@precisa-saude/fhir 0.32.0 → 0.34.0

package/dist/units.cjs

@@ -7,9 +7,10 @@
 
 
 
-var _chunkAZTZYOAVcjs = require('./chunk-AZTZYOAV.cjs');
 
 
+var _chunk5RC7C7HJcjs = require('./chunk-5RC7C7HJ.cjs');
+require('./chunk-T75NZM56.cjs');
 
 
 
@@ -17,5 +18,9 @@ var _chunkAZTZYOAVcjs = require('./chunk-AZTZYOAV.cjs');
 
 
 
-exports.BIOMARKER_DEFAULT_UNIT = _chunkAZTZYOAVcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_UNITS = _chunkAZTZYOAVcjs.BIOMARKER_UNITS; exports.UNIT_TO_UCUM = _chunkAZTZYOAVcjs.UNIT_TO_UCUM; exports.convertUnit = _chunkAZTZYOAVcjs.convertUnit; exports.getCanonicalUnit = _chunkAZTZYOAVcjs.getCanonicalUnit; exports.getDefaultUnit = _chunkAZTZYOAVcjs.getDefaultUnit; exports.getSIUnit = _chunkAZTZYOAVcjs.getSIUnit; exports.unitToUCUM = _chunkAZTZYOAVcjs.unitToUCUM;
+
+
+
+
+exports.BIOMARKER_DEFAULT_UNIT = _chunk5RC7C7HJcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_UNITS = _chunk5RC7C7HJcjs.BIOMARKER_UNITS; exports.UNIT_TO_UCUM = _chunk5RC7C7HJcjs.UNIT_TO_UCUM; exports.convertUnit = _chunk5RC7C7HJcjs.convertUnit; exports.getCanonicalUnit = _chunk5RC7C7HJcjs.getCanonicalUnit; exports.getDefaultUnit = _chunk5RC7C7HJcjs.getDefaultUnit; exports.getSIUnit = _chunk5RC7C7HJcjs.getSIUnit; exports.isUcumCode = _chunk5RC7C7HJcjs.isUcumCode; exports.resolveUcum = _chunk5RC7C7HJcjs.resolveUcum; exports.unitToUCUM = _chunk5RC7C7HJcjs.unitToUCUM;
 //# sourceMappingURL=units.cjs.map

package/dist/units.cjs.map

@@ -1 +1 @@
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+{"version":3,"sources":["/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/units.cjs"],"names":[],"mappings":"AAAA;AACE;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACF,wDAA6B;AAC7B,gCAA6B;AAC7B;AACE;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACA;AACF,yjBAAC","file":"/home/runner/work/fhir-brasil/fhir-brasil/packages/core/dist/units.cjs"}

package/dist/units.d.cts

@@ -5,17 +5,36 @@
  * and defines canonical/SI unit configurations with aliases.
  */
 /**
- * Map units to UCUM (Unified Code for Units of Measure)
- * See: https://ucum.org/
+ * Grafia impressa → código UCUM (Unified Code for Units of Measure).
+ *
+ * É a segunda fonte de `resolveUcum`, atrás de `BIOMARKER_UNITS`, e a única
+ * para unidade que nenhum biomarcador configura. Cobre toda unidade declarada
+ * em `biomarkers.ts`: o teste `loinc-axes.test.ts` confere isso, porque uma
+ * unidade sem entrada aqui saía no FHIR como `code` sob o system do UCUM sem
+ * ser UCUM (`uIU/mL`, `K/uL`, `razão`).
+ *
+ * `[IU]` e `[iU]` são o mesmo átomo no UCUM, nas grafias sensível e
+ * insensível a caixa; esta tabela usa `[IU]` e `BIOMARKER_UNITS` usa `[iU]`.
+ *
+ * @see https://ucum.org/
  */
 declare const UNIT_TO_UCUM: Record<string, string>;
 /**
- * Default units for biomarkers when source data doesn't provide one
- * These are the most common units used in Brazilian labs
+ * Unidade padrão de cada biomarcador, usada quando o laudo não imprime uma.
+ *
+ * Derivada de `unit` em `biomarkers.ts`, que é a fonte única. Até out/2026
+ * era uma segunda tabela escrita à mão, e as duas divergiam: TSH era
+ * `µUI/mL` aqui e `uIU/mL` lá, ferro era `µg/dL` aqui e `mcg/dL` lá. Duas
+ * fontes para a mesma unidade é o que faz o `fhir-bio units` e o `fhir-bio
+ * range` responderem coisas diferentes para o mesmo código.
  */
 declare const BIOMARKER_DEFAULT_UNIT: Record<string, string>;
 /**
  * Convert unit to UCUM format
+ *
+ * Devolve a entrada intacta quando não conhece a unidade. Para montar um
+ * `Quantity` FHIR use `resolveUcum`, que diz "não sei" em vez de devolver
+ * uma grafia qualquer como se fosse UCUM.
  */
 declare function unitToUCUM(unit: string): string;
 /**
@@ -24,6 +43,20 @@ declare function unitToUCUM(unit: string): string;
  * @returns The default unit or empty string if not found
  */
 declare function getDefaultUnit(biomarkerCode: string): string;
+/**
+ * Diz se a string é sintaticamente UCUM: componentes ligados por `.` e `/`,
+ * com `/` inicial permitido (`/[HPF]`).
+ *
+ * É sintaxe, não semântica: `K/uL` passa porque `K` é kelvin, e nada aqui sabe
+ * que o laudo quis dizer milhares. É o que `resolveUcum` e `BIOMARKER_UNITS`
+ * resolvem antes de a string chegar aqui. O que este check pega é o resto:
+ * grafia em português, `µ` fora do ASCII, `IU` sem colchetes, `hr`.
+ *
+ * O `.` e o `/` só separam fora de chaves e colchetes: `mL/min/{1.73_m2}` tem
+ * um ponto dentro da anotação, e `[in_i]` poderia ter um operador dentro do
+ * átomo.
+ */
+declare function isUcumCode(code: string): boolean;
 /** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */
 interface BiomarkerUnitConfig {
     aliases: Record<string, string>;
@@ -56,5 +89,20 @@ interface ConversionResult {
  * @returns The converted value and target unit, or null if conversion is not possible.
  */
 declare function convertUnit(value: number, fromUnit: string, toUnit: string, biomarkerCode: string): ConversionResult | null;
+/**
+ * Código UCUM para a unidade que o laudo imprimiu, ou `undefined`.
+ *
+ * Ordem: a configuração do biomarcador em `BIOMARKER_UNITS` (que já sabe que
+ * `K/uL` de leucócito é `10*3/uL`), depois a tabela `UNIT_TO_UCUM`, e por
+ * último a própria string, se for UCUM sintaticamente válido. Fora disso é
+ * `undefined`, e o conversor deixa o `Quantity` só com `unit`: unidade que
+ * não se sabe traduzir não sai sob `http://unitsofmeasure.org`.
+ *
+ * Até out/2026 o conversor só consultava a tabela e devolvia a entrada
+ * intacta quando não achava, então `uIU/mL`, `K/uL` e `razão` saíam como
+ * código UCUM, e os 85 `canonicalUcum` de `BIOMARKER_UNITS` não eram lidos
+ * por ninguém fora de `units.ts`.
+ */
+declare function resolveUcum(unit: string, biomarkerCode?: string): string | undefined;
 
