@erosolaraijs/cure 1.0.1 → 1.0.3

package/dist/compliance/index.d.ts.map

@@ -0,0 +1 @@
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package/dist/compliance/index.js

@@ -0,0 +1,5 @@
+/**
+ * HIPAA Compliance Module Exports
+ */
+export { HIPAAComplianceService } from './hipaa.js';
+//# sourceMappingURL=index.js.map

package/dist/compliance/index.js.map

@@ -0,0 +1 @@
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package/dist/index.d.ts

@@ -0,0 +1,65 @@
+/**
+ * AGI Core - Cure Cancer
+ *
+ * ██████╗██╗   ██╗██████╗ ███████╗     ██████╗ █████╗ ███╗   ██╗ ██████╗███████╗██████╗
+ * ██╔════╝██║   ██║██╔══██╗██╔════╝    ██╔════╝██╔══██╗████╗  ██║██╔════╝██╔════╝██╔══██╗
+ * ██║     ██║   ██║██████╔╝█████╗      ██║     ███████║██╔██╗ ██║██║     █████╗  ██████╔╝
+ * ██║     ██║   ██║██╔══██╗██╔══╝      ██║     ██╔══██║██║╚██╗██║██║     ██╔══╝  ██╔══██╗
+ * ╚██████╗╚██████╔╝██║  ██║███████╗    ╚██████╗██║  ██║██║ ╚████║╚██████╗███████╗██║  ██║
+ *  ╚═════╝ ╚═════╝ ╚═╝  ╚═╝╚══════╝     ╚═════╝╚═╝  ╚═╝╚═╝  ╚═══╝ ╚═════╝╚══════╝╚═╝  ╚═╝
+ *
+ * Comprehensive AI-powered precision oncology platform connecting:
+ * - Real genomic sequencing data (Foundation Medicine, Guardant, Tempus)
+ * - Hospital EHR systems (Epic, Cerner via HL7 FHIR)
+ * - Clinical trial registries (ClinicalTrials.gov)
+ * - HIPAA-compliant data handling
+ * - ML-powered outcome prediction
+ * - Drug safety and interaction checking
+ * - Clinician decision support
+ * - Patient portal interfaces
+ *
+ * @packageDocumentation
+ */
+export { CancerTreatmentCapabilityModule, type CancerTreatmentOperationType, type CancerPatient, type CancerTreatmentOperation, type CancerTreatmentResult, type TreatmentProtocol, type DrugTarget, type ImmunotherapyProtocol, type CombinationTherapy, type CancerCureResult } from './capabilities/cancerTreatmentCapability.js';
+export { RealWorldOncologyService, createRealWorldOncologyService, type RealWorldConfig, type RealWorldPatient, type ComprehensiveTreatmentPlan, type TreatmentOutcome } from './orchestrator/index.js';
+export { FHIRClient, EpicAdapter, CernerAdapter, FHIRPatientSummary, CancerDiagnosis, CancerBiomarkers, TreatmentHistory, type FHIRConfig, type FHIRResource, type FHIRPatient, type FHIRObservation, type FHIRCondition, type FHIRMedicationRequest, type FHIRProcedure, type FHIRDiagnosticReport } from './integrations/ehr/index.js';
+export { FoundationMedicineClient, GuardantHealthClient, TempusClient, UnifiedGenomicsService, type GenomicVariant, type CopyNumberAlteration, type GeneFusion, type GenomicReport, type TherapyMatch, type GenomicPlatformConfig } from './integrations/genomics/index.js';
+export { ClinicalTrialsGovClient, PatientTrialMatcher, type ClinicalTrial, type TrialLocation, type TrialEligibility, type PatientTrialMatch, type TrialSearchCriteria, type ClinicalTrialsConfig } from './integrations/clinicalTrials/index.js';
