@genome-spy/core 0.60.0 → 0.60.1
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
package/dist/bundle/index.js
CHANGED
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@@ -20,7 +20,7 @@
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\r]`),n=t.charCodeAt(0);function r(f,d){var h,p,b=o(f,function(v,y){if(h)return h(v,y-1);p=v,h=d?gA(v,d):rp(v)});return b.columns=p||[],b}function o(f,d){var h=[],p=f.length,b=0,v=0,y,A=p<=0,S=!1;f.charCodeAt(p-1)===ds&&--p,f.charCodeAt(p-1)===Bu&&--p;function E(){if(A)return Tu;if(S)return S=!1,np;var _,B=b,N;if(f.charCodeAt(B)===Du){for(;b++<p&&f.charCodeAt(b)!==Du||f.charCodeAt(++b)===Du;);return(_=b)>=p?A=!0:(N=f.charCodeAt(b++))===ds?S=!0:N===Bu&&(S=!0,f.charCodeAt(b)===ds&&++b),f.slice(B+1,_-1).replace(/""/g,'"')}for(;b<p;){if((N=f.charCodeAt(_=b++))===ds)S=!0;else if(N===Bu)S=!0,f.charCodeAt(b)===ds&&++b;else if(N!==n)continue;return f.slice(B,_)}return A=!0,f.slice(B,p)}for(;(y=E())!==Tu;){for(var I=[];y!==np&&y!==Tu;)I.push(y),y=E();d&&(I=d(I,v++))==null||h.push(I)}return h}function i(f,d){return f.map(function(h){return d.map(function(p){return u(h[p])}).join(t)})}function s(f,d){return d==null&&(d=ip(f)),[d.map(u).join(t)].concat(i(f,d)).join(`
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`)}function a(f,d){return d==null&&(d=ip(f)),i(f,d).join(`
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* @license
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* Copyright 2017 Google LLC
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@@ -271,7 +271,7 @@ fragColor=vFillColor;if(uPickingEnabled){fragColor=vPickingColor;}
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}`,R6=`layout(std140)uniform Mark{uniform float uMinWidth;uniform float uMinHeight;uniform float uMinOpacity;uniform float uCornerRadiusTopRight;uniform float uCornerRadiusBottomRight;uniform float uCornerRadiusTopLeft;uniform float uCornerRadiusBottomLeft;uniform int uHatchPattern;uniform vec3 uShadowColor;uniform float uShadowOpacity;uniform float uShadowBlur;uniform float uShadowOffsetX;uniform float uShadowOffsetY;
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@@ -344,7 +344,7 @@ return function unrolledUpdateFromDatum(datum) {
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${n}
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};`)(this)}else this.updateFromDatum=e=>{for(let n=0;n<this.dataUpdaters.length;n++)this.dataUpdaters[n](e)}};const fa=5,_h=127;function Rh(t){const e=[];for(let p=0;p<=_h;p++)e.push(void 0);const n=new Map;for(const p of t.chars)p.id<=_h?e[p.id]=p:n.set(p.id,p);const r=8722;n.has(r)||n.set(r,e[45]);function o(p){return(p<=_h?e[p]:n.get(p))||e[63]}function i(p){return o(p.charCodeAt(0))}const s=t.common.base,a=i("x"),c=i("X"),l=i("q"),u=a.height-fa*2,f=c.height-fa*2,d=l.height-a.height+l.yoffset-a.yoffset;function h(p,b=1){let v=0;for(let y=0;y<p.length;y++)v+=o(p.charCodeAt(y)).xadvance;return v/s*b}return{measureWidth:h,getCharByCode:o,getChar:i,xHeight:u,capHeight:f,descent:d,common:t.common}}const Eb=2**31-1,hT=-2147483648;function dT(t,e,n,r=n){const o=new Array(t);o.fill(Eb);let i=hT,s=-1/0,a=!1;const c=new Array(t);c.fill(0);const l=e[0],f=(e[1]-e[0])/t,d=(y,A)=>{const S=(y-l)/f,E=Math.floor(S);return lo(A&&E==S?E-1:E,0,t-1)};function h(y,A,S){if(a)return;if(A>i)i=A;else{a=!0,console.debug("Items are not ordered properly. Disabling binned index.");return}const E=n(y);if(E<s){a=!0,console.debug("Items are not ordered properly. Disabling binned index.");return}s=E;const I=d(E,!1);o[I]>A&&(o[I]=A),c[I]<S&&(c[I]=S)}function p(y,A,S){if(a)return;if(A>i)i=A;else{a=!0,console.debug("Items (vertices) are not ordered properly. Disabling binned index.");return}const E=n(y),I=r(y);if(E<s){a=!0,console.debug("Items are not ordered properly. Disabling binned index.");return}else if(I<E){a=!0,console.debug("End index is less than start index. Disabling binned index. Datum: ",y);return}s=E;const _=d(E,!1),B=d(I,!0);for(let N=_;N<=B;N++)o[N]>A&&(o[N]=A),c[N]<S&&(c[N]=S)}const b=(y,A,S=[0,0])=>{const E=d(y,!1),I=d(A,!0),_=o[E],B=Math.max(c[I],_);return S[0]=_,S[1]=B,S},v=()=>{if(a)return;for(let A=1;A<c.length;A++)c[A]<c[A-1]&&(c[A]=c[A-1]);let y=!0;for(let A=o.length-1;A>0;A--)y&&o[A]==Eb?(o[A]=c[A],y=!1):o[A-1]>o[A]&&(o[A-1]=o[A]);return b};return h.getIndex=v,p.getIndex=v,n==r?h:p}function pT(){let t=0,e,n=0;const r=new Map,o=i=>(i===e||(n=r.get(i),n===void 0&&(n=t++,r.set(i,n)),e=i),n);return o.addAll=i=>{for(const s of i)o(s)},o.invert=i=>{for(const s of r.entries())if(s[1]==i)return s[0]},o.domain=()=>[...r.keys()],o}class ha{constructor({encoders:e,numVertices:n=void 0,attributes:r=[]}){this.encoders=e,this.variableEncoders=Object.fromEntries(Object.entries(e).filter(([i,s])=>r.includes(i)&&s&&!s.constant));const o=[...xb(e).entries()].filter(([i,s])=>i[1]&&s.length>1).map(([i,s])=>s);this.allocatedVertices=n,this.variableBuilder=new fT(n);for(const[i,s]of Object.entries(this.variableEncoders)){const a=s.dataAccessor;if(!a)continue;const c=o.find(S=>S.find(E=>E==i));if(c&&i!=c[0])continue;const l=a.asNumberAccessor(),u=s.scale,{largeHp:f,arrayConstructor:d,discrete:h,numComponents:p}=ho(u,i),b=[0,0];let v;u&&h&&"domain"in u&&(v=pT(),v.addAll(u.domain()));const y=v?S=>v(a(S)):f?S=>wb(l(S),b):l,A=c?kh(c):i;this.variableBuilder.addConverter(A,{f:y,numComponents:p,arrayReference:f?b:void 0,targetArrayType:d})}this.lastOffset=0,this.rangeMap=new jn([],JSON.stringify)}registerBatch(e){var i;const n=this.lastOffset,r=this.variableBuilder.vertexCount,o=r-n;o&&this.rangeMap.set(e,{offset:n,count:o,xIndex:(i=this.xIndexer)==null?void 0:i.getIndex()}),this.lastOffset=r}addBatches(e){for(const[n,r]of e)this.addBatch(n,r)}addBatch(e,n,r=0,o=n.length){this.prepareXIndexer(n,r,o);for(let i=r;i<o;i++){const s=n[i];this.variableBuilder.pushFromDatum(s),this.addToXIndex(s)}this.registerBatch(e)}prepareXIndexer(e,n=0,r=n+e.length){var l;const o=()=>{this.addToXIndex=u=>{},this.xIndexer=void 0},i=(l=this.encoders.x)==null?void 0:l.channelDef;if(!("buildIndex"in i)||!i.buildIndex||!e.length||r-n<0){o();return}const s=u=>{var f;return u&&kt((f=u.scale)==null?void 0:f.type)&&u},a=s(this.variableEncoders.x),c=s(this.variableEncoders.x2);if(a&&!a.constant&&(!c||!c.constant)){const u=a.dataAccessor.asNumberAccessor(),f=c?c.dataAccessor.asNumberAccessor():u,d=[u(e[n]),f(e[r-1])];if(d[1]>d[0]){this.xIndexer=dT(50,d,u,f);let h=this.variableBuilder.vertexCount;this.addToXIndex=p=>{let b=this.variableBuilder.vertexCount;this.xIndexer(p,h,b),h=b}}else o()}else o()}addToXIndex(e){}toArrays(){return{arrays:this.variableBuilder.arrays,vertexCount:this.variableBuilder.vertexCount,allocatedVertices:this.allocatedVertices,rangeMap:this.rangeMap}}}class gT extends ha{constructor({encoders:e,attributes:n,numItems:r}){super({encoders:e,attributes:n,numVertices:r*6}),this.variableBuilder.configure();const o=this.variableBuilder.pushAll;this.pushAllSixTimes=r>500?new Function("pushAll",`return function unrolledPushAllSixTimes() {
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};`)(o):function(){o(),o(),o(),o(),o(),o()}}addBatch(e,n,r=0,o=n.length){if(!(o<=r)){this.prepareXIndexer(n,r,o);for(let i=r;i<o;i++){const s=n[i];this.variableBuilder.updateFromDatum(s),this.pushAllSixTimes(),this.addToXIndex(s)}this.registerBatch(e)}}}class mT extends ha{constructor({encoders:e,attributes:n,tessellationThreshold:r=1/0,visibleRange:o=[-1/0,1/0],numItems:i}){super({encoders:e,attributes:n,numVertices:r==1/0?i*6:void 0}),this.visibleRange=o,this.tessellationThreshold=r||1/0,this.updateSide=this.variableBuilder.createUpdater("side",1),this.updatePos=this.variableBuilder.createUpdater("pos",1),this.variableBuilder.configure()}addBatch(e,n,r=0,o=n.length){this.prepareXIndexer(n,r,o);for(let i=r;i<o;i++){const s=n[i];this.variableBuilder.updateFromDatum(s),this.updateSide(-.5),this.updatePos(0),this.variableBuilder.pushAll();const a=1;for(let c=0;c<=a;c++)this.updatePos(c/a),this.updateSide(-.5),this.variableBuilder.pushAll(),this.updateSide(.5),this.variableBuilder.pushAll();this.variableBuilder.pushAll(),this.addToXIndex(s)}this.registerBatch(e)}}class bT extends ha{constructor({encoders:e,attributes:n,numItems:r=void 0}){super({encoders:e,attributes:n,numVertices:r}),this.variableBuilder.configure()}}class yT extends ha{constructor({encoders:e,attributes:n,numItems:r=void 0}){super({encoders:e,attributes:n,numVertices:r}),this.variableBuilder.configure()}toArrays(){const e=this.variableBuilder.arrays;for(let n of Object.values(e))n.divisor=1;return super.toArrays()}}class wT extends ha{constructor({encoders:e,attributes:n,fontMetrics:r,properties:o,numCharacters:i=void 0}){super({encoders:e,attributes:n,numVertices:i*6}),this.metadata=r,this.metrics=r,this.properties=o;const a=e.text.channelDef;this.numberFormat=!fn(a)&&"format"in a&&a.format?Bt(a.format):c=>c,this.updateVertexCoord=this.variableBuilder.createUpdater("vertexCoord",2),this.updateTextureCoord=this.variableBuilder.createUpdater("textureCoord",2),this.updateWidth=this.variableBuilder.createUpdater("width",1),this.variableBuilder.configure()}addBatch(e,n,r=0,o=n.length){const i=this.properties.align||"left",s=this.properties.logoLetters??!1,a=this.metadata.common.base,c=this.metadata.common.scaleH;let l=-5;switch(this.properties.baseline){case"top":l+=this.metrics.capHeight;break;case"middle":l+=this.metrics.capHeight/2;break;case"bottom":l-=this.metrics.descent;break}const u=this.encoders.text,f=[0,0];this.updateVertexCoord(f);const d=[0,0];this.updateTextureCoord(d),this.prepareXIndexer(n,r,o);for(let h=r;h<o;h++){const p=n[h],b=this.numberFormat(u(p)),v=nt(b)?b:b===null?"":""+b;if(v.length==0)continue;this.variableBuilder.updateFromDatum(p);const y=s?v.length:this.metrics.measureWidth(v);this.updateWidth(y);let A=i=="right"?-y:i=="center"?-y/2:0;if(!s){const _=this.metrics.getCharByCode(v.charCodeAt(0));A-=(_.width-_.xadvance)/a/2}let S=-.5,E=1,I=1;for(let _=0;_<v.length;_++){const B=this.metrics.getCharByCode(v.charCodeAt(_)),N=s?1:B.xadvance/a;if(B.id==32){A+=N;continue}s?(I=(B.width+fa*2)/B.width,A=-I/2,E=(B.height+fa*2)/B.height,S=-.5-fa/B.height):(E=B.height/a,S=-(B.height+B.yoffset+l)/a,I=B.width/a);const
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};`)(o):function(){o(),o(),o(),o(),o(),o()}}addBatch(e,n,r=0,o=n.length){if(!(o<=r)){this.prepareXIndexer(n,r,o);for(let i=r;i<o;i++){const s=n[i];this.variableBuilder.updateFromDatum(s),this.pushAllSixTimes(),this.addToXIndex(s)}this.registerBatch(e)}}}class mT extends ha{constructor({encoders:e,attributes:n,tessellationThreshold:r=1/0,visibleRange:o=[-1/0,1/0],numItems:i}){super({encoders:e,attributes:n,numVertices:r==1/0?i*6:void 0}),this.visibleRange=o,this.tessellationThreshold=r||1/0,this.updateSide=this.variableBuilder.createUpdater("side",1),this.updatePos=this.variableBuilder.createUpdater("pos",1),this.variableBuilder.configure()}addBatch(e,n,r=0,o=n.length){this.prepareXIndexer(n,r,o);for(let i=r;i<o;i++){const s=n[i];this.variableBuilder.updateFromDatum(s),this.updateSide(-.5),this.updatePos(0),this.variableBuilder.pushAll();const a=1;for(let c=0;c<=a;c++)this.updatePos(c/a),this.updateSide(-.5),this.variableBuilder.pushAll(),this.updateSide(.5),this.variableBuilder.pushAll();this.variableBuilder.pushAll(),this.addToXIndex(s)}this.registerBatch(e)}}class bT extends ha{constructor({encoders:e,attributes:n,numItems:r=void 0}){super({encoders:e,attributes:n,numVertices:r}),this.variableBuilder.configure()}}class yT extends ha{constructor({encoders:e,attributes:n,numItems:r=void 0}){super({encoders:e,attributes:n,numVertices:r}),this.variableBuilder.configure()}toArrays(){const e=this.variableBuilder.arrays;for(let n of Object.values(e))n.divisor=1;return super.toArrays()}}class wT extends ha{constructor({encoders:e,attributes:n,fontMetrics:r,properties:o,numCharacters:i=void 0}){super({encoders:e,attributes:n,numVertices:i*6}),this.metadata=r,this.metrics=r,this.properties=o;const a=e.text.channelDef;this.numberFormat=!fn(a)&&"format"in a&&a.format?Bt(a.format):c=>c,this.updateVertexCoord=this.variableBuilder.createUpdater("vertexCoord",2),this.updateTextureCoord=this.variableBuilder.createUpdater("textureCoord",2),this.updateWidth=this.variableBuilder.createUpdater("width",1),this.variableBuilder.configure()}addBatch(e,n,r=0,o=n.length){const i=this.properties.align||"left",s=this.properties.logoLetters??!1,a=this.metadata.common.base,c=this.metadata.common.scaleH;let l=-5;switch(this.properties.baseline){case"top":l+=this.metrics.capHeight;break;case"middle":l+=this.metrics.capHeight/2;break;case"bottom":l-=this.metrics.descent;break}const u=this.encoders.text,f=[0,0];this.updateVertexCoord(f);const d=[0,0];this.updateTextureCoord(d),this.prepareXIndexer(n,r,o);for(let h=r;h<o;h++){const p=n[h],b=this.numberFormat(u(p)),v=nt(b)?b:b===null?"":""+b;if(v.length==0)continue;this.variableBuilder.updateFromDatum(p);const y=s?v.length:this.metrics.measureWidth(v);this.updateWidth(y);let A=i=="right"?-y:i=="center"?-y/2:0;if(!s){const _=this.metrics.getCharByCode(v.charCodeAt(0));A-=(_.width-_.xadvance)/a/2}let S=-.5,E=1,I=1;for(let _=0;_<v.length;_++){const B=this.metrics.getCharByCode(v.charCodeAt(_)),N=s?1:B.xadvance/a;if(B.id==32){A+=N;continue}s?(I=(B.width+fa*2)/B.width,A=-I/2,E=(B.height+fa*2)/B.height,S=-.5-fa/B.height):(E=B.height/a,S=-(B.height+B.yoffset+l)/a,I=B.width/a);const F=B.x,M=B.y;f[0]=A,f[1]=S+E,d[0]=F/c,d[1]=M/c,this.variableBuilder.pushAll(),f[0]=A+I,f[1]=S+E,d[0]=(F+B.width)/c,d[1]=M/c,this.variableBuilder.pushAll(),f[0]=A,f[1]=S,d[0]=F/c,d[1]=(M+B.height)/c,this.variableBuilder.pushAll(),f[0]=A+I,f[1]=S+E,d[0]=(F+B.width)/c,d[1]=M/c,this.variableBuilder.pushAll(),f[0]=A,f[1]=S,d[0]=F/c,d[1]=(M+B.height)/c,this.variableBuilder.pushAll(),f[0]=A+I,f[1]=S,d[0]=(F+B.width)/c,d[1]=(M+B.height)/c,this.variableBuilder.pushAll(),A+=N}this.addToXIndex(p)}this.registerBatch(e)}}const Sb=`#define PI 3.141593
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uniform View{mediump vec2 uViewOffset;mediump vec2 uViewScale;mediump vec2 uViewportSize;lowp float uDevicePixelRatio;lowp float uViewOpacity;bool uPickingEnabled;};/***Maps a coordinate on the unit scale to a normalized device coordinate.*(0,0)is at the bottom left corner.*/vec4 unitToNdc(vec2 coord){return vec4((coord*uViewScale+uViewOffset)*2.0-1.0,0.0,1.0);}vec4 unitToNdc(float x,float y){return unitToNdc(vec2(x,y));}vec4 pixelsToNdc(vec2 coord){return unitToNdc(coord/uViewportSize);}vec4 pixelsToNdc(float x,float y){return pixelsToNdc(vec2(x,y));}float linearstep(float edge0,float edge1,float x){return clamp((x-edge0)/(edge1-edge0),0.0,1.0);}bool isEmptyBinarySearchTexture(highp usampler2D s){return textureSize(s,0).x==1&&texelFetch(s,ivec2(0,0),0).r==0u;}bool binarySearchTexture(highp usampler2D s,uint value){int texSize=textureSize(s,0).x;int left=0;int right=texSize-1;while(left<=right){int mid=left+(right-left)/2;uint midValue=texelFetch(s,ivec2(mid,0),0).r;if(midValue==value){return true;}if(midValue<value){left=mid+1;}else{right=mid-1;}}return false;}/***Calculates a gamma for antialiasing opacity based on the color.*/float getGammaForColor(vec3 rgb){return mix(1.25,0.75,smoothstep(0.0,1.0,dot(rgb,vec3(0.299,0.587,0.114))));}/***Specialized linearstep for doing antialiasing*/float distanceToRatio(float d){return clamp(d*uDevicePixelRatio+0.5,0.0,1.0);}vec4 distanceToColor(float d,vec4 fill,vec4 stroke,vec4 background,float halfStrokeWidth){if(halfStrokeWidth>0.0){float sd=abs(d)-halfStrokeWidth;return mix(stroke,d<=0.0 ? fill : background,distanceToRatio(sd));}else{return mix(background,fill,distanceToRatio(-d));}}`,xT="uniform highp float uZero;vec3 getDiscreteColor(sampler2D s,int index){return texelFetch(s,ivec2(index % textureSize(s,0).x,0),0).rgb;}vec3 getInterpolatedColor(sampler2D s,float unitValue){return texture(s,vec2(unitValue,0.0)).rgb;}float clampToRange(float value,vec2 range){return clamp(value,min(range[0],range[1]),max(range[0],range[1]));}float scaleIdentity(float value){return value;}float scaleIdentity(uint value){return float(value);}float scaleLinear(float value,vec2 domain,vec2 range){float domainSpan=domain[1]-domain[0];float rangeSpan=range[1]-range[0];return(value-domain[0])/domainSpan*rangeSpan+range[0];}float scaleLog(float value,vec2 domain,vec2 range,float base){return scaleLinear(log(value)/log(base),log(domain)/log(base),range);}float symlog(float value,float constant){return sign(value)*log(abs(value/constant)+1.0);}float scaleSymlog(float value,vec2 domain,vec2 range,float constant){return scaleLinear(symlog(value,constant),vec2(symlog(domain[0],constant),symlog(domain[1],constant)),range);}float scalePow(float value,vec2 domain,vec2 range,float exponent){return scaleLinear(pow(abs(value),exponent)*sign(value),pow(abs(domain),vec2(exponent))*sign(domain),range);}float scaleBand(uint value,vec2 domainExtent,vec2 range,float paddingInner,float paddingOuter,float align,float band){float start=range[0];float stop=range[1];float rangeSpan=stop-start;float n=domainExtent[1]-domainExtent[0];paddingInner=int(n)>1 ? paddingInner : 0.0;float step=rangeSpan/max(1.0,n-paddingInner+paddingOuter*2.0);start+=(rangeSpan-step*(n-paddingInner))*align;float bandwidth=step*(1.0-paddingInner);return start+(float(value)-domainExtent[0])*step+bandwidth*band;}const int lowBits=12;const float lowDivisor=pow(2.0,float(lowBits));const uint lowMask=uint(lowDivisor-1.0);vec2 splitUint(uint value){uint valueLo=value&lowMask;uint valueHi=value-valueLo;return vec2(float(valueHi),float(valueLo));}/***High precision variant of scaleBand for index/locus scales*/float scaleBandHp(uint value,vec3 domainExtent,vec2 range,float paddingInner,float paddingOuter,float align,float band){float start=range[0];float stop=range[1];float rangeSpan=stop-start;vec2 domainStart=domainExtent.xy;float n=domainExtent[2];float step=rangeSpan/max(1.0,n-paddingInner+paddingOuter*2.0);start+=(rangeSpan-step*(n-paddingInner))*align;float bandwidth=step*(1.0-paddingInner);vec2 splitValue=splitUint(value);float inf=1.0/uZero;float hi=max(splitValue[0]-domainStart[0],-inf);float lo=max(splitValue[1]-domainStart[1],-inf);return dot(vec4(start,hi,lo,bandwidth),vec4(1.0,step,step,band));}/***High precision variant of scaleBand for index/locus scales for large*domains where 32bit uints are not sufficient to represent the domain.*/float scaleBandHp(uvec2 value,vec3 domainExtent,vec2 range,float paddingInner,float paddingOuter,float align,float band){float start=range[0];float stop=range[1];float rangeSpan=stop-start;vec2 domainStart=domainExtent.xy;float n=domainExtent[2];float step=rangeSpan/max(1.0,n-paddingInner+paddingOuter*2.0);start+=(rangeSpan-step*(n-paddingInner))*align;float bandwidth=step*(1.0-paddingInner);vec2 splitValue=vec2(float(value[0])*lowDivisor,float(value[1]));float inf=1.0/uZero;float hi=max(splitValue[0]-domainStart[0],-inf);float lo=max(splitValue[1]-domainStart[1],-inf);return dot(vec4(start,hi,lo,bandwidth),vec4(1.0,step,step,band));}",vT=`/***Describes where a sample facet should be shown. Interpolating between the*current and target positions/heights allows for transitioning between facet*configurations.*/struct SampleFacetPosition{float pos;float height;float targetPos;float targetHeight;};/***Trasition fraction[0,1]between the current and target configurations.*/uniform float uTransitionOffset;
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SampleFacetPosition getSampleFacetPos(){return SampleFacetPosition(0.0,1.0,0.0,1.0);}
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@@ -359,14 +359,14 @@ uint id=attr_uniqueId;vPickingColor=vec4(ivec4(id>>0,id>>8,id>>16,id>>24)&0xFF)/
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-
return true;}return false;}`,ET="in highp vec4 vPickingColor;",El=Symbol("cacheMap");function Sl(t,e,n){let r=da(t).get(e);return r===void 0&&(r=n(e),da(t).set(e,r)),r}function ST(t,e){da(t).delete(e)}function Cl(t,e){const n=da(t);for(const r of n.keys())r.startsWith(e)&&n.delete(r);da(t).delete(e)}function Cb(t){t[El]=new Map}function da(t){return t[El]||Cb(t),t[El]}function Ib(...t){const e={get(n,r,o){for(const i of t){const a=i()[r];if(a!==void 0)return a}},has(n,r,o){for(const i of t){const s=i();if(r in s)return!0}return!1}};return new Proxy({},e)}function CT(t){return nt(t)||Gt(t)||is(t)}class Fr extends Error{constructor(e,n){super(e),this.name="ViewError",this.view=n}}const IT="SAMPLE_FACET_UNIFORM",Tb="SAMPLE_FACET_TEXTURE",Db="uSelectionTexture_";class pa{constructor(e){ge(this,Tn,[]);this.unitView=e,this.encoders=void 0,this.bufferInfo=void 0,this.bytesPerElement=new Map,this.programInfo=void 0,this.vertexArrayInfo=void 0,this.viewUniformInfo=void 0,this.markUniformInfo=void 0,this.markUniformsAltered=!0,this.selectionTextureOps=[],this.rangeMap=new TT,this.defaultProperties={get clip(){return["x","y"].map(n=>e.getScaleResolution(n)).some(n=>(n==null?void 0:n.isZoomable())??!1)},xOffset:0,yOffset:0,minBufferSize:0},this.properties=Ib(typeof this.unitView.spec.mark=="object"?()=>this.unitView.spec.mark:()=>({}),()=>this.defaultProperties)}augmentDefaultProperties(e){Object.defineProperties(this.defaultProperties,Object.getOwnPropertyDescriptors(e))}get opaque(){return!1}get defaultHitTestMode(){return"intersects"}getAttributes(){throw new Error("Not implemented!")}getSupportedChannels(){return["sample","facetIndex","x","y","color","opacity","search","uniqueId"]}getDefaultEncoding(){const e={sample:void 0,uniqueId:void 0};return this.isPickingParticipant()&&(e.uniqueId={field:ln}),e}fixEncoding(e){return e}setupExprRefsNeedingGraphicsUpdate(e){const n=this.getSupportedChannels(),r={};for(const i of e){const s=this.properties[i];if(s&&qt(s)){const a=this.unitView.paramMediator.createExpression(s.expr);a.addListener(()=>{this.updateGraphicsData(),this.unitView.context.animator.requestRender()}),n.includes(i)||Object.defineProperty(r,i,{get(){return a()}})}}const o=this.properties;this.properties=Ib(()=>r,()=>o)}get encoding(){return Sl(this,"encoding",()=>{var s;const e=this.getDefaultEncoding(),n=this.unitView.getEncoding(),r=a=>{const c=this.properties[a];return CT(c)||qt(c)?{value:c}:void 0},o=Object.fromEntries(this.getSupportedChannels().map(a=>[a,r(a)]).filter(a=>fn(a[1]))),i=this.fixEncoding({...e,...o,...n});for(const a of Object.keys(i))this.getSupportedChannels().includes(a)||delete i[a];return i.x&&((s=i.x).buildIndex??(s.buildIndex=!0)),i})}getContext(){return this.unitView.context}getType(){return this.unitView.getMarkType()}initializeData(){}initializeEncoders(){this.encoders=FI(this.unitView,this.encoding)}async initializeGraphics(){}updateGraphicsData(){}getSampleFacetMode(){if(this.encoders.facetIndex)return Tb;if(this.unitView.getLayoutAncestors().find(e=>"samples"in e.spec))return IT}createAndLinkShaders(e,n,r=[]){const o=this.getAttributes(),i=this.encoders,s=this.getSampleFacetMode();s&&r.push(`#define ${s}`);const a="// view: "+this.unitView.getPathString();let c=[];const l=new Set,u=xb(i),f=[],d=Object.values(i).flatMap(I=>I.accessors).map(I=>I.predicate).filter(I=>I.param),h=new Map;for(const I of d){const _=I.param,B=this.unitView.paramMediator,N=B.findValue(_);if(!N)throw new Error(`Cannot infer selection type as the parameter "${_}" has no value. Please ensure that the parameter is properly defined!`);const
|
|
363
|
-
return ${Al}${_} == ${
|
|
364
|
-
}`)}}else if(Ah(N)){if(!h.has(_)){h.set(_,"multi");const
|
|
365
|
-
uniform highp usampler2D ${
|
|
366
|
-
return binarySearchTexture(${Q}, ${
|
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367
|
-
}`),C.createSelectionTexture(N);const se=B.createExpression(_);se.addListener(()=>{const oe=se(null);C.createSelectionTexture(oe),this.getContext().animator.requestRender()})}}else if(X1(N)&&!h.has(_)){h.set(_,"interval");const
|
|
368
|
-
return ${
|
|
369
|
-
}`)}}const p=(I,_,B,N)=>{const
|
|
362
|
+
return true;}return false;}`,ET="in highp vec4 vPickingColor;",El=Symbol("cacheMap");function Sl(t,e,n){let r=da(t).get(e);return r===void 0&&(r=n(e),da(t).set(e,r)),r}function ST(t,e){da(t).delete(e)}function Cl(t,e){const n=da(t);for(const r of n.keys())r.startsWith(e)&&n.delete(r);da(t).delete(e)}function Cb(t){t[El]=new Map}function da(t){return t[El]||Cb(t),t[El]}function Ib(...t){const e={get(n,r,o){for(const i of t){const a=i()[r];if(a!==void 0)return a}},has(n,r,o){for(const i of t){const s=i();if(r in s)return!0}return!1}};return new Proxy({},e)}function CT(t){return nt(t)||Gt(t)||is(t)}class Fr extends Error{constructor(e,n){super(e),this.name="ViewError",this.view=n}}const IT="SAMPLE_FACET_UNIFORM",Tb="SAMPLE_FACET_TEXTURE",Db="uSelectionTexture_";class pa{constructor(e){ge(this,Tn,[]);this.unitView=e,this.encoders=void 0,this.bufferInfo=void 0,this.bytesPerElement=new Map,this.programInfo=void 0,this.vertexArrayInfo=void 0,this.viewUniformInfo=void 0,this.markUniformInfo=void 0,this.markUniformsAltered=!0,this.selectionTextureOps=[],this.rangeMap=new TT,this.defaultProperties={get clip(){return["x","y"].map(n=>e.getScaleResolution(n)).some(n=>(n==null?void 0:n.isZoomable())??!1)},xOffset:0,yOffset:0,minBufferSize:0},this.properties=Ib(typeof this.unitView.spec.mark=="object"?()=>this.unitView.spec.mark:()=>({}),()=>this.defaultProperties)}augmentDefaultProperties(e){Object.defineProperties(this.defaultProperties,Object.getOwnPropertyDescriptors(e))}get opaque(){return!1}get defaultHitTestMode(){return"intersects"}getAttributes(){throw new Error("Not implemented!")}getSupportedChannels(){return["sample","facetIndex","x","y","color","opacity","search","uniqueId"]}getDefaultEncoding(){const e={sample:void 0,uniqueId:void 0};return this.isPickingParticipant()&&(e.uniqueId={field:ln}),e}fixEncoding(e){return e}setupExprRefsNeedingGraphicsUpdate(e){const n=this.getSupportedChannels(),r={};for(const i of e){const s=this.properties[i];if(s&&qt(s)){const a=this.unitView.paramMediator.createExpression(s.expr);a.addListener(()=>{this.updateGraphicsData(),this.unitView.context.animator.requestRender()}),n.includes(i)||Object.defineProperty(r,i,{get(){return a()}})}}const o=this.properties;this.properties=Ib(()=>r,()=>o)}get encoding(){return Sl(this,"encoding",()=>{var s;const e=this.getDefaultEncoding(),n=this.unitView.getEncoding(),r=a=>{const c=this.properties[a];return CT(c)||qt(c)?{value:c}:void 0},o=Object.fromEntries(this.getSupportedChannels().map(a=>[a,r(a)]).filter(a=>fn(a[1]))),i=this.fixEncoding({...e,...o,...n});for(const a of Object.keys(i))this.getSupportedChannels().includes(a)||delete i[a];return i.x&&((s=i.x).buildIndex??(s.buildIndex=!0)),i})}getContext(){return this.unitView.context}getType(){return this.unitView.getMarkType()}initializeData(){}initializeEncoders(){this.encoders=FI(this.unitView,this.encoding)}async initializeGraphics(){}updateGraphicsData(){}getSampleFacetMode(){if(this.encoders.facetIndex)return Tb;if(this.unitView.getLayoutAncestors().find(e=>"samples"in e.spec))return IT}createAndLinkShaders(e,n,r=[]){const o=this.getAttributes(),i=this.encoders,s=this.getSampleFacetMode();s&&r.push(`#define ${s}`);const a="// view: "+this.unitView.getPathString();let c=[];const l=new Set,u=xb(i),f=[],d=Object.values(i).flatMap(I=>I.accessors).map(I=>I.predicate).filter(I=>I.param),h=new Map;for(const I of d){const _=I.param,B=this.unitView.paramMediator,N=B.findValue(_);if(!N)throw new Error(`Cannot infer selection type as the parameter "${_}" has no value. Please ensure that the parameter is properly defined!`);const F=fo+"uniqueId";if(K1(N)){if(!h.has(_)){h.set(_,"single");const M=Al+ra(_);f.push(" // Selection parameter"),f.push(` uniform highp uint ${M};`),W(this,Tn).push(()=>{this.registerMarkUniformValue(M,{expr:_},C=>C.uniqueId??0)}),c.push(`bool ${la}${_}(bool empty) {
|
|
363
|
+
return ${Al}${_} == ${F} || (empty && ${Al}${_} == 0u);
|
|
364
|
+
}`)}}else if(Ah(N)){if(!h.has(_)){h.set(_,"multi");const M=Db+ra(_);c.push(`// Selection texture
|
|
365
|
+
uniform highp usampler2D ${M};`);const C=this.getContext().glHelper,Y=C.selectionTextures;this.selectionTextureOps.push(()=>{const oe=B.getValue(_),ae=Y.get(oe);if(!ae)throw new Error(`Bug: no selection texture found for "${_}"!`);oi(this.programInfo,{[M]:ae})});const Q=Db+_;c.push(`bool ${la}${_}(bool empty) {
|
|
366
|
+
return binarySearchTexture(${Q}, ${F}) || (empty && isEmptyBinarySearchTexture(${Q}));
|
|
367
|
+
}`),C.createSelectionTexture(N);const se=B.createExpression(_);se.addListener(()=>{const oe=se(null);C.createSelectionTexture(oe),this.getContext().animator.requestRender()})}}else if(X1(N)&&!h.has(_)){h.set(_,"interval");const M=[],C=[];for(const Y of Object.keys(N.intervals)){if(!["x","y"].includes(Y))continue;const Q=Al+ra(_)+`_${Y}`,{attributeType:se}=ho(this.unitView.getScaleResolution(Y).scale,Y);f.push(" // Selection parameter"),f.push(` uniform highp ${se}[2] ${Q};`),W(this,Tn).push(()=>{this.registerMarkUniformValue(Q,{expr:_},he=>he.intervals[Y]??[1/0,-1/0])});const oe=fo+Y,ae=Q+"[0]",ce=Q+"[1]",ye=cb(Y);if(this.encoding[ye]){const he=fo+ye,De=this.defaultHitTestMode;if(De=="endpoints")M.push(`((${ae} <= ${oe} && ${oe} <= ${ce}) || (${ae} <= ${he} && ${he} <= ${ce}))`);else if(De=="encloses")M.push(`(${ae} <= ${oe} && ${he} <= ${ce})`);else if(De=="intersects")M.push(`(${ae} <= ${he} && ${oe} <= ${ce})`);else throw new Fr(`Unsupported hit test mode "${De}" for interval selection!`,this.unitView)}else M.push(`(${ae} <= ${oe} && ${oe} <= ${ce})`);C.push(`${ae} > ${ce}`)}c.push(`bool ${la}${_}(bool empty) {
|
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368
|
+
return ${M.join(" && ")} || (empty && (${C.join(" || ")}));
|
|
369
|
+
}`)}}const p=(I,_,B,N)=>{const F=_.channelDef;if(fn(F))if(qt(F.value)){const{uniformName:M,uniformGlsl:C,accessorGlsl:Y,adjuster:Q}=eT(I,B);c.push(Y),f.push(C),W(this,Tn).push(()=>{this.registerMarkUniformValue(M,F.value,Q)})}else c.push($I(I,B,F.value).accessorGlsl);else if(ia(F)){const{uniformName:M,uniformGlsl:C,accessorGlsl:Y}=tT(I,N,B);f.push(C),c.push(Y);const{largeHp:Q,discrete:se}=ho(N,I),oe=se&&"domain"in N?ae=>N.domain().indexOf(ae):Q?wb:ae=>+ae;W(this,Tn).push(()=>{this.registerMarkUniformValue(M,F.datum,oe)})}else if(_r(F)){const M=u.get([F.field,!0]),{attributeGlsl:C,accessorGlsl:Y}=db(I,N,B,M!=null&&M.includes(I)?M:void 0);l.add(C),c.push(Y)}else if(oa(F)){const{attributeGlsl:M,accessorGlsl:C}=db(I,N,B);l.add(M),c.push(C)}else throw new Fr(`Unsupported channel definition: ${JSON.stringify(F)}`,this.unitView)};for(const[I,_]of Object.entries(i)){if(!o.includes(I))continue;const{channelDef:B,accessors:N,scale:F}=_;for(let M=0;M<N.length;M++)p(I,N[M],M,F);if(F){const M=en(B)&&B.resolutionChannel||I,C=aa(M)?this.unitView.getScaleResolution(M):null,{glsl:Y,domainUniform:Q,domainUniformName:se,rangeUniform:oe,rangeUniformName:ae}=nT(I,F,B);c.push(Y),f.push(Q),f.push(oe),oe&&W(this,Tn).push(()=>{const ce=this.createMarkUniformSetter(ae),ye=()=>ce(vb(F,I));C.addEventListener("range",ye),ye()}),Q&&W(this,Tn).push(()=>{const ce=this.createMarkUniformSetter(se),ye=()=>{const he=Dr(F.type)?[0,F.domain().length]:F.domain();ce(yb(F.type)?cT(he):he)};C.addEventListener("domain",ye),ye()})}c.push(rT(I,N))}const b=[...h.keys()].map(I=>`${la}${I}(false)`);c.push(`bool isPointSelected() {
|
|
370
370
|
`+(this.encoders.uniqueId&&b.length>0?` return ${b.join(" || ")};`:" return false;")+`
|
|
371
371
|
}`);const v=`precision highp float;
|
|
372
372
|
precision highp int;`,y=I=>I.replace("#pragma markUniforms",f.join(`
|
|
@@ -582,7 +582,7 @@ chrM 16299`};function SD(t){if(!(t in Gb))throw new Error(`Unknown assembly: ${t
|
|
|
582
582
|
<div class="title">
|
|
583
583
|
<strong>${a}</strong>
|
|
584
584
|
</div>
|
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585
|
-
`:"";return ot`${c}${s}`}class xa extends ry{constructor(e,n,r,o,i,s){super(e,n,r,o,i,s),this.spec=e}async initializeChildren(){}*[Symbol.iterator](){}replaceChild(e,n){throw new Error("Not implemented")}visit(e){let n;try{n=e(this)}catch(r){throw r.view=this,r}if(n===ya)return n;if(n!==HD){e.beforeChildren&&e.beforeChildren(this);for(const r of this){const o=r.visit(e);if(o===ya)return o}e.afterChildren&&e.afterChildren(this),e.postOrder&&e.postOrder(this)}}findDescendantByPath(e){for(const n of this)if(n.name===e[0]){if(e.length==1)return n;if(n instanceof xa)return n.findDescendantByPath(e.slice(1))}}findChildByName(e){for(const n of this)if(n.name===e)return n}findDescendantByName(e){let n;return this.visit(r=>{if(r.name==e)return n=r,ya}),n}getDefaultResolution(e,n){return"shared"}}class mo extends xa{constructor(n,r,o,i,s,a){super(n,r,o,i,s,{layersChildren:!0,...a});ge(this,sr,[]);this.spec=n,this.needsAxes={x:!0,y:!0}}async initializeChildren(){Te(this,sr,await Promise.all(this.spec.layer.map((n,r)=>this.context.createOrImportView(n,this,this,"grid"+r,o=>{if(!Jh(o)&&!Kh(o))throw new Fr("LayerView accepts only unit or layer specs as children!",this)}))))}get children(){return W(this,sr).slice()}*[Symbol.iterator](){for(const n of W(this,sr))yield n}render(n,r,o={}){if(super.render(n,r,o),!!this.isConfiguredVisible()){n.pushView(this,r);for(const i of W(this,sr))i.render(n,r,o);n.popView(this)}}propagateInteractionEvent(n){this.handleInteractionEvent(void 0,n,!0);for(let r=W(this,sr).length-1;r>=0;r--)if(W(this,sr)[r].propagateInteractionEvent(n),n.stopped)return;this.handleInteractionEvent(void 0,n,!1)}}sr=new WeakMap;class Iy{constructor(e,n){this.n=e,this.maxCols=n??1/0}get nRows(){return this.maxCols==1/0?1:Math.ceil(this.n/this.maxCols)}get nCols(){return Math.min(this.n,this.maxCols)}get rowIndices(){const e=[],n=this.nCols,r=this.nRows;for(let o=0;o<r;o++){const i=[];e.push(i);for(let s=0;s<n;s++){const a=o*n+s;a<this.n&&i.push(a)}}return e}get colIndices(){const e=[],n=this.nCols,r=this.nRows;for(let o=0;o<n;o++){const i=[];e.push(i);for(let s=0;s<r;s++){const a=s*n+o;a<this.n&&i.push(a)}}return e}getCellIndex(e,n){let r=0;if(this.maxCols==1/0)r=n==0?e:void 0;else{if(e>=this.maxCols)return;r=n*this.nCols+e}return r<this.n?r:void 0}getCellCoords(e){if(!(e<0||e>=this.n))return[e%this.nCols,Math.floor(e/this.nCols)]}}const Rk="chromosome_ticks_and_labels",Fk={x:"width",y:"height"};function Yh(t){return t=="x"?"y":"x"}const _l={x:["bottom","top"],y:["left","right"]},Qh=Object.fromEntries(Object.entries(_l).map(([t,e])=>e.map(n=>[n,t])).flat(1));function Pr(t){return Qh[t]}class Ty extends mo{constructor(e,n,r,o,i,s){const a=n=="locus",c={...a?Pk:Dy,...Mk(n,e),...e};super(a?Lk(c,n):By(c,n),r,o,i,`axis_${e.orient}`,{blockEncodingInheritance:!0,contributesToScaleDomain:!1,...s}),this.axisProps=c}getSize(){const e={px:this.getPerpendicularSize()},n={grow:1};return Qh[this.axisProps.orient]=="x"?new Mr(n,e):new Mr(e,n)}getPerpendicularSize(){return Zh(this.axisProps)}isPickingSupported(){return!1}}function Zh(t){const e=Pr(t.orient);let n=t.ticks&&t.tickSize||0;return t.labels&&(n+=t.labelPadding,e=="x"?n+=t.labelFontSize:n+=30),t.title&&(n+=t.titlePadding+t.titleFontSize),n=Math.min(t.maxExtent||1/0,Math.max(t.minExtent||0,n)),n}const Dy={values:null,minExtent:20,maxExtent:1/0,offset:0,domain:!0,domainWidth:1,domainColor:"gray",domainDash:null,domainDashOffset:0,domainCap:"square",ticks:!0,tickSize:5,tickWidth:1,tickColor:"gray",tickDash:null,tickDashOffset:0,tickCap:"square",tickCount:null,tickMinStep:null,labels:!0,labelAlign:"center",labelBaseline:"middle",labelPadding:4,labelFontSize:10,labelLimit:180,labelColor:"black",format:null,titleColor:"black",titleFont:"sans-serif",titleFontSize:10,titlePadding:3};function Mk(t,e){const n=e.orient,r=t=="nominal"||t=="ordinal";let o="center",i="middle",s=e.labelAngle??((n=="top"||n=="bottom")&&r?-90:0);switch(n){case"left":o="right";break;case"right":o="left";break;case"top":case"bottom":Math.abs(s)>30?(o=s>0==(n=="bottom")?"left":"right",i="middle"):i=n=="top"?"alphabetic":"top";break}return{labelAlign:o,labelAngle:s,labelBaseline:i}}function By(t,e){const n={...t,extent:Zh(t)},r=Pr(n.orient),o=Yh(r),i=n.orient=="bottom"||n.orient=="right"?1:-1,s=n.orient=="bottom"||n.orient=="left"?1:0,a=()=>({name:"domain",data:{values:[{}]},mark:{type:"rule",clip:!1,strokeDash:n.domainDash,strokeCap:n.domainCap,color:n.domainColor,[o]:s,size:n.domainWidth}}),c=()=>({name:"labels",mark:{type:"text",clip:!1,align:n.labelAlign,angle:n.labelAngle,baseline:n.labelBaseline,[o+"Offset"]:(n.tickSize+n.labelPadding)*i,[o]:s,size:n.labelFontSize,color:n.labelColor,minBufferSize:1500},encoding:{[r]:{field:"value",type:e},text:{field:"label"}}}),l=()=>({name:"ticks",mark:{type:"rule",clip:!1,strokeDash:n.tickDash,strokeCap:n.tickCap,color:n.tickColor,size:n.tickWidth,minBufferSize:300},encoding:{[o]:{value:s},[o+"2"]:{value:s-n.tickSize/n.extent*(s?1:-1)}}}),u=()=>({name:"title",data:{values:[{}]},mark:{type:"text",clip:!1,align:"center",baseline:n.orient=="bottom"?"bottom":"top",angle:[0,90,0,-90][["top","right","bottom","left"].indexOf(n.orient)],text:n.title,color:n.titleColor,[r]:.5,[o]:1-s}}),f=()=>{const h={name:"ticks_and_labels",encoding:{[r]:{field:"value",type:e}},layer:[]};return n.ticks&&h.layer.push(l()),n.labels&&h.layer.push(c()),h},d={resolve:{scale:{[r]:"forced"}},[Fk[Yh(r)]]:n.extent,data:{lazy:{type:"axisTicks",channel:r,axis:t}},layer:[]};return n.domain&&d.layer.push(a()),(n.ticks||n.labels)&&d.layer.push(f()),n.title&&d.layer.push(u()),d}const Pk={...Dy,chromTicks:!0,chromTickSize:18,chromTickWidth:1,chromTickColor:"#989898",chromTickDash:[4,2],chromTickDashOffset:1,chromLabels:!0,chromLabelFontSize:13,chromLabelFontWeight:"normal",chromLabelFontStyle:"normal",chromLabelColor:"black",chromLabelAlign:"left",chromLabelPadding:7};function Lk(t,e){const n={...t,extent:Zh(t)},r=Pr(n.orient),o=Yh(r),i=n.orient=="bottom"||n.orient=="left"?1:0,s=()=>({name:"chromosome_ticks",mark:{type:"rule",strokeDash:t.chromTickDash,strokeDashOffset:t.chromTickDashOffset,[o]:i,[o+"2"]:i-n.chromTickSize/n.extent*(i?1:-1),color:t.chromTickColor,size:n.chromTickWidth}}),a=()=>{let u;switch(n.orient){case"top":u={y:0,angle:0,paddingX:4,dy:-n.chromLabelPadding,viewportEdgeFadeWidthLeft:20,viewportEdgeFadeWidthRight:20,viewportEdgeFadeDistanceRight:-10,viewportEdgeFadeDistanceLeft:-20};break;case"bottom":u={y:1,angle:0,paddingX:4,dy:n.chromLabelPadding+n.chromLabelFontSize*.73,viewportEdgeFadeWidthLeft:20,viewportEdgeFadeWidthRight:20,viewportEdgeFadeDistanceRight:-10,viewportEdgeFadeDistanceLeft:-20};break;case"left":u={x:1,angle:-90,paddingY:4,dy:-n.chromLabelPadding,viewportEdgeFadeWidthBottom:20,viewportEdgeFadeWidthTop:20,viewportEdgeFadeDistanceBottom:-20,viewportEdgeFadeDistanceTop:-10};break;case"right":u={x:0,angle:90,align:"right",paddingY:4,dy:-n.chromLabelPadding};break;default:u={}}return{name:"chromosome_labels",mark:{type:"text",size:n.chromLabelFontSize,font:n.chromLabelFont,fontWeight:n.chromLabelFontWeight,fontStyle:n.chromLabelFontStyle,color:n.chromLabelColor,align:t.chromLabelAlign,baseline:"alphabetic",clip:!1,...u},encoding:{[r+"2"]:{field:"continuousEnd",type:e},text:{field:"name"}}}};let c;switch(n.orient){case"bottom":case"top":c={};break;case"left":c={labelAngle:-90,labelAlign:"center",labelPadding:6};break;case"right":c={labelAngle:90,labelAlign:"center",labelPadding:6};break;default:c={}}const l=By({...t,...c},e);if(t.chromTicks||t.chromLabels){const u={name:Rk,data:{lazy:{type:"axisGenome",channel:Pr(n.orient)}},encoding:{[r]:{field:"continuousStart",type:e,band:0}},layer:[]};if(t.chromTicks&&u.layer.push(s()),t.chromLabels){u.layer.push(a());let f;l.layer.filter(d=>d.name=="ticks_and_labels").forEach(d=>d.layer.filter(h=>h.name=="labels").forEach(h=>{f=h.mark})),f&&(n.orient=="top"||n.orient=="bottom"?