-export { BIOMARKER_DEFAULT_UNIT, BIOMARKER_UNITS, type BiomarkerUnitConfig, type ConversionResult, UNIT_TO_UCUM, convertUnit, getCanonicalUnit, getDefaultUnit, getSIUnit, unitToUCUM };
+export { BIOMARKER_DEFAULT_UNIT, BIOMARKER_UNITS, type BiomarkerUnitConfig, type ConversionResult, UNIT_TO_UCUM, convertUnit, getCanonicalUnit, getDefaultUnit, getSIUnit, isUcumCode, resolveUcum, unitToUCUM };

package/dist/units.d.ts

@@ -5,17 +5,36 @@
  * and defines canonical/SI unit configurations with aliases.
  */
 /**
- * Map units to UCUM (Unified Code for Units of Measure)
- * See: https://ucum.org/
+ * Grafia impressa → código UCUM (Unified Code for Units of Measure).
+ *
+ * É a segunda fonte de `resolveUcum`, atrás de `BIOMARKER_UNITS`, e a única
+ * para unidade que nenhum biomarcador configura. Cobre toda unidade declarada
+ * em `biomarkers.ts`: o teste `loinc-axes.test.ts` confere isso, porque uma
+ * unidade sem entrada aqui saía no FHIR como `code` sob o system do UCUM sem
+ * ser UCUM (`uIU/mL`, `K/uL`, `razão`).
+ *
+ * `[IU]` e `[iU]` são o mesmo átomo no UCUM, nas grafias sensível e
+ * insensível a caixa; esta tabela usa `[IU]` e `BIOMARKER_UNITS` usa `[iU]`.
+ *
+ * @see https://ucum.org/
  */
 declare const UNIT_TO_UCUM: Record<string, string>;
 /**
- * Default units for biomarkers when source data doesn't provide one
- * These are the most common units used in Brazilian labs
+ * Unidade padrão de cada biomarcador, usada quando o laudo não imprime uma.
+ *
+ * Derivada de `unit` em `biomarkers.ts`, que é a fonte única. Até out/2026
+ * era uma segunda tabela escrita à mão, e as duas divergiam: TSH era
+ * `µUI/mL` aqui e `uIU/mL` lá, ferro era `µg/dL` aqui e `mcg/dL` lá. Duas
+ * fontes para a mesma unidade é o que faz o `fhir-bio units` e o `fhir-bio
+ * range` responderem coisas diferentes para o mesmo código.
  */
 declare const BIOMARKER_DEFAULT_UNIT: Record<string, string>;
 /**
  * Convert unit to UCUM format
+ *
+ * Devolve a entrada intacta quando não conhece a unidade. Para montar um
+ * `Quantity` FHIR use `resolveUcum`, que diz "não sei" em vez de devolver
+ * uma grafia qualquer como se fosse UCUM.
  */
 declare function unitToUCUM(unit: string): string;
 /**
@@ -24,6 +43,20 @@ declare function unitToUCUM(unit: string): string;
  * @returns The default unit or empty string if not found
  */
 declare function getDefaultUnit(biomarkerCode: string): string;
+/**
+ * Diz se a string é sintaticamente UCUM: componentes ligados por `.` e `/`,
+ * com `/` inicial permitido (`/[HPF]`).
+ *
+ * É sintaxe, não semântica: `K/uL` passa porque `K` é kelvin, e nada aqui sabe
+ * que o laudo quis dizer milhares. É o que `resolveUcum` e `BIOMARKER_UNITS`
+ * resolvem antes de a string chegar aqui. O que este check pega é o resto:
+ * grafia em português, `µ` fora do ASCII, `IU` sem colchetes, `hr`.
+ *
+ * O `.` e o `/` só separam fora de chaves e colchetes: `mL/min/{1.73_m2}` tem
+ * um ponto dentro da anotação, e `[in_i]` poderia ter um operador dentro do
+ * átomo.
+ */
+declare function isUcumCode(code: string): boolean;
 /** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */
 interface BiomarkerUnitConfig {
     aliases: Record<string, string>;
@@ -56,5 +89,20 @@ interface ConversionResult {
  * @returns The converted value and target unit, or null if conversion is not possible.
  */
 declare function convertUnit(value: number, fromUnit: string, toUnit: string, biomarkerCode: string): ConversionResult | null;
+/**
+ * Código UCUM para a unidade que o laudo imprimiu, ou `undefined`.
+ *
+ * Ordem: a configuração do biomarcador em `BIOMARKER_UNITS` (que já sabe que
+ * `K/uL` de leucócito é `10*3/uL`), depois a tabela `UNIT_TO_UCUM`, e por
+ * último a própria string, se for UCUM sintaticamente válido. Fora disso é
+ * `undefined`, e o conversor deixa o `Quantity` só com `unit`: unidade que
+ * não se sabe traduzir não sai sob `http://unitsofmeasure.org`.
+ *
+ * Até out/2026 o conversor só consultava a tabela e devolvia a entrada
+ * intacta quando não achava, então `uIU/mL`, `K/uL` e `razão` saíam como
+ * código UCUM, e os 85 `canonicalUcum` de `BIOMARKER_UNITS` não eram lidos
+ * por ninguém fora de `units.ts`.
+ */
+declare function resolveUcum(unit: string, biomarkerCode?: string): string | undefined;
 
