@precisa-saude/fhir 0.1.0

package/dist/chunk-VPMT4MRS.js

@@ -0,0 +1,436 @@
+// src/units.ts
+var UNIT_TO_UCUM = {
+  // Dimensionless / special measurements
+  "[pH]": "[pH]",
+  "{ratio}": "{ratio}",
+  "{specific gravity}": "{specific gravity}",
+  "/\xB5L": "/uL",
+  // Percentage
+  "%": "%",
+  // Count units
+  "10\xB3/\xB5L": "10*3/uL",
+  "10\u2076/\xB5L": "10*6/uL",
+  // Volume
+  fL: "fL",
+  g: "g",
+  // Mass concentration
+  "g/dL": "g/dL",
+  L: "L",
+  // Molar concentration
+  "mEq/L": "meq/L",
+  mg: "mg",
+  "mg/dL": "mg/dL",
+  mL: "mL",
+  "mmol/L": "mmol/L",
+  "mUI/mL": "m[IU]/mL",
+  ng: "ng",
+  "ng/dL": "ng/dL",
+  "ng/mL": "ng/mL",
+  "nmol/L": "nmol/L",
+  // Mass
+  pg: "pg",
+  "pg/mL": "pg/mL",
+  pH: "[pH]",
+  // Enzyme activity
+  "U/L": "U/L",
+  // Special units
+  "U/mL": "U/mL",
+  "UI/L": "[IU]/L",
+  "UI/mL": "[IU]/mL",
+  \u00B5g: "ug",
+  "\xB5g/dL": "ug/dL",
+  "\xB5mol/L": "umol/L",
+  "\xB5UI/mL": "u[IU]/mL"
+};
+var BIOMARKER_DEFAULT_UNIT = {
+  // Proteins
+  Albumin: "g/dL",
+  AlkalinePhosphatase: "U/L",
+  // Liver
+  ALT: "U/L",
+  AST: "U/L",
+  Calcium: "mg/dL",
+  Chloride: "mEq/L",
+  // Lipids
+  Cholesterol: "mg/dL",
+  // Kidney
+  Creatinine: "mg/dL",
+  eAG: "mg/dL",
+  Ferritin: "ng/mL",
+  FolicAcid: "ng/mL",
+  GGT: "U/L",
+  // Glucose/Diabetes
+  Glucose: "mg/dL",
+  HbA1c: "%",
+  Hct: "%",
+  HDL: "mg/dL",
+  // Hematology
+  Hgb: "g/dL",
+  Insulin: "\xB5UI/mL",
+  // Iron studies
+  Iron: "\xB5g/dL",
+  LDL: "mg/dL",
+  Magnesium: "mg/dL",
+  NonHDL_Cholesterol: "mg/dL",
+  // Urinalysis - dimensionless
+  pH_Urine: "[pH]",
+  Potassium: "mEq/L",
+  RDW: "%",
+  // Electrolytes
+  Sodium: "mEq/L",
+  SpecificGravity_Urine: "{specific gravity}",
+  T3Free: "pg/mL",
+  T4Free: "ng/dL",
+  TIBC: "\xB5g/dL",
+  TotalProtein: "g/dL",
+  TransferrinSaturation: "%",
+  Triglycerides: "mg/dL",
+  // Thyroid
+  TSH: "\xB5UI/mL",
+  Urea: "mg/dL",
+  UricAcid: "mg/dL",
+  // Vitamins
+  VitaminB12: "pg/mL",
+  VitaminD: "ng/mL",
+  VLDL: "mg/dL"
+};
+function unitToUCUM(unit) {
+  return UNIT_TO_UCUM[unit] || unit;
+}
+function getDefaultUnit(biomarkerCode) {
+  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || "";
+}
+var CBC_DIFF_ALIASES = {
+  "/ul": "/uL",
+  "/\xB5l": "/uL",
+  "10*3/ul": "K/uL",
+  "cells/ul": "/uL",
+  "cells/\xB5l": "/uL",
+  "k/ul": "K/uL",
+  "x10e3/ul": "K/uL"
+};
+var CBC_DIFF = {
+  canonicalUcum: "10*3/uL",
+  canonicalUnit: "K/uL",
+  siUcum: "10*3/uL",
+  siUnit: "K/uL"
+};
+var DEXA_KG_ALIASES = {
+  kg: "kg",
+  lb: "[lb_av]",
+  lbs: "[lb_av]"
+};
+var DEXA_KG = {
+  canonicalUcum: "kg",
+  canonicalUnit: "kg",
+  siUcum: "kg",
+  siUnit: "kg"
+};
+var URINE_SEDIMENT_ALIASES = {
+  "/hpf": "/HPF",
+  "/ml": "/mL"
+};
+var URINE_SEDIMENT = {
+  canonicalUcum: "/[HPF]",
+  canonicalUnit: "/HPF",
+  siUcum: "/[HPF]",
+  siUnit: "/HPF"
+};
+var BIOMARKER_UNITS = {
+  Albumin: {