+export { HIPAAComplianceService, AuditLogger, ConsentManager, EncryptionService, AccessControlManager, DataMaskingService, type AuditLogEntry, type PatientConsent, type ConsentScope, type AccessPolicy, type AccessDecision, type HIPAAConfig } from './compliance/index.js';
+export { OutcomePredictionService, ResponsePredictor, SurvivalPredictor, ToxicityPredictor, ResistancePredictor, TherapyRanker, type PredictionInput, type ResponsePrediction, type SurvivalPrediction, type ToxicityPrediction, type ResistancePrediction, type TherapyRanking, type ModelMetadata, type MLConfig } from './ml/index.js';
+export { DrugSafetyService, DrugInteractionChecker, ContraindicationChecker, AllergyChecker, QTRiskAssessor, PharmacogenomicsChecker, BlackBoxWarningChecker, type DrugInteraction, type Contraindication, type AllergyAlert, type QTRiskAssessment, type PharmacogenomicAlert, type BlackBoxWarning, type SafetyCheckResult, type DrugSafetyConfig } from './safety/index.js';
+export { RetrospectiveValidator, CohortLoader, ConcordanceAnalyzer, PredictionAccuracyAnalyzer, SubgroupAnalyzer, ValidationReportGenerator, type ValidationCohort, type PatientOutcome, type ConcordanceResult, type PredictionAccuracy, type SubgroupAnalysis, type ValidationReport, type ValidationConfig } from './validation/index.js';
+export { ClinicalDecisionSupport, RecommendationEngine, OverrideManager, TumorBoardManager, RiskBenefitAnalyzer, ExplanationGenerator, type ClinicalRecommendation, type OverrideRecord, type TumorBoardCase, type RiskBenefitAnalysis, type RecommendationExplanation, type DecisionSupportConfig } from './clinician/index.js';
+export { PatientPortalService, PatientAccountManager, TreatmentSummaryService, SymptomTracker, MedicationAdherenceTracker, QualityOfLifeAssessment, SecureMessaging, EducationalContentService, AppointmentRequestService, PatientDashboard, type PatientAccount, type TreatmentSummary, type SymptomEntry, type AdherenceRecord, type QoLAssessment, type SecureMessage, type EducationalContent, type AppointmentRequest, type PatientDashboardData, type PatientPortalConfig } from './patient/index.js';
+/**
+ * Quick start factory to create a fully configured oncology service
+ *
+ * @example
+ * ```typescript
+ * import { createOncologyPlatform } from 'agi-core-cure-cancer';
+ *
+ * const platform = await createOncologyPlatform({
+ *   ehr: {
+ *     enabled: true,
+ *     vendor: 'epic',
+ *     baseUrl: 'https://epic.hospital.org/fhir',
+ *     clientId: 'your-client-id'
+ *   },
+ *   genomics: {
+ *     enabled: true,
+ *     platforms: ['foundation', 'guardant']
+ *   }
+ * });
+ *
+ * const plan = await platform.generateComprehensivePlan(patient, 'DR001');
+ * ```
+ */
+export declare function createOncologyPlatform(config?: Partial<import('./orchestrator/index.js').RealWorldConfig>): Promise<RealWorldOncologyService>;
+declare const _default: {
+    createOncologyPlatform: typeof createOncologyPlatform;
+    createRealWorldOncologyService: any;
+    CancerTreatmentCapabilityModule: any;
+    RealWorldOncologyService: any;
+};
+export default _default;
+//# sourceMappingURL=index.d.ts.map

