@precisa-saude/fhir 0.1.0

package/dist/chunk-2X6MT5KE.cjs

@@ -0,0 +1,1464 @@
+"use strict";Object.defineProperty(exports, "__esModule", {value: true}); function _nullishCoalesce(lhs, rhsFn) { if (lhs != null) { return lhs; } else { return rhsFn(); } } function _optionalChain(ops) { let lastAccessLHS = undefined; let value = ops[0]; let i = 1; while (i < ops.length) { const op = ops[i]; const fn = ops[i + 1]; i += 2; if ((op === 'optionalAccess' || op === 'optionalCall') && value == null) { return undefined; } if (op === 'access' || op === 'optionalAccess') { lastAccessLHS = value; value = fn(value); } else if (op === 'call' || op === 'optionalCall') { value = fn((...args) => value.call(lastAccessLHS, ...args)); lastAccessLHS = undefined; } } return value; }
+
+var _chunkGFXKYXHWcjs = require('./chunk-GFXKYXHW.cjs');
+
+// src/reference-ranges.ts
+var biomarkerRangeDefinitions = {
+  // =============================================================================
+  // LIPIDS
+  // =============================================================================
+  Albumin_Creatinine_Ratio: {
+    default: { max: 30, min: 0, optimalMax: 20, optimalMin: 0, unit: "mg/g" }
+  },
+  Adiponectin: {
+    default: { max: 26, min: 4, optimalMax: 20, optimalMin: 8, unit: "mcg/mL" }
+  },
+  ADMA: {
+    default: { max: 0.7, min: 0.3, optimalMax: 0.55, optimalMin: 0.3, unit: "umol/L" }
+  },
+  AFP: {
+    default: { max: 10, min: 0, optimalMax: 8, optimalMin: 0, unit: "ng/mL" }
+  },
+  Albumin_Globulin_Ratio: {
+    default: { max: 2.5, min: 1, optimalMax: 2.2, optimalMin: 1.2, unit: "" }
+  },
+  Albumin: {
+    default: { max: 5, min: 3.5, optimalMax: 4.8, optimalMin: 4, unit: "g/dL" },
+    source: "sbpc-ml-2021"
+  },
+  AlkalinePhosphatase: {
+    default: { max: 147, min: 44, optimalMax: 120, optimalMin: 50, unit: "U/L" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 147, min: 44, optimalMax: 120, optimalMin: 50, unit: "U/L" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 104, min: 35, optimalMax: 90, optimalMin: 40, unit: "U/L" },
+        sex: "F"
+      }
+    ]
+  },
+  ALT: {
+    default: { max: 35, min: 0, optimalMax: 25, optimalMin: 0, unit: "U/L" },
+    source: "sbpc-ml-2021",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 56, min: 7, optimalMax: 35, optimalMin: 10, unit: "U/L" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 45, min: 7, optimalMax: 30, optimalMin: 10, unit: "U/L" },
+        sex: "F"
+      }
+    ]
+  },
+  AMH: {
+    default: { max: 10, min: 1, optimalMax: 6.9, optimalMin: 2, unit: "ng/mL" },
+    variants: [
+      {
+        ageMax: 24,
+        ageMin: 18,
+        range: { max: 13, min: 1.5, optimalMax: 10, optimalMin: 3, unit: "ng/mL" },
+        sex: "F"
+      },
+      {
+        ageMax: 30,
+        ageMin: 25,
+        range: { max: 10, min: 1.5, optimalMax: 8, optimalMin: 2.5, unit: "ng/mL" },
+        sex: "F"
+      },
+      {
+        ageMax: 35,
+        ageMin: 31,
+        range: { max: 8, min: 1, optimalMax: 6, optimalMin: 2, unit: "ng/mL" },
+        sex: "F"
+      },
+      {
+        ageMax: 40,
+        ageMin: 36,
+        range: { max: 6, min: 0.5, optimalMax: 4, optimalMin: 1, unit: "ng/mL" },
+        sex: "F"
+      },
+      {
+        ageMin: 41,
+        range: { max: 3, min: 0.1, optimalMax: 2, optimalMin: 0.5, unit: "ng/mL" },
+        sex: "F"
+      }
+    ]
+  },
+  Ammonia: {
+    default: { max: 45, min: 15, optimalMax: 40, optimalMin: 20, unit: "umol/L" }
+  },
+  AntiThyroglobulin: {
+    default: { max: 115, min: 0, optimalMax: 40, optimalMin: 0, unit: "IU/mL" }
+  },
+  AntiTPO: {
+    default: { max: 34, min: 0, optimalMax: 9, optimalMin: 0, unit: "IU/mL" }
+  },
+  // Aortic valve calcium — no standardized clinical threshold; use mild cutoff
+  AorticValveCalcium: {
+    default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
+    direction: "lower-better"
+  },
+  ApoA1: {
+    default: { max: 200, min: 100, optimalMax: 180, optimalMin: 120, unit: "mg/dL" }
+  },
+  ApoB: {
+    default: { max: 90, min: 0, optimalMax: 70, optimalMin: 0, unit: "mg/dL" },
+    direction: "lower-better"
+  },
+  ApoCIII: {
+    default: { max: 10, min: 0, optimalMax: 7, optimalMin: 0, unit: "mg/dL" }
+  },
+  ApoCIII_ApoA1_Ratio: {
+    default: { max: 0.15, min: 0, optimalMax: 0.1, optimalMin: 0, unit: "" }
+  },
+  // =============================================================================
+  // THYROID
+  // =============================================================================
+  Omega6_AA: {
+    default: { max: 15, min: 5, optimalMax: 12, optimalMin: 7, unit: "%" }
+  },
+  AA_EPA_Ratio: {
+    default: { max: 15, min: 1, optimalMax: 5, optimalMin: 1.5, unit: "" },
+    direction: "lower-better"
+  },
+  Arsenic: {
+    default: { max: 35, min: 0, optimalMax: 20, optimalMin: 0, unit: "mcg/L" }
+  },
+  AST: {
+    default: { max: 35, min: 0, optimalMax: 25, optimalMin: 0, unit: "U/L" },
+    source: "sbpc-ml-2021",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 40, min: 10, optimalMax: 30, optimalMin: 10, unit: "U/L" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 32, min: 9, optimalMax: 25, optimalMin: 10, unit: "U/L" },
+        sex: "F"
+      }
+    ]
+  },
+  Basophils: {
+    default: { max: 1, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "%" }
+  },
+  Basophils_Abs: {
+    default: { max: 0.1, min: 0, optimalMax: 0.05, optimalMin: 0, unit: "K/uL" }
+  },
+  // =============================================================================
+  // HEMATOLOGY - CBC
+  // =============================================================================
+  Bicarbonate: {
+    default: { max: 29, min: 23, optimalMax: 28, optimalMin: 24, unit: "mEq/L" }
+  },
+  BilirubinDirect: {
+    default: { max: 0.3, min: 0, optimalMax: 0.2, optimalMin: 0, unit: "mg/dL" }
+  },
+  BilirubinIndirect: {