+    aliases: { "g/dl": "g/dL", "g/l": "g/L" },
+    canonicalUcum: "g/dL",
+    canonicalUnit: "g/dL",
+    siUcum: "g/L",
+    siUnit: "g/L"
+  },
+  AntiThyroglobulin: {
+    aliases: { "iu/ml": "IU/mL", "ui/ml": "IU/mL" },
+    canonicalUcum: "[iU]/mL",
+    canonicalUnit: "IU/mL",
+    siUcum: "[iU]/mL",
+    siUnit: "IU/mL"
+  },
+  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  Cholesterol: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 386.65,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  Creatinine: {
+    aliases: { "mg/dl": "mg/dL", "umol/l": "\xB5mol/L", "\xB5mol/l": "\xB5mol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 113.12,
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  CRP: {
+    aliases: { "mg/dl": "mg/dL", "mg/l": "mg/L" },
+    canonicalUcum: "mg/L",
+    canonicalUnit: "mg/L",
+    siUcum: "mg/L",
+    siUnit: "mg/L"
+  },
+  eGFR: {
+    aliases: {
+      "ml/min/1,73 m2": "mL/min/1.73m\xB2",
+      "ml/min/1.73m2": "mL/min/1.73m\xB2",
+      "ml/min/1.73m\xB2": "mL/min/1.73m\xB2"
+    },
+    canonicalUcum: "mL/min/{1.73_m2}",
+    canonicalUnit: "mL/min/1.73m\xB2",
+    siUcum: "mL/min/{1.73_m2}",
+    siUnit: "mL/min/1.73m\xB2"
+  },
+  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  Estradiol: {
+    // TODO: ng/dL ≠ pg/mL (1 ng/dL = 10 pg/mL) — display-only alias for now
+    aliases: { "ng/dl": "pg/mL", "pg/ml": "pg/mL" },
+    canonicalUcum: "pg/mL",
+    canonicalUnit: "pg/mL",
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  Ferritin: {
+    aliases: {
+      "mcg/l": "ng/mL",
+      "microg/l": "ng/mL",
+      "ng/ml": "ng/mL",
+      "\xB5g/l": "ng/mL"
+    },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    siUcum: "ug/L",
+    siUnit: "\xB5g/L"
+  },
+  FSH: {
+    aliases: {
+      "iu/l": "mIU/mL",
+      "miu/ml": "mIU/mL",
+      "ui/l": "mIU/mL"
+    },
+    canonicalUcum: "mIU/mL",
+    canonicalUnit: "mIU/mL",
+    siUcum: "[iU]/L",
+    siUnit: "IU/L"
+  },
+  Glucose: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 180.156,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  HDL: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 386.65,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  Hgb: {
+    aliases: { "g/dl": "g/dL", "g/l": "g/L" },
+    canonicalUcum: "g/dL",
+    canonicalUnit: "g/dL",
+    siUcum: "g/L",
+    siUnit: "g/L"
+  },
+  Insulin: {
+    aliases: {
+      "mu/l": "uIU/mL",
+      "uiu/ml": "uIU/mL",
+      "\xB5u/ml": "uIU/mL",
+      "\xB5ui/ml": "uIU/mL"
+    },
+    canonicalUcum: "u[iU]/mL",
+    canonicalUnit: "uIU/mL",
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  Iron: {
+    aliases: {
+      "mcg/dl": "mcg/dL",
+      "microg/dl": "mcg/dL",
+      "ug/dl": "mcg/dL",
+      "\xB5g/dl": "mcg/dL"
+    },
+    canonicalUcum: "ug/dL",
+    canonicalUnit: "mcg/dL",
