@jbrowse/bandage-core 10.2.7 → 10.3.0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/dist/alleleProjection/projectAlleles.js +8 -4
- package/dist/anchoredNodes.js +2 -1
- package/dist/bubbleSpreads.js +2 -2
- package/dist/bubbles/bubbleHalos.js +10 -11
- package/dist/bubbles/bubblesFromGraph.js +8 -3
- package/dist/bubbles/classifyBubble.js +9 -6
- package/dist/bubbles/popBubble.js +7 -5
- package/dist/bubbles/superbubbles.js +18 -14
- package/dist/chunks/{chunk-RAKOB6IV.js → chunk-234NFZS4.js} +8 -6
- package/dist/chunks/{chunk-A4PFFC4Q.js → chunk-2XEQR54X.js} +60 -102
- package/dist/chunks/{chunk-6JEWNXCQ.js → chunk-34BOZKIE.js} +0 -2
- package/dist/chunks/{chunk-RVS2QCOX.js → chunk-3GLG3ZLE.js} +2 -11
- package/dist/chunks/{chunk-PUG7LXDF.js → chunk-3PZSBNLI.js} +4 -1
- package/dist/chunks/{chunk-KBEP7VYK.js → chunk-3VCKBSML.js} +4 -4
- package/dist/chunks/{chunk-BPLIXMH7.js → chunk-4XWZNPQ2.js} +14 -0
- package/dist/chunks/{chunk-LKW2TP4N.js → chunk-5YILQTHE.js} +18 -16
- package/dist/chunks/{chunk-B6IW3IRE.js → chunk-65ILXEIN.js} +14 -15
- package/dist/chunks/{chunk-4DRQTBBE.js → chunk-6EOB6ANX.js} +1 -1
- package/dist/chunks/{chunk-QBHPHLAQ.js → chunk-7JGLJK44.js} +41 -36
- package/dist/chunks/{chunk-T2PCSAFY.js → chunk-7XR26JST.js} +2 -2
- package/dist/chunks/{chunk-URZ3CH2R.js → chunk-A4JDEUAI.js} +1 -1
- package/dist/chunks/{chunk-JLSJMCDJ.js → chunk-A54O52XZ.js} +3 -3
- package/dist/chunks/chunk-A55OZVYX.js +327 -0
- package/dist/chunks/{chunk-CWFNEKST.js → chunk-A7H753BA.js} +3 -3
- package/dist/chunks/{chunk-VV6KGJ7M.js → chunk-AMX4OQAW.js} +18 -27
- package/dist/chunks/{chunk-RPRHR56C.js → chunk-BS6HPYCZ.js} +3 -3
- package/dist/chunks/chunk-BSOZW3FC.js +30 -0
- package/dist/chunks/{chunk-CU6P5RUG.js → chunk-BVYR7IFN.js} +22 -16
- package/dist/chunks/{chunk-XXT2JCAC.js → chunk-BX4AUMZE.js} +11 -13
- package/dist/chunks/{chunk-N73TI3VG.js → chunk-BZFOFC4D.js} +6 -9
- package/dist/chunks/{chunk-4ETPXDO6.js → chunk-CGFPFBT2.js} +1 -1
- package/dist/chunks/{chunk-24WITXQY.js → chunk-CGMSKIEO.js} +9 -25
- package/dist/chunks/{chunk-IGVV37VI.js → chunk-CKUVEHSS.js} +3 -3
- package/dist/chunks/{chunk-JBCZIBFC.js → chunk-CRCD3ODN.js} +0 -1
- package/dist/chunks/{chunk-OIV2GBAJ.js → chunk-DBLV7PGG.js} +27 -17
- package/dist/chunks/{chunk-JA2HJIYS.js → chunk-E4ZM4OOJ.js} +3 -5
- package/dist/chunks/{chunk-ABUIN5AK.js → chunk-EHXBZ5JZ.js} +29 -24
- package/dist/chunks/{chunk-QLWI2PZ3.js → chunk-EJRJAAN7.js} +24 -21
- package/dist/chunks/{chunk-Q7LYHGGQ.js → chunk-GIHTHYXY.js} +5 -4
- package/dist/chunks/{chunk-L3O7AWLI.js → chunk-GJLZ2MKE.js} +2 -2
- package/dist/chunks/{chunk-LOEA5IHZ.js → chunk-GJU6BJJA.js} +8 -8
- package/dist/chunks/{chunk-XL472HHD.js → chunk-GQZVR5DW.js} +12 -7
- package/dist/chunks/{chunk-UVBGRJQX.js → chunk-HKYXWZQS.js} +1 -1
- package/dist/chunks/chunk-HMXCN6PG.js +17 -0
- package/dist/chunks/{chunk-WSIFAZU7.js → chunk-HNWJ4B7S.js} +12 -13
- package/dist/chunks/chunk-HOAIOEI7.js +18 -0
- package/dist/chunks/{chunk-XMW266WS.js → chunk-HSVFCA2J.js} +18 -20
- package/dist/chunks/{chunk-3XSM4OZU.js → chunk-IYALCKNB.js} +5 -5
- package/dist/chunks/{chunk-QXUEF3AJ.js → chunk-KWHWNOTY.js} +22 -17
