@erosolaraijs/cure 1.0.1 → 1.0.3

package/dist/safety/drugInteractions.js.map

@@ -0,0 +1 @@
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package/dist/safety/index.d.ts

@@ -0,0 +1,5 @@
+/**
+ * Drug Safety Module Exports
+ */
+export { DrugSafetyService, type Drug, type CYP450Profile, type DrugInteraction, type Contraindication, type DosingGuideline, type AllergyCheck, type SafetyAlert, type PatientSafetyProfile } from './drugInteractions.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/safety/index.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"index.d.ts","sourceRoot":"","sources":["../../src/safety/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,iBAAiB,EACjB,KAAK,IAAI,EACT,KAAK,aAAa,EAClB,KAAK,eAAe,EACpB,KAAK,gBAAgB,EACrB,KAAK,eAAe,EACpB,KAAK,YAAY,EACjB,KAAK,WAAW,EAChB,KAAK,oBAAoB,EAC1B,MAAM,uBAAuB,CAAC"}

package/dist/safety/index.js

@@ -0,0 +1,5 @@
+/**
+ * Drug Safety Module Exports
+ */
+export { DrugSafetyService } from './drugInteractions.js';
+//# sourceMappingURL=index.js.map

package/dist/safety/index.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"index.js","sourceRoot":"","sources":["../../src/safety/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,iBAAiB,EASlB,MAAM,uBAAuB,CAAC"}

package/dist/validation/index.d.ts

@@ -0,0 +1,5 @@
+/**
+ * Validation Framework Module Exports
+ */
+export { RetrospectiveValidationService, type ValidationPatient, type SystemRecommendation, type ValidationResult, type CohortAnalysis } from './retrospectiveValidator.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/validation/index.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"index.d.ts","sourceRoot":"","sources":["../../src/validation/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,8BAA8B,EAC9B,KAAK,iBAAiB,EACtB,KAAK,oBAAoB,EACzB,KAAK,gBAAgB,EACrB,KAAK,cAAc,EACpB,MAAM,6BAA6B,CAAC"}

package/dist/validation/index.js

@@ -0,0 +1,5 @@
+/**
+ * Validation Framework Module Exports
+ */
+export { RetrospectiveValidationService } from './retrospectiveValidator.js';
+//# sourceMappingURL=index.js.map

package/dist/validation/index.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"index.js","sourceRoot":"","sources":["../../src/validation/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,8BAA8B,EAK/B,MAAM,6BAA6B,CAAC"}