(f.viewportEdgeFadeWidthLeft=30,f.viewportEdgeFadeDistanceLeft=40):(f.viewportEdgeFadeWidthBottom=30,f.viewportEdgeFadeDistanceBottom=40))}l.layer.push(u)}return l}class Ok{constructor(e){ge(this,Fi);ge(this,Hr,0);ge(this,Vr,0);Te(this,Fi,new Array(e))}push(e){W(this,Fi)[W(this,Hr)]=e,Te(this,Hr,(W(this,Hr)+1)%this.size),Te(this,Vr,Math.min(W(this,Vr)+1,this.size))}get(){const e=W(this,Fi);return W(this,Vr)<this.size?e.slice(0,W(this,Vr)):e.slice(W(this,Hr),this.size).concat(e.slice(0,W(this,Hr)))}get size(){return W(this,Fi).length}get length(){return W(this,Vr)}}Fi=new WeakMap,Hr=new WeakMap,Vr=new WeakMap;let xi,ky=0;function _y(){return performance.now()-ky<50}function Nk(t){return function(...e){ky=performance.now(),t(...e)}}function zk(t,e,n,r,o){if(n=Nk(n),t.type=="wheel"){t.uiEvent.preventDefault();const i=t.uiEvent,s=i.deltaMode?120:1;if(!i.deltaX&&!i.deltaY)return;xi==null||xi.stop();let{x:a,y:c}=t.point;if(r){const l=r.mark.encoders;l.x&&!l.x2&&!l.x.constant&&(a=+l.x(r.datum)*e.width+e.x),l.y&&!l.y2&&!l.y.constant&&(c=(1-+l.y(r.datum))*e.height+e.y)}Math.abs(i.deltaX)<Math.abs(i.deltaY)?n({x:a,y:c,xDelta:0,yDelta:0,zDelta:i.deltaY*s/300}):n({x:a,y:c,xDelta:-i.deltaX*s,yDelta:0,zDelta:0})}else if(t.type=="mousedown"&&t.uiEvent.button===0){xi&&xi.stop();const i=new Ok(30),s=t.uiEvent;s.preventDefault();let a=Kt.fromMouseEvent(s);const c=f=>{const d=Kt.fromMouseEvent(f);i.push({point:d,timestamp:performance.now()});const h=d.subtract(a);n({x:a.x,y:a.y,xDelta:h.x,yDelta:h.y,zDelta:0}),a=d},l=()=>{const d=performance.now(),h=i.get().filter(S=>d-S.timestamp<160);if(h.length<5||!o||Uk(h))return;const p=h.at(-1),b=h[0],v=p.point.subtract(b.point).multiply(1/(p.timestamp-b.timestamp));let y=a.x,A=a.y;xi=Wh(o,S=>{n({x:S.x,y:S.y,xDelta:y-S.x,yDelta:A-S.y,zDelta:0}),y=S.x,A=S.y},150,.5,{x:y,y:A}),xi({x:a.x-v.x*250,y:a.y-v.y*250})},u=()=>{document.removeEventListener("mousemove",c),document.removeEventListener("mouseup",u),l()};document.addEventListener("mouseup",u,!1),document.addEventListener("mousemove",c,!1)}}function Uk(t){const e=t[Math.floor(t.length/2)],n=e.point.subtract(t[0].point).multiply(e.timestamp-t[0].timestamp),r=t.at(-1).point.subtract(e.point).multiply(t.at(-1).timestamp-e.timestamp),o=n.length;return r.length/o<.4}class Gk extends mo{constructor(e,n,r,o,i,s){const c={...n=="locus"?Hk:Ry,...e};super(Wk(c,n),r,o,i,`axisGrid_${e.orient}`,{blockEncodingInheritance:!0,contributesToScaleDomain:!1,...s}),this.axisProps=c}getOrient(){return this.axisProps.orient}isPickingSupported(){return!1}}const Ry={values:null,grid:!1,gridCap:"butt",gridColor:"lightgray",gridDash:null,gridOpacity:1,gridWidth:1,tickCount:null,tickMinStep:null},Hk={...Ry,chromGrid:!1,chromGridCap:"butt",chromGridColor:"gray",chromGridDash:[1,5],chromGridOpacity:1,chromGridWidth:1};function Vk(t,e){const n=t,r=Pr(n.orient);return{name:"grid_lines",data:{lazy:{type:"axisTicks",channel:r,axis:t}},mark:{type:"rule",strokeDash:n.gridDash,strokeCap:n.gridCap,color:n.gridColor,size:n.gridWidth,opacity:n.gridOpacity,minBufferSize:300},encoding:{[r]:{field:"value",type:e}}}}function qk(t,e){const n=t,r=Pr(n.orient);return{name:"chromosome_lines",data:{lazy:{type:"axisGenome",channel:r}},mark:{type:"rule",strokeDash:n.chromGridDash,strokeCap:n.chromGridCap,color:n.chromGridColor,size:n.chromGridWidth,opacity:n.chromGridOpacity},encoding:{[r]:{field:"continuousStart",type:e,band:0}}}}function jk(t,e){const n=t,r=Pr(n.orient);return{name:"chromosome_fill",data:{lazy:{type:"axisGenome",channel:r}},mark:{type:"rect"},encoding:{[r]:{field:"continuousStart",type:e,band:0},[r+"2"]:{field:"continuousEnd",band:0},fill:{field:"odd",type:"nominal",scale:{domain:[!1,!0],range:[n.chromGridFillEven??"white",n.chromGridFillOdd??"white"]}},opacity:{field:"odd",type:"nominal",scale:{type:"ordinal",domain:[!1,!0],range:[n.chromGridFillEven?1:0,n.chromGridFillOdd?1:0]}}}}}function Wk(t,e){const n={...t},r=[];return n.chromGrid&&(n.chromGridFillOdd||n.chromGridFillEven)&&r.push(jk(n,e)),n.chromGrid&&n.chromGridOpacity>0&&r.push(qk(n,e)),n.grid&&n.gridOpacity>0&&r.push(Vk(n,e)),{name:"grid_layers",configurableVisibility:!1,resolve:{scale:{[Pr(t.orient)]:"forced",fill:"independent",opacity:"independent"}},layer:r}}const Fy={anchor:"middle",frame:"group",offset:10,orient:"top",align:void 0,angle:0,baseline:"alphabetic",dx:0,dy:0,color:void 0,font:void 0,fontSize:12,fontStyle:"normal",fontWeight:"normal"},Yk={orient:"left",anchor:"middle",align:"right",baseline:"middle",angle:0,fontSize:12},Qk={orient:"top",anchor:"start",align:"left",baseline:"top",offset:-10,dx:10,fontSize:12},Zk={start:0,middle:.5,end:1},Xk={start:"left",middle:"center",end:"right"};function Kk(t){if(!t)return;const e=nt(t)?{text:t}:t;if(!e.text||e.orient=="none")return;const n={"track-title":Yk,overlay:Qk}[e.style]??{},r={...Fy,...n,...e};let o={},i={x:0,y:0};const s=Zk[r.anchor??"middle"];switch(r.orient){case"top":i={x:s,y:1},o={baseline:"alphabetic",angle:0};break;case"right":i={x:1,y:1-s},o={baseline:"alphabetic",angle:90};break;case"bottom":i={x:s,y:0},o={baseline:"top",angle:0};break;case"left":i={x:0,y:s},o={baseline:"alphabetic",angle:-90};break}const a={...Fy,...o,...n,...e},c={xOffset:0,yOffset:0};switch(r.orient){case"top":c.yOffset=-a.offset;break;case"right":c.xOffset=a.offset;break;case"bottom":c.yOffset=a.offset;break;case"left":c.xOffset=-a.offset;break}return{configurableVisibility:!1,data:{values:[{}]},mark:{type:"text",tooltip:null,clip:!1,...i,...c,text:a.text,align:a.align??Xk[a.anchor],angle:a.angle,baseline:a.baseline,dx:a.dx,dy:a.dy,color:a.color,font:a.font,size:a.fontSize,fontStyle:a.fontStyle,fontWeight:a.fontWeight}}}class My extends tn{constructor(n,r){const o={scrollbarSize:8,scrollbarPadding:2};super({data:{values:[{}]},mark:{type:"rect",fill:"#b0b0b0",fillOpacity:.6,stroke:"white",strokeWidth:1,strokeOpacity:1,cornerRadius:5,clip:!1},configurableVisibility:!1},n.layoutParent.context,n.layoutParent,n.view,"scrollbar-"+r,{blockEncodingInheritance:!0});ge(this,Jo);ge(this,Ja,Hn.ZERO);ge(this,qr,0);ge(this,Mi,0);Ut(this,"viewportOffset",0);this.config=o,Te(this,Jo,r),this.interpolateViewportOffset=Wh(this.context.animator,i=>{this.viewportOffset=i.x},50,.4,{x:this.viewportOffset}),this.addInteractionEventListener("mousedown",(i,s)=>{if(s.stopPropagation(),W(this,qr)<=0)return;const a=h=>r=="vertical"?h.clientY:h.clientX,c=s.uiEvent;c.preventDefault();const l=this.scrollOffset,u=a(c),f=h=>{const p=lo(a(h)-u+l,0,W(this,qr));this.interpolateViewportOffset({x:p/W(this,qr)*W(this,Mi)})},d=()=>{document.removeEventListener("mousemove",f),document.removeEventListener("mouseup",d)};document.addEventListener("mouseup",d,!1),document.addEventListener("mousemove",f,!1)})}get scrollOffset(){return this.viewportOffset/W(this,Mi)*W(this,qr)}render(n,r,o){super.render(n,W(this,Ja),o)}updateScrollbar(n,r){const o=this.config.scrollbarPadding,i=this.config.scrollbarSize,s=W(this,Jo)=="horizontal"?"width":"height",a=Math.min(1,n[s]/r[s]),c=n[s]-2*o,l=a*c;Te(this,qr,c-l),Te(this,Mi,r[s]-n[s]),this.viewportOffset=lo(this.viewportOffset,0,W(this,Mi)),Te(this,Ja,W(this,Jo)=="vertical"?new Hn(()=>n.x+n.width-i-o,()=>n.y+o+this.scrollOffset,()=>i,()=>l):new Hn(()=>n.x+o+this.scrollOffset,()=>n.y+n.height-i-o,()=>l,()=>i))}}Jo=new WeakMap,Ja=new WeakMap,qr=new WeakMap,Mi=new WeakMap;class Jk extends mo{constructor(e,n,r={}){const o=n(),i=Object.keys(o.intervals);if(["x","y"].every(l=>!i.includes(l)))throw new Error("SelectionRect requires at least one of the channels 'x' or 'y' to be present in the selection.");const s={name:"selectionRect",configurableVisibility:!1,resolve:{scale:{x:"forced",y:"forced"}},data:{values:Py(n())},encoding:{},layer:[]};i.includes("x")&&(s.encoding.x={field:"_x",type:null,title:null},s.encoding.x2={field:"_x2"}),i.includes("y")&&(s.encoding.y={field:"_y",type:null,title:null},s.encoding.y2={field:"_y2"}),s.layer.push({name:"selectionRectRect",mark:{type:"rect",clip:!0,fill:"#808080",fillOpacity:.05,stroke:"black",strokeWidth:1,strokeOpacity:.2,...r}});const a=l=>{const u=e.view.getScaleResolution(l);return`format(datum._${l}2 - datum._${l}, '.3s')`+(u.type==="locus"?" + 'b'":"")},c=r.measure=="inside"?9:r.measure=="outside"?-9:0;i.includes("x")&&c!=0&&s.layer.push({name:"selectionRectTextX",mark:{type:"text",align:"center",paddingX:5,dy:c,tooltip:null},encoding:{text:{expr:a("x")},y:i.includes("y")?{field:"_y2",type:null,title:null}:{value:1},y2:null}}),i.includes("y")&&c!=0&&s.layer.push({name:"selectionRectTextY",mark:{type:"text",align:"center",paddingY:5,dy:c,tooltip:null,angle:-90},encoding:{text:{expr:a("y")},x2:null}}),super(s,e.layoutParent.context,e.layoutParent,e.view,"selectionRect",{blockEncodingInheritance:!0,contributesToScaleDomain:!1}),n.addListener(()=>{const l=n();this.context.dataFlow.findDataSourceByKey(this).updateDynamicData(Py(l))})}}function Py(t){const e=t.intervals.x,n=t.intervals.y;return!e&&!n?[]:[{_x:e==null?void 0:e[0],_x2:e==null?void 0:e[1],_y:n==null?void 0:n[0],_y2:n==null?void 0:n[1]}]}class Ly{constructor(e,n,r){ge(this,uu);if(this.layoutParent=n,this.view=e,this.serial=r,this.background=void 0,this.backgroundStroke=void 0,this.axes={},this.gridLines={},this.scrollbars={},this.selectionRect=void 0,this.title=void 0,this.coords=Hn.ZERO,e.needsAxes.x||e.needsAxes.y){const o=e.spec,i="view"in o?o==null?void 0:o.view:void 0,s=$k(i);s&&(this.background=new tn(s,n.context,n,e,"background"+r,{blockEncodingInheritance:!0}));const a=e_(i);a&&(this.backgroundStroke=new tn(a,n.context,n,e,"backgroundStroke"+r,{blockEncodingInheritance:!0}));const c=Kk(e.spec.title);if(c){const l=new tn(c,n.context,n,e,"title"+r,{blockEncodingInheritance:!0});this.title=l}}e.spec.viewportWidth!=null&&(this.scrollbars.horizontal=new My(this,"horizontal")),e.spec.viewportHeight!=null&&(this.scrollbars.vertical=new My(this,"vertical")),de(this,uu,wv).call(this)}*getChildren(){this.background&&(yield this.background),this.backgroundStroke&&(yield this.backgroundStroke),this.title&&(yield this.title),yield*Object.values(this.axes),yield*Object.values(this.gridLines),yield this.view,yield*Object.values(this.scrollbars),this.selectionRect&&(yield this.selectionRect)}async createAxes(){const{view:e,axes:n,gridLines:r}=this,o=(a,c)=>{const l=a.getAxisProps();if(l===null)return;const u=l?{...l}:{};if(!u.orient){for(const f of _l[c])if(!n[f]){u.orient=f;break}if(!u.orient)throw new Error("No slots available for an axis! Perhaps a LayerView has more than two children?")}if(u.title??(u.title=a.getTitle()),!_l[c].includes(u.orient))throw new Error(`Invalid axis orientation "${u.orient}" on channel "${c}"!`);return u},i=async(a,c,l)=>{const u=o(a,c);if(u){if(n[u.orient])throw new Error(`An axis with the orient "${u.orient}" already exists!`);const f=new Ty(u,a.scaleResolution.type,this.layoutParent.context,this.layoutParent,l);n[u.orient]=f,await f.initializeChildren()}},s=async(a,c,l)=>{const u=o(a,c);if(u&&(u.grid||u.chromGrid)){const f=new Gk(u,a.scaleResolution.type,this.layoutParent.context,this.layoutParent,l);r[u.orient]=f,await f.initializeChildren()}};for(const a of["x","y"])if(e.needsAxes[a]){const c=e.resolutions.axis[a];if(!c)continue;await i(c,a,e)}for(const a of["x","y"])if(e.needsAxes[a]&&e.getConfiguredOrDefaultResolution(a,"axis")!="excluded"){const c=e.getAxisResolution(a);if(!c)continue;await s(c,a,e)}if(e instanceof mo){for(const a of e)for(const[c,l]of Object.entries(a.resolutions.axis)){const u=l.getAxisProps();u&&u.orient&&await i(l,c,a)}for(const a of e)for(const[c,l]of Object.entries(a.resolutions.axis)){const u=l.getAxisProps();u&&!u.orient&&await i(l,c,a)}}[...Object.values(n),...Object.values(r)].forEach(a=>a.visit(c=>{c instanceof tn&&c.resolve("scale")}))}getOverhang(){const e=n=>{const r=this.axes[n];return r?Math.max(r.getPerpendicularSize()+(r.axisProps.offset??0),0):0};return new Ot(e("top"),e("right"),e("bottom"),e("left")).add(this.view.getOverhang())}getOverhangAndPadding(){return this.getOverhang().add(this.view.getPadding())}}uu=new WeakSet,wv=function(){const e=this.view,n=r=>{this.view.context.glHelper.canvas.style.cursor=r};for(const[r,o]of e.paramMediator.paramConfigs){if(!("select"in o))continue;const i=wl(o.select);if(!J1(i))continue;const s=i.encodings,a=Object.fromEntries(s.map(S=>{const E=this.view.getScaleResolution(S),I=E==null?void 0:E.scale;if(!I||!kt(I.type))throw new Error(`No continuous scale found for interval selection param "${r}" on channel "${S}"! Scale type is "${(I==null?void 0:I.type)??"none"}".`);return[S,E]}));if(this.selectionRect)throw new Error("Only one interval selection per container is currently allowed!");let c=!1,l=!1,u=!1,f=null;const d=(S,E)=>Object.fromEntries(s.map(I=>[I,[Math.min(S[I],E[I]),Math.max(S[I],E[I])]])),h=e.paramMediator.createExpression(r),p=e.paramMediator.getSetter(r);o.value&&p({type:"interval",intervals:o.value});const b=()=>{p(Q1(s)),n(null)};this.selectionRect=new Jk(this,h,i.mark),this.selectionRect.initializeChildren();const v=S=>{const E={x:0,y:0},I=e.coords.normalizePoint(S.x,S.y,!0);for(const _ of s){const B=a[_].scale,N=B.invert(_=="x"?I.x:I.y);E[_]=N+(["index","locus"].includes(B.type)?.5:0)}return E},y=S=>{var N,M,F,C;const{intervals:E}=S,I=(Y,Q,se)=>{const oe=(ye,he)=>he==null?null:a[ye].scale(he),ae=oe("x",Y)??se,ce=oe("y",Q)??se;return e.coords.denormalizePoint(ae,ce,!0)},_=I((N=E.x)==null?void 0:N[0],(M=E.y)==null?void 0:M[0],0),B=I((F=E.x)==null?void 0:F[1],(C=E.y)==null?void 0:C[1],1);return Hn.create(_.x,_.y,B.x-_.x,B.y-_.y)};e.addInteractionEventListener("mousedown",(S,E)=>{if(E.uiEvent.button!=0)return;if(f=c?y(h()):null,f)n("grabbing"),l=!0;else{const M=E.point;if($1(h())&&(l=!0),E.uiEvent.shiftKey)b(),u=!0;else if($1(h())){const F=(C,Y)=>{e.removeInteractionEventListener("mouseup",F);const Q=Y.point;M.subtract(Q).length<2&&b()};e.addInteractionEventListener("mouseup",F);return}}E.stopPropagation();const I=E.point,_=Kt.fromMouseEvent(E.uiEvent).subtract(I),B=M=>{const F=Kt.fromMouseEvent(M).subtract(_);let C;if(f){const Y=F.subtract(I),Q=f.translate(Y.x,Y.y);C=d(v(new Kt(Q.x,Q.y)),v(new Kt(Q.x2,Q.y2)))}else C=d(v(I),v(F));for(const Y of s){const Q=a[Y],{zoomExtent:se,scale:oe}=Q,ae=C[Y];if(["index","locus"].includes(oe.type)&&(ae[0]=Math.ceil(ae[0]),ae[1]=Math.ceil(ae[1])),f){const ce=ae[1]-ae[0],ye=se[0],he=se[1];ae[0]<ye&&(ae[0]=ye,ae[1]=ye+ce),ae[1]>he&&(ae[1]=he,ae[0]=he-ce)}else ae[0]=Math.max(se[0],ae[0]),ae[1]=Math.min(se[1],ae[1]);ae[1]=Math.min(se[1],ae[1])}p({type:"interval",intervals:C})},N=()=>{document.removeEventListener("mousemove",B),document.removeEventListener("mouseup",N),u=!1,f&&(n("move"),f=null)};document.addEventListener("mousemove",B),document.addEventListener("mouseup",N)}),e.addInteractionEventListener("click",(S,E)=>{E.uiEvent.button==0&&l&&(E.stopPropagation(),l=!1)},!0);const A=S=>CI(h(),v(S));e.addInteractionEventListener("dblclick",(S,E)=>{A(E.point)&&(b(),E.stopPropagation())},!0),e.addInteractionEventListener("mousemove",(S,E)=>{A(E.point)?u||(c=!0,f||n("move")):(c=!1,f||n(null))})}};function $k(t){if(t!=null&&t.fill||t!=null&&t.fillOpacity||t!=null&&t.shadowOpacity)return{configurableVisibility:!1,data:{values:[{}]},mark:{color:t.fill,opacity:t.fillOpacity??(t.fill?1:0),type:"rect",clip:!1,tooltip:null,minHeight:1,minOpacity:0,shadowBlur:t.shadowBlur,shadowColor:t.shadowColor,shadowOffsetX:t.shadowOffsetX,shadowOffsetY:t.shadowOffsetY,shadowOpacity:t.shadowOpacity}}}function e_(t){if(!(!t||!t.stroke||t.strokeWidth===0||t.strokeOpacity===0))return{configurableVisibility:!1,resolve:{scale:{x:"excluded",y:"excluded"},axis:{x:"excluded",y:"excluded"}},data:{values:[{x:0,y:0,x2:1,y2:0},{x:1,y:0,x2:1,y2:1},{x:1,y:1,x2:0,y2:1},{x:0,y:1,x2:0,y2:0}]},mark:{size:t.strokeWidth??1,color:t.stroke??"lightgray",strokeCap:"square",opacity:t.strokeOpacity??1,type:"rule",clip:!1,tooltip:null},encoding:{x:{field:"x",type:"quantitative",scale:null},y:{field:"y",type:"quantitative",scale:null},x2:{field:"x2"},y2:{field:"y2"}}}}class t_ extends xa{constructor(n,r,o,i,s,a,c){super(n,r,o,i,s,c);ge(this,He);ge(this,$o,1/0);ge(this,es,10);ge(this,rn,[]);ge(this,Pi,{});ge(this,ts,0);this.spec=n,Te(this,es,n.spacing??10),Te(this,$o,a),Te(this,rn,[]),this.wrappingFacet=!1}appendChild(n){n.layoutParent??(n.layoutParent=this),W(this,rn).push(new Ly(n,this,W(this,ts))),cv(this,ts)._++}setChildren(n){Te(this,rn,[]);for(const r of n)this.appendChild(r)}replaceChild(n,r){const o=W(this,rn).findIndex(i=>i.view==n);if(o>=0)W(this,rn)[o]=new Ly(r,this,W(this,ts));else throw new Error("Not my child view!")}get children(){return W(this,rn).map(n=>n.view)}get childCount(){return W(this,rn).length}async createAxes(){const n=[];for(const r of uo){const o=this.resolutions.axis[r];if(o){const i=o.getAxisProps();if(i){const s={title:o.getTitle(),orient:_l[r][0],...i},a=new Ty(s,o.scaleResolution.type,this.context,this,this);n.push(a.initializeChildren()),W(this,Pi)[r]=a}}}return Promise.all([...n,...W(this,rn).map(r=>r.createAxes())])}*[Symbol.iterator](){for(const n of W(this,rn))yield*n.getChildren();for(const n of Object.values(W(this,Pi)))yield n}getOverhang(){return de(this,He,vv).call(this).union(de(this,He,du).call(this))}getSize(){return this._cache("size",()=>new Mr(de(this,He,_0).call(this,"column"),de(this,He,_0).call(this,"row")).addPadding(de(this,He,du).call(this)))}render(n,r,o={}){if(super.render(n,r,o),!this.isConfiguredVisible())return;this.layoutParent||(r=r.shrink(this.getPadding())),r=r.shrink(de(this,He,du).call(this)),n.pushView(this,r);const i={devicePixelRatio:this.context.devicePixelRatio},s=$b(de(this,He,k0).call(this,"column"),r.width,i),a=$b(de(this,He,k0).call(this,"row"),r.height,i),c=new Iy(W(this,He,Oi).length,W(this,$o)??1/0),l=u=>Math.round(u*devicePixelRatio)/devicePixelRatio;for(const[u,f]of 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ee=q=="left"||q=="right"?"vertical":"horizontal",J=f.scrollbars[ee],fe=J?we.modify(ee=="vertical"?{y:()=>Ie.y,height:ae}:{x:()=>Ie.x,width:oe}):we,L=Oy(fe,q,j);let D=o.clipRect;J&&(D=L.intersect(D).intersect(J?we.modify(ee=="vertical"?{x:-1e5,width:2e5}:{y:-1e5,height:2e5}):void 0)),j.render(n,L,{...o,clipRect:D})}for(const q of Object.values(W(this,Pi))){const ee=q.axisProps.orient;(ee=="left"&&S==0||ee=="right"&&S==c.nCols-1||ee=="top"&&E==0||ee=="bottom"&&E==c.nRows-1)&&q.render(n,Oy(we.shrink(f.view.getOverhang()),ee,q),o)}Ve||d.render(n,Ie,o),A==null||A.render(n,Ie,o);for(const q of Object.values(f.scrollbars))q.updateScrollbar(we,Ie),q.render(n,r,o);y==null||y.render(n,we,o)}n.popView(this)}propagateInteractionEvent(n){if(this.handleInteractionEvent(void 0,n,!0),n.stopped)return;const r=W(this,He,Oi).find(i=>i.coords.containsPoint(n.point.x,n.point.y));for(const i of Object.values((r==null?void 0:r.scrollbars)??{}))if(i.coords.containsPoint(n.point.x,n.point.y)&&(i.propagateInteractionEvent(n),n.stopped))return;const o=r==null?void 0:r.view;if(o){if(o.propagateInteractionEvent(n),n.stopped)return;(o instanceof tn||o instanceof mo)&&zk(n,r.coords,i=>de(this,He,Av).call(this,r.coords,r.view,i),this.context.getCurrentHover(),this.context.animator)}n.stopped||this.handleInteractionEvent(void 0,n,!1)}getDefaultResolution(n,r){return"independent"}}$o=new WeakMap,es=new WeakMap,rn=new WeakMap,Pi=new WeakMap,ts=new WeakMap,He=new WeakSet,Oi=function(){return W(this,rn).filter(n=>n.view.isConfiguredVisible())},xv=function(){return new Iy(W(this,He,Oi).length,W(this,$o)??1/0)},nc=function(n){const r=n=="column"?"width":"height",o=(i,s)=>i.map(a=>{const l=W(this,He,Oi)[a].getOverhangAndPadding();return n=="column"?s?l.right:l.left:s?l.bottom:l.top}).reduce((a,c)=>Math.max(a,c),0);return this._cache(`size/directionSizes/${n}`,()=>W(this,He,xv)[n=="column"?"colIndices":"rowIndices"].map(i=>({axisBefore:o(i,0),axisAfter:o(i,1),view:zD(i.map(s=>W(this,He,Oi)[s].view.getViewportSize()[r]))})))},k0=function(n){const r=de(this,He,nc).call(this,n),o=[];o.push(ma);for(const[i,s]of r.entries())i>0&&o.push({px:W(this,es),grow:0}),(i==0||this.wrappingFacet)&&o.push(ma),o.push({px:s.axisBefore,grow:0}),o.push(s.view),o.push({px:s.axisAfter,grow:0}),(i==r.length-1||this.wrappingFacet)&&o.push(ma);return o},_0=function(n){let r=0,o=0;const i=n=="row"?this.spec.height:this.spec.width;if(i||i===0)return ty(i);const s=de(this,He,nc).call(this,n);for(const[a,c]of s.entries())a>0&&(o+=W(this,es)),(a==0||this.wrappingFacet)&&(o+=0),o+=c.axisBefore,o+=c.view.px??0,r+=c.view.grow??0,o+=c.axisAfter,(a==s.length-1||this.wrappingFacet)&&(o+=0);return{px:o,grow:r}},R0=function(n,r){return n=="row"&&this.wrappingFacet?1+6*r+2:2+4*r+1},vv=function(){const n=de(this,He,nc).call(this,"column"),r=de(this,He,nc).call(this,"row");return!n.length||!r.length?Ot.zero():new Ot(r.at(0).axisBefore,n.at(-1).axisAfter,r.at(-1).axisAfter,n.at(0).axisBefore)},du=function(){const n=r=>{const o=Qh[r],i=W(this,Pi)[o];return(i==null?void 0:i.axisProps.orient)!==r?0:Math.max(i.getPerpendicularSize()+(i.axisProps.offset??0),0)};return new Ot(n("top"),n("right"),n("bottom"),n("left"))},Av=function(n,r,o){for(const[i,s]of Object.entries(n_(r))){if(s.size<=0)continue;const a=n.normalizePoint(o.x,o.y),c=n.normalizePoint(o.x+o.xDelta,o.y+o.yDelta),l={x:c.x-a.x,y:c.y-a.y};for(const u of s)u.zoom(2**o.zDelta,i=="y"?1-a[i]:a[i],i=="x"?l.x:-l.y)}this.context.animator.requestRender()};function n_(t){const e={x:new Set,y:new Set};return t.visit(n=>{for(const[r,o]of Object.entries(e)){const i=n.getScaleResolution(r);i&&i.isZoomable()&&o.add(i)}}),e}function r_(t){let e=!0;return t.visit(n=>{n instanceof tn&&e&&(e=n.mark.properties.clip===!0)}),e}function Oy(t,e,n){const r=n.axisProps,o=n.getPerpendicularSize();if(e=="bottom")return t.translate(0,t.height+r.offset).modify({height:o});if(e=="top")return t.translate(0,-o-r.offset).modify({height:o});if(e=="left")return t.translate(-o-r.offset,0).modify({width:o});if(e=="right")return t.translate(t.width+r.offset,0).modify({width:o})}class Xh extends t_{constructor(e,n,r,o,i){super(e,n,r,o,i,$h(e)?e.columns:Rl(e)?1:1/0),this.spec=e}async initializeChildren(){const e=this.spec,n=$h(e)?e.concat:Rl(e)?e.vconcat:e.hconcat;this.setChildren(await Promise.all(n.map((r,o)=>this.context.createOrImportView(r,this,this,"grid"+o)))),await this.createAxes()}getDefaultResolution(e,n){return n=="axis"?"independent":Rl(this.spec)&&e==="x"||Uy(this.spec)&&e==="y"?"shared":"independent"}}const Ny="viewRoot";class i_{constructor(e={}){ge(this,ns,new Map);this.options={allowImport:!0,wrapRoot:!0,...e};const n=r=>(o,i,s,a,c)=>new r(o,i,s,a,o.name??c);this.addViewType(Jh,n(mo)),this.addViewType(Kh,n(tn)),this.addViewType(Rl,n(Xh)),this.addViewType(Uy,n(Xh)),this.addViewType($h,n(Xh)),this.addViewType(a_,()=>{throw new Error("SampleView is not supported by the @genome-spy/core package. Use @genome-spy/app instead!")})}addViewType(e,n){W(this,ns).set(e,n)}createView(e,n,r,o,i){for(const[s,a]of W(this,ns))if(s(e))return a(e,n,r,o,i);throw new Error("Invalid spec, cannot figure out the view type from the properties: "+JSON.stringify([...Object.keys(e)]))}isViewSpec(e){const n=[...W(this,ns).keys()].filter(r=>r(e));if(n.length>1)throw new Error("Ambiguous spec. Cannot create a view!");return n.length==1}async createOrImportView(e,n,r,o,i,s){let a;if(s_(e)){let u;if("url"in e.import)if(this.options.allowImport)u=await lk(e,o.getBaseUrl(),n);else throw new Fr("Importing views is not allowed!",r);else if("template"in e.import)u=zy(e.import.template,o);else throw new Error("Invalid import: "+JSON.stringify(e));s==null||s(u),o_(u,e),a=u}else a=e;const c=u=>{var f;return(f=u==null?void 0:u.params)==null?void 0:f.some(d=>tb(d)&&wl(d.select).type=="interval")};!o&&this.options.wrapRoot&&(Kh(a)||Jh(a)||c(a))&&i===Ny&&(a={name:"implicitRoot",vconcat:[a]});const l=this.createView(a,n,r,o,i);return l instanceof xa&&await l.initializeChildren(),l}}ns=new WeakMap;function zy(t,e){var r,o;const n=(o=(r=e.spec)==null?void 0:r.templates)==null?void 0:o[t];if(n)return structuredClone(n);if(e.dataParent)return zy(t,e.dataParent);throw new Error(`Cannot find template "${t}" in current view or its ancestors!`)}function o_(t,e){e.name!=null&&(t.name=e.name);const n=Dt(e.params)?e.params:Ft(e.params)?Object.entries(e.params).map(([r,o])=>({name:r,value:o})):[];if(n.length){t.params??(t.params=[]);for(const r of n){const o=t.params.findIndex(i=>i.name==r.name);o>=0&&(t.params[o]=r)}for(const r of n)t.params.some(o=>o.name==r.name)||t.params.push(r)}}function Kh(t){return"mark"in t&&(nt(t.mark)||Ft(t.mark))}function Jh(t){return"layer"in t&&Ft(t.layer)}function s_(t){return"import"in t}function Rl(t){return"vconcat"in t&&Dt(t.vconcat)}function Uy(t){return"hconcat"in t&&Dt(t.hconcat)}function $h(t){return"concat"in t&&Dt(t.concat)}function a_(t){return"samples"in t&&Ft(t.samples)&&"spec"in t&&Ft(t.spec)}function c_(t){const e=Math.floor(Math.random()*16777215).toString(16),n=[];for(const r of t.paramConfigs.values()){if(!kI(r))continue;const o=r.bind;if(!o||!("input"in o))continue;const i=r.name,s=t.getSetter(i),a=t.getValue(i),c=o.name??i,l=o.debounce?Bl(s,o.debounce,!1):s,u=`${e}-param-${i}`;if(o.input=="range")n.push(ot`<label for=${u}>${c}</label>
|
|
585
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+
`:"";return ot`${c}${s}`}class xa extends ry{constructor(e,n,r,o,i,s){super(e,n,r,o,i,s),this.spec=e}async initializeChildren(){}*[Symbol.iterator](){}replaceChild(e,n){throw new Error("Not implemented")}visit(e){let n;try{n=e(this)}catch(r){throw r.view=this,r}if(n===ya)return n;if(n!==HD){e.beforeChildren&&e.beforeChildren(this);for(const r of this){const o=r.visit(e);if(o===ya)return o}e.afterChildren&&e.afterChildren(this),e.postOrder&&e.postOrder(this)}}findDescendantByPath(e){for(const n of this)if(n.name===e[0]){if(e.length==1)return n;if(n instanceof xa)return n.findDescendantByPath(e.slice(1))}}findChildByName(e){for(const n of this)if(n.name===e)return n}findDescendantByName(e){let n;return this.visit(r=>{if(r.name==e)return n=r,ya}),n}getDefaultResolution(e,n){return"shared"}}class mo extends xa{constructor(n,r,o,i,s,a){super(n,r,o,i,s,{layersChildren:!0,...a});ge(this,sr,[]);this.spec=n,this.needsAxes={x:!0,y:!0}}async initializeChildren(){Te(this,sr,await Promise.all(this.spec.layer.map((n,r)=>this.context.createOrImportView(n,this,this,"grid"+r,o=>{if(!Jh(o)&&!Kh(o))throw new Fr("LayerView accepts only unit or layer specs as children!",this)}))))}get children(){return W(this,sr).slice()}*[Symbol.iterator](){for(const n of W(this,sr))yield n}render(n,r,o={}){if(super.render(n,r,o),!!this.isConfiguredVisible()){n.pushView(this,r);for(const i of W(this,sr))i.render(n,r,o);n.popView(this)}}propagateInteractionEvent(n){this.handleInteractionEvent(void 0,n,!0);for(let r=W(this,sr).length-1;r>=0;r--)if(W(this,sr)[r].propagateInteractionEvent(n),n.stopped)return;this.handleInteractionEvent(void 0,n,!1)}}sr=new WeakMap;class Iy{constructor(e,n){this.n=e,this.maxCols=n??1/0}get nRows(){return this.maxCols==1/0?1:Math.ceil(this.n/this.maxCols)}get nCols(){return Math.min(this.n,this.maxCols)}get rowIndices(){const e=[],n=this.nCols,r=this.nRows;for(let o=0;o<r;o++){const i=[];e.push(i);for(let s=0;s<n;s++){const a=o*n+s;a<this.n&&i.push(a)}}return e}get colIndices(){const e=[],n=this.nCols,r=this.nRows;for(let o=0;o<n;o++){const i=[];e.push(i);for(let s=0;s<r;s++){const a=s*n+o;a<this.n&&i.push(a)}}return e}getCellIndex(e,n){let r=0;if(this.maxCols==1/0)r=n==0?e:void 0;else{if(e>=this.maxCols)return;r=n*this.nCols+e}return r<this.n?r:void 0}getCellCoords(e){if(!(e<0||e>=this.n))return[e%this.nCols,Math.floor(e/this.nCols)]}}const Rk="chromosome_ticks_and_labels",Fk={x:"width",y:"height"};function Yh(t){return t=="x"?"y":"x"}const _l={x:["bottom","top"],y:["left","right"]},Qh=Object.fromEntries(Object.entries(_l).map(([t,e])=>e.map(n=>[n,t])).flat(1));function Pr(t){return Qh[t]}class Ty extends mo{constructor(e,n,r,o,i,s){const a=n=="locus",c={...a?Pk:Dy,...Mk(n,e),...e};super(a?Lk(c,n):By(c,n),r,o,i,`axis_${e.orient}`,{blockEncodingInheritance:!0,contributesToScaleDomain:!1,...s}),this.axisProps=c}getSize(){const e={px:this.getPerpendicularSize()},n={grow:1};return Qh[this.axisProps.orient]=="x"?new Mr(n,e):new Mr(e,n)}getPerpendicularSize(){return Zh(this.axisProps)}isPickingSupported(){return!1}}function Zh(t){const e=Pr(t.orient);let n=t.ticks&&t.tickSize||0;return t.labels&&(n+=t.labelPadding,e=="x"?n+=t.labelFontSize:n+=30),t.title&&(n+=t.titlePadding+t.titleFontSize),n=Math.min(t.maxExtent||1/0,Math.max(t.minExtent||0,n)),n}const Dy={values:null,minExtent:20,maxExtent:1/0,offset:0,domain:!0,domainWidth:1,domainColor:"gray",domainDash:null,domainDashOffset:0,domainCap:"square",ticks:!0,tickSize:5,tickWidth:1,tickColor:"gray",tickDash:null,tickDashOffset:0,tickCap:"square",tickCount:null,tickMinStep:null,labels:!0,labelAlign:"center",labelBaseline:"middle",labelPadding:4,labelFontSize:10,labelLimit:180,labelColor:"black",format:null,titleColor:"black",titleFont:"sans-serif",titleFontSize:10,titlePadding:3};function Mk(t,e){const n=e.orient,r=t=="nominal"||t=="ordinal";let o="center",i="middle",s=e.labelAngle??((n=="top"||n=="bottom")&&r?-90:0);switch(n){case"left":o="right";break;case"right":o="left";break;case"top":case"bottom":Math.abs(s)>30?(o=s>0==(n=="bottom")?"left":"right",i="middle"):i=n=="top"?"alphabetic":"top";break}return{labelAlign:o,labelAngle:s,labelBaseline:i}}function By(t,e){const n={...t,extent:Zh(t)},r=Pr(n.orient),o=Yh(r),i=n.orient=="bottom"||n.orient=="right"?1:-1,s=n.orient=="bottom"||n.orient=="left"?1:0,a=()=>({name:"domain",data:{values:[{}]},mark:{type:"rule",clip:!1,strokeDash:n.domainDash,strokeCap:n.domainCap,color:n.domainColor,[o]:s,size:n.domainWidth}}),c=()=>({name:"labels",mark:{type:"text",clip:!1,align:n.labelAlign,angle:n.labelAngle,baseline:n.labelBaseline,[o+"Offset"]:(n.tickSize+n.labelPadding)*i,[o]:s,size:n.labelFontSize,color:n.labelColor,minBufferSize:1500},encoding:{[r]:{field:"value",type:e},text:{field:"label"}}}),l=()=>({name:"ticks",mark:{type:"rule",clip:!1,strokeDash:n.tickDash,strokeCap:n.tickCap,color:n.tickColor,size:n.tickWidth,minBufferSize:300},encoding:{[o]:{value:s},[o+"2"]:{value:s-n.tickSize/n.extent*(s?1:-1)}}}),u=()=>({name:"title",data:{values:[{}]},mark:{type:"text",clip:!1,align:"center",baseline:n.orient=="bottom"?"bottom":"top",angle:[0,90,0,-90][["top","right","bottom","left"].indexOf(n.orient)],text:n.title,color:n.titleColor,[r]:.5,[o]:1-s}}),f=()=>{const h={name:"ticks_and_labels",encoding:{[r]:{field:"value",type:e}},layer:[]};return n.ticks&&h.layer.push(l()),n.labels&&h.layer.push(c()),h},d={resolve:{scale:{[r]:"forced"}},[Fk[Yh(r)]]:n.extent,data:{lazy:{type:"axisTicks",channel:r,axis:t}},layer:[]};return n.domain&&d.layer.push(a()),(n.ticks||n.labels)&&d.layer.push(f()),n.title&&d.layer.push(u()),d}const Pk={...Dy,chromTicks:!0,chromTickSize:18,chromTickWidth:1,chromTickColor:"#989898",chromTickDash:[4,2],chromTickDashOffset:1,chromLabels:!0,chromLabelFontSize:13,chromLabelFontWeight:"normal",chromLabelFontStyle:"normal",chromLabelColor:"black",chromLabelAlign:"left",chromLabelPadding:7};function Lk(t,e){const n={...t,extent:Zh(t)},r=Pr(n.orient),o=Yh(r),i=n.orient=="bottom"||n.orient=="left"?1:0,s=()=>({name:"chromosome_ticks",mark:{type:"rule",strokeDash:t.chromTickDash,strokeDashOffset:t.chromTickDashOffset,[o]:i,[o+"2"]:i-n.chromTickSize/n.extent*(i?1:-1),color:t.chromTickColor,size:n.chromTickWidth}}),a=()=>{let u;switch(n.orient){case"top":u={y:0,angle:0,paddingX:4,dy:-n.chromLabelPadding,viewportEdgeFadeWidthLeft:20,viewportEdgeFadeWidthRight:20,viewportEdgeFadeDistanceRight:-10,viewportEdgeFadeDistanceLeft:-20};break;case"bottom":u={y:1,angle:0,paddingX:4,dy:n.chromLabelPadding+n.chromLabelFontSize*.73,viewportEdgeFadeWidthLeft:20,viewportEdgeFadeWidthRight:20,viewportEdgeFadeDistanceRight:-10,viewportEdgeFadeDistanceLeft:-20};break;case"left":u={x:1,angle:-90,paddingY:4,dy:-n.chromLabelPadding,viewportEdgeFadeWidthBottom:20,viewportEdgeFadeWidthTop:20,viewportEdgeFadeDistanceBottom:-20,viewportEdgeFadeDistanceTop:-10};break;case"right":u={x:0,angle:90,align:"right",paddingY:4,dy:-n.chromLabelPadding};break;default:u={}}return{name:"chromosome_labels",mark:{type:"text",size:n.chromLabelFontSize,font:n.chromLabelFont,fontWeight:n.chromLabelFontWeight,fontStyle:n.chromLabelFontStyle,color:n.chromLabelColor,align:t.chromLabelAlign,baseline:"alphabetic",clip:!1,...u},encoding:{[r+"2"]:{field:"continuousEnd",type:e},text:{field:"name"}}}};let c;switch(n.orient){case"bottom":case"top":c={};break;case"left":c={labelAngle:-90,labelAlign:"center",labelPadding:6};break;case"right":c={labelAngle:90,labelAlign:"center",labelPadding:6};break;default:c={}}const l=By({...t,...c},e);if(t.chromTicks||t.chromLabels){const u={name:Rk,data:{lazy:{type:"axisGenome",channel:Pr(n.orient)}},encoding:{[r]:{field:"continuousStart",type:e,band:0}},layer:[]};if(t.chromTicks&&u.layer.push(s()),t.chromLabels){u.layer.push(a());let f;l.layer.filter(d=>d.name=="ticks_and_labels").forEach(d=>d.layer.filter(h=>h.name=="labels").forEach(h=>{f=h.mark})),f&&(n.orient=="top"||n.orient=="bottom"?(f.viewportEdgeFadeWidthLeft=30,f.viewportEdgeFadeDistanceLeft=40):(f.viewportEdgeFadeWidthBottom=30,f.viewportEdgeFadeDistanceBottom=40))}l.layer.push(u)}return l}class Ok{constructor(e){ge(this,Fi);ge(this,Hr,0);ge(this,Vr,0);Te(this,Fi,new Array(e))}push(e){W(this,Fi)[W(this,Hr)]=e,Te(this,Hr,(W(this,Hr)+1)%this.size),Te(this,Vr,Math.min(W(this,Vr)+1,this.size))}get(){const e=W(this,Fi);return W(this,Vr)<this.size?e.slice(0,W(this,Vr)):e.slice(W(this,Hr),this.size).concat(e.slice(0,W(this,Hr)))}get size(){return W(this,Fi).length}get length(){return W(this,Vr)}}Fi=new WeakMap,Hr=new WeakMap,Vr=new WeakMap;let xi,ky=0;function _y(){return performance.now()-ky<50}function Nk(t){return function(...e){ky=performance.now(),t(...e)}}function zk(t,e,n,r,o){if(n=Nk(n),t.type=="wheel"){t.uiEvent.preventDefault();const i=t.uiEvent,s=i.deltaMode?120:1;if(!i.deltaX&&!i.deltaY)return;xi==null||xi.stop();let{x:a,y:c}=t.point;if(r){const l=r.mark.encoders;l.x&&!l.x2&&!l.x.constant&&(a=+l.x(r.datum)*e.width+e.x),l.y&&!l.y2&&!l.y.constant&&(c=(1-+l.y(r.datum))*e.height+e.y)}Math.abs(i.deltaX)<Math.abs(i.deltaY)?n({x:a,y:c,xDelta:0,yDelta:0,zDelta:i.deltaY*s/300}):n({x:a,y:c,xDelta:-i.deltaX*s,yDelta:0,zDelta:0})}else if(t.type=="mousedown"&&t.uiEvent.button===0){xi&&xi.stop();const i=new Ok(30),s=t.uiEvent;s.preventDefault();let a=Kt.fromMouseEvent(s);const c=f=>{const d=Kt.fromMouseEvent(f);i.push({point:d,timestamp:performance.now()});const h=d.subtract(a);n({x:a.x,y:a.y,xDelta:h.x,yDelta:h.y,zDelta:0}),a=d},l=()=>{const d=performance.now(),h=i.get().filter(S=>d-S.timestamp<160);if(h.length<5||!o||Uk(h))return;const p=h.at(-1),b=h[0],v=p.point.subtract(b.point).multiply(1/(p.timestamp-b.timestamp));let y=a.x,A=a.y;xi=Wh(o,S=>{n({x:S.x,y:S.y,xDelta:y-S.x,yDelta:A-S.y,zDelta:0}),y=S.x,A=S.y},150,.5,{x:y,y:A}),xi({x:a.x-v.x*250,y:a.y-v.y*250})},u=()=>{document.removeEventListener("mousemove",c),document.removeEventListener("mouseup",u),l()};document.addEventListener("mouseup",u,!1),document.addEventListener("mousemove",c,!1)}}function Uk(t){const e=t[Math.floor(t.length/2)],n=e.point.subtract(t[0].point).multiply(e.timestamp-t[0].timestamp),r=t.at(-1).point.subtract(e.point).multiply(t.at(-1).timestamp-e.timestamp),o=n.length;return r.length/o<.4}class Gk extends mo{constructor(e,n,r,o,i,s){const c={...n=="locus"?Hk:Ry,...e};super(Wk(c,n),r,o,i,`axisGrid_${e.orient}`,{blockEncodingInheritance:!0,contributesToScaleDomain:!1,...s}),this.axisProps=c}getOrient(){return this.axisProps.orient}isPickingSupported(){return!1}}const Ry={values:null,grid:!1,gridCap:"butt",gridColor:"lightgray",gridDash:null,gridOpacity:1,gridWidth:1,tickCount:null,tickMinStep:null},Hk={...Ry,chromGrid:!1,chromGridCap:"butt",chromGridColor:"gray",chromGridDash:[1,5],chromGridOpacity:1,chromGridWidth:1};function Vk(t,e){const n=t,r=Pr(n.orient);return{name:"grid_lines",data:{lazy:{type:"axisTicks",channel:r,axis:t}},mark:{type:"rule",strokeDash:n.gridDash,strokeCap:n.gridCap,color:n.gridColor,size:n.gridWidth,opacity:n.gridOpacity,minBufferSize:300},encoding:{[r]:{field:"value",type:e}}}}function qk(t,e){const n=t,r=Pr(n.orient);return{name:"chromosome_lines",data:{lazy:{type:"axisGenome",channel:r}},mark:{type:"rule",strokeDash:n.chromGridDash,strokeCap:n.chromGridCap,color:n.chromGridColor,size:n.chromGridWidth,opacity:n.chromGridOpacity},encoding:{[r]:{field:"continuousStart",type:e,band:0}}}}function jk(t,e){const n=t,r=Pr(n.orient);return{name:"chromosome_fill",data:{lazy:{type:"axisGenome",channel:r}},mark:{type:"rect"},encoding:{[r]:{field:"continuousStart",type:e,band:0},[r+"2"]:{field:"continuousEnd",band:0},fill:{field:"odd",type:"nominal",scale:{domain:[!1,!0],range:[n.chromGridFillEven??"white",n.chromGridFillOdd??"white"]}},opacity:{field:"odd",type:"nominal",scale:{type:"ordinal",domain:[!1,!0],range:[n.chromGridFillEven?1:0,n.chromGridFillOdd?1:0]}}}}}function Wk(t,e){const n={...t},r=[];return n.chromGrid&&(n.chromGridFillOdd||n.chromGridFillEven)&&r.push(jk(n,e)),n.chromGrid&&n.chromGridOpacity>0&&r.push(qk(n,e)),n.grid&&n.gridOpacity>0&&r.push(Vk(n,e)),{name:"grid_layers",configurableVisibility:!1,resolve:{scale:{[Pr(t.orient)]:"forced",fill:"independent",opacity:"independent"}},layer:r}}const Fy={anchor:"middle",frame:"group",offset:10,orient:"top",align:void 0,angle:0,baseline:"alphabetic",dx:0,dy:0,color:void 0,font:void 0,fontSize:12,fontStyle:"normal",fontWeight:"normal"},Yk={orient:"left",anchor:"middle",align:"right",baseline:"middle",angle:0,fontSize:12},Qk={orient:"top",anchor:"start",align:"left",baseline:"top",offset:-10,dx:10,fontSize:12},Zk={start:0,middle:.5,end:1},Xk={start:"left",middle:"center",end:"right"};function Kk(t){if(!t)return;const e=nt(t)?