+    default: { max: 0.8, min: 0, optimalMax: 0.6, optimalMin: 0, unit: "mg/dL" }
+  },
+  BilirubinTotal: {
+    default: { max: 1.2, min: 0.1, optimalMax: 0.9, optimalMin: 0.2, unit: "mg/dL" }
+  },
+  BNP: {
+    default: { max: 100, min: 0, optimalMax: 50, optimalMin: 0, unit: "pg/mL" }
+  },
+  BUN_Creatinine_Ratio: {
+    default: { max: 20, min: 10, optimalMax: 18, optimalMin: 12, unit: "" }
+  },
+  CA125: {
+    default: { max: 35, min: 0, optimalMax: 25, optimalMin: 0, unit: "U/mL" }
+  },
+  CA199: {
+    default: { max: 37, min: 0, optimalMax: 30, optimalMin: 0, unit: "U/mL" }
+  },
+  // CAC: Agatston classification — 0=none, 1-99=mild, 100-399=moderate, 400+=severe
+  // max=99 so only moderate+ scores (≥100) flag as ANORMAL; optimalMax=0 (zero is ideal)
+  CAC: {
+    default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
+    direction: "lower-better"
+  },
+  // Per-vessel scores (hidden) — no standardized thresholds, use same mild cutoff
+  CAC_LAD: {
+    default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
+    direction: "lower-better"
+  },
+  CAC_LCX: {
+    default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
+    direction: "lower-better"
+  },
+  CAC_LMA: {
+    default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
+    direction: "lower-better"
+  },
+  CAC_Percentile: {
+    default: { max: 50, min: 0, optimalMax: 25, optimalMin: 0, unit: "%", warningMax: 75 },
+    direction: "lower-better"
+  },
+  CAC_RCA: {
+    default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
+    direction: "lower-better"
+  },
+  Cadmium: {
+    default: { max: 1.2, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "mcg/L" }
+  },
+  Calcium: {
+    default: { max: 10.5, min: 8.5, optimalMax: 10, optimalMin: 9, unit: "mg/dL" }
+  },
+  CEA: {
+    default: { max: 3, min: 0, optimalMax: 2.5, optimalMin: 0, unit: "ng/mL" }
+  },
+  CK: {
+    default: { max: 190, min: 30, optimalMax: 170, optimalMin: 40, unit: "U/L" },
+    variants: [
+      { sex: "F", range: { max: 170, min: 30, optimalMax: 150, optimalMin: 40, unit: "U/L" } }
+    ]
+  },
+  Chloride: {
+    default: { max: 106, min: 98, optimalMax: 105, optimalMin: 100, unit: "mEq/L" }
+  },
+  Cholesterol: {
+    default: { max: 200, min: 0, optimalMax: 180, optimalMin: 0, unit: "mg/dL" },
+    source: "sbc-lipids-2017"
+  },
+  Cholesterol_HDL_Ratio: {
+    // Lower is better - Function Health reference: <= 3.5
+    default: { max: 5, min: 0, optimalMax: 3.5, optimalMin: 0, unit: "" },
+    direction: "lower-better",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 5, min: 0, optimalMax: 4, optimalMin: 0, unit: "" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 4.5, min: 0, optimalMax: 3.5, optimalMin: 0, unit: "" },
+        sex: "F"
+      }
+    ]
+  },
+  CO2: {
+    default: { max: 29, min: 23, optimalMax: 28, optimalMin: 24, unit: "mEq/L" }
+  },
+  Copper: {
+    default: { max: 175, min: 70, optimalMax: 150, optimalMin: 85, unit: "mcg/dL" }
+  },
+  CoQ10: {
+    default: { max: 1.5, min: 0.5, optimalMax: 1.3, optimalMin: 0.7, unit: "mg/L" }
+  },
+  Cortisol: {
+    default: { max: 25, min: 5, optimalMax: 20, optimalMin: 10, unit: "mcg/dL" }
+  },
+  CortisolFree: {
+    default: { max: 2.5, min: 0.5, optimalMax: 2, optimalMin: 0.8, unit: "mcg/dL" }
+  },
+  CPeptide: {
+    default: { max: 3.9, min: 0.8, optimalMax: 3, optimalMin: 1, unit: "ng/mL" }
+  },
+  Creatinine: {
+    default: { max: 1.2, min: 0.6, optimalMax: 1, optimalMin: 0.7, unit: "mg/dL" },
+    source: "sbpc-ml-2021",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 1.3, min: 0.7, optimalMax: 1.1, optimalMin: 0.8, unit: "mg/dL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 1.1, min: 0.5, optimalMax: 0.9, optimalMin: 0.6, unit: "mg/dL" },
+        sex: "F"
+      }
+    ]
+  },
+  CRP: {
+    default: { max: 3, min: 0, optimalMax: 1, optimalMin: 0, unit: "mg/L" },
+    direction: "lower-better"
+  },
+  CystatinC: {
+    default: { max: 1, min: 0.5, optimalMax: 0.9, optimalMin: 0.6, unit: "mg/L" }
+  },
+  DDimer: {
+    default: { max: 500, min: 0, optimalMax: 250, optimalMin: 0, unit: "ng/mL" }
+  },
+  // =============================================================================
+  // METABOLIC PANEL
+  // =============================================================================
+  Omega3_DHA: {
+    default: { max: 8, min: 2, optimalMax: 6.5, optimalMin: 3.5, unit: "%" }
+  },
+  DHEAS: {
+    default: { max: 500, min: 100, optimalMax: 400, optimalMin: 150, unit: "mcg/dL" },
+    variants: [
+      {
+        ageMax: 39,
+        ageMin: 18,
+        range: { max: 640, min: 280, optimalMax: 500, optimalMin: 300, unit: "mcg/dL" },
+        sex: "M"
+      },
+      {
+        ageMax: 59,
+        ageMin: 40,
+        range: { max: 520, min: 120, optimalMax: 400, optimalMin: 150, unit: "mcg/dL" },
+        sex: "M"
+      },
+      {
+        ageMin: 60,
+        range: { max: 290, min: 42, optimalMax: 220, optimalMin: 80, unit: "mcg/dL" },
+        sex: "M"
+      },
+      {
+        ageMax: 39,
+        ageMin: 18,
+        range: { max: 380, min: 65, optimalMax: 300, optimalMin: 100, unit: "mcg/dL" },
+        sex: "F"
+      },
+      {
+        ageMax: 59,
+        ageMin: 40,
+        range: { max: 240, min: 32, optimalMax: 180, optimalMin: 60, unit: "mcg/dL" },
+        sex: "F"
+      },
+      {
+        ageMin: 60,
+        range: { max: 140, min: 18, optimalMax: 100, optimalMin: 30, unit: "mcg/dL" },
+        sex: "F"
+      }
+    ]
+  },
+  Omega3_DPA: {
+    default: { max: 2, min: 0.3, optimalMax: 1.5, optimalMin: 0.5, unit: "%" }
+  },
+  eGFR: {
+    default: { max: 120, min: 90, optimalMax: 120, optimalMin: 90, unit: "mL/min/1.73m\xB2" },
+    variants: [
+      {
+        ageMin: 60,
+        range: { max: 90, min: 60, optimalMax: 90, optimalMin: 60, unit: "mL/min/1.73m\xB2" },
+        sex: "all"
+      }
+    ]
+  },
+  Eosinophils: {
