@precisa-saude/fhir 0.31.5 → 0.32.0

package/dist/biomarkers.cjs

@@ -30,7 +30,7 @@
 
 
 
-var _chunkQOXTLPQ2cjs = require('./chunk-QOXTLPQ2.cjs');
+var _chunkMKH4Q735cjs = require('./chunk-MKH4Q735.cjs');
 
 
 
@@ -63,5 +63,5 @@ var _chunkQOXTLPQ2cjs = require('./chunk-QOXTLPQ2.cjs');
 
 
 
-exports.BIOMARKER_DEFINITIONS = _chunkQOXTLPQ2cjs.BIOMARKER_DEFINITIONS; exports.CAC_INDICATOR_CODES = _chunkQOXTLPQ2cjs.CAC_INDICATOR_CODES; exports.DEXA_CATEGORIES = _chunkQOXTLPQ2cjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkQOXTLPQ2cjs.DEXA_INDICATOR_CODES; exports.codeToLoinc = _chunkQOXTLPQ2cjs.codeToLoinc; exports.filterVisibleBiomarkers = _chunkQOXTLPQ2cjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkQOXTLPQ2cjs.findCodeByName; exports.generateCacFullReference = _chunkQOXTLPQ2cjs.generateCacFullReference; exports.generateDexaFullReference = _chunkQOXTLPQ2cjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkQOXTLPQ2cjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkQOXTLPQ2cjs.generateLLMReference; exports.getAllCodes = _chunkQOXTLPQ2cjs.getAllCodes; exports.getAllDefinitions = _chunkQOXTLPQ2cjs.getAllDefinitions; exports.getAllLoincCodes = _chunkQOXTLPQ2cjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkQOXTLPQ2cjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkQOXTLPQ2cjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkQOXTLPQ2cjs.getBiomarkersForCategories; exports.getDefinitionByCode = _chunkQOXTLPQ2cjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkQOXTLPQ2cjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkQOXTLPQ2cjs.getDefinitionsBySex; exports.getSexForCode = _chunkQOXTLPQ2cjs.getSexForCode; exports.getVisibleDefinitions = _chunkQOXTLPQ2cjs.getVisibleDefinitions; exports.isBiomarkerVisible = _chunkQOXTLPQ2cjs.isBiomarkerVisible; exports.isCacDocument = _chunkQOXTLPQ2cjs.isCacDocument; exports.isDexaDocument = _chunkQOXTLPQ2cjs.isDexaDocument; exports.isValidCode = _chunkQOXTLPQ2cjs.isValidCode; exports.isValidLoinc = _chunkQOXTLPQ2cjs.isValidLoinc; exports.loincToCode = _chunkQOXTLPQ2cjs.loincToCode; exports.normalizeCode = _chunkQOXTLPQ2cjs.normalizeCode; exports.toBiomarkerTests = _chunkQOXTLPQ2cjs.toBiomarkerTests; exports.validateLoincNameMatch = _chunkQOXTLPQ2cjs.validateLoincNameMatch;
+exports.BIOMARKER_DEFINITIONS = _chunkMKH4Q735cjs.BIOMARKER_DEFINITIONS; exports.CAC_INDICATOR_CODES = _chunkMKH4Q735cjs.CAC_INDICATOR_CODES; exports.DEXA_CATEGORIES = _chunkMKH4Q735cjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkMKH4Q735cjs.DEXA_INDICATOR_CODES; exports.codeToLoinc = _chunkMKH4Q735cjs.codeToLoinc; exports.filterVisibleBiomarkers = _chunkMKH4Q735cjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkMKH4Q735cjs.findCodeByName; exports.generateCacFullReference = _chunkMKH4Q735cjs.generateCacFullReference; exports.generateDexaFullReference = _chunkMKH4Q735cjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkMKH4Q735cjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkMKH4Q735cjs.generateLLMReference; exports.getAllCodes = _chunkMKH4Q735cjs.getAllCodes; exports.getAllDefinitions = _chunkMKH4Q735cjs.getAllDefinitions; exports.getAllLoincCodes = _chunkMKH4Q735cjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkMKH4Q735cjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkMKH4Q735cjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkMKH4Q735cjs.getBiomarkersForCategories; exports.getDefinitionByCode = _chunkMKH4Q735cjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkMKH4Q735cjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkMKH4Q735cjs.getDefinitionsBySex; exports.getSexForCode = _chunkMKH4Q735cjs.getSexForCode; exports.getVisibleDefinitions = _chunkMKH4Q735cjs.getVisibleDefinitions; exports.isBiomarkerVisible = _chunkMKH4Q735cjs.isBiomarkerVisible; exports.isCacDocument = _chunkMKH4Q735cjs.isCacDocument; exports.isDexaDocument = _chunkMKH4Q735cjs.isDexaDocument; exports.isValidCode = _chunkMKH4Q735cjs.isValidCode; exports.isValidLoinc = _chunkMKH4Q735cjs.isValidLoinc; exports.loincToCode = _chunkMKH4Q735cjs.loincToCode; exports.normalizeCode = _chunkMKH4Q735cjs.normalizeCode; exports.toBiomarkerTests = _chunkMKH4Q735cjs.toBiomarkerTests; exports.validateLoincNameMatch = _chunkMKH4Q735cjs.validateLoincNameMatch;
 //# sourceMappingURL=biomarkers.cjs.map

package/dist/biomarkers.js

@@ -30,7 +30,7 @@ import {
   normalizeCode,
   toBiomarkerTests,
   validateLoincNameMatch
-} from "./chunk-PK5DQMPC.js";
+} from "./chunk-WDDW2WCY.js";
 export {
   BIOMARKER_DEFINITIONS,
   CAC_INDICATOR_CODES,

package/dist/{chunk-SDKLR3DT.cjs → chunk-44QMNDOI.cjs}

@@ -1,17 +1,17 @@
 "use strict";Object.defineProperty(exports, "__esModule", {value: true}); function _nullishCoalesce(lhs, rhsFn) { if (lhs != null) { return lhs; } else { return rhsFn(); } } function _optionalChain(ops) { let lastAccessLHS = undefined; let value = ops[0]; let i = 1; while (i < ops.length) { const op = ops[i]; const fn = ops[i + 1]; i += 2; if ((op === 'optionalAccess' || op === 'optionalCall') && value == null) { return undefined; } if (op === 'access' || op === 'optionalAccess') { lastAccessLHS = value; value = fn(value); } else if (op === 'call' || op === 'optionalCall') { value = fn((...args) => value.call(lastAccessLHS, ...args)); lastAccessLHS = undefined; } } return value; }
 
+var _chunk3ILBFLVQcjs = require('./chunk-3ILBFLVQ.cjs');
 
-var _chunkOR67NJDZcjs = require('./chunk-OR67NJDZ.cjs');
 
 
+var _chunkOR67NJDZcjs = require('./chunk-OR67NJDZ.cjs');
 
 
 
 
-var _chunkQOXTLPQ2cjs = require('./chunk-QOXTLPQ2.cjs');
 
 
-var _chunk3ILBFLVQcjs = require('./chunk-3ILBFLVQ.cjs');
+var _chunkMKH4Q735cjs = require('./chunk-MKH4Q735.cjs');
 
 // src/importer.ts
 var MAX_OBSERVATIONS = 5e3;
@@ -33,11 +33,11 @@ function resolveBiomarkerCode(observation) {
   } else {
     reason = "No code found in observation coding";
   }
-  const fromLoinc = loincCode ? _chunkQOXTLPQ2cjs.loincToCode.call(void 0, loincCode) : void 0;
+  const fromLoinc = loincCode ? _chunkMKH4Q735cjs.loincToCode.call(void 0, loincCode) : void 0;
   if (fromLoinc) return { internalCode: fromLoinc, loincCode, reason };
-  if (declaredCode && _chunkQOXTLPQ2cjs.isValidCode.call(void 0, declaredCode)) {
-    const canonical = _chunkQOXTLPQ2cjs.normalizeCode.call(void 0, declaredCode);
-    return { internalCode: canonical, loincCode: _chunkQOXTLPQ2cjs.codeToLoinc.call(void 0, canonical), reason };
+  if (declaredCode && _chunkMKH4Q735cjs.isValidCode.call(void 0, declaredCode)) {
+    const canonical = _chunkMKH4Q735cjs.normalizeCode.call(void 0, declaredCode);
+    return { internalCode: canonical, loincCode: _chunkMKH4Q735cjs.codeToLoinc.call(void 0, canonical), reason };
   }
   return { loincCode, reason };
 }
@@ -74,7 +74,7 @@ function mapFHIRObservationToInternal(observation, index) {
       skipped: { index, loincCode, reason, resourceType: "Observation" }
     };
   }
-  const definition = _chunkQOXTLPQ2cjs.getDefinitionByCode.call(void 0, internalCode);
+  const definition = _chunkMKH4Q735cjs.getDefinitionByCode.call(void 0, internalCode);
   let value;
   let unit = "";
   let isQualitative = false;
@@ -162,4 +162,4 @@ function processImportBundle(data) {
 