package/dist/index.d.ts.map

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package/dist/index.js

@@ -0,0 +1,102 @@
+/**
+ * AGI Core - Cure Cancer
+ *
+ * ██████╗██╗   ██╗██████╗ ███████╗     ██████╗ █████╗ ███╗   ██╗ ██████╗███████╗██████╗
+ * ██╔════╝██║   ██║██╔══██╗██╔════╝    ██╔════╝██╔══██╗████╗  ██║██╔════╝██╔════╝██╔══██╗
+ * ██║     ██║   ██║██████╔╝█████╗      ██║     ███████║██╔██╗ ██║██║     █████╗  ██████╔╝
+ * ██║     ██║   ██║██╔══██╗██╔══╝      ██║     ██╔══██║██║╚██╗██║██║     ██╔══╝  ██╔══██╗
+ * ╚██████╗╚██████╔╝██║  ██║███████╗    ╚██████╗██║  ██║██║ ╚████║╚██████╗███████╗██║  ██║
+ *  ╚═════╝ ╚═════╝ ╚═╝  ╚═╝╚══════╝     ╚═════╝╚═╝  ╚═╝╚═╝  ╚═══╝ ╚═════╝╚══════╝╚═╝  ╚═╝
+ *
+ * Comprehensive AI-powered precision oncology platform connecting:
+ * - Real genomic sequencing data (Foundation Medicine, Guardant, Tempus)
+ * - Hospital EHR systems (Epic, Cerner via HL7 FHIR)
+ * - Clinical trial registries (ClinicalTrials.gov)
+ * - HIPAA-compliant data handling
+ * - ML-powered outcome prediction
+ * - Drug safety and interaction checking
+ * - Clinician decision support
+ * - Patient portal interfaces
+ *
+ * @packageDocumentation
+ */
+// ═══════════════════════════════════════════════════════════════════════════════
+// CORE CAPABILITIES
+// ═══════════════════════════════════════════════════════════════════════════════
+export { CancerTreatmentCapabilityModule } from './capabilities/cancerTreatmentCapability.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// REAL-WORLD ORCHESTRATION
+// ═══════════════════════════════════════════════════════════════════════════════
+export { RealWorldOncologyService, createRealWorldOncologyService } from './orchestrator/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// INTEGRATIONS
+// ═══════════════════════════════════════════════════════════════════════════════
+// EHR Integration (HL7 FHIR)
+export { FHIRClient, EpicAdapter, CernerAdapter, FHIRPatientSummary } from './integrations/ehr/index.js';
+// Genomic Platforms
+export { FoundationMedicineClient, GuardantHealthClient, TempusClient, UnifiedGenomicsService } from './integrations/genomics/index.js';
+// Clinical Trials
+export { ClinicalTrialsGovClient, PatientTrialMatcher } from './integrations/clinicalTrials/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// COMPLIANCE
+// ═══════════════════════════════════════════════════════════════════════════════
+export { HIPAAComplianceService, AuditLogger, ConsentManager, EncryptionService, AccessControlManager, DataMaskingService } from './compliance/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// MACHINE LEARNING
+// ═══════════════════════════════════════════════════════════════════════════════
+export { OutcomePredictionService, ResponsePredictor, SurvivalPredictor, ToxicityPredictor, ResistancePredictor, TherapyRanker } from './ml/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// SAFETY
+// ═══════════════════════════════════════════════════════════════════════════════
+export { DrugSafetyService, DrugInteractionChecker, ContraindicationChecker, AllergyChecker, QTRiskAssessor, PharmacogenomicsChecker, BlackBoxWarningChecker } from './safety/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// VALIDATION
+// ═══════════════════════════════════════════════════════════════════════════════
+export { RetrospectiveValidator, CohortLoader, ConcordanceAnalyzer, PredictionAccuracyAnalyzer, SubgroupAnalyzer, ValidationReportGenerator } from './validation/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// CLINICIAN SUPPORT
+// ═══════════════════════════════════════════════════════════════════════════════
+export { ClinicalDecisionSupport, RecommendationEngine, OverrideManager, TumorBoardManager, RiskBenefitAnalyzer, ExplanationGenerator } from './clinician/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// PATIENT PORTAL
+// ═══════════════════════════════════════════════════════════════════════════════
+export { PatientPortalService, PatientAccountManager, TreatmentSummaryService, SymptomTracker, MedicationAdherenceTracker, QualityOfLifeAssessment, SecureMessaging, EducationalContentService, AppointmentRequestService, PatientDashboard } from './patient/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// QUICK START FACTORY
+// ═══════════════════════════════════════════════════════════════════════════════
+/**
+ * Quick start factory to create a fully configured oncology service
+ *
+ * @example
+ * ```typescript
+ * import { createOncologyPlatform } from 'agi-core-cure-cancer';
+ *
+ * const platform = await createOncologyPlatform({
+ *   ehr: {
+ *     enabled: true,
+ *     vendor: 'epic',
+ *     baseUrl: 'https://epic.hospital.org/fhir',
+ *     clientId: 'your-client-id'
+ *   },
+ *   genomics: {
+ *     enabled: true,
+ *     platforms: ['foundation', 'guardant']
+ *   }
+ * });
+ *
+ * const plan = await platform.generateComprehensivePlan(patient, 'DR001');
+ * ```
+ */
+export async function createOncologyPlatform(config) {
+    const service = createRealWorldOncologyService(config);
+    await service.initialize();
+    return service;
+}
+// Default export
+export default {
+    createOncologyPlatform,
+    createRealWorldOncologyService,
+    CancerTreatmentCapabilityModule,
+    RealWorldOncologyService
+};
+//# sourceMappingURL=index.js.map