{text:t}:t;if(!e.text||e.orient=="none")return;const n={"track-title":Yk,overlay:Qk}[e.style]??{},r={...Fy,...n,...e};let o={},i={x:0,y:0};const s=Zk[r.anchor??"middle"];switch(r.orient){case"top":i={x:s,y:1},o={baseline:"alphabetic",angle:0};break;case"right":i={x:1,y:1-s},o={baseline:"alphabetic",angle:90};break;case"bottom":i={x:s,y:0},o={baseline:"top",angle:0};break;case"left":i={x:0,y:s},o={baseline:"alphabetic",angle:-90};break}const a={...Fy,...o,...n,...e},c={xOffset:0,yOffset:0};switch(r.orient){case"top":c.yOffset=-a.offset;break;case"right":c.xOffset=a.offset;break;case"bottom":c.yOffset=a.offset;break;case"left":c.xOffset=-a.offset;break}return{configurableVisibility:!1,data:{values:[{}]},mark:{type:"text",tooltip:null,clip:!1,...i,...c,text:a.text,align:a.align??Xk[a.anchor],angle:a.angle,baseline:a.baseline,dx:a.dx,dy:a.dy,color:a.color,font:a.font,size:a.fontSize,fontStyle:a.fontStyle,fontWeight:a.fontWeight}}}class My extends tn{constructor(n,r){const o={scrollbarSize:8,scrollbarPadding:2};super({data:{values:[{}]},mark:{type:"rect",fill:"#b0b0b0",fillOpacity:.6,stroke:"white",strokeWidth:1,strokeOpacity:1,cornerRadius:5,clip:!1},configurableVisibility:!1},n.layoutParent.context,n.layoutParent,n.view,"scrollbar-"+r,{blockEncodingInheritance:!0});ge(this,Jo);ge(this,Ja,Hn.ZERO);ge(this,qr,0);ge(this,Mi,0);Ut(this,"viewportOffset",0);this.config=o,Te(this,Jo,r),this.interpolateViewportOffset=Wh(this.context.animator,i=>{this.viewportOffset=i.x},50,.4,{x:this.viewportOffset}),this.addInteractionEventListener("mousedown",(i,s)=>{if(s.stopPropagation(),W(this,qr)<=0)return;const a=h=>r=="vertical"?h.clientY:h.clientX,c=s.uiEvent;c.preventDefault();const l=this.scrollOffset,u=a(c),f=h=>{const p=lo(a(h)-u+l,0,W(this,qr));this.interpolateViewportOffset({x:p/W(this,qr)*W(this,Mi)})},d=()=>{document.removeEventListener("mousemove",f),document.removeEventListener("mouseup",d)};document.addEventListener("mouseup",d,!1),document.addEventListener("mousemove",f,!1)})}get scrollOffset(){return this.viewportOffset/W(this,Mi)*W(this,qr)}render(n,r,o){super.render(n,W(this,Ja),o)}updateScrollbar(n,r){const o=this.config.scrollbarPadding,i=this.config.scrollbarSize,s=W(this,Jo)=="horizontal"?"width":"height",a=Math.min(1,n[s]/r[s]),c=n[s]-2*o,l=a*c;Te(this,qr,c-l),Te(this,Mi,r[s]-n[s]),this.viewportOffset=lo(this.viewportOffset,0,W(this,Mi)),Te(this,Ja,W(this,Jo)=="vertical"?new Hn(()=>n.x+n.width-i-o,()=>n.y+o+this.scrollOffset,()=>i,()=>l):new Hn(()=>n.x+o+this.scrollOffset,()=>n.y+n.height-i-o,()=>l,()=>i))}}Jo=new WeakMap,Ja=new WeakMap,qr=new WeakMap,Mi=new WeakMap;class Jk extends mo{constructor(e,n,r={}){const o=n(),i=Object.keys(o.intervals);if(["x","y"].every(l=>!i.includes(l)))throw new Error("SelectionRect requires at least one of the channels 'x' or 'y' to be present in the selection.");const s={name:"selectionRect",configurableVisibility:!1,resolve:{scale:{x:"forced",y:"forced"}},data:{values:Py(n())},encoding:{},layer:[]};i.includes("x")&&(s.encoding.x={field:"_x",type:null,title:null},s.encoding.x2={field:"_x2"}),i.includes("y")&&(s.encoding.y={field:"_y",type:null,title:null},s.encoding.y2={field:"_y2"}),s.layer.push({name:"selectionRectRect",mark:{type:"rect",clip:!0,fill:"#808080",fillOpacity:.05,stroke:"black",strokeWidth:1,strokeOpacity:.2,...r}});const a=l=>{const u=e.view.getScaleResolution(l);return`format(datum._${l}2 - datum._${l}, '.3s')`+(u.type==="locus"?" + 'b'":"")},c=r.measure=="inside"?9:r.measure=="outside"?-9:0;i.includes("x")&&c!=0&&s.layer.push({name:"selectionRectTextX",mark:{type:"text",align:"center",paddingX:5,dy:c,tooltip:null},encoding:{text:{expr:a("x")},y:i.includes("y")?{field:"_y2",type:null,title:null}:{value:1},y2:null}}),i.includes("y")&&c!=0&&s.layer.push({name:"selectionRectTextY",mark:{type:"text",align:"center",paddingY:5,dy:c,tooltip:null,angle:-90},encoding:{text:{expr:a("y")},x2:null}}),super(s,e.layoutParent.context,e.layoutParent,e.view,"selectionRect",{blockEncodingInheritance:!0,contributesToScaleDomain:!1}),n.addListener(()=>{const l=n();this.context.dataFlow.findDataSourceByKey(this).updateDynamicData(Py(l))})}}function Py(t){const e=t.intervals.x,n=t.intervals.y;return!e&&!n?[]:[{_x:e==null?void 0:e[0],_x2:e==null?void 0:e[1],_y:n==null?void 0:n[0],_y2:n==null?void 0:n[1]}]}class Ly{constructor(e,n,r){ge(this,uu);if(this.layoutParent=n,this.view=e,this.serial=r,this.background=void 0,this.backgroundStroke=void 0,this.axes={},this.gridLines={},this.scrollbars={},this.selectionRect=void 0,this.title=void 0,this.coords=Hn.ZERO,e.needsAxes.x||e.needsAxes.y){const o=e.spec,i="view"in o?o==null?void 0:o.view:void 0,s=$k(i);s&&(this.background=new tn(s,n.context,n,e,"background"+r,{blockEncodingInheritance:!0}));const a=e_(i);a&&(this.backgroundStroke=new tn(a,n.context,n,e,"backgroundStroke"+r,{blockEncodingInheritance:!0}));const c=Kk(e.spec.title);if(c){const l=new tn(c,n.context,n,e,"title"+r,{blockEncodingInheritance:!0});this.title=l}}e.spec.viewportWidth!=null&&(this.scrollbars.horizontal=new My(this,"horizontal")),e.spec.viewportHeight!=null&&(this.scrollbars.vertical=new My(this,"vertical")),de(this,uu,wv).call(this)}*getChildren(){this.background&&(yield this.background),this.backgroundStroke&&(yield this.backgroundStroke),this.title&&(yield this.title),yield*Object.values(this.axes),yield*Object.values(this.gridLines),yield this.view,yield*Object.values(this.scrollbars),this.selectionRect&&(yield this.selectionRect)}async createAxes(){const{view:e,axes:n,gridLines:r}=this,o=(a,c)=>{const l=a.getAxisProps();if(l===null)return;const u=l?{...l}:{};if(!u.orient){for(const f of _l[c])if(!n[f]){u.orient=f;break}if(!u.orient)throw new Error("No slots available for an axis! Perhaps a LayerView has more than two children?")}if(u.title??(u.title=a.getTitle()),!_l[c].includes(u.orient))throw new Error(`Invalid axis orientation "${u.orient}" on channel "${c}"!`);return u},i=async(a,c,l)=>{const u=o(a,c);if(u){if(n[u.orient])throw new Error(`An axis with the orient "${u.orient}" already exists!`);const f=new Ty(u,a.scaleResolution.type,this.layoutParent.context,this.layoutParent,l);n[u.orient]=f,await f.initializeChildren()}},s=async(a,c,l)=>{const u=o(a,c);if(u&&(u.grid||u.chromGrid)){const f=new Gk(u,a.scaleResolution.type,this.layoutParent.context,this.layoutParent,l);r[u.orient]=f,await f.initializeChildren()}};for(const a of["x","y"])if(e.needsAxes[a]){const c=e.resolutions.axis[a];if(!c)continue;await i(c,a,e)}for(const a of["x","y"])if(e.needsAxes[a]&&e.getConfiguredOrDefaultResolution(a,"axis")!="excluded"){const c=e.getAxisResolution(a);if(!c)continue;await s(c,a,e)}if(e instanceof mo){for(const a of e)for(const[c,l]of Object.entries(a.resolutions.axis)){const u=l.getAxisProps();u&&u.orient&&await i(l,c,a)}for(const a of e)for(const[c,l]of Object.entries(a.resolutions.axis)){const u=l.getAxisProps();u&&!u.orient&&await i(l,c,a)}}[...Object.values(n),...Object.values(r)].forEach(a=>a.visit(c=>{c instanceof tn&&c.resolve("scale")}))}getOverhang(){const e=n=>{const r=this.axes[n];return r?Math.max(r.getPerpendicularSize()+(r.axisProps.offset??0),0):0};return new Ot(e("top"),e("right"),e("bottom"),e("left")).add(this.view.getOverhang())}getOverhangAndPadding(){return this.getOverhang().add(this.view.getPadding())}}uu=new WeakSet,wv=function(){const e=this.view,n=r=>{this.view.context.glHelper.canvas.style.cursor=r};for(const[r,o]of e.paramMediator.paramConfigs){if(!("select"in o))continue;const i=wl(o.select);if(!J1(i))continue;const s=i.encodings,a=Object.fromEntries(s.map(S=>{const E=this.view.getScaleResolution(S),I=E==null?void 0:E.scale;if(!I||!kt(I.type))throw new Error(`No continuous scale found for interval selection param "${r}" on channel "${S}"! Scale type is "${(I==null?void 0:I.type)??"none"}".`);return[S,E]}));if(this.selectionRect)throw new Error("Only one interval selection per container is currently allowed!");let c=!1,l=!1,u=!1,f=null;const d=(S,E)=>Object.fromEntries(s.map(I=>[I,[Math.min(S[I],E[I]),Math.max(S[I],E[I])]])),h=e.paramMediator.createExpression(r),p=e.paramMediator.getSetter(r);o.value&&p({type:"interval",intervals:o.value});const b=()=>{p(Q1(s)),n(null)};this.selectionRect=new Jk(this,h,i.mark),this.selectionRect.initializeChildren();const v=S=>{const E={x:0,y:0},I=e.coords.normalizePoint(S.x,S.y,!0);for(const _ of s){const B=a[_].scale,N=B.invert(_=="x"?I.x:I.y);E[_]=N+(["index","locus"].includes(B.type)?.5:0)}return E},y=S=>{var N,F,M,C;const{intervals:E}=S,I=(Y,Q,se)=>{const oe=(ye,he)=>he==null?null:a[ye].scale(he),ae=oe("x",Y)??se,ce=oe("y",Q)??se;return e.coords.denormalizePoint(ae,ce,!0)},_=I((N=E.x)==null?void 0:N[0],(F=E.y)==null?void 0:F[0],0),B=I((M=E.x)==null?void 0:M[1],(C=E.y)==null?void 0:C[1],1);return Hn.create(_.x,_.y,B.x-_.x,B.y-_.y)};e.addInteractionEventListener("mousedown",(S,E)=>{if(E.uiEvent.button!=0)return;if(f=c?y(h()):null,f)n("grabbing"),l=!0;else{const F=E.point;if($1(h())&&(l=!0),E.uiEvent.shiftKey)b(),u=!0;else if($1(h())){const C=(Y,Q)=>{e.removeInteractionEventListener("mouseup",C);const se=Q.point;F.subtract(se).length<2&&b()};e.addInteractionEventListener("mouseup",C);return}else return}E.stopPropagation();const I=E.point,_=Kt.fromMouseEvent(E.uiEvent).subtract(I),B=F=>{const M=Kt.fromMouseEvent(F).subtract(_);let C;if(f){const Y=M.subtract(I),Q=f.translate(Y.x,Y.y);C=d(v(new Kt(Q.x,Q.y)),v(new Kt(Q.x2,Q.y2)))}else C=d(v(I),v(M));for(const Y of s){const Q=a[Y],{zoomExtent:se,scale:oe}=Q,ae=C[Y];if(["index","locus"].includes(oe.type)&&(ae[0]=Math.ceil(ae[0]),ae[1]=Math.ceil(ae[1])),f){const ce=ae[1]-ae[0],ye=se[0],he=se[1];ae[0]<ye&&(ae[0]=ye,ae[1]=ye+ce),ae[1]>he&&(ae[1]=he,ae[0]=he-ce)}else ae[0]=Math.max(se[0],ae[0]),ae[1]=Math.min(se[1],ae[1]);ae[1]=Math.min(se[1],ae[1])}p({type:"interval",intervals:C})},N=()=>{document.removeEventListener("mousemove",B),document.removeEventListener("mouseup",N),u=!1,f&&(n("move"),f=null)};document.addEventListener("mousemove",B),document.addEventListener("mouseup",N)}),e.addInteractionEventListener("click",(S,E)=>{E.uiEvent.button==0&&l&&(E.stopPropagation(),l=!1)},!0);const A=S=>CI(h(),v(S));e.addInteractionEventListener("dblclick",(S,E)=>{A(E.point)&&(b(),E.stopPropagation())},!0),e.addInteractionEventListener("mousemove",(S,E)=>{A(E.point)?u||(c=!0,f||n("move")):(c=!1,f||n(null))})}};function $k(t){if(t!=null&&t.fill||t!=null&&t.fillOpacity||t!=null&&t.shadowOpacity)return{configurableVisibility:!1,data:{values:[{}]},mark:{color:t.fill,opacity:t.fillOpacity??(t.fill?1:0),type:"rect",clip:!1,tooltip:null,minHeight:1,minOpacity:0,shadowBlur:t.shadowBlur,shadowColor:t.shadowColor,shadowOffsetX:t.shadowOffsetX,shadowOffsetY:t.shadowOffsetY,shadowOpacity:t.shadowOpacity}}}function e_(t){if(!(!t||!t.stroke||t.strokeWidth===0||t.strokeOpacity===0))return{configurableVisibility:!1,resolve:{scale:{x:"excluded",y:"excluded"},axis:{x:"excluded",y:"excluded"}},data:{values:[{x:0,y:0,x2:1,y2:0},{x:1,y:0,x2:1,y2:1},{x:1,y:1,x2:0,y2:1},{x:0,y:1,x2:0,y2:0}]},mark:{size:t.strokeWidth??1,color:t.stroke??"lightgray",strokeCap:"square",opacity:t.strokeOpacity??1,type:"rule",clip:!1,tooltip:null},encoding:{x:{field:"x",type:"quantitative",scale:null},y:{field:"y",type:"quantitative",scale:null},x2:{field:"x2"},y2:{field:"y2"}}}}class t_ extends xa{constructor(n,r,o,i,s,a,c){super(n,r,o,i,s,c);ge(this,He);ge(this,$o,1/0);ge(this,es,10);ge(this,rn,[]);ge(this,Pi,{});ge(this,ts,0);this.spec=n,Te(this,es,n.spacing??10),Te(this,$o,a),Te(this,rn,[]),this.wrappingFacet=!1}appendChild(n){n.layoutParent??(n.layoutParent=this),W(this,rn).push(new Ly(n,this,W(this,ts))),cv(this,ts)._++}setChildren(n){Te(this,rn,[]);for(const r of n)this.appendChild(r)}replaceChild(n,r){const o=W(this,rn).findIndex(i=>i.view==n);if(o>=0)W(this,rn)[o]=new Ly(r,this,W(this,ts));else throw new Error("Not my child view!")}get children(){return W(this,rn).map(n=>n.view)}get childCount(){return W(this,rn).length}async createAxes(){const n=[];for(const r of uo){const o=this.resolutions.axis[r];if(o){const i=o.getAxisProps();if(i){const s={title:o.getTitle(),orient:_l[r][0],...i},a=new Ty(s,o.scaleResolution.type,this.context,this,this);n.push(a.initializeChildren()),W(this,Pi)[r]=a}}}return Promise.all([...n,...W(this,rn).map(r=>r.createAxes())])}*[Symbol.iterator](){for(const n of W(this,rn))yield*n.getChildren();for(const n of Object.values(W(this,Pi)))yield n}getOverhang(){return de(this,He,vv).call(this).union(de(this,He,du).call(this))}getSize(){return this._cache("size",()=>new Mr(de(this,He,_0).call(this,"column"),de(this,He,_0).call(this,"row")).addPadding(de(this,He,du).call(this)))}render(n,r,o={}){if(super.render(n,r,o),!this.isConfiguredVisible())return;this.layoutParent||(r=r.shrink(this.getPadding())),r=r.shrink(de(this,He,du).call(this)),n.pushView(this,r);const i={devicePixelRatio:this.context.devicePixelRatio},s=$b(de(this,He,k0).call(this,"column"),r.width,i),a=$b(de(this,He,k0).call(this,"row"),r.height,i),c=new Iy(W(this,He,Oi).length,W(this,$o)??1/0),l=u=>Math.round(u*devicePixelRatio)/devicePixelRatio;for(const[u,f]of 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this._cache(`size/directionSizes/${n}`,()=>W(this,He,xv)[n=="column"?"colIndices":"rowIndices"].map(i=>({axisBefore:o(i,0),axisAfter:o(i,1),view:zD(i.map(s=>W(this,He,Oi)[s].view.getViewportSize()[r]))})))},k0=function(n){const r=de(this,He,nc).call(this,n),o=[];o.push(ma);for(const[i,s]of r.entries())i>0&&o.push({px:W(this,es),grow:0}),(i==0||this.wrappingFacet)&&o.push(ma),o.push({px:s.axisBefore,grow:0}),o.push(s.view),o.push({px:s.axisAfter,grow:0}),(i==r.length-1||this.wrappingFacet)&&o.push(ma);return o},_0=function(n){let r=0,o=0;const i=n=="row"?this.spec.height:this.spec.width;if(i||i===0)return ty(i);const s=de(this,He,nc).call(this,n);for(const[a,c]of s.entries())a>0&&(o+=W(this,es)),(a==0||this.wrappingFacet)&&(o+=0),o+=c.axisBefore,o+=c.view.px??0,r+=c.view.grow??0,o+=c.axisAfter,(a==s.length-1||this.wrappingFacet)&&(o+=0);return{px:o,grow:r}},R0=function(n,r){return n=="row"&&this.wrappingFacet?1+6*r+2:2+4*r+1},vv=function(){const n=de(this,He,nc).call(this,"column"),r=de(this,He,nc).call(this,"row");return!n.length||!r.length?Ot.zero():new Ot(r.at(0).axisBefore,n.at(-1).axisAfter,r.at(-1).axisAfter,n.at(0).axisBefore)},du=function(){const n=r=>{const o=Qh[r],i=W(this,Pi)[o];return(i==null?void 0:i.axisProps.orient)!==r?0:Math.max(i.getPerpendicularSize()+(i.axisProps.offset??0),0)};return new Ot(n("top"),n("right"),n("bottom"),n("left"))},Av=function(n,r,o){for(const[i,s]of Object.entries(n_(r))){if(s.size<=0)continue;const a=n.normalizePoint(o.x,o.y),c=n.normalizePoint(o.x+o.xDelta,o.y+o.yDelta),l={x:c.x-a.x,y:c.y-a.y};for(const u of s)u.zoom(2**o.zDelta,i=="y"?1-a[i]:a[i],i=="x"?l.x:-l.y)}this.context.animator.requestRender()};function n_(t){const e={x:new Set,y:new Set};return t.visit(n=>{for(const[r,o]of Object.entries(e)){const i=n.getScaleResolution(r);i&&i.isZoomable()&&o.add(i)}}),e}function r_(t){let e=!0;return t.visit(n=>{n instanceof tn&&e&&(e=n.mark.properties.clip===!0)}),e}function Oy(t,e,n){const r=n.axisProps,o=n.getPerpendicularSize();if(e=="bottom")return t.translate(0,t.height+r.offset).modify({height:o});if(e=="top")return t.translate(0,-o-r.offset).modify({height:o});if(e=="left")return t.translate(-o-r.offset,0).modify({width:o});if(e=="right")return t.translate(t.width+r.offset,0).modify({width:o})}class Xh extends t_{constructor(e,n,r,o,i){super(e,n,r,o,i,$h(e)?e.columns:Rl(e)?1:1/0),this.spec=e}async initializeChildren(){const e=this.spec,n=$h(e)?e.concat:Rl(e)?e.vconcat:e.hconcat;this.setChildren(await Promise.all(n.map((r,o)=>this.context.createOrImportView(r,this,this,"grid"+o)))),await this.createAxes()}getDefaultResolution(e,n){return n=="axis"?"independent":Rl(this.spec)&&e==="x"||Uy(this.spec)&&e==="y"?"shared":"independent"}}const Ny="viewRoot";class i_{constructor(e={}){ge(this,ns,new Map);this.options={allowImport:!0,wrapRoot:!0,...e};const n=r=>(o,i,s,a,c)=>new r(o,i,s,a,o.name??c);this.addViewType(Jh,n(mo)),this.addViewType(Kh,n(tn)),this.addViewType(Rl,n(Xh)),this.addViewType(Uy,n(Xh)),this.addViewType($h,n(Xh)),this.addViewType(a_,()=>{throw new Error("SampleView is not supported by the @genome-spy/core package. 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Cannot create a view!");return n.length==1}async createOrImportView(e,n,r,o,i,s){let a;if(s_(e)){let u;if("url"in e.import)if(this.options.allowImport)u=await lk(e,o.getBaseUrl(),n);else throw new Fr("Importing views is not allowed!",r);else if("template"in e.import)u=zy(e.import.template,o);else throw new Error("Invalid import: "+JSON.stringify(e));s==null||s(u),o_(u,e),a=u}else a=e;const c=u=>{var f;return(f=u==null?void 0:u.params)==null?void 0:f.some(d=>tb(d)&&wl(d.select).type=="interval")};!o&&this.options.wrapRoot&&(Kh(a)||Jh(a)||c(a))&&i===Ny&&(a={name:"implicitRoot",vconcat:[a]});const l=this.createView(a,n,r,o,i);return l instanceof xa&&await l.initializeChildren(),l}}ns=new WeakMap;function zy(t,e){var r,o;const n=(o=(r=e.spec)==null?void 0:r.templates)==null?void 0:o[t];if(n)return structuredClone(n);if(e.dataParent)return zy(t,e.dataParent);throw new Error(`Cannot find template "${t}" in current view or its ancestors!`)}function o_(t,e){e.name!=null&&(t.name=e.name);const n=Dt(e.params)?e.params:Ft(e.params)?Object.entries(e.params).map(([r,o])=>({name:r,value:o})):[];if(n.length){t.params??(t.params=[]);for(const r of n){const o=t.params.findIndex(i=>i.name==r.name);o>=0&&(t.params[o]=r)}for(const r of n)t.params.some(o=>o.name==r.name)||t.params.push(r)}}function Kh(t){return"mark"in t&&(nt(t.mark)||Ft(t.mark))}function Jh(t){return"layer"in t&&Ft(t.layer)}function s_(t){return"import"in t}function Rl(t){return"vconcat"in t&&Dt(t.vconcat)}function Uy(t){return"hconcat"in t&&Dt(t.hconcat)}function $h(t){return"concat"in t&&Dt(t.concat)}function a_(t){return"samples"in t&&Ft(t.samples)&&"spec"in t&&Ft(t.spec)}function c_(t){const e=Math.floor(Math.random()*16777215).toString(16),n=[];for(const r of t.paramConfigs.values()){if(!kI(r))continue;const o=r.bind;if(!o||!("input"in o))continue;const i=r.name,s=t.getSetter(i),a=t.getValue(i),c=o.name??i,l=o.debounce?Bl(s,o.debounce,!1):s,u=`${e}-param-${i}`;if(o.input=="range")n.push(ot`<label for=${u}>${c}</label>
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@@ -647,12 +647,12 @@ chrM 16299`};function SD(t){if(!(t in Gb))throw new Error(`Unknown assembly: ${t
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*/var jy;function Aa(){return jy||(jy=1,function(t){const e=g_(),n=m_(),r=typeof Symbol=="function"&&typeof Symbol.for=="function"?Symbol.for("nodejs.util.inspect.custom"):null;t.Buffer=a,t.SlowBuffer=A,t.INSPECT_MAX_BYTES=50;const o=2147483647;t.kMaxLength=o,a.TYPED_ARRAY_SUPPORT=i(),!a.TYPED_ARRAY_SUPPORT&&typeof console<"u"&&typeof console.error=="function"&&console.error("This browser lacks typed array (Uint8Array) support which is required by `buffer` v5.x. 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g.insert=0,K===c?(Ae(g,!0),g.strm.avail_out===0?fe:L):(g.strstart>g.block_start&&(Ae(g,!1),g.strm.avail_out===0),ee)}function Nt(g,K){for(var $,R;;){if(g.lookahead<he){if($e(g),g.lookahead<he&&K===i)return ee;if(g.lookahead===0)break}if($=0,g.lookahead>=ce&&(g.ins_h=(g.ins_h<<g.hash_shift^g.window[g.strstart+ce-1])&g.hash_mask,$=g.prev[g.strstart&g.w_mask]=g.head[g.ins_h],g.head[g.ins_h]=g.strstart),$!==0&&g.strstart-$<=g.w_size-he&&(g.match_length=It(g,$)),g.match_length>=ce)if(R=e._tr_tally(g,g.strstart-g.match_start,g.match_length-ce),g.lookahead-=g.match_length,g.match_length<=g.max_lazy_match&&g.lookahead>=ce){g.match_length--;do g.strstart++,g.ins_h=(g.ins_h<<g.hash_shift^g.window[g.strstart+ce-1])&g.hash_mask,$=g.prev[g.strstart&g.w_mask]=g.head[g.ins_h],g.head[g.ins_h]=g.strstart;while(--g.match_length!==0);g.strstart++}else g.strstart+=g.match_length,g.match_length=0,g.ins_h=g.window[g.strstart],g.ins_h=(g.ins_h<<g.hash_shift^g.window[g.strstart+1])&g.hash_mask;else 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ee;if(g.lookahead===0)break}if($=0,g.lookahead>=ce&&(g.ins_h=(g.ins_h<<g.hash_shift^g.window[g.strstart+ce-1])&g.hash_mask,$=g.prev[g.strstart&g.w_mask]=g.head[g.ins_h],g.head[g.ins_h]=g.strstart),g.prev_length=g.match_length,g.prev_match=g.match_start,g.match_length=ce-1,$!==0&&g.prev_length<g.max_lazy_match&&g.strstart-$<=g.w_size-he&&(g.match_length=It(g,$),g.match_length<=5&&(g.strategy===v||g.match_length===ce&&g.strstart-g.match_start>4096)&&(g.match_length=ce-1)),g.prev_length>=ce&&g.match_length<=g.prev_length){H=g.strstart+g.lookahead-ce,R=e._tr_tally(g,g.strstart-1-g.prev_match,g.prev_length-ce),g.lookahead-=g.prev_length-1,g.prev_length-=2;do++g.strstart<=H&&(g.ins_h=(g.ins_h<<g.hash_shift^g.window[g.strstart+ce-1])&g.hash_mask,$=g.prev[g.strstart&g.w_mask]=g.head[g.ins_h],g.head[g.ins_h]=g.strstart);while(--g.prev_length!==0);if(g.match_available=0,g.match_length=ce-1,g.strstart++,R&&(Ae(g,!1),g.strm.avail_out===0))return ee}else 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g.insert=0,K===c?(Ae(g,!0),g.strm.avail_out===0?fe:L):g.last_lit&&(Ae(g,!1),g.strm.avail_out===0)?ee:J}function m(g,K,$,R,H){this.good_length=g,this.max_lazy=K,this.nice_length=$,this.max_chain=R,this.func=H}var w;w=[new m(0,0,0,0,Rt),new m(4,4,8,4,Nt),new m(4,5,16,8,Nt),new m(4,6,32,32,Nt),new m(4,4,16,16,et),new m(8,16,32,32,et),new m(8,16,128,128,et),new m(8,32,128,256,et),new m(32,128,258,1024,et),new m(32,258,258,4096,et)];function O(g){g.window_size=2*g.w_size,Be(g.head),g.max_lazy_match=w[g.level].max_lazy,g.good_match=w[g.level].good_length,g.nice_match=w[g.level].nice_length,g.max_chain_length=w[g.level].max_chain,g.strstart=0,g.block_start=0,g.lookahead=0,g.insert=0,g.match_length=g.prev_length=ce-1,g.match_available=0,g.ins_h=0}function 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t.Buf16(2*Y+1),Be(this.depth),this.l_buf=0,this.lit_bufsize=0,this.last_lit=0,this.d_buf=0,this.opt_len=0,this.static_len=0,this.matches=0,this.insert=0,this.bi_buf=0,this.bi_valid=0}function z(g){var K;return!g||!g.state?te(g,d):(g.total_in=g.total_out=0,g.data_type=I,K=g.state,K.pending=0,K.pending_out=0,K.wrap<0&&(K.wrap=-K.wrap),K.status=K.wrap?we:q,g.adler=K.wrap===2?0:1,K.last_flush=i,e._tr_init(K),u)}function V(g){var K=z(g);return K===u&&O(g.state),K}function ue(g,K){return!g||!g.state||g.state.wrap!==2?d:(g.state.gzhead=K,u)}function G(g,K,$,R,H,Z){if(!g)return d;var Ce=1;if(K===b&&(K=6),R<0?(Ce=0,R=-R):R>15&&(Ce=2,R-=16),H<1||H>B||$!==_||R<8||R>15||K<0||K>9||Z<0||Z>S)return te(g,d);R===8&&(R=9);var me=new x;return g.state=me,me.strm=g,me.wrap=Ce,me.gzhead=null,me.w_bits=R,me.w_size=1<<me.w_bits,me.w_mask=me.w_size-1,me.hash_bits=H+7,me.hash_size=1<<me.hash_bits,me.hash_mask=me.hash_size-1,me.hash_shift=~~((me.hash_bits+ce-1)/ce),me.window=new t.Buf8(me.w_size*2),me.head=new t.Buf16(me.hash_size),me.prev=new t.Buf16(me.w_size),me.lit_bufsize=1<<H+6,me.pending_buf_size=me.lit_bufsize*4,me.pending_buf=new t.Buf8(me.pending_buf_size),me.d_buf=1*me.lit_bufsize,me.l_buf=3*me.lit_bufsize,me.level=K,me.strategy=Z,me.method=$,V(g)}function X(g,K){return G(g,K,_,N,M,E)}function T(g,K){var $,R,H,Z;if(!g||!g.state||K>l||K<0)return g?te(g,d):d;if(R=g.state,!g.output||!g.input&&g.avail_in!==0||R.status===j&&K!==c)return te(g,g.avail_out===0?p:d);if(R.strm=g,$=R.last_flush,R.last_flush=K,R.status===we)if(R.wrap===2)g.adler=0,Re(R,31),Re(R,139),Re(R,8),R.gzhead?(Re(R,(R.gzhead.text?1:0)+(R.gzhead.hcrc?2:0)+(R.gzhead.extra?4:0)+(R.gzhead.name?8:0)+(R.gzhead.comment?16:0)),Re(R,R.gzhead.time&255),Re(R,R.gzhead.time>>8&255),Re(R,R.gzhead.time>>16&255),Re(R,R.gzhead.time>>24&255),Re(R,R.level===9?2:R.strategy>=y||R.level<2?4:0),Re(R,R.gzhead.os&255),R.gzhead.extra&&R.gzhead.extra.length&&(Re(R,R.gzhead.extra.length&255),Re(R,R.gzhead.extra.length>>8&255)),R.gzhead.hcrc&&(g.adler=r(g.adler,R.pending_buf,R.pending,0)),R.gzindex=0,R.status=Ee):(Re(R,0),Re(R,0),Re(R,0),Re(R,0),Re(R,0),Re(R,R.level===9?2:R.strategy>=y||R.level<2?4:0),Re(R,D),R.status=q);else{var Ce=_+(R.w_bits-8<<4)<<8,me=-1;R.strategy>=y||R.level<2?me=0:R.level<6?me=1:R.level===6?me=2:me=3,Ce|=me<<6,R.strstart!==0&&(Ce|=De),Ce+=31-Ce%31,R.status=q,dt(R,Ce),R.strstart!==0&&(dt(R,g.adler>>>16),dt(R,g.adler&65535)),g.adler=1}if(R.status===Ee)if(R.gzhead.extra){for(H=R.pending;R.gzindex<(R.gzhead.extra.length&65535)&&!(R.pending===R.pending_buf_size&&(R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),ve(g),H=R.pending,R.pending===R.pending_buf_size));)Re(R,R.gzhead.extra[R.gzindex]&255),R.gzindex++;R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),R.gzindex===R.gzhead.extra.length&&(R.gzindex=0,R.status=Ie)}else R.status=Ie;if(R.status===Ie)if(R.gzhead.name){H=R.pending;do{if(R.pending===R.pending_buf_size&&(R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),ve(g),H=R.pending,R.pending===R.pending_buf_size)){Z=1;break}R.gzindex<R.gzhead.name.length?Z=R.gzhead.name.charCodeAt(R.gzindex++)&255:Z=0,Re(R,Z)}while(Z!==0);R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),Z===0&&(R.gzindex=0,R.status=Ge)}else R.status=Ge;if(R.status===Ge)if(R.gzhead.comment){H=R.pending;do{if(R.pending===R.pending_buf_size&&(R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),ve(g),H=R.pending,R.pending===R.pending_buf_size)){Z=1;break}R.gzindex<R.gzhead.comment.length?Z=R.gzhead.comment.charCodeAt(R.gzindex++)&255:Z=0,Re(R,Z)}while(Z!==0);R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),Z===0&&(R.status=Ve)}else R.status=Ve;if(R.status===Ve&&(R.gzhead.hcrc?(R.pending+2>R.pending_buf_size&&ve(g),R.pending+2<=R.pending_buf_size&&(Re(R,g.adler&255),Re(R,g.adler>>8&255),g.adler=0,R.status=q)):R.status=q),R.pending!==0){if(ve(g),g.avail_out===0)return R.last_flush=-1,u}else if(g.avail_in===0&&le(K)<=le($)&&K!==c)return te(g,p);if(R.status===j&&g.avail_in!==0)return te(g,p);if(g.avail_in!==0||R.lookahead!==0||K!==i&&R.status!==j){var xe=R.strategy===y?k(R,K):R.strategy===A?zt(R,K):w[R.level].func(R,K);if((xe===fe||xe===L)&&(R.status=j),xe===ee||xe===fe)return g.avail_out===0&&(R.last_flush=-1),u;if(xe===J&&(K===s?e._tr_align(R):K!==l&&(e._tr_stored_block(R,0,0,!1),K===a&&(Be(R.head),R.lookahead===0&&(R.strstart=0,R.block_start=0,R.insert=0))),ve(g),g.avail_out===0))return R.last_flush=-1,u}return K!==c?u:R.wrap<=0?f:(R.wrap===2?(Re(R,g.adler&255),Re(R,g.adler>>8&255),Re(R,g.adler>>16&255),Re(R,g.adler>>24&255),Re(R,g.total_in&255),Re(R,g.total_in>>8&255),Re(R,g.total_in>>16&255),Re(R,g.total_in>>24&255)):(dt(R,g.adler>>>16),dt(R,g.adler&65535)),ve(g),R.wrap>0&&(R.wrap=-R.wrap),R.pending!==0?u:f)}function re(g){var K;return!g||!g.state?d:(K=g.state.status,K!==we&&K!==Ee&&K!==Ie&&K!==Ge&&K!==Ve&&K!==q&&K!==j?te(g,d):(g.state=null,K===q?te(g,h):u))}function _e(g,K){var $=K.length,R,H,Z,Ce,me,xe,Ue,bn;if(!g||!g.state||(R=g.state,Ce=R.wrap,Ce===2||Ce===1&&R.status!==we||R.lookahead))return d;for(Ce===1&&(g.adler=n(g.adler,K,$,0)),R.wrap=0,$>=R.w_size&&(Ce===0&&(Be(R.head),R.strstart=0,R.block_start=0,R.insert=0),bn=new t.Buf8(R.w_size),t.arraySet(bn,K,$-R.w_size,R.w_size,0),K=bn,$=R.w_size),me=g.avail_in,xe=g.next_in,Ue=g.input,g.avail_in=$,g.next_in=0,g.input=K,$e(R);R.lookahead>=ce;){H=R.strstart,Z=R.lookahead-(ce-1);do R.ins_h=(R.ins_h<<R.hash_shift^R.window[H+ce-1])&R.hash_mask,R.prev[H&R.w_mask]=R.head[R.ins_h],R.head[R.ins_h]=H,H++;while(--Z);R.strstart=H,R.lookahead=ce-1,$e(R)}return R.strstart+=R.lookahead,R.block_start=R.strstart,R.insert=R.lookahead,R.lookahead=0,R.match_length=R.prev_length=ce-1,R.match_available=0,g.next_in=xe,g.input=Ue,g.avail_in=me,R.wrap=Ce,u}return In.deflateInit=X,In.deflateInit2=G,In.deflateReset=V,In.deflateResetKeep=z,In.deflateSetHeader=ue,In.deflate=T,In.deflateEnd=re,In.deflateSetDictionary=_e,In.deflateInfo="pako deflate (from Nodeca project)",In}var Ai={},r2;function i2(){if(r2)return Ai;r2=1;var t=Lr(),e=!0,n=!0;try{String.fromCharCode.apply(null,[0])}catch{e=!1}try{String.fromCharCode.apply(null,new Uint8Array(1))}catch{n=!1}for(var r=new t.Buf8(256),o=0;o<256;o++)r[o]=o>=252?6:o>=248?5:o>=240?4:o>=224?3:o>=192?2:1;r[254]=r[254]=1,Ai.string2buf=function(s){var a,c,l,u,f,d=s.length,h=0;for(u=0;u<d;u++)c=s.charCodeAt(u),(c&64512)===55296&&u+1<d&&(l=s.charCodeAt(u+1),(l&64512)===56320&&(c=65536+(c-55296<<10)+(l-56320),u++)),h+=c<128?1:c<2048?2:c<65536?3:4;for(a=new t.Buf8(h),f=0,u=0;f<h;u++)c=s.charCodeAt(u),(c&64512)===55296&&u+1<d&&(l=s.charCodeAt(u+1),(l&64512)===56320&&(c=65536+(c-55296<<10)+(l-56320),u++)),c<128?a[f++]=c:c<2048?(a[f++]=192|c>>>6,a[f++]=128|c&63):c<65536?(a[f++]=224|c>>>12,a[f++]=128|c>>>6&63,a[f++]=128|c&63):(a[f++]=240|c>>>18,a[f++]=128|c>>>12&63,a[f++]=128|c>>>6&63,a[f++]=128|c&63);return a};function i(s,a){if(a<65534&&(s.subarray&&n||!s.subarray&&e))return String.fromCharCode.apply(null,t.shrinkBuf(s,a));for(var c="",l=0;l<a;l++)c+=String.fromCharCode(s[l]);return c}return Ai.buf2binstring=function(s){return i(s,s.length)},Ai.binstring2buf=function(s){for(var a=new t.Buf8(s.length),c=0,l=a.length;c<l;c++)a[c]=s.charCodeAt(c);return a},Ai.buf2string=function(s,a){var c,l,u,f,d=a||s.length,h=new Array(d*2);for(l=0,c=0;c<d;){if(u=s[c++],u<128){h[l++]=u;continue}if(f=r[u],f>4){h[l++]=65533,c+=f-1;continue}for(u&=f===2?31:f===3?15:7;f>1&&c<d;)u=u<<6|s[c++]&63,f--;if(f>1){h[l++]=65533;continue}u<65536?h[l++]=u:(u-=65536,h[l++]=55296|u>>10&1023,h[l++]=56320|u&1023)}return i(h,l)},Ai.utf8border=function(s,a){var c;for(a=a||s.length,a>s.length&&(a=s.length),c=a-1;c>=0&&(s[c]&192)===128;)c--;return c<0||c===0?a:c+r[s[c]]>a?c:a},Ai}var sd,o2;function s2(){if(o2)return sd;o2=1;function t(){this.input=null,this.next_in=0,this.avail_in=0,this.total_in=0,this.output=null,this.next_out=0,this.avail_out=0,this.total_out=0,this.msg="",this.state=null,this.data_type=2,this.adler=0}return sd=t,sd}var a2;function S_(){if(a2)return bo;a2=1;var t=E_(),e=Lr(),n=i2(),r=od(),o=s2(),i=Object.prototype.toString,s=0,a=4,c=0,l=1,u=2,f=-1,d=0,h=8;function p(A){if(!(this instanceof p))return new p(A);this.options=e.assign({level:f,method:h,chunkSize:16384,windowBits:15,memLevel:8,strategy:d,to:""},A||{});var S=this.options;S.raw&&S.windowBits>0?S.windowBits=-S.windowBits:S.gzip&&S.windowBits>0&&S.windowBits<16&&(S.windowBits+=16),this.err=0,this.msg="",this.ended=!1,this.chunks=[],this.strm=new o,this.strm.avail_out=0;var E=t.deflateInit2(this.strm,S.level,S.method,S.windowBits,S.memLevel,S.strategy);if(E!==c)throw new Error(r[E]);if(S.header&&t.deflateSetHeader(this.strm,S.header),S.dictionary){var I;if(typeof S.dictionary=="string"?I=n.string2buf(S.dictionary):i.call(S.dictionary)==="[object ArrayBuffer]"?I=new Uint8Array(S.dictionary):I=S.dictionary,E=t.deflateSetDictionary(this.strm,I),E!==c)throw new Error(r[E]);this._dict_set=!0}}p.prototype.push=function(A,S){var E=this.strm,I=this.options.chunkSize,_,B;if(this.ended)return!1;B=S===~~S?S:S===!0?a:s,typeof A=="string"?E.input=n.string2buf(A):i.call(A)==="[object ArrayBuffer]"?E.input=new Uint8Array(A):E.input=A,E.next_in=0,E.avail_in=E.input.length;do{if(E.avail_out===0&&(E.output=new e.Buf8(I),E.next_out=0,E.avail_out=I),_=t.deflate(E,B),_!==l&&_!==c)return this.onEnd(_),this.ended=!0,!1;(E.avail_out===0||E.avail_in===0&&(B===a||B===u))&&(this.options.to==="string"?this.onData(n.buf2binstring(e.shrinkBuf(E.output,E.next_out))):this.onData(e.shrinkBuf(E.output,E.next_out)))}while((E.avail_in>0||E.avail_out===0)&&_!==l);return B===a?(_=t.deflateEnd(this.strm),this.onEnd(_),this.ended=!0,_===c):(B===u&&(this.onEnd(c),E.avail_out=0),!0)},p.prototype.onData=function(A){this.chunks.push(A)},p.prototype.onEnd=function(A){A===c&&(this.options.to==="string"?this.result=this.chunks.join(""):this.result=e.flattenChunks(this.chunks)),this.chunks=[],this.err=A,this.msg=this.strm.msg};function b(A,S){var E=new p(S);if(E.push(A,!0),E.err)throw E.msg||r[E.err];return E.result}function v(A,S){return S=S||{},S.raw=!0,b(A,S)}function y(A,S){return S=S||{},S.gzip=!0,b(A,S)}return bo.Deflate=p,bo.deflate=b,bo.deflateRaw=v,bo.gzip=y,bo}var yo={},hn={},ad,c2;function C_(){if(c2)return ad;c2=1;var t=30,e=12;return ad=function(r,o){var i,s,a,c,l,u,f,d,h,p,b,v,y,A,S,E,I,_,B,N,M,F,C,Y,Q;i=r.state,s=r.next_in,Y=r.input,a=s+(r.avail_in-5),c=r.next_out,Q=r.output,l=c-(o-r.avail_out),u=c+(r.avail_out-257),f=i.dmax,d=i.wsize,h=i.whave,p=i.wnext,b=i.window,v=i.hold,y=i.bits,A=i.lencode,S=i.distcode,E=(1<<i.lenbits)-1,I=(1<<i.distbits)-1;e:do{y<15&&(v+=Y[s++]<<y,y+=8,v+=Y[s++]<<y,y+=8),_=A[v&E];t:for(;;){if(B=_>>>24,v>>>=B,y-=B,B=_>>>16&255,B===0)Q[c++]=_&65535;else if(B&16){N=_&65535,B&=15,B&&(y<B&&(v+=Y[s++]<<y,y+=8),N+=v&(1<<B)-1,v>>>=B,y-=B),y<15&&(v+=Y[s++]<<y,y+=8,v+=Y[s++]<<y,y+=8),_=S[v&I];n:for(;;){if(B=_>>>24,v>>>=B,y-=B,B=_>>>16&255,B&16){if(M=_&65535,B&=15,y<B&&(v+=Y[s++]<<y,y+=8,y<B&&(v+=Y[s++]<<y,y+=8)),M+=v&(1<<B)-1,M>f){r.msg="invalid distance too far back",i.mode=t;break e}if(v>>>=B,y-=B,B=c-l,M>B){if(B=M-B,B>h&&i.sane){r.msg="invalid distance too far 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t=Lr(),e=15,n=852,r=592,o=0,i=1,s=2,a=[3,4,5,6,7,8,9,10,11,13,15,17,19,23,27,31,35,43,51,59,67,83,99,115,131,163,195,227,258,0,0],c=[16,16,16,16,16,16,16,16,17,17,17,17,18,18,18,18,19,19,19,19,20,20,20,20,21,21,21,21,16,72,78],l=[1,2,3,4,5,7,9,13,17,25,33,49,65,97,129,193,257,385,513,769,1025,1537,2049,3073,4097,6145,8193,12289,16385,24577,0,0],u=[16,16,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,29,29,64,64];return cd=function(d,h,p,b,v,y,A,S){var E=S.bits,I=0,_=0,B=0,N=0,M=0,F=0,C=0,Y=0,Q=0,se=0,oe,ae,ce,ye,he,De=null,we=0,Ee,Ie=new t.Buf16(e+1),Ge=new t.Buf16(e+1),Ve=null,q=0,j,ee,J;for(I=0;I<=e;I++)Ie[I]=0;for(_=0;_<b;_++)Ie[h[p+_]]++;for(M=E,N=e;N>=1&&Ie[N]===0;N--);if(M>N&&(M=N),N===0)return v[y++]=1<<24|64<<16|0,v[y++]=1<<24|64<<16|0,S.bits=1,0;for(B=1;B<N&&Ie[B]===0;B++);for(M<B&&(M=B),Y=1,I=1;I<=e;I++)if(Y<<=1,Y-=Ie[I],Y<0)return-1;if(Y>0&&(d===o||N!==1))return-1;for(Ge[1]=0,I=1;I<e;I++)Ge[I+1]=Ge[I]+Ie[I];for(_=0;_<b;_++)h[p+_]!==0&&(A[Ge[h[p+_]]++]=_);if(d===o?(De=Ve=A,Ee=19):d===i?(De=a,we-=257,Ve=c,q-=257,Ee=256):(De=l,Ve=u,Ee=-1),se=0,_=0,I=B,he=y,F=M,C=0,ce=-1,Q=1<<M,ye=Q-1,d===i&&Q>n||d===s&&Q>r)return 1;for(;;){j=I-C,A[_]<Ee?(ee=0,J=A[_]):A[_]>Ee?(ee=Ve[q+A[_]],J=De[we+A[_]]):(ee=96,J=0),oe=1<<I-C,ae=1<<F,B=ae;do ae-=oe,v[he+(se>>C)+ae]=j<<24|ee<<16|J|0;while(ae!==0);for(oe=1<<I-1;se&oe;)oe>>=1;if(oe!==0?(se&=oe-1,se+=oe):se=0,_++,--Ie[I]===0){if(I===N)break;I=h[p+A[_]]}if(I>M&&(se&ye)!==ce){for(C===0&&(C=M),he+=B,F=I-C,Y=1<<F;F+C<N&&(Y-=Ie[F+C],!(Y<=0));)F++,Y<<=1;if(Q+=1<<F,d===i&&Q>n||d===s&&Q>r)return 1;ce=se&ye,v[ce]=M<<24|F<<16|he-y|0}}return se!==0&&(v[he+se]=I-C<<24|64<<16|0),S.bits=M,0},cd}var u2;function T_(){if(u2)return hn;u2=1;var t=Lr(),e=Jy(),n=e2(),r=C_(),o=I_(),i=0,s=1,a=2,c=4,l=5,u=6,f=0,d=1,h=2,p=-2,b=-3,v=-4,y=-5,A=8,S=1,E=2,I=3,_=4,B=5,N=6,M=7,F=8,C=9,Y=10,Q=11,se=12,oe=13,ae=14,ce=15,ye=16,he=17,De=18,we=19,Ee=20,Ie=21,Ge=22,Ve=23,q=24,j=25,ee=26,J=27,fe=28,L=29,D=30,te=31,le=32,Be=852,ve=592,Ae=15,Re=Ae;function dt(G){return(G>>>24&255)+(G>>>8&65280)+((G&65280)<<8)+((G&255)<<24)}function $t(){this.mode=0,this.last=!1,this.wrap=0,this.havedict=!1,this.flags=0,this.dmax=0,this.check=0,this.total=0,this.head=null,this.wbits=0,this.wsize=0,this.whave=0,this.wnext=0,this.window=null,this.hold=0,this.bits=0,this.length=0,this.offset=0,this.extra=0,this.lencode=null,this.distcode=null,this.lenbits=0,this.distbits=0,this.ncode=0,this.nlen=0,this.ndist=0,this.have=0,this.next=null,this.lens=new t.Buf16(320),this.work=new t.Buf16(288),this.lendyn=null,this.distdyn=null,this.sane=0,this.back=0,this.was=0}function It(G){var X;return!G||!G.state?p:(X=G.state,G.total_in=G.total_out=X.total=0,G.msg="",X.wrap&&(G.adler=X.wrap&1),X.mode=S,X.last=0,X.havedict=0,X.dmax=32768,X.head=null,X.hold=0,X.bits=0,X.lencode=X.lendyn=new t.Buf32(Be),X.distcode=X.distdyn=new t.Buf32(ve),X.sane=1,X.back=-1,f)}function $e(G){var X;return!G||!G.state?p:(X=G.state,X.wsize=0,X.whave=0,X.wnext=0,It(G))}function Rt(G,X){var T,re;return!G||!G.state||(re=G.state,X<0?(T=0,X=-X):(T=(X>>4)+1,X<48&&(X&=15)),X&&(X<8||X>15))?p:(re.window!==null&&re.wbits!==X&&(re.window=null),re.wrap=T,re.wbits=X,$e(G))}function Nt(G,X){var T,re;return G?(re=new $t,G.state=re,re.window=null,T=Rt(G,X),T!==f&&(G.state=null),T):p}function et(G){return Nt(G,Re)}var zt=!0,k,m;function w(G){if(zt){var X;for(k=new t.Buf32(512),m=new t.Buf32(32),X=0;X<144;)G.lens[X++]=8;for(;X<256;)G.lens[X++]=9;for(;X<280;)G.lens[X++]=7;for(;X<288;)G.lens[X++]=8;for(o(s,G.lens,0,288,k,0,G.work,{bits:9}),X=0;X<32;)G.lens[X++]=5;o(a,G.lens,0,32,m,0,G.work,{bits:5}),zt=!1}G.lencode=k,G.lenbits=9,G.distcode=m,G.distbits=5}function O(G,X,T,re){var _e,g=G.state;return g.window===null&&(g.wsize=1<<g.wbits,g.wnext=0,g.whave=0,g.window=new t.Buf8(g.wsize)),re>=g.wsize?(t.arraySet(g.window,X,T-g.wsize,g.wsize,0),g.wnext=0,g.whave=g.wsize):(_e=g.wsize-g.wnext,_e>re&&(_e=re),t.arraySet(g.window,X,T-re,_e,g.wnext),re-=_e,re?(t.arraySet(g.window,X,T-re,re,0),g.wnext=re,g.whave=g.wsize):(g.wnext+=_e,g.wnext===g.wsize&&(g.wnext=0),g.whave<g.wsize&&(g.whave+=_e))),0}function x(G,X){var T,re,_e,g,K,$,R,H,Z,Ce,me,xe,Ue,bn,U=0,Me,lt,tt,Tt,ke,ar,ft,Ne,ht=new t.Buf8(4),Bn,on,$a=[16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15];if(!G||!G.state||!G.output||!G.input&&G.avail_in!==0)return p;T=G.state,T.mode===se&&(T.mode=oe),K=G.next_out,_e=G.output,R=G.avail_out,g=G.next_in,re=G.input,$=G.avail_in,H=T.hold,Z=T.bits,Ce=$,me=R,Ne=f;e:for(;;)switch(T.mode){case S:if(T.wrap===0){T.mode=oe;break}for(;Z<16;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(T.wrap&2&&H===35615){T.check=0,ht[0]=H&255,ht[1]=H>>>8&255,T.check=n(T.check,ht,2,0),H=0,Z=0,T.mode=E;break}if(T.flags=0,T.head&&(T.head.done=!1),!(T.wrap&1)||(((H&255)<<8)+(H>>8))%31){G.msg="incorrect header check",T.mode=D;break}if((H&15)!==A){G.msg="unknown compression method",T.mode=D;break}if(H>>>=4,Z-=4,ft=(H&15)+8,T.wbits===0)T.wbits=ft;else if(ft>T.wbits){G.msg="invalid window size",T.mode=D;break}T.dmax=1<<ft,G.adler=T.check=1,T.mode=H&512?Y:se,H=0,Z=0;break;case E:for(;Z<16;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(T.flags=H,(T.flags&255)!