- package/dist/chunks/{chunk-M6LK4GII.js → chunk-LGJBB5BP.js} +8 -9
- package/dist/chunks/{chunk-VQWHMWLF.js → chunk-M5NPD55W.js} +18 -14
- package/dist/chunks/{chunk-TKIJ5535.js → chunk-MD5VPXXT.js} +6 -6
- package/dist/chunks/{chunk-HK5Y2YWV.js → chunk-MYDHU2UV.js} +6 -11
- package/dist/chunks/{chunk-TZFWUT2C.js → chunk-MYLAJDKB.js} +2 -2
- package/dist/chunks/{chunk-4HWM3FNK.js → chunk-OMUPUB4J.js} +39 -56
- package/dist/chunks/{chunk-PTABFYQ7.js → chunk-PFRQBCGC.js} +49 -60
- package/dist/chunks/{chunk-T6V4KI2L.js → chunk-PPDE4IVT.js} +1 -1
- package/dist/chunks/{chunk-KC7T5RWG.js → chunk-PSCSZSVK.js} +9 -16
- package/dist/chunks/{chunk-CG35S2S2.js → chunk-PTQPTDZH.js} +1 -1
- package/dist/chunks/{chunk-L2HDM2R3.js → chunk-QQCOVMMT.js} +7 -7
- package/dist/chunks/{chunk-CQHUZHET.js → chunk-RFG42VIO.js} +46 -30
- package/dist/chunks/{chunk-FYQWPEEY.js → chunk-RJWPJCIB.js} +5 -11
- package/dist/chunks/{chunk-AR4BUBMU.js → chunk-RWKP7UO4.js} +34 -35
- package/dist/chunks/{chunk-WBSWROE6.js → chunk-SHKGYGM4.js} +14 -18
- package/dist/chunks/{chunk-2CMYNW3E.js → chunk-SI3BB4DO.js} +1 -1
- package/dist/chunks/{chunk-DY3JCAMX.js → chunk-SOMZGDVS.js} +7 -16
- package/dist/chunks/{chunk-EFQLEGWM.js → chunk-SZHQK6GL.js} +7 -8
- package/dist/chunks/{chunk-5GMFEPWR.js → chunk-TCOLHD7N.js} +16 -28
- package/dist/chunks/{chunk-XV4P5KEQ.js → chunk-TGUFT6KK.js} +6 -3
- package/dist/chunks/{chunk-CM6LO6OC.js → chunk-UAFATXYA.js} +10 -14
- package/dist/chunks/{chunk-7SRWJLSC.js → chunk-UBQSRCWR.js} +11 -8
- package/dist/chunks/{chunk-RUCH6ZFL.js → chunk-V4YML3GR.js} +2 -1
- package/dist/chunks/{chunk-VQC7KELB.js → chunk-V7J6U4XC.js} +11 -3
- package/dist/chunks/{chunk-ES2N6V56.js → chunk-VX656OAZ.js} +6 -11
- package/dist/chunks/chunk-WA5WNP6V.js +37 -0
- package/dist/chunks/{chunk-EQ2NIFRH.js → chunk-WJ4TIAVA.js} +1 -1
- package/dist/chunks/{chunk-A7CFWFQS.js → chunk-WONB6LMC.js} +1 -1
- package/dist/chunks/{chunk-23YFB5BB.js → chunk-XUT4HXVE.js} +29 -13
- package/dist/chunks/{chunk-G45YY72K.js → chunk-Z6XZWPXK.js} +17 -25
- package/dist/chunks/{chunk-XI3ZUTWF.js → chunk-ZNJ4JAPT.js} +14 -20
- package/dist/chunks/{chunk-AUFAPUO4.js → chunk-ZPBEUOBM.js} +3 -1
- package/dist/chunks/{chunk-RAEABQNW.js → chunk-ZPZ7GNBT.js} +1 -0
- package/dist/cli/figure.js +59 -56
- package/dist/cli/fold.js +19 -17
- package/dist/deletionEdges.js +5 -7
- package/dist/facetGrid.js +2 -1
- package/dist/figure.js +45 -42
- package/dist/figureData.js +48 -44
- package/dist/figureScene.js +34 -29
- package/dist/figureSettings.js +19 -17
- package/dist/foldVariants.js +5 -3
- package/dist/gbzCut.js +12 -7
- package/dist/gbzJoin.js +2 -1
- package/dist/gbzWindow.js +11 -6
- package/dist/genes/genePins.js +6 -4
- package/dist/gfa/gfaConverter.js +7 -5
- package/dist/gfa/gfaTables.js +2 -1
- package/dist/gfa/graphTables.js +3 -3
- package/dist/graphLabels.js +8 -5
- package/dist/index.js +88 -85
- package/dist/labelLayout.js +12 -9
- package/dist/layout/anchoredLayout.js +8 -5
- package/dist/layout/drawnScale.js +1 -5
- package/dist/layout/forceCache.js +19 -17
- package/dist/layout/mergeRuns.js +5 -3
