@erosolaraijs/cure 1.0.1 → 1.0.2

package/dist/compliance/index.d.ts.map

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package/dist/compliance/index.js

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+/**
+ * HIPAA Compliance Module Exports
+ */
+export { HIPAAComplianceService, AuditLogger, ConsentManager, EncryptionService, AccessControlManager, DataMaskingService } from './hipaa.js';
+//# sourceMappingURL=index.js.map

package/dist/compliance/index.js.map

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package/dist/integrations/clinicalTrials/index.d.ts

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+/**
+ * Clinical Trials Integration Module Exports
+ */
+export { ClinicalTrialsGovClient, PatientTrialMatcher, type ClinicalTrial, type TrialLocation, type TrialEligibility, type PatientTrialMatch, type TrialSearchCriteria, type ClinicalTrialsConfig } from './clinicalTrialsGov.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/integrations/clinicalTrials/index.d.ts.map

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package/dist/integrations/clinicalTrials/index.js

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+/**
+ * Clinical Trials Integration Module Exports
+ */
+export { ClinicalTrialsGovClient, PatientTrialMatcher } from './clinicalTrialsGov.js';
+//# sourceMappingURL=index.js.map

package/dist/integrations/clinicalTrials/index.js.map

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package/dist/integrations/ehr/index.d.ts

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+/**
+ * EHR Integration Module Exports
+ */
+export { FHIRClient, EpicAdapter, CernerAdapter, FHIRPatientSummary, CancerDiagnosis, CancerBiomarkers, TreatmentHistory, type FHIRConfig, type FHIRResource, type FHIRPatient, type FHIRObservation, type FHIRCondition, type FHIRMedicationRequest, type FHIRProcedure, type FHIRDiagnosticReport } from './fhir.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/integrations/ehr/index.d.ts.map

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package/dist/integrations/ehr/index.js

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+/**
+ * EHR Integration Module Exports
+ */
+export { FHIRClient, EpicAdapter, CernerAdapter, FHIRPatientSummary } from './fhir.js';
+//# sourceMappingURL=index.js.map

package/dist/integrations/ehr/index.js.map

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+{"version":3,"file":"index.js","sourceRoot":"","sources":["../../../src/integrations/ehr/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,UAAU,EACV,WAAW,EACX,aAAa,EACb,kBAAkB,EAYnB,MAAM,WAAW,CAAC"}

package/dist/integrations/genomics/index.d.ts

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+/**
+ * Genomic Platform Integration Module Exports
+ */
+export { FoundationMedicineClient, GuardantHealthClient, TempusClient, UnifiedGenomicsService, type GenomicVariant, type CopyNumberAlteration, type GeneFusion, type GenomicReport, type TherapyMatch, type GenomicPlatformConfig } from './genomicPlatforms.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/integrations/genomics/index.d.ts.map

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package/dist/integrations/genomics/index.js

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+/**
+ * Genomic Platform Integration Module Exports
+ */
+export { FoundationMedicineClient, GuardantHealthClient, TempusClient, UnifiedGenomicsService } from './genomicPlatforms.js';
+//# sourceMappingURL=index.js.map

package/dist/integrations/genomics/index.js.map

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package/dist/integrations/index.d.ts

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+/**
+ * Integrations Module - All External System Connections
+ */
+export * from './ehr/index.js';
+export * from './genomics/index.js';
+export * from './clinicalTrials/index.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/integrations/index.d.ts.map

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package/dist/integrations/index.js

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+/**
+ * Integrations Module - All External System Connections
+ */
+// EHR Integrations
+export * from './ehr/index.js';
+// Genomic Platform Integrations
+export * from './genomics/index.js';
+// Clinical Trials Integration
+export * from './clinicalTrials/index.js';
+//# sourceMappingURL=index.js.map

package/dist/integrations/index.js.map

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package/dist/ml/index.d.ts

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+/**
+ * Machine Learning Module Exports
+ */
+export { OutcomePredictionService, ResponsePredictor, SurvivalPredictor, ToxicityPredictor, ResistancePredictor, TherapyRanker, type PredictionInput, type ResponsePrediction, type SurvivalPrediction, type ToxicityPrediction, type ResistancePrediction, type TherapyRanking, type ModelMetadata, type MLConfig } from './outcomePredictor.js';
+//# sourceMappingURL=index.d.ts.map

package/dist/ml/index.d.ts.map

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package/dist/ml/index.js

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+/**
+ * Machine Learning Module Exports
+ */
+export { OutcomePredictionService, ResponsePredictor, SurvivalPredictor, ToxicityPredictor, ResistancePredictor, TherapyRanker } from './outcomePredictor.js';
+//# sourceMappingURL=index.js.map

package/dist/ml/index.js.map

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package/dist/ml/outcomePredictor.d.ts