==A){G.msg="unknown compression method",T.mode=D;break}if(T.flags&57344){G.msg="unknown header flags 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Array(T.head.extra_len)),t.arraySet(T.head.extra,re,g,xe,ft)),T.flags&512&&(T.check=n(T.check,re,xe,g)),$-=xe,g+=xe,T.length-=xe),T.length))break e;T.length=0,T.mode=M;case M:if(T.flags&2048){if($===0)break e;xe=0;do ft=re[g+xe++],T.head&&ft&&T.length<65536&&(T.head.name+=String.fromCharCode(ft));while(ft&&xe<$);if(T.flags&512&&(T.check=n(T.check,re,xe,g)),$-=xe,g+=xe,ft)break e}else T.head&&(T.head.name=null);T.length=0,T.mode=F;case F:if(T.flags&4096){if($===0)break e;xe=0;do ft=re[g+xe++],T.head&&ft&&T.length<65536&&(T.head.comment+=String.fromCharCode(ft));while(ft&&xe<$);if(T.flags&512&&(T.check=n(T.check,re,xe,g)),$-=xe,g+=xe,ft)break e}else T.head&&(T.head.comment=null);T.mode=C;case C:if(T.flags&512){for(;Z<16;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(H!==(T.check&65535)){G.msg="header crc mismatch",T.mode=D;break}H=0,Z=0}T.head&&(T.head.hcrc=T.flags>>9&1,T.head.done=!0),G.adler=T.check=0,T.mode=se;break;case Y:for(;Z<32;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}G.adler=T.check=dt(H),H=0,Z=0,T.mode=Q;case Q:if(T.havedict===0)return G.next_out=K,G.avail_out=R,G.next_in=g,G.avail_in=$,T.hold=H,T.bits=Z,h;G.adler=T.check=1,T.mode=se;case se:if(X===l||X===u)break e;case oe:if(T.last){H>>>=Z&7,Z-=Z&7,T.mode=J;break}for(;Z<3;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}switch(T.last=H&1,H>>>=1,Z-=1,H&3){case 0:T.mode=ae;break;case 1:if(w(T),T.mode=Ee,X===u){H>>>=2,Z-=2;break e}break;case 2:T.mode=he;break;case 3:G.msg="invalid block type",T.mode=D}H>>>=2,Z-=2;break;case ae:for(H>>>=Z&7,Z-=Z&7;Z<32;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if((H&65535)!==(H>>>16^65535)){G.msg="invalid stored block lengths",T.mode=D;break}if(T.length=H&65535,H=0,Z=0,T.mode=ce,X===u)break e;case ce:T.mode=ye;case ye:if(xe=T.length,xe){if(xe>$&&(xe=$),xe>R&&(xe=R),xe===0)break e;t.arraySet(_e,re,g,xe,K),$-=xe,g+=xe,R-=xe,K+=xe,T.length-=xe;break}T.mode=se;break;case he:for(;Z<14;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(T.nlen=(H&31)+257,H>>>=5,Z-=5,T.ndist=(H&31)+1,H>>>=5,Z-=5,T.ncode=(H&15)+4,H>>>=4,Z-=4,T.nlen>286||T.ndist>30){G.msg="too many length or distance symbols",T.mode=D;break}T.have=0,T.mode=De;case De:for(;T.have<T.ncode;){for(;Z<3;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}T.lens[$a[T.have++]]=H&7,H>>>=3,Z-=3}for(;T.have<19;)T.lens[$a[T.have++]]=0;if(T.lencode=T.lendyn,T.lenbits=7,Bn={bits:T.lenbits},Ne=o(i,T.lens,0,19,T.lencode,0,T.work,Bn),T.lenbits=Bn.bits,Ne){G.msg="invalid code lengths set",T.mode=D;break}T.have=0,T.mode=we;case we:for(;T.have<T.nlen+T.ndist;){for(;U=T.lencode[H&(1<<T.lenbits)-1],Me=U>>>24,lt=U>>>16&255,tt=U&65535,!(Me<=Z);){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(tt<16)H>>>=Me,Z-=Me,T.lens[T.have++]=tt;else{if(tt===16){for(on=Me+2;Z<on;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(H>>>=Me,Z-=Me,T.have===0){G.msg="invalid bit length repeat",T.mode=D;break}ft=T.lens[T.have-1],xe=3+(H&3),H>>>=2,Z-=2}else if(tt===17){for(on=Me+3;Z<on;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}H>>>=Me,Z-=Me,ft=0,xe=3+(H&7),H>>>=3,Z-=3}else{for(on=Me+7;Z<on;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}H>>>=Me,Z-=Me,ft=0,xe=11+(H&127),H>>>=7,Z-=7}if(T.have+xe>T.nlen+T.ndist){G.msg="invalid bit length repeat",T.mode=D;break}for(;xe--;)T.lens[T.have++]=ft}}if(T.mode===D)break;if(T.lens[256]===0){G.msg="invalid code -- missing end-of-block",T.mode=D;break}if(T.lenbits=9,Bn={bits:T.lenbits},Ne=o(s,T.lens,0,T.nlen,T.lencode,0,T.work,Bn),T.lenbits=Bn.bits,Ne){G.msg="invalid literal/lengths set",T.mode=D;break}if(T.distbits=6,T.distcode=T.distdyn,Bn={bits:T.distbits},Ne=o(a,T.lens,T.nlen,T.ndist,T.distcode,0,T.work,Bn),T.distbits=Bn.bits,Ne){G.msg="invalid distances set",T.mode=D;break}if(T.mode=Ee,X===u)break e;case Ee:T.mode=Ie;case Ie:if($>=6&&R>=258){G.next_out=K,G.avail_out=R,G.next_in=g,G.avail_in=$,T.hold=H,T.bits=Z,r(G,me),K=G.next_out,_e=G.output,R=G.avail_out,g=G.next_in,re=G.input,$=G.avail_in,H=T.hold,Z=T.bits,T.mode===se&&(T.back=-1);break}for(T.back=0;U=T.lencode[H&(1<<T.lenbits)-1],Me=U>>>24,lt=U>>>16&255,tt=U&65535,!(Me<=Z);){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(lt&&!(lt&240)){for(Tt=Me,ke=lt,ar=tt;U=T.lencode[ar+((H&(1<<Tt+ke)-1)>>Tt)],Me=U>>>24,lt=U>>>16&255,tt=U&65535,!(Tt+Me<=Z);){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}H>>>=Tt,Z-=Tt,T.back+=Tt}if(H>>>=Me,Z-=Me,T.back+=Me,T.length=tt,lt===0){T.mode=ee;break}if(lt&32){T.back=-1,T.mode=se;break}if(lt&64){G.msg="invalid literal/length code",T.mode=D;break}T.extra=lt&15,T.mode=Ge;case Ge:if(T.extra){for(on=T.extra;Z<on;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}T.length+=H&(1<<T.extra)-1,H>>>=T.extra,Z-=T.extra,T.back+=T.extra}T.was=T.length,T.mode=Ve;case Ve:for(;U=T.distcode[H&(1<<T.distbits)-1],Me=U>>>24,lt=U>>>16&255,tt=U&65535,!(Me<=Z);){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(!(lt&240)){for(Tt=Me,ke=lt,ar=tt;U=T.distcode[ar+((H&(1<<Tt+ke)-1)>>Tt)],Me=U>>>24,lt=U>>>16&255,tt=U&65535,!(Tt+Me<=Z);){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}H>>>=Tt,Z-=Tt,T.back+=Tt}if(H>>>=Me,Z-=Me,T.back+=Me,lt&64){G.msg="invalid distance code",T.mode=D;break}T.offset=tt,T.extra=lt&15,T.mode=q;case q:if(T.extra){for(on=T.extra;Z<on;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}T.offset+=H&(1<<T.extra)-1,H>>>=T.extra,Z-=T.extra,T.back+=T.extra}if(T.offset>T.dmax){G.msg="invalid distance too far back",T.mode=D;break}T.mode=j;case j:if(R===0)break e;if(xe=me-R,T.offset>xe){if(xe=T.offset-xe,xe>T.whave&&T.sane){G.msg="invalid distance too far back",T.mode=D;break}xe>T.wnext?(xe-=T.wnext,Ue=T.wsize-xe):Ue=T.wnext-xe,xe>T.length&&(xe=T.length),bn=T.window}else bn=_e,Ue=K-T.offset,xe=T.length;xe>R&&(xe=R),R-=xe,T.length-=xe;do _e[K++]=bn[Ue++];while(--xe);T.length===0&&(T.mode=Ie);break;case ee:if(R===0)break e;_e[K++]=T.length,R--,T.mode=Ie;break;case J:if(T.wrap){for(;Z<32;){if($===0)break e;$--,H|=re[g++]<<Z,Z+=8}if(me-=R,G.total_out+=me,T.total+=me,me&&(G.adler=T.check=T.flags?n(T.check,_e,me,K-me):e(T.check,_e,me,K-me)),me=R,(T.flags?H:dt(H))!==T.check){G.msg="incorrect data check",T.mode=D;break}H=0,Z=0}T.mode=fe;case fe:if(T.wrap&&T.flags){for(;Z<32;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(H!==(T.total&4294967295)){G.msg="incorrect length check",T.mode=D;break}H=0,Z=0}T.mode=L;case L:Ne=d;break e;case D:Ne=b;break e;case te:return v;case le:default:return p}return 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hn.inflateReset=$e,hn.inflateReset2=Rt,hn.inflateResetKeep=It,hn.inflateInit=et,hn.inflateInit2=Nt,hn.inflate=x,hn.inflateEnd=z,hn.inflateGetHeader=V,hn.inflateSetDictionary=ue,hn.inflateInfo="pako inflate (from Nodeca project)",hn}var ld,f2;function h2(){return f2||(f2=1,ld={Z_NO_FLUSH:0,Z_PARTIAL_FLUSH:1,Z_SYNC_FLUSH:2,Z_FULL_FLUSH:3,Z_FINISH:4,Z_BLOCK:5,Z_TREES:6,Z_OK:0,Z_STREAM_END:1,Z_NEED_DICT:2,Z_ERRNO:-1,Z_STREAM_ERROR:-2,Z_DATA_ERROR:-3,Z_BUF_ERROR:-5,Z_NO_COMPRESSION:0,Z_BEST_SPEED:1,Z_BEST_COMPRESSION:9,Z_DEFAULT_COMPRESSION:-1,Z_FILTERED:1,Z_HUFFMAN_ONLY:2,Z_RLE:3,Z_FIXED:4,Z_DEFAULT_STRATEGY:0,Z_BINARY:0,Z_TEXT:1,Z_UNKNOWN:2,Z_DEFLATED:8}),ld}var ud,d2;function D_(){if(d2)return ud;d2=1;function t(){this.text=0,this.time=0,this.xflags=0,this.os=0,this.extra=null,this.extra_len=0,this.name="",this.comment="",this.hcrc=0,this.done=!1}return ud=t,ud}var p2;function B_(){if(p2)return yo;p2=1;var 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h.result}function u(f,d){return d=d||{},d.raw=!0,l(f,d)}return yo.Inflate=c,yo.inflate=l,yo.inflateRaw=u,yo.ungzip=l,yo}var fd,g2;function k_(){if(g2)return fd;g2=1;var t=Lr().assign,e=S_(),n=B_(),r=h2(),o={};return t(o,e,n,r),fd=o,fd}var Ll=k_();async function Or(t){try{let e,n=0,r=0;const o=[];let i=0,s;do{const c=t.subarray(n);if(s=new Ll.Inflate,{strm:e}=s,s.push(c,Ll.Z_SYNC_FLUSH),s.err)throw new Error(s.msg);n+=e.next_in,o[r]=s.result,i+=o[r].length,r+=1}while(e.avail_in);const a=new Uint8Array(i);for(let c=0,l=0;c<o.length;c++)a.set(o[c],l),l+=o[c].length;return Ke.Buffer.from(a)}catch(e){throw/incorrect header check/.exec(`${e}`)?new Error("problem decompressing block: incorrect gzip header check"):e}}async function m2(t,e){try{let n;const{minv:r,maxv:o}=e;let i=r.blockPosition,s=r.dataPosition;const a=[],c=[],l=[];let u=0,f=0;do{const p=t.subarray(i-r.blockPosition),b=new Ll.Inflate;if({strm:n}=b,b.push(p,Ll.Z_SYNC_FLUSH),b.err)throw new Error(b.msg);const v=b.result;a.push(v);let y=v.length;c.push(i),l.push(s),a.length===1&&r.dataPosition&&(a[0]=a[0].subarray(r.dataPosition),y=a[0].length);const A=i;if(i+=n.next_in,s+=y,A>=o.blockPosition){a[f]=a[f].subarray(0,o.blockPosition===r.blockPosition?o.dataPosition-r.dataPosition+1:o.dataPosition+1),c.push(i),l.push(s),u+=a[f].length;break}u+=a[f].length,f++}while(n.avail_in);const d=new Uint8Array(u);for(let p=0,b=0;p<a.length;p++)d.set(a[p],b),b+=a[p].length;return{buffer:Ke.Buffer.from(d),cpositions:c,dpositions:l}}catch(n){throw/incorrect header check/.exec(`${n}`)?new Error("problem decompressing block: incorrect gzip header check"):n}}var hd,b2;function __(){if(b2)return hd;b2=1,hd=e;var t=null;try{t=new WebAssembly.Instance(new WebAssembly.Module(new 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e(F,C,Y){this.low=F|0,this.high=C|0,this.unsigned=!!Y}e.prototype.__isLong__,Object.defineProperty(e.prototype,"__isLong__",{value:!0});function n(F){return(F&&F.__isLong__)===!0}e.isLong=n;var r={},o={};function i(F,C){var Y,Q,se;return C?(F>>>=0,(se=0<=F&&F<256)&&(Q=o[F],Q)?Q:(Y=a(F,(F|0)<0?-1:0,!0),se&&(o[F]=Y),Y)):(F|=0,(se=-128<=F&&F<128)&&(Q=r[F],Q)?Q:(Y=a(F,F<0?-1:0,!1),se&&(r[F]=Y),Y))}e.fromInt=i;function s(F,C){if(isNaN(F))return C?A:y;if(C){if(F<0)return A;if(F>=p)return B}else{if(F<=-9223372036854776e3)return N;if(F+1>=b)return _}return F<0?s(-F,C).neg():a(F%h|0,F/h|0,C)}e.fromNumber=s;function a(F,C,Y){return new e(F,C,Y)}e.fromBits=a;var c=Math.pow;function l(F,C,Y){if(F.length===0)throw Error("empty string");if(F==="NaN"||F==="Infinity"||F==="+Infinity"||F==="-Infinity")return y;if(typeof C=="number"?(Y=C,C=!1):C=!!C,Y=Y||10,Y<2||36<Y)throw RangeError("radix");var Q;if((Q=F.indexOf("-"))>0)throw Error("interior hyphen");if(Q===0)return l(F.substring(1),C,Y).neg();for(var se=s(c(Y,8)),oe=y,ae=0;ae<F.length;ae+=8){var ce=Math.min(8,F.length-ae),ye=parseInt(F.substring(ae,ae+ce),Y);if(ce<8){var he=s(c(Y,ce));oe=oe.mul(he).add(s(ye))}else oe=oe.mul(se),oe=oe.add(s(ye))}return oe.unsigned=C,oe}e.fromString=l;function u(F,C){return typeof F=="number"?s(F,C):typeof F=="string"?l(F,C):a(F.low,F.high,typeof C=="boolean"?C:F.unsigned)}e.fromValue=u;var f=65536,d=1<<24,h=f*f,p=h*h,b=p/2,v=i(d),y=i(0);e.ZERO=y;var A=i(0,!0);e.UZERO=A;var S=i(1);e.ONE=S;var E=i(1,!0);e.UONE=E;var I=i(-1);e.NEG_ONE=I;var _=a(-1,2147483647,!1);e.MAX_VALUE=_;var B=a(-1,-1,!0);e.MAX_UNSIGNED_VALUE=B;var N=a(0,-2147483648,!1);e.MIN_VALUE=N;var M=e.prototype;return M.toInt=function(){return this.unsigned?this.low>>>0:this.low},M.toNumber=function(){return this.unsigned?(this.high>>>0)*h+(this.low>>>0):this.high*h+(this.low>>>0)},M.toString=function(C){if(C=C||10,C<2||36<C)throw RangeError("radix");if(this.isZero())return"0";if(this.isNegative())if(this.eq(N)){var Y=s(C),Q=this.div(Y),se=Q.mul(Y).sub(this);return Q.toString(C)+se.toInt().toString(C)}else return"-"+this.neg().toString(C);for(var oe=s(c(C,6),this.unsigned),ae=this,ce="";;){var ye=ae.div(oe),he=ae.sub(ye.mul(oe)).toInt()>>>0,De=he.toString(C);if(ae=ye,ae.isZero())return De+ce;for(;De.length<6;)De="0"+De;ce=""+De+ce}},M.getHighBits=function(){return this.high},M.getHighBitsUnsigned=function(){return this.high>>>0},M.getLowBits=function(){return this.low},M.getLowBitsUnsigned=function(){return this.low>>>0},M.getNumBitsAbs=function(){if(this.isNegative())return this.eq(N)?64:this.neg().getNumBitsAbs();for(var C=this.high!=0?this.high:this.low,Y=31;Y>0&&!(C&1<<Y);Y--);return this.high!=0?Y+33:Y+1},M.isZero=function(){return this.high===0&&this.low===0},M.eqz=M.isZero,M.isNegative=function(){return!this.unsigned&&this.high<0},M.isPositive=function(){return this.unsigned||this.high>=0},M.isOdd=function(){return(this.low&1)===1},M.isEven=function(){return(this.low&1)===0},M.equals=function(C){return n(C)||(C=u(C)),this.unsigned!==C.unsigned&&this.high>>>31===1&&C.high>>>31===1?!1:this.high===C.high&&this.low===C.low},M.eq=M.equals,M.notEquals=function(C){return!this.eq(C)},M.neq=M.notEquals,M.ne=M.notEquals,M.lessThan=function(C){return this.comp(C)<0},M.lt=M.lessThan,M.lessThanOrEqual=function(C){return this.comp(C)<=0},M.lte=M.lessThanOrEqual,M.le=M.lessThanOrEqual,M.greaterThan=function(C){return this.comp(C)>0},M.gt=M.greaterThan,M.greaterThanOrEqual=function(C){return this.comp(C)>=0},M.gte=M.greaterThanOrEqual,M.ge=M.greaterThanOrEqual,M.compare=function(C){if(n(C)||(C=u(C)),this.eq(C))return 0;var Y=this.isNegative(),Q=C.isNegative();return 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C.isNegative()?this.neg().mul(C.neg()):this.neg().mul(C).neg();if(C.isNegative())return this.mul(C.neg()).neg();if(this.lt(v)&&C.lt(v))return s(this.toNumber()*C.toNumber(),this.unsigned);var Q=this.high>>>16,se=this.high&65535,oe=this.low>>>16,ae=this.low&65535,ce=C.high>>>16,ye=C.high&65535,he=C.low>>>16,De=C.low&65535,we=0,Ee=0,Ie=0,Ge=0;return Ge+=ae*De,Ie+=Ge>>>16,Ge&=65535,Ie+=oe*De,Ee+=Ie>>>16,Ie&=65535,Ie+=ae*he,Ee+=Ie>>>16,Ie&=65535,Ee+=se*De,we+=Ee>>>16,Ee&=65535,Ee+=oe*he,we+=Ee>>>16,Ee&=65535,Ee+=ae*ye,we+=Ee>>>16,Ee&=65535,we+=Q*De+se*he+oe*ye+ae*ce,we&=65535,a(Ie<<16|Ge,we<<16|Ee,this.unsigned)},M.mul=M.multiply,M.divide=function(C){if(n(C)||(C=u(C)),C.isZero())throw Error("division by zero");if(t){if(!this.unsigned&&this.high===-2147483648&&C.low===-1&&C.high===-1)return this;var Y=(this.unsigned?t.div_u:t.div_s)(this.low,this.high,C.low,C.high);return a(Y,t.get_high(),this.unsigned)}if(this.isZero())return this.unsigned?A:y;var Q,se,oe;if(this.unsigned){if(C.unsigned||(C=C.toUnsigned()),C.gt(this))return A;if(C.gt(this.shru(1)))return E;oe=A}else{if(this.eq(N)){if(C.eq(S)||C.eq(I))return N;if(C.eq(N))return S;var ae=this.shr(1);return Q=ae.div(C).shl(1),Q.eq(y)?C.isNegative()?S:I:(se=this.sub(C.mul(Q)),oe=Q.add(se.div(C)),oe)}else if(C.eq(N))return this.unsigned?A:y;if(this.isNegative())return C.isNegative()?this.neg().div(C.neg()):this.neg().div(C).neg();if(C.isNegative())return this.div(C.neg()).neg();oe=y}for(se=this;se.gte(C);){Q=Math.max(1,Math.floor(se.toNumber()/C.toNumber()));for(var ce=Math.ceil(Math.log(Q)/Math.LN2),ye=ce<=48?1:c(2,ce-48),he=s(Q),De=he.mul(C);De.isNegative()||De.gt(se);)Q-=ye,he=s(Q,this.unsigned),De=he.mul(C);he.isZero()&&(he=S),oe=oe.add(he),se=se.sub(De)}return oe},M.div=M.divide,M.modulo=function(C){if(n(C)||(C=u(C)),t){var Y=(this.unsigned?t.rem_u:t.rem_s)(this.low,this.high,C.low,C.high);return a(Y,t.get_high(),this.unsigned)}return this.sub(this.div(C).mul(C))},M.mod=M.modulo,M.rem=M.modulo,M.not=function(){return a(~this.low,~this.high,this.unsigned)},M.and=function(C){return n(C)||(C=u(C)),a(this.low&C.low,this.high&C.high,this.unsigned)},M.or=function(C){return n(C)||(C=u(C)),a(this.low|C.low,this.high|C.high,this.unsigned)},M.xor=function(C){return n(C)||(C=u(C)),a(this.low^C.low,this.high^C.high,this.unsigned)},M.shiftLeft=function(C){return n(C)&&(C=C.toInt()),(C&=63)===0?this:C<32?a(this.low<<C,this.high<<C|this.low>>>32-C,this.unsigned):a(0,this.low<<C-32,this.unsigned)},M.shl=M.shiftLeft,M.shiftRight=function(C){return n(C)&&(C=C.toInt()),(C&=63)===0?this:C<32?a(this.low>>>C|this.high<<32-C,this.high>>C,this.unsigned):a(this.high>>C-32,this.high>=0?0:-1,this.unsigned)},M.shr=M.shiftRight,M.shiftRightUnsigned=function(C){if(n(C)&&(C=C.toInt()),C&=63,C===0)return this;var Y=this.high;if(C<32){var Q=this.low;return a(Q>>>C|Y<<32-C,Y>>>C,this.unsigned)}else return C===32?a(Y,0,this.unsigned):a(Y>>>C-32,0,this.unsigned)},M.shru=M.shiftRightUnsigned,M.shr_u=M.shiftRightUnsigned,M.toSigned=function(){return this.unsigned?a(this.low,this.high,!1):this},M.toUnsigned=function(){return this.unsigned?this:a(this.low,this.high,!0)},M.toBytes=function(C){return C?this.toBytesLE():this.toBytesBE()},M.toBytesLE=function(){var C=this.high,Y=this.low;return[Y&255,Y>>>8&255,Y>>>16&255,Y>>>24,C&255,C>>>8&255,C>>>16&255,C>>>24]},M.toBytesBE=function(){var C=this.high,Y=this.low;return[C>>>24,C>>>16&255,C>>>8&255,C&255,Y>>>24,Y>>>16&255,Y>>>8&255,Y&255]},e.fromBytes=function(C,Y,Q){return Q?e.fromBytesLE(C,Y):e.fromBytesBE(C,Y)},e.fromBytesLE=function(C,Y){return new e(C[0]|C[1]<<8|C[2]<<16|C[3]<<24,C[4]|C[5]<<8|C[6]<<16|C[7]<<24,Y)},e.fromBytesBE=function(C,Y){return new e(C[4]<<24|C[5]<<16|C[6]<<8|C[7],C[0]<<24|C[1]<<16|C[2]<<8|C[3],Y)},hd}var R_=__();const Ol=Ml(R_),Nl=1;class F_{constructor({filehandle:e,path:n}){if(e)this.filehandle=e;else 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o=await this._getIndex(),i=[],s=(d,h)=>{const p=d[Nl],b=h?h[Nl]:1/0;return p<=n&&b>n?0:p<n?-1:1};let a=0,c=o.length-1,l=Math.floor(o.length/2),u=s(o[l],o[l+1]);for(;u!==0;)u>0?c=l-1:u<0&&(a=l+1),l=Math.ceil((c-a)/2)+a,u=s(o[l],o[l+1]);i.push(o[l]);let f=l+1;for(;f<o.length&&(i.push(o[f]),!(o[f][Nl]>=r));f+=1);return i[i.length-1][Nl]<r&&i.push([]),i}}class y2{constructor({filehandle:e,path:n,gziFilehandle:r,gziPath:o}){if(e)this.filehandle=e;else if(n)this.filehandle=new Ct(n);else throw new TypeError("either filehandle or path must be defined");if(!r&&!o&&!n)throw new TypeError("either gziFilehandle or gziPath must be defined");this.gzi=new F_({filehandle:r,path:!r&&!o&&n?o:`${n}.gzi`})}async stat(){const e=await this.filehandle.stat();return Object.assign(e,{size:await this.getUncompressedFileSize(),blocks:void 0,blksize:void 0})}async getUncompressedFileSize(){const[,e]=await this.gzi.getLastBlock(),{size:n}=await this.filehandle.stat(),r=Ke.Buffer.allocUnsafe(4),{bytesRead:o}=await 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t.split(">").filter(e=>/\S/.test(e)).map(e=>{const[n,...r]=e.split(`
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|
651
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aR(i,o)},lR=(t,e)=>{e=e||t.length,e>t.length&&(e=t.length);let n=e-1;for(;n>=0&&(t[n]&192)===128;)n--;return n<0||n===0?e:n+Sa[t[n]]>e?n:e},md={string2buf:sR,buf2string:cR,utf8border:lR};function uR(){this.input=null,this.next_in=0,this.avail_in=0,this.total_in=0,this.output=null,this.next_out=0,this.avail_out=0,this.total_out=0,this.msg="",this.state=null,this.data_type=2,this.adler=0}var fR=uR;const Ul=16209,hR=16191;var dR=function(e,n){let r,o,i,s,a,c,l,u,f,d,h,p,b,v,y,A,S,E,I,_,B,N,M,F;const C=e.state;r=e.next_in,M=e.input,o=r+(e.avail_in-5),i=e.next_out,F=e.output,s=i-(n-e.avail_out),a=i+(e.avail_out-257),c=C.dmax,l=C.wsize,u=C.whave,f=C.wnext,d=C.window,h=C.hold,p=C.bits,b=C.lencode,v=C.distcode,y=(1<<C.lenbits)-1,A=(1<<C.distbits)-1;e:do{p<15&&(h+=M[r++]<<p,p+=8,h+=M[r++]<<p,p+=8),S=b[h&y];t:for(;;){if(E=S>>>24,h>>>=E,p-=E,E=S>>>16&255,E===0)F[i++]=S&65535;else if(E&16){I=S&65535,E&=15,E&&(p<E&&(h+=M[r++]<<p,p+=8),I+=h&(1<<E)-1,h>>>=E,p-=E),p<15&&(h+=M[r++]<<p,p+=8,h+=M[r++]<<p,p+=8),S=v[h&A];n:for(;;){if(E=S>>>24,h>>>=E,p-=E,E=S>>>16&255,E&16){if(_=S&65535,E&=15,p<E&&(h+=M[r++]<<p,p+=8,p<E&&(h+=M[r++]<<p,p+=8)),_+=h&(1<<E)-1,_>c){e.msg="invalid distance too far back",C.mode=Ul;break e}if(h>>>=E,p-=E,E=i-s,_>E){if(E=_-E,E>u&&C.sane){e.msg="invalid distance too far back",C.mode=Ul;break e}if(B=0,N=d,f===0){if(B+=l-E,E<I){I-=E;do F[i++]=d[B++];while(--E);B=i-_,N=F}}else if(f<E){if(B+=l+f-E,E-=f,E<I){I-=E;do F[i++]=d[B++];while(--E);if(B=0,f<I){E=f,I-=E;do F[i++]=d[B++];while(--E);B=i-_,N=F}}}else if(B+=f-E,E<I){I-=E;do F[i++]=d[B++];while(--E);B=i-_,N=F}for(;I>2;)F[i++]=N[B++],F[i++]=N[B++],F[i++]=N[B++],I-=3;I&&(F[i++]=N[B++],I>1&&(F[i++]=N[B++]))}else{B=i-_;do F[i++]=F[B++],F[i++]=F[B++],F[i++]=F[B++],I-=3;while(I>2);I&&(F[i++]=F[B++],I>1&&(F[i++]=F[B++]))}}else if(E&64){e.msg="invalid distance code",C.mode=Ul;break e}else{S=v[(S&65535)+(h&(1<<E)-1)];continue n}break}}else if(E&64)if(E&32){C.mode=hR;break e}else{e.msg="invalid literal/length code",C.mode=Ul;break e}else{S=b[(S&65535)+(h&(1<<E)-1)];continue t}break}}while(r<o&&i<a);I=p>>3,r-=I,p-=I<<3,h&=(1<<p)-1,e.next_in=r,e.next_out=i,e.avail_in=r<o?5+(o-r):5-(r-o),e.avail_out=i<a?257+(a-i):257-(i-a),C.hold=h,C.bits=p};const vo=15,B2=852,k2=592,_2=0,bd=1,R2=2,pR=new Uint16Array([3,4,5,6,7,8,9,10,11,13,15,17,19,23,27,31,35,43,51,59,67,83,99,115,131,163,195,227,258,0,0]),gR=new Uint8Array([16,16,16,16,16,16,16,16,17,17,17,17,18,18,18,18,19,19,19,19,20,20,20,20,21,21,21,21,16,72,78]),mR=new Uint16Array([1,2,3,4,5,7,9,13,17,25,33,49,65,97,129,193,257,385,513,769,1025,1537,2049,3073,4097,6145,8193,12289,16385,24577,0,0]),bR=new Uint8Array([16,16,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,29,29,64,64]);var Ca=(t,e,n,r,o,i,s,a)=>{const c=a.bits;let l=0,u=0,f=0,d=0,h=0,p=0,b=0,v=0,y=0,A=0,S,E,I,_,B,N=null,M;const F=new Uint16Array(vo+1),C=new Uint16Array(vo+1);let Y=null,Q,se,oe;for(l=0;l<=vo;l++)F[l]=0;for(u=0;u<r;u++)F[e[n+u]]++;for(h=c,d=vo;d>=1&&F[d]===0;d--);if(h>d&&(h=d),d===0)return o[i++]=1<<24|64<<16|0,o[i++]=1<<24|64<<16|0,a.bits=1,0;for(f=1;f<d&&F[f]===0;f++);for(h<f&&(h=f),v=1,l=1;l<=vo;l++)if(v<<=1,v-=F[l],v<0)return-1;if(v>0&&(t===_2||d!==1))return-1;for(C[1]=0,l=1;l<vo;l++)C[l+1]=C[l]+F[l];for(u=0;u<r;u++)e[n+u]!==0&&(s[C[e[n+u]]++]=u);if(t===_2?(N=Y=s,M=20):t===bd?(N=pR,Y=gR,M=257):(N=mR,Y=bR,M=0),A=0,u=0,l=f,B=i,p=h,b=0,I=-1,y=1<<h,_=y-1,t===bd&&y>B2||t===R2&&y>k2)return 1;for(;;){Q=l-b,s[u]+1<M?(se=0,oe=s[u]):s[u]>=M?(se=Y[s[u]-M],oe=N[s[u]-M]):(se=96,oe=0),S=1<<l-b,E=1<<p,f=E;do E-=S,o[B+(A>>b)+E]=Q<<24|se<<16|oe|0;while(E!==0);for(S=1<<l-1;A&S;)S>>=1;if(S!==0?(A&=S-1,A+=S):A=0,u++,--F[l]===0){if(l===d)break;l=e[n+s[u]]}if(l>h&&(A&_)!==I){for(b===0&&(b=h),B+=f,p=l-b,v=1<<p;p+b<d&&(v-=F[p+b],!(v<=0));)p++,v<<=1;if(y+=1<<p,t===bd&&y>B2||t===R2&&y>k2)return 1;I=A&_,o[I]=h<<24|p<<16|B-i|0}}return A!==0&&(o[B+A]=l-b<<24|64<<16|0),a.bits=h,0};const yR=0,F2=1,M2=2,{Z_FINISH:P2,Z_BLOCK:wR,Z_TREES:Gl,Z_OK:Si,Z_STREAM_END:xR,Z_NEED_DICT:vR,Z_STREAM_ERROR:dn,Z_DATA_ERROR:L2,Z_MEM_ERROR:O2,Z_BUF_ERROR:AR,Z_DEFLATED:N2}=I2,Hl=16180,z2=16181,U2=16182,G2=16183,H2=16184,V2=16185,q2=16186,j2=16187,W2=16188,Y2=16189,Vl=16190,tr=16191,yd=16192,Q2=16193,wd=16194,Z2=16195,X2=16196,K2=16197,J2=16198,ql=16199,jl=16200,$2=16201,ew=16202,tw=16203,nw=16204,rw=16205,xd=16206,iw=16207,ow=16208,ct=16209,sw=16210,aw=16211,ER=852,SR=592,CR=15,cw=t=>(t>>>24&255)+(t>>>8&65280)+((t&65280)<<8)+((t&255)<<24);function IR(){this.strm=null,this.mode=0,this.last=!1,this.wrap=0,this.havedict=!1,this.flags=0,this.dmax=0,this.check=0,this.total=0,this.head=null,this.wbits=0,this.wsize=0,this.whave=0,this.wnext=0,this.window=null,this.hold=0,this.bits=0,this.length=0,this.offset=0,this.extra=0,this.lencode=null,this.distcode=null,this.lenbits=0,this.distbits=0,this.ncode=0,this.nlen=0,this.ndist=0,this.have=0,this.next=null,this.lens=new Uint16Array(320),this.work=new Uint16Array(288),this.lendyn=null,this.distdyn=null,this.sane=0,this.back=0,this.was=0}const Ci=t=>{if(!t)return 1;const e=t.state;return!e||e.strm!==t||e.mode<Hl||e.mode>aw?1:0},lw=t=>{if(Ci(t))return dn;const e=t.state;return t.total_in=t.total_out=e.total=0,t.msg="",e.wrap&&(t.adler=e.wrap&1),e.mode=Hl,e.last=0,e.havedict=0,e.flags=-1,e.dmax=32768,e.head=null,e.hold=0,e.bits=0,e.lencode=e.lendyn=new Int32Array(ER),e.distcode=e.distdyn=new Int32Array(SR),e.sane=1,e.back=-1,Si},uw=t=>{if(Ci(t))return dn;const e=t.state;return e.wsize=0,e.whave=0,e.wnext=0,lw(t)},fw=(t,e)=>{let n;if(Ci(t))return dn;const r=t.state;return e<0?(n=0,e=-e):(n=(e>>4)+5,e<48&&(e&=15)),e&&(e<8||e>15)?dn:(r.window!==null&&r.wbits!==e&&(r.window=null),r.wrap=n,r.wbits=e,uw(t))},hw=(t,e)=>{if(!t)return dn;const n=new IR;t.state=n,n.strm=t,n.window=null,n.mode=Hl;const r=fw(t,e);return r!==Si&&(t.state=null),r},TR=t=>hw(t,CR);let dw=!0,vd,Ad;const DR=t=>{if(dw){vd=new Int32Array(512),Ad=new Int32Array(32);let e=0;for(;e<144;)t.lens[e++]=8;for(;e<256;)t.lens[e++]=9;for(;e<280;)t.lens[e++]=7;for(;e<288;)t.lens[e++]=8;for(Ca(F2,t.lens,0,288,vd,0,t.work,{bits:9}),e=0;e<32;)t.lens[e++]=5;Ca(M2,t.lens,0,32,Ad,0,t.work,{bits:5}),dw=!1}t.lencode=vd,t.lenbits=9,t.distcode=Ad,t.distbits=5},pw=(t,e,n,r)=>{let o;const i=t.state;return i.window===null&&(i.wsize=1<<i.wbits,i.wnext=0,i.whave=0,i.window=new Uint8Array(i.wsize)),r>=i.wsize?(i.window.set(e.subarray(n-i.wsize,n),0),i.wnext=0,i.whave=i.wsize):(o=i.wsize-i.wnext,o>r&&(o=r),i.window.set(e.subarray(n-r,n-r+o),i.wnext),r-=o,r?(i.window.set(e.subarray(n-r,n),0),i.wnext=r,i.whave=i.wsize):(i.wnext+=o,i.wnext===i.wsize&&(i.wnext=0),i.whave<i.wsize&&(i.whave+=o))),0},BR=(t,e)=>{let n,r,o,i,s,a,c,l,u,f,d,h,p,b,v=0,y,A,S,E,I,_,B,N;const M=new Uint8Array(4);let F,C;const Y=new Uint8Array([16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15]);if(Ci(t)||!t.output||!t.input&&t.avail_in!==0)return dn;n=t.state,n.mode===tr&&(n.mode=yd),s=t.next_out,o=t.output,c=t.avail_out,i=t.next_in,r=t.input,a=t.avail_in,l=n.hold,u=n.bits,f=a,d=c,N=Si;e:for(;;)switch(n.mode){case Hl:if(n.wrap===0){n.mode=yd;break}for(;u<16;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(n.wrap&2&&l===35615){n.wbits===0&&(n.wbits=15),n.check=0,M[0]=l&255,M[1]=l>>>8&255,n.check=Vn(n.check,M,2,0),l=0,u=0,n.mode=z2;break}if(n.head&&(n.head.done=!1),!(n.wrap&1)||(((l&255)<<8)+(l>>8))%31){t.msg="incorrect header check",n.mode=ct;break}if((l&15)!==N2){t.msg="unknown compression method",n.mode=ct;break}if(l>>>=4,u-=4,B=(l&15)+8,n.wbits===0&&(n.wbits=B),B>15||B>n.wbits){t.msg="invalid window size",n.mode=ct;break}n.dmax=1<<n.wbits,n.flags=0,t.adler=n.check=1,n.mode=l&512?Y2:tr,l=0,u=0;break;case z2:for(;u<16;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(n.flags=l,(n.flags&255)!==N2){t.msg="unknown compression method",n.mode=ct;break}if(n.flags&57344){t.msg="unknown header flags set",n.mode=ct;break}n.head&&(n.head.text=l>>8&1),n.flags&512&&n.wrap&4&&(M[0]=l&255,M[1]=l>>>8&255,n.check=Vn(n.check,M,2,0)),l=0,u=0,n.mode=U2;case U2:for(;u<32;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}n.head&&(n.head.time=l),n.flags&512&&n.wrap&4&&(M[0]=l&255,M[1]=l>>>8&255,M[2]=l>>>16&255,M[3]=l>>>24&255,n.check=Vn(n.check,M,4,0)),l=0,u=0,n.mode=G2;case G2:for(;u<16;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}n.head&&(n.head.xflags=l&255,n.head.os=l>>8),n.flags&512&&n.wrap&4&&(M[0]=l&255,M[1]=l>>>8&255,n.check=Vn(n.check,M,2,0)),l=0,u=0,n.mode=H2;case H2:if(n.flags&1024){for(;u<16;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}n.length=l,n.head&&(n.head.extra_len=l),n.flags&512&&n.wrap&4&&(M[0]=l&255,M[1]=l>>>8&255,n.check=Vn(n.check,M,2,0)),l=0,u=0}else n.head&&(n.head.extra=null);n.mode=V2;case V2:if(n.flags&1024&&(h=n.length,h>a&&(h=a),h&&(n.head&&(B=n.head.extra_len-n.length,n.head.extra||(n.head.extra=new Uint8Array(n.head.extra_len)),n.head.extra.set(r.subarray(i,i+h),B)),n.flags&512&&n.wrap&4&&(n.check=Vn(n.check,r,h,i)),a-=h,i+=h,n.length-=h),n.length))break e;n.length=0,n.mode=q2;case q2:if(n.flags&2048){if(a===0)break e;h=0;do B=r[i+h++],n.head&&B&&n.length<65536&&(n.head.name+=String.fromCharCode(B));while(B&&h<a);if(n.flags&512&&n.wrap&4&&(n.check=Vn(n.check,r,h,i)),a-=h,i+=h,B)break e}else n.head&&(n.head.name=null);n.length=0,n.mode=j2;case j2:if(n.flags&4096){if(a===0)break e;h=0;do B=r[i+h++],n.head&&B&&n.length<65536&&(n.head.comment+=String.fromCharCode(B));while(B&&h<a);if(n.flags&512&&n.wrap&4&&(n.check=Vn(n.check,r,h,i)),a-=h,i+=h,B)break e}else n.head&&(n.head.comment=null);n.mode=W2;case W2:if(n.flags&512){for(;u<16;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(n.wrap&4&&l!==(n.check&65535)){t.msg="header crc mismatch",n.mode=ct;break}l=0,u=0}n.head&&(n.head.hcrc=n.flags>>9&1,n.head.done=!0),t.adler=n.check=0,n.mode=tr;break;case Y2:for(;u<32;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}t.adler=n.check=cw(l),l=0,u=0,n.mode=Vl;case Vl:if(n.havedict===0)return t.next_out=s,t.avail_out=c,t.next_in=i,t.avail_in=a,n.hold=l,n.bits=u,vR;t.adler=n.check=1,n.mode=tr;case tr:if(e===wR||e===Gl)break e;case yd:if(n.last){l>>>=u&7,u-=u&7,n.mode=xd;break}for(;u<3;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}switch(n.last=l&1,l>>>=1,u-=1,l&3){case 0:n.mode=Q2;break;case 1:if(DR(n),n.mode=ql,e===Gl){l>>>=2,u-=2;break e}break;case 2:n.mode=X2;break;case 3:t.msg="invalid block type",n.mode=ct}l>>>=2,u-=2;break;case Q2:for(l>>>=u&7,u-=u&7;u<32;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if((l&65535)!==(l>>>16^65535)){t.msg="invalid stored block lengths",n.mode=ct;break}if(n.length=l&65535,l=0,u=0,n.mode=wd,e===Gl)break e;case wd:n.mode=Z2;case Z2:if(h=n.length,h){if(h>a&&(h=a),h>c&&(h=c),h===0)break e;o.set(r.subarray(i,i+h),s),a-=h,i+=h,c-=h,s+=h,n.length-=h;break}n.mode=tr;break;case X2:for(;u<14;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(n.nlen=(l&31)+257,l>>>=5,u-=5,n.ndist=(l&31)+1,l>>>=5,u-=5,n.ncode=(l&15)+4,l>>>=4,u-=4,n.nlen>286||n.ndist>30){t.msg="too many length or distance symbols",n.mode=ct;break}n.have=0,n.mode=K2;case K2:for(;n.have<n.ncode;){for(;u<3;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}n.lens[Y[n.have++]]=l&7,l>>>=3,u-=3}for(;n.have<19;)n.lens[Y[n.have++]]=0;if(n.lencode=n.lendyn,n.lenbits=7,F={bits:n.lenbits},N=Ca(yR,n.lens,0,19,n.lencode,0,n.work,F),n.lenbits=F.bits,N){t.msg="invalid code lengths set",n.mode=ct;break}n.have=0,n.mode=J2;case J2:for(;n.have<n.nlen+n.ndist;){for(;v=n.lencode[l&(1<<n.lenbits)-1],y=v>>>24,A=v>>>16&255,S=v&65535,!(y<=u);){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(S<16)l>>>=y,u-=y,n.lens[n.have++]=S;else{if(S===16){for(C=y+2;u<C;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(l>>>=y,u-=y,n.have===0){t.msg="invalid bit length repeat",n.mode=ct;break}B=n.lens[n.have-1],h=3+(l&3),l>>>=2,u-=2}else if(S===17){for(C=y+3;u<C;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}l>>>=y,u-=y,B=0,h=3+(l&7),l>>>=3,u-=3}else{for(C=y+7;u<C;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}l>>>=y,u-=y,B=0,h=11+(l&127),l>>>=7,u-=7}if(n.have+h>n.nlen+n.ndist){t.msg="invalid bit length repeat",n.mode=ct;break}for(;h--;)n.lens[n.have++]=B}}if(n.mode===ct)break;if(n.lens[256]===0){t.msg="invalid code -- missing end-of-block",n.mode=ct;break}if(n.lenbits=9,F={bits:n.lenbits},N=Ca(F2,n.lens,0,n.nlen,n.lencode,0,n.work,F),n.lenbits=F.bits,N){t.msg="invalid literal/lengths set",n.mode=ct;break}if(n.distbits=6,n.distcode=n.distdyn,F={bits:n.distbits},N=Ca(M2,n.lens,n.nlen,n.ndist,n.distcode,0,n.work,F),n.distbits=F.bits,N){t.msg="invalid distances set",n.mode=ct;break}if(n.mode=ql,e===Gl)break e;case ql:n.mode=jl;case jl:if(a>=6&&c>=258){t.next_out=s,t.avail_out=c,t.next_in=i,t.avail_in=a,n.hold=l,n.bits=u,dR(t,d),s=t.next_out,o=t.output,c=t.avail_out,i=t.next_in,r=t.input,a=t.avail_in,l=n.hold,u=n.bits,n.mode===tr&&(n.back=-1);break}for(n.back=0;v=n.lencode[l&(1<<n.lenbits)-1],y=v>>>24,A=v>>>16&255,S=v&65535,!(y<=u);){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(A&&!(A&240)){for(E=y,I=A,_=S;v=n.lencode[_+((l&(1<<E+I)-1)>>E)],y=v>>>24,A=v>>>16&255,S=v&65535,!(E+y<=u);){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}l>>>=E,u-=E,n.back+=E}if(l>>>=y,u-=y,n.back+=y,n.length=S,A===0){n.mode=rw;break}if(A&32){n.back=-1,n.mode=tr;break}if(A&64){t.msg="invalid literal/length code",n.mode=ct;break}n.extra=A&15,n.mode=$2;case $2:if(n.extra){for(C=n.extra;u<C;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}n.length+=l&(1<<n.extra)-1,l>>>=n.extra,u-=n.extra,n.back+=n.extra}n.was=n.length,n.mode=ew;case ew:for(;v=n.distcode[l&(1<<n.distbits)-1],y=v>>>24,A=v>>>16&255,S=v&65535,!(y<=u);){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(!(A&240)){for(E=y,I=A,_=S;v=n.distcode[_+((l&(1<<E+I)-1)>>E)],y=v>>>24,A=v>>>16&255,S=v&65535,!(E+y<=u);){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}l>>>=E,u-=E,n.back+=E}if(l>>>=y,u-=y,n.back+=y,A&64){t.msg="invalid distance code",n.mode=ct;break}n.offset=S,n.extra=A&15,n.mode=tw;case 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650
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K=g.length;--K>=0;)g[K]=0}function ve(g){var K=g.state,$=K.pending;$>g.avail_out&&($=g.avail_out),$!==0&&(t.arraySet(g.output,K.pending_buf,K.pending_out,$,g.next_out),g.next_out+=$,K.pending_out+=$,g.total_out+=$,g.avail_out-=$,K.pending-=$,K.pending===0&&(K.pending_out=0))}function Ae(g,K){e._tr_flush_block(g,g.block_start>=0?g.block_start:-1,g.strstart-g.block_start,K),g.block_start=g.strstart,ve(g.strm)}function Re(g,K){g.pending_buf[g.pending++]=K}function dt(g,K){g.pending_buf[g.pending++]=K>>>8&255,g.pending_buf[g.pending++]=K&255}function $t(g,K,$,R){var H=g.avail_in;return H>R&&(H=R),H===0?0:(g.avail_in-=H,t.arraySet(K,g.input,g.next_in,H,$),g.state.wrap===1?g.adler=n(g.adler,K,H,$):g.state.wrap===2&&(g.adler=r(g.adler,K,H,$)),g.next_in+=H,g.total_in+=H,H)}function It(g,K){var 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ee;if(g.lookahead===0)break}if($=0,g.lookahead>=ce&&(g.ins_h=(g.ins_h<<g.hash_shift^g.window[g.strstart+ce-1])&g.hash_mask,$=g.prev[g.strstart&g.w_mask]=g.head[g.ins_h],g.head[g.ins_h]=g.strstart),g.prev_length=g.match_length,g.prev_match=g.match_start,g.match_length=ce-1,$!==0&&g.prev_length<g.max_lazy_match&&g.strstart-$<=g.w_size-he&&(g.match_length=It(g,$),g.match_length<=5&&(g.strategy===v||g.match_length===ce&&g.strstart-g.match_start>4096)&&(g.match_length=ce-1)),g.prev_length>=ce&&g.match_length<=g.prev_length){H=g.strstart+g.lookahead-ce,R=e._tr_tally(g,g.strstart-1-g.prev_match,g.prev_length-ce),g.lookahead-=g.prev_length-1,g.prev_length-=2;do++g.strstart<=H&&(g.ins_h=(g.ins_h<<g.hash_shift^g.window[g.strstart+ce-1])&g.hash_mask,$=g.prev[g.strstart&g.w_mask]=g.head[g.ins_h],g.head[g.ins_h]=g.strstart);while(--g.prev_length!==0);if(g.match_available=0,g.match_length=ce-1,g.strstart++,R&&(Ae(g,!1),g.strm.avail_out===0))return ee}else 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g.insert=0,K===c?(Ae(g,!0),g.strm.avail_out===0?fe:L):g.last_lit&&(Ae(g,!1),g.strm.avail_out===0)?ee:J}function m(g,K,$,R,H){this.good_length=g,this.max_lazy=K,this.nice_length=$,this.max_chain=R,this.func=H}var w;w=[new m(0,0,0,0,Rt),new m(4,4,8,4,Nt),new m(4,5,16,8,Nt),new m(4,6,32,32,Nt),new m(4,4,16,16,et),new m(8,16,32,32,et),new m(8,16,128,128,et),new m(8,32,128,256,et),new m(32,128,258,1024,et),new m(32,258,258,4096,et)];function O(g){g.window_size=2*g.w_size,Be(g.head),g.max_lazy_match=w[g.level].max_lazy,g.good_match=w[g.level].good_length,g.nice_match=w[g.level].nice_length,g.max_chain_length=w[g.level].max_chain,g.strstart=0,g.block_start=0,g.lookahead=0,g.insert=0,g.match_length=g.prev_length=ce-1,g.match_available=0,g.ins_h=0}function 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t.Buf16(2*Y+1),Be(this.depth),this.l_buf=0,this.lit_bufsize=0,this.last_lit=0,this.d_buf=0,this.opt_len=0,this.static_len=0,this.matches=0,this.insert=0,this.bi_buf=0,this.bi_valid=0}function z(g){var K;return!g||!g.state?te(g,d):(g.total_in=g.total_out=0,g.data_type=I,K=g.state,K.pending=0,K.pending_out=0,K.wrap<0&&(K.wrap=-K.wrap),K.status=K.wrap?we:q,g.adler=K.wrap===2?0:1,K.last_flush=i,e._tr_init(K),u)}function V(g){var K=z(g);return K===u&&O(g.state),K}function ue(g,K){return!g||!g.state||g.state.wrap!==2?d:(g.state.gzhead=K,u)}function G(g,K,$,R,H,Z){if(!g)return d;var Ce=1;if(K===b&&(K=6),R<0?(Ce=0,R=-R):R>15&&(Ce=2,R-=16),H<1||H>B||$!==_||R<8||R>15||K<0||K>9||Z<0||Z>S)return te(g,d);R===8&&(R=9);var me=new x;return g.state=me,me.strm=g,me.wrap=Ce,me.gzhead=null,me.w_bits=R,me.w_size=1<<me.w_bits,me.w_mask=me.w_size-1,me.hash_bits=H+7,me.hash_size=1<<me.hash_bits,me.hash_mask=me.hash_size-1,me.hash_shift=~~((me.hash_bits+ce-1)/ce),me.window=new t.Buf8(me.w_size*2),me.head=new t.Buf16(me.hash_size),me.prev=new t.Buf16(me.w_size),me.lit_bufsize=1<<H+6,me.pending_buf_size=me.lit_bufsize*4,me.pending_buf=new t.Buf8(me.pending_buf_size),me.d_buf=1*me.lit_bufsize,me.l_buf=3*me.lit_bufsize,me.level=K,me.strategy=Z,me.method=$,V(g)}function X(g,K){return G(g,K,_,N,F,E)}function T(g,K){var $,R,H,Z;if(!g||!g.state||K>l||K<0)return g?te(g,d):d;if(R=g.state,!g.output||!g.input&&g.avail_in!==0||R.status===j&&K!==c)return te(g,g.avail_out===0?p:d);if(R.strm=g,$=R.last_flush,R.last_flush=K,R.status===we)if(R.wrap===2)g.adler=0,Re(R,31),Re(R,139),Re(R,8),R.gzhead?(Re(R,(R.gzhead.text?1:0)+(R.gzhead.hcrc?2:0)+(R.gzhead.extra?4:0)+(R.gzhead.name?8:0)+(R.gzhead.comment?16:0)),Re(R,R.gzhead.time&255),Re(R,R.gzhead.time>>8&255),Re(R,R.gzhead.time>>16&255),Re(R,R.gzhead.time>>24&255),Re(R,R.level===9?2:R.strategy>=y||R.level<2?4:0),Re(R,R.gzhead.os&255),R.gzhead.extra&&R.gzhead.extra.length&&(Re(R,R.gzhead.extra.length&255),Re(R,R.gzhead.extra.length>>8&255)),R.gzhead.hcrc&&(g.adler=r(g.adler,R.pending_buf,R.pending,0)),R.gzindex=0,R.status=Ee):(Re(R,0),Re(R,0),Re(R,0),Re(R,0),Re(R,0),Re(R,R.level===9?2:R.strategy>=y||R.level<2?4:0),Re(R,D),R.status=q);else{var Ce=_+(R.w_bits-8<<4)<<8,me=-1;R.strategy>=y||R.level<2?me=0:R.level<6?me=1:R.level===6?me=2:me=3,Ce|=me<<6,R.strstart!==0&&(Ce|=De),Ce+=31-Ce%31,R.status=q,dt(R,Ce),R.strstart!==0&&(dt(R,g.adler>>>16),dt(R,g.adler&65535)),g.adler=1}if(R.status===Ee)if(R.gzhead.extra){for(H=R.pending;R.gzindex<(R.gzhead.extra.length&65535)&&!(R.pending===R.pending_buf_size&&(R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),ve(g),H=R.pending,R.pending===R.pending_buf_size));)Re(R,R.gzhead.extra[R.gzindex]&255),R.gzindex++;R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),R.gzindex===R.gzhead.extra.length&&(R.gzindex=0,R.status=Ie)}else R.status=Ie;if(R.status===Ie)if(R.gzhead.name){H=R.pending;do{if(R.pending===R.pending_buf_size&&(R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),ve(g),H=R.pending,R.pending===R.pending_buf_size)){Z=1;break}R.gzindex<R.gzhead.name.length?Z=R.gzhead.name.charCodeAt(R.gzindex++)&255:Z=0,Re(R,Z)}while(Z!==0);R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),Z===0&&(R.gzindex=0,R.status=Ge)}else R.status=Ge;if(R.status===Ge)if(R.gzhead.comment){H=R.pending;do{if(R.pending===R.pending_buf_size&&(R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),ve(g),H=R.pending,R.pending===R.pending_buf_size)){Z=1;break}R.gzindex<R.gzhead.comment.length?Z=R.gzhead.comment.charCodeAt(R.gzindex++)&255:Z=0,Re(R,Z)}while(Z!==0);R.gzhead.hcrc&&R.pending>H&&(g.adler=r(g.adler,R.pending_buf,R.pending-H,H)),Z===0&&(R.status=Ve)}else R.status=Ve;if(R.status===Ve&&(R.gzhead.hcrc?(R.pending+2>R.pending_buf_size&&ve(g),R.pending+2<=R.pending_buf_size&&(Re(R,g.adler&255),Re(R,g.adler>>8&255),g.adler=0,R.status=q)):R.status=q),R.pending!==0){if(ve(g),g.avail_out===0)return R.last_flush=-1,u}else if(g.avail_in===0&&le(K)<=le($)&&K!