultUnit,
   resolveUcum
-} from "./chunk-Q3H5C6UR.js";
+} from "./chunk-U2XW6DY4.js";
 import {
-  codeToLoinc
-} from "./chunk-4FKZG5GZ.js";
+  codeToLoinc,
+  methodVariantOf
+} from "./chunk-KQ4CX67G.js";
 
 // src/bundle-urls.ts
 var BUNDLE_BASE_URL = "https://precisa-saude.com.br/fhir";
@@ -68,7 +69,8 @@ var buildReferenceRanges = (observation, quantity) => {
   );
 };
 function labObservationToFHIR(observation, patientId, laboratoryName) {
-  const loincCode = codeToLoinc(observation.biomarkerCode);
+  const methodLoinc = observation.methodLoinc && methodVariantOf(observation.biomarkerCode, observation.methodLoinc) ? observation.methodLoinc : void 0;
+  const loincCode = methodLoinc ?? codeToLoinc(observation.biomarkerCode);
   const sourceUnit = observation.unit || getDefaultUnit(observation.biomarkerCode) || observation.unit;
   const ucumUnit = resolveUcum(sourceUnit, observation.biomarkerCode);
   const quantity = (value) => ({
@@ -271,4 +273,4 @@ export {
   userProfileToFHIR,
   labResultToFHIRBundle
 };
-//# sourceMappingURL=chunk-K3VZ3F5Z.js.map
+//# sourceMappingURL=chunk-TLF3IVSN.js.map

package/dist/chunk-TLF3IVSN.js.map

@@ -0,0 +1 @@
+{"version":3,"sources":["../src/bundle-urls.ts","../src/converter.ts"],"sourcesContent":["/**\n * Endereço das entradas de um Bundle.\n *\n * O `fullUrl` identifica a entrada, e é contra ele que o validador resolve as\n * referências entre os recursos. Um Bundle com `subject.reference` valendo\n * `Patient/abc` só resolve se alguma entrada tiver `fullUrl` terminando em\n * `/Patient/abc`: a referência relativa é lida contra a base do `fullUrl` da\n * entrada, que é como os exemplos da própria HL7 montam Bundle de coleção.\n *\n * Antes o `fullUrl` era `urn:uuid:observation-<laudo>-<código>`, que erra duas\n * vezes. `urn:uuid:` exige a sintaxe de UUID e aquilo não era um UUID, e num\n * Bundle de entradas `urn:uuid:` a referência precisa repetir a URN inteira,\n * então nenhuma das relativas resolvia. Um laudo de 22 marcadores saía com 24\n * erros de URN e 22 referências perdidas.\n */\n/**\n * Recurso que já tem id, e por isso pode ser endereçado numa entrada.\n *\n * No FHIR o `id` é opcional, porque um recurso pode viajar sem identidade\n * própria. Numa entrada de Bundle ele não pode: sem id não há `fullUrl`, e sem\n * `fullUrl` nenhuma referência chega ao recurso. Os conversores daqui sempre\n * atribuem um, e o tipo passa a dizer isso em vez de deixar `undefined` chegar\n * até a montagem da URL.\n */\nexport type Addressable<T> = T & { id: string };\n\n/**\n * Base dos `fullUrl`.\n *\n * Não precisa responder a uma requisição: no FHIR o `fullUrl` é identidade, não\n * endereço de download. Fica sob um domínio nosso para não colidir com a\n * identidade de recurso de outra instituição, que é o risco real de usar\n * `example.org` em dado que sai da máquina.\n */\nexport const BUNDLE_BASE_URL = 'https://precisa-saude.com.br/fhir';\n\n/**\n * Monta o `fullUrl` a partir do próprio recurso.\n *\n * Recebe o recurso em vez do tipo e do id soltos de propósito. O defeito que\n * isto substitui nasceu de montar os dois lados em separado: o `fullUrl` dizia\n * `observation-demo-Hgb` enquanto o recurso tinha id `demo-Hgb`, e ninguém\n * percebeu porque nada obrigava os dois a concordarem.\n *\n * O parâmetro pede o mínimo que a URL consome, e não a união de recursos que\n * este pacote converte. Um Bundle pode carregar qualquer recurso do R4, e quem\n * acrescenta uma entrada de um tipo que não está nessa união (um `Specimen`,\n * por exemplo) precisa do mesmo endereço, senão monta o dele e as duas formas\n * divergem outra vez.\n */\nexport const entryFullUrl = (resource: Addressable<{ resourceType: string }>): string =>\n  `${BUNDLE_BASE_URL}/${resource.resourceType}/${resource.id}`;\n","/**\n * FHIR Converter\n *\n * Converts lab results to FHIR R4 DiagnosticReport and Observation resources.\n * See: https://hl7.org/fhir/diagnosticreport.html\n */\n\nimport { codeToLoinc, methodVariantOf } from './biomarkers';\nimport { type Addressable, entryFullUrl } from './bundle-urls';\nimport { BIOMARKER_CODE_SYSTEM, LOINC_SYSTEM } from './code-systems';\nimport type {\n  FHIRBundle,\n  FHIRDiagnosticReport,\n  FHIRObservation,\n  FHIRPatient,\n  FHIRQuantity,\n  FHIRReferenceRange,\n} from './fhir-types';\nimport { referenceRangeMeaning } from './reference-ranges';\nimport type { Flag, LabObservationData, LabReportData, UserProfileData } from './types';\nimport { getDefaultUnit, resolveUcum } from './units';\n\n// Re-export all types and functions\nexport * from './fhir-types';\n\n/**\n * Convert Flag to FHIR interpretation code\n */\nfunction interpretationCode(flag: Flag): string {\n  switch (flag) {\n    case 'H':\n      return 'H'; // High\n    case 'L':\n      return 'L'; // Low\n    default:\n      return 'N'; // Normal\n  }\n}\n\n/**\n * Convert Flag to FHIR interpretation display\n */\nfunction interpretationDisplay(flag: Flag): string {\n  switch (flag) {\n    case 'H':\n      return 'High';\n    case 'L':\n      return 'Low';\n    default:\n      return 'Normal';\n  }\n}\n\n/**\n * O `coding` do sexo, que vai **dentro** do CodeableConcept do `appliesTo`.\n *\n * O nome diz `CODING` e não `APPLIES_TO` de propósito: isto não é o valor do\n * campo, é uma entrada da lista de codificações dele. O embrulho acontece no\n * uso, em `{ coding: [SEX_CODING[sex]] }`.\n *\n * É o `AdministrativeGender`, e não o v3-ObservationInterpretation nem um\n * sistema nosso: um consumidor que já lê `Patient.gender` compara os dois sem\n * tabela de tradução no meio.\n */\nconst SEX_CODING = {\n  female: {\n    code: 'female',\n    display: 'Female',\n    system: 'http://hl7.org/fhir/administrative-gender',\n  },\n  male: { code: 'male', display: 'Male', system: 'http://hl7.org/fhir/administrative-gender' },\n} as const;\n\n/**\n * Monta as faixas de referência do `Observation`.\n *\n * Duas mudanças em relação ao que existia, e as duas são sobre não perder o que\n * o laudo imprimiu.\n *\n * **Um limite só já basta.** Antes a faixa só saía com os dois, e um laudo que\n * publica \"inferior a 190 mg/dL\" ou \"superior a 60 mL/min/1,73m²\" perdia o\n * campo inteiro. O R4 trata `low` e `high` como opcionais independentes e\n * documenta o caso de um lado só, e o importador deste mesmo pacote já lia\n * `low?.value` e `high?.value` com acesso opcional: a assimetria era só do\n * escritor. Ver PRE-430.\n *\n * **Mais de uma faixa, anotada.** Laudo com uma coluna de referência por sexo\n * passa a sair com as duas, cada uma com o seu `appliesTo`, em vez de o\n * pipeline escolher uma sem saber de quem é o exame. 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package/dist/{chunk-Q3H5C6UR.js → chunk-U2XW6DY4.js}