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  LDL: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 386.65,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  LDL_Peak_Size: {
+    aliases: { \u00E5: "Ao", angstrom: "Ao", ao: "Ao", nm: "nm" },
+    canonicalUcum: "Ao",
+    canonicalUnit: "Angstrom",
+    siUcum: "nm",
+    siUnit: "nm"
+  },
+  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },
+  LH: {
+    aliases: {
+      "iu/l": "mIU/mL",
+      "miu/ml": "mIU/mL",
+      "ui/l": "mIU/mL"
+    },
+    canonicalUcum: "mIU/mL",
+    canonicalUnit: "mIU/mL",
+    siUcum: "[iU]/L",
+    siUnit: "IU/L"
+  },
+  Lipoprotein_a: {
+    aliases: { "mg/dl": "mg/dL", "nmol/l": "nmol/L" },
+    canonicalUcum: "nmol/L",
+    canonicalUnit: "nmol/L",
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
+  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  MCHC: {
+    aliases: { "g/dl": "g/dL", "g/l": "g/L" },
+    canonicalUcum: "g/dL",
+    canonicalUnit: "g/dL",
+    siUcum: "g/L",
+    siUnit: "g/L"
+  },
+  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },
+  Prolactin: {
+    aliases: {
+      "microg/l": "ng/mL",
+      "ng/ml": "ng/mL",
+      "\xB5g/l": "ng/mL"
+    },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    siUcum: "ug/L",
+    siUnit: "\xB5g/L"
+  },
+  RBC: {
+    aliases: {
+      "/ul": "/uL",
+      "/\xB5l": "/uL",
+      "10*6/ul": "M/uL",
+      "cells/ul": "/uL",
+      "m/ul": "M/uL",
+      "milh\xF5es/mm3": "M/uL",
+      "milh\xF5es/mm\xB3": "M/uL",
+      "x10e6/ul": "M/uL"
+    },
+    canonicalUcum: "10*6/uL",
+    canonicalUnit: "M/uL",
+    siUcum: "10*6/uL",
+    siUnit: "M/uL"
+  },
+  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },
+  TestosteroneFree: {
+    // TODO: pmol/L ≠ pg/mL (needs MW conversion) — display-only alias for now
+    aliases: { "pg/ml": "pg/mL", "pmol/l": "pg/mL" },
+    canonicalUcum: "pg/mL",
+    canonicalUnit: "pg/mL",
+    molecularWeight: 288.42,
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  TIBC: {
+    aliases: {
+      "mcg/dl": "mcg/dL",
+      "microg/dl": "mcg/dL",
+      "ug/dl": "mcg/dL",
+      "\xB5g/dl": "mcg/dL"
+    },
+    canonicalUcum: "ug/dL",
+    canonicalUnit: "mcg/dL",
+    siUcum: "umol/L",
+    siUnit: "\xB5mol/L"
+  },
+  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  Triglycerides: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 885.4,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  TSH: {
+    aliases: {
+      "miu/l": "uIU/mL",
+      "mui/l": "uIU/mL",
+      "uiu/ml": "uIU/mL",
+      "\xB5ui/ml": "uIU/mL"
+    },
+    canonicalUcum: "u[iU]/mL",
+    canonicalUnit: "uIU/mL",
+    siUcum: "mIU/L",
+    siUnit: "mIU/L"
+  },
+  Urea: {
+    aliases: { "mg/dl": "mg/dL", "mmol/l": "mmol/L" },
+    canonicalUcum: "mg/dL",
+    canonicalUnit: "mg/dL",
+    molecularWeight: 60.06,
+    siUcum: "mmol/L",
+    siUnit: "mmol/L"
+  },
+  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },
+  VATVolume: {