+    default: { max: 5, min: 0, optimalMax: 4, optimalMin: 1, unit: "%" },
+    direction: "lower-better"
+  },
+  Eosinophils_Abs: {
+    default: { max: 0.5, min: 0, optimalMax: 0.3, optimalMin: 0, unit: "K/uL" }
+  },
+  Omega3_EPA: {
+    default: { max: 3.5, min: 0.5, optimalMax: 2.5, optimalMin: 1, unit: "%" }
+  },
+  EPADPADHA: {
+    default: { max: 10, min: 3, optimalMax: 9, optimalMin: 5, unit: "%" }
+  },
+  ESR: {
+    default: { max: 20, min: 0, optimalMax: 10, optimalMin: 0, unit: "mm/hr" }
+  },
+  Estradiol: {
+    default: { max: 40, min: 10, optimalMax: 35, optimalMin: 15, unit: "pg/mL" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 40, min: 10, optimalMax: 30, optimalMin: 15, unit: "pg/mL" },
+        sex: "M"
+      },
+      {
+        ageMax: 50,
+        ageMin: 18,
+        range: { max: 400, min: 30, optimalMax: 300, optimalMin: 50, unit: "pg/mL" },
+        sex: "F"
+      },
+      {
+        ageMin: 51,
+        range: { max: 30, min: 0, optimalMax: 20, optimalMin: 0, unit: "pg/mL" },
+        sex: "F"
+      }
+    ]
+  },
+  F2Isoprostanes: {
+    default: { max: 86, min: 0, optimalMax: 60, optimalMin: 0, unit: "pg/mL" }
+  },
+  Ferritin: {
+    default: { max: 300, min: 20, optimalMax: 150, optimalMin: 50, unit: "ng/mL" },
+    source: "sbpc-ml-2021",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 400, min: 30, optimalMax: 200, optimalMin: 50, unit: "ng/mL" },
+        sex: "M"
+      },
+      {
+        ageMax: 50,
+        ageMin: 18,
+        range: { max: 150, min: 15, optimalMax: 100, optimalMin: 30, unit: "ng/mL" },
+        sex: "F"
+      },
+      {
+        ageMin: 51,
+        range: { max: 300, min: 30, optimalMax: 150, optimalMin: 50, unit: "ng/mL" },
+        sex: "F"
+      }
+    ]
+  },
+  Fibrinogen: {
+    default: { max: 400, min: 200, optimalMax: 350, optimalMin: 250, unit: "mg/dL" }
+  },
+  FolicAcid: {
+    default: { max: 20, min: 3, optimalMax: 15, optimalMin: 5, unit: "ng/mL" }
+  },
+  // =============================================================================
+  // LIVER FUNCTION
+  // =============================================================================
+  FSH: {
+    default: { max: 12.4, min: 1.5, optimalMax: 10, optimalMin: 3, unit: "mIU/mL" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 12.4, min: 1.5, optimalMax: 8, optimalMin: 1.5, unit: "mIU/mL" },
+        sex: "M"
+      },
+      {
+        ageMax: 50,
+        ageMin: 18,
+        range: { max: 12.5, min: 3.5, optimalMax: 10, optimalMin: 3.5, unit: "mIU/mL" },
+        sex: "F"
+      },
+      {
+        ageMin: 51,
+        range: { max: 134.8, min: 25.8, optimalMax: 80, optimalMin: 25.8, unit: "mIU/mL" },
+        sex: "F"
+      }
+    ]
+  },
+  GGT: {
+    default: { max: 55, min: 0, optimalMax: 30, optimalMin: 0, unit: "U/L" },
+    direction: "lower-better",
+    source: "sbpc-ml-2021",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 61, min: 8, optimalMax: 40, optimalMin: 10, unit: "U/L" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 36, min: 5, optimalMax: 25, optimalMin: 8, unit: "U/L" },
+        sex: "F"
+      }
+    ]
+  },
+  Ghrelin: {
+    default: { max: 1e3, min: 300, optimalMax: 800, optimalMin: 400, unit: "pg/mL" }
+  },
+  Globulin: {
+    default: { max: 3.5, min: 2, optimalMax: 3.2, optimalMin: 2.3, unit: "g/dL" }
+  },
+  Glucose: {
+    default: { max: 100, min: 70, optimalMax: 90, optimalMin: 70, unit: "mg/dL" },
+    source: "sbd-diabetes-2024"
+  },
+  GlycoMark: {
+    default: { max: 40, min: 10, optimalMax: 35, optimalMin: 15, unit: "mcg/mL" }
+  },
+  GrowthHormone: {
+    default: { max: 5, min: 0, optimalMax: 3, optimalMin: 0, unit: "ng/mL" }
+  },
+  HbA1c: {
+    default: { max: 5.7, min: 4, optimalMax: 5.3, optimalMin: 4.5, unit: "%" },
+    source: "sbd-diabetes-2024"
+  },
+  Hct: {
+    default: { max: 50, min: 36, optimalMax: 48, optimalMin: 40, unit: "%" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 54, min: 40, optimalMax: 50, optimalMin: 42, unit: "%" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 48, min: 36, optimalMax: 45, optimalMin: 38, unit: "%" },
+        sex: "F"
+      }
+    ]
+  },
+  HDL: {
+    default: { max: 60, min: 40, optimalMax: 60, optimalMin: 50, unit: "mg/dL" },
+    direction: "higher-better",
+    source: "sbc-lipids-2017",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 60, min: 40, optimalMax: 60, optimalMin: 45, unit: "mg/dL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 60, min: 50, optimalMax: 60, optimalMin: 55, unit: "mg/dL" },
+        sex: "F"
+      }
+    ]
+  },
+  HDL_Large: {
+    // HDL Large: higher is better
+    // Quest Ion Mobility reference: Male 4334-10815, Female 5038-17886 nmol/L, optimal >6729
+    default: { max: 17886, min: 4334, optimalMax: 17886, optimalMin: 6729, unit: "nmol/L" },
+    direction: "higher-better"
+  },
+  // =============================================================================
+  // INFLAMMATION
+  // =============================================================================
+  Hgb: {
+    default: { max: 17.5, min: 12, optimalMax: 16, optimalMin: 13.5, unit: "g/dL" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 17.5, min: 13.5, optimalMax: 16.5, optimalMin: 14, unit: "g/dL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 15.5, min: 12, optimalMax: 14.5, optimalMin: 12.5, unit: "g/dL" },
+        sex: "F"
+      }
+    ]
+  },
+  HOMA_IR: {
+    default: { max: 2.5, min: 0, optimalMax: 1.5, optimalMin: 0, unit: "" },
+    direction: "lower-better"
+  },
+  Homocysteine: {
+    default: { max: 15, min: 4, optimalMax: 10, optimalMin: 5, unit: "umol/L" },
+    direction: "lower-better"
+  },
+  IGF1: {
+    default: { max: 350, min: 100, optimalMax: 300, optimalMin: 150, unit: "ng/mL" }
+  },
+  // =============================================================================
+  // METABOLIC