==c)return te(g,p);if(R.status===j&&g.avail_in!==0)return te(g,p);if(g.avail_in!==0||R.lookahead!==0||K!==i&&R.status!==j){var xe=R.strategy===y?k(R,K):R.strategy===A?zt(R,K):w[R.level].func(R,K);if((xe===fe||xe===L)&&(R.status=j),xe===ee||xe===fe)return g.avail_out===0&&(R.last_flush=-1),u;if(xe===J&&(K===s?e._tr_align(R):K!==l&&(e._tr_stored_block(R,0,0,!1),K===a&&(Be(R.head),R.lookahead===0&&(R.strstart=0,R.block_start=0,R.insert=0))),ve(g),g.avail_out===0))return R.last_flush=-1,u}return K!==c?u:R.wrap<=0?f:(R.wrap===2?(Re(R,g.adler&255),Re(R,g.adler>>8&255),Re(R,g.adler>>16&255),Re(R,g.adler>>24&255),Re(R,g.total_in&255),Re(R,g.total_in>>8&255),Re(R,g.total_in>>16&255),Re(R,g.total_in>>24&255)):(dt(R,g.adler>>>16),dt(R,g.adler&65535)),ve(g),R.wrap>0&&(R.wrap=-R.wrap),R.pending!==0?u:f)}function re(g){var K;return!g||!g.state?d:(K=g.state.status,K!==we&&K!==Ee&&K!==Ie&&K!==Ge&&K!==Ve&&K!==q&&K!==j?te(g,d):(g.state=null,K===q?te(g,h):u))}function _e(g,K){var $=K.length,R,H,Z,Ce,me,xe,Ue,bn;if(!g||!g.state||(R=g.state,Ce=R.wrap,Ce===2||Ce===1&&R.status!==we||R.lookahead))return d;for(Ce===1&&(g.adler=n(g.adler,K,$,0)),R.wrap=0,$>=R.w_size&&(Ce===0&&(Be(R.head),R.strstart=0,R.block_start=0,R.insert=0),bn=new t.Buf8(R.w_size),t.arraySet(bn,K,$-R.w_size,R.w_size,0),K=bn,$=R.w_size),me=g.avail_in,xe=g.next_in,Ue=g.input,g.avail_in=$,g.next_in=0,g.input=K,$e(R);R.lookahead>=ce;){H=R.strstart,Z=R.lookahead-(ce-1);do 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p(A);this.options=e.assign({level:f,method:h,chunkSize:16384,windowBits:15,memLevel:8,strategy:d,to:""},A||{});var S=this.options;S.raw&&S.windowBits>0?S.windowBits=-S.windowBits:S.gzip&&S.windowBits>0&&S.windowBits<16&&(S.windowBits+=16),this.err=0,this.msg="",this.ended=!1,this.chunks=[],this.strm=new o,this.strm.avail_out=0;var E=t.deflateInit2(this.strm,S.level,S.method,S.windowBits,S.memLevel,S.strategy);if(E!==c)throw new Error(r[E]);if(S.header&&t.deflateSetHeader(this.strm,S.header),S.dictionary){var I;if(typeof S.dictionary=="string"?I=n.string2buf(S.dictionary):i.call(S.dictionary)==="[object ArrayBuffer]"?I=new Uint8Array(S.dictionary):I=S.dictionary,E=t.deflateSetDictionary(this.strm,I),E!==c)throw new Error(r[E]);this._dict_set=!0}}p.prototype.push=function(A,S){var E=this.strm,I=this.options.chunkSize,_,B;if(this.ended)return!1;B=S===~~S?S:S===!0?a:s,typeof A=="string"?E.input=n.string2buf(A):i.call(A)==="[object ArrayBuffer]"?E.input=new Uint8Array(A):E.input=A,E.next_in=0,E.avail_in=E.input.length;do{if(E.avail_out===0&&(E.output=new e.Buf8(I),E.next_out=0,E.avail_out=I),_=t.deflate(E,B),_!==l&&_!==c)return this.onEnd(_),this.ended=!0,!1;(E.avail_out===0||E.avail_in===0&&(B===a||B===u))&&(this.options.to==="string"?this.onData(n.buf2binstring(e.shrinkBuf(E.output,E.next_out))):this.onData(e.shrinkBuf(E.output,E.next_out)))}while((E.avail_in>0||E.avail_out===0)&&_!==l);return B===a?(_=t.deflateEnd(this.strm),this.onEnd(_),this.ended=!0,_===c):(B===u&&(this.onEnd(c),E.avail_out=0),!0)},p.prototype.onData=function(A){this.chunks.push(A)},p.prototype.onEnd=function(A){A===c&&(this.options.to==="string"?this.result=this.chunks.join(""):this.result=e.flattenChunks(this.chunks)),this.chunks=[],this.err=A,this.msg=this.strm.msg};function b(A,S){var E=new p(S);if(E.push(A,!0),E.err)throw E.msg||r[E.err];return E.result}function v(A,S){return S=S||{},S.raw=!0,b(A,S)}function y(A,S){return S=S||{},S.gzip=!0,b(A,S)}return bo.Deflate=p,bo.deflate=b,bo.deflateRaw=v,bo.gzip=y,bo}var yo={},hn={},ad,c2;function C_(){if(c2)return ad;c2=1;var t=30,e=12;return ad=function(r,o){var i,s,a,c,l,u,f,d,h,p,b,v,y,A,S,E,I,_,B,N,F,M,C,Y,Q;i=r.state,s=r.next_in,Y=r.input,a=s+(r.avail_in-5),c=r.next_out,Q=r.output,l=c-(o-r.avail_out),u=c+(r.avail_out-257),f=i.dmax,d=i.wsize,h=i.whave,p=i.wnext,b=i.window,v=i.hold,y=i.bits,A=i.lencode,S=i.distcode,E=(1<<i.lenbits)-1,I=(1<<i.distbits)-1;e:do{y<15&&(v+=Y[s++]<<y,y+=8,v+=Y[s++]<<y,y+=8),_=A[v&E];t:for(;;){if(B=_>>>24,v>>>=B,y-=B,B=_>>>16&255,B===0)Q[c++]=_&65535;else if(B&16){N=_&65535,B&=15,B&&(y<B&&(v+=Y[s++]<<y,y+=8),N+=v&(1<<B)-1,v>>>=B,y-=B),y<15&&(v+=Y[s++]<<y,y+=8,v+=Y[s++]<<y,y+=8),_=S[v&I];n:for(;;){if(B=_>>>24,v>>>=B,y-=B,B=_>>>16&255,B&16){if(F=_&65535,B&=15,y<B&&(v+=Y[s++]<<y,y+=8,y<B&&(v+=Y[s++]<<y,y+=8)),F+=v&(1<<B)-1,F>f){r.msg="invalid distance too far back",i.mode=t;break e}if(v>>>=B,y-=B,B=c-l,F>B){if(B=F-B,B>h&&i.sane){r.msg="invalid distance too far 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t=Lr(),e=15,n=852,r=592,o=0,i=1,s=2,a=[3,4,5,6,7,8,9,10,11,13,15,17,19,23,27,31,35,43,51,59,67,83,99,115,131,163,195,227,258,0,0],c=[16,16,16,16,16,16,16,16,17,17,17,17,18,18,18,18,19,19,19,19,20,20,20,20,21,21,21,21,16,72,78],l=[1,2,3,4,5,7,9,13,17,25,33,49,65,97,129,193,257,385,513,769,1025,1537,2049,3073,4097,6145,8193,12289,16385,24577,0,0],u=[16,16,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,29,29,64,64];return cd=function(d,h,p,b,v,y,A,S){var E=S.bits,I=0,_=0,B=0,N=0,F=0,M=0,C=0,Y=0,Q=0,se=0,oe,ae,ce,ye,he,De=null,we=0,Ee,Ie=new t.Buf16(e+1),Ge=new t.Buf16(e+1),Ve=null,q=0,j,ee,J;for(I=0;I<=e;I++)Ie[I]=0;for(_=0;_<b;_++)Ie[h[p+_]]++;for(F=E,N=e;N>=1&&Ie[N]===0;N--);if(F>N&&(F=N),N===0)return 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t=Lr(),e=Jy(),n=e2(),r=C_(),o=I_(),i=0,s=1,a=2,c=4,l=5,u=6,f=0,d=1,h=2,p=-2,b=-3,v=-4,y=-5,A=8,S=1,E=2,I=3,_=4,B=5,N=6,F=7,M=8,C=9,Y=10,Q=11,se=12,oe=13,ae=14,ce=15,ye=16,he=17,De=18,we=19,Ee=20,Ie=21,Ge=22,Ve=23,q=24,j=25,ee=26,J=27,fe=28,L=29,D=30,te=31,le=32,Be=852,ve=592,Ae=15,Re=Ae;function dt(G){return(G>>>24&255)+(G>>>8&65280)+((G&65280)<<8)+((G&255)<<24)}function $t(){this.mode=0,this.last=!1,this.wrap=0,this.havedict=!1,this.flags=0,this.dmax=0,this.check=0,this.total=0,this.head=null,this.wbits=0,this.wsize=0,this.whave=0,this.wnext=0,this.window=null,this.hold=0,this.bits=0,this.length=0,this.offset=0,this.extra=0,this.lencode=null,this.distcode=null,this.lenbits=0,this.distbits=0,this.ncode=0,this.nlen=0,this.ndist=0,this.have=0,this.next=null,this.lens=new t.Buf16(320),this.work=new t.Buf16(288),this.lendyn=null,this.distdyn=null,this.sane=0,this.back=0,this.was=0}function It(G){var X;return!G||!G.state?p:(X=G.state,G.total_in=G.total_out=X.total=0,G.msg="",X.wrap&&(G.adler=X.wrap&1),X.mode=S,X.last=0,X.havedict=0,X.dmax=32768,X.head=null,X.hold=0,X.bits=0,X.lencode=X.lendyn=new t.Buf32(Be),X.distcode=X.distdyn=new t.Buf32(ve),X.sane=1,X.back=-1,f)}function $e(G){var X;return!G||!G.state?p:(X=G.state,X.wsize=0,X.whave=0,X.wnext=0,It(G))}function Rt(G,X){var T,re;return!G||!G.state||(re=G.state,X<0?(T=0,X=-X):(T=(X>>4)+1,X<48&&(X&=15)),X&&(X<8||X>15))?p:(re.window!==null&&re.wbits!==X&&(re.window=null),re.wrap=T,re.wbits=X,$e(G))}function Nt(G,X){var T,re;return G?(re=new $t,G.state=re,re.window=null,T=Rt(G,X),T!==f&&(G.state=null),T):p}function et(G){return Nt(G,Re)}var zt=!0,k,m;function w(G){if(zt){var X;for(k=new t.Buf32(512),m=new 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p;T=G.state,T.mode===se&&(T.mode=oe),K=G.next_out,_e=G.output,R=G.avail_out,g=G.next_in,re=G.input,$=G.avail_in,H=T.hold,Z=T.bits,Ce=$,me=R,Ne=f;e:for(;;)switch(T.mode){case S:if(T.wrap===0){T.mode=oe;break}for(;Z<16;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(T.wrap&2&&H===35615){T.check=0,ht[0]=H&255,ht[1]=H>>>8&255,T.check=n(T.check,ht,2,0),H=0,Z=0,T.mode=E;break}if(T.flags=0,T.head&&(T.head.done=!1),!(T.wrap&1)||(((H&255)<<8)+(H>>8))%31){G.msg="incorrect header check",T.mode=D;break}if((H&15)!==A){G.msg="unknown compression method",T.mode=D;break}if(H>>>=4,Z-=4,ft=(H&15)+8,T.wbits===0)T.wbits=ft;else if(ft>T.wbits){G.msg="invalid window size",T.mode=D;break}T.dmax=1<<ft,G.adler=T.check=1,T.mode=H&512?Y:se,H=0,Z=0;break;case E:for(;Z<16;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(T.flags=H,(T.flags&255)!==A){G.msg="unknown compression method",T.mode=D;break}if(T.flags&57344){G.msg="unknown header flags 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Array(T.head.extra_len)),t.arraySet(T.head.extra,re,g,xe,ft)),T.flags&512&&(T.check=n(T.check,re,xe,g)),$-=xe,g+=xe,T.length-=xe),T.length))break e;T.length=0,T.mode=F;case F:if(T.flags&2048){if($===0)break e;xe=0;do ft=re[g+xe++],T.head&&ft&&T.length<65536&&(T.head.name+=String.fromCharCode(ft));while(ft&&xe<$);if(T.flags&512&&(T.check=n(T.check,re,xe,g)),$-=xe,g+=xe,ft)break e}else T.head&&(T.head.name=null);T.length=0,T.mode=M;case M:if(T.flags&4096){if($===0)break e;xe=0;do ft=re[g+xe++],T.head&&ft&&T.length<65536&&(T.head.comment+=String.fromCharCode(ft));while(ft&&xe<$);if(T.flags&512&&(T.check=n(T.check,re,xe,g)),$-=xe,g+=xe,ft)break e}else T.head&&(T.head.comment=null);T.mode=C;case C:if(T.flags&512){for(;Z<16;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(H!==(T.check&65535)){G.msg="header crc mismatch",T.mode=D;break}H=0,Z=0}T.head&&(T.head.hcrc=T.flags>>9&1,T.head.done=!0),G.adler=T.check=0,T.mode=se;break;case Y:for(;Z<32;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}G.adler=T.check=dt(H),H=0,Z=0,T.mode=Q;case Q:if(T.havedict===0)return G.next_out=K,G.avail_out=R,G.next_in=g,G.avail_in=$,T.hold=H,T.bits=Z,h;G.adler=T.check=1,T.mode=se;case se:if(X===l||X===u)break e;case oe:if(T.last){H>>>=Z&7,Z-=Z&7,T.mode=J;break}for(;Z<3;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}switch(T.last=H&1,H>>>=1,Z-=1,H&3){case 0:T.mode=ae;break;case 1:if(w(T),T.mode=Ee,X===u){H>>>=2,Z-=2;break e}break;case 2:T.mode=he;break;case 3:G.msg="invalid block type",T.mode=D}H>>>=2,Z-=2;break;case ae:for(H>>>=Z&7,Z-=Z&7;Z<32;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if((H&65535)!==(H>>>16^65535)){G.msg="invalid stored block lengths",T.mode=D;break}if(T.length=H&65535,H=0,Z=0,T.mode=ce,X===u)break e;case ce:T.mode=ye;case ye:if(xe=T.length,xe){if(xe>$&&(xe=$),xe>R&&(xe=R),xe===0)break e;t.arraySet(_e,re,g,xe,K),$-=xe,g+=xe,R-=xe,K+=xe,T.length-=xe;break}T.mode=se;break;case he:for(;Z<14;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(T.nlen=(H&31)+257,H>>>=5,Z-=5,T.ndist=(H&31)+1,H>>>=5,Z-=5,T.ncode=(H&15)+4,H>>>=4,Z-=4,T.nlen>286||T.ndist>30){G.msg="too many length or distance symbols",T.mode=D;break}T.have=0,T.mode=De;case De:for(;T.have<T.ncode;){for(;Z<3;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}T.lens[$a[T.have++]]=H&7,H>>>=3,Z-=3}for(;T.have<19;)T.lens[$a[T.have++]]=0;if(T.lencode=T.lendyn,T.lenbits=7,Bn={bits:T.lenbits},Ne=o(i,T.lens,0,19,T.lencode,0,T.work,Bn),T.lenbits=Bn.bits,Ne){G.msg="invalid code lengths set",T.mode=D;break}T.have=0,T.mode=we;case we:for(;T.have<T.nlen+T.ndist;){for(;U=T.lencode[H&(1<<T.lenbits)-1],Me=U>>>24,lt=U>>>16&255,tt=U&65535,!(Me<=Z);){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(tt<16)H>>>=Me,Z-=Me,T.lens[T.have++]=tt;else{if(tt===16){for(on=Me+2;Z<on;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}if(H>>>=Me,Z-=Me,T.have===0){G.msg="invalid bit length repeat",T.mode=D;break}ft=T.lens[T.have-1],xe=3+(H&3),H>>>=2,Z-=2}else if(tt===17){for(on=Me+3;Z<on;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}H>>>=Me,Z-=Me,ft=0,xe=3+(H&7),H>>>=3,Z-=3}else{for(on=Me+7;Z<on;){if($===0)break e;$--,H+=re[g++]<<Z,Z+=8}H>>>=Me,Z-=Me,ft=0,xe=11+(H&127),H>>>=7,Z-=7}if(T.have+xe>T.nlen+T.ndist){G.msg="invalid bit length repeat",T.mode=D;break}for(;xe--;)T.lens[T.have++]=ft}}if(T.mode===D)break;if(T.lens[256]===0){G.msg="invalid code -- missing end-of-block",T.mode=D;break}if(T.lenbits=9,Bn={bits:T.lenbits},Ne=o(s,T.lens,0,T.nlen,T.lencode,0,T.work,Bn),T.lenbits=Bn.bits,Ne){G.msg="invalid literal/lengths set",T.mode=D;break}if(T.distbits=6,T.distcode=T.distdyn,Bn={bits:T.distbits},Ne=o(a,T.lens,T.nlen,T.ndist,T.distcode,0,T.work,Bn),T.distbits=Bn.bits,Ne){G.msg="invalid distances set",T.mode=D;break}if(T.mode=Ee,X===u)break e;case Ee:T.mode=Ie;case 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this.onEnd(v),this.ended=!0,!1;h.next_out&&(h.avail_out===0||v===r.Z_STREAM_END||h.avail_in===0&&(y===r.Z_FINISH||y===r.Z_SYNC_FLUSH))&&(this.options.to==="string"?(A=n.utf8border(h.output,h.next_out),S=h.next_out-A,E=n.buf2string(h.output,A),h.next_out=S,h.avail_out=p-S,S&&e.arraySet(h.output,h.output,A,S,0),this.onData(E)):this.onData(e.shrinkBuf(h.output,h.next_out))),h.avail_in===0&&h.avail_out===0&&(I=!0)}while((h.avail_in>0||h.avail_out===0)&&v!==r.Z_STREAM_END);return v===r.Z_STREAM_END&&(y=r.Z_FINISH),y===r.Z_FINISH?(v=t.inflateEnd(this.strm),this.onEnd(v),this.ended=!0,v===r.Z_OK):(y===r.Z_SYNC_FLUSH&&(this.onEnd(r.Z_OK),h.avail_out=0),!0)},c.prototype.onData=function(f){this.chunks.push(f)},c.prototype.onEnd=function(f){f===r.Z_OK&&(this.options.to==="string"?this.result=this.chunks.join(""):this.result=e.flattenChunks(this.chunks)),this.chunks=[],this.err=f,this.msg=this.strm.msg};function l(f,d){var h=new c(d);if(h.push(f,!0),h.err)throw h.msg||o[h.err];return h.result}function u(f,d){return d=d||{},d.raw=!0,l(f,d)}return yo.Inflate=c,yo.inflate=l,yo.inflateRaw=u,yo.ungzip=l,yo}var fd,g2;function k_(){if(g2)return fd;g2=1;var t=Lr().assign,e=S_(),n=B_(),r=h2(),o={};return t(o,e,n,r),fd=o,fd}var Ll=k_();async function Or(t){try{let e,n=0,r=0;const o=[];let i=0,s;do{const c=t.subarray(n);if(s=new Ll.Inflate,{strm:e}=s,s.push(c,Ll.Z_SYNC_FLUSH),s.err)throw new Error(s.msg);n+=e.next_in,o[r]=s.result,i+=o[r].length,r+=1}while(e.avail_in);const a=new Uint8Array(i);for(let c=0,l=0;c<o.length;c++)a.set(o[c],l),l+=o[c].length;return Ke.Buffer.from(a)}catch(e){throw/incorrect header check/.exec(`${e}`)?new Error("problem decompressing block: incorrect gzip header check"):e}}async function m2(t,e){try{let n;const{minv:r,maxv:o}=e;let i=r.blockPosition,s=r.dataPosition;const a=[],c=[],l=[];let u=0,f=0;do{const p=t.subarray(i-r.blockPosition),b=new Ll.Inflate;if({strm:n}=b,b.push(p,Ll.Z_SYNC_FLUSH),b.err)throw new Error(b.msg);const v=b.result;a.push(v);let y=v.length;c.push(i),l.push(s),a.length===1&&r.dataPosition&&(a[0]=a[0].subarray(r.dataPosition),y=a[0].length);const A=i;if(i+=n.next_in,s+=y,A>=o.blockPosition){a[f]=a[f].subarray(0,o.blockPosition===r.blockPosition?o.dataPosition-r.dataPosition+1:o.dataPosition+1),c.push(i),l.push(s),u+=a[f].length;break}u+=a[f].length,f++}while(n.avail_in);const d=new Uint8Array(u);for(let p=0,b=0;p<a.length;p++)d.set(a[p],b),b+=a[p].length;return{buffer:Ke.Buffer.from(d),cpositions:c,dpositions:l}}catch(n){throw/incorrect header check/.exec(`${n}`)?new Error("problem decompressing block: incorrect gzip header check"):n}}var hd,b2;function __(){if(b2)return hd;b2=1,hd=e;var t=null;try{t=new WebAssembly.Instance(new WebAssembly.Module(new Uint8Array([0,97,115,109,1,0,0,0,1,13,2,96,0,1,127,96,4,127,127,127,127,1,127,3,7,6,0,1,1,1,1,1,6,6,1,127,1,65,0,11,7,50,6,3,109,117,108,0,1,5,100,105,118,95,115,0,2,5,100,105,118,95,117,0,3,5,114,101,109,95,115,0,4,5,114,101,109,95,117,0,5,8,103,101,116,95,104,105,103,104,0,0,10,191,1,6,4,0,35,0,11,36,1,1,126,32,0,173,32,1,173,66,32,134,132,32,2,173,32,3,173,66,32,134,132,126,34,4,66,32,135,167,36,0,32,4,167,11,36,1,1,126,32,0,173,32,1,173,66,32,134,132,32,2,173,32,3,173,66,32,134,132,127,34,4,66,32,135,167,36,0,32,4,167,11,36,1,1,126,32,0,173,32,1,173,66,32,134,132,32,2,173,32,3,173,66,32,134,132,128,34,4,66,32,135,167,36,0,32,4,167,11,36,1,1,126,32,0,173,32,1,173,66,32,134,132,32,2,173,32,3,173,66,32,134,132,129,34,4,66,32,135,167,36,0,32,4,167,11,36,1,1,126,32,0,173,32,1,173,66,32,134,132,32,2,173,32,3,173,66,32,134,132,130,34,4,66,32,135,167,36,0,32,4,167,11])),{}).exports}catch{}function e(M,C,Y){this.low=M|0,this.high=C|0,this.unsigned=!!Y}e.prototype.__isLong__,Object.defineProperty(e.prototype,"__isLong__",{value:!0});function n(M){return(M&&M.__isLong__)===!0}e.isLong=n;var r={},o={};function i(M,C){var Y,Q,se;return C?(M>>>=0,(se=0<=M&&M<256)&&(Q=o[M],Q)?Q:(Y=a(M,(M|0)<0?-1:0,!0),se&&(o[M]=Y),Y)):(M|=0,(se=-128<=M&&M<128)&&(Q=r[M],Q)?Q:(Y=a(M,M<0?-1:0,!1),se&&(r[M]=Y),Y))}e.fromInt=i;function s(M,C){if(isNaN(M))return C?A:y;if(C){if(M<0)return A;if(M>=p)return B}else{if(M<=-9223372036854776e3)return N;if(M+1>=b)return _}return M<0?s(-M,C).neg():a(M%h|0,M/h|0,C)}e.fromNumber=s;function a(M,C,Y){return new e(M,C,Y)}e.fromBits=a;var c=Math.pow;function l(M,C,Y){if(M.length===0)throw Error("empty string");if(M==="NaN"||M==="Infinity"||M==="+Infinity"||M==="-Infinity")return y;if(typeof C=="number"?(Y=C,C=!1):C=!!C,Y=Y||10,Y<2||36<Y)throw RangeError("radix");var Q;if((Q=M.indexOf("-"))>0)throw Error("interior hyphen");if(Q===0)return l(M.substring(1),C,Y).neg();for(var se=s(c(Y,8)),oe=y,ae=0;ae<M.length;ae+=8){var ce=Math.min(8,M.length-ae),ye=parseInt(M.substring(ae,ae+ce),Y);if(ce<8){var he=s(c(Y,ce));oe=oe.mul(he).add(s(ye))}else oe=oe.mul(se),oe=oe.add(s(ye))}return oe.unsigned=C,oe}e.fromString=l;function u(M,C){return typeof M=="number"?s(M,C):typeof M=="string"?l(M,C):a(M.low,M.high,typeof C=="boolean"?C:M.unsigned)}e.fromValue=u;var f=65536,d=1<<24,h=f*f,p=h*h,b=p/2,v=i(d),y=i(0);e.ZERO=y;var A=i(0,!0);e.UZERO=A;var S=i(1);e.ONE=S;var E=i(1,!0);e.UONE=E;var I=i(-1);e.NEG_ONE=I;var _=a(-1,2147483647,!1);e.MAX_VALUE=_;var B=a(-1,-1,!0);e.MAX_UNSIGNED_VALUE=B;var N=a(0,-2147483648,!1);e.MIN_VALUE=N;var F=e.prototype;return F.toInt=function(){return this.unsigned?this.low>>>0:this.low},F.toNumber=function(){return this.unsigned?(this.high>>>0)*h+(this.low>>>0):this.high*h+(this.low>>>0)},F.toString=function(C){if(C=C||10,C<2||36<C)throw RangeError("radix");if(this.isZero())return"0";if(this.isNegative())if(this.eq(N)){var Y=s(C),Q=this.div(Y),se=Q.mul(Y).sub(this);return Q.toString(C)+se.toInt().toString(C)}else return"-"+this.neg().toString(C);for(var oe=s(c(C,6),this.unsigned),ae=this,ce="";;){var ye=ae.div(oe),he=ae.sub(ye.mul(oe)).toInt()>>>0,De=he.toString(C);if(ae=ye,ae.isZero())return De+ce;for(;De.length<6;)De="0"+De;ce=""+De+ce}},F.getHighBits=function(){return this.high},F.getHighBitsUnsigned=function(){return this.high>>>0},F.getLowBits=function(){return this.low},F.getLowBitsUnsigned=function(){return this.low>>>0},F.getNumBitsAbs=function(){if(this.isNegative())return this.eq(N)?64:this.neg().getNumBitsAbs();for(var C=this.high!=0?this.high:this.low,Y=31;Y>0&&!(C&1<<Y);Y--);return this.high!=0?Y+33:Y+1},F.isZero=function(){return this.high===0&&this.low===0},F.eqz=F.isZero,F.isNegative=function(){return!this.unsigned&&this.high<0},F.isPositive=function(){return this.unsigned||this.high>=0},F.isOdd=function(){return(this.low&1)===1},F.isEven=function(){return(this.low&1)===0},F.equals=function(C){return n(C)||(C=u(C)),this.unsigned!==C.unsigned&&this.high>>>31===1&&C.high>>>31===1?!1:this.high===C.high&&this.low===C.low},F.eq=F.equals,F.notEquals=function(C){return!this.eq(C)},F.neq=F.notEquals,F.ne=F.notEquals,F.lessThan=function(C){return this.comp(C)<0},F.lt=F.lessThan,F.lessThanOrEqual=function(C){return this.comp(C)<=0},F.lte=F.lessThanOrEqual,F.le=F.lessThanOrEqual,F.greaterThan=function(C){return this.comp(C)>0},F.gt=F.greaterThan,F.greaterThanOrEqual=function(C){return this.comp(C)>=0},F.gte=F.greaterThanOrEqual,F.ge=F.greaterThanOrEqual,F.compare=function(C){if(n(C)||(C=u(C)),this.eq(C))return 0;var Y=this.isNegative(),Q=C.isNegative();return 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C.isNegative()?this.neg().mul(C.neg()):this.neg().mul(C).neg();if(C.isNegative())return this.mul(C.neg()).neg();if(this.lt(v)&&C.lt(v))return s(this.toNumber()*C.toNumber(),this.unsigned);var Q=this.high>>>16,se=this.high&65535,oe=this.low>>>16,ae=this.low&65535,ce=C.high>>>16,ye=C.high&65535,he=C.low>>>16,De=C.low&65535,we=0,Ee=0,Ie=0,Ge=0;return Ge+=ae*De,Ie+=Ge>>>16,Ge&=65535,Ie+=oe*De,Ee+=Ie>>>16,Ie&=65535,Ie+=ae*he,Ee+=Ie>>>16,Ie&=65535,Ee+=se*De,we+=Ee>>>16,Ee&=65535,Ee+=oe*he,we+=Ee>>>16,Ee&=65535,Ee+=ae*ye,we+=Ee>>>16,Ee&=65535,we+=Q*De+se*he+oe*ye+ae*ce,we&=65535,a(Ie<<16|Ge,we<<16|Ee,this.unsigned)},F.mul=F.multiply,F.divide=function(C){if(n(C)||(C=u(C)),C.isZero())throw Error("division by zero");if(t){if(!this.unsigned&&this.high===-2147483648&&C.low===-1&&C.high===-1)return this;var Y=(this.unsigned?t.div_u:t.div_s)(this.low,this.high,C.low,C.high);return a(Y,t.get_high(),this.unsigned)}if(this.isZero())return this.unsigned?A:y;var 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this.sub(this.div(C).mul(C))},F.mod=F.modulo,F.rem=F.modulo,F.not=function(){return a(~this.low,~this.high,this.unsigned)},F.and=function(C){return n(C)||(C=u(C)),a(this.low&C.low,this.high&C.high,this.unsigned)},F.or=function(C){return n(C)||(C=u(C)),a(this.low|C.low,this.high|C.high,this.unsigned)},F.xor=function(C){return n(C)||(C=u(C)),a(this.low^C.low,this.high^C.high,this.unsigned)},F.shiftLeft=function(C){return n(C)&&(C=C.toInt()),(C&=63)===0?this:C<32?a(this.low<<C,this.high<<C|this.low>>>32-C,this.unsigned):a(0,this.low<<C-32,this.unsigned)},F.shl=F.shiftLeft,F.shiftRight=function(C){return n(C)&&(C=C.toInt()),(C&=63)===0?this:C<32?a(this.low>>>C|this.high<<32-C,this.high>>C,this.unsigned):a(this.high>>C-32,this.high>=0?0:-1,this.unsigned)},F.shr=F.shiftRight,F.shiftRightUnsigned=function(C){if(n(C)&&(C=C.toInt()),C&=63,C===0)return this;var Y=this.high;if(C<32){var Q=this.low;return a(Q>>>C|Y<<32-C,Y>>>C,this.unsigned)}else return 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o=await this._getIndex(),i=[],s=(d,h)=>{const p=d[Nl],b=h?h[Nl]:1/0;return p<=n&&b>n?0:p<n?-1:1};let a=0,c=o.length-1,l=Math.floor(o.length/2),u=s(o[l],o[l+1]);for(;u!==0;)u>0?c=l-1:u<0&&(a=l+1),l=Math.ceil((c-a)/2)+a,u=s(o[l],o[l+1]);i.push(o[l]);let f=l+1;for(;f<o.length&&(i.push(o[f]),!(o[f][Nl]>=r));f+=1);return i[i.length-1][Nl]<r&&i.push([]),i}}class y2{constructor({filehandle:e,path:n,gziFilehandle:r,gziPath:o}){if(e)this.filehandle=e;else if(n)this.filehandle=new Ct(n);else throw new TypeError("either filehandle or path must be defined");if(!r&&!o&&!n)throw new TypeError("either gziFilehandle or gziPath must be defined");this.gzi=new F_({filehandle:r,path:!r&&!o&&n?o:`${n}.gzi`})}async stat(){const e=await this.filehandle.stat();return Object.assign(e,{size:await this.getUncompressedFileSize(),blocks:void 0,blksize:void 0})}async getUncompressedFileSize(){const[,e]=await this.gzi.getLastBlock(),{size:n}=await this.filehandle.stat(),r=Ke.Buffer.allocUnsafe(4),{bytesRead:o}=await 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")).filter(s=>s[0]!=="").map(s=>((!o||o.name!==s[0])&&(o={name:s[0],id:r},r+=1),{id:o.id,name:s[0],length:+s[1],start:0,end:+s[1],offset:+s[2],lineLength:+s[3],lineBytes:+s[4]}));return{name:Object.fromEntries(i.map(s=>[s.name,s])),id:Object.fromEntries(i.map(s=>[s.id,s]))}}class x2{constructor({fasta:e,fai:n,path:r,faiPath:o}){if(e)this.fasta=e;else if(r)this.fasta=new Ct(r);else throw new Error("Need to pass filehandle for fasta or path to localfile");if(n)this.fai=n;else if(o)this.fai=new Ct(o);else if(r)this.fai=new Ct(`${r}.fai`);else throw new Error("Need to pass filehandle for or path to localfile")}async _getIndexes(e){return this.indexes||(this.indexes=M_(this.fai,e)),this.indexes}async getSequenceNames(e){return Object.keys((await this._getIndexes(e)).name)}async getSequenceSizes(e){const n={},r=await this._getIndexes(e);for(const o of Object.values(r.id))n[o.name]=o.length;return n}async getSequenceSize(e,n){var r;return(r=(await 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t.split(">").filter(e=>/\S/.test(e)).map(e=>{const[n,...r]=e.split(`
|
|
651
|
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`),[o,...i]=n.split(" "),s=r.join("").replace(/\s/g,"");return{id:o,description:i.join(" "),sequence:s}})}class L_{constructor({fasta:e,path:n}){if(e)this.fasta=e;else if(n)this.fasta=new Ct(n);else throw new Error("Need to pass fasta or path");this.data=this.fasta.readFile().then(r=>{const o=r.toString("utf8");return v2(o)})}async fetch(e,n,r){const i=(await this.data).find(a=>a.id===e),s=r-n;if(!i)throw new Error(`no sequence with id ${e} exists`);return i.sequence.slice(n,s)}async getSequenceNames(){return(await this.data).map(n=>n.id)}}const O_=Object.freeze(Object.defineProperty({__proto__:null,BgzipIndexedFasta:P_,FetchableSmallFasta:L_,IndexedFasta:x2,parseSmallFasta:v2},Symbol.toStringTag,{value:"Module"})),A2=BigInt(32);function N_(t,e,n){const r=+!!n,o=+!n;return BigInt(t.getInt32(e,n)*o+t.getInt32(e+4,n)*r)<<A2|BigInt(t.getUint32(e,n)*r+t.getUint32(e+4,n)*o)}function z_(t,e,n){const r=t.getUint32(e,n),o=t.getUint32(e+4,n),i=+!!n,s=+!n;return 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Uint8Array(a),i=0,o=0;i<a;o++)n=t.charCodeAt(o),(n&64512)===55296&&o+1<s&&(r=t.charCodeAt(o+1),(r&64512)===56320&&(n=65536+(n-55296<<10)+(r-56320),o++)),n<128?e[i++]=n:n<2048?(e[i++]=192|n>>>6,e[i++]=128|n&63):n<65536?(e[i++]=224|n>>>12,e[i++]=128|n>>>6&63,e[i++]=128|n&63):(e[i++]=240|n>>>18,e[i++]=128|n>>>12&63,e[i++]=128|n>>>6&63,e[i++]=128|n&63);return e};const aR=(t,e)=>{if(e<65534&&t.subarray&&D2)return String.fromCharCode.apply(null,t.length===e?t:t.subarray(0,e));let n="";for(let r=0;r<e;r++)n+=String.fromCharCode(t[r]);return n};var cR=(t,e)=>{const n=e||t.length;if(typeof TextDecoder=="function"&&TextDecoder.prototype.decode)return new TextDecoder().decode(t.subarray(0,e));let r,o;const i=new Array(n*2);for(o=0,r=0;r<n;){let s=t[r++];if(s<128){i[o++]=s;continue}let a=Sa[s];if(a>4){i[o++]=65533,r+=a-1;continue}for(s&=a===2?31:a===3?15:7;a>1&&r<n;)s=s<<6|t[r++]&63,a--;if(a>1){i[o++]=65533;continue}s<65536?i[o++]=s:(s-=65536,i[o++]=55296|s>>10&1023,i[o++]=56320|s&1023)}return aR(i,o)},lR=(t,e)=>{e=e||t.length,e>t.length&&(e=t.length);let n=e-1;for(;n>=0&&(t[n]&192)===128;)n--;return n<0||n===0?e:n+Sa[t[n]]>e?n:e},md={string2buf:sR,buf2string:cR,utf8border:lR};function uR(){this.input=null,this.next_in=0,this.avail_in=0,this.total_in=0,this.output=null,this.next_out=0,this.avail_out=0,this.total_out=0,this.msg="",this.state=null,this.data_type=2,this.adler=0}var fR=uR;const Ul=16209,hR=16191;var dR=function(e,n){let r,o,i,s,a,c,l,u,f,d,h,p,b,v,y,A,S,E,I,_,B,N,F,M;const C=e.state;r=e.next_in,F=e.input,o=r+(e.avail_in-5),i=e.next_out,M=e.output,s=i-(n-e.avail_out),a=i+(e.avail_out-257),c=C.dmax,l=C.wsize,u=C.whave,f=C.wnext,d=C.window,h=C.hold,p=C.bits,b=C.lencode,v=C.distcode,y=(1<<C.lenbits)-1,A=(1<<C.distbits)-1;e:do{p<15&&(h+=F[r++]<<p,p+=8,h+=F[r++]<<p,p+=8),S=b[h&y];t:for(;;){if(E=S>>>24,h>>>=E,p-=E,E=S>>>16&255,E===0)M[i++]=S&65535;else if(E&16){I=S&65535,E&=15,E&&(p<E&&(h+=F[r++]<<p,p+=8),I+=h&(1<<E)-1,h>>>=E,p-=E),p<15&&(h+=F[r++]<<p,p+=8,h+=F[r++]<<p,p+=8),S=v[h&A];n:for(;;){if(E=S>>>24,h>>>=E,p-=E,E=S>>>16&255,E&16){if(_=S&65535,E&=15,p<E&&(h+=F[r++]<<p,p+=8,p<E&&(h+=F[r++]<<p,p+=8)),_+=h&(1<<E)-1,_>c){e.msg="invalid distance too far back",C.mode=Ul;break e}if(h>>>=E,p-=E,E=i-s,_>E){if(E=_-E,E>u&&C.sane){e.msg="invalid distance too far back",C.mode=Ul;break e}if(B=0,N=d,f===0){if(B+=l-E,E<I){I-=E;do M[i++]=d[B++];while(--E);B=i-_,N=M}}else if(f<E){if(B+=l+f-E,E-=f,E<I){I-=E;do M[i++]=d[B++];while(--E);if(B=0,f<I){E=f,I-=E;do M[i++]=d[B++];while(--E);B=i-_,N=M}}}else if(B+=f-E,E<I){I-=E;do M[i++]=d[B++];while(--E);B=i-_,N=M}for(;I>2;)M[i++]=N[B++],M[i++]=N[B++],M[i++]=N[B++],I-=3;I&&(M[i++]=N[B++],I>1&&(M[i++]=N[B++]))}else{B=i-_;do M[i++]=M[B++],M[i++]=M[B++],M[i++]=M[B++],I-=3;while(I>2);I&&(M[i++]=M[B++],I>1&&(M[i++]=M[B++]))}}else if(E&64){e.msg="invalid distance code",C.mode=Ul;break e}else{S=v[(S&65535)+(h&(1<<E)-1)];continue n}break}}else if(E&64)if(E&32){C.mode=hR;break e}else{e.msg="invalid literal/length code",C.mode=Ul;break e}else{S=b[(S&65535)+(h&(1<<E)-1)];continue t}break}}while(r<o&&i<a);I=p>>3,r-=I,p-=I<<3,h&=(1<<p)-1,e.next_in=r,e.next_out=i,e.avail_in=r<o?5+(o-r):5-(r-o),e.avail_out=i<a?257+(a-i):257-(i-a),C.hold=h,C.bits=p};const vo=15,B2=852,k2=592,_2=0,bd=1,R2=2,pR=new Uint16Array([3,4,5,6,7,8,9,10,11,13,15,17,19,23,27,31,35,43,51,59,67,83,99,115,131,163,195,227,258,0,0]),gR=new Uint8Array([16,16,16,16,16,16,16,16,17,17,17,17,18,18,18,18,19,19,19,19,20,20,20,20,21,21,21,21,16,72,78]),mR=new Uint16Array([1,2,3,4,5,7,9,13,17,25,33,49,65,97,129,193,257,385,513,769,1025,1537,2049,3073,4097,6145,8193,12289,16385,24577,0,0]),bR=new Uint8Array([16,16,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,28,28,29,29,64,64]);var Ca=(t,e,n,r,o,i,s,a)=>{const c=a.bits;let l=0,u=0,f=0,d=0,h=0,p=0,b=0,v=0,y=0,A=0,S,E,I,_,B,N=null,F;const M=new Uint16Array(vo+1),C=new Uint16Array(vo+1);let Y=null,Q,se,oe;for(l=0;l<=vo;l++)M[l]=0;for(u=0;u<r;u++)M[e[n+u]]++;for(h=c,d=vo;d>=1&&M[d]===0;d--);if(h>d&&(h=d),d===0)return o[i++]=1<<24|64<<16|0,o[i++]=1<<24|64<<16|0,a.bits=1,0;for(f=1;f<d&&M[f]===0;f++);for(h<f&&(h=f),v=1,l=1;l<=vo;l++)if(v<<=1,v-=M[l],v<0)return-1;if(v>0&&(t===_2||d!==1))return-1;for(C[1]=0,l=1;l<vo;l++)C[l+1]=C[l]+M[l];for(u=0;u<r;u++)e[n+u]!==0&&(s[C[e[n+u]]++]=u);if(t===_2?(N=Y=s,F=20):t===bd?(N=pR,Y=gR,F=257):(N=mR,Y=bR,F=0),A=0,u=0,l=f,B=i,p=h,b=0,I=-1,y=1<<h,_=y-1,t===bd&&y>B2||t===R2&&y>k2)return 1;for(;;){Q=l-b,s[u]+1<F?(se=0,oe=s[u]):s[u]>=F?(se=Y[s[u]-F],oe=N[s[u]-F]):(se=96,oe=0),S=1<<l-b,E=1<<p,f=E;do E-=S,o[B+(A>>b)+E]=Q<<24|se<<16|oe|0;while(E!==0);for(S=1<<l-1;A&S;)S>>=1;if(S!==0?(A&=S-1,A+=S):A=0,u++,--M[l]===0){if(l===d)break;l=e[n+s[u]]}if(l>h&&(A&_)!==I){for(b===0&&(b=h),B+=f,p=l-b,v=1<<p;p+b<d&&(v-=M[p+b],!(v<=0));)p++,v<<=1;if(y+=1<<p,t===bd&&y>B2||t===R2&&y>k2)return 1;I=A&_,o[I]=h<<24|p<<16|B-i|0}}return A!==0&&(o[B+A]=l-b<<24|64<<16|0),a.bits=h,0};const yR=0,F2=1,M2=2,{Z_FINISH:P2,Z_BLOCK:wR,Z_TREES:Gl,Z_OK:Si,Z_STREAM_END:xR,Z_NEED_DICT:vR,Z_STREAM_ERROR:dn,Z_DATA_ERROR:L2,Z_MEM_ERROR:O2,Z_BUF_ERROR:AR,Z_DEFLATED:N2}=I2,Hl=16180,z2=16181,U2=16182,G2=16183,H2=16184,V2=16185,q2=16186,j2=16187,W2=16188,Y2=16189,Vl=16190,tr=16191,yd=16192,Q2=16193,wd=16194,Z2=16195,X2=16196,K2=16197,J2=16198,ql=16199,jl=16200,$2=16201,ew=16202,tw=16203,nw=16204,rw=16205,xd=16206,iw=16207,ow=16208,ct=16209,sw=16210,aw=16211,ER=852,SR=592,CR=15,cw=t=>(t>>>24&255)+(t>>>8&65280)+((t&65280)<<8)+((t&255)<<24);function IR(){this.strm=null,this.mode=0,this.last=!1,this.wrap=0,this.havedict=!1,this.flags=0,this.dmax=0,this.check=0,this.total=0,this.head=null,this.wbits=0,this.wsize=0,this.whave=0,this.wnext=0,this.window=null,this.hold=0,this.bits=0,this.length=0,this.offset=0,this.extra=0,this.lencode=null,this.distcode=null,this.lenbits=0,this.distbits=0,this.ncode=0,this.nlen=0,this.ndist=0,this.have=0,this.next=null,this.lens=new Uint16Array(320),this.work=new Uint16Array(288),this.lendyn=null,this.distdyn=null,this.sane=0,this.back=0,this.was=0}const Ci=t=>{if(!t)return 1;const e=t.state;return!e||e.strm!==t||e.mode<Hl||e.mode>aw?1:0},lw=t=>{if(Ci(t))return dn;const e=t.state;return t.total_in=t.total_out=e.total=0,t.msg="",e.wrap&&(t.adler=e.wrap&1),e.mode=Hl,e.last=0,e.havedict=0,e.flags=-1,e.dmax=32768,e.head=null,e.hold=0,e.bits=0,e.lencode=e.lendyn=new Int32Array(ER),e.distcode=e.distdyn=new Int32Array(SR),e.sane=1,e.back=-1,Si},uw=t=>{if(Ci(t))return dn;const e=t.state;return e.wsize=0,e.whave=0,e.wnext=0,lw(t)},fw=(t,e)=>{let n;if(Ci(t))return dn;const r=t.state;return e<0?(n=0,e=-e):(n=(e>>4)+5,e<48&&(e&=15)),e&&(e<8||e>15)?dn:(r.window!==null&&r.wbits!==e&&(r.window=null),r.wrap=n,r.wbits=e,uw(t))},hw=(t,e)=>{if(!t)return dn;const n=new IR;t.state=n,n.strm=t,n.window=null,n.mode=Hl;const r=fw(t,e);return r!==Si&&(t.state=null),r},TR=t=>hw(t,CR);let dw=!0,vd,Ad;const DR=t=>{if(dw){vd=new Int32Array(512),Ad=new Int32Array(32);let e=0;for(;e<144;)t.lens[e++]=8;for(;e<256;)t.lens[e++]=9;for(;e<280;)t.lens[e++]=7;for(;e<288;)t.lens[e++]=8;for(Ca(F2,t.lens,0,288,vd,0,t.work,{bits:9}),e=0;e<32;)t.lens[e++]=5;Ca(M2,t.lens,0,32,Ad,0,t.work,{bits:5}),dw=!1}t.lencode=vd,t.lenbits=9,t.distcode=Ad,t.distbits=5},pw=(t,e,n,r)=>{let o;const i=t.state;return i.window===null&&(i.wsize=1<<i.wbits,i.wnext=0,i.whave=0,i.window=new Uint8Array(i.wsize)),r>=i.wsize?(i.window.set(e.subarray(n-i.wsize,n),0),i.wnext=0,i.whave=i.wsize):(o=i.wsize-i.wnext,o>r&&(o=r),i.window.set(e.subarray(n-r,n-r+o),i.wnext),r-=o,r?(i.window.set(e.subarray(n-r,n),0),i.wnext=r,i.whave=i.wsize):(i.wnext+=o,i.wnext===i.wsize&&(i.wnext=0),i.whave<i.wsize&&(i.whave+=o))),0},BR=(t,e)=>{let n,r,o,i,s,a,c,l,u,f,d,h,p,b,v=0,y,A,S,E,I,_,B,N;const F=new Uint8Array(4);let M,C;const Y=new Uint8Array([16,17,18,0,8,7,9,6,10,5,11,4,12,3,13,2,14,1,15]);if(Ci(t)||!t.output||!t.input&&t.avail_in!==0)return dn;n=t.state,n.mode===tr&&(n.mode=yd),s=t.next_out,o=t.output,c=t.avail_out,i=t.next_in,r=t.input,a=t.avail_in,l=n.hold,u=n.bits,f=a,d=c,N=Si;e:for(;;)switch(n.mode){case Hl:if(n.wrap===0){n.mode=yd;break}for(;u<16;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(n.wrap&2&&l===35615){n.wbits===0&&(n.wbits=15),n.check=0,F[0]=l&255,F[1]=l>>>8&255,n.check=Vn(n.check,F,2,0),l=0,u=0,n.mode=z2;break}if(n.head&&(n.head.done=!1),!(n.wrap&1)||(((l&255)<<8)+(l>>8))%31){t.msg="incorrect header check",n.mode=ct;break}if((l&15)!==N2){t.msg="unknown compression method",n.mode=ct;break}if(l>>>=4,u-=4,B=(l&15)+8,n.wbits===0&&(n.wbits=B),B>15||B>n.wbits){t.msg="invalid window size",n.mode=ct;break}n.dmax=1<<n.wbits,n.flags=0,t.adler=n.check=1,n.mode=l&512?Y2:tr,l=0,u=0;break;case z2:for(;u<16;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(n.flags=l,(n.flags&255)!==N2){t.msg="unknown compression method",n.mode=ct;break}if(n.flags&57344){t.msg="unknown header flags set",n.mode=ct;break}n.head&&(n.head.text=l>>8&1),n.flags&512&&n.wrap&4&&(F[0]=l&255,F[1]=l>>>8&255,n.check=Vn(n.check,F,2,0)),l=0,u=0,n.mode=U2;case U2:for(;u<32;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}n.head&&(n.head.time=l),n.flags&512&&n.wrap&4&&(F[0]=l&255,F[1]=l>>>8&255,F[2]=l>>>16&255,F[3]=l>>>24&255,n.check=Vn(n.check,F,4,0)),l=0,u=0,n.mode=G2;case G2:for(;u<16;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}n.head&&(n.head.xflags=l&255,n.head.os=l>>8),n.flags&512&&n.wrap&4&&(F[0]=l&255,F[1]=l>>>8&255,n.check=Vn(n.check,F,2,0)),l=0,u=0,n.mode=H2;case H2:if(n.flags&1024){for(;u<16;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}n.length=l,n.head&&(n.head.extra_len=l),n.flags&512&&n.wrap&4&&(F[0]=l&255,F[1]=l>>>8&255,n.check=Vn(n.check,F,2,0)),l=0,u=0}else n.head&&(n.head.extra=null);n.mode=V2;case V2:if(n.flags&1024&&(h=n.length,h>a&&(h=a),h&&(n.head&&(B=n.head.extra_len-n.length,n.head.extra||(n.head.extra=new Uint8Array(n.head.extra_len)),n.head.extra.set(r.subarray(i,i+h),B)),n.flags&512&&n.wrap&4&&(n.check=Vn(n.check,r,h,i)),a-=h,i+=h,n.length-=h),n.length))break e;n.length=0,n.mode=q2;case q2:if(n.flags&2048){if(a===0)break e;h=0;do B=r[i+h++],n.head&&B&&n.length<65536&&(n.head.name+=String.fromCharCode(B));while(B&&h<a);if(n.flags&512&&n.wrap&4&&(n.check=Vn(n.check,r,h,i)),a-=h,i+=h,B)break e}else n.head&&(n.head.name=null);n.length=0,n.mode=j2;case j2:if(n.flags&4096){if(a===0)break e;h=0;do B=r[i+h++],n.head&&B&&n.length<65536&&(n.head.comment+=String.fromCharCode(B));while(B&&h<a);if(n.flags&512&&n.wrap&4&&(n.check=Vn(n.check,r,h,i)),a-=h,i+=h,B)break e}else n.head&&(n.head.comment=null);n.mode=W2;case W2:if(n.flags&512){for(;u<16;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(n.wrap&4&&l!==(n.check&65535)){t.msg="header crc mismatch",n.mode=ct;break}l=0,u=0}n.head&&(n.head.hcrc=n.flags>>9&1,n.head.done=!0),t.adler=n.check=0,n.mode=tr;break;case Y2:for(;u<32;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}t.adler=n.check=cw(l),l=0,u=0,n.mode=Vl;case Vl:if(n.havedict===0)return t.next_out=s,t.avail_out=c,t.next_in=i,t.avail_in=a,n.hold=l,n.bits=u,vR;t.adler=n.check=1,n.mode=tr;case tr:if(e===wR||e===Gl)break e;case yd:if(n.last){l>>>=u&7,u-=u&7,n.mode=xd;break}for(;u<3;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}switch(n.last=l&1,l>>>=1,u-=1,l&3){case 0:n.mode=Q2;break;case 1:if(DR(n),n.mode=ql,e===Gl){l>>>=2,u-=2;break e}break;case 2:n.mode=X2;break;case 3:t.msg="invalid block type",n.mode=ct}l>>>=2,u-=2;break;case Q2:for(l>>>=u&7,u-=u&7;u<32;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if((l&65535)!==(l>>>16^65535)){t.msg="invalid stored block lengths",n.mode=ct;break}if(n.length=l&65535,l=0,u=0,n.mode=wd,e===Gl)break e;case wd:n.mode=Z2;case Z2:if(h=n.length,h){if(h>a&&(h=a),h>c&&(h=c),h===0)break e;o.set(r.subarray(i,i+h),s),a-=h,i+=h,c-=h,s+=h,n.length-=h;break}n.mode=tr;break;case X2:for(;u<14;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(n.nlen=(l&31)+257,l>>>=5,u-=5,n.ndist=(l&31)+1,l>>>=5,u-=5,n.ncode=(l&15)+4,l>>>=4,u-=4,n.nlen>286||n.ndist>30){t.msg="too many length or distance symbols",n.mode=ct;break}n.have=0,n.mode=K2;case K2:for(;n.have<n.ncode;){for(;u<3;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}n.lens[Y[n.have++]]=l&7,l>>>=3,u-=3}for(;n.have<19;)n.lens[Y[n.have++]]=0;if(n.lencode=n.lendyn,n.lenbits=7,M={bits:n.lenbits},N=Ca(yR,n.lens,0,19,n.lencode,0,n.work,M),n.lenbits=M.bits,N){t.msg="invalid code lengths set",n.mode=ct;break}n.have=0,n.mode=J2;case J2:for(;n.have<n.nlen+n.ndist;){for(;v=n.lencode[l&(1<<n.lenbits)-1],y=v>>>24,A=v>>>16&255,S=v&65535,!(y<=u);){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(S<16)l>>>=y,u-=y,n.lens[n.have++]=S;else{if(S===16){for(C=y+2;u<C;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(l>>>=y,u-=y,n.have===0){t.msg="invalid bit length repeat",n.mode=ct;break}B=n.lens[n.have-1],h=3+(l&3),l>>>=2,u-=2}else if(S===17){for(C=y+3;u<C;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}l>>>=y,u-=y,B=0,h=3+(l&7),l>>>=3,u-=3}else{for(C=y+7;u<C;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}l>>>=y,u-=y,B=0,h=11+(l&127),l>>>=7,u-=7}if(n.have+h>n.nlen+n.ndist){t.msg="invalid bit length repeat",n.mode=ct;break}for(;h--;)n.lens[n.have++]=B}}if(n.mode===ct)break;if(n.lens[256]===0){t.msg="invalid code -- missing end-of-block",n.mode=ct;break}if(n.lenbits=9,M={bits:n.lenbits},N=Ca(F2,n.lens,0,n.nlen,n.lencode,0,n.work,M),n.lenbits=M.bits,N){t.msg="invalid literal/lengths set",n.mode=ct;break}if(n.distbits=6,n.distcode=n.distdyn,M={bits:n.distbits},N=Ca(M2,n.lens,n.nlen,n.ndist,n.distcode,0,n.work,M),n.distbits=M.bits,N){t.msg="invalid distances set",n.mode=ct;break}if(n.mode=ql,e===Gl)break e;case ql:n.mode=jl;case jl:if(a>=6&&c>=258){t.next_out=s,t.avail_out=c,t.next_in=i,t.avail_in=a,n.hold=l,n.bits=u,dR(t,d),s=t.next_out,o=t.output,c=t.avail_out,i=t.next_in,r=t.input,a=t.avail_in,l=n.hold,u=n.bits,n.mode===tr&&(n.back=-1);break}for(n.back=0;v=n.lencode[l&(1<<n.lenbits)-1],y=v>>>24,A=v>>>16&255,S=v&65535,!(y<=u);){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(A&&!(A&240)){for(E=y,I=A,_=S;v=n.lencode[_+((l&(1<<E+I)-1)>>E)],y=v>>>24,A=v>>>16&255,S=v&65535,!