@inflexa-ai/harness 0.35.8 → 0.36.0

package/dist/workflows/target-assessment/schemas.d.ts

@@ -1,970 +0,0 @@
-/**
- * Shared schemas for target-assessment workflow inter-step contracts.
- *
- * The workflow input/output schemas, the resolved-target shape used by
- * every Phase-1 collector, and the keyed Phase-1/2/3 bundle shapes.
- */
-import { z } from "zod";
-export declare const TargetAssessmentInputSchema: z.ZodObject<{
-    assessmentId: z.ZodString;
-    target: z.ZodString;
-    goal: z.ZodOptional<z.ZodNullable<z.ZodString>>;
-    organizationId: z.ZodString;
-    requestedBy: z.ZodString;
-}, z.core.$strip>;
-export declare const ResolvedTargetSchema: z.ZodObject<{
-    assessmentId: z.ZodString;
-    goal: z.ZodNullable<z.ZodString>;
-    canonicalId: z.ZodString;
-    canonicalOntology: z.ZodEnum<{
-        hgnc: "hgnc";
-        ensembl: "ensembl";
-    }>;
-    geneSymbol: z.ZodString;
-    approvedName: z.ZodString;
-    ids: z.ZodObject<{
-        hgnc: z.ZodNullable<z.ZodString>;
-        ensembl: z.ZodNullable<z.ZodString>;
-        uniprot: z.ZodNullable<z.ZodString>;
-        chembl: z.ZodNullable<z.ZodString>;
-        entrez: z.ZodNullable<z.ZodString>;
-    }, z.core.$strip>;
-    synonyms: z.ZodArray<z.ZodString>;
-    proteinSynonyms: z.ZodArray<z.ZodString>;
-    proteinFamily: z.ZodNullable<z.ZodString>;
-    resolutionCoverage: z.ZodObject<{
-        hgnc: z.ZodBoolean;
-        uniprot: z.ZodBoolean;
-        ensembl: z.ZodBoolean;
-        chembl: z.ZodBoolean;
-    }, z.core.$strip>;
-}, z.core.$strip>;
-export type ResolvedTarget = z.infer<typeof ResolvedTargetSchema>;
-export declare const OpenTargetsBundleSchema: z.ZodObject<{
-    ensemblId: z.ZodString;
-    approvedSymbol: z.ZodString;
-    approvedName: z.ZodString;
-    tractability: z.ZodNullable<z.ZodObject<{
-        smallMolecule: z.ZodNullable<z.ZodBoolean>;
-        antibody: z.ZodNullable<z.ZodBoolean>;
-        otherModalities: z.ZodNullable<z.ZodBoolean>;
-    }, z.core.$strip>>;
-    associations: z.ZodArray<z.ZodObject<{
-        diseaseId: z.ZodString;
-        diseaseName: z.ZodString;
-        score: z.ZodNumber;
-        geneticAssociationScore: z.ZodNullable<z.ZodNumber>;
-        knownDrugScore: z.ZodNullable<z.ZodNumber>;
-        literatureScore: z.ZodNullable<z.ZodNumber>;
-        animalModelScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
-        somaticMutationScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
-        literaturePmids: z.ZodDefault<z.ZodArray<z.ZodString>>;
-    }, z.core.$strip>>;
-    safetyLiabilities: z.ZodArray<z.ZodObject<{
-        event: z.ZodString;
-        biosamples: z.ZodArray<z.ZodString>;
-        effects: z.ZodNullable<z.ZodString>;
-        source: z.ZodString;
-    }, z.core.$strip>>;
-    baselineExpression: z.ZodArray<z.ZodObject<{
-        tissueId: z.ZodString;
-        tissueLabel: z.ZodString;
-        organSystem: z.ZodNullable<z.ZodString>;
-        datasourceId: z.ZodString;
-        rna: z.ZodNullable<z.ZodObject<{
-            value: z.ZodNumber;
-            unit: z.ZodString;
-        }, z.core.$strip>>;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type OpenTargetsBundle = z.infer<typeof OpenTargetsBundleSchema>;
-export declare const ChemblModulatorsBundleSchema: z.ZodObject<{
-    targetChemblId: z.ZodNullable<z.ZodString>;
-    modulators: z.ZodArray<z.ZodObject<{
-        moleculeChemblId: z.ZodString;
-        parentChemblId: z.ZodNullable<z.ZodString>;
-        preferredName: z.ZodNullable<z.ZodString>;
-        maxPhase: z.ZodNullable<z.ZodNumber>;
-        moleculeType: z.ZodNullable<z.ZodString>;
-        firstApproval: z.ZodNullable<z.ZodNumber>;
-        evidence_source: z.ZodOptional<z.ZodLiteral<"chembl_activity">>;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type ChemblModulatorsBundle = z.infer<typeof ChemblModulatorsBundleSchema>;
-export declare const CtgovInterventionSchema: z.ZodObject<{
-    name: z.ZodString;
-    type: z.ZodNullable<z.ZodString>;
-    description: z.ZodNullable<z.ZodString>;
-    otherNames: z.ZodArray<z.ZodString>;
-}, z.core.$strip>;
-export declare const CtgovTrialSchema: z.ZodObject<{
-    nctId: z.ZodString;