- package/dist/layout/orderedLayout.js +5 -2
- package/dist/layout/orientToReference.js +3 -2
- package/dist/layout/placeOffReference.js +7 -4
- package/dist/layout/referenceSeeds.js +6 -4
- package/dist/layout/sampleRowLayout.js +8 -5
- package/dist/layout/trimToWindow.js +6 -4
- package/dist/layout/tubeMapLayout.js +17 -19
- package/dist/layout/walkRowDraw.js +18 -17
- package/dist/layout/walkRowLayout.js +10 -6
- package/dist/layout/walkRows.js +9 -5
- package/dist/layout/walkStrip.js +21 -18
- package/dist/layoutModes.js +23 -20
- package/dist/nodeWidths.js +1 -3
- package/dist/pansn.js +5 -1
- package/dist/pathAnchoring.js +6 -4
- package/dist/pathColors.js +12 -9
- package/dist/pathVisits.js +3 -1
- package/dist/pipeline.js +18 -16
- package/dist/reference.js +5 -3
- package/dist/referenceRampCss.js +9 -17
- package/dist/referenceSpan.js +4 -2
- package/dist/referenceStrip.js +18 -14
- package/dist/renderer/Canvas2DRenderer.js +1 -1
- package/dist/renderer/GeometryBuilder.js +19 -14
- package/dist/renderer/svgCanvas.js +1 -1
- package/dist/tubeMap/axis.js +11 -6
- package/dist/tubeMap/bundle.js +16 -12
- package/dist/tubeMap/coarsen.js +20 -345
- package/dist/tubeMap/deviations.js +53 -23
- package/dist/tubeMap/draw.js +11 -8
- package/dist/tubeMap/frame.js +3 -2
- package/dist/tubeMap/genes.js +10 -7
- package/dist/tubeMap/mismatches.js +1 -1
- package/dist/tubeMap/nodeColors.js +18 -14
- package/dist/tubeMap/reads.js +1 -1
- package/dist/tubeMap/warp.js +2 -1
- package/dist/types/alleleProjection/projectAlleles.d.ts +1 -4
- package/dist/types/bubbles/bubbleHalos.d.ts +0 -2
- package/dist/types/bubbles/bubblesFromGraph.d.ts +6 -4
- package/dist/types/bubbles/classifyBubble.d.ts +2 -1
- package/dist/types/deletionEdges.d.ts +0 -8
- package/dist/types/figureScene.d.ts +17 -7
- package/dist/types/figureSettings.d.ts +2 -0
- package/dist/types/gbzCut.d.ts +4 -0
- package/dist/types/gbzWindow.d.ts +1 -0
- package/dist/types/gfa-core/gfaParser.d.ts +1 -1
- package/dist/types/graphLabels.d.ts +2 -1
- package/dist/types/layout/drawnScale.d.ts +0 -2
- package/dist/types/layout/referenceSeeds.d.ts +2 -1
- package/dist/types/layout/tubeMapLayout.d.ts +0 -7
- package/dist/types/layout/walkRowDraw.d.ts +0 -1
- package/dist/types/layout/walkRowLayout.d.ts +1 -0
- package/dist/types/layout/walkRows.d.ts +1 -0
- package/dist/types/nodeWidths.d.ts +0 -1
- package/dist/types/pansn.d.ts +9 -0
- package/dist/types/pathVisits.d.ts +6 -0
- package/dist/types/referenceRampCss.d.ts +4 -0
- package/dist/types/renderer/Canvas2DRenderer.d.ts +1 -0
- package/dist/types/renderer/GeometryBuilder.d.ts +3 -2
- package/dist/types/tubeMap/axis.d.ts +3 -1
- package/dist/types/tubeMap/coarsen.d.ts +3 -1
- package/dist/types/tubeMap/deviations.d.ts +2 -1
- package/dist/types/tubeMap/mismatches.d.ts +0 -1
- package/dist/types/tubeMap/warp.d.ts +2 -1
- package/dist/types/util/SpatialIndex.d.ts +1 -1
- package/dist/types/util/geometry.d.ts +4 -0
- package/dist/types/util/groups.d.ts +3 -0
- package/dist/types/util/hitDetection.d.ts +2 -2
- package/dist/types/util/partitionPoint.d.ts +1 -0
- package/dist/types/util/weakMemo.d.ts +1 -0
