@erosolaraijs/cure 2.3.0 → 2.4.0

package/dist/capabilities/emergencyOncology.js.map

@@ -0,0 +1 @@
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package/dist/capabilities/index.d.ts

@@ -19,4 +19,15 @@
 export { CancerTreatmentCapabilityModule, type CancerTreatmentOperationType, type CancerPatient, type CancerTreatmentOperation, type CancerTreatmentResult, type TreatmentProtocol } from './cancerTreatmentCapability.js';
 export { GlobalCancerCoverageModule, type GlobalTreatmentGuideline, type SpecialPopulationProtocol, type ResourceLimitedAdaptation, type RareCancerProtocol, type SupportiveCareProtocol, type PediatricOncologyProtocol } from './globalCancerCoverage.js';
 export { EmergingTherapeuticsModule, type EmergingTherapy, type NovelTarget, type NextGenCellularTherapy, type ProteinDegrader, type RadiopharmaceuticalTherapy, type AIDiscoveredDrug } from './emergingTherapeutics.js';
+export { CureValidationFramework, COMPLETE_CANCER_TAXONOMY, CURE_CRITERIA_DATABASE, type CancerCoverageValidation, type TreatmentOutcomeValidation, type CureCriteria, type CureVerification, type ComprehensiveCoverageReport } from './cureValidationFramework.js';
+export { ResistanceManagementEngine, resistanceManagementEngine, CureVerificationEngine, cureVerificationEngine, RESISTANCE_MECHANISM_DATABASE, RESISTANCE_MONITORING_PROTOCOLS, type ResistanceMechanism, type OvercomingStrategy, type ResistanceMonitoringPlan, type CureVerificationResult } from './resistanceManagement.js';
+export { TreatmentSequencingEngine, treatmentSequencingEngine, NSCLC_TREATMENT_SEQUENCES, BREAST_CANCER_TREATMENT_SEQUENCES, COLORECTAL_CANCER_TREATMENT_SEQUENCES, type TreatmentLine, type TherapyRegimen, type DrugComponent, type SelectionCriteria, type BiomarkerRequirement, type ResponseAssessment, type SwitchingCriteria, type CancerTreatmentSequence, type SpecialPathway, type MaintenanceProtocol, type RechallengeProtocol } from './treatmentSequencing.js';
+export { EmergencyOncologyEngine, emergencyOncologyEngine, STRUCTURAL_EMERGENCIES, METABOLIC_EMERGENCIES, TREATMENT_RELATED_EMERGENCIES, HEMATOLOGIC_EMERGENCIES, type OncologicEmergency, type EmergencyCategory, type RecognitionCriteria, type EmergencyManagement, type MedicationOrder, type DefinitiveManagement, type MonitoringProtocol, type OutcomeExpectations } from './emergencyOncology.js';