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+/**
+ * Machine Learning Outcome Prediction Infrastructure
+ *
+ * Provides ML-based prediction models for:
+ * - Treatment response prediction
+ * - Survival probability estimation
+ * - Toxicity risk assessment
+ * - Resistance prediction
+ * - Optimal therapy selection
+ *
+ * This module provides the infrastructure for training and deploying
+ * ML models. In production, models would be trained on real patient cohorts
+ * with proper validation and FDA clearance.
+ */
+import { EventEmitter } from 'events';
+export interface PatientFeatures {
+    age: number;
+    gender: 'male' | 'female';
+    ethnicity?: string;
+    bmi?: number;
+    cancerType: string;
+    histology?: string;
+    stage: 'I' | 'II' | 'III' | 'IV' | 'IA' | 'IB' | 'IIA' | 'IIB' | 'IIIA' | 'IIIB' | 'IIIC' | 'IVA' | 'IVB';
+    grade?: 1 | 2 | 3;
+    tumorSize?: number;
+    lymphNodeInvolvement?: number;
+    metastaticSites?: string[];
+    ecogStatus: 0 | 1 | 2 | 3 | 4;
+    genomicAlterations: {
+        gene: string;
+        alteration: string;
+        type: 'mutation' | 'amplification' | 'deletion' | 'fusion';
+        vaf?: number;
+    }[];
+    pdl1Score?: number;
+    pdl1ScoreType?: 'TPS' | 'CPS' | 'IC';
+    msiStatus?: 'MSI-H' | 'MSI-L' | 'MSS';
+    tmbValue?: number;
+    tmbStatus?: 'high' | 'low';
+    hrdScore?: number;
+    hrdStatus?: 'positive' | 'negative';
+    brcaStatus?: 'BRCA1' | 'BRCA2' | 'wild-type';
+    ldh?: number;
+    albumin?: number;
+    hemoglobin?: number;
+    neutrophils?: number;
+    lymphocytes?: number;
+    platelets?: number;
+    creatinine?: number;
+    bilirubin?: number;
+    alkalinePhosphatase?: number;
+    priorLines?: number;
+    priorTherapies?: string[];
+    priorResponse?: 'CR' | 'PR' | 'SD' | 'PD';
+    treatmentFreeInterval?: number;
+    comorbidityIndex?: number;
+    organFunction?: {
+        cardiac?: 'normal' | 'impaired';
+        hepatic?: 'normal' | 'impaired';
+        renal?: 'normal' | 'impaired';
+        pulmonary?: 'normal' | 'impaired';
+    };
+}
+export interface TreatmentFeatures {
+    regimen: string;
+    drugs: string[];
+    treatmentType: 'chemotherapy' | 'immunotherapy' | 'targeted' | 'combination' | 'radiation' | 'surgery' | 'car-t';
+    setting: 'neoadjuvant' | 'adjuvant' | 'first-line' | 'second-line' | 'third-line-plus' | 'maintenance';
+    dosing?: 'standard' | 'reduced' | 'dose-dense';
+    schedule?: string;
+}
+export interface ResponsePrediction {
+    predictedResponse: 'CR' | 'PR' | 'SD' | 'PD';
+    probabilities: {
+        completeResponse: number;
+        partialResponse: number;
+        stableDisease: number;
+        progressiveDisease: number;
+    };
+    confidence: number;
+    objectiveResponseRate: number;
+    diseaseControlRate: number;
+    timeToResponse?: {
+        median: number;
+        range: [number, number];
+    };
+}
+export interface SurvivalPrediction {
+    pfs: {
+        median: number;
+        sixMonth: number;
+        twelveMonth: number;
+        twentyFourMonth: number;
+        confidence: number;
+        hazardRatio?: number;
+    };
+    os: {
+        median: number;
+        twelveMonth: number;
+        twentyFourMonth: number;
+        fiveYear: number;
+        confidence: number;
+        hazardRatio?: number;
+    };
+    riskGroup: 'low' | 'intermediate-low' | 'intermediate-high' | 'high';
+    riskScore: number;
+}
+export interface ToxicityPrediction {
+    overallRisk: 'low' | 'moderate' | 'high';
+    grade3PlusRisk: number;
+    specificRisks: {
+        toxicity: string;
+        grade: 1 | 2 | 3 | 4 | 5;
+        probability: number;
+        timeToOnset?: {
+            median: number;
+            unit: 'days' | 'weeks' | 'cycles';
+        };
+        reversible: boolean;
+        management?: string;
+    }[];
+    iraeRisk?: {
+        any: number;
+        grade3Plus: number;
+        specificOrgans: {
+            organ: string;
+            risk: number;
+        }[];
+    };
+    doseModification?: {
+        recommended: boolean;
+        reduction: number;
+        reason: string;
+    };
+}
+export interface ResistancePrediction {
+    intrinsicResistanceRisk: number;
+    acquiredResistanceRisk: number;
+    predictedMechanisms: {
+        mechanism: string;
+        probability: number;
+        monitoringBiomarker?: string;
+    }[];
+    timeToResistance?: {
+        median: number;
+        range: [number, number];
+    };
+    nextLineOptions: {
+        therapy: string;
+        rationale: string;
+        expectedBenefit: number;
+    }[];
+}
+export interface TherapyRanking {
+    therapies: {
+        regimen: string;
+        drugs: string[];
+        rank: number;