 
 exports.MAX_OBSERVATIONS = MAX_OBSERVATIONS; exports.MAX_FILE_SIZE = MAX_FILE_SIZE; exports.extractObservationsFromBundle = extractObservationsFromBundle; exports.mapFHIRObservationToInternal = mapFHIRObservationToInternal; exports.processImportBundle = processImportBundle;
-//# sourceMappingURL=chunk-SDKLR3DT.cjs.map
+//# sourceMappingURL=chunk-44QMNDOI.cjs.map

package/dist/{chunk-SDKLR3DT.cjs.map → chunk-44QMNDOI.cjs.map}

@@ -1 +1 @@
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Nesse tamanho, 5000 Observations dão 6,0MB\n * compactos ou 13,1MB indentados, e por isso o teto de arquivo é 15MB: cobre\n * as duas formas com folga.\n *\n * Na densidade desse mesmo histórico (16 Observations por laudo), 5000\n * equivalem a cerca de 300 laudos.\n */\nconst MAX_OBSERVATIONS = 5000;\nconst MAX_FILE_SIZE = 15 * 1024 * 1024; // 15MB\n\n/**\n * Resolve o código interno do biomarcador a partir do `code.coding`.\n *\n * LOINC primeiro, que é o vocabulário que arquivos de terceiros usam. Quando\n * não resolve, cai para o coding de códigos internos, presente nos arquivos\n * exportados pela própria plataforma.\n *\n * O fallback cobre dois casos: biomarcadores sem LOINC publicado (composição\n * corporal, densidade óssea, escore de cálcio) e arquivos antigos, exportados\n * quando esses biomarcadores saíam com o placeholder `99999-9`, que não\n * resolve para nada.\n */\nfunction resolveBiomarkerCode(observation: FHIRObservation): {\n  internalCode?: string;\n  loincCode?: string;\n  reason: string;\n} {\n  const coding = observation.code?.coding ?? [];\n  const loincCode = coding.find((c) => c.system === LOINC_SYSTEM)?.code;\n  const declaredCode = coding.find((c) => c.system === BIOMARKER_CODE_SYSTEM)?.code;\n\n  const seenCodes = [\n    ...(loincCode ? [`LOINC ${loincCode}`] : []),\n    ...(declaredCode ? [`biomarker code ${declaredCode}`] : []),\n  ];\n\n  // Três motivos distintos de descarte, que antes se confundiam num só. Sem\n  // essa separação, um arquivo em SNOMED relatava \"nenhum código encontrado\",\n  // sugerindo `coding` vazio quando na verdade o código existia e estava num\n  // system que não tratamos. Para importação de terceiros, é a diferença entre\n  // um diagnóstico acionável e um enigma.\n  let reason: string;\n  if (seenCodes.length > 0) {\n    reason = `Unknown code: ${seenCodes.join(', ')}`;\n  } else if (coding.length > 0) {\n    const systems = [...new Set(coding.map((c) => c.system ?? '(sem system)'))];\n    reason = `No code in a supported system (found: ${systems.join(', ')})`;\n  } else {\n    reason = 'No code found in observation coding';\n  }\n\n  const fromLoinc = loincCode ? loincToCode(loincCode) : undefined;\n  if (fromLoinc) return { internalCode: fromLoinc, loincCode, reason };\n\n  if (declaredCode && isValidCode(declaredCode)) {\n    // `isValidCode` aceita alias, mas alias não serve como código armazenado:\n    // 49 definições têm um, e tanto `codeToLoinc` quanto as faixas de\n    // referência são indexadas só pelo canônico. Sem normalizar, `VLDL_Cholesterol`\n    // entraria no lugar de `VLDL` e perderia o LOINC 13458-5 que ele tem.\n    // Importar um Bundle é fronteira de dados, que é onde `normalizeCode` deve\n    // ser aplicado.\n    const canonical = normalizeCode(declaredCode);\n\n    // `codeToLoinc` devolve undefined para quem não tem LOINC, que é o caso\n    // esperado aqui. O campo fica de fora em vez de receber um valor inventado.\n    return { internalCode: canonical, loincCode: codeToLoinc(canonical), reason };\n  }\n\n  return { loincCode, reason };\n}\n\n/**\n * Extract interpretation flag from Observation\n */\nfunction extractFlag(observation: FHIRObservation): 'H' | 'L' | '' {\n  const code = observation.interpretation?.[0]?.coding?.[0]?.code;\n  if (code === 'H' || code === 'HH') return 'H';\n  if (code === 'L' || code === 'LL') return 'L';\n  return '';\n}\n\n/**\n * Extract Observation resources from a FHIR Bundle\n */\nexport function extractObservationsFromBundle(bundle: FHIRBundle): {\n  observations: FHIRObservation[];\n  skipped: SkippedEntry[];\n} {\n  const observations: FHIRObservation[] = [];\n  const skipped: SkippedEntry[] = [];\n\n  for (let i = 0; i < bundle.entry.length; i++) {\n    const entry = bundle.entry[i]!;\n    if (!entry.resource) {\n      skipped.push({ index: i, reason: 'Entry has no resource' });\n      continue;\n    }\n\n    if (entry.resource.resourceType !== 'Observation') {\n      // Non-observation resources are silently skipped (Patient, DiagnosticReport, etc.)\n      continue;\n    }\n\n    if (observations.length >= MAX_OBSERVATIONS) {\n      skipped.push({ index: i, reason: `Maximum of ${MAX_OBSERVATIONS} observations exceeded` });\n      continue;\n    }\n\n    observations.push(entry.resource as FHIRObservation);\n  }\n\n  return { observations, skipped };\n}\n\n/**\n * Map a FHIR Observation to internal format using LOINC→biomarker code lookup\n */\nexport function mapFHIRObservationToInternal(\n  observation: FHIRObservation,\n  index: number,\n): { observation: ImportedObservation } | { skipped: SkippedEntry } {\n  const { internalCode, loincCode, reason } = resolveBiomarkerCode(observation);\n\n  if (!internalCode) {\n    return {\n      skipped: { index, loincCode, reason, resourceType: 'Observation' },\n    };\n  }\n\n  const definition = getDefinitionByCode(internalCode);\n\n  // Extract value\n  let value: number | string;\n  let unit = '';\n  let isQualitative = false;\n\n  if (observation.valueQuantity?.value !== undefined) {\n    value = observation.valueQuantity.value;\n    unit = observation.valueQuantity.unit || observation.valueQuantity.code || '';\n  } else if (observation.valueString) {\n    value = observation.valueString;\n    isQualitative = true;\n  } else {\n    return {\n      skipped: {\n        index,\n        loincCode,\n        reason: 'Observation has no value (valueQuantity or valueString)',\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  // Extract collection date (effectiveDateTime or effectivePeriod.start)\n  const collectionDate = observation.effectiveDateTime || observation.effectivePeriod?.start || '';\n  if (!collectionDate) {\n    return {\n      skipped: {\n        index,\n        loincCode,\n        reason: 'Observation has no effectiveDateTime or effectivePeriod.start',\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  // Extract reference ranges\n  let referenceMin: number | undefined;\n  let referenceMax: number | undefined;\n  if (observation.referenceRange?.[0]) {\n    referenceMin = observation.referenceRange[0].low?.value;\n    referenceMax = observation.referenceRange[0].high?.value;\n  }\n\n  const imported: ImportedObservation = {\n    biomarkerCode: internalCode,\n    biomarkerName:\n      definition?.names.pt[0] || definition?.names.en[0] || observation.code.text || internalCode,\n    collectionDate,\n    flag: extractFlag(observation),\n    isQualitative,\n    loincCode,\n    referenceMax,\n    referenceMin,\n    unit: unit || definition?.unit || '',\n    value,\n  };\n\n  return { observation: imported };\n}\n\n/**\n * Process a complete FHIR Bundle for import\n */\nexport function processImportBundle(data: unknown): FHIRImportResult {\n  // Structural validation\n  const validationErrors = validateFHIRImportBundle(data);\n  if (validationErrors.length > 0) {\n    return {\n      errors: validationErrors,\n      imported: [],\n      skipped: [],\n      totalProcessed: 0,\n    };\n  }\n\n  const bundle = data as FHIRBundle;\n\n  // Extract observations\n  const { observations, skipped } = extractObservationsFromBundle(bundle);\n\n  // Map each observation to internal format\n  const imported: ImportedObservation[] = [];\n  const allSkipped: SkippedEntry[] = [...skipped];\n\n  for (let i = 0; i < observations.length; i++) {\n    const result = mapFHIRObservationToInternal(observations[i]!, i);\n\n    if ('observation' in result) {\n      imported.push(result.observation);\n    } else {\n      allSkipped.push(result.skipped);\n    }\n  }\n\n  return {\n    errors: [],\n    imported,\n    skipped: allSkipped,\n    totalProcessed: observations.length,\n  };\n}\n\nexport { MAX_FILE_SIZE, MAX_OBSERVATIONS };\n"]}