+export { SurvivorshipCareEngine, survivorshipCareEngine, SURVEILLANCE_PROTOCOLS, LATE_EFFECTS_PROTOCOLS, SECONDARY_MALIGNANCY_SCREENING, PSYCHOSOCIAL_SUPPORT_FRAMEWORK, EXERCISE_RECOMMENDATIONS, HEALTH_MAINTENANCE_RECOMMENDATIONS, type SurvivorshipCareplan, type TreatmentSummary, type SurgicalSummary, type RadiationSummary, type SystemicTherapySummary, type SurveillanceProtocol, type SurveillanceVisit, type LateEffectsScreening, type LateEffectRisk, type SecondaryMalignancyScreen, type PsychosocialPlan, type RehabilitationPlan, type ExerciseRecommendation, type HealthMaintenance } from './survivorshipManagement.js';
+export { UniversalCancerCureEngine, universalCancerCureEngine, COMPREHENSIVE_CANCER_TAXONOMY, ACTIONABLE_BIOMARKERS, SPECIAL_POPULATION_PROTOCOLS, type ComprehensiveBiomarkerPanel, type TreatmentPathway, type TreatmentLine as UnifiedTreatmentLine, type TreatmentRegimen as UnifiedTreatmentRegimen, type ResponseMonitoring, type ResistanceStrategy, type UniversalCureResult } from './universalCancerCureEngine.js';
+export { PalliativeCareEngine, palliativeCareEngine, WHO_PAIN_LADDER, NEUROPATHIC_PAIN_PROTOCOLS, CIPN_PROTOCOLS, BONE_PAIN_PROTOCOL, CANCER_SYMPTOM_CLUSTERS, END_OF_LIFE_PROTOCOLS, PALLIATIVE_SEDATION_PROTOCOL, OPIOID_EQUIVALENCE_TABLE, type PainAssessment, type PainManagementProtocol, type PainIntervention, type CIPNProtocol, type SymptomCluster, type EndOfLifeProtocol, type OpioidEquivalence } from './palliativeCareModule.js';
+export { PrecisionMedicineEngine, precisionMedicineEngine, ACTIONABLE_GENOMIC_DATABASE, PHARMACOGENOMIC_MARKERS, TME_THERAPEUTIC_IMPLICATIONS, type GenomicAlteration, type ActionabilityLevel, type TargetedTherapy, type PharmacogenomicMarker, type TumorMicroenvironment, type LiquidBiopsyResult, type CtDNAInterpretation } from './precisionMedicineModule.js';
+export { MultimodalOncologyEngine, multimodalOncologyEngine, RADIATION_PROTOCOLS, SURGICAL_PROTOCOLS, MULTIMODAL_SEQUENCES, type RadiationProtocol, type RadiationTechnique, type FractionationScheme, type OARConstraint, type SurgicalProcedure, type SurgicalApproach, type MultimodalSequence } from './multimodalOncologyModule.js';
+export { ClinicalTrialMatchingEngine, clinicalTrialMatchingEngine, TRIAL_DATABASE, type ClinicalTrial, type TrialPhase, type TrialIntervention, type EligibilityCriteria, type TrialLocation, type PatientTrialProfile, type TrialMatch } from './clinicalTrialMatchingModule.js';
+export { SpecialPopulationsEngine, specialPopulationsEngine, PEDIATRIC_DOSING_PROTOCOLS, COMPREHENSIVE_GERIATRIC_ASSESSMENT, GERIATRIC_DOSING_ADJUSTMENTS, PREGNANCY_CANCER_PROTOCOLS, ORGAN_DYSFUNCTION_DOSING, HIV_ONCOLOGY_PROTOCOLS, calculateBSA, calculatePediatricDose, type PediatricDosingProtocol, type GeriatricAssessment, type GeriatricDosingAdjustment, type PregnancyCancerProtocol, type OrganDysfunctionDosing, type HIVOncologyProtocol } from './specialPopulationsModule.js';
 //# sourceMappingURL=index.d.ts.map