-    title: z.ZodString;
-    officialTitle: z.ZodNullable<z.ZodString>;
-    status: z.ZodString;
-    phase: z.ZodNullable<z.ZodString>;
-    studyType: z.ZodNullable<z.ZodString>;
-    primaryPurpose: z.ZodNullable<z.ZodString>;
-    conditions: z.ZodArray<z.ZodString>;
-    interventions: z.ZodArray<z.ZodString>;
-    interventionDetails: z.ZodArray<z.ZodObject<{
-        name: z.ZodString;
-        type: z.ZodNullable<z.ZodString>;
-        description: z.ZodNullable<z.ZodString>;
-        otherNames: z.ZodArray<z.ZodString>;
-    }, z.core.$strip>>;
-    enrollmentCount: z.ZodNullable<z.ZodNumber>;
-    startDate: z.ZodNullable<z.ZodString>;
-    primaryCompletionDate: z.ZodNullable<z.ZodString>;
-    whyStopped: z.ZodNullable<z.ZodString>;
-    briefSummary: z.ZodNullable<z.ZodString>;
-    detailedDescription: z.ZodNullable<z.ZodString>;
-    sponsor: z.ZodNullable<z.ZodString>;
-    collection_query: z.ZodOptional<z.ZodString>;
-    collection_channel: z.ZodOptional<z.ZodEnum<{
-        class_modulator: "class_modulator";
-        target_symbol: "target_symbol";
-        therapeutic_program: "therapeutic_program";
-        biomarker_context: "biomarker_context";
-        failed_intervention: "failed_intervention";
-    }>>;
-}, z.core.$strip>;
-export declare const CtgovBundleSchema: z.ZodObject<{
-    active: z.ZodArray<z.ZodObject<{
-        nctId: z.ZodString;
-        title: z.ZodString;
-        officialTitle: z.ZodNullable<z.ZodString>;
-        status: z.ZodString;
-        phase: z.ZodNullable<z.ZodString>;
-        studyType: z.ZodNullable<z.ZodString>;
-        primaryPurpose: z.ZodNullable<z.ZodString>;
-        conditions: z.ZodArray<z.ZodString>;
-        interventions: z.ZodArray<z.ZodString>;
-        interventionDetails: z.ZodArray<z.ZodObject<{
-            name: z.ZodString;
-            type: z.ZodNullable<z.ZodString>;
-            description: z.ZodNullable<z.ZodString>;
-            otherNames: z.ZodArray<z.ZodString>;
-        }, z.core.$strip>>;
-        enrollmentCount: z.ZodNullable<z.ZodNumber>;
-        startDate: z.ZodNullable<z.ZodString>;
-        primaryCompletionDate: z.ZodNullable<z.ZodString>;
-        whyStopped: z.ZodNullable<z.ZodString>;
-        briefSummary: z.ZodNullable<z.ZodString>;
-        detailedDescription: z.ZodNullable<z.ZodString>;
-        sponsor: z.ZodNullable<z.ZodString>;
-        collection_query: z.ZodOptional<z.ZodString>;
-        collection_channel: z.ZodOptional<z.ZodEnum<{
-            class_modulator: "class_modulator";
-            target_symbol: "target_symbol";
-            therapeutic_program: "therapeutic_program";
-            biomarker_context: "biomarker_context";
-            failed_intervention: "failed_intervention";
-        }>>;
-    }, z.core.$strip>>;
-    failed: z.ZodArray<z.ZodObject<{
-        nctId: z.ZodString;
-        title: z.ZodString;
-        officialTitle: z.ZodNullable<z.ZodString>;
-        status: z.ZodString;
-        phase: z.ZodNullable<z.ZodString>;
-        studyType: z.ZodNullable<z.ZodString>;
-        primaryPurpose: z.ZodNullable<z.ZodString>;
-        conditions: z.ZodArray<z.ZodString>;
-        interventions: z.ZodArray<z.ZodString>;
-        interventionDetails: z.ZodArray<z.ZodObject<{
-            name: z.ZodString;
-            type: z.ZodNullable<z.ZodString>;
-            description: z.ZodNullable<z.ZodString>;
-            otherNames: z.ZodArray<z.ZodString>;
-        }, z.core.$strip>>;
-        enrollmentCount: z.ZodNullable<z.ZodNumber>;
-        startDate: z.ZodNullable<z.ZodString>;
-        primaryCompletionDate: z.ZodNullable<z.ZodString>;
-        whyStopped: z.ZodNullable<z.ZodString>;
-        briefSummary: z.ZodNullable<z.ZodString>;
-        detailedDescription: z.ZodNullable<z.ZodString>;
-        sponsor: z.ZodNullable<z.ZodString>;
-        collection_query: z.ZodOptional<z.ZodString>;
-        collection_channel: z.ZodOptional<z.ZodEnum<{
-            class_modulator: "class_modulator";
-            target_symbol: "target_symbol";
-            therapeutic_program: "therapeutic_program";
-            biomarker_context: "biomarker_context";
-            failed_intervention: "failed_intervention";