-export { BIOMARKER_DEFAULT_UNIT, BIOMARKER_UNITS, type BiomarkerUnitConfig, type ConversionResult, UNIT_TO_UCUM, convertUnit, getCanonicalUnit, getDefaultUnit, getSIUnit, unitToUCUM };
+export { BIOMARKER_DEFAULT_UNIT, BIOMARKER_UNITS, type BiomarkerUnitConfig, type ConversionResult, UNIT_TO_UCUM, convertUnit, getCanonicalUnit, getDefaultUnit, getSIUnit, isUcumCode, resolveUcum, unitToUCUM };

package/dist/units.js

@@ -6,8 +6,11 @@ import {
   getCanonicalUnit,
   getDefaultUnit,
   getSIUnit,
+  isUcumCode,
+  resolveUcum,
   unitToUCUM
-} from "./chunk-3XIMPALK.js";
+} from "./chunk-Q3H5C6UR.js";
+import "./chunk-4FKZG5GZ.js";
 export {
   BIOMARKER_DEFAULT_UNIT,
   BIOMARKER_UNITS,
@@ -16,6 +19,8 @@ export {
   getCanonicalUnit,
   getDefaultUnit,
   getSIUnit,
+  isUcumCode,
+  resolveUcum,
   unitToUCUM
 };
 //# sourceMappingURL=units.js.map

package/dist/validators.cjs

@@ -2,10 +2,12 @@
 
 
 
-var _chunk3ILBFLVQcjs = require('./chunk-3ILBFLVQ.cjs');
+var _chunkOAFAERDYcjs = require('./chunk-OAFAERDY.cjs');
+require('./chunk-5RC7C7HJ.cjs');
+require('./chunk-T75NZM56.cjs');
 
 
 
 
-exports.validateFHIRDiagnosticReport = _chunk3ILBFLVQcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunk3ILBFLVQcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunk3ILBFLVQcjs.validateFHIRObservation;
+exports.validateFHIRDiagnosticReport = _chunkOAFAERDYcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunkOAFAERDYcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunkOAFAERDYcjs.validateFHIRObservation;
 //# sourceMappingURL=validators.cjs.map

package/dist/validators.cjs.map

@@ -1 +1 @@
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package/dist/validators.d.cts

@@ -1,4 +1,4 @@
-import { k as FHIRDiagnosticReport, a as FHIRObservation } from './fhir-types-B1KQmlRb.cjs';
+import { k as FHIRDiagnosticReport, a as FHIRObservation } from './fhir-types-Cn5WFbOI.cjs';
 import { ImportError } from './importer.cjs';
 
 /**

package/dist/validators.d.ts

@@ -1,4 +1,4 @@
-import { k as FHIRDiagnosticReport, a as FHIRObservation } from './fhir-types-B1KQmlRb.js';
+import { k as FHIRDiagnosticReport, a as FHIRObservation } from './fhir-types-Cn5WFbOI.js';
 import { ImportError } from './importer.js';
 
 /**

package/dist/validators.js

@@ -2,7 +2,9 @@ import {
   validateFHIRDiagnosticReport,
   validateFHIRImportBundle,
   validateFHIRObservation
-} from "./chunk-N3ZCOLG2.js";
+} from "./chunk-E6MXDQXW.js";
+import "./chunk-Q3H5C6UR.js";
+import "./chunk-4FKZG5GZ.js";
 export {
   validateFHIRDiagnosticReport,
   validateFHIRImportBundle,

package/package.json

@@ -1,6 +1,6 @@
 {
   "name": "@precisa-saude/fhir",
-  "version": "0.32.0",
+  "version": "0.34.0",
   "description": "Tipos FHIR R4, definições de biomarcadores, faixas de referência e conversores para o ecossistema de saúde brasileiro",
   "keywords": [
     "fhir",