- package/dist/types/version.d.ts +1 -1
- package/dist/util/SpatialIndex.js +8 -5
- package/dist/util/edgeCurves.js +7 -4
- package/dist/util/geometry.js +3 -1
- package/dist/util/groups.js +10 -0
- package/dist/util/hitDetection.js +9 -6
- package/dist/util/partitionPoint.js +6 -0
- package/dist/util/weakMemo.js +6 -0
- package/dist/version.js +1 -1
- package/dist/viewport.js +19 -17
- package/dist/walkEncoding.js +18 -14
- package/dist/walkHighlight.js +19 -15
- package/dist/walkKey.js +9 -6
- package/package.json +2 -2
- package/dist/chunks/chunk-ZY2AFL4Y.js +0 -43
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@@ -255,7 +251,14 @@ function figureSvg(graph, layout, o = {}) {
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walkKeySvg(
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).markup,
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1
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import {
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2
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computeColorSchemeRange,
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} from "./chunk-
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} from "./chunk-2XEQR54X.js";
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6
6
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abgrToCssRgba
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7
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} from "./chunk-G2FD7S3C.js";
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@@ -11,7 +11,7 @@ function tubeMapNodeColors(graph, colorScheme, referenceRamp) {
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const range =
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+
const range = computeColorSchemeRange(graph, referenceRamp);
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15
15
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return new Map(
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16
16
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graph.nodes.map((node, index) => [
|
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node.id,
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@@ -2,13 +2,13 @@ import {
|
|
|
2
2
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LIFT_BACKDROP_CSS,
|
|
3
3
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computeColorSchemeRange,
|
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4
4
|
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|
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5
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} from "./chunk-
|
|
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+
} from "./chunk-2XEQR54X.js";
|
|
6
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import {
|
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7
7
|
abgrToCssRgba
|
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8
8
|
} from "./chunk-G2FD7S3C.js";
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|
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10
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} from "./chunk-