-        }>>;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type CtgovBundle = z.infer<typeof CtgovBundleSchema>;
-export declare const FaersByTargetBundleSchema: z.ZodObject<{
-    drugProbed: z.ZodString;
-    totalReports: z.ZodNullable<z.ZodNumber>;
-    topReactions: z.ZodArray<z.ZodObject<{
-        reaction: z.ZodString;
-        count: z.ZodNumber;
-    }, z.core.$strip>>;
-    seriousness: z.ZodNullable<z.ZodObject<{
-        totalReports: z.ZodNumber;
-        fatalCount: z.ZodNumber;
-        hospitalizationCount: z.ZodNumber;
-        lifeThreateningCount: z.ZodNumber;
-        disablingCount: z.ZodNumber;
-        congenitalAnomalyCount: z.ZodDefault<z.ZodNumber>;
-        otherSeriousCount: z.ZodDefault<z.ZodNumber>;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type FaersByTargetBundle = z.infer<typeof FaersByTargetBundleSchema>;
-export declare const ExpressionHumanBundleSchema: z.ZodObject<{
-    source: z.ZodEnum<{
-        gtex: "gtex";
-        hpa_consensus: "hpa_consensus";
-        hpa_rna_tissue: "hpa_rna_tissue";
-    }>;
-    unit: z.ZodEnum<{
-        tpm: "tpm";
-        ntpm: "ntpm";
-        consensus_normalized: "consensus_normalized";
-    }>;
-    normalization_notes: z.ZodString;
-    tissues: z.ZodArray<z.ZodObject<{
-        tissueLabel: z.ZodString;
-        organSystem: z.ZodNullable<z.ZodString>;
-        value: z.ZodNullable<z.ZodNumber>;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type ExpressionHumanBundle = z.infer<typeof ExpressionHumanBundleSchema>;
-export declare const ExpressionMultiSpeciesBundleSchema: z.ZodObject<{
-    geneSymbol: z.ZodString;
-    humanEnsemblId: z.ZodNullable<z.ZodString>;
-    bySpecies: z.ZodArray<z.ZodObject<{
-        species: z.ZodString;
-        taxonId: z.ZodNumber;
-        ensemblId: z.ZodString;
-        source: z.ZodString;
-        unit: z.ZodString;
-        normalization_notes: z.ZodString;
-        tissues: z.ZodArray<z.ZodObject<{
-            tissue: z.ZodString;
-            rank: z.ZodEnum<{
-                low: "low";
-                medium: "medium";
-                high: "high";
-                absent: "absent";
-            }>;
-            expressionScore: z.ZodNullable<z.ZodNumber>;
-        }, z.core.$strip>>;
-    }, z.core.$strip>>;
-    notFound: z.ZodArray<z.ZodString>;
-}, z.core.$strip>;
-export type ExpressionMultiSpeciesBundle = z.infer<typeof ExpressionMultiSpeciesBundleSchema>;
-export declare const ClinvarBundleSchema: z.ZodObject<{
-    totalFound: z.ZodNumber;
-    variants: z.ZodArray<z.ZodObject<{
-        variationId: z.ZodString;
-        title: z.ZodString;
-        clinicalSignificance: z.ZodString;
-        reviewStatus: z.ZodString;
-        conditions: z.ZodArray<z.ZodString>;
-        molecularConsequence: z.ZodString;
-        accession: z.ZodString;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type ClinvarBundle = z.infer<typeof ClinvarBundleSchema>;
-export declare const CbioportalBundleSchema: z.ZodObject<{
-    entrezGeneId: z.ZodNullable<z.ZodNumber>;
-    rows: z.ZodArray<z.ZodObject<{
-        cancerTypeId: z.ZodString;
-        cancerTypeName: z.ZodString;
-        totalSamples: z.ZodNumber;
-        mutatedSamples: z.ZodNumber;
-        frequency: z.ZodNumber;
-        studies: z.ZodArray<z.ZodString>;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type CbioportalBundle = z.infer<typeof CbioportalBundleSchema>;
-export declare const ImpcBundleSchema: z.ZodObject<{
-    mouseMarkerSymbol: z.ZodNullable<z.ZodString>;
-    mgiAccessionId: z.ZodNullable<z.ZodString>;
-    viability: z.ZodNullable<z.ZodEnum<{
-        lethal_pre_weaning: "lethal_pre_weaning";
-        subviable: "subviable";
-        viable: "viable";
-    }>>;
-    viabilityCalls: z.ZodArray<z.ZodObject<{
-        zygosity: z.ZodString;
-        parameterStableId: z.ZodString;
-        mpTerm: z.ZodNullable<z.ZodObject<{
-            id: z.ZodString;
-            name: z.ZodString;
-        }, z.core.$strip>>;
-    }, z.core.$strip>>;
-    mpTerms: z.ZodArray<z.ZodObject<{
-        id: z.ZodString;
-        term: z.ZodString;
-        bestPValue: z.ZodNullable<z.ZodNumber>;
-    }, z.core.$strip>>;
-    organSystems: z.ZodArray<z.ZodString>;
