@erosolaraijs/cure 2.3.0 → 2.4.0

package/dist/capabilities/palliativeCareModule.js.map

@@ -0,0 +1 @@
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package/dist/capabilities/precisionMedicineModule.d.ts

@@ -0,0 +1,151 @@
+/**
+ * Precision Medicine and Genomic Interpretation Module
+ *
+ * ╔═══════════════════════════════════════════════════════════════════════════════╗
+ * ║  PRECISION ONCOLOGY - BIOMARKER-DRIVEN TREATMENT SELECTION                  ║
+ * ╠═══════════════════════════════════════════════════════════════════════════════╣
+ * ║  This module provides:                                                        ║
+ * ║  - Comprehensive genomic interpretation                                      ║
+ * ║  - Actionable mutation databases                                             ║
+ * ║  - Pharmacogenomics for toxicity prediction                                  ║
+ * ║  - Tumor microenvironment analysis                                           ║
+ * ║  - ctDNA/liquid biopsy interpretation                                        ║
+ * ║  - Variant actionability scoring                                             ║
+ * ╚═══════════════════════════════════════════════════════════════════════════════╝
+ */
+export interface GenomicAlteration {
+    gene: string;
+    alteration: string;
+    alterationType: AlterationType;
+    frequency: string;
+    cancerTypes: string[];
+    actionability: ActionabilityLevel;
+    therapies: TargetedTherapy[];
+    clinicalTrials: string[];
+    resistance: ResistanceMutation[];
+    prognosticValue: PrognosticValue;
+}
+export type AlterationType = 'Missense Mutation' | 'Nonsense Mutation' | 'Frameshift' | 'In-frame Deletion' | 'In-frame Insertion' | 'Splice Site' | 'Amplification' | 'Deletion' | 'Fusion' | 'Rearrangement' | 'Copy Number Gain' | 'Copy Number Loss';
+export interface ActionabilityLevel {
+    level: 'Level 1' | 'Level 2' | 'Level 3A' | 'Level 3B' | 'Level 4' | 'Not Actionable';
+    description: string;
+    source: string;
+}
+export interface TargetedTherapy {
+    drug: string;
+    class: string;
+    approvalStatus: 'FDA-Approved' | 'EMA-Approved' | 'Off-Label' | 'Clinical Trial';
+    indication: string;
+    responseRate: string;
+    medianPFS: string;
+    keyTrial: string;
+}
+export interface ResistanceMutation {
+    mutation: string;
+    frequency: string;
+    overcomingStrategy: string[];
+}
+export interface PrognosticValue {
+    impact: 'Favorable' | 'Unfavorable' | 'Neutral' | 'Context-Dependent';
+    description: string;
+}
+export declare const ACTIONABLE_GENOMIC_DATABASE: GenomicAlteration[];
+export interface PharmacogenomicMarker {
+    gene: string;
+    variant: string;
+    affectedDrugs: DrugPGx[];
+    testingRecommendation: 'Required' | 'Strongly Recommended' | 'Consider' | 'Optional';
+    guidelineSource: string;
+}
+export interface DrugPGx {
+    drug: string;
+    effect: string;
+    recommendation: string;
+    doseAdjustment?: string;
+}
+export declare const PHARMACOGENOMIC_MARKERS: PharmacogenomicMarker[];
+export interface TumorMicroenvironment {
+    immuneInfiltration: ImmuneInfiltration;
+    stromalPhenotype: StromalPhenotype;
+    vascularization: VascularStatus;
+    immunePhenotype: 'Inflamed' | 'Excluded' | 'Desert';
+    therapeuticImplications: TherapeuticImplication[];
+}
+export interface ImmuneInfiltration {
+    cd8TILs: 'High' | 'Intermediate' | 'Low' | 'Absent';
+    cd4TILs: 'High' | 'Intermediate' | 'Low';
+    tregs: 'High' | 'Low';
+    myeloidCells: MDSCStatus;
+    nkCells: 'Present' | 'Absent';
+    bCells: 'Present' | 'Absent' | 'TLS Present';
+}
+export interface MDSCStatus {
+    mdscLevel: 'High' | 'Low';
+    m1m2Ratio: 'M1-predominant' | 'M2-predominant' | 'Mixed';
+}
+export interface StromalPhenotype {
+    cafPresence: 'High' | 'Low';
+    ecmDensity: 'Dense' | 'Moderate' | 'Loose';
+    fibrosis: boolean;
+}
+export interface VascularStatus {
+    vascularDensity: 'High' | 'Moderate' | 'Low';
+    vascularNormalization: boolean;
+    hypoxia: boolean;
+}
+export interface TherapeuticImplication {
+    finding: string;
+    implication: string;
+    recommendation: string;
+}
+export declare const TME_THERAPEUTIC_IMPLICATIONS: Record<string, TherapeuticImplication[]>;
+export interface LiquidBiopsyResult {
+    sampleDate: string;
+    ctdnaFraction: number;
+    alterationsDetected: CtDNAAlteration[];
+    clinicalInterpretation: CtDNAInterpretation;
+}
+export interface CtDNAAlteration {
+    gene: string;
+    alteration: string;
+    vaf: number;
+    clinicalSignificance: 'Actionable' | 'Resistance' | 'Prognostic' | 'VUS' | 'Benign';
+}
+export interface CtDNAInterpretation {
+    summary: string;
+    actionableFindings: string[];
+    resistanceMutations: string[];
+    monitoringRecommendation: string;
+    tissueConfirmationNeeded: boolean;
+}
+export declare function interpretCtDNA(result: LiquidBiopsyResult): CtDNAInterpretation;
+export declare class PrecisionMedicineEngine {
+    getActionableAlterations(gene: string): GenomicAlteration[];
+    getAlterationByType(alteration: string): GenomicAlteration | undefined;
+    getTherapiesForAlteration(gene: string, alteration: string): TargetedTherapy[];
+    getPharmacogenomicRecommendation(drug: string): PharmacogenomicMarker | undefined;
+    assessActionability(alterations: {
+        gene: string;
+        alteration: string;
+    }[]): {
+        level1: GenomicAlteration[];
+        level2: GenomicAlteration[];
+        level3: GenomicAlteration[];
+        notActionable: string[];
+    };
+    getTMEImplications(phenotype: TumorMicroenvironment['immunePhenotype']): TherapeuticImplication[];
+    interpretLiquidBiopsy(result: LiquidBiopsyResult): CtDNAInterpretation;
+    generatePrecisionReport(patientId: string, genomicProfile: {
+        gene: string;
+        alteration: string;
+        type: string;
+    }[], pharmacogenomics: string[], tmeIfAvailable?: TumorMicroenvironment): {
+        actionableTargets: GenomicAlteration[];
+        pgxRecommendations: PharmacogenomicMarker[];
+        tmeImplications: TherapeuticImplication[];
+        clinicalTrialTargets: string[];
+        summary: string;
+    };
+}
+export declare const precisionMedicineEngine: PrecisionMedicineEngine;
+//# sourceMappingURL=precisionMedicineModule.d.ts.map

package/dist/capabilities/precisionMedicineModule.d.ts.map

@@ -0,0 +1 @@
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