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} from "./chunk-RJWPJCIB.js";
|
|
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|
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13
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|
// src/referenceStrip.ts
|
|
14
14
|
var REFERENCE_STRIP_PX = 12;
|
|
@@ -21,7 +21,7 @@ function referenceStripBlocks(graph, {
|
|
|
21
21
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referenceRamp,
|
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22
22
|
walks
|
|
23
23
|
}) {
|
|
24
|
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const range =
|
|
24
|
+
const range = computeColorSchemeRange(graph, referenceRamp);
|
|
25
25
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|
|
26
26
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graph.nodes.forEach((node, index) => {
|
|
27
27
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|
|
@@ -0,0 +1,327 @@
|
|
|
1
|
+
import {
|
|
2
|
+
pathSteps
|
|
3
|
+
} from "./chunk-ZNJ4JAPT.js";
|
|
4
|
+
import {
|
|
5
|
+
pathOrigin
|
|
6
|
+
} from "./chunk-LGJBB5BP.js";
|
|
7
|
+
import {
|
|
8
|
+
PathVisitsBuilder
|
|
9
|
+
} from "./chunk-ZPZ7GNBT.js";
|
|
10
|
+
import {
|
|
11
|
+
isBackbone
|
|
12
|
+
} from "./chunk-RJWPJCIB.js";
|
|
13
|
+
import {
|
|
14
|
+
partitionPoint
|
|
15
|
+
} from "./chunk-HOAIOEI7.js";
|
|
16
|
+
|
|
17
|
+
// src/tubeMap/coarsen.ts
|
|
18
|
+
function readWalk(path, steps) {
|
|
19
|
+
const runs = [];
|
|
20
|
+
const open = () => ({ a: -Infinity, b: Infinity, detour: [], bp: 0 });
|
|
21
|
+
const gaps = [open()];
|
|
22
|
+
for (const { node, strand } of steps) {
|
|
23
|
+
const gap = gaps.at(-1);
|
|
24
|
+
const last = runs.at(-1);
|
|
25
|
+
if (isBackbone(node)) {
|
|
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const start = node.stable.start;
|
|
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|
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const end = start + node.length;
|
|
28
|
+
const inverted = strand !== (node.stable.strand ?? "+");
|
|
29
|
+
const joins = last !== void 0 && gap.detour.length === 0;
|
|
30
|
+
if (joins && !last.inverted && !inverted && last.end === start) {
|
|
31
|
+
last.end = end;
|
|
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|
+
} else if (joins && last.inverted && inverted && last.start === end) {
|
|
33
|
+
last.start = start;
|
|
34
|
+
} else {
|
|
35
|
+
runs.push({ start, end, inverted });
|
|
36
|
+
gaps.push(open());
|
|
37
|
+
}
|
|
38
|
+
} else {
|
|
39
|
+
gap.detour.push({ node, strand });
|
|
40
|
+
gap.bp += node.length;
|
|
41
|
+
}
|
|
42
|
+
}
|
|
43
|
+
runs.forEach((run, i) => {
|
|
44
|
+
gaps[i].b = run.start;
|
|
45
|
+
gaps[i + 1].a = run.end;
|
|
46
|
+
});
|
|
47
|
+
return { path, runs, gaps };
|
|
48
|
+
}
|
|
49
|
+
function isSmall(gap, sigma) {
|
|
50
|
+
return Number.isFinite(gap.a) && Number.isFinite(gap.b) && gap.b >= gap.a && Math.max(gap.b - gap.a, gap.bp) < sigma;
|
|
51
|
+
}
|
|
52
|
+
function strictlyInside(cuts, a, b) {
|
|
53
|
+
const i = partitionPoint(cuts.length, (j) => cuts[j] <= a);
|
|
54
|
+