package/dist/index.js.map

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package/dist/integrations/clinicalTrials/index.d.ts

@@ -0,0 +1,5 @@
+/**
+ * Clinical Trials Integration Module Exports
+ */
+export { ClinicalTrialsGovClient, type ClinicalTrial, type TrialStatus, type TrialPhase, type TrialIntervention, type TrialEligibility, type TrialLocation, type TrialSponsor, type TrialContact, type TrialArm, type TrialOutcome, type BiomarkerRequirement, type TrialSearchParams, type TrialSearchResult, type PatientProfile, type TrialMatch } from './clinicalTrialsGov.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/integrations/clinicalTrials/index.d.ts.map

@@ -0,0 +1 @@
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package/dist/integrations/clinicalTrials/index.js

@@ -0,0 +1,5 @@
+/**
+ * Clinical Trials Integration Module Exports
+ */
+export { ClinicalTrialsGovClient } from './clinicalTrialsGov.js';
+//# sourceMappingURL=index.js.map

package/dist/integrations/clinicalTrials/index.js.map

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package/dist/integrations/ehr/index.d.ts

@@ -0,0 +1,5 @@
+/**
+ * EHR Integration Module Exports
+ */
+export { FHIRClient, EpicFHIRClient, CernerFHIRClient, createFHIRClient, type FHIRConfig, type FHIRPatient, type FHIRIdentifier, type FHIRHumanName, type FHIRAddress, type FHIRContactPoint, type FHIRCodeableConcept, type FHIRCoding, type FHIRExtension, type FHIRCondition, type FHIRObservation, type FHIRQuantity, type FHIRReference, type FHIRMedicationRequest, type FHIRDosage, type FHIRDiagnosticReport, type FHIRProcedure, type FHIRBundle, type FHIRResource, type CancerDiagnosis, type CancerBiomarkers, type TreatmentHistory, type AuditEvent } from './fhir.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/integrations/ehr/index.d.ts.map

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package/dist/integrations/ehr/index.js

@@ -0,0 +1,5 @@
+/**
+ * EHR Integration Module Exports
+ */
+export { FHIRClient, EpicFHIRClient, CernerFHIRClient, createFHIRClient } from './fhir.js';
+//# sourceMappingURL=index.js.map

package/dist/integrations/ehr/index.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"index.js","sourceRoot":"","sources":["../../../src/integrations/ehr/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,UAAU,EACV,cAAc,EACd,gBAAgB,EAChB,gBAAgB,EAwBjB,MAAM,WAAW,CAAC"}

package/dist/integrations/genomics/index.d.ts

@@ -0,0 +1,5 @@
+/**
+ * Genomic Platform Integration Module Exports
+ */
+export { FoundationMedicineClient, GuardantHealthClient, TempusClient, UnifiedGenomicsService, createGenomicClient, type GenomicTestOrder, type GenomicTestResult, type GenomicVariant, type CopyNumberAlteration, type GeneFusion, type GenomicBiomarker, type MSIResult, type TMBResult, type HRDResult, type LOHResult, type TherapyMatch, type ClinicalTrialMatch, type GenomicPlatformConfig } from './genomicPlatforms.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/integrations/genomics/index.d.ts.map