+    aliases: { cm3: "cm3", "cm\xB3": "cm3", in3: "[in_i]3", "in\xB3": "[in_i]3" },
+    canonicalUcum: "cm3",
+    canonicalUnit: "cm\xB3",
+    siUcum: "cm3",
+    siUnit: "cm\xB3"
+  },
+  VitaminB12: {
+    aliases: { "ng/l": "pg/mL", "pg/ml": "pg/mL" },
+    canonicalUcum: "pg/mL",
+    canonicalUnit: "pg/mL",
+    siUcum: "pmol/L",
+    siUnit: "pmol/L"
+  },
+  VitaminD: {
+    aliases: { "ng/ml": "ng/mL", "nmol/l": "nmol/L" },
+    canonicalUcum: "ng/mL",
+    canonicalUnit: "ng/mL",
+    molecularWeight: 384.64,
+    siUcum: "nmol/L",
+    siUnit: "nmol/L"
+  },
+  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF }
+};
+function getCanonicalUnit(code) {
+  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;
+}
+function getSIUnit(code) {
+  return BIOMARKER_UNITS[code]?.siUnit ?? null;
+}
+
+export {
+  UNIT_TO_UCUM,
+  BIOMARKER_DEFAULT_UNIT,
+  unitToUCUM,
+  getDefaultUnit,
+  BIOMARKER_UNITS,
+  getCanonicalUnit,
+  getSIUnit
+};
+//# sourceMappingURL=chunk-VPMT4MRS.js.map

package/dist/chunk-VPMT4MRS.js.map

@@ -0,0 +1 @@
+{"version":3,"sources":["../src/units.ts"],"sourcesContent":["/**\n * Unit Mappings and Biomarker Unit Definitions\n *\n * Maps units to UCUM format, provides default units for biomarkers,\n * and defines canonical/SI unit configurations with aliases.\n */\n\n// ─── UCUM Mappings ───────────────────────────────────────────────────────────\n\n/**\n * Map units to UCUM (Unified Code for Units of Measure)\n * See: https://ucum.org/\n */\nexport const UNIT_TO_UCUM: Record<string, string> = {\n  // Dimensionless / special measurements\n  '[pH]': '[pH]',\n  '{ratio}': '{ratio}',\n  '{specific gravity}': '{specific gravity}',\n\n  '/µL': '/uL',\n  // Percentage\n  '%': '%',\n  // Count units\n  '10³/µL': '10*3/uL',\n  '10⁶/µL': '10*6/uL',\n  // Volume\n  fL: 'fL',\n  g: 'g',\n\n  // Mass concentration\n  'g/dL': 'g/dL',\n  L: 'L',\n  // Molar concentration\n  'mEq/L': 'meq/L',\n\n  mg: 'mg',\n  'mg/dL': 'mg/dL',\n  mL: 'mL',\n  'mmol/L': 'mmol/L',\n  'mUI/mL': 'm[IU]/mL',\n\n  ng: 'ng',\n\n  'ng/dL': 'ng/dL',\n  'ng/mL': 'ng/mL',\n  'nmol/L': 'nmol/L',\n  // Mass\n  pg: 'pg',\n\n  'pg/mL': 'pg/mL',\n  pH: '[pH]',\n  // Enzyme activity\n  'U/L': 'U/L',\n  // Special units\n  'U/mL': 'U/mL',\n  'UI/L': '[IU]/L',\n\n  'UI/mL': '[IU]/mL',\n\n  µg: 'ug',\n  'µg/dL': 'ug/dL',\n  'µmol/L': 'umol/L',\n  'µUI/mL': 'u[IU]/mL',\n};\n\n/**\n * Default units for biomarkers when source data doesn't provide one\n * These are the most common units used in Brazilian labs\n */\nexport const BIOMARKER_DEFAULT_UNIT: Record<string, string> = {\n  // Proteins\n  Albumin: 'g/dL',\n  AlkalinePhosphatase: 'U/L',\n  // Liver\n  ALT: 'U/L',\n  AST: 'U/L',\n\n  Calcium: 'mg/dL',\n  Chloride: 'mEq/L',\n  // Lipids\n  Cholesterol: 'mg/dL',\n  // Kidney\n  Creatinine: 'mg/dL',\n  eAG: 'mg/dL',\n  Ferritin: 'ng/mL',\n\n  FolicAcid: 'ng/mL',\n  GGT: 'U/L',\n  // Glucose/Diabetes\n  Glucose: 