-    sexDimorphic: z.ZodBoolean;
-    phenotypeCount: z.ZodNumber;
-}, z.core.$strip>;
-export type ImpcBundle = z.infer<typeof ImpcBundleSchema>;
-export declare const PubmedIndexBundleSchema: z.ZodObject<{
-    totalFound: z.ZodNumber;
-    topPmids: z.ZodArray<z.ZodString>;
-    results: z.ZodArray<z.ZodObject<{
-        pmid: z.ZodString;
-        title: z.ZodString;
-        journal: z.ZodString;
-        year: z.ZodString;
-        authors: z.ZodString;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type PubmedIndexBundle = z.infer<typeof PubmedIndexBundleSchema>;
-export declare const PathwaysBundleSchema: z.ZodObject<{
-    pathways: z.ZodArray<z.ZodObject<{
-        id: z.ZodString;
-        name: z.ZodString;
-        source: z.ZodEnum<{
-            kegg: "kegg";
-            reactome: "reactome";
-        }>;
-        url: z.ZodOptional<z.ZodString>;
-        entity_uniprots: z.ZodOptional<z.ZodArray<z.ZodString>>;
-        metadata: z.ZodOptional<z.ZodObject<{
-            species_present: z.ZodOptional<z.ZodArray<z.ZodString>>;
-        }, z.core.$strip>>;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type PathwaysBundle = z.infer<typeof PathwaysBundleSchema>;
-export declare const StringPpiBundleSchema: z.ZodObject<{
-    partners: z.ZodArray<z.ZodObject<{
-        proteinA: z.ZodString;
-        proteinB: z.ZodString;
-        score: z.ZodNumber;
-        experimentalScore: z.ZodOptional<z.ZodNumber>;
-        databaseScore: z.ZodOptional<z.ZodNumber>;
-        textminingScore: z.ZodOptional<z.ZodNumber>;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type StringPpiBundle = z.infer<typeof StringPpiBundleSchema>;
-/**
- * Heterodimer / receptor-accessory complex inventory for the assessment
- * target, sourced from IUPHAR Guide to Pharmacology. Drives runtime
- * heterodimer-name detection (no hardcoded RAMP/MRAP/RGS regex) and the
- * obligate-cofactor supplement in the off-target panel.
- */
-export declare const FamilyComplexesBundleSchema: z.ZodObject<{
-    primaryTargetGene: z.ZodString;
-    primaryTargetUniprot: z.ZodNullable<z.ZodString>;
-    accessoryProteinNames: z.ZodArray<z.ZodString>;
-    complexes: z.ZodArray<z.ZodObject<{
-        complexName: z.ZodString;
-        complexId: z.ZodNullable<z.ZodNumber>;
-        accessoryNames: z.ZodArray<z.ZodString>;
-        subunitNames: z.ZodArray<z.ZodString>;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type FamilyComplexesBundle = z.infer<typeof FamilyComplexesBundleSchema>;
-export declare const TherapeuticProgramsBundleSchema: z.ZodObject<{
-    programs: z.ZodArray<z.ZodObject<{
-        programId: z.ZodString;
-        name: z.ZodString;
-        targetSymbol: z.ZodString;
-        targetUniprot: z.ZodNullable<z.ZodString>;
-        modality: z.ZodString;
-        sponsor: z.ZodNullable<z.ZodString>;
-        mechanism: z.ZodString;
-        status: z.ZodString;
-        nctIds: z.ZodArray<z.ZodString>;
-        pmids: z.ZodArray<z.ZodString>;
-        evidence: z.ZodArray<z.ZodObject<{
-            pmid: z.ZodOptional<z.ZodString>;
-            doi: z.ZodOptional<z.ZodString>;
-            accession: z.ZodOptional<z.ZodString>;
-            source: z.ZodString;
-            predicate: z.ZodOptional<z.ZodString>;
-            score: z.ZodOptional<z.ZodNumber>;
-            strength: z.ZodOptional<z.ZodString>;
-            is_human: z.ZodOptional<z.ZodBoolean>;
-            is_clinical: z.ZodOptional<z.ZodBoolean>;
-            excerpt: z.ZodOptional<z.ZodString>;
-            metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
-            regulatory_reference: z.ZodOptional<z.ZodObject<{
-                document: z.ZodString;
-                section: z.ZodOptional<z.ZodString>;
-                doc_id: z.ZodOptional<z.ZodString>;
-                doc_url: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>>;
-        confidence: z.ZodEnum<{
-            low: "low";
-            medium: "medium";
-            high: "high";
-        }>;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type TherapeuticProgramsBundle = z.infer<typeof TherapeuticProgramsBundleSchema>;
-/**
- * Curated human phenotype and causal-disease evidence from Monarch.