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+{"version":3,"file":"index.d.ts","sourceRoot":"","sources":["../../../src/integrations/genomics/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,wBAAwB,EACxB,oBAAoB,EACpB,YAAY,EACZ,sBAAsB,EACtB,mBAAmB,EACnB,KAAK,gBAAgB,EACrB,KAAK,iBAAiB,EACtB,KAAK,cAAc,EACnB,KAAK,oBAAoB,EACzB,KAAK,UAAU,EACf,KAAK,gBAAgB,EACrB,KAAK,SAAS,EACd,KAAK,SAAS,EACd,KAAK,SAAS,EACd,KAAK,SAAS,EACd,KAAK,YAAY,EACjB,KAAK,kBAAkB,EACvB,KAAK,qBAAqB,EAC3B,MAAM,uBAAuB,CAAC"}

package/dist/integrations/genomics/index.js

@@ -0,0 +1,5 @@
+/**
+ * Genomic Platform Integration Module Exports
+ */
+export { FoundationMedicineClient, GuardantHealthClient, TempusClient, UnifiedGenomicsService, createGenomicClient } from './genomicPlatforms.js';
+//# sourceMappingURL=index.js.map

package/dist/integrations/genomics/index.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"index.js","sourceRoot":"","sources":["../../../src/integrations/genomics/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,wBAAwB,EACxB,oBAAoB,EACpB,YAAY,EACZ,sBAAsB,EACtB,mBAAmB,EAcpB,MAAM,uBAAuB,CAAC"}

package/dist/ml/index.d.ts

@@ -0,0 +1,5 @@
+/**
+ * Machine Learning Module Exports
+ */
+export { OutcomePredictorService, type PatientFeatures, type TreatmentFeatures, type ResponsePrediction, type SurvivalPrediction, type ToxicityPrediction, type ResistancePrediction, type TherapyRanking, type MLModel, type ModelRegistry } from './outcomePredictor.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/ml/index.d.ts.map

@@ -0,0 +1 @@
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package/dist/ml/index.js

@@ -0,0 +1,5 @@
+/**
+ * Machine Learning Module Exports
+ */
+export { OutcomePredictorService } from './outcomePredictor.js';
+//# sourceMappingURL=index.js.map

package/dist/ml/index.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"index.js","sourceRoot":"","sources":["../../src/ml/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,uBAAuB,EAUxB,MAAM,uBAAuB,CAAC"}