+  // =============================================================================
+  ImmatureGranulocytes: {
+    default: { max: 1, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "%" }
+  },
+  Insulin: {
+    default: { max: 25, min: 2, optimalMax: 8, optimalMin: 3, unit: "\xB5IU/mL" }
+  },
+  Iron: {
+    default: { max: 170, min: 60, optimalMax: 140, optimalMin: 80, unit: "mcg/dL" },
+    source: "sbpc-ml-2021",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 175, min: 65, optimalMax: 150, optimalMin: 80, unit: "mcg/dL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 170, min: 50, optimalMax: 130, optimalMin: 60, unit: "mcg/dL" },
+        sex: "F"
+      }
+    ]
+  },
+  Lactate: {
+    default: { max: 2.2, min: 0.5, optimalMax: 1.8, optimalMin: 0.7, unit: "mmol/L" }
+  },
+  LDL: {
+    default: { max: 100, min: 0, optimalMax: 70, optimalMin: 0, unit: "mg/dL" },
+    direction: "lower-better",
+    source: "sbc-lipids-2017"
+  },
+  LDL_Medium: {
+    // LDL Medium (LDL Média): lower is better
+    // Quest Ion Mobility reference: Male 167-485, Female 121-397 nmol/L, optimal <215
+    default: { max: 485, min: 121, optimalMax: 215, optimalMin: 121, unit: "nmol/L" },
+    direction: "lower-better"
+  },
+  LDL_ParticleNumber: {
+    // LDL Particle Number: lower is better
+    // Quest Ion Mobility reference: 1016-2185 nmol/L, optimal <1138
+    default: { max: 2185, min: 1016, optimalMax: 1138, optimalMin: 1016, unit: "nmol/L" },
+    direction: "lower-better"
+  },
+  LDL_Peak_Size: {
+    // LDL Peak Size: higher is better (larger particles less atherogenic)
+    // Quest Ion Mobility reference: optimal >222.9 Å (22.29 nm)
+    default: { max: 250, min: 217.4, optimalMax: 250, optimalMin: 222.9, unit: "\xC5" },
+    direction: "higher-better"
+  },
+  // =============================================================================
+  // IRON STUDIES
+  // =============================================================================
+  LDL_Small: {
+    // LDL Small (LDL Pequena): lower is better (small dense LDL is most atherogenic)
+    // Quest Ion Mobility reference: Male 123-441, Female 126-382 nmol/L, optimal <142
+    default: { max: 441, min: 123, optimalMax: 142, optimalMin: 123, unit: "nmol/L" },
+    direction: "lower-better"
+  },
+  Lead: {
+    default: { max: 5, min: 0, optimalMax: 2, optimalMin: 0, unit: "mcg/dL" }
+  },
+  Leptin: {
+    default: { max: 15, min: 2, optimalMax: 12, optimalMin: 3, unit: "ng/mL" },
+    direction: "lower-better",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 10, min: 1, optimalMax: 8, optimalMin: 2, unit: "ng/mL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 25, min: 4, optimalMax: 18, optimalMin: 5, unit: "ng/mL" },
+        sex: "F"
+      }
+    ]
+  },
+  LH: {
+    default: { max: 8.6, min: 1.7, optimalMax: 8, optimalMin: 2, unit: "mIU/mL" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 8.6, min: 1.7, optimalMax: 6, optimalMin: 1.7, unit: "mIU/mL" },
+        sex: "M"
+      },
+      {
+        ageMax: 50,
+        ageMin: 18,
+        range: { max: 12.6, min: 2.4, optimalMax: 10, optimalMin: 2.4, unit: "mIU/mL" },
+        sex: "F"
+      },
+      {
+        ageMin: 51,
+        range: { max: 58.5, min: 7.7, optimalMax: 40, optimalMin: 10, unit: "mIU/mL" },
+        sex: "F"
+      }
+    ]
+  },
+  Omega6_LA: {
+    default: { max: 35, min: 15, optimalMax: 28, optimalMin: 18, unit: "%" }
+  },
+  // =============================================================================
+  // VITAMINS
+  // =============================================================================
+  Lipoprotein_a: {
+    default: { max: 75, min: 0, optimalMax: 30, optimalMin: 0, unit: "nmol/L" },
+    direction: "lower-better"
+  },
+  Lymphocytes: {
+    default: { max: 40, min: 20, optimalMax: 35, optimalMin: 25, unit: "%" }
+  },
+  Lymphocytes_Abs: {
+    default: { max: 4, min: 1, optimalMax: 3, optimalMin: 1.5, unit: "K/uL" }
+  },
+  Magnesium: {
+    default: { max: 2.2, min: 1.7, optimalMax: 2.1, optimalMin: 1.9, unit: "mg/dL" }
+  },
+  Magnesium_RBC: {
+    default: { max: 6.8, min: 4, optimalMax: 6, optimalMin: 4.5, unit: "mg/dL" }
+  },
+  MCH: {
+    default: { max: 33, min: 27, optimalMax: 32, optimalMin: 28, unit: "pg" }
+  },
+  MCHC: {
+    default: { max: 36, min: 32, optimalMax: 35, optimalMin: 33, unit: "g/dL" }
+  },
+  MCV: {
+    default: { max: 100, min: 80, optimalMax: 98, optimalMin: 82, unit: "fL" }
+  },
+  Mercury: {
+    default: { max: 10, min: 0, optimalMax: 5, optimalMin: 0, unit: "mcg/L" }
+  },
+  Microalbumin: {
+    default: { max: 30, min: 0, optimalMax: 20, optimalMin: 0, unit: "mg/L" }
+  },
+  // =============================================================================
+  // HORMONES
+  // =============================================================================
+  MMA: {
+    default: { max: 378, min: 0, optimalMax: 270, optimalMin: 0, unit: "nmol/L" }
+  },
+  Monocytes: {
+    default: { max: 8, min: 2, optimalMax: 7, optimalMin: 3, unit: "%" }
+  },
+  Monocytes_Abs: {
+    default: { max: 0.8, min: 0.2, optimalMax: 0.7, optimalMin: 0.3, unit: "K/uL" }
+  },
+  MPV: {
+    default: { max: 11.5, min: 7.5, optimalMax: 10.5, optimalMin: 8, unit: "fL" }
+  },
+  Myeloperoxidase: {
+    default: { max: 420, min: 0, optimalMax: 300, optimalMin: 0, unit: "pmol/L" }
+  },
+  // WBC Differential (%)
+  Neutrophils: {
+    default: { max: 70, min: 40, optimalMax: 65, optimalMin: 50, unit: "%" }
+  },
+  // WBC Differential (Absolute)
+  Neutrophils_Abs: {
+    default: { max: 8, min: 1.5, optimalMax: 6, optimalMin: 2, unit: "K/uL" }
+  },
+  NonHDL_Cholesterol: {
+    default: { max: 130, min: 0, optimalMax: 100, optimalMin: 0, unit: "mg/dL" },
+    direction: "lower-better"
+  },
+  NRBC: {
+    default: { max: 0, min: 0, optimalMax: 0, optimalMin: 0, unit: "/100WBC" }
+  },
+  NTproBNP: {
+    default: { max: 125, min: 0, optimalMax: 75, optimalMin: 0, unit: "pg/mL" }