- *
- * `ancestorIds` is the HPO ancestor closure, carried through so the consumer
- * resolves a phenotype onto an organ by identifier rather than by its label.
- */
-export declare const MonarchBundleSchema: z.ZodObject<{
-    geneCurie: z.ZodString;
-    phenotypes: z.ZodArray<z.ZodObject<{
-        hpoId: z.ZodString;
-        label: z.ZodString;
-        ancestorIds: z.ZodArray<z.ZodString>;
-        publications: z.ZodArray<z.ZodString>;
-        diseaseContext: z.ZodNullable<z.ZodString>;
-        frequencyPercent: z.ZodNullable<z.ZodNumber>;
-        primaryKnowledgeSource: z.ZodNullable<z.ZodString>;
-    }, z.core.$strip>>;
-}, z.core.$strip>;
-export type MonarchBundle = z.infer<typeof MonarchBundleSchema>;
-export declare const Phase1BundleSchema: z.ZodObject<{
-    resolved: z.ZodObject<{
-        assessmentId: z.ZodString;
-        goal: z.ZodNullable<z.ZodString>;
-        canonicalId: z.ZodString;
-        canonicalOntology: z.ZodEnum<{
-            hgnc: "hgnc";
-            ensembl: "ensembl";
-        }>;
-        geneSymbol: z.ZodString;
-        approvedName: z.ZodString;
-        ids: z.ZodObject<{
-            hgnc: z.ZodNullable<z.ZodString>;
-            ensembl: z.ZodNullable<z.ZodString>;
-            uniprot: z.ZodNullable<z.ZodString>;
-            chembl: z.ZodNullable<z.ZodString>;
-            entrez: z.ZodNullable<z.ZodString>;
-        }, z.core.$strip>;
-        synonyms: z.ZodArray<z.ZodString>;
-        proteinSynonyms: z.ZodArray<z.ZodString>;
-        proteinFamily: z.ZodNullable<z.ZodString>;
-        resolutionCoverage: z.ZodObject<{
-            hgnc: z.ZodBoolean;
-            uniprot: z.ZodBoolean;
-            ensembl: z.ZodBoolean;
-            chembl: z.ZodBoolean;
-        }, z.core.$strip>;
-    }, z.core.$strip>;
-    collectors: z.ZodObject<{
-        opentargets: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                ensemblId: z.ZodString;
-                approvedSymbol: z.ZodString;
-                approvedName: z.ZodString;
-                tractability: z.ZodNullable<z.ZodObject<{
-                    smallMolecule: z.ZodNullable<z.ZodBoolean>;
-                    antibody: z.ZodNullable<z.ZodBoolean>;
-                    otherModalities: z.ZodNullable<z.ZodBoolean>;
-                }, z.core.$strip>>;
-                associations: z.ZodArray<z.ZodObject<{
-                    diseaseId: z.ZodString;
-                    diseaseName: z.ZodString;
-                    score: z.ZodNumber;
-                    geneticAssociationScore: z.ZodNullable<z.ZodNumber>;
-                    knownDrugScore: z.ZodNullable<z.ZodNumber>;
-                    literatureScore: z.ZodNullable<z.ZodNumber>;
-                    animalModelScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
-                    somaticMutationScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
-                    literaturePmids: z.ZodDefault<z.ZodArray<z.ZodString>>;
-                }, z.core.$strip>>;
-                safetyLiabilities: z.ZodArray<z.ZodObject<{
-                    event: z.ZodString;
-                    biosamples: z.ZodArray<z.ZodString>;
-                    effects: z.ZodNullable<z.ZodString>;
-                    source: z.ZodString;
-                }, z.core.$strip>>;
-                baselineExpression: z.ZodArray<z.ZodObject<{
-                    tissueId: z.ZodString;
-                    tissueLabel: z.ZodString;
-                    organSystem: z.ZodNullable<z.ZodString>;
-                    datasourceId: z.ZodString;
-                    rna: z.ZodNullable<z.ZodObject<{
-                        value: z.ZodNumber;
-                        unit: z.ZodString;
-                    }, z.core.$strip>>;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        chemblModulators: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                targetChemblId: z.ZodNullable<z.ZodString>;
-                modulators: z.ZodArray<z.ZodObject<{
-                    moleculeChemblId: z.ZodString;
-                    parentChemblId: z.ZodNullable<z.ZodString>;
-                    preferredName: z.ZodNullable<z.ZodString>;
-                    maxPhase: z.ZodNullable<z.ZodNumber>;
-                    moleculeType: z.ZodNullable<z.ZodString>;
-                    firstApproval: z.ZodNullable<z.ZodNumber>;
-                    evidence_source: z.ZodOptional<z.ZodLiteral<"chembl_activity">>;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        ctgov: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                active: z.ZodArray<z.ZodObject<{
-                    nctId: z.ZodString;
-                    title: z.ZodString;
-                    officialTitle: z.ZodNullable<z.ZodString>;