package/dist/validation/retrospectiveValidator.d.ts

@@ -0,0 +1,246 @@
+/**
+ * Retrospective Validation Framework
+ *
+ * Provides tools for validating the treatment recommendation system against
+ * real patient outcomes. Essential for:
+ * - Model performance assessment
+ * - Calibration checking
+ * - Concordance analysis with actual treatments
+ * - Outcome correlation studies
+ * - Continuous quality improvement
+ *
+ * IMPORTANT: All patient data used for validation must be properly de-identified
+ * or used with appropriate IRB approval and patient consent.
+ */
+import { EventEmitter } from 'events';
+export interface ValidationPatient {
+    id: string;
+    demographics: {
+        ageAtDiagnosis: number;
+        gender: 'male' | 'female';
+        ethnicity?: string;
+    };
+    diagnosis: {
+        cancerType: string;
+        histology?: string;
+        stage: string;
+        diagnosisDate: Date;
+        biomarkers?: {
+            name: string;
+            value: string | number;
+            status?: string;
+        }[];
+        genomicAlterations?: {
+            gene: string;
+            alteration: string;
+        }[];
+        msiStatus?: 'MSI-H' | 'MSI-L' | 'MSS';
+        tmbValue?: number;
+        pdl1Score?: number;
+        hrdStatus?: boolean;
+    };
+    treatment: {
+        regimen: string;
+        drugs: string[];
+        setting: string;
+        startDate: Date;
+        endDate?: Date;
+        cycles?: number;
+        doseModifications?: boolean;
+    };
+    outcomes: {
+        bestResponse?: 'CR' | 'PR' | 'SD' | 'PD' | 'NE';
+        responseDate?: Date;
+        progressionDate?: Date;
+        deathDate?: Date;
+        lastFollowUpDate: Date;
+        causeOfDeath?: 'disease' | 'treatment' | 'other' | 'unknown';
+        toxicities?: {
+            name: string;
+            grade: number;
+            date?: Date;
+        }[];
+    };
+    ecogAtBaseline?: number;
+    priorLines?: number;
+}
+export interface SystemRecommendation {
+    patientId: string;
+    recommendedRegimen: string;
+    recommendedDrugs: string[];
+    predictions: {
+        responseRate: number;
+        pfsMonths: number;
+        osMonths: number;
+        toxicityRisk: number;
+    };
+    matchingBiomarkers: string[];
+    confidenceScore: number;
+    timestamp: Date;
+}
+export interface ValidationResult {
+    patientId: string;
+    concordance: {
+        regimenMatch: boolean;
+        partialMatch: boolean;
+        matchedDrugs: string[];
+    };
+    outcomeComparison: {
+        predictedResponse: number;
+        actualResponse?: 'CR' | 'PR' | 'SD' | 'PD' | 'NE';
+        responseCorrect?: boolean;
+        predictedPFS: number;
+        actualPFS?: number;
+        pfsDifference?: number;
+        predictedOS: number;
+        actualOS?: number;
+        osDifference?: number;
+        predictedToxicityRisk: number;
+        actualGrade3PlusToxicity: boolean;
+    };
+    clinicalBenefit: {
+        objectiveResponse: boolean;
+        diseaseControl: boolean;
+        durableBenefit: boolean;
+    };
+}
+export interface CohortAnalysis {
+    cohortId: string;
+    description: string;
+    patientCount: number;
+    dateRange: {
+        start: Date;
+        end: Date;
+    };
+    demographics: {
+        medianAge: number;
+        ageRange: [number, number];
+        genderDistribution: {
+            male: number;
+            female: number;
+        };
+        stageDistribution: Record<string, number>;
+    };
+    concordance: {
+        fullConcordance: number;
+        partialConcordance: number;
+        noConcordance: number;
+        concordanceByBiomarker: Record<string, number>;
+    };
+    predictionAccuracy: {
+        responseAccuracy: number;
+        responseSensitivity: number;
+        responseSpecificity: number;
+        responseAUC?: number;
+        pfsCIndex: number;
+        pfsCalibration: number;
+        osCIndex: number;
+        osCalibration: number;
+        toxicityAccuracy: number;
+        toxicityAUC?: number;
+    };
+    clinicalImpact: {
+        objectiveResponseRate: number;
+        diseaseControlRate: number;
+        medianPFS: number;
+        medianOS: number;
+        concordantVsDiscordant: {
+            concordantORR: number;
+            discordantORR: number;
+            concordantMedianPFS: number;
+            discordantMedianPFS: number;
+            pValue?: number;
+        };
+    };
+    subgroupAnalyses: {
+        subgroup: string;
+        patientCount: number;
+        concordance: number;
+        responseAccuracy: number;
+        medianPFS: number;
+    }[];
+}
+export declare class RetrospectiveValidationService extends EventEmitter {
+    private validationCohorts;
+    private systemRecommendations;
+    private validationResults;
+    constructor();
+    /**
+     * Load a validation cohort
+     */
+    loadCohort(cohortId: string, patients: ValidationPatient[]): void;
+    /**
+     * Load system recommendations for comparison
+     */
+    loadRecommendations(recommendations: SystemRecommendation[]): void;
+    /**
+     * Run validation for a cohort
+     */
+    runValidation(cohortId: string): Promise<CohortAnalysis>;
+    /**
+     * Validate a single patient
+     */
+    private validatePatient;
+    /**
+     * Assess concordance between recommendation and actual treatment
+     */
+    private assessConcordance;
+    /**
+     * Check if two drug names refer to the same drug
+     */
+    private drugsMatch;
+    /**
+     * Calculate PFS in months
+     */
+    private calculatePFS;
+    /**
+     * Calculate OS in months
+     */
+    private calculateOS;
+    /**
+     * Assess if response prediction was accurate
+     */
+    private assessResponseAccuracy;
+    /**
+     * Compute cohort-level analysis
+     */
+    private computeCohortAnalysis;
+    /**
+     * Calculate concordance index (C-index)
+     */
+    private calculateCIndex;
+    /**
+     * Calculate calibration score (0-1, higher is better)
+     */
+    private calculateCalibration;
+    /**
+     * Calculate median of an array
+     */
+    private calculateMedian;
+    /**
+     * Calculate concordance by biomarker subgroup
+     */
+    private calculateConcordanceByBiomarker;
+    /**
+     * Perform subgroup analyses
+     */
+    private performSubgroupAnalyses;
+    /**
+     * Calculate response accuracy for a subgroup
+     */
+    private calculateSubgroupResponseAccuracy;
+    /**
+     * Validate and de-identify patient data
+     */
+    private validateAndDeidentify;
+    /**
+     * Generate validation report
+     */
+    generateReport(analysis: CohortAnalysis): string;
+    /**
+     * Export validation results
+     */
+    exportResults(cohortId: string, format: 'json' | 'csv'): string;
+}
+export default RetrospectiveValidationService;
+//# sourceMappingURL=retrospectiveValidator.d.ts.map

package/dist/validation/retrospectiveValidator.d.ts.map

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