package/dist/chunk-3ILBFLVQ.cjs.map

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(!observation.resourceType || observation.resourceType !== 'Observation') {\n    errors.push('Invalid resourceType');\n  }\n\n  if (!observation.status) {\n    errors.push('Missing status');\n  }\n\n  if (!observation.code || !observation.code.coding || observation.code.coding.length === 0) {\n    errors.push('Missing or invalid code');\n  }\n\n  if (!observation.subject || !observation.subject.reference) {\n    errors.push('Missing subject reference');\n  }\n\n  if (!observation.valueQuantity && !observation.valueString) {\n    errors.push('Missing value (valueQuantity or valueString)');\n  }\n\n  return errors;\n}\n\n/**\n * Validate that the input is a structurally valid FHIR Bundle\n */\nexport function validateFHIRImportBundle(data: unknown): ImportError[] {\n  const errors: ImportError[] = [];\n\n  if (!data || typeof data !== 'object') {\n    errors.push({ details: 'Input must be a JSON object', field: 'root' });\n    return errors;\n  }\n\n  const bundle = data as Record<string, unknown>;\n\n  if (bundle.resourceType !== 'Bundle') {\n    errors.push({\n      details: `Expected resourceType \"Bundle\", got \"${String(bundle.resourceType)}\"`,\n      field: 'resourceType',\n    });\n  }\n\n  if (!Array.isArray(bundle.entry)) {\n    errors.push({ details: 'Bundle must contain an \"entry\" array', field: 'entry' });\n  } else if (bundle.entry.length === 0) {\n    errors.push({ details: 'Bundle entry array is empty', field: 'entry' });\n  }\n\n  return errors;\n}\n"]}