+  },
+  Oleic_Acid: {
+    default: { max: 25, min: 15, optimalMax: 22, optimalMin: 18, unit: "%" }
+  },
+  Omega3_Index: {
+    default: { max: 8, min: 4, optimalMax: 8, optimalMin: 5.5, unit: "%" }
+  },
+  Omega3_Total: {
+    default: { max: 12, min: 3, optimalMax: 10, optimalMin: 5.5, unit: "%" }
+  },
+  Omega6_Total: {
+    default: { max: 40, min: 20, optimalMax: 35, optimalMin: 25, unit: "%" }
+  },
+  Omega6_Omega3_Ratio: {
+    default: { max: 10, min: 1, optimalMax: 4, optimalMin: 1, unit: "" },
+    direction: "lower-better"
+  },
+  // =============================================================================
+  // TUMOR MARKERS
+  // =============================================================================
+  OmegaCheck: {
+    default: { max: 8, min: 4, optimalMax: 8, optimalMin: 5.5, unit: "%" }
+  },
+  Palmitic_Acid: {
+    default: { max: 30, min: 20, optimalMax: 27, optimalMin: 22, unit: "%" }
+  },
+  Phosphorus: {
+    default: { max: 4.5, min: 2.5, optimalMax: 4, optimalMin: 3, unit: "mg/dL" }
+  },
+  Platelets: {
+    default: { max: 400, min: 150, optimalMax: 350, optimalMin: 180, unit: "K/uL" }
+  },
+  Potassium: {
+    default: { max: 5, min: 3.5, optimalMax: 4.6, optimalMin: 3.8, unit: "mEq/L" }
+  },
+  // =============================================================================
+  // CARDIAC MARKERS
+  // =============================================================================
+  Prealbumin: {
+    default: { max: 38, min: 18, optimalMax: 35, optimalMin: 20, unit: "mg/dL" }
+  },
+  Progesterone: {
+    default: { max: 0.9, min: 0.1, optimalMax: 0.7, optimalMin: 0.2, unit: "ng/mL" }
+  },
+  Prolactin: {
+    default: { max: 18, min: 2, optimalMax: 15, optimalMin: 4, unit: "ng/mL" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 18, min: 2, optimalMax: 15, optimalMin: 4, unit: "ng/mL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 29, min: 2, optimalMax: 23, optimalMin: 4, unit: "ng/mL" },
+        sex: "F"
+      }
+    ]
+  },
+  PSA: {
+    default: { max: 4, min: 0, optimalMax: 2.5, optimalMin: 0, unit: "ng/mL" },
+    variants: [
+      {
+        ageMax: 49,
+        ageMin: 18,
+        range: { max: 2.5, min: 0, optimalMax: 1.5, optimalMin: 0, unit: "ng/mL" },
+        sex: "M"
+      },
+      {
+        ageMax: 59,
+        ageMin: 50,
+        range: { max: 3.5, min: 0, optimalMax: 2.5, optimalMin: 0, unit: "ng/mL" },
+        sex: "M"
+      },
+      {
+        ageMax: 69,
+        ageMin: 60,
+        range: { max: 4.5, min: 0, optimalMax: 3, optimalMin: 0, unit: "ng/mL" },
+        sex: "M"
+      },
+      {
+        ageMin: 70,
+        range: { max: 6.5, min: 0, optimalMax: 4, optimalMin: 0, unit: "ng/mL" },
+        sex: "M"
+      }
+    ]
+  },
+  RBC: {
+    default: { max: 5.5, min: 4, optimalMax: 5.2, optimalMin: 4.3, unit: "M/uL" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 5.9, min: 4.5, optimalMax: 5.5, optimalMin: 4.7, unit: "M/uL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 5.2, min: 4, optimalMax: 5, optimalMin: 4.2, unit: "M/uL" },
+        sex: "F"
+      }
+    ]
+  },
+  // =============================================================================
+  // URINALYSIS
+  // =============================================================================
+  RDW: {
+    default: { max: 14.5, min: 11.5, optimalMax: 14, optimalMin: 12, unit: "%" }
+  },
+  Reticulocytes: {
+    default: { max: 2.5, min: 0.5, optimalMax: 2, optimalMin: 0.8, unit: "%" }
+  },
+  SDMA: {
+    default: { max: 0.6, min: 0.3, optimalMax: 0.5, optimalMin: 0.3, unit: "umol/L" }
+  },
+  Selenium: {
+    default: { max: 150, min: 70, optimalMax: 125, optimalMin: 85, unit: "mcg/L" }
+  },
+  SHBG: {
+    default: { max: 54, min: 18, optimalMax: 50, optimalMin: 20, unit: "nmol/L" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 54, min: 18, optimalMax: 45, optimalMin: 20, unit: "nmol/L" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 122, min: 24, optimalMax: 90, optimalMin: 30, unit: "nmol/L" },
+        sex: "F"
+      }
+    ]
+  },
+  Sodium: {
+    default: { max: 145, min: 136, optimalMax: 143, optimalMin: 138, unit: "mEq/L" }
+  },
+  // =============================================================================
+  // KIDNEY FUNCTION
+  // =============================================================================
+  SpecificGravity_Urine: {
+    default: { max: 1.03, min: 1.005, optimalMax: 1.025, optimalMin: 1.01, unit: "SG" }
+  },
+  Stearic_Acid: {
+    default: { max: 14, min: 8, optimalMax: 12, optimalMin: 10, unit: "%" }
+  },
+  T3Free: {
+    default: { max: 4.2, min: 2.3, optimalMax: 3.8, optimalMin: 2.8, unit: "pg/mL" }
+  },
+  // =============================================================================
+  // OMEGA FATTY ACIDS
+  // =============================================================================
+  T3Reverse: {
+    default: { max: 27, min: 9, optimalMax: 22, optimalMin: 12, unit: "ng/dL" }
+  },
+  T4Free: {
+    default: { max: 1.8, min: 0.8, optimalMax: 1.5, optimalMin: 1, unit: "ng/dL" }
+  },
+  T4Total: {
+    default: { max: 12, min: 4.5, optimalMax: 10, optimalMin: 6, unit: "ug/dL" }
+  },
+  Testosterone: {
+    default: { max: 1e3, min: 300, optimalMax: 800, optimalMin: 500, unit: "ng/dL" },
+    variants: [
+      {
+        ageMax: 49,
+        ageMin: 18,
+        range: { max: 1e3, min: 300, optimalMax: 800, optimalMin: 500, unit: "ng/dL" },
+        sex: "M"
+      },
+      {
+        ageMin: 50,
+        range: { max: 800, min: 200, optimalMax: 650, optimalMin: 400, unit: "ng/dL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 70, min: 15, optimalMax: 50, optimalMin: 20, unit: "ng/dL" },
+        sex: "F"
+      }
+    ]
+  },
+  TestosteroneBioavailable: {
+    default: { max: 200, min: 50, optimalMax: 150, optimalMin: 80, unit: "ng/dL" }
+  },