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Nesse tamanho, 5000 Observations dão 6,0MB\n * compactos ou 13,1MB indentados, e por isso o teto de arquivo é 15MB: cobre\n * as duas formas com folga.\n *\n * Na densidade desse mesmo histórico (16 Observations por laudo), 5000\n * equivalem a cerca de 300 laudos.\n */\nconst MAX_OBSERVATIONS = 5000;\nconst MAX_FILE_SIZE = 15 * 1024 * 1024; // 15MB\n\n/**\n * Resolve o código interno do biomarcador a partir do `code.coding`.\n *\n * LOINC primeiro, que é o vocabulário que arquivos de terceiros usam. Quando\n * não resolve, cai para o coding de códigos internos, presente nos arquivos\n * exportados pela própria plataforma.\n *\n * O fallback cobre dois casos: biomarcadores sem LOINC publicado (composição\n * corporal, densidade óssea, escore de cálcio) e arquivos antigos, exportados\n * quando esses biomarcadores saíam com o placeholder `99999-9`, que não\n * resolve para nada.\n */\nfunction resolveBiomarkerCode(observation: FHIRObservation): {\n  internalCode?: string;\n  loincCode?: string;\n  reason: string;\n} {\n  const coding = observation.code?.coding ?? [];\n  const loincCode = coding.find((c) => c.system === LOINC_SYSTEM)?.code;\n  const declaredCode = coding.find((c) => c.system === BIOMARKER_CODE_SYSTEM)?.code;\n\n  const seenCodes = [\n    ...(loincCode ? [`LOINC ${loincCode}`] : []),\n    ...(declaredCode ? [`biomarker code ${declaredCode}`] : []),\n  ];\n\n  // Três motivos distintos de descarte, que antes se confundiam num só. Sem\n  // essa separação, um arquivo em SNOMED relatava \"nenhum código encontrado\",\n  // sugerindo `coding` vazio quando na verdade o código existia e estava num\n  // system que não tratamos. Para importação de terceiros, é a diferença entre\n  // um diagnóstico acionável e um enigma.\n  let reason: string;\n  if (seenCodes.length > 0) {\n    reason = `Unknown code: ${seenCodes.join(', ')}`;\n  } else if (coding.length > 0) {\n    const systems = [...new Set(coding.map((c) => c.system ?? '(sem system)'))];\n    reason = `No code in a supported system (found: ${systems.join(', ')})`;\n  } else {\n    reason = 'No code found in observation coding';\n  }\n\n  const fromLoinc = loincCode ? loincToCode(loincCode) : undefined;\n  if (fromLoinc) return { internalCode: fromLoinc, loincCode, reason };\n\n  if (declaredCode && isValidCode(declaredCode)) {\n    // `isValidCode` aceita alias, mas alias não serve como código armazenado:\n    // 49 definições têm um, e tanto `codeToLoinc` quanto as faixas de\n    // referência são indexadas só pelo canônico. Sem normalizar, `VLDL_Cholesterol`\n    // entraria no lugar de `VLDL` e perderia o LOINC 13458-5 que ele tem.\n    // Importar um Bundle é fronteira de dados, que é onde `normalizeCode` deve\n    // ser aplicado.\n    const canonical = normalizeCode(declaredCode);\n\n    // `codeToLoinc` devolve undefined para quem não tem LOINC, que é o caso\n    // esperado aqui. O campo fica de fora em vez de receber um valor inventado.\n    return { internalCode: canonical, loincCode: codeToLoinc(canonical), reason };\n  }\n\n  return { loincCode, reason };\n}\n\n/**\n * Extract interpretation flag from Observation\n */\nfunction extractFlag(observation: FHIRObservation): 'H' | 'L' | '' {\n  const code = observation.interpretation?.[0]?.coding?.[0]?.code;\n  if (code === 'H' || code === 'HH') return 'H';\n  if (code === 'L' || code === 'LL') return 'L';\n  return '';\n}\n\n/**\n * Extract Observation resources from a FHIR Bundle\n */\nexport function extractObservationsFromBundle(bundle: FHIRBundle): {\n  observations: FHIRObservation[];\n  skipped: SkippedEntry[];\n} {\n  const observations: FHIRObservation[] = [];\n  const skipped: SkippedEntry[] = [];\n\n  for (let i = 0; i < bundle.entry.length; i++) {\n    const entry = bundle.entry[i]!;\n    if (!entry.resource) {\n      skipped.push({ index: i, reason: 'Entry has no resource' });\n      continue;\n    }\n\n    if (entry.resource.resourceType !== 'Observation') {\n      // Non-observation resources are silently skipped (Patient, DiagnosticReport, etc.)\n      continue;\n    }\n\n    if (observations.length >= MAX_OBSERVATIONS) {\n      skipped.push({ index: i, reason: `Maximum of ${MAX_OBSERVATIONS} observations exceeded` });\n      continue;\n    }\n\n    observations.push(entry.resource as FHIRObservation);\n  }\n\n  return { observations, skipped };\n}\n\n/**\n * Map a FHIR Observation to internal format using LOINC→biomarker code lookup\n */\nexport function mapFHIRObservationToInternal(\n  observation: FHIRObservation,\n  index: number,\n): { observation: ImportedObservation } | { skipped: SkippedEntry } {\n  const { internalCode, loincCode, reason } = resolveBiomarkerCode(observation);\n\n  if (!internalCode) {\n    return {\n      skipped: { index, loincCode, reason, resourceType: 'Observation' },\n    };\n  }\n\n  const definition = getDefinitionByCode(internalCode);\n\n  // Extract value\n  let value: number | string;\n  let unit = '';\n  let isQualitative = false;\n\n  if (observation.valueQuantity?.value !== undefined) {\n    value = observation.valueQuantity.value;\n    unit = observation.valueQuantity.unit || observation.valueQuantity.code || '';\n  } else if (observation.valueString) {\n    value = observation.valueString;\n    isQualitative = true;\n  } else {\n    return {\n      skipped: {\n        index,\n        loincCode,\n        reason: 'Observation has no value (valueQuantity or valueString)',\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  // Extract collection date (effectiveDateTime or effectivePeriod.start)\n  const collectionDate = observation.effectiveDateTime || observation.effectivePeriod?.start || '';\n  if (!collectionDate) {\n    return {\n      skipped: {\n        index,\n        loincCode,\n        reason: 'Observation has no effectiveDateTime or effectivePeriod.start',\n        resourceType: 'Observation',\n      },\n    };\n  }\n\n  // Extract reference ranges\n  let referenceMin: number | undefined;\n  let referenceMax: number | undefined;\n  if (observation.referenceRange?.[0]) {\n    referenceMin = observation.referenceRange[0].low?.value;\n    referenceMax = observation.referenceRange[0].high?.value;\n  }\n\n  const imported: ImportedObservation = {\n    biomarkerCode: internalCode,\n    biomarkerName:\n      definition?.names.pt[0] || definition?.names.en[0] || observation.code.text || internalCode,\n    collectionDate,\n    flag: extractFlag(observation),\n    isQualitative,\n    loincCode,\n    referenceMax,\n    referenceMin,\n    unit: unit || definition?.unit || '',\n    value,\n  };\n\n  return { observation: imported };\n}\n\n/**\n * Process a complete FHIR Bundle for import\n */\nexport function processImportBundle(data: unknown): FHIRImportResult {\n  // Structural validation\n  const validationErrors = validateFHIRImportBundle(data);\n  if (validationErrors.length > 0) {\n    return {\n      errors: validationErrors,\n      imported: [],\n      skipped: [],\n      totalProcessed: 0,\n    };\n  }\n\n  const bundle = data as FHIRBundle;\n\n  // Extract observations\n  const { observations, skipped } = extractObservationsFromBundle(bundle);\n\n  // Map each observation to internal format\n  const imported: ImportedObservation[] = [];\n  const allSkipped: SkippedEntry[] = [...skipped];\n\n  for (let i = 0; i < observations.length; i++) {\n    const result = mapFHIRObservationToInternal(observations[i]!, i);\n\n    if ('observation' in result) {\n      imported.push(result.observation);\n    } else {\n      allSkipped.push(result.skipped);\n    }\n  }\n\n  return {\n    errors: [],\n    imported,\n    skipped: allSkipped,\n    totalProcessed: observations.length,\n  };\n}\n\nexport { MAX_FILE_SIZE, MAX_OBSERVATIONS };\n"]}