return i < cuts.length && cuts[i] < b;
|
|
55
|
+
}
|
|
56
|
+
function referenceGaps(backbone) {
|
|
57
|
+
const cuts = /* @__PURE__ */ new Map();
|
|
58
|
+
for (let i = 1; i < backbone.length; i++) {
|
|
59
|
+
const prev = backbone[i - 1];
|
|
60
|
+
const node = backbone[i];
|
|
61
|
+
const end = prev.stable.start + prev.length;
|
|
62
|
+
if (end !== node.stable.start) {
|
|
63
|
+
cuts.set(end, "reference-gap");
|
|
64
|
+
cuts.set(node.stable.start, "reference-gap");
|
|
65
|
+
}
|
|
66
|
+
}
|
|
67
|
+
return cuts;
|
|
68
|
+
}
|
|
69
|
+
function findCuts(walks, sigma, cuts) {
|
|
70
|
+
const cut = (bp, cause) => {
|
|
71
|
+
if (Number.isFinite(bp) && !cuts.has(bp)) {
|
|
72
|
+
cuts.set(bp, cause);
|
|
73
|
+
}
|
|
74
|
+
};
|
|
75
|
+
for (const { runs, gaps } of walks) {
|
|
76
|
+
const first = runs[0];
|
|
77
|
+
const last = runs.at(-1);
|
|
78
|
+
if (first && last) {
|
|
79
|
+
cut(first.start, "walk-end");
|
|
80
|
+
cut(last.end, "walk-end");
|
|
81
|
+
}
|
|
82
|
+
for (const run of runs) {
|
|
83
|
+
if (run.inverted && run.end - run.start >= sigma) {
|
|
84
|
+
cut(run.start, "inversion");
|
|
85
|
+
cut(run.end, "inversion");
|
|
86
|
+
}
|
|
87
|
+
}
|
|
88
|
+
for (const gap of gaps) {
|
|
89
|
+
if (gap.b < gap.a) {
|
|
90
|
+
cut(gap.a, "backward");
|
|
91
|
+
cut(gap.b, "backward");
|
|
92
|
+
} else if (!isSmall(gap, sigma)) {
|
|
93
|
+
cut(gap.a, "variant");
|
|
94
|
+
cut(gap.b, "variant");
|
|
95
|
+
}
|
|
96
|
+
}
|
|
97
|
+
}
|
|
98
|
+
const spans = walks.flatMap(({ runs, gaps }) => [
|
|
99
|
+
...gaps.filter((g) => isSmall(g, sigma)).map((g) => [g.a, g.b]),
|
|
100
|
+
...runs.filter((r) => r.inverted && r.end - r.start < sigma).map((r) => [r.start, r.end])
|
|
101
|
+
]);
|
|
102
|
+
for (let changed = true; changed; ) {
|
|
103
|
+
changed = false;
|
|
104
|
+
const sorted = [...cuts.keys()].sort((x, y) => x - y);
|
|
105
|
+
for (const [a, b] of spans) {
|
|
106
|
+
if (strictlyInside(sorted, a, b)) {
|
|
107
|
+
changed ||= !cuts.has(a) || !cuts.has(b);
|
|
108
|
+
cut(a, "overlap");
|
|
109
|
+
cut(b, "overlap");
|
|
110
|
+
}
|
|
111
|
+
}
|
|
112
|
+
}
|
|
113
|
+
return cuts;
|
|
114
|
+
}
|
|
115
|
+
function mergeReference(backbone, cuts) {
|
|
116
|
+
const merged = [];
|
|
117
|
+
let group = [];
|
|
118
|
+
const close = () => {
|
|
119
|
+
const first = group[0];
|
|
120
|
+
const last = group.at(-1);
|
|
121
|
+
if (first && last) {
|
|
122
|
+
const bp0 = first.stable.start;
|
|
123
|
+
const bp1 = last.stable.start + last.length;
|
|
124
|
+
const name = `${bp0}-${bp1}`;
|
|
125
|
+
merged.push({
|
|
126
|
+
node: {
|
|
127
|
+
id: `${name}+`,
|
|
128
|
+
name,
|
|
129
|
+
length: bp1 - bp0,
|
|
130
|
+
depth: 0,
|
|
131
|
+
stable: {
|
|
132
|
+
refName: first.stable.refName,
|
|
133
|
+
start: bp0,
|
|
134
|
+
rank: 0,
|
|
135
|
+
strand: "+"
|
|
136
|
+
}
|
|
137
|
+
},
|
|
138
|
+
members: group
|
|
139
|
+
});
|
|
140
|
+
}
|
|
141
|
+
group = [];
|
|
142
|
+
};
|
|
143
|
+
for (const node of backbone) {
|
|
144
|
+
if (cuts.has(node.stable.start)) {
|
|
145
|
+
close();
|
|
146
|
+
}
|
|
147
|
+
group.push(node);
|
|
148
|
+
}
|
|
149
|
+