package/dist/ml/outcomePredictor.d.ts

@@ -0,0 +1,297 @@
+/**
+ * Machine Learning Outcome Prediction Infrastructure
+ *
+ * Provides ML-based prediction models for:
+ * - Treatment response prediction
+ * - Survival probability estimation
+ * - Toxicity risk assessment
+ * - Resistance prediction
+ * - Optimal therapy selection
+ *
+ * This module provides the infrastructure for training and deploying
+ * ML models. In production, models would be trained on real patient cohorts
+ * with proper validation and FDA clearance.
+ */
+import { EventEmitter } from 'events';
+export interface PatientFeatures {
+    age: number;
+    gender: 'male' | 'female';
+    ethnicity?: string;
+    bmi?: number;
+    cancerType: string;
+    histology?: string;
+    stage: 'I' | 'II' | 'III' | 'IV' | 'IA' | 'IB' | 'IIA' | 'IIB' | 'IIIA' | 'IIIB' | 'IIIC' | 'IVA' | 'IVB';
+    grade?: 1 | 2 | 3;
+    tumorSize?: number;
+    lymphNodeInvolvement?: number;
+    metastaticSites?: string[];
+    ecogStatus: 0 | 1 | 2 | 3 | 4;
+    genomicAlterations: {
+        gene: string;
+        alteration: string;
+        type: 'mutation' | 'amplification' | 'deletion' | 'fusion';
+        vaf?: number;
+    }[];
+    pdl1Score?: number;
+    pdl1ScoreType?: 'TPS' | 'CPS' | 'IC';
+    msiStatus?: 'MSI-H' | 'MSI-L' | 'MSS';
+    tmbValue?: number;
+    tmbStatus?: 'high' | 'low';
+    hrdScore?: number;
+    hrdStatus?: 'positive' | 'negative';
+    brcaStatus?: 'BRCA1' | 'BRCA2' | 'wild-type';
+    ldh?: number;
+    albumin?: number;
+    hemoglobin?: number;
+    neutrophils?: number;
+    lymphocytes?: number;
+    platelets?: number;
+    creatinine?: number;
+    bilirubin?: number;
+    alkalinePhosphatase?: number;
+    priorLines?: number;
+    priorTherapies?: string[];
+    priorResponse?: 'CR' | 'PR' | 'SD' | 'PD';
+    treatmentFreeInterval?: number;
+    comorbidityIndex?: number;
+    organFunction?: {
+        cardiac?: 'normal' | 'impaired';
+        hepatic?: 'normal' | 'impaired';
+        renal?: 'normal' | 'impaired';
+        pulmonary?: 'normal' | 'impaired';
+    };
+}
+export interface TreatmentFeatures {
+    regimen: string;
+    drugs: string[];
+    treatmentType: 'chemotherapy' | 'immunotherapy' | 'targeted' | 'combination' | 'radiation' | 'surgery' | 'car-t';
+    setting: 'neoadjuvant' | 'adjuvant' | 'first-line' | 'second-line' | 'third-line-plus' | 'maintenance';
+    dosing?: 'standard' | 'reduced' | 'dose-dense';
+    schedule?: string;
+}
+export interface ResponsePrediction {
+    predictedResponse: 'CR' | 'PR' | 'SD' | 'PD';
+    probabilities: {
+        completeResponse: number;
+        partialResponse: number;
+        stableDisease: number;
+        progressiveDisease: number;
+    };
+    confidence: number;
+    objectiveResponseRate: number;
+    diseaseControlRate: number;
+    timeToResponse?: {
+        median: number;
+        range: [number, number];
+    };
+}
+export interface SurvivalPrediction {
+    pfs: {
+        median: number;
+        sixMonth: number;
+        twelveMonth: number;
+        twentyFourMonth: number;
+        confidence: number;
+        hazardRatio?: number;
+    };
+    os: {
+        median: number;
+        twelveMonth: number;
+        twentyFourMonth: number;
+        fiveYear: number;
+        confidence: number;
+        hazardRatio?: number;
+    };
+    riskGroup: 'low' | 'intermediate-low' | 'intermediate-high' | 'high';
+    riskScore: number;
+}
+export interface ToxicityPrediction {
+    overallRisk: 'low' | 'moderate' | 'high';
+    grade3PlusRisk: number;
+    specificRisks: {
+        toxicity: string;
+        grade: 1 | 2 | 3 | 4 | 5;
+        probability: number;
+        timeToOnset?: {
+            median: number;
+            unit: 'days' | 'weeks' | 'cycles';
+        };
+        reversible: boolean;
+        management?: string;
+    }[];
+    iraeRisk?: {
+        any: number;
+        grade3Plus: number;
+        specificOrgans: {
+            organ: string;
+            risk: number;
+        }[];
+    };
+    doseModification?: {
+        recommended: boolean;
+        reduction: number;
+        reason: string;
+    };
+}
+export interface ResistancePrediction {
+    intrinsicResistanceRisk: number;
+    acquiredResistanceRisk: number;
+    predictedMechanisms: {
+        mechanism: string;
+        probability: number;
+        monitoringBiomarker?: string;
+    }[];
+    timeToResistance?: {
+        median: number;
+        range: [number, number];
+    };
+    nextLineOptions: {
+        therapy: string;
+        rationale: string;
+        expectedBenefit: number;
+    }[];
+}
+export interface TherapyRanking {
+    therapies: {
+        regimen: string;
+        drugs: string[];
+        rank: number;