package/dist/{chunk-RM7KJAVA.js → chunk-4Y43MQQK.js}

@@ -1,3 +1,6 @@
+import {
+  validateFHIRImportBundle
+} from "./chunk-N3ZCOLG2.js";
 import {
   BIOMARKER_CODE_SYSTEM,
   LOINC_SYSTEM
@@ -8,10 +11,7 @@ import {
   isValidCode,
   loincToCode,
   normalizeCode
-} from "./chunk-PK5DQMPC.js";
-import {
-  validateFHIRImportBundle
-} from "./chunk-N3ZCOLG2.js";
+} from "./chunk-WDDW2WCY.js";
 
 // src/importer.ts
 var MAX_OBSERVATIONS = 5e3;
@@ -162,4 +162,4 @@ export {
   mapFHIRObservationToInternal,
   processImportBundle
 };
-//# sourceMappingURL=chunk-RM7KJAVA.js.map
+//# sourceMappingURL=chunk-4Y43MQQK.js.map

package/dist/chunk-5FMR2U7P.cjs

@@ -0,0 +1,342 @@
+"use strict";Object.defineProperty(exports, "__esModule", {value: true}); function _nullishCoalesce(lhs, rhsFn) { if (lhs != null) { return lhs; } else { return rhsFn(); } }// src/sources.ts
+var SOURCE_REGISTRY = {
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Cardiovascular
+  // ---------------------------------------------------------------------------
+  "agatston-1990": {
+    abnt: "AGATSTON, A. S. et al. Quantification of coronary artery calcium using ultrafast computed tomography. Journal of the American College of Cardiology, v. 15, n. 4, p. 827-832, 1990.",
+    doi: "10.1016/0735-1097(90)90282-T",
+    key: "agatston-1990",
+    url: "https://pubmed.ncbi.nlm.nih.gov/2407762/"
+  },
+  "browning-ashwell-2010": {
+    abnt: "BROWNING, L. M.; HSIEH, S. D.; ASHWELL, M. A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0,5 could be a suitable global boundary value. Nutrition Research Reviews, v. 23, n. 2, p. 247-269, 2010.",
+    doi: "10.1017/S0954422410000144",
+    key: "browning-ashwell-2010",
+    url: "https://pubmed.ncbi.nlm.nih.gov/20819243/"
+  },
+  "castelli-ratio-1992": {
+    abnt: "CASTELLI, W. P. et al. Lipids and risk of coronary heart disease: the Framingham Study. Annals of Epidemiology, v. 2, n. 1-2, p. 23-28, 1992.",
+    doi: "10.1016/1047-2797(92)90033-M",
+    key: "castelli-ratio-1992",
+    url: "https://pubmed.ncbi.nlm.nih.gov/1342260/"
+  },
+  "caulfield-ionmobility-2008": {
+    abnt: "CAULFIELD, M. P. et al. Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis. Clinical Chemistry, v. 54, n. 8, p. 1307-1316, 2008.",
+    doi: "10.1373/clinchem.2007.100586",
+    key: "caulfield-ionmobility-2008",
+    url: "https://pubmed.ncbi.nlm.nih.gov/18515257/"
+  },
+  "contois-apoa1-1996": {
+    abnt: "CONTOIS, J. H. et al. Reference intervals for plasma apolipoprotein A-1 determined with a standardized commercial immunoturbidimetric assay: results from the Framingham Offspring Study. Clinical Chemistry, v. 42, n. 4, p. 507-514, 1996.",
+    doi: "10.1093/clinchem/42.4.507",
+    key: "contois-apoa1-1996",
+    url: "https://pubmed.ncbi.nlm.nih.gov/8605666/"
+  },
+  "ewgsop2-2019": {
+    abnt: "CRUZ-JENTOFT, A. J. et al. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing, v. 48, n. 1, p. 16-31, 2019.",
+    doi: "10.1093/ageing/afy169",
+    key: "ewgsop2-2019",
+    url: "https://pubmed.ncbi.nlm.nih.gov/30312372/"
+  },
+  "ferreira-vitd-2017": {
+    abnt: "FERREIRA, C. E. S. et al. Posicionamento oficial da Sociedade Brasileira de Patologia Cl\xEDnica/Medicina Laboratorial e da Sociedade Brasileira de Endocrinologia e Metabologia sobre intervalos de refer\xEAncia da vitamina D [25(OH)D]. Archives of Endocrinology and Metabolism, v. 61, n. 6, p. 527-542, 2017.",
+    doi: "10.1590/2359-3997000000310",
+    key: "ferreira-vitd-2017",
+    url: "https://pubmed.ncbi.nlm.nih.gov/29412389/"
+  },
+  "friedewald-1972": {
+    abnt: "FRIEDEWALD, W. T.; LEVY, R. I.; FREDRICKSON, D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, v. 18, n. 6, p. 499-502, 1972.",
+    doi: "10.1093/clinchem/18.6.499",
+    key: "friedewald-1972",
+    url: "https://pubmed.ncbi.nlm.nih.gov/4337382/"
+  },
+  "gallagher-bodyfat-2000": {
+    abnt: "GALLAGHER, D. et al. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. American Journal of Clinical Nutrition, v. 72, n. 3, p. 694-701, 2000.",
+    key: "gallagher-bodyfat-2000",
+    url: "https://pubmed.ncbi.nlm.nih.gov/10966886/"
+  },
+  "ge-corescan": {
+    abnt: "GE HEALTHCARE. enCORE Software CoreScan: Visceral Adipose Tissue (VAT) assessment. Madison: GE Medical Systems Lunar, [s. d.]. (Documenta\xE7\xE3o do fabricante do DEXA Lunar Prodigy; classifica\xE7\xE3o Healthy 0\u201352 in\xB3, Increased Risk 52,15\u2013112,10 in\xB3, At Risk 112,10+ in\xB3, equivalente a 0\u2013852 cm\xB3, 854\u20131.837 cm\xB3, 1.837+ cm\xB3.)",
+    key: "ge-corescan",
+    url: "https://www.gehealthcare.com/products/bone-and-metabolic-health/encore"
+  },
+  "geloneze-brams-2009": {
+    abnt: "GELONEZE, B. et al. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome \u2014 Brazilian Metabolic Syndrome Study (BRAMS). Arquivos Brasileiros de Endocrinologia & Metabologia, v. 53, n. 2, p. 281-287, 2009.",
+    doi: "10.1590/S0004-27302009000200020",
+    key: "geloneze-brams-2009",
+    url: "https://pubmed.ncbi.nlm.nih.gov/19466221/"
+  },
+  "george-ck-2016": {
+    abnt: "GEORGE, M. D.; MCGILL, N. K.; BAKER, J. F. Creatine kinase in the U.S. population: impact of demographics, comorbidities, and body composition on the normal range. Medicine, v. 95, n. 33, e4344, 2016.",
+    doi: "10.1097/MD.0000000000004344",
+    key: "george-ck-2016",
+    url: "https://pubmed.ncbi.nlm.nih.gov/27537560/"
+  },
+  "giannitsis-hstnt-2010": {
+    abnt: "GIANNITSIS, E. et al. Analytical validation of a high-sensitivity cardiac troponin T assay. Clinical Chemistry, v. 56, n. 2, p. 254-261, 2010.",
+    doi: "10.1373/clinchem.2009.132654",
+    key: "giannitsis-hstnt-2010",
+    url: "https://pubmed.ncbi.nlm.nih.gov/19959623/"
+  },
+  "glis-2024": {
+    abnt: "KIRK, B. et al. The conceptual definition of sarcopenia: Delphi consensus from the Global Leadership Initiative in Sarcopenia (GLIS). Age and Ageing, v. 53, n. 3, afae052, 2024.",
+    doi: "10.1093/ageing/afae052",
+    key: "glis-2024",
+    url: "https://pubmed.ncbi.nlm.nih.gov/38520141/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Ácidos graxos ômega
+  // ---------------------------------------------------------------------------
+  "harris-omega3-2004": {
+    abnt: "HARRIS, W. S.; VON SCHACKY, C. The Omega-3 Index: a new risk factor for death from coronary heart disease? Preventive Medicine, v. 39, n. 1, p. 212-220, 2004.",
+    doi: "10.1016/j.ypmed.2004.02.030",
+    key: "harris-omega3-2004",
+    url: "https://pubmed.ncbi.nlm.nih.gov/15208005/"
+  },
+  // ---------------------------------------------------------------------------
+  // Referência laboratorial geral
+  // ---------------------------------------------------------------------------
+  "kalaria-ck-ri-2026": {
+    abnt: "KALARIA, T. et al. Age, sex and ethnicity changes in creatine kinase and sex- and ethnicity-specific reference intervals of creatine kinase. Clinical Medicine, v. 26, n. 4, p. 100596, 2026.",
+    doi: "10.1016/j.clinme.2026.100596",