package/dist/chunk-3XIMPALK.js.map

@@ -1 +0,0 @@
-{"version":3,"sources":["../src/units.ts"],"sourcesContent":["/**\n * Unit Mappings and Biomarker Unit Definitions\n *\n * Maps units to UCUM format, provides default units for biomarkers,\n * and defines canonical/SI unit configurations with aliases.\n */\n\n// ─── UCUM Mappings ───────────────────────────────────────────────────────────\n\n/**\n * Map units to UCUM (Unified Code for Units of Measure)\n * See: https://ucum.org/\n */\nexport const UNIT_TO_UCUM: Record<string, string> = {\n  // Dimensionless / special measurements\n  '[pH]': '[pH]',\n  '{ratio}': '{ratio}',\n  '{specific gravity}': '{specific gravity}',\n\n  '/µL': '/uL',\n  // Percentage\n  '%': '%',\n  // Count units\n  '10³/µL': '10*3/uL',\n  '10⁶/µL': '10*6/uL',\n  // Volume\n  fL: 'fL',\n  g: 'g',\n\n  // Mass concentration\n  'g/dL': 'g/dL',\n  L: 'L',\n  // Molar concentration\n  'mEq/L': 'meq/L',\n\n  mg: 'mg',\n  'mg/dL': 'mg/dL',\n  mL: 'mL',\n  'mmol/L': 'mmol/L',\n  'mUI/mL': 'm[IU]/mL',\n\n  ng: 'ng',\n\n  'ng/dL': 'ng/dL',\n  'ng/mL': 'ng/mL',\n  'nmol/L': 'nmol/L',\n  // Mass\n  pg: 'pg',\n\n  'pg/mL': 'pg/mL',\n  pH: '[pH]',\n  // Enzyme activity\n  'U/L': 'U/L',\n  // Special units\n  'U/mL': 'U/mL',\n  'UI/L': '[IU]/L',\n\n  'UI/mL': '[IU]/mL',\n\n  µg: 'ug',\n  'µg/dL': 'ug/dL',\n  'µmol/L': 'umol/L',\n  'µUI/mL': 'u[IU]/mL',\n};\n\n/**\n * Default units for biomarkers when source data doesn't provide one\n * These are the most common units used in Brazilian labs\n */\nexport const BIOMARKER_DEFAULT_UNIT: Record<string, string> = {\n  // Proteins\n  Albumin: 'g/dL',\n  AlkalinePhosphatase: 'U/L',\n  // Liver\n  ALT: 'U/L',\n  AST: 'U/L',\n\n  Calcium: 'mg/dL',\n  Chloride: 'mEq/L',\n  // Lipids\n  Cholesterol: 'mg/dL',\n  // Kidney\n  Creatinine: 'mg/dL',\n  eAG: 'mg/dL',\n  Ferritin: 'ng/mL',\n\n  FolicAcid: 'ng/mL',\n  GGT: 'U/L',\n  // Glucose/Diabetes\n  Glucose: 'mg/dL',\n\n  HbA1c: '%',\n  Hct: '%',\n\n  HDL: 'mg/dL',\n  // Hematology\n  Hgb: 'g/dL',\n  Insulin: 'µUI/mL',\n\n  // Iron studies\n  Iron: 'µg/dL',\n  LDL: 'mg/dL',\n  Magnesium: 'mg/dL',\n  NonHDL_Cholesterol: 'mg/dL',\n\n  // Urinalysis - dimensionless\n  pH_Urine: '[pH]',\n  Potassium: 'mEq/L',\n  RDW: '%',\n  // Electrolytes\n  Sodium: 'mEq/L',\n  SpecificGravity_Urine: '{specific gravity}',\n\n  T3Free: 'pg/mL',\n  T4Free: 'ng/dL',\n  TIBC: 'µg/dL',\n  TotalProtein: 'g/dL',\n\n  TransferrinSaturation: '%',\n  Triglycerides: 'mg/dL',\n  // Thyroid\n  TSH: 'µUI/mL',\n\n  Urea: 'mg/dL',\n  UricAcid: 'mg/dL',\n\n  // Vitamins\n  VitaminB12: 'pg/mL',\n  VitaminD: 'ng/mL',\n  VLDL: 'mg/dL',\n};\n\n/**\n * Convert unit to UCUM format\n */\nexport function unitToUCUM(unit: string): string {\n  return UNIT_TO_UCUM[unit] || unit;\n}\n\n/**\n * Get default unit for a biomarker code\n * @param biomarkerCode - The biomarker code (e.g., \"Glucose\", \"HbA1c\")\n * @returns The default unit or empty string if not found\n */\nexport function getDefaultUnit(biomarkerCode: string): string {\n  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || '';\n}\n\n// ─── Biomarker Unit Configurations ───────────────────────────────────────────\n\n/** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */\n\nexport interface BiomarkerUnitConfig {\n  aliases: Record<string, string>;\n  canonicalUcum: string;\n  canonicalUnit: string;\n  molecularWeight?: number;\n  siUcum: string;\n  siUnit: string;\n}\n\nconst CBC_DIFF_ALIASES: Record<string, string> = {\n  '/ul': '/uL',\n  '/µl': '/uL',\n  '10*3/ul': 'K/uL',\n  'cells/ul': '/uL',\n  'cells/µl': '/uL',\n  'k/ul': 'K/uL',\n  'x10e3/ul': 'K/uL',\n};\nconst CBC_DIFF: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '10*3/uL',\n  canonicalUnit: 'K/uL',\n  siUcum: '10*3/uL',\n  siUnit: 'K/uL',\n};\nconst DEXA_KG_ALIASES: Record<string, string> = {\n  kg: 'kg',\n  lb: '[lb_av]',\n  lbs: '[lb_av]',\n};\nconst DEXA_KG: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'kg',\n  canonicalUnit: 'kg',\n  siUcum: 'kg',\n  siUnit: 'kg',\n};\n\n/**\n * Urine sediment units — Brazilian automated analyzers (Sysmex UF-series)\n * report in /mL while manual microscopy uses /HPF. Canonical unit is /HPF.\n */\nconst URINE_SEDIMENT_ALIASES: Record<string, string> = {\n  '/hpf': '/HPF',\n  '/ml': '/mL',\n};\nconst URINE_SEDIMENT: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '/[HPF]',\n  canonicalUnit: '/HPF',\n  siUcum: '/[HPF]',\n  siUnit: '/HPF',\n};\n\n/** Percentage biomarkers — canonical and SI both use %. */\nconst PERCENTAGE_ALIASES: Record<string, string> = { '%': '%', pct: '%', percent: '%' };\nconst PERCENTAGE: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '%',\n  canonicalUnit: '%',\n  siUcum: '%',\n  siUnit: '%',\n};\n\n/** Enzyme activity — canonical and SI both use U/L. */\nconst ENZYME_ALIASES: Record<string, string> = { 'iu/l': 'U/L', 'u/l': 'U/L' };\nconst ENZYME: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'U/L',\n  canonicalUnit: 'U/L',\n  siUcum: 'U/L',\n  siUnit: 'U/L',\n};\n\n/** Monovalent electrolytes — mEq/L ↔ mmol/L (1:1). */\nconst ELECTROLYTE_MONO_ALIASES: Record<string, string> = { 'meq/l': 'mEq/L', 'mmol/l': 'mmol/L' };\nconst ELECTROLYTE_MONO: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'meq/L',\n  canonicalUnit: 'mEq/L',\n  siUcum: 'mmol/L',\n  siUnit: 'mmol/L',\n};\n\n/** CAC scores — Agatston Units (AU), dimensionless. */\nconst CAC_ALIASES: Record<string, string> = { au: 'AU' };\nconst CAC: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '{score}',\n  canonicalUnit: 'AU',\n  siUcum: '{score}',\n  siUnit: 'AU',\n};\n\n/** nmol/L biomarkers — same unit for canonical and SI. */\nconst NMOL_L_ALIASES: Record<string, string> = { 'nmol/l': 'nmol/L' };\nconst NMOL_L: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'nmol/L',\n  canonicalUnit: 'nmol/L',\n  siUcum: 'nmol/L',\n  siUnit: 'nmol/L',\n};\n\nexport const BIOMARKER_UNITS: Record<string, BiomarkerUnitConfig> = {\n  AFP: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Albumin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  AlkalinePhosphatase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  ALT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AMH: {\n    aliases: { 'ng/ml': 'ng/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 12_500,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Amylase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  AntiThyroglobulin: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AntiTPO: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  AoA1: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AorticValveCalcium: { aliases: CAC_ALIASES, ...CAC },\n  ApoB: {\n    aliases: { 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'mg/dL',\n    siUnit: 'mg/dL',\n  },\n  AST: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Basophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  BilirubinDirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinIndirect: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BilirubinTotal: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 584.66,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  BMI: {\n    aliases: { 'kg/m2': 'kg/m²', 'kg/m²': 'kg/m²' },\n    canonicalUcum: 'kg/m2',\n    canonicalUnit: 'kg/m²',\n    siUcum: 'kg/m2',\n    siUnit: 'kg/m²',\n  },\n  BNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  CA125: {\n    aliases: { 'u/ml': 'U/mL' },\n    canonicalUcum: 'U/mL',\n    canonicalUnit: 'U/mL',\n    siUcum: 'U/mL',\n    siUnit: 'U/mL',\n  },\n  CAC_LAD: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LCX: { aliases: CAC_ALIASES, ...CAC },\n  CAC_LMA: { aliases: CAC_ALIASES, ...CAC },\n  CAC_RCA: { aliases: CAC_ALIASES, ...CAC },\n  Calcium: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 40.08,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CEA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Chloride: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  CK: { aliases: ENZYME_ALIASES, ...ENZYME },\n  CO2: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Cortisol: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 362.