package/dist/capabilities/index.d.ts.map

@@ -1 +1 @@
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package/dist/capabilities/index.js

@@ -22,4 +22,26 @@ export { CancerTreatmentCapabilityModule } from './cancerTreatmentCapability.js'
 export { GlobalCancerCoverageModule } from './globalCancerCoverage.js';
 // Emerging Therapeutics - Cutting-edge treatments and novel targets
 export { EmergingTherapeuticsModule } from './emergingTherapeutics.js';
+// Cure Validation Framework - Verify cure status and coverage completeness
+export { CureValidationFramework, COMPLETE_CANCER_TAXONOMY, CURE_CRITERIA_DATABASE } from './cureValidationFramework.js';
+// Resistance Management - Overcome all treatment resistance mechanisms
+export { ResistanceManagementEngine, resistanceManagementEngine, CureVerificationEngine, cureVerificationEngine, RESISTANCE_MECHANISM_DATABASE, RESISTANCE_MONITORING_PROTOCOLS } from './resistanceManagement.js';
+// Treatment Sequencing - Optimal line-of-therapy protocols
+export { TreatmentSequencingEngine, treatmentSequencingEngine, NSCLC_TREATMENT_SEQUENCES, BREAST_CANCER_TREATMENT_SEQUENCES, COLORECTAL_CANCER_TREATMENT_SEQUENCES } from './treatmentSequencing.js';
+// Emergency Oncology - Life-saving protocols for oncologic emergencies
+export { EmergencyOncologyEngine, emergencyOncologyEngine, STRUCTURAL_EMERGENCIES, METABOLIC_EMERGENCIES, TREATMENT_RELATED_EMERGENCIES, HEMATOLOGIC_EMERGENCIES } from './emergencyOncology.js';
+// Survivorship Management - Long-term care and late effects
+export { SurvivorshipCareEngine, survivorshipCareEngine, SURVEILLANCE_PROTOCOLS, LATE_EFFECTS_PROTOCOLS, SECONDARY_MALIGNANCY_SCREENING, PSYCHOSOCIAL_SUPPORT_FRAMEWORK, EXERCISE_RECOMMENDATIONS, HEALTH_MAINTENANCE_RECOMMENDATIONS } from './survivorshipManagement.js';
+// Universal Cancer Cure Engine - Complete integration of all capabilities
+export { UniversalCancerCureEngine, universalCancerCureEngine, COMPREHENSIVE_CANCER_TAXONOMY, ACTIONABLE_BIOMARKERS, SPECIAL_POPULATION_PROTOCOLS } from './universalCancerCureEngine.js';
+// Palliative Care - Comprehensive pain and symptom management
+export { PalliativeCareEngine, palliativeCareEngine, WHO_PAIN_LADDER, NEUROPATHIC_PAIN_PROTOCOLS, CIPN_PROTOCOLS, BONE_PAIN_PROTOCOL, CANCER_SYMPTOM_CLUSTERS, END_OF_LIFE_PROTOCOLS, PALLIATIVE_SEDATION_PROTOCOL, OPIOID_EQUIVALENCE_TABLE } from './palliativeCareModule.js';
+// Precision Medicine - Genomic interpretation and biomarker-driven therapy
+export { PrecisionMedicineEngine, precisionMedicineEngine, ACTIONABLE_GENOMIC_DATABASE, PHARMACOGENOMIC_MARKERS, TME_THERAPEUTIC_IMPLICATIONS } from './precisionMedicineModule.js';
+// Multimodal Oncology - Radiation and Surgical Integration
+export { MultimodalOncologyEngine, multimodalOncologyEngine, RADIATION_PROTOCOLS, SURGICAL_PROTOCOLS, MULTIMODAL_SEQUENCES } from './multimodalOncologyModule.js';
+// Clinical Trial Matching - Connect patients to novel therapies
+export { ClinicalTrialMatchingEngine, clinicalTrialMatchingEngine, TRIAL_DATABASE } from './clinicalTrialMatchingModule.js';
+// Special Populations - Pediatric, Geriatric, Pregnancy, HIV, Organ Dysfunction
+export { SpecialPopulationsEngine, specialPopulationsEngine, PEDIATRIC_DOSING_PROTOCOLS, COMPREHENSIVE_GERIATRIC_ASSESSMENT, GERIATRIC_DOSING_ADJUSTMENTS, PREGNANCY_CANCER_PROTOCOLS, ORGAN_DYSFUNCTION_DOSING, HIV_ONCOLOGY_PROTOCOLS, calculateBSA, calculatePediatricDose } from './specialPopulationsModule.js';
 //# sourceMappingURL=index.js.map

package/dist/capabilities/index.js.map

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package/dist/capabilities/multimodalOncologyModule.d.ts