-                    status: z.ZodString;
-                    phase: z.ZodNullable<z.ZodString>;
-                    studyType: z.ZodNullable<z.ZodString>;
-                    primaryPurpose: z.ZodNullable<z.ZodString>;
-                    conditions: z.ZodArray<z.ZodString>;
-                    interventions: z.ZodArray<z.ZodString>;
-                    interventionDetails: z.ZodArray<z.ZodObject<{
-                        name: z.ZodString;
-                        type: z.ZodNullable<z.ZodString>;
-                        description: z.ZodNullable<z.ZodString>;
-                        otherNames: z.ZodArray<z.ZodString>;
-                    }, z.core.$strip>>;
-                    enrollmentCount: z.ZodNullable<z.ZodNumber>;
-                    startDate: z.ZodNullable<z.ZodString>;
-                    primaryCompletionDate: z.ZodNullable<z.ZodString>;
-                    whyStopped: z.ZodNullable<z.ZodString>;
-                    briefSummary: z.ZodNullable<z.ZodString>;
-                    detailedDescription: z.ZodNullable<z.ZodString>;
-                    sponsor: z.ZodNullable<z.ZodString>;
-                    collection_query: z.ZodOptional<z.ZodString>;
-                    collection_channel: z.ZodOptional<z.ZodEnum<{
-                        class_modulator: "class_modulator";
-                        target_symbol: "target_symbol";
-                        therapeutic_program: "therapeutic_program";
-                        biomarker_context: "biomarker_context";
-                        failed_intervention: "failed_intervention";
-                    }>>;
-                }, z.core.$strip>>;
-                failed: z.ZodArray<z.ZodObject<{
-                    nctId: z.ZodString;
-                    title: z.ZodString;
-                    officialTitle: z.ZodNullable<z.ZodString>;
-                    status: z.ZodString;
-                    phase: z.ZodNullable<z.ZodString>;
-                    studyType: z.ZodNullable<z.ZodString>;
-                    primaryPurpose: z.ZodNullable<z.ZodString>;
-                    conditions: z.ZodArray<z.ZodString>;
-                    interventions: z.ZodArray<z.ZodString>;
-                    interventionDetails: z.ZodArray<z.ZodObject<{
-                        name: z.ZodString;
-                        type: z.ZodNullable<z.ZodString>;
-                        description: z.ZodNullable<z.ZodString>;
-                        otherNames: z.ZodArray<z.ZodString>;
-                    }, z.core.$strip>>;
-                    enrollmentCount: z.ZodNullable<z.ZodNumber>;
-                    startDate: z.ZodNullable<z.ZodString>;
-                    primaryCompletionDate: z.ZodNullable<z.ZodString>;
-                    whyStopped: z.ZodNullable<z.ZodString>;
-                    briefSummary: z.ZodNullable<z.ZodString>;
-                    detailedDescription: z.ZodNullable<z.ZodString>;
-                    sponsor: z.ZodNullable<z.ZodString>;
-                    collection_query: z.ZodOptional<z.ZodString>;
-                    collection_channel: z.ZodOptional<z.ZodEnum<{
-                        class_modulator: "class_modulator";
-                        target_symbol: "target_symbol";
-                        therapeutic_program: "therapeutic_program";
-                        biomarker_context: "biomarker_context";
-                        failed_intervention: "failed_intervention";
-                    }>>;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        faersByTarget: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                drugProbed: z.ZodString;
-                totalReports: z.ZodNullable<z.ZodNumber>;
-                topReactions: z.ZodArray<z.ZodObject<{
-                    reaction: z.ZodString;
-                    count: z.ZodNumber;
-                }, z.core.$strip>>;
-                seriousness: z.ZodNullable<z.ZodObject<{
-                    totalReports: z.ZodNumber;
-                    fatalCount: z.ZodNumber;
-                    hospitalizationCount: z.ZodNumber;
-                    lifeThreateningCount: z.ZodNumber;
-                    disablingCount: z.ZodNumber;
-                    congenitalAnomalyCount: z.ZodDefault<z.ZodNumber>;
-                    otherSeriousCount: z.ZodDefault<z.ZodNumber>;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        expressionHuman: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                source: z.ZodEnum<{
-                    gtex: "gtex";
-                    hpa_consensus: "hpa_consensus";
-                    hpa_rna_tissue: "hpa_rna_tissue";
-                }>;
-                unit: z.ZodEnum<{
-                    tpm: "tpm";