'mg/dL',\n\n  HbA1c: '%',\n  Hct: '%',\n\n  HDL: 'mg/dL',\n  // Hematology\n  Hgb: 'g/dL',\n  Insulin: 'µUI/mL',\n\n  // Iron studies\n  Iron: 'µg/dL',\n  LDL: 'mg/dL',\n  Magnesium: 'mg/dL',\n  NonHDL_Cholesterol: 'mg/dL',\n\n  // Urinalysis - dimensionless\n  pH_Urine: '[pH]',\n  Potassium: 'mEq/L',\n  RDW: '%',\n  // Electrolytes\n  Sodium: 'mEq/L',\n  SpecificGravity_Urine: '{specific gravity}',\n\n  T3Free: 'pg/mL',\n  T4Free: 'ng/dL',\n  TIBC: 'µg/dL',\n  TotalProtein: 'g/dL',\n\n  TransferrinSaturation: '%',\n  Triglycerides: 'mg/dL',\n  // Thyroid\n  TSH: 'µUI/mL',\n\n  Urea: 'mg/dL',\n  UricAcid: 'mg/dL',\n\n  // Vitamins\n  VitaminB12: 'pg/mL',\n  VitaminD: 'ng/mL',\n  VLDL: 'mg/dL',\n};\n\n/**\n * Convert unit to UCUM format\n */\nexport function unitToUCUM(unit: string): string {\n  return UNIT_TO_UCUM[unit] || unit;\n}\n\n/**\n * Get default unit for a biomarker code\n * @param biomarkerCode - The biomarker code (e.g., \"Glucose\", \"HbA1c\")\n * @returns The default unit or empty string if not found\n */\nexport function getDefaultUnit(biomarkerCode: string): string {\n  return BIOMARKER_DEFAULT_UNIT[biomarkerCode] || '';\n}\n\n// ─── Biomarker Unit Configurations ───────────────────────────────────────────\n\n/** Biomarker unit definitions — canonical units match reference-ranges.ts (BR conventional). */\n\nexport interface BiomarkerUnitConfig {\n  aliases: Record<string, string>;\n  canonicalUcum: string;\n  canonicalUnit: string;\n  molecularWeight?: number;\n  siUcum: string;\n  siUnit: string;\n}\n\nconst CBC_DIFF_ALIASES: Record<string, string> = {\n  '/ul': '/uL',\n  '/µl': '/uL',\n  '10*3/ul': 'K/uL',\n  'cells/ul': '/uL',\n  'cells/µl': '/uL',\n  'k/ul': 'K/uL',\n  'x10e3/ul': 'K/uL',\n};\nconst CBC_DIFF: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '10*3/uL',\n  canonicalUnit: 'K/uL',\n  siUcum: '10*3/uL',\n  siUnit: 'K/uL',\n};\nconst DEXA_KG_ALIASES: Record<string, string> = {\n  kg: 'kg',\n  lb: '[lb_av]',\n  lbs: '[lb_av]',\n};\nconst DEXA_KG: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: 'kg',\n  canonicalUnit: 'kg',\n  siUcum: 'kg',\n  siUnit: 'kg',\n};\n\n/**\n * Urine sediment units — Brazilian automated analyzers (Sysmex UF-series)\n * report in /mL while manual microscopy uses /HPF. Canonical unit is /HPF.\n */\nconst URINE_SEDIMENT_ALIASES: Record<string, string> = {\n  '/hpf': '/HPF',\n  '/ml': '/mL',\n};\nconst URINE_SEDIMENT: Omit<BiomarkerUnitConfig, 'aliases'> = {\n  canonicalUcum: '/[HPF]',\n  canonicalUnit: '/HPF',\n  siUcum: '/[HPF]',\n  siUnit: '/HPF',\n};\n\nexport const BIOMARKER_UNITS: Record<string, BiomarkerUnitConfig> = {\n  Albumin: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  AntiThyroglobulin: {\n    aliases: { 'iu/ml': 'IU/mL', 'ui/ml': 'IU/mL' },\n    canonicalUcum: '[iU]/mL',\n    canonicalUnit: 'IU/mL',\n    siUcum: '[iU]/mL',\n    siUnit: 'IU/mL',\n  },\n  Basophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  