close();
|
|
150
|
+
return merged;
|
|
151
|
+
}
|
|
152
|
+
function lastAtMost(items, key, x) {
|
|
153
|
+
return Math.max(0, partitionPoint(items.length, (i) => key(items[i]) <= x) - 1);
|
|
154
|
+
}
|
|
155
|
+
function coarsenTubeMap(graph, sigma) {
|
|
156
|
+
const backbone = graph.nodes.filter(isBackbone).sort((a, b) => a.stable.start - b.stable.start);
|
|
157
|
+
const paths = graph.paths ?? [];
|
|
158
|
+
if (backbone.length === 0 || paths.length === 0) {
|
|
159
|
+
return void 0;
|
|
160
|
+
}
|
|
161
|
+
const stepsOf = pathSteps(graph);
|
|
162
|
+
const walks = paths.map((p, i) => readWalk(p, stepsOf[i]));
|
|
163
|
+
const cuts = findCuts(walks, sigma, referenceGaps(backbone));
|
|
164
|
+
const sortedCuts = [...cuts.keys()].sort((x, y) => x - y);
|
|
165
|
+
const merged = mergeReference(backbone, cuts);
|
|
166
|
+
const mergedAt = (bp) => lastAtMost(merged, (m) => m.node.stable.start, bp);
|
|
167
|
+
const members = /* @__PURE__ */ new Map();
|
|
168
|
+
const coarseOf = /* @__PURE__ */ new Map();
|
|
169
|
+
for (const m of merged) {
|
|
170
|
+
members.set(
|
|
171
|
+
m.node.id,
|
|
172
|
+
m.members.map((n) => n.id)
|
|
173
|
+
);
|
|
174
|
+
for (const n of m.members) {
|
|
175
|
+
coarseOf.set(n.id, m.node.id);
|
|
176
|
+
}
|
|
177
|
+
}
|
|
178
|
+
const routes = /* @__PURE__ */ new Map();
|
|
179
|
+
const routeFor = (gap) => {
|
|
180
|
+
const key = `${gap.a} ${gap.b} ${gap.detour.map((s) => s.node.id + s.strand).join(",")}`;
|
|
181
|
+
let node = routes.get(key);
|
|
182
|
+
if (!node) {
|
|
183
|
+
const name = `r${routes.size}`;
|
|
184
|
+
node = {
|
|
185
|
+
id: `${name}+`,
|
|
186
|
+
name,
|
|
187
|
+
length: gap.bp,
|
|
188
|
+
depth: 0,
|
|
189
|
+
stable: {
|
|
190
|
+
refName: backbone[0].stable.refName,
|
|
191
|
+
start: Number.isFinite(gap.a) ? gap.a : gap.b,
|
|
192
|
+
rank: 1,
|
|
193
|
+
strand: "+"
|
|
194
|
+
}
|
|
195
|
+
};
|
|
196
|
+
routes.set(key, node);
|
|
197
|
+
members.set(
|
|
198
|
+
node.id,
|
|
199
|
+
gap.detour.map((s) => s.node.id)
|
|
200
|
+
);
|
|
201
|
+
for (const s of gap.detour) {
|
|
202
|
+
if (!coarseOf.has(s.node.id)) {
|
|
203
|
+
coarseOf.set(s.node.id, node.id);
|
|
204
|
+
}
|
|
205
|
+
}
|
|
206
|
+
}
|
|
207
|
+
return node;
|
|
208
|
+
};
|
|
209
|
+
const deviations = /* @__PURE__ */ new Map();
|
|
210
|
+
const coarsePaths = [];
|
|
211
|
+
const pathVisits = new PathVisitsBuilder();
|
|
212
|
+
const edges = /* @__PURE__ */ new Map();
|
|
213
|
+
const depth = /* @__PURE__ */ new Map();
|
|
214
|
+
for (const { path, runs, gaps } of walks) {
|
|
215
|
+
const steps = [];
|
|
216
|
+
const devs = [];
|
|
217
|
+
let continuing = false;
|
|
218
|
+
const append = (node, strand) => {
|
|
219
|
+
const last = steps.at(-1);
|
|
220
|
+
if (!(continuing && last?.node === node && last.strand === strand)) {
|
|
221
|
+
steps.push({ node, strand });
|
|
222
|
+
}
|
|
223
|
+
continuing = true;
|
|
224
|
+
};
|
|
225
|
+
const structural = (gap) => {
|
|
226
|
+
continuing = false;
|
|
227
|
+
if (gap.detour.length > 0) {
|
|
228
|
+
append(routeFor(gap), "+");
|
|
229
|
+
continuing = false;
|
|
230
|