-                    ntpm: "ntpm";
-                    consensus_normalized: "consensus_normalized";
-                }>;
-                normalization_notes: z.ZodString;
-                tissues: z.ZodArray<z.ZodObject<{
-                    tissueLabel: z.ZodString;
-                    organSystem: z.ZodNullable<z.ZodString>;
-                    value: z.ZodNullable<z.ZodNumber>;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        expressionMultiSpecies: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                geneSymbol: z.ZodString;
-                humanEnsemblId: z.ZodNullable<z.ZodString>;
-                bySpecies: z.ZodArray<z.ZodObject<{
-                    species: z.ZodString;
-                    taxonId: z.ZodNumber;
-                    ensemblId: z.ZodString;
-                    source: z.ZodString;
-                    unit: z.ZodString;
-                    normalization_notes: z.ZodString;
-                    tissues: z.ZodArray<z.ZodObject<{
-                        tissue: z.ZodString;
-                        rank: z.ZodEnum<{
-                            low: "low";
-                            medium: "medium";
-                            high: "high";
-                            absent: "absent";
-                        }>;
-                        expressionScore: z.ZodNullable<z.ZodNumber>;
-                    }, z.core.$strip>>;
-                }, z.core.$strip>>;
-                notFound: z.ZodArray<z.ZodString>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        clinvar: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                totalFound: z.ZodNumber;
-                variants: z.ZodArray<z.ZodObject<{
-                    variationId: z.ZodString;
-                    title: z.ZodString;
-                    clinicalSignificance: z.ZodString;
-                    reviewStatus: z.ZodString;
-                    conditions: z.ZodArray<z.ZodString>;
-                    molecularConsequence: z.ZodString;
-                    accession: z.ZodString;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        cbioportal: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                entrezGeneId: z.ZodNullable<z.ZodNumber>;
-                rows: z.ZodArray<z.ZodObject<{
-                    cancerTypeId: z.ZodString;
-                    cancerTypeName: z.ZodString;
-                    totalSamples: z.ZodNumber;
-                    mutatedSamples: z.ZodNumber;
-                    frequency: z.ZodNumber;
-                    studies: z.ZodArray<z.ZodString>;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        impc: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                mouseMarkerSymbol: z.ZodNullable<z.ZodString>;
-                mgiAccessionId: z.ZodNullable<z.ZodString>;
-                viability: z.ZodNullable<z.ZodEnum<{
-                    lethal_pre_weaning: "lethal_pre_weaning";
-                    subviable: "subviable";
-                    viable: "viable";
-                }>>;
-                viabilityCalls: z.ZodArray<z.ZodObject<{
-                    zygosity: z.ZodString;
-                    parameterStableId: z.ZodString;
-                    mpTerm: z.ZodNullable<z.ZodObject<{
-                        id: z.ZodString;
-                        name: z.ZodString;
-                    }, z.core.$strip>>;
-                }, z.core.$strip>>;
-                mpTerms: z.ZodArray<z.ZodObject<{
-                    id: z.ZodString;
-                    term: z.ZodString;
-                    bestPValue: z.ZodNullable<z.ZodNumber>;
-                }, z.core.$strip>>;
-                organSystems: z.ZodArray<z.ZodString>;
-                sexDimorphic: z.ZodBoolean;
-                phenotypeCount: z.ZodNumber;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        pubmedIndex: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                totalFound: z.ZodNumber;
-                topPmids: z.ZodArray<z.ZodString>;
-                results: z.ZodArray<z.ZodObject<{
-                    pmid: z.ZodString;
-                    title: z.ZodString;
-                    journal: z.ZodString;
-                    year: z.ZodString;
-                    authors: z.ZodString;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        pathways: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                pathways: z.ZodArray<z.ZodObject<{
-                    id: z.ZodString;
-                    name: z.ZodString;
-                    source: z.ZodEnum<{
-                        kegg: "kegg";
-                        reactome: "reactome";
-                    }>;
-                    url: z.ZodOptional<z.ZodString>;