+  // TestosteroneFree - using direct immunoassay ranges (Quest/LabCorp standard)
+  // Previous values (9.3-26.5 pg/mL) were based on equilibrium dialysis method
+  TestosteroneFree: {
+    default: { max: 155, min: 35, optimalMax: 120, optimalMin: 50, unit: "pg/mL" },
+    variants: [
+      {
+        ageMax: 49,
+        ageMin: 18,
+        range: { max: 155, min: 35, optimalMax: 120, optimalMin: 50, unit: "pg/mL" },
+        sex: "M"
+      },
+      {
+        ageMin: 50,
+        range: { max: 130, min: 30, optimalMax: 100, optimalMin: 40, unit: "pg/mL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 5, min: 0.2, optimalMax: 3, optimalMin: 0.5, unit: "pg/mL" },
+        sex: "F"
+      }
+    ]
+  },
+  TIBC: {
+    default: { max: 400, min: 250, optimalMax: 370, optimalMin: 280, unit: "mcg/dL" }
+  },
+  TotalProtein: {
+    default: { max: 8.3, min: 6, optimalMax: 7.8, optimalMin: 6.5, unit: "g/dL" }
+  },
+  Trans_Fat_Index: {
+    default: { max: 1, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "%" }
+  },
+  Transferrin: {
+    default: { max: 360, min: 200, optimalMax: 340, optimalMin: 220, unit: "mg/dL" }
+  },
+  TransferrinSaturation: {
+    default: { max: 50, min: 20, optimalMax: 45, optimalMin: 25, unit: "%" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 55, min: 20, optimalMax: 45, optimalMin: 25, unit: "%" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 50, min: 15, optimalMax: 40, optimalMin: 20, unit: "%" },
+        sex: "F"
+      }
+    ]
+  },
+  Triglycerides: {
+    default: { max: 150, min: 0, optimalMax: 100, optimalMin: 0, unit: "mg/dL" },
+    direction: "lower-better",
+    source: "sbc-lipids-2017"
+  },
+  TroponinI: {
+    default: { max: 0.04, min: 0, optimalMax: 0.02, optimalMin: 0, unit: "ng/mL" }
+  },
+  TroponinT: {
+    default: { max: 14, min: 0, optimalMax: 10, optimalMin: 0, unit: "ng/L" }
+  },
+  TSH: {
+    default: { max: 4, min: 0.4, optimalMax: 2.5, optimalMin: 1, unit: "\xB5IU/mL" },
+    source: "sbem-thyroid-2013",
+    variants: [
+      {
+        ageMin: 65,
+        range: { max: 6, min: 0.4, optimalMax: 4, optimalMin: 1, unit: "\xB5IU/mL" },
+        sex: "all"
+      }
+    ]
+  },
+  Urea: {
+    default: { max: 20, min: 7, optimalMax: 16, optimalMin: 10, unit: "mg/dL" }
+  },
+  UricAcid: {
+    default: { max: 7, min: 2.5, optimalMax: 5.5, optimalMin: 3, unit: "mg/dL" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 7, min: 3.4, optimalMax: 6, optimalMin: 4, unit: "mg/dL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 6, min: 2.4, optimalMax: 5, optimalMin: 3, unit: "mg/dL" },
+        sex: "F"
+      }
+    ]
+  },
+  Urobilinogen_Urine: {
+    default: { max: 1, min: 0.1, optimalMax: 1, optimalMin: 0.1, unit: "mg/dL" }
+  },
+  // =============================================================================
+  // ADVANCED CARDIOVASCULAR
+  // =============================================================================
+  pH_Urine: {
+    default: { max: 8, min: 4.5, optimalMax: 7, optimalMin: 5.5, unit: "pH" }
+  },
+  HyalineCasts_Urine: {
+    default: { max: 2, min: 0, optimalMax: 1, optimalMin: 0, unit: "/LPF" }
+  },
+  RBC_Urine: {
+    default: { max: 3, min: 0, optimalMax: 1, optimalMin: 0, unit: "/HPF" }
+  },
+  SquamousEpithelial_Urine: {
+    default: { max: 15, min: 0, optimalMax: 5, optimalMin: 0, unit: "/HPF" }
+  },
+  Leukocytes_Urine: {
+    default: { max: 5, min: 0, optimalMax: 2, optimalMin: 0, unit: "/HPF" }
+  },
+  Folate: {
+    default: { max: 20, min: 3.9, optimalMax: 17, optimalMin: 5, unit: "ng/mL" }
+  },
+  VitaminA: {
+    default: { max: 100, min: 20, optimalMax: 80, optimalMin: 30, unit: "mcg/dL" }
+  },
+  // =============================================================================
+  // MINERALS
+  // =============================================================================
+  VitaminB1: {
+    default: { max: 180, min: 70, optimalMax: 150, optimalMin: 80, unit: "nmol/L" }
+  },
+  VitaminB12: {
+    default: { max: 900, min: 200, optimalMax: 800, optimalMin: 400, unit: "pg/mL" },
+    source: "sbpc-ml-2021"
+  },
+  VitaminB6: {
+    default: { max: 50, min: 5, optimalMax: 40, optimalMin: 10, unit: "ng/mL" }
+  },
+  VitaminC: {
+    default: { max: 2, min: 0.4, optimalMax: 1.5, optimalMin: 0.6, unit: "mg/dL" }
+  },
+  // =============================================================================
+  // HEAVY METALS
+  // =============================================================================
+  VitaminD: {
+    default: { max: 100, min: 30, optimalMax: 70, optimalMin: 40, unit: "ng/mL" },
+    source: "sbem-thyroid-2013"
+  },
+  VitaminD_1_25: {
+    default: { max: 72, min: 18, optimalMax: 60, optimalMin: 25, unit: "pg/mL" }
+  },
+  VitaminE: {
+    default: { max: 17, min: 5.5, optimalMax: 14, optimalMin: 7, unit: "mg/L" }
+  },
+  VLDL: {
+    default: { max: 40, min: 5, optimalMax: 30, optimalMin: 10, unit: "mg/dL" }
+  },
+  // =============================================================================
+  // OTHER
+  // =============================================================================
+  WBC: {
+    default: { max: 11, min: 4, optimalMax: 8, optimalMin: 5, unit: "K/uL" }
+  },
+  Zinc: {
+    default: { max: 120, min: 60, optimalMax: 100, optimalMin: 70, unit: "mcg/dL" }
+  },
+  // =============================================================================
+  // BODY COMPOSITION (DXA)
+  // =============================================================================
+  AndroidFatPct: {
+    default: { max: 35, min: 10, optimalMax: 25, optimalMin: 15, unit: "%" },
+    direction: "lower-better",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 30, min: 10, optimalMax: 22, optimalMin: 12, unit: "%" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 42, min: 15, optimalMax: 32, optimalMin: 20, unit: "%" },
+        sex: "F"
+      }
+    ]
+  },
+  AndroidGynoidRatio: {
