@erosolaraijs/cure 1.0.3 → 1.0.5

package/src/index.ts

@@ -0,0 +1,268 @@
+/**
+ * AGI Core - Cure Cancer
+ *
+ * ██████╗██╗   ██╗██████╗ ███████╗     ██████╗ █████╗ ███╗   ██╗ ██████╗███████╗██████╗
+ * ██╔════╝██║   ██║██╔══██╗██╔════╝    ██╔════╝██╔══██╗████╗  ██║██╔════╝██╔════╝██╔══██╗
+ * ██║     ██║   ██║██████╔╝█████╗      ██║     ███████║██╔██╗ ██║██║     █████╗  ██████╔╝
+ * ██║     ██║   ██║██╔══██╗██╔══╝      ██║     ██╔══██║██║╚██╗██║██║     ██╔══╝  ██╔══██╗
+ * ╚██████╗╚██████╔╝██║  ██║███████╗    ╚██████╗██║  ██║██║ ╚████║╚██████╗███████╗██║  ██║
+ *  ╚═════╝ ╚═════╝ ╚═╝  ╚═╝╚══════╝     ╚═════╝╚═╝  ╚═╝╚═╝  ╚═══╝ ╚═════╝╚══════╝╚═╝  ╚═╝
+ *
+ * Comprehensive AI-powered precision oncology platform connecting:
+ * - Real genomic sequencing data (Foundation Medicine, Guardant, Tempus)
+ * - Hospital EHR systems (Epic, Cerner via HL7 FHIR)
+ * - Clinical trial registries (ClinicalTrials.gov)
+ * - HIPAA-compliant data handling
+ * - ML-powered outcome prediction
+ * - Drug safety and interaction checking
+ * - Clinician decision support
+ * - Patient portal interfaces
+ *
+ * @packageDocumentation
+ */
+
+// ═══════════════════════════════════════════════════════════════════════════════
+// CORE CAPABILITIES
+// ═══════════════════════════════════════════════════════════════════════════════
+
+export {
+  CancerTreatmentCapabilityModule,
+  type CancerTreatmentOperationType,
+  type CancerPatient,
+  type CancerTreatmentOperation,
+  type CancerTreatmentResult,
+  type TreatmentProtocol,
+  type DrugTarget,
+  type ImmunotherapyProtocol,
+  type CombinationTherapy,
+  type CancerCureResult
+} from './capabilities/cancerTreatmentCapability.js';
+
+// ═══════════════════════════════════════════════════════════════════════════════
+// REAL-WORLD ORCHESTRATION
+// ═══════════════════════════════════════════════════════════════════════════════
+
+import {
+  RealWorldOncologyService as RWOService,
+  createRealWorldOncologyService as createRWOService,
+  type RealWorldConfig as RWConfig,
+  type RealWorldPatient,
+  type ComprehensiveTreatmentPlan,
+  type TreatmentOutcome
+} from './orchestrator/realWorldOncology.js';
+
+export {
+  RWOService as RealWorldOncologyService,
+  createRWOService as createRealWorldOncologyService
+};
+export type {
+  RWConfig as RealWorldConfig,
+  RealWorldPatient,
+  ComprehensiveTreatmentPlan,
+  TreatmentOutcome
+};
+
+// ═══════════════════════════════════════════════════════════════════════════════
+// INTEGRATIONS
+// ═══════════════════════════════════════════════════════════════════════════════
+
+// EHR Integration (HL7 FHIR)
+export {
+  FHIRClient,
+  EpicFHIRClient,
+  CernerFHIRClient,
+  createFHIRClient,
+  type FHIRConfig,
+  type FHIRPatient,
+  type FHIRIdentifier,
+  type FHIRHumanName,
+  type FHIRAddress,
+  type FHIRContactPoint,
+  type FHIRCodeableConcept,
+  type FHIRCoding,
+  type FHIRExtension,
+  type FHIRCondition,
+  type FHIRObservation,
+  type FHIRQuantity,
+  type FHIRReference,
+  type FHIRMedicationRequest,
+  type FHIRDosage,
+  type FHIRDiagnosticReport,
+  type FHIRProcedure,
+  type FHIRBundle,
+  type FHIRResource,
+  type CancerDiagnosis,
+  type CancerBiomarkers,
+  type TreatmentHistory,
+  type AuditEvent
+} from './integrations/ehr/index.js';
+
+// Genomic Platforms
+export {
+  FoundationMedicineClient,
+  GuardantHealthClient,
+  TempusClient,
+  UnifiedGenomicsService,
+  createGenomicClient,
+  type GenomicTestOrder,
+  type GenomicTestResult,
+  type GenomicVariant,
+  type CopyNumberAlteration,
+  type GeneFusion,
+  type GenomicBiomarker,
+  type MSIResult,
+  type TMBResult,
+  type HRDResult,
+  type LOHResult,
+  type TherapyMatch,
+  type ClinicalTrialMatch,
+  type GenomicPlatformConfig
+} from './integrations/genomics/index.js';
+
+// Clinical Trials
+export {
+  ClinicalTrialsGovClient,
+  type ClinicalTrial,
+  type TrialStatus,
+  type TrialPhase,
+  type TrialIntervention,
+  type TrialEligibility,