@@ -1,6 +1,6 @@
 import {
   BIOMARKER_DEFINITIONS
-} from "./chunk-4FKZG5GZ.js";
+} from "./chunk-KQ4CX67G.js";
 
 // src/units.ts
 var UNIT_TO_UCUM = {
@@ -1073,4 +1073,4 @@ export {
   convertUnit,
   resolveUcum
 };
-//# sourceMappingURL=chunk-Q3H5C6UR.js.map
+//# sourceMappingURL=chunk-U2XW6DY4.js.map

package/dist/{chunk-OAFAERDY.cjs → chunk-VMYB7KOE.cjs}

@@ -1,13 +1,13 @@
 "use strict";Object.defineProperty(exports, "__esModule", {value: true}); function _nullishCoalesce(lhs, rhsFn) { if (lhs != null) { return lhs; } else { return rhsFn(); } }
 
-var _chunk5RC7C7HJcjs = require('./chunk-5RC7C7HJ.cjs');
+var _chunkLNL5QSHPcjs = require('./chunk-LNL5QSHP.cjs');
 
 // src/validators.ts
 var UCUM_SYSTEM = "http://unitsofmeasure.org";
 function ucumErrors(quantity, where) {
   if (!quantity || quantity.system !== UCUM_SYSTEM) return [];
   if (!quantity.code) return [`${where}: UCUM system declared without a code`];
-  if (!_chunk5RC7C7HJcjs.isUcumCode.call(void 0, quantity.code)) {
+  if (!_chunkLNL5QSHPcjs.isUcumCode.call(void 0, quantity.code)) {
     return [`${where}: "${quantity.code}" is not a UCUM code`];
   }
   return [];
@@ -78,4 +78,4 @@ function validateFHIRImportBundle(data) {
 
 
 exports.validateFHIRDiagnosticReport = validateFHIRDiagnosticReport; exports.validateFHIRObservation = validateFHIRObservation; exports.validateFHIRImportBundle = validateFHIRImportBundle;
-//# sourceMappingURL=chunk-OAFAERDY.cjs.map
+//# sourceMappingURL=chunk-VMYB7KOE.cjs.map

package/dist/{chunk-OAFAERDY.cjs.map → chunk-VMYB7KOE.cjs.map}

@@ -1 +1 @@
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