BMC: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Cholesterol: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  Creatinine: {\n    aliases: { 'mg/dl': 'mg/dL', 'umol/l': 'µmol/L', 'µmol/l': 'µmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 113.12,\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  CRP: {\n    aliases: { 'mg/dl': 'mg/dL', 'mg/l': 'mg/L' },\n    canonicalUcum: 'mg/L',\n    canonicalUnit: 'mg/L',\n    siUcum: 'mg/L',\n    siUnit: 'mg/L',\n  },\n  eGFR: {\n    aliases: {\n      'ml/min/1,73 m2': 'mL/min/1.73m²',\n      'ml/min/1.73m2': 'mL/min/1.73m²',\n      'ml/min/1.73m²': 'mL/min/1.73m²',\n    },\n    canonicalUcum: 'mL/min/{1.73_m2}',\n    canonicalUnit: 'mL/min/1.73m²',\n    siUcum: 'mL/min/{1.73_m2}',\n    siUnit: 'mL/min/1.73m²',\n  },\n  Eosinophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Estradiol: {\n    // TODO: ng/dL ≠ pg/mL (1 ng/dL = 10 pg/mL) — display-only alias for now\n    aliases: { 'ng/dl': 'pg/mL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  FatFreeMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  FatMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Ferritin: {\n    aliases: {\n      'mcg/l': 'ng/mL',\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  FSH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Glucose: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 180.156,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  HDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  Hgb: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Insulin: {\n    aliases: {\n      'mu/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  Iron: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  LDL: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 386.65,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  LDL_Peak_Size: {\n    aliases: { å: 'Ao', angstrom: 'Ao', ao: 'Ao', nm: 'nm' },\n    canonicalUcum: 'Ao',\n    canonicalUnit: 'Angstrom',\n    siUcum: 'nm',\n    siUnit: 'nm',\n  },\n  LeanMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Leukocytes_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  LH: {\n    aliases: {\n      'iu/l': 'mIU/mL',\n      'miu/ml': 'mIU/mL',\n      'ui/l': 'mIU/mL',\n    },\n    canonicalUcum: 'mIU/mL',\n    canonicalUnit: 'mIU/mL',\n    siUcum: '[iU]/L',\n    siUnit: 'IU/L',\n  },\n  Lipoprotein_a: {\n    aliases: { 'mg/dl': 'mg/dL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'nmol/L',\n    canonicalUnit: 'nmol/L',\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  Lymphocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  MCHC: {\n    aliases: { 'g/dl': 'g/dL', 'g/l': 'g/L' },\n    canonicalUcum: 'g/dL',\n    canonicalUnit: 'g/dL',\n    siUcum: 'g/L',\n    siUnit: 'g/L',\n  },\n  Monocytes_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Neutrophils_Abs: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Platelets: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n  