+  type TrialLocation,
+  type TrialSponsor,
+  type TrialContact,
+  type TrialArm,
+  type TrialOutcome,
+  type BiomarkerRequirement,
+  type TrialSearchParams,
+  type TrialSearchResult,
+  type PatientProfile,
+  type TrialMatch
+} from './integrations/clinicalTrials/index.js';
+
+// ═══════════════════════════════════════════════════════════════════════════════
+// COMPLIANCE
+// ═══════════════════════════════════════════════════════════════════════════════
+
+export {
+  HIPAAComplianceService,
+  type AuditLogEntry,
+  type AuditEventType,
+  type AuditAction,
+  type PatientConsent,
+  type ConsentType,
+  type DataCategory,
+  type ConsentPurpose,
+  type AccessPolicy,
+  type AccessCondition,
+  type AccessDecision,
+  type EncryptionConfig,
+  type EncryptedData,
+  type DataMaskingConfig
+} from './compliance/index.js';
+
+// ═══════════════════════════════════════════════════════════════════════════════
+// MACHINE LEARNING
+// ═══════════════════════════════════════════════════════════════════════════════
+
+export {
+  OutcomePredictorService,
+  type PatientFeatures,
+  type TreatmentFeatures,
+  type ResponsePrediction,
+  type SurvivalPrediction,
+  type ToxicityPrediction,
+  type ResistancePrediction,
+  type TherapyRanking,
+  type MLModel,
+  type ModelRegistry
+} from './ml/index.js';
+
+// ═══════════════════════════════════════════════════════════════════════════════
+// SAFETY
+// ═══════════════════════════════════════════════════════════════════════════════
+
+export {
+  DrugSafetyService,
+  type Drug,
+  type CYP450Profile,
+  type DrugInteraction,
+  type Contraindication,
+  type DosingGuideline,
+  type AllergyCheck,
+  type SafetyAlert,
+  type PatientSafetyProfile
+} from './safety/index.js';
+
+// ═══════════════════════════════════════════════════════════════════════════════
+// VALIDATION
+// ═══════════════════════════════════════════════════════════════════════════════
+
+export {
+  RetrospectiveValidationService,
+  type ValidationPatient,
+  type SystemRecommendation,
+  type ValidationResult,
+  type CohortAnalysis
+} from './validation/index.js';
+
+// ═══════════════════════════════════════════════════════════════════════════════
+// CLINICIAN SUPPORT
+// ═══════════════════════════════════════════════════════════════════════════════
+
+export {
+  ClinicalDecisionSupportService,
+  type ClinicalRecommendation,
+  type ClinicianOverride,
+  type OverrideCategory,
+  type TumorBoardCase,
+  type AlertAcknowledgment
+} from './clinician/index.js';
+
+// ═══════════════════════════════════════════════════════════════════════════════
+// PATIENT PORTAL
+// ═══════════════════════════════════════════════════════════════════════════════
+
+export {
+  PatientPortalService,
+  type PatientAccount,
+  type PatientTreatmentSummary,
+  type SymptomReport,
+  type MedicationAdherenceLog,
+  type QualityOfLifeAssessment,
+  type PatientMessage,
+  type EducationalContent,
+  type AppointmentRequest
+} from './patient/index.js';
+
+// ═══════════════════════════════════════════════════════════════════════════════
+// QUICK START FACTORY
+// ═══════════════════════════════════════════════════════════════════════════════
+
+/**
+ * Quick start factory to create a fully configured oncology service
+ *
+ * @example
+ * ```typescript
+ * import { createOncologyPlatform } from 'agi-core-cure-cancer';
+ *
+ * const platform = await createOncologyPlatform({
+ *   ehr: {
+ *     enabled: true,
+ *     vendor: 'epic',
+ *     baseUrl: 'https://epic.hospital.org/fhir',
+ *     clientId: 'your-client-id'
+ *   },
+ *   genomics: {
+ *     enabled: true,
+ *     platforms: ['foundation', 'guardant']
+ *   }
+ * });
+ *
+ * const plan = await platform.generateComprehensivePlan(patient, 'DR001');
+ * ```
+ */
+export async function createOncologyPlatform(config?: Partial<RWConfig>): Promise<RWOService> {
+  const service = createRWOService(config);
+  await service.initialize();
+  return service;
+}