+    key: "kalaria-ck-ri-2026",
+    url: "https://pubmed.ncbi.nlm.nih.gov/42142664/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Nefrologia
+  // ---------------------------------------------------------------------------
+  "kdigo-ckd-2024": {
+    abnt: "KIDNEY DISEASE: IMPROVING GLOBAL OUTCOMES (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International, v. 105, n. 4S, p. S117-S314, 2024.",
+    doi: "10.1016/j.kint.2023.10.018",
+    key: "kdigo-ckd-2024",
+    url: "https://pubmed.ncbi.nlm.nih.gov/38490803/"
+  },
+  "keller-tni-2013": {
+    abnt: "KELLER, T. et al. Defining a reference population to determine the 99th percentile of a contemporary sensitive cardiac troponin I assay. International Journal of Cardiology, v. 167, n. 4, p. 1423-1429, 2013.",
+    doi: "10.1016/j.ijcard.2012.04.063",
+    key: "keller-tni-2013",
+    url: "https://pubmed.ncbi.nlm.nih.gov/22560907/"
+  },
+  "kelly-dxa-2009": {
+    abnt: "KELLY, T. L. et al. Dual energy X-ray absorptiometry body composition reference values from NHANES. PLoS One, v. 4, n. 9, e7038, 2009.",
+    doi: "10.1371/journal.pone.0007038",
+    key: "kelly-dxa-2009",
+    url: "https://pubmed.ncbi.nlm.nih.gov/19753111/"
+  },
+  "khetarpal-apociii-2016": {
+    abnt: "KHETARPAL, S. A. et al. Why is apolipoprotein CIII emerging as a novel therapeutic target to reduce the burden of cardiovascular disease? Current Atherosclerosis Reports, v. 18, n. 10, p. 59, 2016.",
+    key: "khetarpal-apociii-2016",
+    url: "https://pmc.ncbi.nlm.nih.gov/articles/PMC5018018/"
+  },
+  "klee-bhb-2020": {
+    abnt: "KLEE, P. et al. Test validation, method comparison and reference range for the measurement of \u03B2-hydroxybutyrate in peripheral blood samples. Practical Laboratory Medicine, v. 18, e00146, 2020.",
+    doi: "10.1016/j.plabm.2019.e00146",
+    key: "klee-bhb-2020",
+    url: "https://pmc.ncbi.nlm.nih.gov/articles/PMC6999181/"
+  },
+  "maisel-bnp-2002": {
+    abnt: "MAISEL, A. S. et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. New England Journal of Medicine, v. 347, n. 3, p. 161-167, 2002.",
+    doi: "10.1056/NEJMoa020233",
+    key: "maisel-bnp-2002",
+    url: "https://pubmed.ncbi.nlm.nih.gov/12124404/"
+  },
+  "meuwese-mpo-2007": {
+    abnt: "MEUWESE, M. C. et al. Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study. Journal of the American College of Cardiology, v. 50, n. 2, p. 159-165, 2007.",
+    doi: "10.1016/j.jacc.2007.03.033",
+    key: "meuwese-mpo-2007",
+    url: "https://pubmed.ncbi.nlm.nih.gov/17616301/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Marcadores metabólicos e inflamatórios
+  // ---------------------------------------------------------------------------
+  "nemeth-adma-2017": {
+    abnt: "NEMETH, B. et al. The issue of plasma asymmetric dimethylarginine reference range: a systematic review and meta-analysis. PLoS One, v. 12, n. 5, e0177493, 2017.",
+    doi: "10.1371/journal.pone.0177493",
+    key: "nemeth-adma-2017",
+    url: "https://pubmed.ncbi.nlm.nih.gov/28494019/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes brasileiras — Metais pesados (NR-7)
+  // ---------------------------------------------------------------------------
+  "nr7-pcmso-2020": {
+    abnt: "BRASIL. Minist\xE9rio do Trabalho e Emprego. NR-7 \u2014 PCMSO, Quadro 1: Indicadores biol\xF3gicos. Portaria n. 6.734, de 9 de mar\xE7o de 2020. Di\xE1rio Oficial da Uni\xE3o, Bras\xEDlia, 13 mar. 2020.",
+    key: "nr7-pcmso-2020",
+    url: "https://www.gov.br/trabalho-e-emprego/pt-br/assuntos/inspecao-do-trabalho/seguranca-e-saude-no-trabalho/sst-portarias/2022/portaria-no-567-de-10-de-marco-de-2022-alteracoes-na-nr-7.pdf"
+  },
+  "ofenheimer-vat-2020": {
+    abnt: "OFENHEIMER, A. et al. Reference values of body composition parameters and visceral adipose tissue (VAT) by DXA in adults aged 18-81 years: results from the LEAD cohort. European Journal of Clinical Nutrition, v. 74, p. 1181-1191, 2020.",
+    doi: "10.1038/s41430-020-0596-5",
+    key: "ofenheimer-vat-2020",
+    url: "https://pubmed.ncbi.nlm.nih.gov/32123345/"
+  },
+  "pns-bioquimica-2019": {
+    abnt: "SZWARCWALD, C. L. et al. Valores de refer\xEAncia para exames laboratoriais de colesterol, hemoglobina glicosilada e creatinina da popula\xE7\xE3o adulta brasileira. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190002.supl.2, 2019.",
+    doi: "10.1590/1980-549720190002.supl.2",
+    key: "pns-bioquimica-2019",
+    url: "https://pubmed.ncbi.nlm.nih.gov/31596373/"
+  },
+  // ---------------------------------------------------------------------------
+  // Pesquisa Nacional de Saúde (PNS) — Intervalos de referência brasileiros
+  // ---------------------------------------------------------------------------
+  "pns-hemograma-2019": {
+    abnt: "ROSENFELD, L. G. et al. Valores de refer\xEAncia para exames laboratoriais de hemograma da popula\xE7\xE3o adulta brasileira: Pesquisa Nacional de Sa\xFAde. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190003.supl.2, 2019.",
+    doi: "10.1590/1980-549720190003.supl.2",
+    key: "pns-hemograma-2019",
+    url: "https://pubmed.ncbi.nlm.nih.gov/31596374/"
+  },
+  "pns-renal-2019": {
+    abnt: "MALTA, D. C. et al. Evaluation of renal function in the Brazilian adult population, according to laboratory criteria from the National Health Survey. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190010.supl.2, 2019.",
+    doi: "10.1590/1980-549720190010.supl.2",
+    key: "pns-renal-2019",
+    url: "https://pubmed.ncbi.nlm.nih.gov/31596381/"
+  },
+  "rumberger-cac-1999": {
+    abnt: "RUMBERGER, J. A. et al. Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons. Mayo Clinic Proceedings, v. 74, n. 3, p. 243-252, 1999.",
+    doi: "10.4065/74.3.243",
+    key: "rumberger-cac-1999",
+    url: "https://pubmed.ncbi.nlm.nih.gov/10089993/"
+  },
+  "sbc-ic-2018": {
+    abnt: "ROHDE, L. E. P. et al. Diretriz Brasileira de Insufici\xEAncia Card\xEDaca Cr\xF4nica e Aguda. Arquivos Brasileiros de Cardiologia, S\xE3o Paulo, v. 111, n. 3, p. 436-539, set. 2018.",
+    doi: "10.5935/abc.20180190",
+    key: "sbc-ic-2018",
+    url: "https://pubmed.ncbi.nlm.nih.gov/30379264/"
+  },
+  // ---------------------------------------------------------------------------
+  // Sociedade Brasileira de Cardiologia
+  // ---------------------------------------------------------------------------
+  "sbc-lipids-2017": {
+    abnt: "FALUDI, A. A. et al. Atualiza\xE7\xE3o da Diretriz Brasileira de Dislipidemias e Preven\xE7\xE3o da Aterosclerose \u2013 2017. Arquivos Brasileiros de Cardiologia, S\xE3o Paulo, v. 109, n. 2, supl. 1, p. 1-76, ago. 2017.",
+    doi: "10.5935/abc.20170121",
+    key: "sbc-lipids-2017",
+    url: "https://www.scielo.br/j/abc/a/whBsCyzTDzGYJcsBY7YVkWn/?lang=pt"
+  },
+  "sbc-lipids-2025": {
+    abnt: "RACHED, F. H. et al. Diretriz Brasileira de Dislipidemias e Preven\xE7\xE3o da Aterosclerose \u2013 2025. Arquivos Brasileiros de Cardiologia, S\xE3o Paulo, v. 122, n. 9, e20250640, out. 2025.",