-                    entity_uniprots: z.ZodOptional<z.ZodArray<z.ZodString>>;
-                    metadata: z.ZodOptional<z.ZodObject<{
-                        species_present: z.ZodOptional<z.ZodArray<z.ZodString>>;
-                    }, z.core.$strip>>;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        stringPpi: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                partners: z.ZodArray<z.ZodObject<{
-                    proteinA: z.ZodString;
-                    proteinB: z.ZodString;
-                    score: z.ZodNumber;
-                    experimentalScore: z.ZodOptional<z.ZodNumber>;
-                    databaseScore: z.ZodOptional<z.ZodNumber>;
-                    textminingScore: z.ZodOptional<z.ZodNumber>;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        familyComplexes: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                primaryTargetGene: z.ZodString;
-                primaryTargetUniprot: z.ZodNullable<z.ZodString>;
-                accessoryProteinNames: z.ZodArray<z.ZodString>;
-                complexes: z.ZodArray<z.ZodObject<{
-                    complexName: z.ZodString;
-                    complexId: z.ZodNullable<z.ZodNumber>;
-                    accessoryNames: z.ZodArray<z.ZodString>;
-                    subunitNames: z.ZodArray<z.ZodString>;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        monarch: z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                geneCurie: z.ZodString;
-                phenotypes: z.ZodArray<z.ZodObject<{
-                    hpoId: z.ZodString;
-                    label: z.ZodString;
-                    ancestorIds: z.ZodArray<z.ZodString>;
-                    publications: z.ZodArray<z.ZodString>;
-                    diseaseContext: z.ZodNullable<z.ZodString>;
-                    frequencyPercent: z.ZodNullable<z.ZodNumber>;
-                    primaryKnowledgeSource: z.ZodNullable<z.ZodString>;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">;
-        therapeuticPrograms: z.ZodOptional<z.ZodDiscriminatedUnion<[z.ZodObject<{
-            coverage: z.ZodLiteral<"available">;
-            data: z.ZodObject<{
-                programs: z.ZodArray<z.ZodObject<{
-                    programId: z.ZodString;
-                    name: z.ZodString;
-                    targetSymbol: z.ZodString;
-                    targetUniprot: z.ZodNullable<z.ZodString>;
-                    modality: z.ZodString;
-                    sponsor: z.ZodNullable<z.ZodString>;
-                    mechanism: z.ZodString;
-                    status: z.ZodString;
-                    nctIds: z.ZodArray<z.ZodString>;
-                    pmids: z.ZodArray<z.ZodString>;
-                    evidence: z.ZodArray<z.ZodObject<{
-                        pmid: z.ZodOptional<z.ZodString>;
-                        doi: z.ZodOptional<z.ZodString>;
-                        accession: z.ZodOptional<z.ZodString>;
-                        source: z.ZodString;
-                        predicate: z.ZodOptional<z.ZodString>;
-                        score: z.ZodOptional<z.ZodNumber>;
-                        strength: z.ZodOptional<z.ZodString>;
-                        is_human: z.ZodOptional<z.ZodBoolean>;
-                        is_clinical: z.ZodOptional<z.ZodBoolean>;
-                        excerpt: z.ZodOptional<z.ZodString>;
-                        metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
-                        regulatory_reference: z.ZodOptional<z.ZodObject<{
-                            document: z.ZodString;
-                            section: z.ZodOptional<z.ZodString>;
-                            doc_id: z.ZodOptional<z.ZodString>;
-                            doc_url: z.ZodOptional<z.ZodString>;
-                        }, z.core.$strip>>;
-                    }, z.core.$strip>>;
-                    confidence: z.ZodEnum<{
-                        low: "low";
-                        medium: "medium";
-                        high: "high";
-                    }>;
-                }, z.core.$strip>>;
-            }, z.core.$strip>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"queried_no_data">;
-            error: z.ZodOptional<z.ZodObject<{
-                message: z.ZodString;
-                name: z.ZodOptional<z.ZodString>;
-                stack: z.ZodOptional<z.ZodString>;
-            }, z.core.$strip>>;
-        }, z.core.$strip>, z.ZodObject<{
-            coverage: z.ZodLiteral<"not_loaded">;
-            reason: z.ZodOptional<z.ZodString>;
-        }, z.core.$strip>], "coverage">>;
-    }, z.core.$strip>;
-}, z.core.$strip>;
-export type Phase1Bundle = z.infer<typeof Phase1BundleSchema>;