@@ -0,0 +1,149 @@
+/**
+ * Multimodal Oncology - Radiation and Surgical Oncology Integration
+ *
+ * ╔═══════════════════════════════════════════════════════════════════════════════╗
+ * ║  MULTIMODAL ONCOLOGY - RADIATION AND SURGICAL TREATMENT INTEGRATION          ║
+ * ╠═══════════════════════════════════════════════════════════════════════════════╣
+ * ║  This module provides:                                                        ║
+ * ║  - Radiation oncology protocols and dose calculations                        ║
+ * ║  - Surgical oncology decision support                                        ║
+ * ║  - Multimodal treatment sequencing                                           ║
+ * ║  - Toxicity prediction and management                                        ║
+ * ║  - Re-irradiation considerations                                             ║
+ * ╚═══════════════════════════════════════════════════════════════════════════════╝
+ */
+export interface RadiationProtocol {
+    indication: string;
+    intent: 'Curative' | 'Adjuvant' | 'Neoadjuvant' | 'Palliative' | 'Definitive';
+    technique: RadiationTechnique;
+    fractionation: FractionationScheme[];
+    targetVolumes: TargetVolume[];
+    organAtRiskConstraints: OARConstraint[];
+    combinationTherapy?: ConcurrentTherapy;
+    expectedOutcomes: RadiationOutcome;
+    toxicityProfile: RadiationToxicity;
+}
+export interface RadiationTechnique {
+    modality: 'Photon EBRT' | 'IMRT' | 'VMAT' | 'SBRT/SABR' | 'SRS' | 'Proton' | 'Carbon Ion' | 'Brachytherapy' | 'TBI';
+    deliveryMethod: string;
+    imagingGuidance: string[];
+    motionManagement?: string;
+}
+export interface FractionationScheme {
+    name: string;
+    totalDose: number;
+    fractions: number;
+    dosePerFraction: number;
+    schedule: string;
+    indication: string;
+    biologicalEquivalentDose?: number;
+}
+export interface TargetVolume {
+    name: 'GTV' | 'CTV' | 'PTV' | 'ITV';
+    description: string;
+    margin: string;
+    dose: number;
+}
+export interface OARConstraint {
+    organ: string;
+    constraint: string;
+    toxicityEndpoint: string;
+    priority: 'Hard' | 'Soft';
+}
+export interface ConcurrentTherapy {
+    agent: string;
+    schedule: string;
+    rationale: string;
+    precautions: string[];
+}
+export interface RadiationOutcome {
+    localControl: string;
+    survivalBenefit: string;
+    evidenceBasis: string;
+}
+export interface RadiationToxicity {
+    acute: ToxicityEvent[];
+    late: ToxicityEvent[];
+    managementStrategies: string[];
+}
+export interface ToxicityEvent {
+    type: string;
+    incidence: string;
+    severity: string;
+    timing: string;
+    management: string;
+}
+export declare const RADIATION_PROTOCOLS: Record<string, RadiationProtocol[]>;
+export interface SurgicalProcedure {
+    name: string;
+    indication: string;
+    intent: 'Curative' | 'Debulking' | 'Palliative' | 'Diagnostic' | 'Prophylactic';
+    approach: SurgicalApproach[];
+    oncologicPrinciples: string[];
+    margins: MarginRequirement;
+    lymphNodeAssessment: LymphNodeProtocol;
+    perioperativeConsiderations: PerioperativeProtocol;
+    outcomes: SurgicalOutcome;
+}
+export interface SurgicalApproach {
+    technique: 'Open' | 'Laparoscopic' | 'Robotic' | 'Endoscopic' | 'Percutaneous';
+    advantages: string[];
+    disadvantages: string[];
+    patientSelection: string[];
+}
+export interface MarginRequirement {
+    recommended: string;
+    minimum: string;
+    impactOfPositiveMargin: string;
+}
+export interface LymphNodeProtocol {
+    type: 'Sentinel Node' | 'Regional Dissection' | 'Sampling' | 'None';
+    minimumNodes?: number;
+    technique: string;
+    indication: string;
+}
+export interface PerioperativeProtocol {
+    preoperativeOptimization: string[];
+    erpsProtocol: boolean;
+    vteProhylaxis: string;
+    antibioticProphylaxis: string;
+    nutritionalConsiderations: string;
+    neoadjuvantOptions?: string;
+    adjuvantOptions?: string;
+}
+export interface SurgicalOutcome {
+    mortality: string;
+    morbidity: string;
+    hospitalStay: string;
+    oncologicOutcome: string;
+}
+export declare const SURGICAL_PROTOCOLS: Record<string, SurgicalProcedure[]>;
+export interface MultimodalSequence {
+    cancerType: string;
+    stage: string;
+    sequence: TreatmentPhase[];
+    rationale: string;
+    evidence: string;
+}
+export interface TreatmentPhase {
+    phase: string;
+    modality: 'Surgery' | 'Radiation' | 'Chemotherapy' | 'Targeted Therapy' | 'Immunotherapy' | 'Hormone Therapy';
+    timing: string;
+    details: string;
+}
+export declare const MULTIMODAL_SEQUENCES: MultimodalSequence[];
+export declare class MultimodalOncologyEngine {
+    getRadiationProtocol(site: string): RadiationProtocol[];
+    getSurgicalProtocol(cancerType: string): SurgicalProcedure[];
+    getMultimodalSequence(cancerType: string, stage: string): MultimodalSequence | undefined;
+    calculateBED(totalDose: number, fractions: number, alphabeta?: number): number;
+    assessOperability(performanceStatus: number, comorbidities: string[], cancerType: string): {
+        operable: boolean;
+        approach: string;
+        considerations: string[];
+    };
+    getAllRadiationSites(): string[];
+    getAllSurgicalSites(): string[];
+}
+export declare const multimodalOncologyEngine: MultimodalOncologyEngine;
+//# sourceMappingURL=multimodalOncologyModule.d.ts.map

package/dist/capabilities/multimodalOncologyModule.d.ts.map

@@ -0,0 +1 @@
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