Prolactin: {\n    aliases: {\n      'microg/l': 'ng/mL',\n      'ng/ml': 'ng/mL',\n      'µg/l': 'ng/mL',\n    },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    siUcum: 'ug/L',\n    siUnit: 'µg/L',\n  },\n  RBC: {\n    aliases: {\n      '/ul': '/uL',\n      '/µl': '/uL',\n      '10*6/ul': 'M/uL',\n      'cells/ul': '/uL',\n      'm/ul': 'M/uL',\n      'milhões/mm3': 'M/uL',\n      'milhões/mm³': 'M/uL',\n      'x10e6/ul': 'M/uL',\n    },\n    canonicalUcum: '10*6/uL',\n    canonicalUnit: 'M/uL',\n    siUcum: '10*6/uL',\n    siUnit: 'M/uL',\n  },\n  RBC_Urine: { aliases: URINE_SEDIMENT_ALIASES, ...URINE_SEDIMENT },\n  TestosteroneFree: {\n    // TODO: pmol/L ≠ pg/mL (needs MW conversion) — display-only alias for now\n    aliases: { 'pg/ml': 'pg/mL', 'pmol/l': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    molecularWeight: 288.42,\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  TIBC: {\n    aliases: {\n      'mcg/dl': 'mcg/dL',\n      'microg/dl': 'mcg/dL',\n      'ug/dl': 'mcg/dL',\n      'µg/dl': 'mcg/dL',\n    },\n    canonicalUcum: 'ug/dL',\n    canonicalUnit: 'mcg/dL',\n    siUcum: 'umol/L',\n    siUnit: 'µmol/L',\n  },\n  TotalMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  Triglycerides: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 885.4,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  TSH: {\n    aliases: {\n      'miu/l': 'uIU/mL',\n      'mui/l': 'uIU/mL',\n      'uiu/ml': 'uIU/mL',\n      'µui/ml': 'uIU/mL',\n    },\n    canonicalUcum: 'u[iU]/mL',\n    canonicalUnit: 'uIU/mL',\n    siUcum: 'mIU/L',\n    siUnit: 'mIU/L',\n  },\n  Urea: {\n    aliases: { 'mg/dl': 'mg/dL', 'mmol/l': 'mmol/L' },\n    canonicalUcum: 'mg/dL',\n    canonicalUnit: 'mg/dL',\n    molecularWeight: 60.06,\n    siUcum: 'mmol/L',\n    siUnit: 'mmol/L',\n  },\n  VATMass: { aliases: DEXA_KG_ALIASES, ...DEXA_KG },\n  VATVolume: {\n    aliases: { cm3: 'cm3', 'cm³': 'cm3', in3: '[in_i]3', 'in³': '[in_i]3' },\n    canonicalUcum: 'cm3',\n    canonicalUnit: 'cm³',\n    siUcum: 'cm3',\n    siUnit: 'cm³',\n  },\n  VitaminB12: {\n    aliases: { 'ng/l': 'pg/mL', 'pg/ml': 'pg/mL' },\n    canonicalUcum: 'pg/mL',\n    canonicalUnit: 'pg/mL',\n    siUcum: 'pmol/L',\n    siUnit: 'pmol/L',\n  },\n  VitaminD: {\n    aliases: { 'ng/ml': 'ng/mL', 'nmol/l': 'nmol/L' },\n    canonicalUcum: 'ng/mL',\n    canonicalUnit: 'ng/mL',\n    molecularWeight: 384.64,\n    siUcum: 'nmol/L',\n    siUnit: 'nmol/L',\n  },\n  WBC: { aliases: CBC_DIFF_ALIASES, ...CBC_DIFF },\n};\n\n/**\n * Get the canonical unit for a biomarker code.\n */\nexport function getCanonicalUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.canonicalUnit ?? null;\n}\n\n/**\n * Get the SI unit for a biomarker code.\n */\nexport function getSIUnit(code: string): string | null {\n  return BIOMARKER_UNITS[code]?.siUnit ?? 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