+    doi: "10.36660/abc.20250640",
+    key: "sbc-lipids-2025",
+    url: "https://pmc.ncbi.nlm.nih.gov/articles/PMC12674852/"
+  },
+  // ---------------------------------------------------------------------------
+  // Sociedade Brasileira de Diabetes
+  // ---------------------------------------------------------------------------
+  "sbd-diabetes-2024": {
+    // Chave mantida como 'sbd-diabetes-2024' para compatibilidade com
+    // consumidores publicados; a diretriz correspondente é o documento vivo
+    // de diretriz.diabetes.org.br, cuja edição citada quando este registro foi
+    // atualizado é "Edição 2025". Semelhante ao caso de sbpc-ml-2021 abaixo.
+    abnt: "SOCIEDADE BRASILEIRA DE DIABETES (SBD). Diretriz da Sociedade Brasileira de Diabetes \u2014 Edi\xE7\xE3o 2025. S\xE3o Paulo: SBD, 2025.",
+    doi: "10.29327/5660187",
+    isbn: "978-65-272-1932-3",
+    key: "sbd-diabetes-2024",
+    url: "https://diretriz.diabetes.org.br"
+  },
+  // ---------------------------------------------------------------------------
+  // Sociedade Brasileira de Endocrinologia e Metabologia
+  // ---------------------------------------------------------------------------
+  "sbem-thyroid-2013": {
+    abnt: "SGARBI, J. A. et al. Consenso brasileiro para a abordagem cl\xEDnica e tratamento do hipotireoidismo subcl\xEDnico em adultos. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 57, n. 3, p. 166-183, 2013.",
+    doi: "10.1590/S0004-27302013000300003",
+    key: "sbem-thyroid-2013",
+    url: "https://pubmed.ncbi.nlm.nih.gov/23681263/"
+  },
+  "sbem-vitamind-2014": {
+    abnt: "MAEDA, S. S. et al. Recomenda\xE7\xF5es da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagn\xF3stico e tratamento da hipovitaminose D. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 58, n. 5, p. 411-433, 2014.",
+    doi: "10.1590/0004-2730000003388",
+    key: "sbem-vitamind-2014",
+    url: "https://pubmed.ncbi.nlm.nih.gov/25166032/"
+  },
+  // ---------------------------------------------------------------------------
+  // Sociedade Brasileira de Patologia Clínica / Medicina Laboratorial
+  // ---------------------------------------------------------------------------
+  "sbpc-ml-2021": {
+    // Chave mantida como 'sbpc-ml-2021' para compatibilidade com consumidores;
+    // a edição autoritativa é de 2020 (verificada na Biblioteca Digital SBPC/ML
+    // em 2026-04-18). Ano na citação ABNT reflete a edição real.
+    abnt: "SOCIEDADE BRASILEIRA DE PATOLOGIA CL\xCDNICA/MEDICINA LABORATORIAL (SBPC/ML). Recomenda\xE7\xF5es da Sociedade Brasileira de Patologia Cl\xEDnica/Medicina Laboratorial (SBPC/ML): Boas Pr\xE1ticas em Laborat\xF3rio Cl\xEDnico. S\xE3o Paulo: SBPC/ML, 2020.",
+    key: "sbpc-ml-2021",
+    url: "https://bibliotecasbpc.org.br/index.php?P=4&C=0.2.443"
+  },
+  "schumann-ifcc-ldh-2002": {
+    abnt: "SCHUMANN, G.; KLAUKE, R. New IFCC reference procedures for the determination of catalytic activity concentrations of five enzymes in serum: preliminary upper reference limits obtained in hospitalized subjects. Clinica Chimica Acta, v. 327, n. 1-2, p. 69-79, 2003.",
+    doi: "10.1016/S0009-8981(02)00341-8",
+    key: "schumann-ifcc-ldh-2002",
+    url: "https://pubmed.ncbi.nlm.nih.gov/12482620/"
+  },
+  "schwedhelm-sdma-2011": {
+    abnt: "SCHWEDHELM, E. et al. Plasma symmetric dimethylarginine reference limits from the Framingham Offspring Cohort. Clinical Chemistry and Laboratory Medicine, v. 49, n. 11, p. 1907-1910, 2011.",
+    doi: "10.1515/CCLM.2011.679",
+    key: "schwedhelm-sdma-2011",
+    url: "https://pubmed.ncbi.nlm.nih.gov/21864208/"
+  },
+  "selhub-homocysteine-1999": {
+    abnt: "SELHUB, J. et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Annals of Internal Medicine, v. 131, n. 5, p. 331-339, 1999.",
+    doi: "10.7326/0003-4819-131-5-199909070-00003",
+    key: "selhub-homocysteine-1999",
+    url: "https://pubmed.ncbi.nlm.nih.gov/10475885/"
+  },
+  "simopoulos-omega-ratio-2002": {
+    abnt: "SIMOPOULOS, A. P. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy, v. 56, n. 8, p. 365-379, 2002.",
+    doi: "10.1016/S0753-3322(02)00253-6",
+    key: "simopoulos-omega-ratio-2002",
+    url: "https://pubmed.ncbi.nlm.nih.gov/12442909/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Marcadores tumorais
+  // ---------------------------------------------------------------------------
+  "sturgeon-nacb-2008": {
+    abnt: "STURGEON, C. M. et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers. Clinical Chemistry, v. 54, n. 12, p. e11-e79, 2008.",
+    doi: "10.1373/clinchem.2008.105601",
+    key: "sturgeon-nacb-2008",
+    url: "https://pubmed.ncbi.nlm.nih.gov/19042984/"
+  },
+  "tietz-7ed-2015": {
+    abnt: "BURTIS, C. A.; BRUNS, D. E. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. 7. ed. St. Louis: Elsevier Saunders, 2015.",
+    isbn: "978-1-4557-4165-6",
+    key: "tietz-7ed-2015"
+  },
+  "torrissen-omega3-dbs-2025": {
+    abnt: "TORRISSEN, M. et al. Global variations in omega-3 fatty acid status and omega-6:omega-3 ratios: insights from > 500,000 whole-blood dried blood spot samples. Lipids in Health and Disease, v. 24, n. 1, p. 260, 2025.",
+    doi: "10.1186/s12944-025-02676-6",
+    key: "torrissen-omega3-dbs-2025",
+    url: "https://pubmed.ncbi.nlm.nih.gov/40783537/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — Coagulação
+  // ---------------------------------------------------------------------------
+  "wells-ddimer-2003": {
+    abnt: "WELLS, P. S. et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. New England Journal of Medicine, v. 349, p. 1227-1235, 2003.",
+    doi: "10.1056/NEJMoa023153",
+    key: "wells-ddimer-2003",
+    url: "https://pubmed.ncbi.nlm.nih.gov/14507948/"
+  },
+  // ---------------------------------------------------------------------------
+  // Fontes internacionais — OMS
+  // ---------------------------------------------------------------------------
+  "who-iron-2020": {
+    abnt: "WORLD HEALTH ORGANIZATION. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. Geneva: WHO, 2020.",
+    isbn: "978-92-4-000012-4",
+    key: "who-iron-2020",
+    url: "https://www.who.int/publications/i/item/9789240000124"
+  },
+  "who-obesity-2000": {
+    abnt: "WORLD HEALTH ORGANIZATION. Obesity: preventing and managing the global epidemic. WHO Technical Report Series, n. 894. Geneva: WHO, 2000.",
+    isbn: "92-4-120894-5",
+    key: "who-obesity-2000"
+  },
+  "who-osteoporosis-1994": {
+    abnt: "WHO STUDY GROUP. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report Series, n. 843. Geneva: WHO, 1994.",
+    key: "who-osteoporosis-1994",
+    url: "https://pubmed.ncbi.nlm.nih.gov/7941614/"
+  }
+};
+function extractSourceKey(source) {
+  return _nullishCoalesce(source.split(":")[0], () => ( source));
+}
+
+
+
+
+exports.SOURCE_REGISTRY = SOURCE_REGISTRY; exports.extractSourceKey = extractSourceKey;
+//# sourceMappingURL=chunk-5FMR2U7P.cjs.map