+
}
|
|
231
|
+
};
|
|
232
|
+
const fold = (gap) => {
|
|
233
|
+
if (gap.bp > 0 || gap.b > gap.a) {
|
|
234
|
+
devs.push({ start: gap.a, end: gap.b, bp: gap.bp });
|
|
235
|
+
}
|
|
236
|
+
const home = merged[mergedAt(gap.b > gap.a ? gap.a : gap.a - 1)];
|
|
237
|
+
for (const s of gap.detour) {
|
|
238
|
+
if (!coarseOf.has(s.node.id)) {
|
|
239
|
+
coarseOf.set(s.node.id, home.node.id);
|
|
240
|
+
members.get(home.node.id).push(s.node.id);
|
|
241
|
+
}
|
|
242
|
+
}
|
|
243
|
+
};
|
|
244
|
+
runs.forEach((run, i) => {
|
|
245
|
+
const gap = gaps[i];
|
|
246
|
+
if (isSmall(gap, sigma) && !strictlyInside(sortedCuts, gap.a, gap.b)) {
|
|
247
|
+
fold(gap);
|
|
248
|
+
} else {
|
|
249
|
+
structural(gap);
|
|
250
|
+
}
|
|
251
|
+
const i0 = mergedAt(run.start);
|
|
252
|
+
const i1 = mergedAt(run.end - 1);
|
|
253
|
+
const small = run.end - run.start < sigma;
|
|
254
|
+
if (run.inverted && !small) {
|
|
255
|
+
continuing = false;
|
|
256
|
+
for (let j = i1; j >= i0; j--) {
|
|
257
|
+
append(merged[j].node, "-");
|
|
258
|
+
}
|
|
259
|
+
continuing = false;
|
|
260
|
+
} else {
|
|
261
|
+
if (run.inverted) {
|
|
262
|
+
devs.push({
|
|
263
|
+
start: run.start,
|
|
264
|
+
end: run.end,
|
|
265
|
+
bp: run.end - run.start,
|
|
266
|
+
inverted: true
|
|
267
|
+
});
|
|
268
|
+
}
|
|
269
|
+
for (let j = i0; j <= i1; j++) {
|
|
270
|
+
append(merged[j].node, "+");
|
|
271
|
+
}
|
|
272
|
+
}
|
|
273
|
+
});
|
|
274
|
+
structural(gaps.at(-1));
|
|
275
|
+
const visitName = pathOrigin(path.name).name;
|
|
276
|
+
let pos = 0;
|
|
277
|
+
steps.forEach(({ node, strand }, i) => {
|
|
278
|
+
depth.set(node.id, (depth.get(node.id) ?? 0) + 1);
|
|
279
|
+
pathVisits.add(
|
|
280
|
+
node.name,
|
|
281
|
+
visitName,
|
|
282
|
+
path.sample ?? visitName,
|
|
283
|
+
pos,
|
|
284
|
+
strand === "-"
|
|
285
|
+
);
|
|
286
|
+
pos += node.length;
|
|
287
|
+
const next = steps[i + 1];
|
|
288
|
+
if (next) {
|
|
289
|
+
const key = `${node.id}${strand} ${next.node.id}${next.strand}`;
|
|
290
|
+
const edge = edges.get(key);
|
|
291
|
+
if (edge) {
|
|
292
|
+
edge.pathIds.push(path.name);
|
|
293
|
+
} else {
|
|
294
|
+
edges.set(key, {
|
|
295
|
+
from: node.id,
|
|
296
|
+
to: next.node.id,
|
|
297
|
+
fromStrand: strand,
|
|
298
|
+
toStrand: next.strand,
|
|
299
|
+
pathIds: [path.name]
|
|
300
|
+
});
|
|
301
|
+
}
|
|
302
|
+
}
|
|
303
|
+
});
|
|
304
|
+
coarsePaths.push({ ...path, nodeIds: steps.map((s) => s.node.id) });
|
|
305
|
+
deviations.set(path.name, devs);
|
|
306
|
+
}
|
|
307
|
+
const nodes = [...merged.map((m) => m.node), ...routes.values()].filter((n) => depth.has(n.id)).map((n) => ({ ...n, depth: depth.get(n.id) }));
|
|
308
|
+
return {
|
|
309
|
+
graph: {
|
|
310
|
+
...graph,
|
|
311
|
+
nodes,
|
|
312
|
+
edges: [...edges.values()],
|
|
313
|
+
paths: coarsePaths,
|
|
314
|
+
pathVisits: pathVisits.build(),
|
|
315
|
+
reads: void 0
|
|
316
|
+
},
|
|
317
|
+
members,
|
|
318
|
+
coarseOf,
|
|
319
|
+
deviations,
|
|
320
|
+
cuts
|
|
321
|
+
};
|
|
322
|
+
}
|
|
323
|
+
|
|
324
|
+
export {
|
|
325
|
+
lastAtMost,
|
|
326
|
+
coarsenTubeMap
|
|
327
|
+
};
|