(E+y<=u);){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}l>>>=E,u-=E,n.back+=E}if(l>>>=y,u-=y,n.back+=y,n.length=S,A===0){n.mode=rw;break}if(A&32){n.back=-1,n.mode=tr;break}if(A&64){t.msg="invalid literal/length code",n.mode=ct;break}n.extra=A&15,n.mode=$2;case $2:if(n.extra){for(C=n.extra;u<C;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}n.length+=l&(1<<n.extra)-1,l>>>=n.extra,u-=n.extra,n.back+=n.extra}n.was=n.length,n.mode=ew;case ew:for(;v=n.distcode[l&(1<<n.distbits)-1],y=v>>>24,A=v>>>16&255,S=v&65535,!(y<=u);){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(!(A&240)){for(E=y,I=A,_=S;v=n.distcode[_+((l&(1<<E+I)-1)>>E)],y=v>>>24,A=v>>>16&255,S=v&65535,!(E+y<=u);){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}l>>>=E,u-=E,n.back+=E}if(l>>>=y,u-=y,n.back+=y,A&64){t.msg="invalid distance code",n.mode=ct;break}n.offset=S,n.extra=A&15,n.mode=tw;case tw:if(n.extra){for(C=n.extra;u<C;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}n.offset+=l&(1<<n.extra)-1,l>>>=n.extra,u-=n.extra,n.back+=n.extra}if(n.offset>n.dmax){t.msg="invalid distance too far back",n.mode=ct;break}n.mode=nw;case nw:if(c===0)break e;if(h=d-c,n.offset>h){if(h=n.offset-h,h>n.whave&&n.sane){t.msg="invalid distance too far back",n.mode=ct;break}h>n.wnext?(h-=n.wnext,p=n.wsize-h):p=n.wnext-h,h>n.length&&(h=n.length),b=n.window}else b=o,p=s-n.offset,h=n.length;h>c&&(h=c),c-=h,n.length-=h;do o[s++]=b[p++];while(--h);n.length===0&&(n.mode=jl);break;case rw:if(c===0)break e;o[s++]=n.length,c--,n.mode=jl;break;case xd:if(n.wrap){for(;u<32;){if(a===0)break e;a--,l|=r[i++]<<u,u+=8}if(d-=c,t.total_out+=d,n.total+=d,n.wrap&4&&d&&(t.adler=n.check=n.flags?Vn(n.check,o,d,s-d):pd(n.check,o,d,s-d)),d=c,n.wrap&4&&(n.flags?l:cw(l))!==n.check){t.msg="incorrect data check",n.mode=ct;break}l=0,u=0}n.mode=iw;case iw:if(n.wrap&&n.flags){for(;u<32;){if(a===0)break e;a--,l+=r[i++]<<u,u+=8}if(n.wrap&4&&l!==(n.total&4294967295)){t.msg="incorrect length check",n.mode=ct;break}l=0,u=0}n.mode=ow;case ow:N=xR;break e;case ct:N=L2;break e;case sw:return O2;case aw:default:return dn}return t.next_out=s,t.avail_out=c,t.next_in=i,t.avail_in=a,n.hold=l,n.bits=u,(n.wsize||d!==t.avail_out&&n.mode<ct&&(n.mode<xd||e!==P2))&&pw(t,t.output,t.next_out,d-t.avail_out),f-=t.avail_in,d-=t.avail_out,t.total_in+=f,t.total_out+=d,n.total+=d,n.wrap&4&&d&&(t.adler=n.check=n.flags?Vn(n.check,o,d,t.next_out-d):pd(n.check,o,d,t.next_out-d)),t.data_type=n.bits+(n.last?64:0)+(n.mode===tr?128:0)+(n.mode===ql||n.mode===wd?256:0),(f===0&&d===0||e===P2)&&N===Si&&(N=AR),N},kR=t=>{if(Ci(t))return dn;let e=t.state;return e.window&&(e.window=null),t.state=null,Si},_R=(t,e)=>{if(Ci(t))return dn;const n=t.state;return n.wrap&2?(n.head=e,e.done=!1,Si):dn},RR=(t,e)=>{const n=e.length;let r,o,i;return Ci(t)||(r=t.state,r.wrap!==0&&r.mode!==Vl)?dn:r.mode===Vl&&(o=1,o=pd(o,e,n,0),o!==r.check)?L2:(i=pw(t,e,n,n),i?(r.mode=sw,O2):(r.havedict=1,Si))};var FR=uw,MR=fw,PR=lw,LR=TR,OR=hw,NR=BR,zR=kR,UR=_R,GR=RR,HR="pako inflate (from Nodeca project)",nr={inflateReset:FR,inflateReset2:MR,inflateResetKeep:PR,inflateInit:LR,inflateInit2:OR,inflate:NR,inflateEnd:zR,inflateGetHeader:UR,inflateSetDictionary:GR,inflateInfo:HR};function VR(){this.text=0,this.time=0,this.xflags=0,this.os=0,this.extra=null,this.extra_len=0,this.name="",this.comment="",this.hcrc=0,this.done=!1}var qR=VR;const gw=Object.prototype.toString,{Z_NO_FLUSH:jR,Z_FINISH:WR,Z_OK:Ia,Z_STREAM_END:Ed,Z_NEED_DICT:Sd,Z_STREAM_ERROR:YR,Z_DATA_ERROR:mw,Z_MEM_ERROR:QR}=I2;function Wl(t){this.options=T2.assign({chunkSize:1024*64,windowBits:15,to:""},t||{});const 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Uint8Array(t):n.input=t,n.next_in=0,n.avail_in=n.input.length;;){for(n.avail_out===0&&(n.output=new Uint8Array(r),n.next_out=0,n.avail_out=r),i=nr.inflate(n,s),i===Sd&&o&&(i=nr.inflateSetDictionary(n,o),i===Ia?i=nr.inflate(n,s):i===mw&&(i=Sd));n.avail_in>0&&i===Ed&&n.state.wrap>0&&t[n.next_in]!==0;)nr.inflateReset(n),i=nr.inflate(n,s);switch(i){case YR:case mw:case Sd:case QR:return this.onEnd(i),this.ended=!0,!1}if(a=n.avail_out,n.next_out&&(n.avail_out===0||i===Ed))if(this.options.to==="string"){let c=md.utf8border(n.output,n.next_out),l=n.next_out-c,u=md.buf2string(n.output,c);n.next_out=l,n.avail_out=r-l,l&&n.output.set(n.output.subarray(c,c+l),0),this.onData(u)}else this.onData(n.output.length===n.next_out?n.output:n.output.subarray(0,n.next_out));if(!(i===Ia&&a===0)){if(i===Ed)return i=nr.inflateEnd(this.strm),this.onEnd(i),this.ended=!0,!0;if(n.avail_in===0)break}}return!0},Wl.prototype.onData=function(t){this.chunks.push(t)},Wl.prototype.onEnd=function(t){t===Ia&&(this.options.to==="string"?this.result=this.chunks.join(""):this.result=T2.flattenChunks(this.chunks)),this.chunks=[],this.err=t,this.msg=this.strm.msg};function ZR(t,e){const n=new Wl(e);if(n.push(t),n.err)throw n.msg||gd[n.err];return n.result}function XR(t,e){return e=e||{},e.raw=!0,ZR(t,e)}var KR=XR,JR={inflateRaw:KR};const{inflateRaw:$R}=JR;var eF=$R;function tF(t){return eF(t.subarray(2))}let nF=class extends Error{constructor(e){super(e),this.code="ERR_ABORTED"}};function rF(t){t.sort((o,i)=>o.offset-i.offset);const e=[];let n,r;for(const o of t)n&&r&&o.offset-r<=2e3?(n.length=n.length+o.length-r+o.offset,n.blocks.push(o)):e.push(n={blocks:[o],length:o.length,offset:o.offset}),r=n.offset+n.length;return e}function Yl(t){if(t&&t.aborted)if(typeof DOMException>"u"){const e=new nF("aborted");throw 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Y=M.getUint8(C);C+=2;const Q=M.getUint16(C,v);if(C+=2,Y===1){const se=[];for(let oe=0;oe<Q;oe++){const ae=M.getUint32(C,v);C+=4;const ce=M.getUint32(C,v);C+=4;const ye=M.getUint32(C,v);C+=4;const he=M.getUint32(C,v);C+=4;const De=Number(M.getBigUint64(C,v));C+=8;const we=Number(M.getBigUint64(C,v));C+=8,se.push({startChrom:ae,startBase:ce,endBase:he,endChrom:ye,blockOffset:De,blockSize:we,offset:C})}p=p.concat(se.filter(oe=>A(oe)).map(oe=>({offset:oe.blockOffset,length:oe.blockSize})))}else if(Y===0){const se=[];for(let ae=0;ae<Q;ae++){const ce=M.getUint32(C,v);C+=4;const ye=M.getUint32(C,v);C+=4;const he=M.getUint32(C,v);C+=4;const De=M.getUint32(C,v);C+=4;const we=Number(M.getBigUint64(C,v));C+=8,se.push({startChrom:ce,startBase:ye,endChrom:he,endBase:De,blockOffset:we,offset:C})}const oe=se.filter(ae=>A(ae)).map(ae=>ae.blockOffset);oe.length>0&&E(oe,B+1)}}catch(N){o.error(N)}},A=I=>{const{startChrom:_,startBase:B,endChrom:N,endBase:F}=I;return(_<u||_===u&&B<=r)&&(N>u||N===u&&F>=n)},S=async(I,_,B)=>{try{const N=_.max-_.min,F=_.min,M=await this.featureCache.get(`${N}_${F}`,{length:N,offset:F},i==null?void 0:i.signal);for(const C of I)_.contains(C)&&(y(M,C-F,B),b-=1,b===0&&this.readFeatures(o,p,{...i,request:f}).catch(Y=>{o.error(Y)}))}catch(N){o.error(N)}},E=(I,_)=>{try{b+=I.length;const B=4+h*32;let N=new wo([{min:I[0],max:I[0]+B}]);for(let F=1;F<I.length;F+=1){const M=new wo([{min:I[F],max:I[F]+B}]);N=N.union(M)}N.getRanges().map(F=>S(I,F,_))}catch(B){o.error(B)}};E([Number(c)+48],1);return}catch(s){o.error(s)}}parseSummaryBlock(e,n,r){const o=[];let i=n;const s=new DataView(e.buffer,e.byteOffset,e.length);for(;i<e.byteLength;){const a=s.getUint32(i,!0);i+=4;const c=s.getUint32(i,!0);i+=4;const l=s.getUint32(i,!0);i+=4;const u=s.getUint32(i,!0);i+=4;const f=s.getFloat32(i,!0);i+=4;const d=s.getFloat32(i,!0);i+=4;const h=s.getFloat32(i,!0);i+=4,i+=4,(!r||a===r.chrId&&Id(c,l,r.start,r.end))&&o.push({start:c,end:l,maxScore:d,minScore:f,summary:!0,score:h/(u||1)})}return o}parseBigBedBlock(e,n,r,o){var i;const s=[];let a=n;const c=!0,l=e,u=new DataView(l.buffer,l.byteOffset,l.length);for(;a<e.byteLength;){const f=a,d=u.getUint32(a,c);a+=4;const h=u.getInt32(a,c);a+=4;const p=u.getInt32(a,c);a+=4;let b=a;for(;b<e.length&&e[b]!==0;b++);const v=e.subarray(a,b),y=(i=Cd==null?void 0:Cd.decode(v))!==null&&i!==void 0?i:v.toString();a=b+1,s.push({chromId:d,start:h,end:p,rest:y,uniqueId:`bb-${r+f}`})}return o?s.filter(f=>Id(f.start,f.end,o.start,o.end)):s}parseBigWigBlock(e,n,r){const o=e.subarray(n),i=new DataView(o.buffer,o.byteOffset,o.length);let s=0;s+=4;const a=i.getInt32(s,!0);s+=8;const c=i.getUint32(s,!0);s+=4;const l=i.getUint32(s,!0);s+=4;const u=i.getUint8(s);s+=2;const f=i.getUint16(s,!0);s+=2;const d=new Array(f);switch(u){case 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this.bbi.read(Ke.Buffer.alloc(64),0,64,Number(n)),i=!r,s=o,a=new DataView(s.buffer,s.byteOffset,s.length);let c=0;c+=2;const l=a.getUint16(c,i);c+=2;const u=Number(a.getBigUint64(c,i));if(c+=8,l===0)return[];const f=20,d=f*l,{buffer:h}=await this.bbi.read(Ke.Buffer.alloc(d),0,d,Number(u)),p=[];for(let b=0;b<l;b+=1){const v=h.subarray(b*f),y=new DataView(v.buffer,v.byteOffset,v.length);let A=0;const S=y.getInt16(A,i);A+=2;const E=y.getInt16(A,i);A+=2;const I=Number(y.getBigUint64(A,i));A+=12;const _=y.getInt16(A,i);p.push({type:S,fieldcount:E,offset:Number(I),field:_})}return p}async searchExtraIndexBlocks(e,n={}){const{isBigEndian:r}=await this.getHeader(n),o=await this.readIndices(n);if(o.length===0)return[];const i=o.map(async s=>{const{offset:a,field:c}=s,{buffer:l}=await this.bbi.read(Ke.Buffer.alloc(32),0,32,a,n),u=!r,f=l,d=new DataView(f.buffer,f.byteOffset,f.length);let h=0;h+=4;const p=d.getInt32(h,u);h+=4;const b=d.getInt32(h,u);h+=4;const v=d.getInt32(h,u);h+=4,h+=8;const y=async S=>{const E=Number(S),I=4+p*(b+v),{buffer:_}=await this.bbi.read(Ke.Buffer.alloc(I),0,I,E,n),B=_,N=new DataView(B.buffer,B.byteOffset,B.length);let F=0;const M=N.getInt8(F);F+=2;const C=N.getInt16(F,u);F+=2;const Y=[];if(M===0){const Q=[];for(let oe=0;oe<C;oe++){const ae=B.subarray(F,F+b).toString().replaceAll("\0","");F+=b;const ce=Number(N.getBigUint64(F,u));F+=8,Q.push({key:ae,offset:ce})}let se=0;for(const{key:oe,offset:ae}of Q){if(e.localeCompare(oe)<0&&se)return y(se);se=ae}return y(se)}else if(M===1){for(let Q=0;Q<C;Q++){const se=B.subarray(F,F+b).toString().replaceAll("\0","");F+=b;const oe=Number(N.getBigUint64(F,u));F+=8;const ae=N.getUint32(F,u);F+=4;const ce=N.getUint32(F,u);F+=4,Y.push({key:se,offset:oe,length:ae,reserved:ce})}for(const Q of Y)if(Q.key===e)return{...Q,field:c};return}};return y(a+32)});return qF(await Promise.all(i))}async searchExtraIndex(e,n={}){const r=await this.searchExtraIndexBlocks(e,n);if(r.length===0)return[];const o=await 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654
654
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`,"\r"],!0,!1),R=function(P){return P.join("").replace(/^"/,"").replace(/"$/,"")},H=on("integer"),Z=/^[0-9]/,Ce=ht([["0","9"]],!1,!1),me=function(){return parseInt(ft(),10)},xe=on("whitespace"),Ue=/^[ \t\n\r]/,bn=ht([" "," ",`
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655
|
-
`,"\r"],!1,!1),U=0,Me=0,lt=[{line:1,column:1}],tt=0,Tt=[],ke=0,ar;if("startRule"in o){if(!(o.startRule in s))throw new Error(`Can't start parsing from rule "`+o.startRule+'".');a=s[o.startRule]}function ft(){return r.substring(Me,U)}function Ne(P,ne){return{type:"literal",text:P,ignoreCase:ne}}function ht(P,ne,pe){return{type:"class",parts:P,inverted:ne,ignoreCase:pe}}function Bn(){return{type:"end"}}function on(P){return{type:"other",description:P}}function $a(P){var ne=lt[P],pe;if(ne)return ne;for(pe=P-1;!lt[pe];)pe--;for(ne=lt[pe],ne={line:ne.line,column:ne.column};pe<P;)r.charCodeAt(pe)===10?(ne.line++,ne.column=1):ne.column++,pe++;return lt[P]=ne,ne}function tv(P,ne){var pe=$a(P),be=$a(ne);return{start:{offset:P,line:pe.line,column:pe.column},end:{offset:ne,line:be.line,column:be.column}}}function Le(P){U<tt||(U>tt&&(tt=U,Tt=[]),Tt.push(P))}function Z9(P,ne,pe){return new e(e.buildMessage(P,ne),P,ne,pe)}function nv(){var P,ne,pe,be,Fe,rt,ut,yn,jr,cr,Wr,lr,Yr,ur;return P=U,ne=qe(),ne!==i?(pe=rv(),pe!==i?(be=qe(),be!==i?(Fe=iv(),Fe!==i?(rt=qe(),rt!==i?(ut=fu(),ut!==i?(yn=qe(),yn!==i?(r.charCodeAt(U)===40?(jr=c,U++):(jr=i,ke===0&&Le(l)),jr!==i?(cr=qe(),cr!==i?(Wr=X9(),Wr!==i?(lr=qe(),lr!==i?(r.charCodeAt(U)===41?(Yr=u,U++):(Yr=i,ke===0&&Le(f)),Yr!==i?(ur=qe(),ur!==i?(Me=P,ne=d(pe,Fe,ut,Wr),P=ne):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)):(U=P,P=i),P}function rv(){var P;return r.substr(U,6)===h?(P=h,U+=6):(P=i,ke===0&&Le(p)),P===i&&(r.substr(U,6)===b?(P=b,U+=6):(P=i,ke===0&&Le(v)),P===i&&(r.substr(U,5)===y?(P=y,U+=5):(P=i,ke===0&&Le(A)))),P}function iv(){var P,ne,pe,be;return P=kn(),P===i&&(P=U,ne=kn(),ne!==i?(pe=ov(),pe!==i?(ne=[ne,pe],P=ne):(U=P,P=i)):(U=P,P=i),P===i&&(P=U,ne=kn(),ne!==i?(r.substr(U,4)===S?(pe=S,U+=4):(pe=i,ke===0&&Le(E)),pe!==i?(ne=[ne,pe],P=ne):(U=P,P=i)):(U=P,P=i),P===i&&(P=U,ne=kn(),ne!==i?(pe=ov(),pe!==i?(r.substr(U,4)===S?(be=S,U+=4):(be=i,ke===0&&Le(E)),be!==i?(ne=[ne,pe,be],P=ne):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)))),P}function ov(){var P;return r.substr(U,7)===I?(P=I,U+=7):(P=i,ke===0&&Le(_)),P===i&&(r.substr(U,5)===B?(P=B,U+=5):(P=i,ke===0&&Le(N)),P===i&&(r.substr(U,6)===
|
|
655
|
+
`,"\r"],!1,!1),U=0,Me=0,lt=[{line:1,column:1}],tt=0,Tt=[],ke=0,ar;if("startRule"in o){if(!(o.startRule in s))throw new Error(`Can't start parsing from rule "`+o.startRule+'".');a=s[o.startRule]}function ft(){return r.substring(Me,U)}function Ne(P,ne){return{type:"literal",text:P,ignoreCase:ne}}function ht(P,ne,pe){return{type:"class",parts:P,inverted:ne,ignoreCase:pe}}function Bn(){return{type:"end"}}function on(P){return{type:"other",description:P}}function $a(P){var ne=lt[P],pe;if(ne)return ne;for(pe=P-1;!lt[pe];)pe--;for(ne=lt[pe],ne={line:ne.line,column:ne.column};pe<P;)r.charCodeAt(pe)===10?(ne.line++,ne.column=1):ne.column++,pe++;return lt[P]=ne,ne}function tv(P,ne){var pe=$a(P),be=$a(ne);return{start:{offset:P,line:pe.line,column:pe.column},end:{offset:ne,line:be.line,column:be.column}}}function Le(P){U<tt||(U>tt&&(tt=U,Tt=[]),Tt.push(P))}function Z9(P,ne,pe){return new e(e.buildMessage(P,ne),P,ne,pe)}function nv(){var P,ne,pe,be,Fe,rt,ut,yn,jr,cr,Wr,lr,Yr,ur;return 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P=kn(),P===i&&(P=U,ne=kn(),ne!==i?(pe=ov(),pe!==i?(ne=[ne,pe],P=ne):(U=P,P=i)):(U=P,P=i),P===i&&(P=U,ne=kn(),ne!==i?(r.substr(U,4)===S?(pe=S,U+=4):(pe=i,ke===0&&Le(E)),pe!==i?(ne=[ne,pe],P=ne):(U=P,P=i)):(U=P,P=i),P===i&&(P=U,ne=kn(),ne!==i?(pe=ov(),pe!==i?(r.substr(U,4)===S?(be=S,U+=4):(be=i,ke===0&&Le(E)),be!==i?(ne=[ne,pe,be],P=ne):(U=P,P=i)):(U=P,P=i)):(U=P,P=i)))),P}function ov(){var P;return r.substr(U,7)===I?(P=I,U+=7):(P=i,ke===0&&Le(_)),P===i&&(r.substr(U,5)===B?(P=B,U+=5):(P=i,ke===0&&Le(N)),P===i&&(r.substr(U,6)===F?(P=F,U+=6):(P=i,ke===0&&Le(M)))),P}function fu(){var P;return P=sv(),P===i&&(P=qe()),P}function X9(){var P,ne,pe,be,Fe,rt,ut;if(P=U,ne=f0(),ne!==i)if(pe=qe(),pe!==i){for(be=[],Fe=U,rt=qe(),rt!==i?(ut=f0(),ut!==i?(Me=Fe,rt=C(ne,ut),Fe=rt):(U=Fe,Fe=i)):(U=Fe,Fe=i);Fe!==i;)be.push(Fe),Fe=U,rt=qe(),rt!==i?(ut=f0(),ut!==i?(Me=Fe,rt=C(ne,ut),Fe=rt):(U=Fe,Fe=i)):(U=Fe,Fe=i);be!==i?(Fe=qe(),Fe!==i?(Me=P,ne=Y(ne,be),P=ne):(U=P,P=i)):(U=P,P=i)}else U=P,P=i;else 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$9(){var P,ne,pe,be,Fe,rt,ut;if(P=U,ne=kn(),ne!==i){for(pe=[],be=U,r.charCodeAt(U)===44?(Fe=Ge,U++):(Fe=i,ke===0&&Le(Ve)),Fe!==i?(rt=qe(),rt!==i?(ut=kn(),ut!==i?(Me=be,Fe=C(ne,ut),be=Fe):(U=be,be=i)):(U=be,be=i)):(U=be,be=i);be!==i;)pe.push(be),be=U,r.charCodeAt(U)===44?(Fe=Ge,U++):(Fe=i,ke===0&&Le(Ve)),Fe!==i?(rt=qe(),rt!==i?(ut=kn(),ut!==i?(Me=be,Fe=C(ne,ut),be=Fe):(U=be,be=i)):(U=be,be=i)):(U=be,be=i);pe!==i?(Me=P,ne=q(ne,pe),P=ne):(U=P,P=i)}else U=P,P=i;return P}function h0(){var P,ne,pe,be;return r.substr(U,3)===j?(P=j,U+=3):(P=i,ke===0&&Le(ee)),P===i&&(r.substr(U,4)===J?(P=J,U+=4):(P=i,ke===0&&Le(fe)),P===i&&(r.substr(U,5)===L?(P=L,U+=5):(P=i,ke===0&&Le(D)),P===i&&(r.substr(U,6)===te?(P=te,U+=6):(P=i,ke===0&&Le(le)),P===i&&(r.substr(U,4)===Be?(P=Be,U+=4):(P=i,ke===0&&Le(ve)),P===i&&(r.substr(U,5)===Ae?(P=Ae,U+=5):(P=i,ke===0&&Le(Re)),P===i&&(r.substr(U,5)===dt?(P=dt,U+=5):(P=i,ke===0&&Le($t)),P===i&&(r.substr(U,4)===It?(P=It,U+=4):(P=i,ke===0&&Le($e)),P===i&&(r.substr(U,6)===Rt?(P=Rt,U+=6):(P=i,ke===0&&Le(Nt)),P===i&&(r.substr(U,7)===et?(P=et,U+=7):(P=i,ke===0&&Le(zt)),P===i&&(r.substr(U,4)===k?(P=k,U+=4):(P=i,ke===0&&Le(m)),P===i&&(r.substr(U,6)===w?(P=w,U+=6):(P=i,ke===0&&Le(O)),P===i&&(r.substr(U,6)===x?(P=x,U+=6):(P=i,ke===0&&Le(z)),P===i&&(r.substr(U,3)===V?(P=V,U+=3):(P=i,ke===0&&Le(ue)),P===i&&(P=U,ne=rv(),ne!==i?(pe=qe(),pe!==i?(be=iv(),be!==i?(Me=P,ne=G(ne,be),P=ne):(U=P,P=i)):(U=P,P=i)):(U=P,P=i))))))))))))))),P}function eM(){var P;return P=tM(),P===i&&(P=kn()),P}function kn(){var P,ne,pe,be,Fe;if(P=U,ne=U,X.test(r.charAt(U))?(pe=r.charAt(U),U++):(pe=i,ke===0&&Le(T)),pe!==i){for(be=[],re.test(r.charAt(U))?(Fe=r.charAt(U),U++):(Fe=i,ke===0&&Le(_e));Fe!==i;)be.push(Fe),re.test(r.charAt(U))?(Fe=r.charAt(U),U++):(Fe=i,ke===0&&Le(_e));be!==i?(pe=[pe,be],ne=pe):(U=ne,ne=i)}else U=ne,ne=i;return ne!==i&&(Me=P,ne=g()),P=ne,P}function sv(){var P,ne,pe;for(P=U,ne=[],K.test(r.charAt(U))?(pe=r.charAt(U),U++):(pe=i,ke===0&&Le($));pe!==i;)ne.push(pe),K.test(r.charAt(U))?(pe=r.charAt(U),U++):(pe=i,ke===0&&Le($));return ne!==i&&(Me=P,ne=R(ne)),P=ne,P}function tM(){var P,ne,pe,be;if(ke++,P=U,ne=qe(),ne!==i){if(pe=[],Z.test(r.charAt(U))?(be=r.charAt(U),U++):(be=i,ke===0&&Le(Ce)),be!==i)for(;be!==i;)pe.push(be),Z.test(r.charAt(U))?(be=r.charAt(U),U++):(be=i,ke===0&&Le(Ce));else pe=i;pe!==i?(Me=P,ne=me(),P=ne):(U=P,P=i)}else U=P,P=i;return ke--,P===i&&(ne=i,ke===0&&Le(H)),P}function qe(){var P,ne;for(ke++,P=[],Ue.test(r.charAt(U))?(ne=r.charAt(U),U++):(ne=i,ke===0&&Le(bn));ne!==i;)P.push(ne),Ue.test(r.charAt(U))?(ne=r.charAt(U),U++):(ne=i,ke===0&&Le(bn));return ke--,P===i&&(ne=i,ke===0&&Le(xe)),P}if(ar=a(),ar!==i&&U===r.length)return ar;throw ar!==i&&U<r.length&&Le(Bn()),Z9(Tt,tt<r.length?r.charAt(tt):null,tt<r.length?tv(tt,tt+1):tv(tt,tt))}return Ld={SyntaxError:e,parse:n},Ld}var Zw=WF();const YF=Ml(Zw),Od=Object.fromEntries(Object.entries(Object.freeze(Object.defineProperty({__proto__:null,bigChain:`table bigChain
|
|
656
656
|
"bigChain pairwise alignment"
|
|
657
657
|
(
|
|
658
658
|
string chrom; "Reference sequence chromosome or scaffold"
|
|
@@ -811,9 +811,9 @@ chrM 16299`};function SD(t){if(!(t in Gb))throw new Error(`Unknown assembly: ${t
|
|
|
811
811
|
float score; "Floating point score."
|
|
812
812
|
char[1] leftStatus; "Gap/break annotation for preceding block"
|
|
813
813
|
char[1] rightStatus; "Gap/break annotation for following block"
|
|
814
|
-
)`},Symbol.toStringTag,{value:"Module"}))).map(([t,e])=>[t,Zw.parse(e.trim())]));function Nd(t){const e=new Set(["uint","int","float","long"]);return{...t,fields:t.fields.map(n=>({...n,isArray:n.size&&n.type!=="char",arrayIsNumeric:n.size&&e.has(n.type),isNumeric:!n.size&&e.has(n.type)})).filter(n=>!!n.name)}}const QF={".":0,"-":-1,"+":1};function ZF(t){var e;return t.length>=12&&!Number.isNaN(parseInt(t[9],10))&&((e=t[10])===null||e===void 0?void 0:e.split(",").filter(n=>!!n).length)===parseInt(t[9],10)}class XF{constructor(e={}){if(e.autoSql)this.autoSql=Nd(YF.parse(e.autoSql));else if(e.type){if(!Od[e.type])throw new Error("Type not found");this.autoSql=Nd(Od[e.type])}else this.autoSql=Nd(Od.defaultBedSchema),this.attemptDefaultBed=!0}parseLine(e,n={}){const{autoSql:r}=this,{uniqueId:o}=n,i=Array.isArray(e)?e:e.split(" ");let s={};if(!this.attemptDefaultBed||this.attemptDefaultBed&&ZF(i))for(let a=0;a<r.fields.length;a++){const c=r.fields[a];let l=i[a];const{isNumeric:u,isArray:f,arrayIsNumeric:d,name:h}=c;if(l==null)break;if(l!=="."){if(u){const p=Number(l);l=Number.isNaN(p)?l:p}else f&&(l=l.split(","),l[l.length-1]===""&&l.pop(),d&&(l=l.map(Number)));s[h]=l}}else{const a=["chrom","chromStart","chromEnd","name"];s=Object.fromEntries(i.map((c,l)=>[a[l]||"field"+l,c])),s.chromStart=+s.chromStart,s.chromEnd=+s.chromEnd,Number.isNaN(Number.parseFloat(s.field4))||(s.score=+s.field4,delete s.field4),(s.field5==="+"||s.field5==="-")&&(s.strand=s.field5,delete s.field5)}return o&&(s.uniqueId=o),s.strand=QF[s.strand]||0,s.chrom=decodeURIComponent(s.chrom),s}}const KF=Object.freeze(Object.defineProperty({__proto__:null,default:XF},Symbol.toStringTag,{value:"Module"}));let Xw=class{constructor(e,n){this.blockPosition=e,this.dataPosition=n}toString(){return`${this.blockPosition}:${this.dataPosition}`}compareTo(e){return this.blockPosition-e.blockPosition||this.dataPosition-e.dataPosition}static min(...e){let n,r=0;for(;!n;r+=1)n=e[r];for(;r<e.length;r+=1)n.compareTo(e[r])>0&&(n=e[r]);return n}};function Co(t,e=0,n=!1){if(n)throw new Error("big-endian virtual file offsets not implemented");return new Xw(t[e+7]*1099511627776+t[e+6]*4294967296+t[e+5]*16777216+t[e+4]*65536+t[e+3]*256+t[e+2],t[e+1]<<8|t[e])}let zd=class{constructor(e,n,r,o){this.minv=e,this.maxv=n,this.bin=r,this._fetchedSize=o}toUniqueString(){return`${this.minv.toString()}..${this.maxv.toString()} (bin ${this.bin}, fetchedSize ${this.fetchedSize()})`}toString(){return this.toUniqueString()}compareTo(e){return this.minv.compareTo(e.minv)||this.maxv.compareTo(e.maxv)||this.bin-e.bin}fetchedSize(){return this._fetchedSize!==void 0?this._fetchedSize:this.maxv.blockPosition+65536-this.minv.blockPosition}};function JF(t){return new Promise(e=>setTimeout(e,t))}function $F(t){if(t&&t.aborted)if(typeof DOMException>"u"){const e=new Error("aborted");throw e.code="ERR_ABORTED",e}else throw new DOMException("aborted","AbortError")}function e9(t,e){return e.minv.blockPosition-t.maxv.blockPosition<65e3&&e.maxv.blockPosition-t.minv.blockPosition<5e6}function t9(t={}){return"aborted"in t?{signal:t}:t}function Kw(t,e){const n=[];let r;if(t.length===0)return t;t.sort((o,i)=>{const s=o.minv.blockPosition-i.minv.blockPosition;return s===0?o.minv.dataPosition-i.minv.dataPosition:s});for(const o of t)(!e||o.maxv.compareTo(e)>0)&&(r===void 0?(n.push(o),r=o):e9(r,o)?o.maxv.compareTo(r.maxv)>0&&(r.maxv=o.maxv):(n.push(o),r=o));return n}function Jw(t,e){return{lineCount:Ol.fromBytesLE(Array.prototype.slice.call(t,e,e+8),!0).toNumber()}}function Xl(t,e){return t?t.compareTo(e)>0?e:t:e}function n9(t,e=n=>n){let n=0,r=0;const o=[],i={};for(let s=0;s<t.length;s+=1)if(!t[s]){if(r<s){let a=t.toString("utf8",r,s);a=e(a),o[n]=a,i[a]=n}r=s+1,n+=1}return{refNameToId:i,refIdToName:o}}let $w=class{constructor({filehandle:e,renameRefSeq:n=r=>r}){this.filehandle=e,this.renameRefSeq=n}};const r9=21578050;function i9(t,e){return t-t%e}function o9(t,e){return t-t%e+e}function s9(t,e){return e-=1,[[0,0],[1+(t>>26),1+(e>>26)],[9+(t>>23),9+(e>>23)],[73+(t>>20),73+(e>>20)],[585+(t>>17),585+(e>>17)],[4681+(t>>14),4681+(e>>14)]]}class Io extends $w{async lineCount(e,n){var r,o;return((o=(r=(await this.parse(n)).indices[e])===null||r===void 0?void 0:r.stats)===null||o===void 0?void 0:o.lineCount)||0}async _parse(e){const n=await this.filehandle.readFile(e);if(n.readUInt32LE(0)!==r9)throw new Error("Not a BAI file");const r=n.readInt32LE(4),i=((1<<(5+1)*3)-1)/7;let s=8,a;const c=new Array(r);for(let l=0;l<r;l++){const u=n.readInt32LE(s);let f;s+=4;const d={};for(let b=0;b<u;b+=1){const v=n.readUInt32LE(s);if(s+=4,v===i+1)s+=4,f=Jw(n,s+16),s+=32;else{if(v>i+1)throw new Error("bai index contains too many bins, please use CSI");{const y=n.readInt32LE(s);s+=4;const A=new Array(y);for(let S=0;S<y;S++){const E=Co(n,s);s+=8;const I=Co(n,s);s+=8,a=Xl(a,E),A[S]=new zd(E,I,v)}d[v]=A}}}const h=n.readInt32LE(s);s+=4;const p=new Array(h);for(let b=0;b<h;b++){const v=Co(n,s);s+=8,a=Xl(a,v),p[b]=v}c[l]={binIndex:d,linearIndex:p,stats:f}}return{bai:!0,firstDataLine:a,maxBlockSize:65536,indices:c,refCount:r}}async indexCov(e,n,r,o={}){const s=n!==void 0,c=(await this.parse(o)).indices[e];if(!c)return[];const{linearIndex:l=[],stats:u}=c;if(l.length===0)return[];const f=r===void 0?(l.length-1)*16384:o9(r,16384),d=n===void 0?0:i9(n,16384),h=s?new Array((f-d)/16384):new Array(l.length-1),p=l[l.length-1].blockPosition;if(f>(l.length-1)*16384)throw new Error("query outside of range of linear index");let b=l[d/16384].blockPosition;for(let v=d/16384,y=0;v<f/16384;v++,y++)h[y]={score:l[v+1].blockPosition-b,start:v*16384,end:v*16384+16384},b=l[v+1].blockPosition;return h.map(v=>({...v,score:v.score*((u==null?void 0:u.lineCount)||0)/p}))}async blocksForRange(e,n,r,o={}){n<0&&(n=0);const i=await this.parse(o);if(!i)return[];const s=i.indices[e];if(!s)return[];const a=s9(n,r),c=[];for(const[h,p]of a)for(let b=h;b<=p;b++)if(s.binIndex[b]){const v=s.binIndex[b];for(const y of v)c.push(new zd(y.minv,y.maxv,b))}const l=s.linearIndex.length;let u;const f=Math.min(n>>14,l-1),d=Math.min(r>>14,l-1);for(let h=f;h<=d;++h){const p=s.linearIndex[h];p&&(!u||p.compareTo(u)<0)&&(u=p)}return Kw(c,u)}async parse(e={}){return this.setupP||(this.setupP=this._parse(e).catch(n=>{throw this.setupP=void 0,n})),this.setupP}async hasRefSeq(e,n={}){var r;return!!(!((r=(await this.parse(n)).indices[e])===null||r===void 0)&&r.binIndex)}}let Ud=[0,1996959894,3993919788,2567524794,124634137,1886057615,3915621685,2657392035,249268274,2044508324,3772115230,2547177864,162941995,2125561021,3887607047,2428444049,498536548,1789927666,4089016648,2227061214,450548861,1843258603,4107580753,2211677639,325883990,1684777152,4251122042,2321926636,335633487,1661365465,4195302755,2366115317,997073096,1281953886,3579855332,2724688242,1006888145,1258607687,3524101629,2768942443,901097722,1119000684,3686517206,2898065728,853044451,1172266101,3705015759,2882616665,651767980,1373503546,3369554304,3218104598,565507253,1454621731,3485111705,3099436303,671266974,1594198024,3322730930,2970347812,795835527,1483230225,3244367275,3060149565,1994146192,31158534,2563907772,4023717930,1907459465,112637215,2680153253,3904427059,2013776290,251722036,2517215374,3775830040,2137656763,141376813,2439277719,3865271297,1802195444,476864866,2238001368,4066508878,1812370925,453092731,2181625025,4111451223,1706088902,314042704,2344532202,4240017532,1658658271,366619977,2362670323,4224994405,1303535960,984961486,2747007092,3569037538,1256170817,1037604311,2765210733,3554079995,1131014506,879679996,2909243462,3663771856,1141124467,855842277,2852801631,3708648649,1342533948,654459306,3188396048,3373015174,1466479909,544179635,3110523913,3462522015,1591671054,702138776,2966460450,3352799412,1504918807,783551873,3082640443,3233442989,3988292384,2596254646,62317068,1957810842,3939845945,2647816111,81470997,1943803523,3814918930,2489596804,225274430,2053790376,3826175755,2466906013,167816743,2097651377,4027552580,2265490386,503444072,1762050814,4150417245,2154129355,426522225,1852507879,4275313526,2312317920,282753626,1742555852,4189708143,2394877945,397917763,1622183637,3604390888,2714866558,953729732,1340076626,3518719985,2797360999,1068828381,1219638859,3624741850,2936675148,906185462,1090812512,3747672003,2825379669,829329135,1181335161,3412177804,3160834842,628085408,1382605366,3423369109,3138078467,570562233,1426400815,3317316542,2998733608,733239954,1555261956,3268935591,3050360625,752459403,1541320221,2607071920,3965973030,1969922972,40735498,2617837225,3943577151,1913087877,83908371,2512341634,3803740692,2075208622,213261112,2463272603,3855990285,2094854071,198958881,2262029012,4057260610,1759359992,534414190,2176718541,4139329115,1873836001,414664567,2282248934,4279200368,1711684554,285281116,2405801727,4167216745,1634467795,376229701,2685067896,3608007406,1308918612,956543938,2808555105,3495958263,1231636301,1047427035,2932959818,3654703836,1088359270,936918e3,2847714899,3736837829,1202900863,817233897,3183342108,3401237130,1404277552,615818150,3134207493,3453421203,1423857449,601450431,3009837614,3294710456,1567103746,711928724,3020668471,3272380065,1510334235,755167117];typeof Int32Array<"u"&&(Ud=new Int32Array(Ud));const a9=(t,e)=>{let n=e===0?0:~~e^-1;for(let r=0;r<t.length;r++)n=Ud[(n^t[r])&255]^n>>>8;return n^-1},ex=(t,e)=>Ke.Buffer.from(t,e);function c9(t,e){const n=(r,o)=>e(ex(r),o)>>>0;return n.signed=(r,o)=>e(ex(r),o),n.unsigned=n,n.model=t,n}const l9=c9("crc-32",a9),u9=21582659,f9=38359875;function h9(t,e){return t*2**e}function tx(t,e){return Math.floor(t/2**e)}let Kl=class extends $w{constructor(){super(...arguments),this.maxBinNumber=0,this.depth=0,this.minShift=0}async lineCount(e,n){var r,o;return((o=(r=(await this.parse(n)).indices[e])===null||r===void 0?void 0:r.stats)===null||o===void 0?void 0:o.lineCount)||0}async indexCov(){return[]}parseAuxData(e,n){const r=e.readInt32LE(n),o=r&65536?"zero-based-half-open":"1-based-closed",i={0:"generic",1:"SAM",2:"VCF"}[r&15];if(!i)throw new Error(`invalid Tabix preset format flags ${r}`);const s={ref:e.readInt32LE(n+4),start:e.readInt32LE(n+8),end:e.readInt32LE(n+12)},a=e.readInt32LE(n+16),c=a?String.fromCharCode(a):"",l=e.readInt32LE(n+20),u=e.readInt32LE(n+24);return{columnNumbers:s,coordinateType:o,metaValue:a,metaChar:c,skipLines:l,format:i,formatFlags:r,...n9(e.subarray(n+28,n+28+u),this.renameRefSeq)}}async _parse(e){const n=await this.filehandle.readFile(e),r=await Or(n);let o;if(r.readUInt32LE(0)===u9)o=1;else if(r.readUInt32LE(0)===f9)o=2;else throw new Error("Not a CSI file");this.minShift=r.readInt32LE(4),this.depth=r.readInt32LE(8),this.maxBinNumber=((1<<(this.depth+1)*3)-1)/7;const i=r.readInt32LE(12),s=i>=30?this.parseAuxData(r,16):void 0,a=r.readInt32LE(16+i);let c=16+i+4,l;const u=new Array(a);for(let f=0;f<a;f++){const d=r.readInt32LE(c);c+=4;const h={};let p;for(let b=0;b<d;b++){const v=r.readUInt32LE(c);if(c+=4,v>this.maxBinNumber)p=Jw(r,c+28),c+=44;else{l=Xl(l,Co(r,c)),c+=8;const y=r.readInt32LE(c);c+=4;const A=new Array(y);for(let S=0;S<y;S+=1){const E=Co(r,c);c+=8;const I=Co(r,c);c+=8,l=Xl(l,E),A[S]=new zd(E,I,v)}h[v]=A}}u[f]={binIndex:h,stats:p}}return{csiVersion:o,firstDataLine:l,indices:u,refCount:a,csi:!0,maxBlockSize:65536,...s}}async blocksForRange(e,n,r,o={}){n<0&&(n=0);const s=(await this.parse(o)).indices[e];if(!s)return[];const a=this.reg2bins(n,r);if(a.length===0)return[];const c=[];for(const[l,u]of a)for(let f=l;f<=u;f++)if(s.binIndex[f]){const d=s.binIndex[f];for(const h of d)c.push(h)}return Kw(c,new Xw(0,0))}reg2bins(e,n){e-=1,e<1&&(e=1),n>2**50&&(n=2**34),n-=1;let r=0,o=0,i=this.minShift+this.depth*3;const s=[];for(;r<=this.depth;i-=3,o+=h9(1,r*3),r+=1){const a=o+tx(e,i),c=o+tx(n,i);if(c-a+s.length>this.maxBinNumber)throw new Error(`query ${e}-${n} is too large for current binning scheme (shift ${this.minShift}, depth ${this.depth}), try a smaller query or a coarser index binning scheme`);s.push([a,c])}return s}async parse(e={}){return this.setupP||(this.setupP=this._parse(e).catch(n=>{throw this.setupP=void 0,n})),this.setupP}async hasRefSeq(e,n={}){var r;return!!(!((r=(await this.parse(n)).indices[e])===null||r===void 0)&&r.binIndex)}};const gn={BAM_FPAIRED:1,BAM_FPROPER_PAIR:2,BAM_FUNMAP:4,BAM_FMUNMAP:8,BAM_FREVERSE:16,BAM_FMREVERSE:32,BAM_FREAD1:64,BAM_FREAD2:128,BAM_FSECONDARY:256,BAM_FQCFAIL:512,BAM_FDUP:1024,BAM_FSUPPLEMENTARY:2048},nx="=ACMGRSVTWYHKDBN".split(""),Ba="MIDNSHP=X???????".split("");class To{constructor(e){this.bytes=e.bytes,this.fileOffset=e.fileOffset}get byteArray(){return this.bytes.byteArray}get flags(){return(this.byteArray.readInt32LE(this.bytes.start+16)&4294901760)>>16}get ref_id(){return this.byteArray.readInt32LE(this.bytes.start+4)}get start(){return this.byteArray.readInt32LE(this.bytes.start+8)}get end(){return this.start+this.length_on_ref}get id(){return this.fileOffset}get mq(){const e=(this.bin_mq_nl&65280)>>8;return e===255?void 0:e}get score(){return this.mq}get qual(){if(this.isSegmentUnmapped())return;const e=this.b0+this.read_name_length+this.num_cigar_ops*4+this.num_seq_bytes;return this.byteArray.subarray(e,e+this.seq_length)}get strand(){return this.isReverseComplemented()?-1:1}get b0(){return this.bytes.start+36}get name(){return this.byteArray.toString("ascii",this.b0,this.b0+this.read_name_length-1)}get tags(){const{byteArray:e}=this.bytes;let n=this.b0+this.read_name_length+this.num_cigar_ops*4+this.num_seq_bytes+this.seq_length;const r=this.bytes.end,o={};for(;n<r;){const i=String.fromCharCode(e[n],e[n+1]),s=String.fromCharCode(e[n+2]);if(n+=3,s==="A")o[i]=String.fromCharCode(e[n]),n+=1;else if(s==="i")o[i]=e.readInt32LE(n),n+=4;else if(s==="I")o[i]=e.readUInt32LE(n),n+=4;else if(s==="c")o[i]=e.readInt8(n),n+=1;else if(s==="C")o[i]=e.readUInt8(n),n+=1;else if(s==="s")o[i]=e.readInt16LE(n),n+=2;else if(s==="S")o[i]=e.readUInt16LE(n),n+=2;else if(s==="f")o[i]=e.readFloatLE(n),n+=4;else if(s==="Z"||s==="H"){const a=[];for(;n<=r;){const c=e[n++];if(c!==0)a.push(String.fromCharCode(c));else break}o[i]=a.join("")}else if(s==="B"){const a=e[n++],c=String.fromCharCode(a),l=e.readInt32LE(n);if(n+=4,c==="i")if(i==="CG"){const u=[];for(let f=0;f<l;f++){const d=e.readInt32LE(n),h=d>>4,p=Ba[d&15];u.push(h+p),n+=4}o[i]=u.join("")}else{const u=[];for(let f=0;f<l;f++)u.push(e.readInt32LE(n)),n+=4;o[i]=u}else if(c==="I")if(i==="CG"){const u=[];for(let f=0;f<l;f++){const d=e.readUInt32LE(n),h=d>>4,p=Ba[d&15];u.push(h+p),n+=4}o[i]=u.join("")}else{const u=[];for(let f=0;f<l;f++)u.push(e.readUInt32LE(n)),n+=4;o[i]=u}else if(c==="s"){const u=[];for(let f=0;f<l;f++)u.push(e.readInt16LE(n)),n+=2;o[i]=u}else if(c==="S"){const u=[];for(let f=0;f<l;f++)u.push(e.readUInt16LE(n)),n+=2;o[i]=u}else if(c==="c"){const u=[];for(let f=0;f<l;f++)u.push(e.readInt8(n)),n+=1;o[i]=u}else if(c==="C"){const u=[];for(let f=0;f<l;f++)u.push(e.readUInt8(n)),n+=1;o[i]=u}else if(c==="f"){const u=[];for(let f=0;f<l;f++)u.push(e.readFloatLE(n)),n+=4;o[i]=u}}else{console.error("Unknown BAM tag type",s);break}}return o}isPaired(){return!!(this.flags&gn.BAM_FPAIRED)}isProperlyPaired(){return!!(this.flags&gn.BAM_FPROPER_PAIR)}isSegmentUnmapped(){return!!(this.flags&gn.BAM_FUNMAP)}isMateUnmapped(){return!!(this.flags&gn.BAM_FMUNMAP)}isReverseComplemented(){return!!(this.flags&gn.BAM_FREVERSE)}isMateReverseComplemented(){return!!(this.flags&gn.BAM_FMREVERSE)}isRead1(){return!!(this.flags&gn.BAM_FREAD1)}isRead2(){return!!(this.flags&gn.BAM_FREAD2)}isSecondary(){return!!(this.flags&gn.BAM_FSECONDARY)}isFailedQc(){return!!(this.flags&gn.BAM_FQCFAIL)}isDuplicate(){return!!(this.flags&gn.BAM_FDUP)}isSupplementary(){return!!(this.flags&gn.BAM_FSUPPLEMENTARY)}get cigarAndLength(){if(this.isSegmentUnmapped())return{length_on_ref:0,CIGAR:""};const e=this.num_cigar_ops;let n=this.b0+this.read_name_length;const r=[];let o=this.byteArray.readInt32LE(n),i=o>>4,s=Ba[o&15];if(s==="S"&&i===this.seq_length)return n+=4,o=this.byteArray.readInt32LE(n),i=o>>4,s=Ba[o&15],s!=="N"&&console.warn("CG tag with no N tag"),{CIGAR:this.tags.CG,length_on_ref:i};{let a=0;for(let c=0;c<e;++c)o=this.byteArray.readInt32LE(n),i=o>>4,s=Ba[o&15],r.push(i+s),s!=="H"&&s!=="S"&&s!=="I"&&(a+=i),n+=4;return{CIGAR:r.join(""),length_on_ref:a}}}get length_on_ref(){return this.cigarAndLength.length_on_ref}get CIGAR(){return this.cigarAndLength.CIGAR}get num_cigar_ops(){return this.flag_nc&65535}get read_name_length(){return this.bin_mq_nl&255}get num_seq_bytes(){return this.seq_length+1>>1}get seq(){const{byteArray:e}=this.bytes,n=this.b0+this.read_name_length+this.num_cigar_ops*4,r=this.num_seq_bytes,o=this.seq_length,i=[];let s=0;for(let a=0;a<r;++a){const c=e[n+a];i.push(nx[(c&240)>>4]),s++,s<o&&(i.push(nx[c&15]),s++)}return i.join("")}get pair_orientation(){if(!this.isSegmentUnmapped()&&!this.isMateUnmapped()&&this.ref_id===this.next_refid){const e=this.isReverseComplemented()?"R":"F",n=this.isMateReverseComplemented()?"R":"F";let r=" ",o=" ";this.isRead1()?(r="1",o="2"):this.isRead2()&&(r="2",o="1");const i=[];return this.template_length>0?(i[0]=e,i[1]=r,i[2]=n,i[3]=o):(i[2]=e,i[3]=r,i[0]=n,i[1]=o),i.join("")}}get bin_mq_nl(){return this.byteArray.readInt32LE(this.bytes.start+12)}get flag_nc(){return this.byteArray.readInt32LE(this.bytes.start+16)}get seq_length(){return this.byteArray.readInt32LE(this.bytes.start+20)}get next_refid(){return this.byteArray.readInt32LE(this.bytes.start+24)}get next_pos(){return this.byteArray.readInt32LE(this.bytes.start+28)}get template_length(){return this.byteArray.readInt32LE(this.bytes.start+32)}toJSON(){const e={};for(const n of Object.keys(this))n.startsWith("_")||n==="bytes"||(e[n]=this[n]);return e}}function Jl(t,e){const n=Object.getOwnPropertyDescriptor(t.prototype,e);if(!n)throw new Error("OH NO, NO PROPERTY DESCRIPTOR");const r=n.get;if(!r)throw new Error("OH NO, NOT A GETTER");Object.defineProperty(t.prototype,e,{get(){const o=r.call(this);return Object.defineProperty(this,e,{value:o}),o}})}Jl(To,"tags"),Jl(To,"cigarAndLength"),Jl(To,"seq"),Jl(To,"qual");function rx(t){const e=t.split(/\r?\n/),n=[];for(const r of e){const[o,...i]=r.split(/\t/);o&&n.push({tag:o.slice(1),data:i.map(s=>{const a=s.indexOf(":"),c=s.slice(0,a),l=s.slice(a+1);return{tag:c,value:l}})})}return n}const ix=21840194,ox=65536;async function d9(t){let e=[];for await(const n of t)e=e.concat(n);return e}class p9{read(){throw new Error("never called")}stat(){throw new Error("never called")}readFile(){throw new Error("never called")}close(){throw new Error("never called")}}class sx{constructor({bamFilehandle:e,bamPath:n,bamUrl:r,baiPath:o,baiFilehandle:i,baiUrl:s,csiPath:a,csiFilehandle:c,csiUrl:l,htsget:u,yieldThreadTime:f=100,renameRefSeqs:d=h=>h}){if(this.htsget=!1,this.featureCache=new Ei({cache:new zl({maxSize:50}),fill:async(h,p)=>{const{chunk:b,opts:v}=h,{data:y,cpositions:A,dpositions:S}=await this._readChunk({chunk:b,opts:{...v,signal:p}});return this.readBamFeatures(y,A,S,b)}}),this.renameRefSeq=d,e)this.bam=e;else if(n)this.bam=new Ct(n);else if(r)this.bam=new Cn(r);else if(u)this.htsget=!0,this.bam=new p9;else throw new Error("unable to initialize bam");if(c)this.index=new Kl({filehandle:c});else if(a)this.index=new Kl({filehandle:new Ct(a)});else if(l)this.index=new Kl({filehandle:new Cn(l)});else if(i)this.index=new Io({filehandle:i});else if(o)this.index=new Io({filehandle:new Ct(o)});else if(s)this.index=new Io({filehandle:new Cn(s)});else if(n)this.index=new Io({filehandle:new Ct(`${n}.bai`)});else if(r)this.index=new Io({filehandle:new Cn(`${r}.bai`)});else if(u)this.htsget=!0;else throw new Error("unable to infer index format");this.yieldThreadTime=f}async getHeaderPre(e){const n=t9(e);if(!this.index)return;const r=await this.index.parse(n),o=r.firstDataLine?r.firstDataLine.blockPosition+65535:void 0;let i;if(o){const u=o+ox,f=await this.bam.read(Ke.Buffer.alloc(u),0,u,0,n);if(!f.bytesRead)throw new Error("Error reading header");i=f.buffer.subarray(0,Math.min(f.bytesRead,o))}else i=await this.bam.readFile(n);const s=await Or(i);if(s.readInt32LE(0)!