+    default: { max: 1.2, min: 0.5, optimalMax: 1, optimalMin: 0.6, unit: "" },
+    direction: "lower-better",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 1.2, min: 0.6, optimalMax: 1, optimalMin: 0.7, unit: "" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 1, min: 0.4, optimalMax: 0.8, optimalMin: 0.5, unit: "" },
+        sex: "F"
+      }
+    ]
+  },
+  BMC: {
+    default: { max: 3.5, min: 2, optimalMax: 3.2, optimalMin: 2.3, unit: "kg" },
+    direction: "higher-better",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 4, min: 2.5, optimalMax: 3.5, optimalMin: 2.8, unit: "kg" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 3, min: 1.8, optimalMax: 2.7, optimalMin: 2, unit: "kg" },
+        sex: "F"
+      }
+    ]
+  },
+  // BodyFatPct — Age-bracketed ranges from Gallagher et al. Am J Clin Nutr 2000;72:694-701
+  // (PMID: 10966886) and ACSM Guidelines for Exercise Testing, 11th Ed (2021)
+  BodyFatPct: {
+    default: { max: 30, min: 10, optimalMax: 25, optimalMin: 15, unit: "%" },
+    direction: "lower-better",
+    variants: [
+      // Men — age brackets
+      {
+        ageMax: 25,
+        ageMin: 18,
+        range: { max: 25, min: 5, optimalMax: 20, optimalMin: 10, unit: "%" },
+        sex: "M"
+      },
+      {
+        ageMax: 35,
+        ageMin: 26,
+        range: { max: 26, min: 5, optimalMax: 21, optimalMin: 11, unit: "%" },
+        sex: "M"
+      },
+      {
+        ageMax: 45,
+        ageMin: 36,
+        range: { max: 27, min: 5, optimalMax: 22, optimalMin: 12, unit: "%" },
+        sex: "M"
+      },
+      {
+        ageMax: 55,
+        ageMin: 46,
+        range: { max: 28, min: 5, optimalMax: 23, optimalMin: 13, unit: "%" },
+        sex: "M"
+      },
+      {
+        ageMin: 56,
+        range: { max: 29, min: 5, optimalMax: 24, optimalMin: 14, unit: "%" },
+        sex: "M"
+      },
+      // Women — age brackets
+      {
+        ageMax: 25,
+        ageMin: 18,
+        range: { max: 32, min: 13, optimalMax: 28, optimalMin: 18, unit: "%" },
+        sex: "F"
+      },
+      {
+        ageMax: 35,
+        ageMin: 26,
+        range: { max: 33, min: 13, optimalMax: 29, optimalMin: 18, unit: "%" },
+        sex: "F"
+      },
+      {
+        ageMax: 45,
+        ageMin: 36,
+        range: { max: 34, min: 13, optimalMax: 30, optimalMin: 19, unit: "%" },
+        sex: "F"
+      },
+      {
+        ageMax: 55,
+        ageMin: 46,
+        range: { max: 35, min: 13, optimalMax: 31, optimalMin: 20, unit: "%" },
+        sex: "F"
+      },
+      {
+        ageMin: 56,
+        range: { max: 36, min: 13, optimalMax: 32, optimalMin: 20, unit: "%" },
+        sex: "F"
+      }
+    ]
+  },
+  FatFreeMass: {
+    default: { max: 80, min: 40, optimalMax: 70, optimalMin: 45, unit: "kg" },
+    direction: "higher-better",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 90, min: 50, optimalMax: 80, optimalMin: 55, unit: "kg" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 60, min: 35, optimalMax: 52, optimalMin: 38, unit: "kg" },
+        sex: "F"
+      }
+    ]
+  },
+  FatMass: {
+    default: { max: 30, min: 5, optimalMax: 20, optimalMin: 8, unit: "kg" },
+    direction: "lower-better",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 25, min: 5, optimalMax: 18, optimalMin: 7, unit: "kg" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 30, min: 8, optimalMax: 22, optimalMin: 10, unit: "kg" },
+        sex: "F"
+      }
+    ]
+  },
+  GynoidFatPct: {
+    default: { max: 45, min: 15, optimalMax: 35, optimalMin: 20, unit: "%" },
+    direction: "lower-better",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 35, min: 12, optimalMax: 28, optimalMin: 15, unit: "%" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 50, min: 20, optimalMax: 40, optimalMin: 25, unit: "%" },
+        sex: "F"
+      }
+    ]
+  },
+  LeanMass: {
+    default: { max: 75, min: 35, optimalMax: 65, optimalMin: 40, unit: "kg" },
+    direction: "higher-better",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 85, min: 45, optimalMax: 75, optimalMin: 50, unit: "kg" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 55, min: 30, optimalMax: 48, optimalMin: 35, unit: "kg" },
+        sex: "F"
+      }
+    ]
+  },
+  TotalMass: {
+    default: { max: 100, min: 50, optimalMax: 85, optimalMin: 55, unit: "kg" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 100, min: 55, optimalMax: 90, optimalMin: 60, unit: "kg" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 85, min: 45, optimalMax: 75, optimalMin: 50, unit: "kg" },
+        sex: "F"
+      }
+    ]
+  },
+  VATMass: {
+    default: { max: 1.5, min: 0, optimalMax: 0.8, optimalMin: 0, unit: "kg" },
+    direction: "lower-better",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 1.5, min: 0, optimalMax: 1, optimalMin: 0, unit: "kg" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 1, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "kg" },
+        sex: "F"
+      }
+    ]
+  },
+  VATVolume: {
+    default: { max: 1500, min: 0, optimalMax: 800, optimalMin: 0, unit: "cm\xB3" },
+    direction: "lower-better",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 1500, min: 0, optimalMax: 1e3, optimalMin: 0, unit: "cm\xB3" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 1e3, min: 0, optimalMax: 500, optimalMin: 0, unit: "cm\xB3" },
+        sex: "F"
+      }
+    ]
+  },
+  // =============================================================================
+  // BONE DENSITOMETRY (DXA)
+  // =============================================================================
+  BMD_Total: {
+    default: { max: 1.4, min: 0.9, optimalMax: 1.3, optimalMin: 1, unit: "g/cm\xB2" },
+    direction: "higher-better"
+  },
+  TScore_Total: {
+    default: { max: 4, min: -1, optimalMax: 2, optimalMin: -0.5, unit: "" },
+    direction: "higher-better"
+  },
+  ZScore_Total: {
+    default: { max: 2, min: -2, optimalMax: 1, optimalMin: -1, unit: "" },