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Creatinine: {\n    aliases: { 'mg/dl': 'mg/dL', 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 113.12,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  CRP: {\n    aliases: { 'mg/dl': 'mg/dL', 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  DHEAS: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 368.49,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  DHT: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 290.44,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  eGFR: {\n    aliases: {\n      'ml/min/1,73 m2': 'mL/min/1.73m²',\n      'ml/min/1.73m2': 'mL/min/1.73m²',\n      'ml/min/1.73m²': 'mL/min/1.73m²',\n    },\n    canonicalUcum: 'mL/min/{1.73_m2}',\n    canonicalUnit: 'mL/min/1.73m²',\n    siUcum: 'mL/min/{1.73_m2}',\n    siUnit: 'mL/min/1.73m²',\n  },\n  Eosinophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  EPADPADHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  ESR: {\n    aliases: { 'mm/h': 'mm/h', 'mm/hr': 'mm/h' },\n    canonicalUcum: 'mm/h',\n    canonicalUnit: 'mm/h',\n    siUcum: 'mm/h',\n    siUnit: 'mm/h',\n  },\n  Estradiol: {\n    aliases: { 'ng/dl': 'ng/dL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 272.38,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Ferritin: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  Folate: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 441.4,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  FSH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  GGT: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Globulin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Glucose: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 180.156,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HbA1c: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Hct: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  HDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HDL_Large: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Hgb: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Homocysteine: {\n    aliases: { 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'umol/L',\n    canonicalUnit: 'µmol/L',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  // Imunoglobulinas: canônica em mg/dL, a unidade da faixa de referência\n  // (Tietz) e a que laboratórios brasileiros e americanos imprimem. g/L fica\n  // como unidade SI; a conversão é exata (g/L × 100 = mg/dL, em FIXED_FACTORS).\n  IgA: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  IgG: {\n    aliases: { 'g/l': 'g/L', 'mg/dl': 'mg/dL' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  INR: {\n    aliases: { '{ratio}': '{ratio}' },\n    canonicalUcum: '{ratio}',\n    canonicalUnit: '{ratio}',\n    siUcum: '{ratio}',\n    siUnit: '{ratio}',\n  },\n  Insulin: {\n    aliases: {\n      'mu/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Iron: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  LDL_Medium: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_ParticleNumber: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  LDL_Peak_Size: {\n    aliases: { å: 'Ao', angstrom: 'Ao', ao: 'Ao', nm: 'nm' },\n    canonicalUcum: 'Ao',\n    canonicalUnit: 'Angstrom',\n    siUcum: 'nm',\n    siUnit: 'nm',\n  },\n  LDL_Small: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Lead: {\n    aliases: { 'mcg/dl': 'µg/dL', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 207.2,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Leptin: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  LH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Lipase: { aliases: ENZYME_ALIASES, ...ENZYME },\n  Lipoprotein_a: {\n    aliases: { 'mg/dl': 'mg/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'nmol/L',\n    canonicalUnit: 'nmol/L',\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Lymphocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MCH: {\n    aliases: { pg: 'pg' },\n    canonicalUcum: 'pg',\n    canonicalUnit: 'pg',\n    siUcum: 'pg',\n    siUnit: 'pg',\n  },\n  MCHC: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  MCV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Mercury: {\n    aliases: { 'mcg/l': 'µg/L', 'nmol/l': 'nmol/L', 'ug/l': 'µg/L', 'µg/l': 'µg/L' },\n    canonicalUcum: 'ug/L',\n    canonicalUnit: 'µg/L',\n    molecularWeight: 200.59,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Microalbumin_Urine: {\n    aliases: { 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  MMA: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Monocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MPV: {\n    aliases: { fl: 'fL' },\n    canonicalUcum: 'fL',\n    canonicalUnit: 'fL',\n    siUcum: 'fL',\n    siUnit: 'fL',\n  },\n  Myeloperoxidase: {\n    aliases: { 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pmol/L',\n    canonicalUnit: 'pmol/L',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Neutrophils: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  // MW 386.65 = colesterol livre. Frações lipoproteicas são heterogêneas,\n  // mas a conversão mg/dL→mmol/L usa MW do colesterol por convenção clínica.\n  NonHDL_Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  NTproBNP: {\n    aliases: { 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pg/mL',\n    siUnit: 'pg/mL',\n  },\n  Omega3_DHA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_DPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_EPA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega3_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_AA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_LA: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Omega6_Total: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Potassium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  Progesterone: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 314.46,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Prolactin: {\n    aliases: {\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  ProthrombinTime: {\n    aliases: { s: 's', sec: 's' },\n    canonicalUcum: 's',\n    canonicalUnit: 's',\n    siUcum: 's',\n    siUnit: 's',\n  },\n  PSA: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  PSA_Free: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  RBC: {\n    aliases: {\n      '/ul': '/uL',\n      '/µl': '/uL',\n      '10*6/ul': 'M/uL',\n      'cells/ul': '/uL',\n      'm/ul': 'M/uL',\n      'milhões/mm3': 'M/uL',\n      'milhões/mm³': 'M/uL',\n      'x10e6/ul': 'M/uL',\n    },\n    canonicalUcum: '10*6/uL',\n    canonicalUnit: 'M/uL',\n    siUcum: '10*6/uL',\n    siUnit: 'M/uL',\n  },\n  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  RDW: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  Reticulocytes: { aliases: PERCENTAGE_ALIASES, ...PERCENTAGE },\n  RheumatoidFactor: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  