==ix)throw new Error("Not a BAM file");const a=s.readInt32LE(4);this.header=s.toString("utf8",8,8+a);const{chrToIndex:c,indexToChr:l}=await this._readRefSeqs(a+8,65535,n);return this.chrToIndex=c,this.indexToChr=l,rx(this.header)}getHeader(e){return this.headerP||(this.headerP=this.getHeaderPre(e).catch(n=>{throw this.headerP=void 0,n})),this.headerP}async getHeaderText(e={}){return await this.getHeader(e),this.header}async _readRefSeqs(e,n,r){if(e>n)return this._readRefSeqs(e,n*2,r);const o=n+ox,{bytesRead:i,buffer:s}=await this.bam.read(Ke.Buffer.alloc(o),0,n,0,r);if(!i)throw new Error("Error reading refseqs from header");const a=await Or(s.subarray(0,Math.min(i,n))),c=a.readInt32LE(e);let l=e+4;const u={},f=[];for(let d=0;d<c;d+=1){const h=a.readInt32LE(l),p=this.renameRefSeq(a.toString("utf8",l+4,l+4+h-1)),b=a.readInt32LE(l+h+4);if(u[p]=d,f.push({refName:p,length:b}),l=l+8+h,l>a.length)return console.warn(`BAM header is very big. Re-fetching ${n} bytes.`),this._readRefSeqs(e,n*2,r)}return{chrToIndex:u,indexToChr:f}}async getRecordsForRange(e,n,r,o){return d9(this.streamRecordsForRange(e,n,r,o))}async*streamRecordsForRange(e,n,r,o){var i;await this.getHeader(o);const s=(i=this.chrToIndex)===null||i===void 0?void 0:i[e];if(s===void 0||!this.index)yield[];else{const a=await this.index.blocksForRange(s,n-1,r,o);yield*this._fetchChunkFeatures(a,s,n,r,o)}}async*_fetchChunkFeatures(e,n,r,o,i={}){const{viewAsPairs:s}=i,a=[];let c=!1;for(const l of e){const u=await this.featureCache.get(l.toString(),{chunk:l,opts:i},i.signal),f=[];for(const d of u)if(d.ref_id===n)if(d.start>=o){c=!0;break}else d.end>=r&&f.push(d);if(a.push(f),yield f,c)break}$F(i.signal),s&&(yield this.fetchPairs(n,a,i))}async fetchPairs(e,n,r){const{pairAcrossChr:o,maxInsertSize:i=2e5}=r,s={},a={};n.map(d=>{const h={};for(const p of d){const b=p.name,v=p.id;h[b]||(h[b]=0),h[b]++,a[v]=1}for(const[p,b]of Object.entries(h))b===1&&(s[p]=!0)});const c=[];n.map(d=>{for(const h of d){const p=h.name,b=h.start,v=h.next_pos,y=h.next_refid;this.index&&s[p]&&(o||y===e&&Math.abs(b-v)<i)&&c.push(this.index.blocksForRange(y,v,v+1,r))}});const l=new Map,u=await Promise.all(c);for(const d of u.flat())l.has(d.toString())||l.set(d.toString(),d);return(await Promise.all([...l.values()].map(async d=>{const{data:h,cpositions:p,dpositions:b,chunk:v}=await this._readChunk({chunk:d,opts:r}),y=[];for(const A of await this.readBamFeatures(h,p,b,v))s[A.name]&&!a[A.id]&&y.push(A);return y}))).flat()}async _readRegion(e,n,r={}){const{bytesRead:o,buffer:i}=await this.bam.read(Ke.Buffer.alloc(n),0,n,e,r);return i.subarray(0,Math.min(o,n))}async _readChunk({chunk:e,opts:n}){const r=await this._readRegion(e.minv.blockPosition,e.fetchedSize(),n),{buffer:o,cpositions:i,dpositions:s}=await m2(r,e);return{data:o,cpositions:i,dpositions:s,chunk:e}}async readBamFeatures(e,n,r,o){let i=0;const s=[];let a=0,c=+Date.now();for(;i+4<e.length;){const l=e.readInt32LE(i),u=i+4+l-1;if(r){for(;i+o.minv.dataPosition>=r[a++];);a--}if(u<e.length){const f=new To({bytes:{byteArray:e,start:i,end:u},fileOffset:n.length>0?n[a]*256+(i-r[a])+o.minv.dataPosition+1:l9.signed(e.slice(i,u))});s.push(f),this.yieldThreadTime&&+Date.now()-c>this.yieldThreadTime&&(await JF(1),c=+Date.now())}i=u+1}return s}async hasRefSeq(e){var n,r;const o=(n=this.chrToIndex)===null||n===void 0?void 0:n[e];return o===void 0?!1:(r=this.index)===null||r===void 0?void 0:r.hasRefSeq(o)}async lineCount(e){var n;const r=(n=this.chrToIndex)===null||n===void 0?void 0:n[e];return r===void 0||!this.index?0:this.index.lineCount(r)}async indexCov(e,n,r){var o;if(!this.index)return[];await this.index.parse();const i=(o=this.chrToIndex)===null||o===void 0?void 0:o[e];return i===void 0?[]:this.index.indexCov(i,n,r)}async blocksForRange(e,n,r,o){var i;if(!this.index)return[];await this.index.parse();const s=(i=this.chrToIndex)===null||i===void 0?void 0:i[e];return s===void 0?[]:this.index.blocksForRange(s,n,r,o)}}async function ax(t,e){const n=await Promise.all(t.map(async r=>{const{url:o,headers:i}=r;if(o.startsWith("data:"))return Ke.Buffer.from(o.split(",")[1],"base64");{const{referer:s,...a}=i,c=await fetch(o,{...e,headers:{...e==null?void 0:e.headers,...a}});if(!c.ok)throw new Error(`HTTP ${c.status} fetching ${o}: ${await c.text()}`);return Ke.Buffer.from(await c.arrayBuffer())}}));return Ke.Buffer.concat(await Promise.all(n.map(r=>Or(r))))}class g9 extends sx{constructor(e){super({htsget:!0}),this.baseUrl=e.baseUrl,this.trackId=e.trackId}async*streamRecordsForRange(e,n,r,o){var i;const a=`${`${this.baseUrl}/${this.trackId}`}?referenceName=${e}&start=${n}&end=${r}&format=BAM`,c=(i=this.chrToIndex)===null||i===void 0?void 0:i[e];if(c===void 0)yield[];else{const l=await fetch(a,{...o});if(!l.ok)throw new Error(`HTTP ${l.status} fetching ${a}: ${await l.text()}`);const u=await l.json(),f=await ax(u.htsget.urls.slice(1),o);yield*this._fetchChunkFeatures([{buffer:f,_fetchedSize:void 0,bin:0,compareTo(){return 0},toUniqueString(){return`${e}_${n}_${r}`},fetchedSize(){return 0},minv:{dataPosition:0,blockPosition:0,compareTo:()=>0},maxv:{dataPosition:Number.MAX_SAFE_INTEGER,blockPosition:0,compareTo:()=>0},toString(){return`${e}_${n}_${r}`}}],c,n,r,o)}}async _readChunk({chunk:e}){if(!e.buffer)throw new Error("expected chunk.buffer in htsget");return{data:e.buffer,cpositions:[],dpositions:[],chunk:e}}async getHeader(e={}){const n=`${this.baseUrl}/${this.trackId}?referenceName=na&class=header`,r=await fetch(n,e);if(!r.ok)throw new Error(`HTTP ${r.status} fetching ${n}: ${await r.text()}`);const o=await r.json(),i=await ax(o.htsget.urls,e);if(i.readInt32LE(0)!==ix)throw new Error("Not a BAM file");const s=i.readInt32LE(4),a=i.toString("utf8",8,8+s),c=rx(a),l=[],u={},f=c.filter(d=>d.tag==="SQ");for(const[d,h]of f.entries()){let p="",b=0;for(const v of h.data)v.tag==="SN"?p=v.value:v.tag==="LN"&&(b=+v.value);u[p]=d,l[d]={refName:p,length:b}}return this.chrToIndex=u,this.indexToChr=l,c}}const m9=Object.freeze(Object.defineProperty({__proto__:null,BAI:Io,BamFile:sx,BamRecord:To,CSI:Kl,HtsgetFile:g9},Symbol.toStringTag,{value:"Module"}));function cx(t){if(t.greaterThan(Number.MAX_SAFE_INTEGER)||t.lessThan(Number.MIN_SAFE_INTEGER))throw new Error("integer overflow");return t.toNumber()}class b9 extends Error{}function ka(t){if(t&&t.aborted){if(typeof DOMException<"u")throw new DOMException("aborted","AbortError");{const e=new b9("aborted");throw e.code="ERR_ABORTED",e}}}function y9(t,e){return e.minv.blockPosition-t.maxv.blockPosition<65e3&&e.maxv.blockPosition-t.minv.blockPosition<5e6}function lx(t,e){const n=[];let r=null;return t.length===0?t:(t.sort(function(o,i){const s=o.minv.blockPosition-i.minv.blockPosition;return s!==0?s:o.minv.dataPosition-i.minv.dataPosition}),t.forEach(o=>{(!e||o.maxv.compareTo(e)>0)&&(r===null?(n.push(o),r=o):y9(r,o)?o.maxv.compareTo(r.maxv)>0&&(r.maxv=o.maxv):(n.push(o),r=o))}),n)}class Gd{constructor(e,n){this.blockPosition=e,this.dataPosition=n}toString(){return`${this.blockPosition}:${this.dataPosition}`}compareTo(e){return this.blockPosition-e.blockPosition||this.dataPosition-e.dataPosition}}function Do(t,e=0,n=!1){if(n)throw new Error("big-endian virtual file offsets not implemented");return new Gd(t[e+7]*1099511627776+t[e+6]*4294967296+t[e+5]*16777216+t[e+4]*65536+t[e+3]*256+t[e+2],t[e+1]<<8|t[e])}class $l{constructor(e,n,r,o=void 0){this.minv=e,this.maxv=n,this.bin=r,this._fetchedSize=o}toUniqueString(){return`${this.minv}..${this.maxv} (bin ${this.bin}, fetchedSize ${this.fetchedSize()})`}toString(){return this.toUniqueString()}compareTo(e){return this.minv.compareTo(e.minv)||this.maxv.compareTo(e.maxv)||this.bin-e.bin}fetchedSize(){return this._fetchedSize!==void 0?this._fetchedSize:this.maxv.blockPosition+65536-this.minv.blockPosition}}class ux{constructor({filehandle:e,renameRefSeqs:n=r=>r}){this.filehandle=e,this.renameRefSeq=n}async getMetadata(e={}){const{indices:n,...r}=await this.parse(e);return r}_findFirstData(e,n){return e?e.compareTo(n)>0?n:e:n}async parse(e={}){return this.parseP||(this.parseP=this._parse(e).catch(n=>{throw this.parseP=void 0,n})),this.parseP}async hasRefSeq(e,n={}){var r;return!!(!((r=(await this.parse(n)).indices[e])===null||r===void 0)&&r.binIndex)}}const w9=21578324,fx=14;function x9(t,e){return t+=1,e-=1,[[0,0],[1+(t>>26),1+(e>>26)],[9+(t>>23),9+(e>>23)],[73+(t>>20),73+(e>>20)],[585+(t>>17),585+(e>>17)],[4681+(t>>14),4681+(e>>14)]]}class Bo extends ux{async lineCount(e,n={}){const r=await this.parse(n),o=r.refNameToId[e];if(o===void 0||!r.indices[o])return-1;const{stats:s}=r.indices[o];return s?s.lineCount:-1}async _parse(e={}){const n=await this.filehandle.readFile(e),r=await Or(n);if(ka(e.signal),r.readUInt32LE(0)!==w9)throw new Error("Not a TBI file");const o=r.readInt32LE(4),i=r.readInt32LE(8),s=i&65536?"zero-based-half-open":"1-based-closed",c={0:"generic",1:"SAM",2:"VCF"}[i&15];if(!c)throw new Error(`invalid Tabix preset format flags ${i}`);const l={ref:r.readInt32LE(12),start:r.readInt32LE(16),end:r.readInt32LE(20)},u=r.readInt32LE(24),f=5,d=((1<<(f+1)*3)-1)/7,h=2**(14+f*3),p=u?String.fromCharCode(u):null,b=r.readInt32LE(28),v=r.readInt32LE(32),{refNameToId:y,refIdToName:A}=this._parseNameBytes(r.slice(36,36+v));let S=36+v,E;return{indices:new Array(o).fill(0).map(()=>{const _=r.readInt32LE(S);S+=4;const B={};let N;for(let C=0;C<_;C+=1){const Y=r.readUInt32LE(S);if(S+=4,Y>d+1)throw new Error("tabix index contains too many bins, please use a CSI index");if(Y===d+1){const Q=r.readInt32LE(S);S+=4,Q===2&&(N=this.parsePseudoBin(r,S)),S+=16*Q}else{const Q=r.readInt32LE(S);S+=4;const se=new Array(Q);for(let oe=0;oe<Q;oe+=1){const ae=Do(r,S),ce=Do(r,S+8);S+=16,E=this._findFirstData(E,ae),se[oe]=new $l(ae,ce,Y)}B[Y]=se}}const M=r.readInt32LE(S);S+=4;const F=new Array(M);for(let C=0;C<M;C+=1)F[C]=Do(r,S),S+=8,E=this._findFirstData(E,F[C]);return{binIndex:B,linearIndex:F,stats:N}}),metaChar:p,maxBinNumber:d,maxRefLength:h,skipLines:b,firstDataLine:E,columnNumbers:l,coordinateType:s,format:c,refIdToName:A,refNameToId:y,maxBlockSize:65536}}parsePseudoBin(e,n){return{lineCount:cx(Ol.fromBytesLE(e.slice(n+16,n+24),!0))}}_parseNameBytes(e){let n=0,r=0;const o=[],i={};for(let s=0;s<e.length;s+=1)if(!e[s]){if(r<s){let a=e.toString("utf8",r,s);a=this.renameRefSeq(a),o[n]=a,i[a]=n}r=s+1,n+=1}return{refNameToId:i,refIdToName:o}}async blocksForRange(e,n,r,o={}){n<0&&(n=0);const i=await this.parse(o),s=i.refNameToId[e];if(s===void 0)return[];const a=i.indices[s];if(!a)return[];(a.linearIndex.length?a.linearIndex[n>>fx>=a.linearIndex.length?a.linearIndex.length-1:n>>fx]:new Gd(0,0))||console.warn("querying outside of possible tabix range");const l=x9(n,r),u=[];for(const[b,v]of l)for(let y=b;y<=v;y++)if(a.binIndex[y])for(const A of a.binIndex[y])u.push(new $l(A.minv,A.maxv,y));const f=a.linearIndex.length;let d=null;const h=Math.min(n>>14,f-1),p=Math.min(r>>14,f-1);for(let b=h;b<=p;++b){const v=a.linearIndex[b];v&&(!d||v.compareTo(d)<0)&&(d=v)}return lx(u,d)}}const v9=21582659,A9=38359875;function E9(t,e){return t*2**e}function hx(t,e){return Math.floor(t/2**e)}class eu extends ux{constructor(e){super(e),this.maxBinNumber=0,this.depth=0,this.minShift=0}async lineCount(e,n={}){const r=await this.parse(n),o=r.refNameToId[e];if(o===void 0||!r.indices[o])return-1;const{stats:s}=r.indices[o];return s?s.lineCount:-1}indexCov(){throw new Error("CSI indexes do not support indexcov")}parseAuxData(e,n){const r=e.readInt32LE(n),o=r&65536?"zero-based-half-open":"1-based-closed",i={0:"generic",1:"SAM",2:"VCF"}[r&15];if(!i)throw new Error(`invalid Tabix preset format flags ${r}`);const s={ref:e.readInt32LE(n+4),start:e.readInt32LE(n+8),end:e.readInt32LE(n+12)},a=e.readInt32LE(n+16),c=a?String.fromCharCode(a):null,l=e.readInt32LE(n+20),u=e.readInt32LE(n+24),{refIdToName:f,refNameToId:d}=this._parseNameBytes(e.slice(n+28,n+28+u));return{refIdToName:f,refNameToId:d,skipLines:l,metaChar:c,columnNumbers:s,format:i,coordinateType:o}}_parseNameBytes(e){let n=0,r=0;const o=[],i={};for(let s=0;s<e.length;s+=1)if(!e[s]){if(r<s){let a=e.toString("utf8",r,s);a=this.renameRefSeq(a),o[n]=a,i[a]=n}r=s+1,n+=1}return{refNameToId:i,refIdToName:o}}async _parse(e={}){const n=await Or(await this.filehandle.readFile(e));let r;if(n.readUInt32LE(0)===v9)r=1;else if(n.readUInt32LE(0)===A9)r=2;else throw new Error("Not a CSI file");this.minShift=n.readInt32LE(4),this.depth=n.readInt32LE(8),this.maxBinNumber=((1<<(this.depth+1)*3)-1)/7;const o=2**(this.minShift+this.depth*3),i=n.readInt32LE(12),s=i&&i>=30?this.parseAuxData(n,16):{refIdToName:[],refNameToId:{},metaChar:null,columnNumbers:{ref:0,start:1,end:2},coordinateType:"zero-based-half-open",format:"generic"},a=n.readInt32LE(16+i);let c,l=16+i+4;const u=new Array(a).fill(0).map(()=>{const f=n.readInt32LE(l);l+=4;const d={};let h;for(let p=0;p<f;p+=1){const b=n.readUInt32LE(l);if(b>this.maxBinNumber)h=this.parsePseudoBin(n,l+4),l+=48;else{const v=Do(n,l+4);c=this._findFirstData(c,v);const y=n.readInt32LE(l+12);l+=16;const A=new Array(y);for(let S=0;S<y;S+=1){const E=Do(n,l),I=Do(n,l+8);l+=16,A[S]=new $l(E,I,b)}d[b]=A}}return{binIndex:d,stats:h}});return{...s,csi:!0,refCount:a,maxBlockSize:65536,firstDataLine:c,csiVersion:r,indices:u,depth:this.depth,maxBinNumber:this.maxBinNumber,maxRefLength:o}}parsePseudoBin(e,n){return{lineCount:cx(Ol.fromBytesLE(e.slice(n+28,n+36),!0))}}async blocksForRange(e,n,r,o={}){n<0&&(n=0);const i=await this.parse(o),s=i.refNameToId[e];if(s===void 0)return[];const a=i.indices[s];if(!a)return[];const c=this.reg2bins(n,r),l=[];for(const[u,f]of c)for(let d=u;d<=f;d++)if(a.binIndex[d])for(const h of a.binIndex[d])l.push(new $l(h.minv,h.maxv,d));return lx(l,new Gd(0,0))}reg2bins(e,n){e-=1,e<1&&(e=1),n>2**50&&(n=2**34),n-=1;let r=0,o=0,i=this.minShift+this.depth*3;const s=[];for(;r<=this.depth;i-=3,o+=E9(1,r*3),r+=1){const a=o+hx(e,i),c=o+hx(n,i);if(c-a+s.length>this.maxBinNumber)throw new Error(`query ${e}-${n} is too large for current binning scheme (shift ${this.minShift}, depth ${this.depth}), try a smaller query or a coarser index binning scheme`);s.push([a,c])}return s}}function S9(t){return/^[\u0000-\u007F]*$/.test(t)}const ko=typeof TextDecoder<"u"?new TextDecoder("utf8"):void 0;class C9{constructor({path:e,filehandle:n,url:r,tbiPath:o,tbiUrl:i,tbiFilehandle:s,csiPath:a,csiUrl:c,csiFilehandle:l,renameRefSeqs:u=d=>d,chunkCacheSize:f=5*2**20}){if(n)this.filehandle=n;else if(e)this.filehandle=new Ct(e);else if(r)this.filehandle=new Cn(r);else throw new TypeError("must provide either filehandle or path");if(s)this.index=new Bo({filehandle:s,renameRefSeqs:u});else if(l)this.index=new eu({filehandle:l,renameRefSeqs:u});else if(o)this.index=new Bo({filehandle:new Ct(o),renameRefSeqs:u});else if(a)this.index=new eu({filehandle:new Ct(a),renameRefSeqs:u});else if(e)this.index=new Bo({filehandle:new Ct(`${e}.tbi`),renameRefSeqs:u});else if(c)this.index=new eu({filehandle:new Cn(c)});else if(i)this.index=new Bo({filehandle:new Cn(i)});else if(r)this.index=new Bo({filehandle:new Cn(`${r}.tbi`)});else throw new TypeError("must provide one of tbiFilehandle, tbiPath, csiFilehandle, csiPath, tbiUrl, csiUrl");this.renameRefSeq=u,this.chunkCache=new Ei({cache:new zl({maxSize:Math.floor(f/65536)}),fill:(d,h)=>this.readChunk(d,{signal:h})})}async getLines(e,n,r,o){var i,s;let a,c={},l;typeof o=="function"?l=o:(c=o,l=o.lineCallback,a=o.signal);const u=await this.index.getMetadata(c);ka(a);const f=n??0,d=r??u.maxRefLength;if(!(f<=d))throw new TypeError("invalid start and end coordinates. start must be less than or equal to end");if(f===d)return;const h=await this.index.blocksForRange(e,f,d,c);ka(a);for(const p of h){const{buffer:b,cpositions:v,dpositions:y}=await this.chunkCache.get(p.toString(),p,a);ka(a);let A=0,S=0;const E=(i=ko==null?void 0:ko.decode(b))!==null&&i!==void 0?i:b.toString(),I=b.length<5e8&&S9(E);for(;A<E.length;){let _,B;if(I){if(B=E.indexOf(`
|
|
814
|
+
)`},Symbol.toStringTag,{value:"Module"}))).map(([t,e])=>[t,Zw.parse(e.trim())]));function Nd(t){const e=new Set(["uint","int","float","long"]);return{...t,fields:t.fields.map(n=>({...n,isArray:n.size&&n.type!=="char",arrayIsNumeric:n.size&&e.has(n.type),isNumeric:!n.size&&e.has(n.type)})).filter(n=>!!n.name)}}const QF={".":0,"-":-1,"+":1};function ZF(t){var e;return t.length>=12&&!Number.isNaN(parseInt(t[9],10))&&((e=t[10])===null||e===void 0?void 0:e.split(",").filter(n=>!!n).length)===parseInt(t[9],10)}class XF{constructor(e={}){if(e.autoSql)this.autoSql=Nd(YF.parse(e.autoSql));else if(e.type){if(!Od[e.type])throw new Error("Type not found");this.autoSql=Nd(Od[e.type])}else this.autoSql=Nd(Od.defaultBedSchema),this.attemptDefaultBed=!0}parseLine(e,n={}){const{autoSql:r}=this,{uniqueId:o}=n,i=Array.isArray(e)?e:e.split(" ");let s={};if(!this.attemptDefaultBed||this.attemptDefaultBed&&ZF(i))for(let a=0;a<r.fields.length;a++){const c=r.fields[a];let l=i[a];const{isNumeric:u,isArray:f,arrayIsNumeric:d,name:h}=c;if(l==null)break;if(l!=="."){if(u){const p=Number(l);l=Number.isNaN(p)?l:p}else f&&(l=l.split(","),l[l.length-1]===""&&l.pop(),d&&(l=l.map(Number)));s[h]=l}}else{const a=["chrom","chromStart","chromEnd","name"];s=Object.fromEntries(i.map((c,l)=>[a[l]||"field"+l,c])),s.chromStart=+s.chromStart,s.chromEnd=+s.chromEnd,Number.isNaN(Number.parseFloat(s.field4))||(s.score=+s.field4,delete s.field4),(s.field5==="+"||s.field5==="-")&&(s.strand=s.field5,delete s.field5)}return o&&(s.uniqueId=o),s.strand=QF[s.strand]||0,s.chrom=decodeURIComponent(s.chrom),s}}const KF=Object.freeze(Object.defineProperty({__proto__:null,default:XF},Symbol.toStringTag,{value:"Module"}));let Xw=class{constructor(e,n){this.blockPosition=e,this.dataPosition=n}toString(){return`${this.blockPosition}:${this.dataPosition}`}compareTo(e){return this.blockPosition-e.blockPosition||this.dataPosition-e.dataPosition}static min(...e){let n,r=0;for(;!n;r+=1)n=e[r];for(;r<e.length;r+=1)n.compareTo(e[r])>0&&(n=e[r]);return n}};function Co(t,e=0,n=!1){if(n)throw new Error("big-endian virtual file offsets not implemented");return new Xw(t[e+7]*1099511627776+t[e+6]*4294967296+t[e+5]*16777216+t[e+4]*65536+t[e+3]*256+t[e+2],t[e+1]<<8|t[e])}let zd=class{constructor(e,n,r,o){this.minv=e,this.maxv=n,this.bin=r,this._fetchedSize=o}toUniqueString(){return`${this.minv.toString()}..${this.maxv.toString()} (bin ${this.bin}, fetchedSize ${this.fetchedSize()})`}toString(){return this.toUniqueString()}compareTo(e){return this.minv.compareTo(e.minv)||this.maxv.compareTo(e.maxv)||this.bin-e.bin}fetchedSize(){return this._fetchedSize!==void 0?this._fetchedSize:this.maxv.blockPosition+65536-this.minv.blockPosition}};function JF(t){return new Promise(e=>setTimeout(e,t))}function $F(t){if(t&&t.aborted)if(typeof DOMException>"u"){const e=new Error("aborted");throw e.code="ERR_ABORTED",e}else throw new DOMException("aborted","AbortError")}function e9(t,e){return e.minv.blockPosition-t.maxv.blockPosition<65e3&&e.maxv.blockPosition-t.minv.blockPosition<5e6}function t9(t={}){return"aborted"in t?{signal:t}:t}function Kw(t,e){const n=[];let r;if(t.length===0)return t;t.sort((o,i)=>{const s=o.minv.blockPosition-i.minv.blockPosition;return s===0?o.minv.dataPosition-i.minv.dataPosition:s});for(const o of t)(!e||o.maxv.compareTo(e)>0)&&(r===void 0?(n.push(o),r=o):e9(r,o)?o.maxv.compareTo(r.maxv)>0&&(r.maxv=o.maxv):(n.push(o),r=o));return n}function Jw(t,e){return{lineCount:Ol.fromBytesLE(Array.prototype.slice.call(t,e,e+8),!0).toNumber()}}function Xl(t,e){return t?t.compareTo(e)>0?e:t:e}function n9(t,e=n=>n){let n=0,r=0;const o=[],i={};for(let s=0;s<t.length;s+=1)if(!t[s]){if(r<s){let a=t.toString("utf8",r,s);a=e(a),o[n]=a,i[a]=n}r=s+1,n+=1}return{refNameToId:i,refIdToName:o}}let $w=class{constructor({filehandle:e,renameRefSeq:n=r=>r}){this.filehandle=e,this.renameRefSeq=n}};const r9=21578050;function i9(t,e){return t-t%e}function o9(t,e){return t-t%e+e}function s9(t,e){return e-=1,[[0,0],[1+(t>>26),1+(e>>26)],[9+(t>>23),9+(e>>23)],[73+(t>>20),73+(e>>20)],[585+(t>>17),585+(e>>17)],[4681+(t>>14),4681+(e>>14)]]}class Io extends $w{async lineCount(e,n){var r,o;return((o=(r=(await this.parse(n)).indices[e])===null||r===void 0?void 0:r.stats)===null||o===void 0?void 0:o.lineCount)||0}async _parse(e){const n=await this.filehandle.readFile(e);if(n.readUInt32LE(0)!==r9)throw new Error("Not a BAI file");const r=n.readInt32LE(4),i=((1<<(5+1)*3)-1)/7;let s=8,a;const c=new Array(r);for(let l=0;l<r;l++){const u=n.readInt32LE(s);let f;s+=4;const d={};for(let b=0;b<u;b+=1){const v=n.readUInt32LE(s);if(s+=4,v===i+1)s+=4,f=Jw(n,s+16),s+=32;else{if(v>i+1)throw new Error("bai index contains too many bins, please use CSI");{const y=n.readInt32LE(s);s+=4;const A=new Array(y);for(let S=0;S<y;S++){const E=Co(n,s);s+=8;const I=Co(n,s);s+=8,a=Xl(a,E),A[S]=new zd(E,I,v)}d[v]=A}}}const h=n.readInt32LE(s);s+=4;const p=new Array(h);for(let b=0;b<h;b++){const v=Co(n,s);s+=8,a=Xl(a,v),p[b]=v}c[l]={binIndex:d,linearIndex:p,stats:f}}return{bai:!0,firstDataLine:a,maxBlockSize:65536,indices:c,refCount:r}}async indexCov(e,n,r,o={}){const s=n!==void 0,c=(await this.parse(o)).indices[e];if(!c)return[];const{linearIndex:l=[],stats:u}=c;if(l.length===0)return[];const f=r===void 0?(l.length-1)*16384:o9(r,16384),d=n===void 0?0:i9(n,16384),h=s?new Array((f-d)/16384):new Array(l.length-1),p=l[l.length-1].blockPosition;if(f>(l.length-1)*16384)throw new Error("query outside of range of linear index");let b=l[d/16384].blockPosition;for(let v=d/16384,y=0;v<f/16384;v++,y++)h[y]={score:l[v+1].blockPosition-b,start:v*16384,end:v*16384+16384},b=l[v+1].blockPosition;return h.map(v=>({...v,score:v.score*((u==null?void 0:u.lineCount)||0)/p}))}async blocksForRange(e,n,r,o={}){n<0&&(n=0);const i=await this.parse(o);if(!i)return[];const s=i.indices[e];if(!s)return[];const a=s9(n,r),c=[];for(const[h,p]of a)for(let b=h;b<=p;b++)if(s.binIndex[b]){const v=s.binIndex[b];for(const y of v)c.push(new zd(y.minv,y.maxv,b))}const l=s.linearIndex.length;let u;const f=Math.min(n>>14,l-1),d=Math.min(r>>14,l-1);for(let h=f;h<=d;++h){const p=s.linearIndex[h];p&&(!u||p.compareTo(u)<0)&&(u=p)}return Kw(c,u)}async parse(e={}){return this.setupP||(this.setupP=this._parse(e).catch(n=>{throw this.setupP=void 0,n})),this.setupP}async hasRefSeq(e,n={}){var r;return!!(!((r=(await this.parse(n)).indices[e])===null||r===void 0)&&r.binIndex)}}let Ud=[0,1996959894,3993919788,2567524794,124634137,1886057615,3915621685,2657392035,249268274,2044508324,3772115230,2547177864,162941995,2125561021,3887607047,2428444049,498536548,1789927666,4089016648,2227061214,450548861,1843258603,4107580753,2211677639,325883990,1684777152,4251122042,2321926636,335633487,1661365465,4195302755,2366115317,997073096,1281953886,3579855332,2724688242,1006888145,1258607687,3524101629,2768942443,901097722,1119000684,3686517206,2898065728,853044451,1172266101,3705015759,2882616665,651767980,1373503546,3369554304,3218104598,565507253,1454621731,3485111705,3099436303,671266974,1594198024,3322730930,2970347812,795835527,1483230225,3244367275,3060149565,1994146192,31158534,2563907772,4023717930,1907459465,112637215,2680153253,3904427059,2013776290,251722036,2517215374,3775830040,2137656763,141376813,2439277719,3865271297,1802195444,476864866,2238001368,4066508878,1812370925,453092731,2181625025,4111451223,1706088902,314042704,2344532202,4240017532,1658658271,366619977,2362670323,4224994405,1303535960,984961486,2747007092,3569037538,1256170817,1037604311,2765210733,3554079995,1131014506,879679996,2909243462,3663771856,1141124467,855842277,2852801631,3708648649,1342533948,654459306,3188396048,3373015174,1466479909,544179635,3110523913,3462522015,1591671054,702138776,2966460450,3352799412,1504918807,783551873,3082640443,3233442989,3988292384,2596254646,62317068,1957810842,3939845945,2647816111,81470997,1943803523,3814918930,2489596804,225274430,2053790376,3826175755,2466906013,167816743,2097651377,4027552580,2265490386,503444072,1762050814,4150417245,2154129355,426522225,1852507879,4275313526,2312317920,282753626,1742555852,4189708143,2394877945,397917763,1622183637,3604390888,2714866558,953729732,1340076626,3518719985,2797360999,1068828381,1219638859,3624741850,2936675148,906185462,1090812512,3747672003,2825379669,829329135,1181335161,3412177804,3160834842,628085408,1382605366,3423369109,3138078467,570562233,1426400815,3317316542,2998733608,733239954,1555261956,3268935591,3050360625,752459403,1541320221,2607071920,3965973030,1969922972,40735498,2617837225,3943577151,1913087877,83908371,2512341634,3803740692,2075208622,213261112,2463272603,3855990285,2094854071,198958881,2262029012,4057260610,1759359992,534414190,2176718541,4139329115,1873836001,414664567,2282248934,4279200368,1711684554,285281116,2405801727,4167216745,1634467795,376229701,2685067896,3608007406,1308918612,956543938,2808555105,3495958263,1231636301,1047427035,2932959818,3654703836,1088359270,936918e3,2847714899,3736837829,1202900863,817233897,3183342108,3401237130,1404277552,615818150,3134207493,3453421203,1423857449,601450431,3009837614,3294710456,1567103746,711928724,3020668471,3272380065,1510334235,755167117];typeof Int32Array<"u"&&(Ud=new Int32Array(Ud));const a9=(t,e)=>{let n=e===0?0:~~e^-1;for(let r=0;r<t.length;r++)n=Ud[(n^t[r])&255]^n>>>8;return n^-1},ex=(t,e)=>Ke.Buffer.from(t,e);function c9(t,e){const n=(r,o)=>e(ex(r),o)>>>0;return n.signed=(r,o)=>e(ex(r),o),n.unsigned=n,n.model=t,n}const l9=c9("crc-32",a9),u9=21582659,f9=38359875;function h9(t,e){return t*2**e}function tx(t,e){return Math.floor(t/2**e)}let Kl=class extends $w{constructor(){super(...arguments),this.maxBinNumber=0,this.depth=0,this.minShift=0}async lineCount(e,n){var r,o;return((o=(r=(await this.parse(n)).indices[e])===null||r===void 0?void 0:r.stats)===null||o===void 0?void 0:o.lineCount)||0}async indexCov(){return[]}parseAuxData(e,n){const r=e.readInt32LE(n),o=r&65536?"zero-based-half-open":"1-based-closed",i={0:"generic",1:"SAM",2:"VCF"}[r&15];if(!i)throw new Error(`invalid Tabix preset format flags ${r}`);const s={ref:e.readInt32LE(n+4),start:e.readInt32LE(n+8),end:e.readInt32LE(n+12)},a=e.readInt32LE(n+16),c=a?String.fromCharCode(a):"",l=e.readInt32LE(n+20),u=e.readInt32LE(n+24);return{columnNumbers:s,coordinateType:o,metaValue:a,metaChar:c,skipLines:l,format:i,formatFlags:r,...n9(e.subarray(n+28,n+28+u),this.renameRefSeq)}}async _parse(e){const n=await this.filehandle.readFile(e),r=await Or(n);let o;if(r.readUInt32LE(0)===u9)o=1;else if(r.readUInt32LE(0)===f9)o=2;else throw new Error("Not a CSI file");this.minShift=r.readInt32LE(4),this.depth=r.readInt32LE(8),this.maxBinNumber=((1<<(this.depth+1)*3)-1)/7;const i=r.readInt32LE(12),s=i>=30?this.parseAuxData(r,16):void 0,a=r.readInt32LE(16+i);let c=16+i+4,l;const u=new Array(a);for(let f=0;f<a;f++){const d=r.readInt32LE(c);c+=4;const h={};let p;for(let b=0;b<d;b++){const v=r.readUInt32LE(c);if(c+=4,v>this.maxBinNumber)p=Jw(r,c+28),c+=44;else{l=Xl(l,Co(r,c)),c+=8;const y=r.readInt32LE(c);c+=4;const A=new Array(y);for(let S=0;S<y;S+=1){const E=Co(r,c);c+=8;const I=Co(r,c);c+=8,l=Xl(l,E),A[S]=new zd(E,I,v)}h[v]=A}}u[f]={binIndex:h,stats:p}}return{csiVersion:o,firstDataLine:l,indices:u,refCount:a,csi:!0,maxBlockSize:65536,...s}}async blocksForRange(e,n,r,o={}){n<0&&(n=0);const s=(await this.parse(o)).indices[e];if(!s)return[];const a=this.reg2bins(n,r);if(a.length===0)return[];const c=[];for(const[l,u]of a)for(let f=l;f<=u;f++)if(s.binIndex[f]){const d=s.binIndex[f];for(const h of d)c.push(h)}return Kw(c,new Xw(0,0))}reg2bins(e,n){e-=1,e<1&&(e=1),n>2**50&&(n=2**34),n-=1;let r=0,o=0,i=this.minShift+this.depth*3;const s=[];for(;r<=this.depth;i-=3,o+=h9(1,r*3),r+=1){const a=o+tx(e,i),c=o+tx(n,i);if(c-a+s.length>this.maxBinNumber)throw new Error(`query ${e}-${n} is too large for current binning scheme (shift ${this.minShift}, depth ${this.depth}), try a smaller query or a coarser index binning scheme`);s.push([a,c])}return s}async parse(e={}){return this.setupP||(this.setupP=this._parse(e).catch(n=>{throw this.setupP=void 0,n})),this.setupP}async hasRefSeq(e,n={}){var r;return!!(!((r=(await this.parse(n)).indices[e])===null||r===void 0)&&r.binIndex)}};const gn={BAM_FPAIRED:1,BAM_FPROPER_PAIR:2,BAM_FUNMAP:4,BAM_FMUNMAP:8,BAM_FREVERSE:16,BAM_FMREVERSE:32,BAM_FREAD1:64,BAM_FREAD2:128,BAM_FSECONDARY:256,BAM_FQCFAIL:512,BAM_FDUP:1024,BAM_FSUPPLEMENTARY:2048},nx="=ACMGRSVTWYHKDBN".split(""),Ba="MIDNSHP=X???????".split("");class To{constructor(e){this.bytes=e.bytes,this.fileOffset=e.fileOffset}get byteArray(){return this.bytes.byteArray}get flags(){return(this.byteArray.readInt32LE(this.bytes.start+16)&4294901760)>>16}get ref_id(){return this.byteArray.readInt32LE(this.bytes.start+4)}get start(){return this.byteArray.readInt32LE(this.bytes.start+8)}get end(){return this.start+this.length_on_ref}get id(){return this.fileOffset}get mq(){const e=(this.bin_mq_nl&65280)>>8;return e===255?void 0:e}get score(){return this.mq}get qual(){if(this.isSegmentUnmapped())return;const e=this.b0+this.read_name_length+this.num_cigar_ops*4+this.num_seq_bytes;return this.byteArray.subarray(e,e+this.seq_length)}get strand(){return this.isReverseComplemented()?-1:1}get b0(){return this.bytes.start+36}get name(){return this.byteArray.toString("ascii",this.b0,this.b0+this.read_name_length-1)}get tags(){const{byteArray:e}=this.bytes;let n=this.b0+this.read_name_length+this.num_cigar_ops*4+this.num_seq_bytes+this.seq_length;const r=this.bytes.end,o={};for(;n<r;){const i=String.fromCharCode(e[n],e[n+1]),s=String.fromCharCode(e[n+2]);if(n+=3,s==="A")o[i]=String.fromCharCode(e[n]),n+=1;else if(s==="i")o[i]=e.readInt32LE(n),n+=4;else if(s==="I")o[i]=e.readUInt32LE(n),n+=4;else if(s==="c")o[i]=e.readInt8(n),n+=1;else if(s==="C")o[i]=e.readUInt8(n),n+=1;else if(s==="s")o[i]=e.readInt16LE(n),n+=2;else if(s==="S")o[i]=e.readUInt16LE(n),n+=2;else if(s==="f")o[i]=e.readFloatLE(n),n+=4;else if(s==="Z"||s==="H"){const a=[];for(;n<=r;){const c=e[n++];if(c!==0)a.push(String.fromCharCode(c));else break}o[i]=a.join("")}else if(s==="B"){const a=e[n++],c=String.fromCharCode(a),l=e.readInt32LE(n);if(n+=4,c==="i")if(i==="CG"){const u=[];for(let f=0;f<l;f++){const d=e.readInt32LE(n),h=d>>4,p=Ba[d&15];u.push(h+p),n+=4}o[i]=u.join("")}else{const u=[];for(let f=0;f<l;f++)u.push(e.readInt32LE(n)),n+=4;o[i]=u}else if(c==="I")if(i==="CG"){const u=[];for(let f=0;f<l;f++){const d=e.readUInt32LE(n),h=d>>4,p=Ba[d&15];u.push(h+p),n+=4}o[i]=u.join("")}else{const u=[];for(let f=0;f<l;f++)u.push(e.readUInt32LE(n)),n+=4;o[i]=u}else if(c==="s"){const u=[];for(let f=0;f<l;f++)u.push(e.readInt16LE(n)),n+=2;o[i]=u}else if(c==="S"){const u=[];for(let f=0;f<l;f++)u.push(e.readUInt16LE(n)),n+=2;o[i]=u}else if(c==="c"){const u=[];for(let f=0;f<l;f++)u.push(e.readInt8(n)),n+=1;o[i]=u}else if(c==="C"){const u=[];for(let f=0;f<l;f++)u.push(e.readUInt8(n)),n+=1;o[i]=u}else if(c==="f"){const u=[];for(let f=0;f<l;f++)u.push(e.readFloatLE(n)),n+=4;o[i]=u}}else{console.error("Unknown BAM tag type",s);break}}return o}isPaired(){return!!(this.flags&gn.BAM_FPAIRED)}isProperlyPaired(){return!!(this.flags&gn.BAM_FPROPER_PAIR)}isSegmentUnmapped(){return!!(this.flags&gn.BAM_FUNMAP)}isMateUnmapped(){return!!(this.flags&gn.BAM_FMUNMAP)}isReverseComplemented(){return!!(this.flags&gn.BAM_FREVERSE)}isMateReverseComplemented(){return!!(this.flags&gn.BAM_FMREVERSE)}isRead1(){return!!(this.flags&gn.BAM_FREAD1)}isRead2(){return!!(this.flags&gn.BAM_FREAD2)}isSecondary(){return!!(this.flags&gn.BAM_FSECONDARY)}isFailedQc(){return!!(this.flags&gn.BAM_FQCFAIL)}isDuplicate(){return!!(this.flags&gn.BAM_FDUP)}isSupplementary(){return!!(this.flags&gn.BAM_FSUPPLEMENTARY)}get cigarAndLength(){if(this.isSegmentUnmapped())return{length_on_ref:0,CIGAR:""};const e=this.num_cigar_ops;let n=this.b0+this.read_name_length;const r=[];let o=this.byteArray.readInt32LE(n),i=o>>4,s=Ba[o&15];if(s==="S"&&i===this.seq_length)return n+=4,o=this.byteArray.readInt32LE(n),i=o>>4,s=Ba[o&15],s!=="N"&&console.warn("CG tag with no N tag"),{CIGAR:this.tags.CG,length_on_ref:i};{let a=0;for(let c=0;c<e;++c)o=this.byteArray.readInt32LE(n),i=o>>4,s=Ba[o&15],r.push(i+s),s!=="H"&&s!=="S"&&s!=="I"&&(a+=i),n+=4;return{CIGAR:r.join(""),length_on_ref:a}}}get length_on_ref(){return this.cigarAndLength.length_on_ref}get CIGAR(){return this.cigarAndLength.CIGAR}get num_cigar_ops(){return this.flag_nc&65535}get read_name_length(){return this.bin_mq_nl&255}get num_seq_bytes(){return this.seq_length+1>>1}get seq(){const{byteArray:e}=this.bytes,n=this.b0+this.read_name_length+this.num_cigar_ops*4,r=this.num_seq_bytes,o=this.seq_length,i=[];let s=0;for(let a=0;a<r;++a){const c=e[n+a];i.push(nx[(c&240)>>4]),s++,s<o&&(i.push(nx[c&15]),s++)}return i.join("")}get pair_orientation(){if(!this.isSegmentUnmapped()&&!this.isMateUnmapped()&&this.ref_id===this.next_refid){const e=this.isReverseComplemented()?"R":"F",n=this.isMateReverseComplemented()?"R":"F";let r=" ",o=" ";this.isRead1()?(r="1",o="2"):this.isRead2()&&(r="2",o="1");const i=[];return this.template_length>0?(i[0]=e,i[1]=r,i[2]=n,i[3]=o):(i[2]=e,i[3]=r,i[0]=n,i[1]=o),i.join("")}}get bin_mq_nl(){return this.byteArray.readInt32LE(this.bytes.start+12)}get flag_nc(){return this.byteArray.readInt32LE(this.bytes.start+16)}get seq_length(){return this.byteArray.readInt32LE(this.bytes.start+20)}get next_refid(){return this.byteArray.readInt32LE(this.bytes.start+24)}get next_pos(){return this.byteArray.readInt32LE(this.bytes.start+28)}get template_length(){return this.byteArray.readInt32LE(this.bytes.start+32)}toJSON(){const e={};for(const n of Object.keys(this))n.startsWith("_")||n==="bytes"||(e[n]=this[n]);return e}}function Jl(t,e){const n=Object.getOwnPropertyDescriptor(t.prototype,e);if(!n)throw new Error("OH NO, NO PROPERTY DESCRIPTOR");const r=n.get;if(!r)throw new Error("OH NO, NOT A GETTER");Object.defineProperty(t.prototype,e,{get(){const o=r.call(this);return Object.defineProperty(this,e,{value:o}),o}})}Jl(To,"tags"),Jl(To,"cigarAndLength"),Jl(To,"seq"),Jl(To,"qual");function rx(t){const e=t.split(/\r?\n/),n=[];for(const r of e){const[o,...i]=r.split(/\t/);o&&n.push({tag:o.slice(1),data:i.map(s=>{const a=s.indexOf(":"),c=s.slice(0,a),l=s.slice(a+1);return{tag:c,value:l}})})}return n}const ix=21840194,ox=65536;async function d9(t){let e=[];for await(const n of t)e=e.concat(n);return e}class p9{read(){throw new Error("never called")}stat(){throw new Error("never called")}readFile(){throw new Error("never called")}close(){throw new Error("never called")}}class sx{constructor({bamFilehandle:e,bamPath:n,bamUrl:r,baiPath:o,baiFilehandle:i,baiUrl:s,csiPath:a,csiFilehandle:c,csiUrl:l,htsget:u,yieldThreadTime:f=100,renameRefSeqs:d=h=>h}){if(this.htsget=!1,this.featureCache=new Ei({cache:new zl({maxSize:50}),fill:async(h,p)=>{const{chunk:b,opts:v}=h,{data:y,cpositions:A,dpositions:S}=await this._readChunk({chunk:b,opts:{...v,signal:p}});return this.readBamFeatures(y,A,S,b)}}),this.renameRefSeq=d,e)this.bam=e;else if(n)this.bam=new Ct(n);else if(r)this.bam=new Cn(r);else if(u)this.htsget=!0,this.bam=new p9;else throw new Error("unable to initialize bam");if(c)this.index=new Kl({filehandle:c});else if(a)this.index=new Kl({filehandle:new Ct(a)});else if(l)this.index=new Kl({filehandle:new Cn(l)});else if(i)this.index=new Io({filehandle:i});else if(o)this.index=new Io({filehandle:new Ct(o)});else if(s)this.index=new Io({filehandle:new Cn(s)});else if(n)this.index=new Io({filehandle:new Ct(`${n}.bai`)});else if(r)this.index=new Io({filehandle:new Cn(`${r}.bai`)});else if(u)this.htsget=!0;else throw new Error("unable to infer index format");this.yieldThreadTime=f}async getHeaderPre(e){const n=t9(e);if(!this.index)return;const r=await this.index.parse(n),o=r.firstDataLine?r.firstDataLine.blockPosition+65535:void 0;let i;if(o){const u=o+ox,f=await this.bam.read(Ke.Buffer.alloc(u),0,u,0,n);if(!f.bytesRead)throw new Error("Error reading header");i=f.buffer.subarray(0,Math.min(f.bytesRead,o))}else i=await this.bam.readFile(n);const s=await Or(i);if(s.readInt32LE(0)!==ix)throw new Error("Not a BAM file");const a=s.readInt32LE(4);this.header=s.toString("utf8",8,8+a);const{chrToIndex:c,indexToChr:l}=await this._readRefSeqs(a+8,65535,n);return this.chrToIndex=c,this.indexToChr=l,rx(this.header)}getHeader(e){return this.headerP||(this.headerP=this.getHeaderPre(e).catch(n=>{throw this.headerP=void 0,n})),this.headerP}async getHeaderText(e={}){return await this.getHeader(e),this.header}async _readRefSeqs(e,n,r){if(e>n)return this._readRefSeqs(e,n*2,r);const o=n+ox,{bytesRead:i,buffer:s}=await this.bam.read(Ke.Buffer.alloc(o),0,n,0,r);if(!i)throw new Error("Error reading refseqs from header");const a=await Or(s.subarray(0,Math.min(i,n))),c=a.readInt32LE(e);let l=e+4;const u={},f=[];for(let d=0;d<c;d+=1){const h=a.readInt32LE(l),p=this.renameRefSeq(a.toString("utf8",l+4,l+4+h-1)),b=a.readInt32LE(l+h+4);if(u[p]=d,f.push({refName:p,length:b}),l=l+8+h,l>a.length)return console.warn(`BAM header is very big. Re-fetching ${n} bytes.`),this._readRefSeqs(e,n*2,r)}return{chrToIndex:u,indexToChr:f}}async getRecordsForRange(e,n,r,o){return d9(this.streamRecordsForRange(e,n,r,o))}async*streamRecordsForRange(e,n,r,o){var i;await this.getHeader(o);const s=(i=this.chrToIndex)===null||i===void 0?void 0:i[e];if(s===void 0||!this.index)yield[];else{const a=await this.index.blocksForRange(s,n-1,r,o);yield*this._fetchChunkFeatures(a,s,n,r,o)}}async*_fetchChunkFeatures(e,n,r,o,i={}){const{viewAsPairs:s}=i,a=[];let c=!1;for(const l of e){const u=await this.featureCache.get(l.toString(),{chunk:l,opts:i},i.signal),f=[];for(const d of u)if(d.ref_id===n)if(d.start>=o){c=!0;break}else d.end>=r&&f.push(d);if(a.push(f),yield f,c)break}$F(i.signal),s&&(yield this.fetchPairs(n,a,i))}async fetchPairs(e,n,r){const{pairAcrossChr:o,maxInsertSize:i=2e5}=r,s={},a={};n.map(d=>{const h={};for(const p of d){const b=p.name,v=p.id;h[b]||(h[b]=0),h[b]++,a[v]=1}for(const[p,b]of Object.entries(h))b===1&&(s[p]=!0)});const c=[];n.map(d=>{for(const h of d){const p=h.name,b=h.start,v=h.next_pos,y=h.next_refid;this.index&&s[p]&&(o||y===e&&Math.abs(b-v)<i)&&c.push(this.index.blocksForRange(y,v,v+1,r))}});const l=new Map,u=await Promise.all(c);for(const d of u.flat())l.has(d.toString())||l.set(d.toString(),d);return(await Promise.all([...l.values()].map(async d=>{const{data:h,cpositions:p,dpositions:b,chunk:v}=await this._readChunk({chunk:d,opts:r}),y=[];for(const A of await this.readBamFeatures(h,p,b,v))s[A.name]&&!a[A.id]&&y.push(A);return y}))).flat()}async _readRegion(e,n,r={}){const{bytesRead:o,buffer:i}=await this.bam.read(Ke.Buffer.alloc(n),0,n,e,r);return i.subarray(0,Math.min(o,n))}async _readChunk({chunk:e,opts:n}){const r=await this._readRegion(e.minv.blockPosition,e.fetchedSize(),n),{buffer:o,cpositions:i,dpositions:s}=await m2(r,e);return{data:o,cpositions:i,dpositions:s,chunk:e}}async readBamFeatures(e,n,r,o){let i=0;const s=[];let a=0,c=+Date.now();for(;i+4<e.length;){const l=e.readInt32LE(i),u=i+4+l-1;if(r){for(;i+o.minv.dataPosition>=r[a++];);a--}if(u<e.length){const f=new To({bytes:{byteArray:e,start:i,end:u},fileOffset:n.length>0?n[a]*256+(i-r[a])+o.minv.dataPosition+1:l9.signed(e.slice(i,u))});s.push(f),this.yieldThreadTime&&+Date.now()-c>this.yieldThreadTime&&(await JF(1),c=+Date.now())}i=u+1}return s}async hasRefSeq(e){var n,r;const o=(n=this.chrToIndex)===null||n===void 0?void 0:n[e];return o===void 0?!1:(r=this.index)===null||r===void 0?void 0:r.hasRefSeq(o)}async lineCount(e){var n;const r=(n=this.chrToIndex)===null||n===void 0?void 0:n[e];return r===void 0||!this.index?0:this.index.lineCount(r)}async indexCov(e,n,r){var o;if(!this.index)return[];await this.index.parse();const i=(o=this.chrToIndex)===null||o===void 0?void 0:o[e];return i===void 0?