+        predictions: {
+            responseRate: number;
+            pfsSurvival: number;
+            osSurvival: number;
+            toxicityRisk: number;
+            qualityOfLifeScore: number;
+        };
+        overallScore: number;
+        confidence: number;
+        matchingBiomarkers: string[];
+        fdaApproved: boolean;
+        nccnRecommended: boolean;
+        considerations: string[];
+        contraindications?: string[];
+    }[];
+    bestChoice: {
+        regimen: string;
+        rationale: string[];
+    };
+}
+export interface MLModel {
+    id: string;
+    name: string;
+    version: string;
+    type: 'classification' | 'regression' | 'survival' | 'ranking';
+    target: 'response' | 'pfs' | 'os' | 'toxicity' | 'resistance';
+    cancerTypes: string[];
+    performance: {
+        auc?: number;
+        accuracy?: number;
+        sensitivity?: number;
+        specificity?: number;
+        cIndex?: number;
+        calibration?: number;
+        brier?: number;
+    };
+    validation: {
+        method: 'cross-validation' | 'temporal' | 'external' | 'prospective';
+        cohortSize: number;
+        testSetSize: number;
+        validationDate: Date;
+    };
+    features: string[];
+    importantFeatures: {
+        feature: string;
+        importance: number;
+    }[];
+    status: 'development' | 'validation' | 'clinical-use' | 'deprecated';
+    regulatoryStatus?: 'not-submitted' | 'pending' | 'cleared' | '510k' | 'de-novo';
+}
+export interface ModelRegistry {
+    models: MLModel[];
+    getModel(id: string): MLModel | undefined;
+    getBestModel(target: MLModel['target'], cancerType: string): MLModel | undefined;
+    registerModel(model: MLModel): void;
+}
+export declare class OutcomePredictorService extends EventEmitter {
+    private modelRegistry;
+    private featureEncoders;
+    private predictionCache;
+    private cacheDuration;
+    constructor();
+    /**
+     * Predict treatment response
+     */
+    predictResponse(patient: PatientFeatures, treatment: TreatmentFeatures): Promise<ResponsePrediction>;
+    /**
+     * Predict survival outcomes
+     */
+    predictSurvival(patient: PatientFeatures, treatment: TreatmentFeatures): Promise<SurvivalPrediction>;
+    /**
+     * Predict toxicity risk
+     */
+    predictToxicity(patient: PatientFeatures, treatment: TreatmentFeatures): Promise<ToxicityPrediction>;
+    /**
+     * Predict resistance development
+     */
+    predictResistance(patient: PatientFeatures, treatment: TreatmentFeatures): Promise<ResistancePrediction>;
+    /**
+     * Rank treatment options
+     */
+    rankTherapies(patient: PatientFeatures, treatmentOptions: TreatmentFeatures[], preferences?: {
+        prioritizeEfficacy?: boolean;
+        prioritizeToxicity?: boolean;
+        prioritizeQoL?: boolean;
+    }): Promise<TherapyRanking>;
+    /**
+     * Get comprehensive prediction report
+     */
+    getComprehensivePrediction(patient: PatientFeatures, treatment: TreatmentFeatures): Promise<{
+        response: ResponsePrediction;
+        survival: SurvivalPrediction;
+        toxicity: ToxicityPrediction;
+        resistance: ResistancePrediction;
+        overallAssessment: {
+            recommendation: 'strongly-recommended' | 'recommended' | 'consider' | 'caution' | 'not-recommended';
+            rationale: string[];
+            caveats: string[];
+            alternativeOptions: string[];
+        };
+    }>;
+    private computeResponsePrediction;
+    private computeSurvivalPrediction;
+    private computeToxicityPrediction;
+    private computeResistancePrediction;
+    private initializeDefaultModels;
+    private initializeFeatureEncoders;
+    private encodeFeatures;
+    private getBestModel;
+    private hasBiomarkerMatch;
+    private hasImmunotherapyDrug;
+    private getDrugToxicityProfiles;
+    private getResistanceMechanisms;
+    private getNextLineOptions;
+    private estimateQoLScore;
+    private getMatchingBiomarkers;
+    private isBiomarkerRelevant;
+    private checkFDAApproval;
+    private checkNCCNRecommendation;
+    private getConsiderations;
+    private generateOverallAssessment;
+    private getCacheKey;
+    private getFromCache;
+    private setCache;
+    /**
+     * Register a new model
+     */
+    registerModel(model: MLModel): void;
+    /**
+     * Get model performance metrics
+     */
+    getModelMetrics(modelId: string): MLModel['performance'] | undefined;
+    /**
+     * List all available models
+     */
+    listModels(): MLModel[];
+}
+export default OutcomePredictorService;
+//# sourceMappingURL=outcomePredictor.d.ts.map

package/dist/ml/outcomePredictor.d.ts.map

@@ -0,0 +1 @@
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