SHBG: { aliases: NMOL_L_ALIASES, ...NMOL_L },\n  Sodium: { aliases: ELECTROLYTE_MONO_ALIASES, ...ELECTROLYTE_MONO },\n  T3Free: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 650.98,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T4Free: {\n    aliases: { 'ng/dl': 'ng/dL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 776.87,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  T4Total: {\n    aliases: { 'mcg/dl': 'µg/dL', 'nmol/l': 'nmol/L', 'ug/dl': 'µg/dL', 'µg/dl': 'µg/dL' },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'µg/dL',\n    molecularWeight: 776.87,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Testosterone: {\n    aliases: { 'ng/dl': 'ng/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/dL',\n    canonicalUnit: 'ng/dL',\n    molecularWeight: 288.42,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  TestosteroneFree: {\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pmol/L' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 288.42,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  TIBC: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  TotalProtein: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Triglycerides: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 885.4,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  TroponinI: {\n    aliases: { 'ng/ml': 'ng/mL' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ng/mL',\n    siUnit: 'ng/mL',\n  },\n  // Troponina T: canônica em ng/L (hs-cTnT). O ensaio convencional imprime em\n  // ng/mL, que é a mesma grandeza que µg/L; converte por fator exato\n  // (ng/mL × 1000 = ng/L, em FIXED_FACTORS). pg/mL é a mesma unidade que ng/L\n  // e entra como alias, como em VitaminB12.\n  TroponinT: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/l': 'ng/L',\n      'ng/ml': 'ng/mL',\n      'pg/ml': 'ng/L',\n      'ug/l': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/L',\n    canonicalUnit: 'ng/L',\n    siUcum: 'ng/L',\n    siUnit: 'ng/L',\n  },\n  TSH: {\n    aliases: {\n      'miu/l': 'uIU/mL',\n      'mui/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'mIU/L',\n    siUnit: 'mIU/L',\n  },\n  Urea: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 60.06,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  UricAcid: {\n    aliases: { 'mg/dl': 'mg/dL', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 168.11,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  VATVolume: {\n    aliases: { cm3: 'cm3', 'cm³': 'cm3', in3: '[in_i]3', 'in³': '[in_i]3' },\n    canonicalUcum: 'cm3',\n    canonicalUnit: 'cm³',\n    siUcum: 'cm3',\n    siUnit: 'cm³',\n  },\n  VitaminB12: {\n    aliases: { 'ng/l': 'pg/mL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  VitaminD: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 384.64,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  VLDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n};\n\n/**\n * Get the canonical unit for a biomarker code.\n */\nexport function getCanonicalUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;\n}\n\n/**\n * Get the SI unit for a biomarker code.\n */\nexport function getSIUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.siUnit ?? null;\n}\n\n// ─── Unit Conversion ────────────────────────────────────────────────────────────\n\n/**\n * Normalize a unit string to its canonical display form for a given biomarker.\n * Returns the input unchanged if no alias is found.\n */\nfunction normalizeUnit(unit: string, config: BiomarkerUnitConfig): string {\n  return config.aliases[unit.toLowerCase()] ?? config.aliases[unit] ?? unit;\n}\n\n/**\n * Conversion factor tables for unit pairs that don't require molecular weight.\n * Key format: \"fromUnit -> toUnit\" (using canonical display forms).\n * Both directions must be listed explicitly — there is no auto-inversion.\n */\nconst FIXED_FACTORS: Record<string, number> = {\n  'g/dL -> g/L': 10,\n  'g/L -> g/dL': 0.1,\n  'g/L -> mg/dL': 100,\n  'mEq/L -> mmol/L': 1,\n  'mg/dL -> g/L': 0.01,\n  'mmol/L -> mEq/L': 1,\n  'ng/dL -> pg/mL': 10,\n  'ng/L -> ng/mL': 0.001,\n  'ng/mL -> ng/L': 1000,\n  'ng/mL -> µg/L': 1,\n  'pg/mL -> ng/dL': 0.1,\n  'µg/L -> ng/mL': 1,\n};\n\n/**\n * MW-based conversion definitions.\n * Each entry maps a (fromUnit, toUnit) pair to the formula:\n *   result = value × numerator / (MW × denominator)\n *\n * Common patterns:\n *   mg/dL  → mmol/L:  value × 10   / MW\n *   mg/dL  → µmol/L:  value × 10000 / MW  (or equivalently × 10 / MW × 1000)\n *   ng/mL  → nmol/L:  value × 1000 / MW\n *   pg/mL  → pmol/L:  value × 1000 / MW\n *   ng/dL  → nmol/L:  value × 10   / MW\n */\n/**\n * MW conversion entries. Each direction is explicit to avoid fragile inversion logic.\n * Formula: result = value × scale / MW  (when divideByMW is true)\n *          result = value × MW / scale  (when divideByMW is false)\n */\ninterface MWConversion {\n  divideByMW: boolean;\n  scale: number;\n}\n\nconst MW_CONVERSIONS: Record<string, MWConversion> = {\n  'mg/dL -> mmol/L': { divideByMW: true, scale: 10 },\n  'mg/dL -> µmol/L': { divideByMW: true, scale: 10_000 },\n  'mmol/L -> mg/dL': { divideByMW: false, scale: 10 },\n  'ng/dL -> nmol/L': { divideByMW: true, scale: 10 },\n  'ng/dL -> pmol/L': { divideByMW: true, scale: 10_000 },\n  'ng/mL -> nmol/L': { divideByMW: true, scale: 1000 },\n  'ng/mL -> pmol/L': { divideByMW: true, scale: 1_000_000 },\n  'nmol/L -> ng/dL': { divideByMW: false, scale: 10 },\n  'nmol/L -> ng/mL': { divideByMW: false, scale: 1000 },\n  'nmol/L -> µg/dL': { divideByMW: false, scale: 10_000 },\n  'nmol/L -> µg/L': { divideByMW: false, scale: 1000 },\n  'pg/mL -> pmol/L': { divideByMW: true, scale: 1000 },\n  'pmol/L -> ng/dL': { divideByMW: false, scale: 10_000 },\n  'pmol/L -> ng/mL': { divideByMW: false, scale: 1_000_000 },\n  'pmol/L -> pg/mL': { divideByMW: false, scale: 1000 },\n  'µg/dL -> nmol/L': { divideByMW: true, scale: 10_000 },\n  'µg/dL -> µmol/L': { divideByMW: true, scale: 10 },\n  'µg/L -> nmol/L': { divideByMW: true, scale: 1000 },\n  'µmol/L -> mg/dL': { divideByMW: false, scale: 10_000 },\n  'µmol/L -> µg/dL': { divideByMW: false, scale: 10 },\n};\n\nexport interface ConversionResult {\n  unit: string;\n  value: number;\n}\n\n/**\n * Convert a biomarker value between units.\n *\n * Supports:\n * - Fixed-factor conversions (e.g. ng/dL ↔ pg/mL, g/dL ↔ g/L)\n * - Molecular-weight-based conversions (e.g. mg/dL ↔ mmol/L, pg/mL ↔ pmol/L)\n *\n * @returns The converted value and target unit, or null if conversion is not possible.\n */\nexport function convertUnit(\n  value: number,\n  fromUnit: string,\n  toUnit: string,\n  biomarkerCode: string,\n): ConversionResult | null {\n  const config = BIOMARKER_UNITS[biomarkerCode];\n  if (!config) return null;\n\n  const normFrom = normalizeUnit(fromUnit, config);\n  const normTo = normalizeUnit(toUnit, config);\n\n  if (normFrom === normTo) {\n    return { unit: normTo, value };\n  }\n\n  const key = `${normFrom} -> ${normTo}`;\n\n  const fixedFactor = FIXED_FACTORS[key];\n  if (fixedFactor !== undefined) {\n    return { unit: normTo, value: value * fixedFactor };\n  }\n\n  const mwConv = MW_CONVERSIONS[key];\n  if (mwConv && config.molecularWeight) {\n    const result = mwConv.divideByMW\n      ? (value * mwConv.scale) / config.molecularWeight\n      : (value * config.molecularWeight) / mwConv.scale;\n    return { unit: normTo, value: result };\n  }\n\n  return 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package/dist/chunk-4Y43MQQK.js.map