[]:this.index.indexCov(i,n,r)}async blocksForRange(e,n,r,o){var i;if(!this.index)return[];await this.index.parse();const s=(i=this.chrToIndex)===null||i===void 0?void 0:i[e];return s===void 0?[]:this.index.blocksForRange(s,n,r,o)}}async function ax(t,e){const n=await Promise.all(t.map(async r=>{const{url:o,headers:i}=r;if(o.startsWith("data:"))return Ke.Buffer.from(o.split(",")[1],"base64");{const{referer:s,...a}=i,c=await fetch(o,{...e,headers:{...e==null?void 0:e.headers,...a}});if(!c.ok)throw new Error(`HTTP ${c.status} fetching ${o}: ${await c.text()}`);return Ke.Buffer.from(await c.arrayBuffer())}}));return Ke.Buffer.concat(await Promise.all(n.map(r=>Or(r))))}class g9 extends sx{constructor(e){super({htsget:!0}),this.baseUrl=e.baseUrl,this.trackId=e.trackId}async*streamRecordsForRange(e,n,r,o){var i;const a=`${`${this.baseUrl}/${this.trackId}`}?referenceName=${e}&start=${n}&end=${r}&format=BAM`,c=(i=this.chrToIndex)===null||i===void 0?void 0:i[e];if(c===void 0)yield[];else{const l=await fetch(a,{...o});if(!l.ok)throw new Error(`HTTP ${l.status} fetching ${a}: ${await l.text()}`);const u=await l.json(),f=await ax(u.htsget.urls.slice(1),o);yield*this._fetchChunkFeatures([{buffer:f,_fetchedSize:void 0,bin:0,compareTo(){return 0},toUniqueString(){return`${e}_${n}_${r}`},fetchedSize(){return 0},minv:{dataPosition:0,blockPosition:0,compareTo:()=>0},maxv:{dataPosition:Number.MAX_SAFE_INTEGER,blockPosition:0,compareTo:()=>0},toString(){return`${e}_${n}_${r}`}}],c,n,r,o)}}async _readChunk({chunk:e}){if(!e.buffer)throw new Error("expected chunk.buffer in htsget");return{data:e.buffer,cpositions:[],dpositions:[],chunk:e}}async getHeader(e={}){const n=`${this.baseUrl}/${this.trackId}?referenceName=na&class=header`,r=await fetch(n,e);if(!r.ok)throw new Error(`HTTP ${r.status} fetching ${n}: ${await r.text()}`);const o=await r.json(),i=await ax(o.htsget.urls,e);if(i.readInt32LE(0)!==ix)throw new Error("Not a BAM file");const s=i.readInt32LE(4),a=i.toString("utf8",8,8+s),c=rx(a),l=[],u={},f=c.filter(d=>d.tag==="SQ");for(const[d,h]of f.entries()){let p="",b=0;for(const v of h.data)v.tag==="SN"?p=v.value:v.tag==="LN"&&(b=+v.value);u[p]=d,l[d]={refName:p,length:b}}return this.chrToIndex=u,this.indexToChr=l,c}}const m9=Object.freeze(Object.defineProperty({__proto__:null,BAI:Io,BamFile:sx,BamRecord:To,CSI:Kl,HtsgetFile:g9},Symbol.toStringTag,{value:"Module"}));function cx(t){if(t.greaterThan(Number.MAX_SAFE_INTEGER)||t.lessThan(Number.MIN_SAFE_INTEGER))throw new Error("integer overflow");return t.toNumber()}class b9 extends Error{}function ka(t){if(t&&t.aborted){if(typeof DOMException<"u")throw new DOMException("aborted","AbortError");{const e=new b9("aborted");throw e.code="ERR_ABORTED",e}}}function y9(t,e){return e.minv.blockPosition-t.maxv.blockPosition<65e3&&e.maxv.blockPosition-t.minv.blockPosition<5e6}function lx(t,e){const n=[];let r=null;return t.length===0?t:(t.sort(function(o,i){const s=o.minv.blockPosition-i.minv.blockPosition;return s!==0?s:o.minv.dataPosition-i.minv.dataPosition}),t.forEach(o=>{(!e||o.maxv.compareTo(e)>0)&&(r===null?(n.push(o),r=o):y9(r,o)?o.maxv.compareTo(r.maxv)>0&&(r.maxv=o.maxv):(n.push(o),r=o))}),n)}class Gd{constructor(e,n){this.blockPosition=e,this.dataPosition=n}toString(){return`${this.blockPosition}:${this.dataPosition}`}compareTo(e){return this.blockPosition-e.blockPosition||this.dataPosition-e.dataPosition}}function Do(t,e=0,n=!1){if(n)throw new Error("big-endian virtual file offsets not implemented");return new Gd(t[e+7]*1099511627776+t[e+6]*4294967296+t[e+5]*16777216+t[e+4]*65536+t[e+3]*256+t[e+2],t[e+1]<<8|t[e])}class $l{constructor(e,n,r,o=void 0){this.minv=e,this.maxv=n,this.bin=r,this._fetchedSize=o}toUniqueString(){return`${this.minv}..${this.maxv} (bin ${this.bin}, fetchedSize ${this.fetchedSize()})`}toString(){return this.toUniqueString()}compareTo(e){return this.minv.compareTo(e.minv)||this.maxv.compareTo(e.maxv)||this.bin-e.bin}fetchedSize(){return this._fetchedSize!==void 0?this._fetchedSize:this.maxv.blockPosition+65536-this.minv.blockPosition}}class ux{constructor({filehandle:e,renameRefSeqs:n=r=>r}){this.filehandle=e,this.renameRefSeq=n}async getMetadata(e={}){const{indices:n,...r}=await this.parse(e);return r}_findFirstData(e,n){return e?e.compareTo(n)>0?n:e:n}async parse(e={}){return this.parseP||(this.parseP=this._parse(e).catch(n=>{throw this.parseP=void 0,n})),this.parseP}async hasRefSeq(e,n={}){var r;return!!(!((r=(await this.parse(n)).indices[e])===null||r===void 0)&&r.binIndex)}}const w9=21578324,fx=14;function x9(t,e){return t+=1,e-=1,[[0,0],[1+(t>>26),1+(e>>26)],[9+(t>>23),9+(e>>23)],[73+(t>>20),73+(e>>20)],[585+(t>>17),585+(e>>17)],[4681+(t>>14),4681+(e>>14)]]}class Bo extends ux{async lineCount(e,n={}){const r=await this.parse(n),o=r.refNameToId[e];if(o===void 0||!r.indices[o])return-1;const{stats:s}=r.indices[o];return s?s.lineCount:-1}async _parse(e={}){const n=await this.filehandle.readFile(e),r=await Or(n);if(ka(e.signal),r.readUInt32LE(0)!==w9)throw new Error("Not a TBI file");const o=r.readInt32LE(4),i=r.readInt32LE(8),s=i&65536?"zero-based-half-open":"1-based-closed",c={0:"generic",1:"SAM",2:"VCF"}[i&15];if(!c)throw new Error(`invalid Tabix preset format flags ${i}`);const l={ref:r.readInt32LE(12),start:r.readInt32LE(16),end:r.readInt32LE(20)},u=r.readInt32LE(24),f=5,d=((1<<(f+1)*3)-1)/7,h=2**(14+f*3),p=u?String.fromCharCode(u):null,b=r.readInt32LE(28),v=r.readInt32LE(32),{refNameToId:y,refIdToName:A}=this._parseNameBytes(r.slice(36,36+v));let S=36+v,E;return{indices:new Array(o).fill(0).map(()=>{const _=r.readInt32LE(S);S+=4;const B={};let N;for(let C=0;C<_;C+=1){const Y=r.readUInt32LE(S);if(S+=4,Y>d+1)throw new Error("tabix index contains too many bins, please use a CSI index");if(Y===d+1){const Q=r.readInt32LE(S);S+=4,Q===2&&(N=this.parsePseudoBin(r,S)),S+=16*Q}else{const Q=r.readInt32LE(S);S+=4;const se=new Array(Q);for(let oe=0;oe<Q;oe+=1){const ae=Do(r,S),ce=Do(r,S+8);S+=16,E=this._findFirstData(E,ae),se[oe]=new $l(ae,ce,Y)}B[Y]=se}}const F=r.readInt32LE(S);S+=4;const M=new Array(F);for(let C=0;C<F;C+=1)M[C]=Do(r,S),S+=8,E=this._findFirstData(E,M[C]);return{binIndex:B,linearIndex:M,stats:N}}),metaChar:p,maxBinNumber:d,maxRefLength:h,skipLines:b,firstDataLine:E,columnNumbers:l,coordinateType:s,format:c,refIdToName:A,refNameToId:y,maxBlockSize:65536}}parsePseudoBin(e,n){return{lineCount:cx(Ol.fromBytesLE(e.slice(n+16,n+24),!0))}}_parseNameBytes(e){let n=0,r=0;const o=[],i={};for(let s=0;s<e.length;s+=1)if(!e[s]){if(r<s){let a=e.toString("utf8",r,s);a=this.renameRefSeq(a),o[n]=a,i[a]=n}r=s+1,n+=1}return{refNameToId:i,refIdToName:o}}async blocksForRange(e,n,r,o={}){n<0&&(n=0);const i=await this.parse(o),s=i.refNameToId[e];if(s===void 0)return[];const a=i.indices[s];if(!a)return[];(a.linearIndex.length?a.linearIndex[n>>fx>=a.linearIndex.length?a.linearIndex.length-1:n>>fx]:new Gd(0,0))||console.warn("querying outside of possible tabix range");const l=x9(n,r),u=[];for(const[b,v]of l)for(let y=b;y<=v;y++)if(a.binIndex[y])for(const A of a.binIndex[y])u.push(new $l(A.minv,A.maxv,y));const f=a.linearIndex.length;let d=null;const h=Math.min(n>>14,f-1),p=Math.min(r>>14,f-1);for(let b=h;b<=p;++b){const v=a.linearIndex[b];v&&(!d||v.compareTo(d)<0)&&(d=v)}return lx(u,d)}}const v9=21582659,A9=38359875;function E9(t,e){return t*2**e}function hx(t,e){return Math.floor(t/2**e)}class eu extends ux{constructor(e){super(e),this.maxBinNumber=0,this.depth=0,this.minShift=0}async lineCount(e,n={}){const r=await this.parse(n),o=r.refNameToId[e];if(o===void 0||!r.indices[o])return-1;const{stats:s}=r.indices[o];return s?s.lineCount:-1}indexCov(){throw new Error("CSI indexes do not support indexcov")}parseAuxData(e,n){const r=e.readInt32LE(n),o=r&65536?"zero-based-half-open":"1-based-closed",i={0:"generic",1:"SAM",2:"VCF"}[r&15];if(!i)throw new Error(`invalid Tabix preset format flags ${r}`);const s={ref:e.readInt32LE(n+4),start:e.readInt32LE(n+8),end:e.readInt32LE(n+12)},a=e.readInt32LE(n+16),c=a?String.fromCharCode(a):null,l=e.readInt32LE(n+20),u=e.readInt32LE(n+24),{refIdToName:f,refNameToId:d}=this._parseNameBytes(e.slice(n+28,n+28+u));return{refIdToName:f,refNameToId:d,skipLines:l,metaChar:c,columnNumbers:s,format:i,coordinateType:o}}_parseNameBytes(e){let n=0,r=0;const o=[],i={};for(let s=0;s<e.length;s+=1)if(!e[s]){if(r<s){let a=e.toString("utf8",r,s);a=this.renameRefSeq(a),o[n]=a,i[a]=n}r=s+1,n+=1}return{refNameToId:i,refIdToName:o}}async _parse(e={}){const n=await Or(await this.filehandle.readFile(e));let r;if(n.readUInt32LE(0)===v9)r=1;else if(n.readUInt32LE(0)===A9)r=2;else throw new Error("Not a CSI file");this.minShift=n.readInt32LE(4),this.depth=n.readInt32LE(8),this.maxBinNumber=((1<<(this.depth+1)*3)-1)/7;const o=2**(this.minShift+this.depth*3),i=n.readInt32LE(12),s=i&&i>=30?this.parseAuxData(n,16):{refIdToName:[],refNameToId:{},metaChar:null,columnNumbers:{ref:0,start:1,end:2},coordinateType:"zero-based-half-open",format:"generic"},a=n.readInt32LE(16+i);let c,l=16+i+4;const u=new Array(a).fill(0).map(()=>{const f=n.readInt32LE(l);l+=4;const d={};let h;for(let p=0;p<f;p+=1){const b=n.readUInt32LE(l);if(b>this.maxBinNumber)h=this.parsePseudoBin(n,l+4),l+=48;else{const v=Do(n,l+4);c=this._findFirstData(c,v);const y=n.readInt32LE(l+12);l+=16;const A=new Array(y);for(let S=0;S<y;S+=1){const E=Do(n,l),I=Do(n,l+8);l+=16,A[S]=new $l(E,I,b)}d[b]=A}}return{binIndex:d,stats:h}});return{...s,csi:!0,refCount:a,maxBlockSize:65536,firstDataLine:c,csiVersion:r,indices:u,depth:this.depth,maxBinNumber:this.maxBinNumber,maxRefLength:o}}parsePseudoBin(e,n){return{lineCount:cx(Ol.fromBytesLE(e.slice(n+28,n+36),!0))}}async blocksForRange(e,n,r,o={}){n<0&&(n=0);const i=await this.parse(o),s=i.refNameToId[e];if(s===void 0)return[];const a=i.indices[s];if(!a)return[];const c=this.reg2bins(n,r),l=[];for(const[u,f]of c)for(let d=u;d<=f;d++)if(a.binIndex[d])for(const h of a.binIndex[d])l.push(new $l(h.minv,h.maxv,d));return lx(l,new Gd(0,0))}reg2bins(e,n){e-=1,e<1&&(e=1),n>2**50&&(n=2**34),n-=1;let r=0,o=0,i=this.minShift+this.depth*3;const s=[];for(;r<=this.depth;i-=3,o+=E9(1,r*3),r+=1){const a=o+hx(e,i),c=o+hx(n,i);if(c-a+s.length>this.maxBinNumber)throw new Error(`query ${e}-${n} is too large for current binning scheme (shift ${this.minShift}, depth ${this.depth}), try a smaller query or a coarser index binning scheme`);s.push([a,c])}return s}}function S9(t){return/^[\u0000-\u007F]*$/.test(t)}const ko=typeof TextDecoder<"u"?new TextDecoder("utf8"):void 0;class C9{constructor({path:e,filehandle:n,url:r,tbiPath:o,tbiUrl:i,tbiFilehandle:s,csiPath:a,csiUrl:c,csiFilehandle:l,renameRefSeqs:u=d=>d,chunkCacheSize:f=5*2**20}){if(n)this.filehandle=n;else if(e)this.filehandle=new Ct(e);else if(r)this.filehandle=new Cn(r);else throw new TypeError("must provide either filehandle or path");if(s)this.index=new Bo({filehandle:s,renameRefSeqs:u});else if(l)this.index=new eu({filehandle:l,renameRefSeqs:u});else if(o)this.index=new Bo({filehandle:new Ct(o),renameRefSeqs:u});else if(a)this.index=new eu({filehandle:new Ct(a),renameRefSeqs:u});else if(e)this.index=new Bo({filehandle:new Ct(`${e}.tbi`),renameRefSeqs:u});else if(c)this.index=new eu({filehandle:new Cn(c)});else if(i)this.index=new Bo({filehandle:new Cn(i)});else if(r)this.index=new Bo({filehandle:new Cn(`${r}.tbi`)});else throw new TypeError("must provide one of tbiFilehandle, tbiPath, csiFilehandle, csiPath, tbiUrl, csiUrl");this.renameRefSeq=u,this.chunkCache=new Ei({cache:new zl({maxSize:Math.floor(f/65536)}),fill:(d,h)=>this.readChunk(d,{signal:h})})}async getLines(e,n,r,o){var i,s;let a,c={},l;typeof o=="function"?l=o:(c=o,l=o.lineCallback,a=o.signal);const u=await this.index.getMetadata(c);ka(a);const f=n??0,d=r??u.maxRefLength;if(!(f<=d))throw new TypeError("invalid start and end coordinates. start must be less than or equal to end");if(f===d)return;const h=await this.index.blocksForRange(e,f,d,c);ka(a);for(const p of h){const{buffer:b,cpositions:v,dpositions:y}=await this.chunkCache.get(p.toString(),p,a);ka(a);let A=0,S=0;const E=(i=ko==null?void 0:ko.decode(b))!==null&&i!==void 0?i:b.toString(),I=b.length<5e8&&S9(E);for(;A<E.length;){let _,B;if(I){if(B=E.indexOf(`
|
|
815
815
|
`,A),B===-1)break;_=E.slice(A,B)}else{if(B=b.indexOf(`
|
|
816
|
-
`,A),B===-1)break;const F=b.slice(A,B);_=(s=ko==null?void 0:ko.decode(F))!==null&&s!==void 0?s:F.toString()}if(y){for(;A+p.minv.dataPosition>=y[S++];);S--}const{startCoordinate:N,overlaps:M}=this.checkLine(u,e,f,d,_);if(M)l(_,v[S]*256+(A-y[S])+p.minv.dataPosition+1);else if(N!==void 0&&N>=d)return;A=B+1}}}async getMetadata(e={}){return this.index.getMetadata(e)}async getHeaderBuffer(e={}){const{firstDataLine:n,metaChar:r,maxBlockSize:o}=await this.getMetadata(e);ka(e.signal);const i=((n==null?void 0:n.blockPosition)||0)+o,s=await this._readRegion(0,i,e),a=await Or(s);if(r){let c=-1;const l=10,u=r.charCodeAt(0);for(let f=0;f<a.length&&!(f===c+1&&a[f]!==u);f+=1)a[f]===l&&(c=f);return a.subarray(0,c+1)}return a}async getHeader(e={}){return(await this.getHeaderBuffer(e)).toString("utf8")}async getReferenceSequenceNames(e={}){return(await this.getMetadata(e)).refIdToName}checkLine(e,n,r,o,i){const{columnNumbers:s,metaChar:a,coordinateType:c,format:l}=e;if(a&&i.startsWith(a))return{overlaps:!1};let{ref:u,start:f,end:d}=s;u||(u=0),f||(f=0),d||(d=0),l==="VCF"&&(d=8);const h=Math.max(u,f,d);let p=1,b=0,v="",y=-1/0;const A=i.length;for(let S=0;S<A+1;S++)if(i[S]===" "||S===A){if(p===u){if(this.renameRefSeq(i.slice(b,S))!==n)return{overlaps:!1}}else if(p===f){if(y=parseInt(i.slice(b,S),10),c==="1-based-closed"&&(y-=1),y>=o)return{startCoordinate:y,overlaps:!1};if((d===0||d===f)&&y+1<=r)return{startCoordinate:y,overlaps:!1}}else if(l==="VCF"&&p===4)v=i.slice(b,S);else if(p===d&&(l==="VCF"?this._getVcfEnd(y,v,i.slice(b,S)):Number.parseInt(i.slice(b,S),10))<=r)return{overlaps:!1};if(b=S+1,p+=1,p>h)break}return{startCoordinate:y,overlaps:!0}}_getVcfEnd(e,n,r){let o=e+n.length;const i=r.includes("SVTYPE=TRA");if(r[0]!=="."&&!i){let s=";";for(let a=0;a<r.length;a+=1){if(s===";"&&r.slice(a,a+4)==="END="){let c=r.indexOf(";",a);c===-1&&(c=r.length),o=parseInt(r.slice(a+4,c),10);break}s=r[a]}}else if(i)return e+1;return o}async lineCount(e,n={}){return this.index.lineCount(e,n)}async _readRegion(e,n,r={}){const o=Ke.Buffer.alloc(n),{bytesRead:i,buffer:s}=await this.filehandle.read(o,0,n,e,r);return s.subarray(0,i)}async readChunk(e,n={}){const r=await this._readRegion(e.minv.blockPosition,e.fetchedSize(),n);return m2(r,e)}}const I9=Object.freeze(Object.defineProperty({__proto__:null,CSI:eu,TBI:Bo,TabixIndexedFile:C9},Symbol.toStringTag,{value:"Module"}));var tu={exports:{}},dx;function Hd(){if(dx)return tu.exports;dx=1;var t=typeof Reflect=="object"?Reflect:null,e=t&&typeof t.apply=="function"?t.apply:function(I,_,B){return Function.prototype.apply.call(I,_,B)},n;t&&typeof t.ownKeys=="function"?n=t.ownKeys:Object.getOwnPropertySymbols?n=function(I){return Object.getOwnPropertyNames(I).concat(Object.getOwnPropertySymbols(I))}:n=function(I){return Object.getOwnPropertyNames(I)};function r(E){console&&console.warn&&console.warn(E)}var o=Number.isNaN||function(I){return I!==I};function i(){i.init.call(this)}tu.exports=i,tu.exports.once=y,i.EventEmitter=i,i.prototype._events=void 0,i.prototype._eventsCount=0,i.prototype._maxListeners=void 0;var s=10;function a(E){if(typeof E!="function")throw new TypeError('The "listener" argument must be of type Function. 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zt(){c("unpipe"),te.unpipe(L)}return L.emit("pipe",te),le.flowing||(c("pipe resume"),te.resume()),L};function we(L){return function(){var te=L._readableState;c("pipeOnDrain",te.awaitDrain),te.awaitDrain&&te.awaitDrain--,te.awaitDrain===0&&e(L,"data")&&(te.flowing=!0,q(L))}}F.prototype.unpipe=function(L){var D=this._readableState,te={hasUnpiped:!1};if(D.pipesCount===0)return this;if(D.pipesCount===1)return L&&L!==D.pipes?this:(L||(L=D.pipes),D.pipes=null,D.pipesCount=0,D.flowing=!1,L&&L.emit("unpipe",this,te),this);if(!L){var le=D.pipes,Be=D.pipesCount;D.pipes=null,D.pipesCount=0,D.flowing=!1;for(var ve=0;ve<Be;ve++)le[ve].emit("unpipe",this,{hasUnpiped:!1});return this}var Ae=fe(D.pipes,L);return Ae===-1?this:(D.pipes.splice(Ae,1),D.pipesCount-=1,D.pipesCount===1&&(D.pipes=D.pipes[0]),L.emit("unpipe",this,te),this)},F.prototype.on=function(L,D){var te=n.prototype.on.call(this,L,D),le=this._readableState;return L==="data"?(le.readableListening=this.listenerCount("readable")>0,le.flowing!==!1&&this.resume()):L==="readable"&&!le.endEmitted&&!le.readableListening&&(le.readableListening=le.needReadable=!0,le.flowing=!1,le.emittedReadable=!1,c("on readable",le.length,le.reading),le.length?ce(this):le.reading||process.nextTick(Ie,this)),te},F.prototype.addListener=F.prototype.on,F.prototype.removeListener=function(L,D){var te=n.prototype.removeListener.call(this,L,D);return L==="readable"&&process.nextTick(Ee,this),te},F.prototype.removeAllListeners=function(L){var D=n.prototype.removeAllListeners.apply(this,arguments);return(L==="readable"||L===void 0)&&process.nextTick(Ee,this),D};function Ee(L){var D=L._readableState;D.readableListening=L.listenerCount("readable")>0,D.resumeScheduled&&!D.paused?D.flowing=!0:L.listenerCount("data")>0&&L.resume()}function Ie(L){c("readable nexttick read 0"),L.read(0)}F.prototype.resume=function(){var L=this._readableState;return L.flowing||(c("resume"),L.flowing=!L.readableListening,Ge(this,L)),L.paused=!1,this};function Ge(L,D){D.resumeScheduled||(D.resumeScheduled=!0,process.nextTick(Ve,L,D))}function Ve(L,D){c("resume",D.reading),D.reading||L.read(0),D.resumeScheduled=!1,L.emit("resume"),q(L),D.flowing&&!D.reading&&L.read(0)}F.prototype.pause=function(){return c("call pause flowing=%j",this._readableState.flowing),this._readableState.flowing!==!1&&(c("pause"),this._readableState.flowing=!1,this.emit("pause")),this._readableState.paused=!0,this};function q(L){var D=L._readableState;for(c("flow",D.flowing);D.flowing&&L.read()!==null;);}F.prototype.wrap=function(L){var D=this,te=this._readableState,le=!1;L.on("end",function(){if(c("wrapped end"),te.decoder&&!te.ended){var Ae=te.decoder.end();Ae&&Ae.length&&D.push(Ae)}D.push(null)}),L.on("data",function(Ae){if(c("wrapped data"),te.decoder&&(Ae=te.decoder.write(Ae)),!(te.objectMode&&Ae==null)&&!(!te.objectMode&&(!Ae||!Ae.length))){var 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this._readableState.flowing},set:function(D){this._readableState&&(this._readableState.flowing=D)}}),F._fromList=j,Object.defineProperty(F.prototype,"readableLength",{enumerable:!1,get:function(){return this._readableState.length}});function j(L,D){if(D.length===0)return null;var te;return D.objectMode?te=D.buffer.shift():!L||L>=D.length?(D.decoder?te=D.buffer.join(""):D.buffer.length===1?te=D.buffer.first():te=D.buffer.concat(D.length),D.buffer.clear()):te=D.buffer.consume(L,D.decoder),te}function ee(L){var D=L._readableState;c("endReadable",D.endEmitted),D.endEmitted||(D.ended=!0,process.nextTick(J,D,L))}function J(L,D){if(c("endReadableNT",L.endEmitted,L.length),!L.endEmitted&&L.length===0&&(L.endEmitted=!0,D.readable=!1,D.emit("end"),L.autoDestroy)){var te=D._writableState;(!te||te.autoDestroy&&te.finished)&&D.destroy()}}typeof Symbol=="function"&&(F.from=function(L,D){return E===void 0&&(E=_9()),E(F,L,D)});function fe(L,D){for(var te=0,le=L.length;te<le;te++)if(L[te]===D)return te;return-1}return r0}var i0,Px;function Lx(){if(Px)return i0;Px=1,i0=a;var t=Ro().codes,e=t.ERR_METHOD_NOT_IMPLEMENTED,n=t.ERR_MULTIPLE_CALLBACK,r=t.ERR_TRANSFORM_ALREADY_TRANSFORMING,o=t.ERR_TRANSFORM_WITH_LENGTH_0,i=Fo();_o()(a,i);function s(u,f){var d=this._transformState;d.transforming=!1;var h=d.writecb;if(h===null)return this.emit("error",new n);d.writechunk=null,d.writecb=null,f!=null&&this.push(f),h(u);var p=this._readableState;p.reading=!1,(p.needReadable||p.length<p.highWaterMark)&&this._read(p.highWaterMark)}function a(u){if(!(this instanceof a))return new a(u);i.call(this,u),this._transformState={afterTransform:s.bind(this),needTransform:!1,transforming:!1,writecb:null,writechunk:null,writeencoding:null},this._readableState.needReadable=!0,this._readableState.sync=!1,u&&(typeof u.transform=="function"&&(this._transform=u.transform),typeof u.flush=="function"&&(this._flush=u.flush)),this.on("prefinish",c)}function c(){var u=this;typeof 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o0,Ox;function R9(){if(Ox)return o0;Ox=1,o0=e;var t=Lx();_o()(e,t);function e(n){if(!(this instanceof e))return new e(n);t.call(this,n)}return e.prototype._transform=function(n,r,o){o(null,n)},o0}var s0,Nx;function F9(){if(Nx)return s0;Nx=1;var t;function e(d){var h=!1;return function(){h||(h=!0,d.apply(void 0,arguments))}}var n=Ro().codes,r=n.ERR_MISSING_ARGS,o=n.ERR_STREAM_DESTROYED;function i(d){if(d)throw d}function s(d){return d.setHeader&&typeof d.abort=="function"}function a(d,h,p,b){b=e(b);var v=!1;d.on("close",function(){v=!0}),t===void 0&&(t=e0()),t(d,{readable:h,writable:p},function(A){if(A)return b(A);v=!0,b()});var y=!1;return function(A){if(!v&&!y){if(y=!0,s(d))return d.abort();if(typeof d.destroy=="function")return d.destroy();b(A||new o("pipe"))}}}function c(d){d()}function l(d,h){return d.pipe(h)}function u(d){return!d.length||typeof d[d.length-1]!="function"?i:d.pop()}function f(){for(var d=arguments.length,h=new Array(d),p=0;p<d;p++)h[p]=arguments[p];var b=u(h);if(Array.isArray(h[0])&&(h=h[0]),h.length<2)throw new r("streams");var v,y=h.map(function(A,S){var E=S<h.length-1,I=S>0;return a(A,E,I,function(_){v||(v=_),_&&y.forEach(c),!E&&(y.forEach(c),b(v))})});return h.reduce(l)}return s0=f,s0}var a0,zx;function M9(){if(zx)return a0;zx=1,a0=n;var t=Hd().EventEmitter,e=_o();e(n,t),n.Readable=Mx(),n.Writable=Ix(),n.Duplex=Fo(),n.Transform=Lx(),n.PassThrough=R9(),n.finished=e0(),n.pipeline=F9(),n.Stream=n;function n(){t.call(this)}return n.prototype.pipe=function(r,o){var i=this;function s(h){r.writable&&r.write(h)===!1&&i.pause&&i.pause()}i.on("data",s);function a(){i.readable&&i.resume&&i.resume()}r.on("drain",a),!r._isStdio&&(!o||o.end!==!1)&&(i.on("end",l),i.on("close",u));var c=!1;function l(){c||(c=!0,r.end())}function u(){c||(c=!0,typeof r.destroy=="function"&&r.destroy())}function f(h){if(d(),t.listenerCount(this,"error")===0)throw h}i.on("error",f),r.on("error",f);function d(){i.removeListener("data",s),r.removeListener("drain",a),i.removeListener("end",l),i.removeListener("close",u),i.removeListener("error",f),r.removeListener("error",f),i.removeListener("end",d),i.removeListener("close",d),r.removeListener("close",d)}return i.on("end",d),i.on("close",d),r.on("close",d),r.emit("pipe",i),r},a0}var Ux=M9(),P9=Jd();function _a(t){return t.replace(/%([0-9A-Fa-f]{2})/g,(e,n)=>String.fromCharCode(parseInt(n,16)))}function Gx(t,e){return String(e).replace(t,n=>`%${n.charCodeAt(0).toString(16).toUpperCase().padStart(2,"0")}`)}function Ra(t){return Gx(/[\n;\r\t=%&,\x00-\x1f\x7f-\xff]/g,t)}function rr(t){return Gx(/[\n\r\t%\x00-\x1f\x7f-\xff]/g,t)}function Hx(t){if(!(t&&t.length)||t===".")return{};const e={};return t.replace(/\r?\n$/,"").split(";").forEach(n=>{const r=n.split("=",2);if(!(r[1]&&r[1].length))return;r[0]=r[0].trim();let o=e[r[0].trim()];o||(o=[],e[r[0]]=o),o.push(...r[1].split(",").map(i=>i.trim()).map(_a))}),e}function Vx(t){const e=t.split(" ").map(r=>r==="."||r===""?null:r);return{seq_id:e[0]&&_a(e[0]),source:e[1]&&_a(e[1]),type:e[2]&&_a(e[2]),start:e[3]===null?null:parseInt(e[3],10),end:e[4]===null?null:parseInt(e[4],10),score:e[5]===null?null:parseFloat(e[5]),strand:e[6],phase:e[7],attributes:e[8]===null?null:Hx(e[8])}}function qx(t){const e=/^\s*##\s*(\S+)\s*(.*)/.exec(t);if(!e)return null;const[,n]=e;let[,,r]=e;const o={directive:n};if(r.length&&(r=r.replace(/\r?\n$/,""),o.value=r),n==="sequence-region"){const i=r.split(/\s+/,3);return{...o,seq_id:i[0],start:i[1]&&i[1].replace(/\D/g,""),end:i[2]&&i[2].replace(/\D/g,"")}}else if(n==="genome-build"){const[i,s]=r.split(/\s+/,2);return{...o,source:i,buildName:s}}return o}function jx(t){const e=[];return Object.entries(t).forEach(([n,r])=>{if(!r)return;let o;r.hasOwnProperty("toString")?o=Ra(r.toString()):Array.isArray(r)?o=r.map(Ra).join(","):o=Ra(r),e.push(`${Ra(n)}=${o}`)}),e.length?e.join(";"):"."}function L9(t,e){const n=t.attributes===null||t.attributes===void 0?".":jx(t.attributes),o=`${[t.seq_id===null?".":rr(t.seq_id),t.source===null?".":rr(t.source),t.type===null?".":rr(t.type),t.start===null?".":rr(t.start),t.end===null?".":rr(t.end),t.score===null?".":rr(t.score),t.strand===null?".":rr(t.strand),t.phase===null?".":rr(t.phase),n].join(" ")}
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`;return e[o]?"":(e[o]=!0,o)}function iu(t,e){if(Array.isArray(t))return t.map(r=>iu(r,e)).join("");const n=[L9(t,e)];return O9(t)&&n.push(...t.child_features.map(r=>iu(r,e)),...t.derived_features.map(r=>iu(r,e))),n.join("")}function Wx(t){return iu(t,{})}function Yx(t){let e=`##${t.directive}`;return t.value&&(e+=` ${t.value}`),e+=`
|
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`,e}function Qx(t){return`# ${t.comment}
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819
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`}function c0(t){return`>${t.id}${t.description?` ${t.description}`:""}
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@@ -827,4 +827,4 @@ ${t.sequence}
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827
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`&&(i+=1);this.linesSinceLastSyncMark+=i}this.haveWeEmittedData=!0,l0(r)}}function V9(t={}){return new $x(t)}function q9(t,e,n={}){const r={insertVersionDirective:!0,...n};return new Promise((o,i)=>{t.pipe(new $x(r)).on("end",()=>o(null)).on("error",i).pipe(e)})}const j9=Object.freeze(Object.defineProperty({__proto__:null,default:{parseStream:U9,parseStringSync:G9,formatSync:H9,formatStream:V9,formatFile:q9,util:N9}},Symbol.toStringTag,{value:"Module"})),su={InfoFields:{AA:{Number:1,Type:"String",Description:"Ancestral allele"},AC:{Number:"A",Type:"Integer",Description:"Allele count in genotypes, for each ALT allele, in the same order as listed"},AD:{Number:"R",Type:"Integer",Description:"Total read depth for each allele"},ADF:{Number:"R",Type:"Integer",Description:"Read depth for each allele on the forward strand"},ADR:{Number:"R",Type:"Integer",Description:"Read depth for each allele on the reverse strand"},AF:{Number:"A",Type:"Float",Description:"Allele frequency for each ALT allele in the same order as listed (estimated from primary data, not called genotypes)"},AN:{Number:1,Type:"Integer",Description:"Total number of alleles in called genotypes"},BQ:{Number:1,Type:"Float",Description:"RMS base quality"},CIGAR:{Number:1,Type:"Float",Description:"Cigar string describing how to align an alternate allele to the reference allele"},DB:{Number:0,Type:"Flag",Description:"dbSNP membership"},DP:{Number:1,Type:"Integer",Description:"combined depth across samples"},END:{Number:1,Type:"Integer",Description:"End position (for use with symbolic alleles)"},H2:{Number:0,Type:"Flag",Description:"HapMap2 membership"},H3:{Number:0,Type:"Flag",Description:"HapMap3 membership"},MQ:{Number:1,Type:null,Description:"RMS mapping quality"},MQ0:{Number:1,Type:"Integer",Description:"Number of MAPQ == 0 reads"},NS:{Number:1,Type:"Integer",Description:"Number of samples with data"},SB:{Number:4,Type:"Integer",Description:"Strand bias"},SOMATIC:{Number:0,Type:"Flag",Description:"Somatic mutation (for cancer genomics)"},VALIDATED:{Number:0,Type:"Flag",Description:"Validated by follow-up experiment"},"1000G":{Number:0,Type:"Flag",Description:"1000 Genomes membership"},IMPRECISE:{Number:0,Type:"Flag",Description:"Imprecise structural variation"},NOVEL:{Number:0,Type:"Flag",Description:"Indicates a novel structural variation"},SVTYPE:{Number:1,Type:"String",Description:"Type of structural variant"},SVLEN:{Number:null,Type:"Integer",Description:"Difference in length between REF and ALT alleles"},CIPOS:{Number:2,Type:"Integer",Description:"Confidence interval around POS for imprecise variants"},CIEND:{Number:2,Type:"Integer",Description:"Confidence interval around END for imprecise variants"},HOMLEN:{Type:"Integer",Description:"Length of base pair identical micro-homology at event breakpoints"},HOMSEQ:{Type:"String",Description:"Sequence of base pair identical micro-homology at event breakpoints"},BKPTID:{Type:"String",Description:"ID of the assembled alternate allele in the assembly file"},MEINFO:{Number:4,Type:"String",Description:"Mobile element info of the form NAME,START,END,POLARITY"},METRANS:{Number:4,Type:"String",Description:"Mobile element transduction info of the form CHR,START,END,POLARITY"},DGVID:{Number:1,Type:"String",Description:"ID of this element in Database of Genomic Variation"},DBVARID:{Number:1,Type:"String",Description:"ID of this element in DBVAR"},DBRIPID:{Number:1,Type:"String",Description:"ID of this element in DBRIP"},MATEID:{Number:null,Type:"String",Description:"ID of mate breakends"},PARID:{Number:1,Type:"String",Description:"ID of partner breakend"},EVENT:{Number:1,Type:"String",Description:"ID of event associated to breakend"},CILEN:{Number:2,Type:"Integer",Description:"Confidence interval around the inserted material between breakend"},DPADJ:{Type:"Integer",Description:"Read Depth of adjacency"},CN:{Number:1,Type:"Integer",Description:"Copy number of segment containing breakend"},CNADJ:{Number:null,Type:"Integer",Description:"Copy number of adjacency"},CICN:{Number:2,Type:"Integer",Description:"Confidence interval around copy number for the segment"},CICNADJ:{Number:null,Type:"Integer",Description:"Confidence interval around copy number for the adjacency"}},GenotypeFields:{AD:{Number:"R",Type:"Integer",Description:"Read depth for each allele"},ADF:{Number:"R",Type:"Integer",Description:"Read depth for each allele on the forward strand"},ADR:{Number:"R",Type:"Integer",Description:"Read depth for each allele on the reverse strand"},DP:{Number:1,Type:"Integer",Description:"Read depth"},EC:{Number:"A",Type:"Integer",Description:"Expected alternate allele counts"},FT:{Number:1,Type:"String",Description:'Filter indicating if this genotype was "called"'},GL:{Number:"G",Type:"Float",Description:"Genotype likelihoods"},GP:{Number:"G",Type:"Float",Description:"Genotype posterior probabilities"},GQ:{Number:1,Type:"Integer",Description:"Conditional genotype quality"},GT:{Number:1,Type:"String",Description:"Genotype"},HQ:{Number:2,Type:"Integer",Description:"Haplotype quality"},MQ:{Number:1,Type:"Integer",Description:"RMS mapping quality"},PL:{Number:"G",Type:"Integer",Description:"Phred-scaled genotype likelihoods rounded to the closest integer"},PQ:{Number:1,Type:"Integer",Description:"Phasing quality"},PS:{Number:1,Type:"Integer",Description:"Phase set"}},AltTypes:{DEL:{Description:"Deletion relative to the reference"},INS:{Description:"Insertion of novel sequence relative to the reference"},DUP:{Description:"Region of elevated copy number relative to the reference"},INV:{Description:"Inversion of reference sequence"},CNV:{Description:"Copy number variable region (may be both deletion and duplication)"},"DUP:TANDEM":{Description:"Tandem duplication"},"DEL:ME":{Description:"Deletion of mobile element relative to the reference"},"INS:ME":{Description:"Insertion of a mobile element relative to the reference"},NON_REF:{Description:"Represents any possible alternative allele at this location"},"*":{Description:"Represents any possible alternative allele at this location"}},FilterTypes:{PASS:{Description:"Passed all filters"}}};function W9(t){try{return decodeURIComponent(t)}catch{return t}}class Y9{constructor({header:e="",strict:n=!0}){if(!e.length)throw new Error("empty header received");const r=e.split(/[\r\n]+/).filter(c=>c);if(!r.length)throw new Error("no non-empty header lines specified");this.strict=n,this.metadata=JSON.parse(JSON.stringify({INFO:su.InfoFields,FORMAT:su.GenotypeFields,ALT:su.AltTypes,FILTER:su.FilterTypes}));let o;if(r.forEach(c=>{if(c.startsWith("#"))c.startsWith("##")?this.parseMetadata(c):o=c;else throw new Error(`Bad line in header:
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${c}`)}),!o)throw new Error("No format line found in header");const i=o.trim().split(" "),s=i.slice(0,8),a=["#CHROM","POS","ID","REF","ALT","QUAL","FILTER","INFO"];if(i.length<8)throw new Error(`VCF header missing columns:
|
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${o}`);if(s.length!==a.length||!s.every((c,l)=>c===a[l]))throw new Error(`VCF column headers not correct:
|
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830
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-
${o}`);this.samples=i.slice(9)}parseSamples(e,n){const r={};if(e){const o=n.split(" "),i=e.split(":"),s=i.map(a=>{const c=this.getMetadata("FORMAT",a,"Type");return c==="Integer"||c==="Float"});for(let a=0;a<this.samples.length;a++){const c=this.samples[a];r[c]={};const l=o[a].split(":");for(let u=0;u<l.length;u++){const f=l[u];r[c][i[u]]=f===""||f==="."?void 0:f.split(",").map(d=>d==="."?void 0:s[u]?+d:d)}}}return r}parseGenotypesOnly(e,n){const r=n.split(" "),o={};let i=0;const s=e.split(":");if(s.length===1)for(const a of this.samples)o[a]=r[i++];else{const a=s.findIndex(c=>c==="GT");if(a===0)for(const c of this.samples){const l=r[i++],u=l.indexOf(":");u!==-1?o[c]=l.slice(0,u):console.warn("unknown")}else for(const c of this.samples){const l=r[i++].split(":");o[c]=l[a]}}return o}parseMetadata(e){const n=/^##(.+?)=(.*)/.exec(e.trim());if(!n)throw new Error(`Line is not a valid metadata line: ${e}`);const[r,o]=n.slice(1,3),i=r;if(o!=null&&o.startsWith("<")){i in this.metadata||(this.metadata[i]={});const[s,a]=this.parseStructuredMetaVal(o);this.metadata[i][s]=a}else this.metadata[i]=o}parseStructuredMetaVal(e){const n=this.parseKeyValue(e.replace(/^<|>$/g,""),","),r=n.ID;return delete n.ID,"Number"in n&&(Number.isNaN(Number(n.Number))||(n.Number=Number(n.Number))),[r,n]}getMetadata(...e){let n=this.metadata;for(const r of e)if(n=n[r],!n)return n;return n}parseKeyValue(e,n=";"){const r={};let o="",i="",s=1;for(const a of e)s===1?a==="="?s=2:a!==n?o+=a:i===""&&(r[o]=void 0,o=""):s===2?a===n?(r[o]=i,o="",i="",s=1):a==='"'?s=3:i+=a:s===3&&(a!=='"'?i+=a:s=2);return s===2||s===3?r[o]=i:s===1&&(r[o]=void 0),r}parseLine(e){var n,r;let o=0;for(let B=0;o<e.length&&(e[o]===" "&&(B+=1),B!==9);o+=1);const i=e.slice(0,o).split(" "),s=e.slice(o+1),[a,c,l,u,f,d,h]=i,p=a,b=+c,v=l==="."?void 0:l.split(";"),y=u,A=f==="."?void 0:f.split(","),S=d==="."?void 0:+d,E=h==="."?void 0:h.split(";");if(this.strict&&!i[7])throw new Error("no INFO field specified, must contain at least a '.' (turn off strict mode to allow)");const I=(n=i[7])===null||n===void 0?void 0:n.includes("%"),_=i[7]===void 0||i[7]==="."?{}:this.parseKeyValue(i[7]);for(const B of Object.keys(_)){const N=(r=_[B])===null||r===void 0?void 0:r.split(",").map(
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830
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+
${o}`);this.samples=i.slice(9)}parseSamples(e,n){const r={};if(e){const o=n.split(" "),i=e.split(":"),s=i.map(a=>{const c=this.getMetadata("FORMAT",a,"Type");return c==="Integer"||c==="Float"});for(let a=0;a<this.samples.length;a++){const c=this.samples[a];r[c]={};const l=o[a].split(":");for(let u=0;u<l.length;u++){const f=l[u];r[c][i[u]]=f===""||f==="."?void 0:f.split(",").map(d=>d==="."?void 0:s[u]?+d:d)}}}return r}parseGenotypesOnly(e,n){const r=n.split(" "),o={};let i=0;const s=e.split(":");if(s.length===1)for(const a of this.samples)o[a]=r[i++];else{const a=s.findIndex(c=>c==="GT");if(a===0)for(const c of this.samples){const l=r[i++],u=l.indexOf(":");u!==-1?o[c]=l.slice(0,u):console.warn("unknown")}else for(const c of this.samples){const l=r[i++].split(":");o[c]=l[a]}}return o}parseMetadata(e){const n=/^##(.+?)=(.*)/.exec(e.trim());if(!n)throw new Error(`Line is not a valid metadata line: ${e}`);const[r,o]=n.slice(1,3),i=r;if(o!=null&&o.startsWith("<")){i in this.metadata||(this.metadata[i]={});const[s,a]=this.parseStructuredMetaVal(o);this.metadata[i][s]=a}else this.metadata[i]=o}parseStructuredMetaVal(e){const n=this.parseKeyValue(e.replace(/^<|>$/g,""),","),r=n.ID;return delete n.ID,"Number"in n&&(Number.isNaN(Number(n.Number))||(n.Number=Number(n.Number))),[r,n]}getMetadata(...e){let n=this.metadata;for(const r of e)if(n=n[r],!n)return n;return n}parseKeyValue(e,n=";"){const r={};let o="",i="",s=1;for(const a of e)s===1?a==="="?s=2:a!==n?o+=a:i===""&&(r[o]=void 0,o=""):s===2?a===n?(r[o]=i,o="",i="",s=1):a==='"'?s=3:i+=a:s===3&&(a!=='"'?i+=a:s=2);return s===2||s===3?r[o]=i:s===1&&(r[o]=void 0),r}parseLine(e){var n,r;let o=0;for(let B=0;o<e.length&&(e[o]===" "&&(B+=1),B!==9);o+=1);const i=e.slice(0,o).split(" "),s=e.slice(o+1),[a,c,l,u,f,d,h]=i,p=a,b=+c,v=l==="."?void 0:l.split(";"),y=u,A=f==="."?void 0:f.split(","),S=d==="."?void 0:+d,E=h==="."?void 0:h.split(";");if(this.strict&&!i[7])throw new Error("no INFO field specified, must contain at least a '.' (turn off strict mode to allow)");const I=(n=i[7])===null||n===void 0?void 0:n.includes("%"),_=i[7]===void 0||i[7]==="."?{}:this.parseKeyValue(i[7]);for(const B of Object.keys(_)){const N=(r=_[B])===null||r===void 0?void 0:r.split(",").map(M=>M==="."?void 0:M).map(M=>M&&I?W9(M):M),F=this.getMetadata("INFO",B,"Type");F==="Integer"||F==="Float"?_[B]=N==null?void 0:N.map(M=>M===void 0?void 0:Number(M)):F==="Flag"?_[B]=!0:_[B]=N}return{CHROM:p,POS:b,ALT:A,INFO:_,REF:y,FILTER:E&&E.length===1&&E[0]==="PASS"?"PASS":E,ID:v,QUAL:S,SAMPLES:()=>{var B;return this.parseSamples((B=i[8])!==null&&B!==void 0?B:"",s)},GENOTYPES:()=>{var B;return this.parseGenotypesOnly((B=i[8])!==null&&B!==void 0?B:"",s)}}}}const Q9=Object.freeze(Object.defineProperty({__proto__:null,default:Y9},Symbol.toStringTag,{value:"Module"}));ze.GenomeSpy=Gy,ze.embed=h_,ze.favIcon=f_,ze.html=ot,ze.icon=u_,ze.loadSpec=Hy,Object.defineProperty(ze,Symbol.toStringTag,{value:"Module"})});
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