+        predictions: {
+            responseRate: number;
+            pfsSurvival: number;
+            osSurvival: number;
+            toxicityRisk: number;
+            qualityOfLifeScore: number;
+        };
+        overallScore: number;
+        confidence: number;
+        matchingBiomarkers: string[];
+        fdaApproved: boolean;
+        nccnRecommended: boolean;
+        considerations: string[];
+        contraindications?: string[];
+    }[];
+    bestChoice: {
+        regimen: string;
+        rationale: string[];
+    };
+}
+export interface MLModel {
+    id: string;
+    name: string;
+    version: string;
+    type: 'classification' | 'regression' | 'survival' | 'ranking';
+    target: 'response' | 'pfs' | 'os' | 'toxicity' | 'resistance';
+    cancerTypes: string[];
+    performance: {
+        auc?: number;
+        accuracy?: number;
+        sensitivity?: number;
+        specificity?: number;
+        cIndex?: number;
+        calibration?: number;
+        brier?: number;
+    };
+    validation: {
+        method: 'cross-validation' | 'temporal' | 'external' | 'prospective';
+        cohortSize: number;
+        testSetSize: number;
+        validationDate: Date;
+    };
+    features: string[];
+    importantFeatures: {
+        feature: string;
+        importance: number;
+    }[];
+    status: 'development' | 'validation' | 'clinical-use' | 'deprecated';
+    regulatoryStatus?: 'not-submitted' | 'pending' | 'cleared' | '510k' | 'de-novo';
+}
+export interface ModelRegistry {
+    models: MLModel[];
+    getModel(id: string): MLModel | undefined;
+    getBestModel(target: MLModel['target'], cancerType: string): MLModel | undefined;
+    registerModel(model: MLModel): void;
+}
+export declare class OutcomePredictorService extends EventEmitter {
+    private modelRegistry;
+    private featureEncoders;
+    private predictionCache;
+    private cacheDuration;
+    constructor();
+    /**
+     * Predict treatment response
+     */
+    predictResponse(patient: PatientFeatures, treatment: TreatmentFeatures): Promise<ResponsePrediction>;
+    /**
+     * Predict survival outcomes
+     */
+    predictSurvival(patient: PatientFeatures, treatment: TreatmentFeatures): Promise<SurvivalPrediction>;
+    /**
+     * Predict toxicity risk
+     */
+    predictToxicity(patient: PatientFeatures, treatment: TreatmentFeatures): Promise<ToxicityPrediction>;
+    /**
+     * Predict resistance development
+     */
+    predictResistance(patient: PatientFeatures, treatment: TreatmentFeatures): Promise<ResistancePrediction>;
+    /**
+     * Rank treatment options
+     */
+    rankTherapies(patient: PatientFeatures, treatmentOptions: TreatmentFeatures[], preferences?: {
+        prioritizeEfficacy?: boolean;
+        prioritizeToxicity?: boolean;
+        prioritizeQoL?: boolean;
+    }): Promise<TherapyRanking>;
+    /**
+     * Get comprehensive prediction report
+     */
+    getComprehensivePrediction(patient: PatientFeatures, treatment: TreatmentFeatures): Promise<{
+        response: ResponsePrediction;
+        survival: SurvivalPrediction;
+        toxicity: ToxicityPrediction;
+        resistance: ResistancePrediction;
+        overallAssessment: {
+            recommendation: 'strongly-recommended' | 'recommended' | 'consider' | 'caution' | 'not-recommended';
+            rationale: string[];
+            caveats: string[];
+            alternativeOptions: string[];
+        };
+    }>;
+    private computeResponsePrediction;
+    private computeSurvivalPrediction;
+    private computeToxicityPrediction;
+    private computeResistancePrediction;
+    private initializeDefaultModels;
+    private initializeFeatureEncoders;
+    private encodeFeatures;
+    private getBestModel;
+    private hasBiomarkerMatch;
+    private hasImmunotherapyDrug;
+    private getDrugToxicityProfiles;
+    private getResistanceMechanisms;
+    private getNextLineOptions;
+    private estimateQoLScore;
+    private getMatchingBiomarkers;
+    private isBiomarkerRelevant;
+    private checkFDAApproval;
+    private checkNCCNRecommendation;
+    private getConsiderations;
+    private generateOverallAssessment;
+    private getCacheKey;
+    private getFromCache;
+    private setCache;
+    /**
+     * Register a new model
+     */
+    registerModel(model: MLModel): void;
+    /**
+     * Get model performance metrics
+     */
+    getModelMetrics(modelId: string): MLModel['performance'] | undefined;
+    /**
+     * List all available models
+     */
+    listModels(): MLModel[];
+}
+export default OutcomePredictorService;
+//# sourceMappingURL=outcomePredictor.d.ts.map

package/dist/ml/outcomePredictor.d.ts.map

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