package/dist/chunk-5FMR2U7P.cjs.map

@@ -0,0 +1 @@
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* Registro de fontes bibliográficas para faixas de referência de biomarcadores.\n *\n * Exportado na API pública desde a 0.32: o campo `source` de cada faixa é uma\n * chave, e sem o registro ao lado ela não resolve para lugar nenhum. Quem\n * consome via `@precisa-saude/fhir/sources` ou pelo `fhir-bio source`.\n *\n * Todas as citações seguem o formato ABNT (NBR 6023).\n */\n\n/**\n * Referência bibliográfica completa para uma fonte de faixas de referência.\n */\nexport interface SourceReference {\n  /** Citação completa em formato ABNT (NBR 6023) */\n  abnt: string;\n  /** DOI, quando disponível */\n  doi?: string;\n  /** ISBN, quando aplicável */\n  isbn?: string;\n  /** Chave curta usada no campo `source` de BiomarkerRangeDefinition */\n  key: string;\n  /** URL de acesso */\n  url?: string;\n}\n\n/**\n * Registro central de todas as fontes bibliográficas utilizadas nas faixas de referência.\n *\n * Cada chave corresponde ao valor usado no campo `source` de `BiomarkerRangeDefinition`\n * (sem o sufixo de localização, ex: `'sbc-lipids-2017'` sem `':p15'`).\n */\nexport const SOURCE_REGISTRY: Record<string, SourceReference> = {\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Cardiovascular\n  // ---------------------------------------------------------------------------\n  'agatston-1990': {\n    abnt: 'AGATSTON, A. S. et al. Quantification of coronary artery calcium using ultrafast computed tomography. Journal of the American College of Cardiology, v. 15, n. 4, p. 827-832, 1990.',\n    doi: '10.1016/0735-1097(90)90282-T',\n    key: 'agatston-1990',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/2407762/',\n  },\n\n  'browning-ashwell-2010': {\n    abnt: 'BROWNING, L. M.; HSIEH, S. D.; ASHWELL, M. A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0,5 could be a suitable global boundary value. Nutrition Research Reviews, v. 23, n. 2, p. 247-269, 2010.',\n    doi: '10.1017/S0954422410000144',\n    key: 'browning-ashwell-2010',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/20819243/',\n  },\n\n  'castelli-ratio-1992': {\n    abnt: 'CASTELLI, W. P. et al. Lipids and risk of coronary heart disease: the Framingham Study. Annals of Epidemiology, v. 2, n. 1-2, p. 23-28, 1992.',\n    doi: '10.1016/1047-2797(92)90033-M',\n    key: 'castelli-ratio-1992',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/1342260/',\n  },\n\n  'caulfield-ionmobility-2008': {\n    abnt: 'CAULFIELD, M. P. et al. Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis. Clinical Chemistry, v. 54, n. 8, p. 1307-1316, 2008.',\n    doi: '10.1373/clinchem.2007.100586',\n    key: 'caulfield-ionmobility-2008',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/18515257/',\n  },\n\n  'contois-apoa1-1996': {\n    abnt: 'CONTOIS, J. H. et al. Reference intervals for plasma apolipoprotein A-1 determined with a standardized commercial immunoturbidimetric assay: results from the Framingham Offspring Study. Clinical Chemistry, v. 42, n. 4, p. 507-514, 1996.',\n    doi: '10.1093/clinchem/42.4.507',\n    key: 'contois-apoa1-1996',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/8605666/',\n  },\n\n  'ewgsop2-2019': {\n    abnt: 'CRUZ-JENTOFT, A. J. et al. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing, v. 48, n. 1, p. 16-31, 2019.',\n    doi: '10.1093/ageing/afy169',\n    key: 'ewgsop2-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/30312372/',\n  },\n\n  'ferreira-vitd-2017': {\n    abnt: 'FERREIRA, C. E. S. et al. Posicionamento oficial da Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial e da Sociedade Brasileira de Endocrinologia e Metabologia sobre intervalos de referência da vitamina D [25(OH)D]. Archives of Endocrinology and Metabolism, v. 61, n. 6, p. 527-542, 2017.',\n    doi: '10.1590/2359-3997000000310',\n    key: 'ferreira-vitd-2017',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/29412389/',\n  },\n\n  'friedewald-1972': {\n    abnt: 'FRIEDEWALD, W. T.; LEVY, R. I.; FREDRICKSON, D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, v. 18, n. 6, p. 499-502, 1972.',\n    doi: '10.1093/clinchem/18.6.499',\n    key: 'friedewald-1972',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/4337382/',\n  },\n\n  'gallagher-bodyfat-2000': {\n    abnt: 'GALLAGHER, D. et al. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. American Journal of Clinical Nutrition, v. 72, n. 3, p. 694-701, 2000.',\n    key: 'gallagher-bodyfat-2000',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/10966886/',\n  },\n\n  'ge-corescan': {\n    abnt: 'GE HEALTHCARE. enCORE Software CoreScan: Visceral Adipose Tissue (VAT) assessment. Madison: GE Medical Systems Lunar, [s. d.]. (Documentação do fabricante do DEXA Lunar Prodigy; classificação Healthy 0–52 in³, Increased Risk 52,15–112,10 in³, At Risk 112,10+ in³, equivalente a 0–852 cm³, 854–1.837 cm³, 1.837+ cm³.)',\n    key: 'ge-corescan',\n    url: 'https://www.gehealthcare.com/products/bone-and-metabolic-health/encore',\n  },\n\n  'geloneze-brams-2009': {\n    abnt: 'GELONEZE, B. et al. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome — Brazilian Metabolic Syndrome Study (BRAMS). Arquivos Brasileiros de Endocrinologia & Metabologia, v. 53, n. 2, p. 281-287, 2009.',\n    doi: '10.1590/S0004-27302009000200020',\n    key: 'geloneze-brams-2009',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19466221/',\n  },\n\n  'george-ck-2016': {\n    abnt: 'GEORGE, M. D.; MCGILL, N. K.; BAKER, J. F. Creatine kinase in the U.S. population: impact of demographics, comorbidities, and body composition on the normal range. Medicine, v. 95, n. 33, e4344, 2016.',\n    doi: '10.1097/MD.0000000000004344',\n    key: 'george-ck-2016',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/27537560/',\n  },\n\n  'giannitsis-hstnt-2010': {\n    abnt: 'GIANNITSIS, E. et al. Analytical validation of a high-sensitivity cardiac troponin T assay. Clinical Chemistry, v. 56, n. 2, p. 254-261, 2010.',\n    doi: '10.1373/clinchem.2009.132654',\n    key: 'giannitsis-hstnt-2010',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19959623/',\n  },\n\n  'glis-2024': {\n    abnt: 'KIRK, B. et al. The conceptual definition of sarcopenia: Delphi consensus from the Global Leadership Initiative in Sarcopenia (GLIS). Age and Ageing, v. 53, n. 3, afae052, 2024.',\n    doi: '10.1093/ageing/afae052',\n    key: 'glis-2024',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/38520141/',\n  },\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Ácidos graxos ômega\n  // ---------------------------------------------------------------------------\n  'harris-omega3-2004': {\n    abnt: 'HARRIS, W. S.; VON SCHACKY, C. The Omega-3 Index: a new risk factor for death from coronary heart disease? Preventive Medicine, v. 39, n. 1, p. 212-220, 2004.',\n    doi: '10.1016/j.ypmed.2004.02.030',\n    key: 'harris-omega3-2004',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/15208005/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Referência laboratorial geral\n  // ---------------------------------------------------------------------------\n  'kalaria-ck-ri-2026': {\n    abnt: 'KALARIA, T. et al. Age, sex and ethnicity changes in creatine kinase and sex- and ethnicity-specific reference intervals of creatine kinase. Clinical Medicine, v. 26, n. 4, p. 100596, 2026.',\n    doi: '10.1016/j.clinme.2026.100596',\n    key: 'kalaria-ck-ri-2026',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/42142664/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Nefrologia\n  // ---------------------------------------------------------------------------\n  'kdigo-ckd-2024': {\n    abnt: 'KIDNEY DISEASE: IMPROVING GLOBAL OUTCOMES (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International, v. 105, n. 4S, p. S117-S314, 2024.',\n    doi: '10.1016/j.kint.2023.10.018',\n    key: 'kdigo-ckd-2024',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/38490803/',\n  },\n\n  'keller-tni-2013': {\n    abnt: 'KELLER, T. et al. Defining a reference population to determine the 99th percentile of a contemporary sensitive cardiac troponin I assay. International Journal of Cardiology, v. 167, n. 4, p. 1423-1429, 2013.',\n    doi: '10.1016/j.ijcard.2012.04.063',\n    key: 'keller-tni-2013',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/22560907/',\n  },\n\n  'kelly-dxa-2009': {\n    abnt: 'KELLY, T. L. et al. Dual energy X-ray absorptiometry body composition reference values from NHANES. PLoS One, v. 4, n. 9, e7038, 2009.',\n    doi: '10.1371/journal.pone.0007038',\n    key: 'kelly-dxa-2009',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19753111/',\n  },\n\n  'khetarpal-apociii-2016': {\n    abnt: 'KHETARPAL, S. A. et al. Why is apolipoprotein CIII emerging as a novel therapeutic target to reduce the burden of cardiovascular disease? Current Atherosclerosis Reports, v. 18, n. 10, p. 59, 2016.',\n    key: 'khetarpal-apociii-2016',\n    url: 'https://pmc.ncbi.nlm.nih.gov/articles/PMC5018018/',\n  },\n\n  'klee-bhb-2020': {\n    abnt: 'KLEE, P. et al. Test validation, method comparison and reference range for the measurement of β-hydroxybutyrate in peripheral blood samples. Practical Laboratory Medicine, v. 18, e00146, 2020.',\n    doi: '10.1016/j.plabm.2019.e00146',\n    key: 'klee-bhb-2020',\n    url: 'https://pmc.ncbi.nlm.nih.gov/articles/PMC6999181/',\n  },\n\n  'maisel-bnp-2002': {\n    abnt: 'MAISEL, A. S. et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. New England Journal of Medicine, v. 347, n. 3, p. 161-167, 2002.',\n    doi: '10.1056/NEJMoa020233',\n    key: 'maisel-bnp-2002',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/12124404/',\n  },\n\n  'meuwese-mpo-2007': {\n    abnt: 'MEUWESE, M. C. et al. Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study. Journal of the American College of Cardiology, v. 50, n. 2, p. 159-165, 2007.',\n    doi: '10.1016/j.jacc.2007.03.033',\n    key: 'meuwese-mpo-2007',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/17616301/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Marcadores metabólicos e inflamatórios\n  // ---------------------------------------------------------------------------\n  'nemeth-adma-2017': {\n    abnt: 'NEMETH, B. et al. The issue of plasma asymmetric dimethylarginine reference range: a systematic review and meta-analysis. PLoS One, v. 12, n. 5, e0177493, 2017.',\n    doi: '10.1371/journal.pone.0177493',\n    key: 'nemeth-adma-2017',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/28494019/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes brasileiras — Metais pesados (NR-7)\n  // ---------------------------------------------------------------------------\n  'nr7-pcmso-2020': {\n    abnt: 'BRASIL. Ministério do Trabalho e Emprego. NR-7 — PCMSO, Quadro 1: Indicadores biológicos. Portaria n. 6.734, de 9 de março de 2020. Diário Oficial da União, Brasília, 13 mar. 2020.',\n    key: 'nr7-pcmso-2020',\n    url: 'https://www.gov.br/trabalho-e-emprego/pt-br/assuntos/inspecao-do-trabalho/seguranca-e-saude-no-trabalho/sst-portarias/2022/portaria-no-567-de-10-de-marco-de-2022-alteracoes-na-nr-7.pdf',\n  },\n\n  'ofenheimer-vat-2020': {\n    abnt: 'OFENHEIMER, A. et al. Reference values of body composition parameters and visceral adipose tissue (VAT) by DXA in adults aged 18-81 years: results from the LEAD cohort. European Journal of Clinical Nutrition, v. 74, p. 1181-1191, 2020.',\n    doi: '10.1038/s41430-020-0596-5',\n    key: 'ofenheimer-vat-2020',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/32123345/',\n  },\n\n  'pns-bioquimica-2019': {\n    abnt: 'SZWARCWALD, C. L. et al. Valores de referência para exames laboratoriais de colesterol, hemoglobina glicosilada e creatinina da população adulta brasileira. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190002.supl.2, 2019.',\n    doi: '10.1590/1980-549720190002.supl.2',\n    key: 'pns-bioquimica-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/31596373/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Pesquisa Nacional de Saúde (PNS) — Intervalos de referência brasileiros\n  // ---------------------------------------------------------------------------\n  'pns-hemograma-2019': {\n    abnt: 'ROSENFELD, L. G. et al. Valores de referência para exames laboratoriais de hemograma da população adulta brasileira: Pesquisa Nacional de Saúde. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190003.supl.2, 2019.',\n    doi: '10.1590/1980-549720190003.supl.2',\n    key: 'pns-hemograma-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/31596374/',\n  },\n\n  'pns-renal-2019': {\n    abnt: 'MALTA, D. C. et al. Evaluation of renal function in the Brazilian adult population, according to laboratory criteria from the National Health Survey. Revista Brasileira de Epidemiologia, v. 22, supl. 2, e190010.supl.2, 2019.',\n    doi: '10.1590/1980-549720190010.supl.2',\n    key: 'pns-renal-2019',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/31596381/',\n  },\n\n  'rumberger-cac-1999': {\n    abnt: 'RUMBERGER, J. A. et al. Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons. Mayo Clinic Proceedings, v. 74, n. 3, p. 243-252, 1999.',\n    doi: '10.4065/74.3.243',\n    key: 'rumberger-cac-1999',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/10089993/',\n  },\n\n  'sbc-ic-2018': {\n    abnt: 'ROHDE, L. E. P. et al. Diretriz Brasileira de Insuficiência Cardíaca Crônica e Aguda. Arquivos Brasileiros de Cardiologia, São Paulo, v. 111, n. 3, p. 436-539, set. 2018.',\n    doi: '10.5935/abc.20180190',\n    key: 'sbc-ic-2018',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/30379264/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Cardiologia\n  // ---------------------------------------------------------------------------\n  'sbc-lipids-2017': {\n    abnt: 'FALUDI, A. A. et al. Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose – 2017. Arquivos Brasileiros de Cardiologia, São Paulo, v. 109, n. 2, supl. 1, p. 1-76, ago. 2017.',\n    doi: '10.5935/abc.20170121',\n    key: 'sbc-lipids-2017',\n    url: 'https://www.scielo.br/j/abc/a/whBsCyzTDzGYJcsBY7YVkWn/?lang=pt',\n  },\n\n  'sbc-lipids-2025': {\n    abnt: 'RACHED, F. H. et al. Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose – 2025. Arquivos Brasileiros de Cardiologia, São Paulo, v. 122, n. 9, e20250640, out. 2025.',\n    doi: '10.36660/abc.20250640',\n    key: 'sbc-lipids-2025',\n    url: 'https://pmc.ncbi.nlm.nih.gov/articles/PMC12674852/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Diabetes\n  // ---------------------------------------------------------------------------\n  'sbd-diabetes-2024': {\n    // Chave mantida como 'sbd-diabetes-2024' para compatibilidade com\n    // consumidores publicados; a diretriz correspondente é o documento vivo\n    // de diretriz.diabetes.org.br, cuja edição citada quando este registro foi\n    // atualizado é \"Edição 2025\". Semelhante ao caso de sbpc-ml-2021 abaixo.\n    abnt: 'SOCIEDADE BRASILEIRA DE DIABETES (SBD). Diretriz da Sociedade Brasileira de Diabetes — Edição 2025. São Paulo: SBD, 2025.',\n    doi: '10.29327/5660187',\n    isbn: '978-65-272-1932-3',\n    key: 'sbd-diabetes-2024',\n    url: 'https://diretriz.diabetes.org.br',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Endocrinologia e Metabologia\n  // ---------------------------------------------------------------------------\n  'sbem-thyroid-2013': {\n    abnt: 'SGARBI, J. A. et al. Consenso brasileiro para a abordagem clínica e tratamento do hipotireoidismo subclínico em adultos. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 57, n. 3, p. 166-183, 2013.',\n    doi: '10.1590/S0004-27302013000300003',\n    key: 'sbem-thyroid-2013',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/23681263/',\n  },\n  'sbem-vitamind-2014': {\n    abnt: 'MAEDA, S. S. et al. Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 58, n. 5, p. 411-433, 2014.',\n    doi: '10.1590/0004-2730000003388',\n    key: 'sbem-vitamind-2014',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/25166032/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Sociedade Brasileira de Patologia Clínica / Medicina Laboratorial\n  // ---------------------------------------------------------------------------\n  'sbpc-ml-2021': {\n    // Chave mantida como 'sbpc-ml-2021' para compatibilidade com consumidores;\n    // a edição autoritativa é de 2020 (verificada na Biblioteca Digital SBPC/ML\n    // em 2026-04-18). Ano na citação ABNT reflete a edição real.\n    abnt: 'SOCIEDADE BRASILEIRA DE PATOLOGIA CLÍNICA/MEDICINA LABORATORIAL (SBPC/ML). Recomendações da Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial (SBPC/ML): Boas Práticas em Laboratório Clínico. São Paulo: SBPC/ML, 2020.',\n    key: 'sbpc-ml-2021',\n    url: 'https://bibliotecasbpc.org.br/index.php?P=4&C=0.2.443',\n  },\n\n  'schumann-ifcc-ldh-2002': {\n    abnt: 'SCHUMANN, G.; KLAUKE, R. New IFCC reference procedures for the determination of catalytic activity concentrations of five enzymes in serum: preliminary upper reference limits obtained in hospitalized subjects. Clinica Chimica Acta, v. 327, n. 1-2, p. 69-79, 2003.',\n    doi: '10.1016/S0009-8981(02)00341-8',\n    key: 'schumann-ifcc-ldh-2002',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/12482620/',\n  },\n\n  'schwedhelm-sdma-2011': {\n    abnt: 'SCHWEDHELM, E. et al. Plasma symmetric dimethylarginine reference limits from the Framingham Offspring Cohort. Clinical Chemistry and Laboratory Medicine, v. 49, n. 11, p. 1907-1910, 2011.',\n    doi: '10.1515/CCLM.2011.679',\n    key: 'schwedhelm-sdma-2011',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/21864208/',\n  },\n\n  'selhub-homocysteine-1999': {\n    abnt: 'SELHUB, J. et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Annals of Internal Medicine, v. 131, n. 5, p. 331-339, 1999.',\n    doi: '10.7326/0003-4819-131-5-199909070-00003',\n    key: 'selhub-homocysteine-1999',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/10475885/',\n  },\n\n  'simopoulos-omega-ratio-2002': {\n    abnt: 'SIMOPOULOS, A. P. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy, v. 56, n. 8, p. 365-379, 2002.',\n    doi: '10.1016/S0753-3322(02)00253-6',\n    key: 'simopoulos-omega-ratio-2002',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/12442909/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Marcadores tumorais\n  // ---------------------------------------------------------------------------\n  'sturgeon-nacb-2008': {\n    abnt: 'STURGEON, C. M. et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers. Clinical Chemistry, v. 54, n. 12, p. e11-e79, 2008.',\n    doi: '10.1373/clinchem.2008.105601',\n    key: 'sturgeon-nacb-2008',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/19042984/',\n  },\n\n  'tietz-7ed-2015': {\n    abnt: 'BURTIS, C. A.; BRUNS, D. E. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. 7. ed. St. Louis: Elsevier Saunders, 2015.',\n    isbn: '978-1-4557-4165-6',\n    key: 'tietz-7ed-2015',\n  },\n\n  'torrissen-omega3-dbs-2025': {\n    abnt: 'TORRISSEN, M. et al. Global variations in omega-3 fatty acid status and omega-6:omega-3 ratios: insights from > 500,000 whole-blood dried blood spot samples. Lipids in Health and Disease, v. 24, n. 1, p. 260, 2025.',\n    doi: '10.1186/s12944-025-02676-6',\n    key: 'torrissen-omega3-dbs-2025',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/40783537/',\n  },\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — Coagulação\n  // ---------------------------------------------------------------------------\n  'wells-ddimer-2003': {\n    abnt: 'WELLS, P. S. et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. New England Journal of Medicine, v. 349, p. 1227-1235, 2003.',\n    doi: '10.1056/NEJMoa023153',\n    key: 'wells-ddimer-2003',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/14507948/',\n  },\n\n  // ---------------------------------------------------------------------------\n  // Fontes internacionais — OMS\n  // ---------------------------------------------------------------------------\n  'who-iron-2020': {\n    abnt: 'WORLD HEALTH ORGANIZATION. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. Geneva: WHO, 2020.',\n    isbn: '978-92-4-000012-4',\n    key: 'who-iron-2020',\n    url: 'https://www.who.int/publications/i/item/9789240000124',\n  },\n\n  'who-obesity-2000': {\n    abnt: 'WORLD HEALTH ORGANIZATION. Obesity: preventing and managing the global epidemic. WHO Technical Report Series, n. 894. Geneva: WHO, 2000.',\n    isbn: '92-4-120894-5',\n    key: 'who-obesity-2000',\n  },\n\n  'who-osteoporosis-1994': {\n    abnt: 'WHO STUDY GROUP. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report Series, n. 843. Geneva: WHO, 1994.',\n    key: 'who-osteoporosis-1994',\n    url: 'https://pubmed.ncbi.nlm.nih.gov/7941614/',\n  },\n};\n\n/**\n * Extrai a chave de fonte de um valor `source` que pode conter localizador.\n *\n * @example\n * extractSourceKey('sbc-lipids-2017:p15') // 'sbc-lipids-2017'\n * extractSourceKey('sbpc-ml-2021')        // 'sbpc-ml-2021'\n */\nexport function extractSourceKey(source: string): string {\n  return source.split(':')[0] ?? source;\n}\n"]}