@@ -1 +0,0 @@
-{"version":3,"sources":["../src/importer.ts"],"sourcesContent":["/**\n * FHIR Importer\n *\n * Parses FHIR R4 Bundles and extracts Observation resources with known LOINC codes,\n * mapping them to internal biomarker codes for storage as lab results.\n */\n\nimport {\n  codeToLoinc,\n  getDefinitionByCode,\n  isValidCode,\n  loincToCode,\n  normalizeCode,\n} from './biomarkers';\nimport { BIOMARKER_CODE_SYSTEM, LOINC_SYSTEM } from './code-systems';\nimport type { FHIRBundle, FHIRObservation } from './fhir-types';\nimport { validateFHIRImportBundle } from './validators';\n\nexport interface ImportedObservation {\n  biomarkerCode: string;\n  biomarkerName: string;\n  collectionDate: string;\n  flag: 'H' | 'L' | '';\n  isQualitative: boolean;\n  /** Ausente nos biomarcadores sem LOINC publicado, como composição corporal. */\n  loincCode?: string;\n  referenceMax?: number;\n  referenceMin?: number;\n  unit: string;\n  value: number | string;\n}\n\nexport interface SkippedEntry {\n  index: number;\n  loincCode?: string;\n  reason: string;\n  resourceType?: string;\n}\n\nexport interface ImportError {\n  details: string;\n  field: string;\n}\n\nexport interface FHIRImportResult {\n  errors: ImportError[];\n  imported: ImportedObservation[];\n  skipped: SkippedEntry[];\n  totalProcessed: number;\n}\n\n/**\n * Limites de importação.\n *\n * Uma Observation exportada ocupa cerca de 1,25KB em JSON compacto e 2,75KB\n * quando o arquivo vem indentado, medido sobre um histórico real de 998\n * Observations em 61 laudos. Nesse tamanho, 5000 Observations dão 6,0MB\n * compactos ou 13,1MB indentados, e por isso o teto de arquivo é 15MB: cobre\n * as duas formas com folga.\n *\n * Na densidade desse mesmo histórico (16 Observations por laudo), 5000\n * equivalem a cerca de 300 laudos.\n */\nconst MAX_OBSERVATIONS = 5000;\nconst MAX_FILE_SIZE = 15 * 1024 * 1024; // 15MB\n\n/**\n * Resolve o código interno do biomarcador a partir do `code.coding`.\n *\n * LOINC primeiro, que é o vocabulário que arquivos de terceiros usam. Quando\n * não resolve, cai para o coding de códigos internos, presente nos arquivos\n * exportados pela própria plataforma.\n *\n * O fallback cobre dois casos: biomarcadores sem LOINC publicado (composição\n * corporal, densidade óssea, escore de cálcio) e arquivos antigos, exportados\n * quando esses biomarcadores saíam com o placeholder `99999-9`, que não\n * resolve para nada.\n */\nfunction resolveBiomarkerCode(observation: FHIRObservation): {\n  internalCode?: string;\n  loincCode?: string;\n  reason: string;\n} {\n  const coding = observation.code?.coding ?? [];\n  const loincCode = coding.find((c) => c.system === LOINC_SYSTEM)?.code;\n  const declaredCode = coding.find((c) => c.system === BIOMARKER_CODE_SYSTEM)?.code;\n\n  const seenCodes = [\n    ...(loincCode ? [`LOINC ${loincCode}`] : []),\n    ...(declaredCode ? [`biomarker code ${declaredCode}`] : []),\n  ];\n\n  // Três motivos distintos de descarte, que antes se confundiam num só. 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