+    direction: "higher-better"
+  },
+  // =============================================================================
+  // MISSING LAB RANGES
+  // =============================================================================
+  Amylase: {
+    default: { max: 100, min: 28, optimalMax: 90, optimalMin: 35, unit: "U/L" }
+  },
+  Creatinine_Urine: {
+    default: { max: 300, min: 20, optimalMax: 250, optimalMin: 40, unit: "mg/dL" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 300, min: 40, optimalMax: 260, optimalMin: 60, unit: "mg/dL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 220, min: 20, optimalMax: 180, optimalMin: 40, unit: "mg/dL" },
+        sex: "F"
+      }
+    ]
+  },
+  IgA: {
+    default: { max: 400, min: 70, optimalMax: 350, optimalMin: 100, unit: "mg/dL" }
+  },
+  Lipase: {
+    default: { max: 60, min: 0, optimalMax: 50, optimalMin: 10, unit: "U/L" }
+  },
+  Microalbumin_Urine: {
+    default: { max: 30, min: 0, optimalMax: 20, optimalMin: 0, unit: "mg/L" }
+  },
+  PSA_Free: {
+    default: { max: 1.5, min: 0, optimalMax: 1, optimalMin: 0, unit: "ng/mL" }
+  },
+  PSA_FreeRatio: {
+    default: { max: 100, min: 25, optimalMax: 100, optimalMin: 30, unit: "%" }
+  },
+  // BMI - WHO classification: 18.5–24.9 normal, 25–29.9 overweight, ≥30 obese
+  BMI: {
+    default: { max: 30, min: 18.5, optimalMax: 24.9, optimalMin: 18.5, unit: "kg/m2" }
+  },
+  // eAG - Estimated Average Glucose, derived from HbA1c (ADAG study)
+  eAG: {
+    default: { max: 154, min: 70, optimalMax: 126, optimalMin: 70, unit: "mg/dL" }
+  },
+  // INR - International Normalized Ratio (non-anticoagulated patients)
+  INR: {
+    default: { max: 1.2, min: 0.8, optimalMax: 1.1, optimalMin: 0.9, unit: "ratio" }
+  },
+  // Prothrombin Time
+  ProthrombinTime: {
+    default: { max: 13.5, min: 11, optimalMax: 13, optimalMin: 11, unit: "seconds" }
+  },
+  // DHT - Dihydrotestosterone (adult male reference; female values are much lower)
+  DHT: {
+    default: { max: 85, min: 30, optimalMax: 85, optimalMin: 30, unit: "ng/dL" },
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 85, min: 30, optimalMax: 85, optimalMin: 30, unit: "ng/dL" },
+        sex: "M"
+      },
+      {
+        ageMin: 18,
+        range: { max: 22, min: 4, optimalMax: 22, optimalMin: 4, unit: "ng/dL" },
+        sex: "F"
+      }
+    ]
+  },
+  // Total IgE - higher values suggest atopy/allergic sensitization
+  IgE_Total: {
+    default: { max: 100, min: 0, optimalMax: 100, optimalMin: 0, unit: "IU/mL" },
+    direction: "lower-better"
+  },
+  // IgG - Immunoglobulin G
+  IgG: {
+    default: { max: 1600, min: 700, optimalMax: 1600, optimalMin: 700, unit: "mg/dL" }
+  },
+  // IgE E1 Cat Dander - Class 0 (≤0.35 kU/L) = negative
+  IgE_E1_CatDander: {
+    default: { max: 0.35, min: 0, optimalMax: 0.35, optimalMin: 0, unit: "kU/L" },
+    direction: "lower-better"
+  },
+  // IgE GX1 Grasses - Class 0 (≤0.35 kU/L) = negative
+  IgE_GX1_Grasses: {
+    default: { max: 0.35, min: 0, optimalMax: 0.35, optimalMin: 0, unit: "kU/L" },
+    direction: "lower-better"
+  }
+};
+var defaultReferenceRanges = Object.fromEntries(
+  Object.entries(biomarkerRangeDefinitions).map(([code, def]) => [code, def.default])
+);
+function getReferenceRange(testCode, context) {
+  const definition = biomarkerRangeDefinitions[testCode];
+  if (!definition) return void 0;
+  if (!context || !definition.variants || definition.variants.length === 0) {
+    return definition.default;
+  }
+  const { age, biologicalSex } = context;
+  for (const variant of definition.variants) {
+    if (variant.sex !== "all" && variant.sex !== biologicalSex) {
+      continue;
+    }
+    if (variant.ageMin !== void 0 && (age === void 0 || age < variant.ageMin)) {
+      continue;
+    }
+    if (variant.ageMax !== void 0 && (age === void 0 || age > variant.ageMax)) {
+      continue;
+    }
+    return variant.range;
+  }
+  return definition.default;
+}
+function getRangeDirection(testCode) {
+  return _nullishCoalesce(_optionalChain([biomarkerRangeDefinitions, 'access', _ => _[testCode], 'optionalAccess', _2 => _2.direction]), () => ( "range"));
+}
+function getFallbackReferenceRange(biomarkerCode) {
+  const definition = biomarkerRangeDefinitions[biomarkerCode];
+  if (!definition || definition.default.min === void 0 || definition.default.max === void 0) {
+    return void 0;
+  }
+  return {
+    max: definition.default.max,
+    min: definition.default.min,
+    unit: definition.default.unit
+  };
+}
+function applyFallbackReferenceRanges(biomarkers) {
+  let fallbackCount = 0;
+  for (const biomarker of biomarkers) {
+    if (biomarker.referenceMin != null && biomarker.referenceMax != null) {
+      continue;
+    }
+    const fallback = getFallbackReferenceRange(biomarker.code);
+    if (fallback) {
+      const canonicalUnit = _chunkGFXKYXHWcjs.getCanonicalUnit.call(void 0, biomarker.code);
+      const unitsMatch = !biomarker.unit || biomarker.unit.toLowerCase() === fallback.unit.toLowerCase() || canonicalUnit && biomarker.unit.toLowerCase() === canonicalUnit.toLowerCase() || // Handle common unit variations
+      biomarker.unit === "%" && fallback.unit === "%";
+      if (unitsMatch) {
+        if (biomarker.referenceMin == null) {
+          biomarker.referenceMin = fallback.min;
+        }
+        if (biomarker.referenceMax == null) {
+          biomarker.referenceMax = fallback.max;
+        }
+        fallbackCount++;
+      }
+    }
+  }
+  return fallbackCount;
+}
+
+
+
+
+
+
+
+
+exports.biomarkerRangeDefinitions = biomarkerRangeDefinitions; exports.defaultReferenceRanges = defaultReferenceRanges; exports.getReferenceRange = getReferenceRange; exports.getRangeDirection = getRangeDirection; exports.getFallbackReferenceRange = getFallbackReferenceRange; exports.applyFallbackReferenceRanges = applyFallbackReferenceRanges;
+//# sourceMappingURL=chunk-2X6MT5KE.cjs.map